Andrew P. Hinck
Affiliations: | 1997-2015 | University of Texas Health Science Center in San Antonio | |
2015- | University of Pittsburgh, Pittsburgh, PA, United States |
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Parents
Sign in to add mentorJohn L. Markley | grad student | 1987-1993 | UW Madison |
Laura Lee Kiessling | post-doc | UW Madison | |
Dennis A. Torchia | research scientist | NIH (Physics Tree) |
Children
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Publications
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Wong SJ, Senkovich O, Artigas JA, et al. (2020) Structure and role of BCOR PUFD in non-canonical PRC1 assembly and disease. Biochemistry |
Kim SK, Henen MA, Hinck AP. (2019) Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Experimental Biology and Medicine (Maywood, N.J.). 1535370219881160 |
Kim SK, Whitley MJ, Krzysiak TC, et al. (2019) Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin. Structure (London, England : 1993) |
Goebel EJ, Corpina RA, Hinck CS, et al. (2019) Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proceedings of the National Academy of Sciences of the United States of America |
Henen MA, Mahlawat P, Zwieb C, et al. (2018) TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and Inhibin-α. The Journal of Biological Chemistry |
Hinck AP. (2018) Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism. Bioorganic & Medicinal Chemistry |
Ramachandran A, Vizan P, Das D, et al. (2018) TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition. Elife. 7 |
Johnston CJC, Smyth DJ, Kodali RB, et al. (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications. 8: 1741 |
Kim SK, Barron L, Hinck CS, et al. (2017) An Engineered TGF-β Monomer that Functions as a Dominant Negative to Block TGF-β Signaling. The Journal of Biological Chemistry |
Hinck A, Henen MA, Zwieb C, et al. (2017) Methyl-Labeling Assisted NMR Structure Determination of a 66 KDA Growth Factor-Receptor Complex Biophysical Journal. 112: 487a-488a |