David N. Frick, PH.D.

2000-2010 Biochemistry and Molecular Biology New York Medical College, New York, NY, United States 
 2010- Chemistry & BIOCHEMISTRY University of Wisconsin, Milwaukee 
Biochemistry, Molecular Biology, Virology Biology
"David Frick"
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Cross-listing: Cell Biology Tree


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Maurice J. Bessman grad student 1990-1996 (Physics Tree)
Charles C. Richardson post-doc


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Craig A. Belon grad student 2010 New York Medical College (Cell Biology Tree)
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Virdi RS, Bavisotto RV, Hopper NC, et al. (2020) Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. Slas Discovery : Advancing Life Sciences R & D. 2472555220960428
Frick DN, Virdi RS, Vuksanovic N, et al. (2020) Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3. Biochemistry
Kaushik-Basu N, Ratmanova NK, Manvar D, et al. (2016) Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents. European Journal of Medicinal Chemistry. 122: 319-325
Provazzi PJ, Mukherjee S, Hanson AM, et al. (2015) Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient. Plos One. 10: e0144638
Sweeney NL, Hanson AM, Mukherjee S, et al. (2015) Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. Acs Infectious Diseases. 1: 140-148
Ndjomou J, Corby MJ, Sweeney NL, et al. (2015) Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy. Acs Chemical Biology
Andreev IA, Manvar D, Barreca ML, et al. (2015) Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold. European Journal of Medicinal Chemistry. 96: 250-8
Mukherjee S, Weiner WS, Schroeder CE, et al. (2014) Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication. Acs Chemical Biology. 9: 2393-403
Aydin C, Mukherjee S, Hanson AM, et al. (2013) The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities. Protein Science : a Publication of the Protein Society. 22: 1786-98
Shadrick WR, Mukherjee S, Hanson AM, et al. (2013) Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP. Biochemistry. 52: 6151-9
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