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David K. Orren

Affiliations: 
Medicine University of Kentucky, Lexington, KY 
Area:
Toxicology, Biochemistry
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"David Orren"
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Enerlyn M. Lozada Santiago grad student 2011 University of Kentucky
Deanna N. Edwards grad student 2012 University of Kentucky

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Wang L, He D, Li Q, et al. (2024) PLK1 phosphorylates WRN at replication forks. The Journal of Pharmacology and Experimental Therapeutics. 392: 100051
Orren DK, Machwe A. (2024) Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein. International Journal of Molecular Sciences. 25
Orren DK, Machwe A. (2019) Lysine Acetylation of Proteins and Its Characterization in Human Systems. Methods in Molecular Biology (Clifton, N.J.). 1983: 107-130
Holcomb N, Goswami M, Han SG, et al. (2017) Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC. Dna Repair
Holcomb N, Goswami M, Han SG, et al. (2016) Exposure of Human Lung Cells to Tobacco Smoke Condensate Inhibits the Nucleotide Excision Repair Pathway. Plos One. 11: e0158858
Orren DK. (2016) The Nobel Prize in Chemistry 2015: Exciting discoveries in DNA repair by Aziz Sancar. Science China. Life Sciences. 59: 97-102
Edwards DN, Machwe A, Chen L, et al. (2015) The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events. Nature Communications. 6: 8331
Lozada E, Yi J, Luo J, et al. (2014) Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities. Biogerontology. 15: 347-66
Edwards DN, Orren DK, Machwe A. (2014) Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2. Nucleic Acids Research. 42: 7748-61
Edwards DN, Machwe A, Wang Z, et al. (2014) Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change. Plos One. 9: e80664
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