| Year |
Citation |
Score |
| 2019 |
Orren DK, Machwe A. Lysine Acetylation of Proteins and Its Characterization in Human Systems. Methods in Molecular Biology (Clifton, N.J.). 1983: 107-130. PMID 31087295 DOI: 10.1007/978-1-4939-9434-2_7 |
0.329 |
|
| 2017 |
Holcomb N, Goswami M, Han SG, Scott T, D'Orazio J, Orren DK, Gairola CG, Mellon I. Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC. Dna Repair. PMID 28237621 DOI: 10.1016/J.Dnarep.2017.02.009 |
0.372 |
|
| 2016 |
Holcomb N, Goswami M, Han SG, Clark S, Orren DK, Gairola CG, Mellon I. Exposure of Human Lung Cells to Tobacco Smoke Condensate Inhibits the Nucleotide Excision Repair Pathway. Plos One. 11: e0158858. PMID 27391141 DOI: 10.1371/Journal.Pone.0158858 |
0.389 |
|
| 2016 |
Orren DK. The Nobel Prize in Chemistry 2015: Exciting discoveries in DNA repair by Aziz Sancar. Science China. Life Sciences. 59: 97-102. PMID 26712032 DOI: 10.1007/S11427-015-4994-1 |
0.504 |
|
| 2015 |
Edwards DN, Machwe A, Chen L, Bohr VA, Orren DK. The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events. Nature Communications. 6: 8331. PMID 26420422 DOI: 10.1038/Ncomms9331 |
0.675 |
|
| 2014 |
Lozada E, Yi J, Luo J, Orren DK. Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities. Biogerontology. 15: 347-66. PMID 24965941 DOI: 10.1007/S10522-014-9506-3 |
0.611 |
|
| 2014 |
Edwards DN, Orren DK, Machwe A. Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2. Nucleic Acids Research. 42: 7748-61. PMID 24880691 DOI: 10.1093/Nar/Gku454 |
0.71 |
|
| 2014 |
Edwards DN, Machwe A, Wang Z, Orren DK. Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change. Plos One. 9: e80664. PMID 24454683 DOI: 10.1371/Journal.Pone.0080664 |
0.673 |
|
| 2012 |
Chan NL, Hou C, Zhang T, Yuan F, Machwe A, Huang J, Orren DK, Gu L, Li GM. The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins. The Journal of Biological Chemistry. 287: 30151-6. PMID 22787159 DOI: 10.1074/Jbc.M112.389791 |
0.482 |
|
| 2011 |
Machwe A, Karale R, Xu X, Liu Y, Orren DK. The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks. Biochemistry. 50: 6774-88. PMID 21736299 DOI: 10.1021/Bi2001054 |
0.564 |
|
| 2011 |
Machwe A, Lozada E, Wold MS, Li GM, Orren DK. Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. The Journal of Biological Chemistry. 286: 3497-508. PMID 21107010 DOI: 10.1074/Jbc.M110.105411 |
0.6 |
|
| 2010 |
Li K, Wang R, Lozada E, Fan W, Orren DK, Luo J. Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. Plos One. 5: e10341. PMID 20428248 DOI: 10.1371/Journal.Pone.0010341 |
0.552 |
|
| 2009 |
Spencer WA, Singh J, Orren DK. Formation and differential repair of covalent DNA adducts generated by treatment of human cells with (+/-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxide. Chemical Research in Toxicology. 22: 81-9. PMID 19053321 DOI: 10.1021/Tx8001675 |
0.499 |
|
| 2008 |
Li K, Casta A, Wang R, Lozada E, Fan W, Kane S, Ge Q, Gu W, Orren D, Luo J. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. The Journal of Biological Chemistry. 283: 7590-8. PMID 18203716 DOI: 10.1074/Jbc.M709707200 |
0.554 |
|
| 2007 |
Machwe A, Xiao L, Lloyd RG, Bolt E, Orren DK. Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. Nucleic Acids Research. 35: 5729-47. PMID 17717003 DOI: 10.1093/Nar/Gkm561 |
0.548 |
|
| 2006 |
Machwe A, Xiao L, Groden J, Orren DK. The Werner and Bloom syndrome proteins catalyze regression of a model replication fork. Biochemistry. 45: 13939-46. PMID 17115688 DOI: 10.1021/Bi0615487 |
0.571 |
|
| 2006 |
Orren DK. Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging. Frontiers in Bioscience : a Journal and Virtual Library. 11: 2657-71. PMID 16720342 DOI: 10.2741/1999 |
0.59 |
|
| 2006 |
Machwe A, Xiao L, Orren DK. Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains. Bmc Molecular Biology. 7: 6. PMID 16503984 DOI: 10.1186/1471-2199-7-6 |
0.577 |
|
| 2006 |
Machwe A, Lozada EM, Xiao L, Orren DK. Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins. Bmc Molecular Biology. 7: 1. PMID 16412221 DOI: 10.1186/1471-2199-7-1 |
0.589 |
|
| 2005 |
Orren DK. The irresistible resistance of nonsense: Evolutionary adaptation of termination codons to minimize the effects of common DNA damage. Dna Repair. 4: 1208-12. PMID 16095980 DOI: 10.1016/J.Dnarep.2005.06.012 |
0.468 |
|
| 2005 |
Machwe A, Xiao L, Groden J, Matson SW, Orren DK. RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange. The Journal of Biological Chemistry. 280: 23397-407. PMID 15845538 DOI: 10.1074/Jbc.M414130200 |
0.589 |
|
| 2004 |
Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J. Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Human Molecular Genetics. 13: 1919-32. PMID 15229185 DOI: 10.1093/Hmg/Ddh193 |
0.545 |
|
| 2004 |
Machwe A, Xiao L, Orren DK. TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA. Oncogene. 23: 149-56. PMID 14712220 DOI: 10.1038/Sj.Onc.1206906 |
0.592 |
|
| 2002 |
Orren DK, Theodore S, Machwe A. The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro. Biochemistry. 41: 13483-8. PMID 12427008 DOI: 10.1021/Bi0266986 |
0.555 |
|
| 2002 |
Machwe A, Xiao L, Theodore S, Orren DK. DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA. The Journal of Biological Chemistry. 277: 4492-504. PMID 11717307 DOI: 10.1074/Jbc.M108880200 |
0.555 |
|
| 2001 |
Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA. A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA Nucleic Acids Research. 29: 1926-1934. PMID 11328876 DOI: 10.1093/Nar/29.9.1926 |
0.608 |
|
| 2001 |
Bohr VA, Cooper M, Orren D, Machwe A, Piotrowski J, Sommers J, Karmakar P, Brosh R. Werner syndrome protein: biochemical properties and functional interactions. Experimental Gerontology. 35: 695-702. PMID 11053659 DOI: 10.1016/S0531-5565(00)00145-5 |
0.565 |
|
| 2000 |
Machwe A, Orren DK, Bohr VA. Accelerated methylation ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts Faseb Journal. 14: 1715-1724. PMID 10973920 DOI: 10.1096/Fj.99-0926Com |
0.365 |
|
| 2000 |
Machwe A, Ganunis R, Bohr VA, Orren DK. Selective blockage of the 3'→5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA Nucleic Acids Research. 28: 2762-2770. PMID 10908333 DOI: 10.1093/Nar/28.14.2762 |
0.608 |
|
| 2000 |
Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA. Ku complex interacts with and stimulates the Werner protein Genes and Development. 14: 907-912. PMID 10783163 DOI: 10.1101/Gad.14.8.907 |
0.495 |
|
| 1999 |
Orren DK, Brosh RM, Nehlin JO, Machwe A, Gray MD, Bohr VA. Enzymatic and DNA binding properties of purified WRN protein: High affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO Nucleic Acids Research. 27: 3557-3566. PMID 10446247 DOI: 10.1093/Nar/27.17.3557 |
0.613 |
|
| 1999 |
Balajee AS, Machwe A, May A, Gray MD, Oshima J, Martin GM, Nehlin JO, Brosh R, Orren DK, Bohr VA. The Werner syndrome protein is involved in RNA polymerase II transcription Molecular Biology of the Cell. 10: 2655-2668. PMID 10436020 DOI: 10.1091/Mbc.10.8.2655 |
0.405 |
|
| 1999 |
Brosh RM, Orren DK, Nehlin JO, Ravn PH, Kenny MK, Machwe A, Bohr VA. Functional and physical interaction between WRN helicase and human replication protein A Journal of Biological Chemistry. 274: 18341-18350. PMID 10373438 DOI: 10.1074/Jbc.274.26.18341 |
0.582 |
|
| 1998 |
Bohr VA, Dianov G, Balajee A, May A, Orren DK. DNA repair and transcription in human premature aging disorders Journal of Investigative Dermatology Symposium Proceedings. 3: 11-13. PMID 9732050 DOI: 10.1038/Jidsymp.1998.4 |
0.597 |
|
| 1997 |
Orren DK, Petersen LN, Bohr VA. Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis Molecular Biology of the Cell. 8: 1129-1142. PMID 9201721 DOI: 10.1091/Mbc.8.6.1129 |
0.528 |
|
| 1997 |
Kruk PA, Orren DK, Bohr VA. Telomerase activity is elevated in early S phase in hamster cells Biochemical and Biophysical Research Communications. 233: 717-722. PMID 9168921 DOI: 10.1006/Bbrc.1997.6549 |
0.332 |
|
| 1997 |
Bohr VA, Balajce A, Dianov G, Machwe A, May A, Nehlin J, Orren D. O VI.3 Regulation of gene repair and transcription in normal human cells, and in premature aging syndromes Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S41. DOI: 10.1016/S0027-5107(97)82735-2 |
0.34 |
|
| 1996 |
Orren DK, Dianov GL, Bohr VA. The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61 Nucleic Acids Research. 24: 3317-3322. PMID 8811084 DOI: 10.1093/Nar/24.17.3317 |
0.51 |
|
| 1996 |
Link CJ, Orren D, Muldoon R, Cook JA, Bohr VA. Pentoxifylline inhibits gene-specific repair of UV-induced DNA damage in hamster cells Radiation Oncology Investigations. 4: 115-121. DOI: 10.1002/(Sici)1520-6823(1996)4:3<115::Aid-Roi3>3.0.Co;2-0 |
0.473 |
|
| 1995 |
Petersen LN, Orren DK, Bohr VA. Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle Molecular and Cellular Biology. 15: 3731-3737. PMID 7791780 DOI: 10.1128/Mcb.15.7.3731 |
0.443 |
|
| 1995 |
Orren DK, Petersen LN, Bohr VA. A UV-responsive G2 checkpoint in rodent cells Molecular and Cellular Biology. 15: 3722-3730. PMID 7791779 DOI: 10.1128/Mcb.15.7.3722 |
0.332 |
|
| 1992 |
Orren DK, Selby CP, Hearst JE, Sancar A. Post-incision steps of nucleotide excision repair in Escherichia coli. Disassembly of the UvrBC-DNA complex by helicase II and DNA polymerase I. The Journal of Biological Chemistry. 267: 780-8. PMID 1530937 |
0.506 |
|
| 1990 |
Orren DK, Sancar A. Formation and enzymatic properties of the UvrB·DNA complex Journal of Biological Chemistry. 265: 15796-15803. PMID 2168423 |
0.428 |
|
| 1989 |
Orren DK, Sancar A. The (A)BC excinuclease of Escherichia coli has only the UvrB and UvrC subunits in the incision complex Proceedings of the National Academy of Sciences of the United States of America. 86: 5237-5241. PMID 2546148 DOI: 10.1073/Pnas.86.14.5237 |
0.545 |
|
| 1987 |
Orren DK, Sancar A. New discoveries in the enzymology of DNA repair Cancer Reviews. 7: 5-27. |
0.435 |
|
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