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Sean C. Gay, PhD

Affiliations: 
2003-2008 Chemistry University of California, Davis, Davis, CA 
 2008-2011 Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, La Jolla, CA 
 2012-2013 Integrative Structural and Computational Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Structural biology
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Parents

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Andrew J. Fisher grad student 2003-2008 UC Davis
James R. Halpert post-doc 2008-2011 UCSD
Vadim Cherezov post-doc 2012-2013 Scripps Institute

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Publications

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Zhang H, Gay SC, Shah M, et al. (2013) Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis Biochemistry. 52: 355-364
Wilderman PR, Gay SC, Jang HH, et al. (2012) Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. The Febs Journal. 279: 1607-20
Gay SC, Zhang H, Wilderman PR, et al. (2011) Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 50: 4903-11
Gay SC, Roberts AG, Halpert JR. (2010) Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. Future Medicinal Chemistry. 2: 1451-68
Gay SC, Roberts AG, Maekawa K, et al. (2010) Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 49: 8709-20
Gay SC, Shah MB, Talakad JC, et al. (2010) Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Molecular Pharmacology. 77: 529-38
Gay SC, Segel IH, Fisher AJ. (2009) Structure of the two-domain hexameric APS kinase from Thiobacillus denitrificans: structural basis for the absence of ATP sulfurylase activity. Acta Crystallographica. Section D, Biological Crystallography. 65: 1021-31
Gay SC, Fribourgh JL, Donohoue PD, et al. (2009) Kinetic properties of ATP sulfurylase and APS kinase from Thiobacillus denitrificans. Archives of Biochemistry and Biophysics. 489: 110-7
Gay SC, Sun L, Maekawa K, et al. (2009) Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. Biochemistry. 48: 4762-71
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