Aaron Ciechanover
Affiliations: | Technion - Israel Institute of Technology, Haifa, Haifa District, Israel |
Area:
BiochemistryWebsite:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2004/ciechanover.htmlGoogle:
"Aaron Ciechanover"Bio:
http://www.nasonline.org/member-directory/members/20015154.html
The Nobel Prize in Chemistry 2004 was awarded jointly to Aaron Ciechanover, Avram Hershko and Irwin Rose "for the discovery of ubiquitin-mediated protein degradation".
Mean distance: 9.05
Parents
Sign in to add mentor| Avram Hershko | grad student | 1976-1981 | Technion |
| Irwin A. Rose | grad student | 1978-1981 | Fox Chase Cancer Center |
| Harvey F. Lodish | post-doc | MIT |
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Publications
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| Gottfried Y, Lulu-Shimron C, Goldhirsh G, et al. (2024) Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC1. Biochemical and Biophysical Research Communications. 745: 151231 |
| Livneh I, Cohen-Kaplan V, Fabre B, et al. (2023) Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress. Molecular Cell. 83: 3333-3346.e5 |
| Drula R, Iluta S, Gulei D, et al. (2022) Exploiting the ubiquitin system in myeloid malignancies. From basic research to drug discovery in MDS and AML. Blood Reviews. 100971 |
| Fu A, Cohen-Kaplan V, Avni N, et al. (2021) p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Udasin RG, Gottfried Y, Fabre B, et al. (2020) The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation. Biochemical and Biophysical Research Communications |
| Ziv NE, Ciechanover A. (2020) A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin's aggregation. Cell Death and Differentiation |
| Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, et al. (2020) Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proceedings of the National Academy of Sciences of the United States of America |
| Wang X, Bustos MA, Zhang X, et al. (2020) Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors. Cancers. 12 |
| Ji CH, Kim HY, Heo AJ, et al. (2019) The N-Degron Pathway Mediates ER-phagy. Molecular Cell |
| Fabre B, Livneh I, Ziv T, et al. (2019) Identification of proteins regulated by the proteasome following induction of endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. 517: 188-192 |