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Aaron Ciechanover

Technion - Israel Institute of Technology, Haifa, Haifa District, Israel 
"Aaron Ciechanover"
The Nobel Prize in Chemistry 2004 was awarded jointly to Aaron Ciechanover, Avram Hershko and Irwin Rose "for the discovery of ubiquitin-mediated protein degradation".

Mean distance: 9.05


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Avram Hershko grad student 1976-1981 Technion
Irwin A. Rose grad student 1978-1981 Fox Chase Cancer Center
Harvey F. Lodish post-doc MIT


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Nitzan Shabek grad student
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Livneh I, Cohen-Kaplan V, Fabre B, et al. (2023) Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress. Molecular Cell. 83: 3333-3346.e5
Drula R, Iluta S, Gulei D, et al. (2022) Exploiting the ubiquitin system in myeloid malignancies. From basic research to drug discovery in MDS and AML. Blood Reviews. 100971
Fu A, Cohen-Kaplan V, Avni N, et al. (2021) p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin-proteasome system. Proceedings of the National Academy of Sciences of the United States of America. 118
Udasin RG, Gottfried Y, Fabre B, et al. (2020) The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation. Biochemical and Biophysical Research Communications
Ziv NE, Ciechanover A. (2020) A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin's aggregation. Cell Death and Differentiation
Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, et al. (2020) Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proceedings of the National Academy of Sciences of the United States of America
Wang X, Bustos MA, Zhang X, et al. (2020) Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors. Cancers. 12
Ji CH, Kim HY, Heo AJ, et al. (2019) The N-Degron Pathway Mediates ER-phagy. Molecular Cell
Fabre B, Livneh I, Ziv T, et al. (2019) Identification of proteins regulated by the proteasome following induction of endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. 517: 188-192
Nawatha M, Rogers JM, Bonn SM, et al. (2019) De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nature Chemistry
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