Mark S. Cushman

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
Pharmaceutical Chemistry
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Parents

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Neal Castagnoli grad student 1969-1973 UCSF
George H. Büchi post-doc 1973-1975 MIT

Children

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Mark L. Micklatcher grad student 2000 Purdue
Jinhua Chen grad student 2004 Purdue
Allison B. Edsall grad student 2004 Purdue
Alexandra S. Ioanoviciu grad student 2005 Purdue
Martin Conda-Sheridan grad student 2007-2012 Purdue
Asit Kumar Chakraborti post-doc 1987-1989 Purdue
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Publications

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Fan BZ, Hiasa H, Lv W, et al. (2020) Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. European Journal of Medicinal Chemistry. 193: 112222
Wang KB, Elsayed MSA, Wu G, et al. (2019) Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC. Journal of the American Chemical Society
Li XM, Lv W, Guo SY, et al. (2019) Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. European Journal of Medicinal Chemistry. 171: 235-254
Ma CX, Lv W, Li YX, et al. (2019) Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. European Journal of Medicinal Chemistry. 169: 1-20
Pommier Y, Cushman M, Doroshow JH. (2018) Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins. Oncotarget. 9: 37286-37288
Elsayed MSA, Nielsen JJ, Park S, et al. (2018) Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series. Journal of Medicinal Chemistry
Lee HM, Clark EP, Kuijer MB, et al. (2018) Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant gene associated with Angelman syndrome. Molecular Autism. 9: 45
Marzi L, Agama K, Murai J, et al. (2018) Novel fluoroindenoisoquinoline non-camptothecin topoisomerase I inhibitors. Molecular Cancer Therapeutics
Pommier Y, Marzi L, Ohler ZW, et al. (2018) Abstract 4855: Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high SLFN11 expression Cancer Research. 78: 4855-4855
Wang K, Elsayed MSA, Wu G, et al. (2018) Abstract 2662: Indenoisoquinoline topoisomerase I inhibitors target the DNA G-quadruplex formed in the c-Myc promoter and cause MYC downregulation Cancer Research. 78: 2662-2662
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