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Mark S. Cushman

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
Pharmaceutical Chemistry
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Parents

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Neal Castagnoli grad student 1969-1973 UCSF
George H. Büchi post-doc 1973-1975 MIT

Children

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Prem Mohan grad student 1984 Purdue
Mark L. Micklatcher grad student 2000 Purdue
Jinhua Chen grad student 2004 Purdue
Allison B. Edsall grad student 2004 Purdue
Alexandra S. Ioanoviciu grad student 2005 Purdue
Maris A. Cinelli grad student 2011 Purdue
Martin Conda-Sheridan grad student 2007-2012 Purdue
Asit Kumar Chakraborti post-doc 1987-1989 Purdue

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Publications

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Fan BZ, Hiasa H, Lv W, et al. (2020) Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. European Journal of Medicinal Chemistry. 193: 112222
Reguera RM, Álvarez-Velilla R, Domínguez-Asenjo B, et al. (2019) Antiparasitic effect of synthetic aromathecins on Leishmania infantum. Bmc Veterinary Research. 15: 405
Gutiérrez-Corbo C, Álvarez-Velilla R, Reguera RM, et al. (2019) Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 11: 39-48
Wang KB, Elsayed MSA, Wu G, et al. (2019) Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC. Journal of the American Chemical Society
Li XM, Lv W, Guo SY, et al. (2019) Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. European Journal of Medicinal Chemistry. 171: 235-254
Ma CX, Lv W, Li YX, et al. (2019) Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. European Journal of Medicinal Chemistry. 169: 1-20
Pommier Y, Cushman M, Doroshow JH. (2018) Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins. Oncotarget. 9: 37286-37288
Elsayed MSA, Nielsen JJ, Park S, et al. (2018) Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series. Journal of Medicinal Chemistry
Lee HM, Clark EP, Kuijer MB, et al. (2018) Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant gene associated with Angelman syndrome. Molecular Autism. 9: 45
Nenortas NP, Cinelli MA, Morrell AE, et al. (2018) Activity of aromathecins against African trypanosomes. Antimicrobial Agents and Chemotherapy
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