Douglas M. Freymann
Affiliations: | Molecular Pharmacology and Biological Chemistry | Northwestern University, Evanston, IL |
Area:
structural basis for interactions between proteins, and between proteins and small moleculesWebsite:
https://fsmweb.northwestern.edu/faculty/FacultyProfile.cfm?xid=10268Google:
"Douglas Freymann"Mean distance: 8.1 | S | N | B | C | P |
Parents
Sign in to add mentor| Don C. Wiley | grad student | 1989 | Harvard | |
| (The partial crystal structure of VSG from Trypanosoma brucei) | ||||
| Peter Walter | post-doc | 1993 | UCSF | |
| Robert M. Stroud | post-doc | 1989-1997 | UCSF | |
Children
Sign in to add trainee| Ursula D. Ramirez | grad student | 2006 | Northwestern |
| John A. Cieslak | grad student | 2010 | Northwestern |
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Publications
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| Smith KP, Focia PJ, Chakravarthy S, et al. (2020) Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase. Journal of Structural Biology. 212: 107656 |
| Yeung PS, Yamashita M, Ing CE, et al. (2018) Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating. Proceedings of the National Academy of Sciences of the United States of America |
| Smith KP, Focia PJ, Zhang Y, et al. (2017) The Two GTPase Domains of the Outer Mitochondrial Membrane Protein Miro have Novel Active Site Conformations and Distinct Biochemical Properties Biophysical Journal. 112: 177a-178a |
| Klosowiak JL, Park S, Smith KP, et al. (2016) Structural insights into Parkin substrate lysine targeting from minimal Miro substrates. Scientific Reports. 6: 33019 |
| Klosowiak J, Focia P, Chakravarthy S, et al. (2015) Structures of Human Miro1 Reveal Conformational Changes Biophysical Journal. 108: 155a |
| Klosowiak JL, Focia PJ, Chakravarthy S, et al. (2013) Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. Embo Reports. 14: 968-74 |
| Klosowiak JL, Focia PJ, Gonzalez MC, et al. (2013) Miro: A Driver of the Kinesin Motor Biophysical Journal. 104: 40a |
| Freymann DM, Nakamura Y, Focia PJ, et al. (2012) Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge). Acta Crystallographica. Section D, Biological Crystallography. 68: 1163-74 |
| Ramirez UD, Focia PJ, Freymann DM. (2008) Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh. Acta Crystallographica. Section D, Biological Crystallography. 64: 1043-53 |
| Gawronski-Salerno J, Coon JS, Focia PJ, et al. (2007) X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases. Proteins. 66: 984-95 |