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Douglas M. Freymann

Affiliations: 
Molecular Pharmacology and Biological Chemistry Northwestern University, Evanston, IL 
Area:
structural basis for interactions between proteins, and between proteins and small molecules
Website:
https://fsmweb.northwestern.edu/faculty/FacultyProfile.cfm?xid=10268
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"Douglas Freymann"
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SNBCP

Parents

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Don C. Wiley grad student 1989 Harvard
 (The partial crystal structure of VSG from Trypanosoma brucei)
Peter Walter post-doc 1993 UCSF
Robert M. Stroud post-doc 1989-1997 UCSF
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Publications

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Smith KP, Focia PJ, Chakravarthy S, et al. (2020) Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase. Journal of Structural Biology. 212: 107656
Klosowiak JL, Park S, Smith KP, et al. (2016) Structural insights into Parkin substrate lysine targeting from minimal Miro substrates. Scientific Reports. 6: 33019
Klosowiak JL, Focia PJ, Chakravarthy S, et al. (2013) Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. Embo Reports. 14: 968-74
Freymann DM, Nakamura Y, Focia PJ, et al. (2012) Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge). Acta Crystallographica. Section D, Biological Crystallography. 68: 1163-74
Ramirez UD, Focia PJ, Freymann DM. (2008) Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh. Acta Crystallographica. Section D, Biological Crystallography. 64: 1043-53
Gawronski-Salerno J, Coon JS, Focia PJ, et al. (2007) X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases. Proteins. 66: 984-95
Gawronski-Salerno J, Freymann DM. (2007) Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY. Journal of Structural Biology. 158: 122-8
Ramirez UD, Freymann DM. (2006) Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh. Acta Crystallographica. Section D, Biological Crystallography. 62: 1520-34
Focia PJ, Gawronski-Salerno J, Coon JS, et al. (2006) Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site. Journal of Molecular Biology. 360: 631-43
Bibak N, Paul RM, Freymann DM, et al. (2004) Purification of RanGDP, RanGTP, and RanGMPPNP by ion exchange chromatography. Analytical Biochemistry. 333: 57-64
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