Gavin Williams
Affiliations: | 2009- | Chemistry | North Carolina State University, Raleigh, NC |
Area:
Natural products, drug discovery, chemical biologyWebsite:
https://williamslab.wordpress.ncsu.edu/?page_id=13Google:
"Gavin Williams"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Alan Berry | grad student | 2002 | University of Leeds | |
| (Engineering the mechanisms of C-C bond forming enzymes.) | ||||
| Jon S. Thorson | post-doc | 2005-2009 | NCSU | |
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Publications
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| Paulsel TQ, Williams GJ. (2024) Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units. Chembiochem : a European Journal of Chemical Biology. e202400532 |
| Welch SD, Cossin J, Paulsel TQ, et al. (2024) Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides. Chem Catalysis. 2: 2440-2443 |
| Paulsel TQ, Williams GJ. (2023) Current State-of-the-Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products. Chembiochem : a European Journal of Chemical Biology. e202300386 |
| Calzini MA, Malico AA, Mitchler MM, et al. (2021) Protein engineering for natural product biosynthesis and synthetic biology applications. Protein Engineering, Design & Selection : Peds. 34 |
| Kalkreuter E, Bingham KS, Keeler AM, et al. (2021) Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase. Nature Communications. 12: 2193 |
| Mitchler MM, Garcia JM, Montero NE, et al. (2021) Transcription factor-based biosensors: a molecular-guided approach for natural product engineering. Current Opinion in Biotechnology. 69: 172-181 |
| Malico AA, Calzini MA, Gayen AK, et al. (2020) Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids. Journal of Industrial Microbiology & Biotechnology |
| Malico AA, Nichols L, Williams GJ. (2020) Synthetic biology enabling access to designer polyketides. Current Opinion in Chemical Biology. 58: 45-53 |
| Zin PPK, Williams G, Fourches D. (2020) SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides Journal of Cheminformatics. 12 |
| Kalkreuter E, Keeler AM, Malico AA, et al. (2019) Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli. Acs Synthetic Biology |