Joshua S. Chappie, PhD

2013- Cornell University, Ithaca, NY, United States 
X-ray crystallography, cryo-EM, GTPases, ATPases, nucleases, anti-phage defense systems, host-pathogen interactions, plant viruses
"Joshua Chappie"
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Christopher Miller research assistant 2001-2003 Brandeis
 (Undergraduate research)
Ronald Milligan grad student 2003-2009 The Scripps Research Institute, La Jolla, CA
Sandra Schmid grad student 2003-2009 The Scripps Research Institute, La Jolla, CA (Cell Biology Tree)
Frederick Dyda post-doc 2009-2013 National Institute of Diabetes and Digestive and Kidney Diseases (Microtree)


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Anthony Bui grad student 2018- Cornell
Christopher Hosford grad student 2013-2019 Cornell
Carl Schiltz grad student 2014-2019 Cornell
Myfanwy Adams grad student 2017-2023 Cornell


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Donald L. Court collaborator 2015- National Cancer Institute - Frederick
 (Structural, functional, and genetic characterization of the lambda RexA and RexB)
Lynn C Thomason collaborator 2015- (Microtree)
 (Structural, functional, and genetic characterization of the lambda RexA and RexB)
Craig Altier collaborator 2017- Cornell
 (Characterization and modulation of AraC-type activators involved in Salmonella pathogenesis)
Michelle L. Heck collaborator 2017- USDA - ARS
 (Molecular mechanisms and inhibition of aphid-transmissible plant viruses)
Thomas (Tom) Walz collaborator 2018- Rockefeller
 (Structural characterization of McrBC restriction complexes)
Marijn Ford collaborator 2016-2022 University of Pittsburgh
BETA: Related publications


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Dot EW, Thomason LC, Chappie JS. (2023) Everything OLD is new again: How structural, functional, and bioinformatic advances have redefined a neglected nuclease family. Molecular Microbiology
Schiltz CJ, Wilson JR, Hosford CJ, et al. (2022) Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids. Nature Communications. 13: 6368
Adams MC, Schiltz CJ, Heck ML, et al. (2021) Crystal structure of the potato leafroll virus coat protein and implications for viral assembly. Journal of Structural Biology. 214: 107811
Chowdhury R, Pavinski Bitar PD, Adams MC, et al. (2021) AraC-type regulators HilC and RtsA are directly controlled by an intestinal fatty acid to regulate Salmonella invasion Molecular Microbiology
Thomason LC, Schiltz CJ, Court C, et al. (2021) Bacteriophage λ RexA and RexB Functions Assist the Transition from Lysogeny to Lytic Growth. Molecular Microbiology
Niu Y, Suzuki H, Hosford CJ, et al. (2020) Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes. Nature Communications. 11: 5907
Bosire EM, Eade CR, Schiltz CJ, et al. (2020) Diffusible signal factors act through AraC-type transcriptional regulators as chemical cues to repress virulence of enteric pathogens Infection and Immunity
Hosford CJ, Adams MC, Niu Y, et al. (2020) The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins Journal of Structural Biology
Gray S, Santiago ER, Chappie JS, et al. (2020) Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation With Cell-Cycle Progression in a Cyclin-Independent Manner Cell Reports. 32: 107858
Jaimes JA, André NM, Chappie JS, et al. (2020) Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop. Journal of Molecular Biology
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