Paul L. Modrich
Affiliations: | Biochemistry | Duke University School of Medicine, Durham, NC, United States |
Area:
DNA Mismatch RepairWebsite:
http://www.biochem.duke.edu/modules/biochem_modrich_lab/index.php?id=1Google:
"Paul L. Modrich"Bio:
http://www.nasonline.org/member-directory/members/64183.html
http://www.hhmi.org/scientists/paul-l-modrich
http://searchworks.stanford.edu/view/5604960
http://www.jbc.org/content/282/3/e2.full.pdf
The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar "for mechanistic studies of DNA repair".
Mean distance: 9.19 | S | N | B | C | P |
Parents
Sign in to add mentor| Ethan Royal Signer | research assistant | 1965-1968 | MIT | |
| I. Robert Lehman | grad student | 1973 | Stanford Medical School | |
| (Structure, mechanism, and biological role of E. coli DNA ligase) | ||||
| Charles C. Richardson | post-doc | 1975-1978 | Harvard Medical School | |
Children
Sign in to add trainee| David J. Wright | grad student | 1983-1990 | Duke Medical School |
| Wendy Bedale | post-doc | ||
| Ravi R. Iyer | post-doc | 2001-2013 | Duke University / HHMI |
BETA: Related publications
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Publications
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| Kadyrova LY, Gujar V, Burdett V, et al. (2020) Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. Proceedings of the National Academy of Sciences of the United States of America |
| Sherrer SM, Penland E, Modrich P. (2018) The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease. Proceedings of the National Academy of Sciences of the United States of America |
| Genschel J, Kadyrova LY, Iyer RR, et al. (2017) Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America |
| Modrich P. (2016) Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). Angewandte Chemie (International Ed. in English). 55: 8490-501 |
| Lindahl T, Modrich P, Sancar A. (2016) The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage. Journal of the Association of Genetic Technologists. 42: 37-41 |
| Chen YS, Wu J, Modrich P, et al. (2016) Carboxyl-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCT Domain-containing Protein Mus101 and Fidelity of DNA Segregation. The Journal of Biological Chemistry |
| Qiu R, Sakato M, Sacho EJ, et al. (2015) MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences of the United States of America. 112: 10914-9 |
| Shao H, Baitinger C, Soderblom EJ, et al. (2014) Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Research. 42: 7104-12 |
| Lindsey-Boltz LA, Kemp MG, Reardon JT, et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. The Journal of Biological Chemistry. 289: 5074-82 |
| Pluciennik A, Burdett V, Baitinger C, et al. (2013) Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12277-82 |