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Paul L. Modrich

Biochemistry Duke University School of Medicine, Durham, NC, United States 
DNA Mismatch Repair
"Paul L. Modrich"
The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar "for mechanistic studies of DNA repair".

Mean distance: 9.19


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I. Robert Lehman grad student 1973 Stanford Medical School
 (Structure, mechanism, and biological role of E. coli DNA ligase)
Charles C. Richardson post-doc 1975-1978 Harvard Medical School
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Qiu R, Sakato M, Sacho EJ, et al. (2015) MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences of the United States of America. 112: 10914-9
Shao H, Baitinger C, Soderblom EJ, et al. (2014) Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Research. 42: 7104-12
Lindsey-Boltz LA, Kemp MG, Reardon JT, et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. The Journal of Biological Chemistry. 289: 5074-82
Pluciennik A, Burdett V, Baitinger C, et al. (2013) Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12277-82
Dowhan W, Nikaido H, Stubbe J, et al. (2013) Christian Raetz: scientist and friend extraordinaire. Annual Review of Biochemistry. 82: 1-24
Liu Y, Kadyrov FA, Modrich P. (2011) PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro Dna Repair. 10: 1145-1153
Tseng Q, Orans J, Hast MA, et al. (2011) Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 947-52
Orans J, McSweeney EA, Iyer RR, et al. (2011) Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 145: 212-23
Nimonkar AV, Genschel J, Kinoshita E, et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair Genes and Development. 25: 350-362
Pluciennik A, Dzantiev L, Iyer RR, et al. (2010) PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 107: 16066-71
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