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Paul L. Modrich

Affiliations: 
Biochemistry Duke University School of Medicine, Durham, NC, United States 
Area:
DNA Mismatch Repair
Website:
http://www.biochem.duke.edu/modules/biochem_modrich_lab/index.php?id=1
Google:
"Paul L. Modrich"
Bio:

http://www.nasonline.org/member-directory/members/64183.html
http://www.hhmi.org/scientists/paul-l-modrich
http://searchworks.stanford.edu/view/5604960
http://www.jbc.org/content/282/3/e2.full.pdf
The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar "for mechanistic studies of DNA repair".

Mean distance: 9.19
 
SNBCP

Parents

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I. Robert Lehman grad student 1973 Stanford Medical School
 (Structure, mechanism, and biological role of E. coli DNA ligase)
Charles C. Richardson post-doc 1975-1978 Harvard Medical School
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Publications

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Kadyrova LY, Gujar V, Burdett V, et al. (2020) Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion. Proceedings of the National Academy of Sciences of the United States of America
Genschel J, Kadyrova LY, Iyer RR, et al. (2017) Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America
Lindahl T, Modrich P, Sancar A. (2016) The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage. Journal of the Association of Genetic Technologists. 42: 37-41
Chen YS, Wu J, Modrich P, et al. (2016) Carboxyl-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCT Domain-containing Protein Mus101 and Fidelity of DNA Segregation. The Journal of Biological Chemistry
Qiu R, Sakato M, Sacho EJ, et al. (2015) MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences of the United States of America. 112: 10914-9
Shao H, Baitinger C, Soderblom EJ, et al. (2014) Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Research. 42: 7104-12
Lindsey-Boltz LA, Kemp MG, Reardon JT, et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. The Journal of Biological Chemistry. 289: 5074-82
Pluciennik A, Burdett V, Baitinger C, et al. (2013) Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12277-82
Liu Y, Kadyrov FA, Modrich P. (2011) PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro Dna Repair. 10: 1145-1153
Tseng Q, Orans J, Hast MA, et al. (2011) Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 947-52
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