Phillip Allen Sharp

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Gene splicing
Website:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1993/sharp-bio.html
Google:
"Phillip Sharp"
Bio:

https://biology.mit.edu/people/phillip_sharp
http://web.mit.edu/sharplab/index.html
http://www.chemheritage.org/discover/collections/oral-histories/details/sharp-phillip-a.aspx
http://www.nasonline.org/member-directory/members/50570.html
The Nobel Prize in Physiology or Medicine 1993 was awarded jointly to Richard J. Roberts and Phillip A. Sharp for their discoveries of split genes

Mean distance: 7.5 (cluster 9)
 
SNBCP
Cross-listing: Cell Biology Tree - DevTree

Parents

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Victor A. Bloomfield grad student 1969 UIUC
 (Physical chemistry of deoxyribonucleic acids and virus)
Norman Davidson post-doc Caltech
James D. Watson post-doc CSHL

Children

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Steve Buratowski grad student MIT (PombeTree)
Stephen Buratowski grad student
Constance L. Cepko grad student MIT (Neurotree)
Daniel J. Donoghue grad student 1979 MIT
Andrew Zachary Fire grad student 1983 MIT
Benjamin M. Shykind grad student 1988-1996 MIT (Neurotree)
Xuebing Wu grad student 2010-2014 MIT (Computational Biology Tree)
Derek Dykxhoorn post-doc MIT (GenetiTree)
Cathie Garnis post-doc MIT (FlyTree)
Hiroshi Handa post-doc MIT (Cell Biology Tree)
Maria Magda Konarska post-doc MIT
Angus Lamond post-doc MIT (Cell Biology Tree)
Andrew MacMilan post-doc MIT
Melissa J. Moore post-doc MIT (Telomere and Telomerase Tree)
Richard Mulligan post-doc MIT
Thomas Tuschl post-doc Whitehead Institute (MIT)
Robert E. Kingston post-doc 1985 MIT
Richard A. Padgett post-doc 1981-1985 MIT
John M. Sedivy post-doc 1984-1988 MIT (Cell Biology Tree)
Jørgen Kjems post-doc 1990-1992 MIT
Benjamin Blencowe post-doc 1992-1998 MIT
Christopher B. Burge post-doc 1997-1999 MIT
Michael Thomas McManus post-doc 2000-2004 MIT
Anthony K. L. Leung post-doc 2004-2011 MIT
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Publications

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Dubbury SJ, Boutz PL, Sharp PA. (2018) CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature. 564: 141-145
Gao A, Shrinivas K, Lepeudry P, et al. (2018) Evolution of weak cooperative interactions for biological specificity. Proceedings of the National Academy of Sciences of the United States of America
Suzuki HI, Spengler RM, Grigelioniene G, et al. (2018) Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nature Genetics
Wang G, Chow RD, Ye L, et al. (2018) Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. Science Advances. 4: eaao5508
Chiu AC, Suzuki HI, Wu X, et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molecular Cell
Murphy PA, Butty VL, Boutz PL, et al. (2018) Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife. 7
Nissim L, Wu MR, Pery E, et al. (2017) Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell
Braun CJ, Stanciu M, Boutz PL, et al. (2017) Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell
Chow RD, Guzman CD, Wang G, et al. (2017) AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience
Suzuki HI, Young RA, Sharp PA. (2017) Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell. 168: 1000-1014.e15
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