Richard T Wheelhouse
Affiliations: | University of Bradford, Bradford, England, United Kingdom |
Area:
Medicinal chemistry, anti cancer drugs, temozolomide, imidazotetrazines, biophysics, NMR, UV, ITC,Google:
"Richard Wheelhouse"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Martyn Symons | grad student | 1985-1989 | University of Leicester (UK) | |
| (PhD advisor) | ||||
| Paul M Cullis | grad student | 1985-1990 | University of Leicester (UK) | |
| (PhD advisor) | ||||
| Malcolm F. G. Stevens | post-doc | 1990-1996 | Nottingham | |
| Laurence H. Hurley | research scientist | UT Austin | ||
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Publications
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| Bahrami K, Kärkkäinen J, Bibi S, et al. (2023) Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106661 |
| Cousin D, Hummersone MG, Bradshaw TD, et al. (2018) Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position. Medchemcomm. 9: 545-553 |
| Allison SJ, Sadiq M, Baronou E, et al. (2018) Corrigendum to "Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands" [Canc. Lett. 403 (2017) 98-107]. Cancer Letters |
| Rice CR, Allison S, Cooke D, et al. (2018) Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells. Angewandte Chemie (International Ed. in English) |
| Allison SJ, Sadiq M, Baronou E, et al. (2017) Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands. Cancer Letters |
| Evans K, Bhamra I, Wheelhouse RT, et al. (2015) Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7278-84 |
| Ramirez YP, Mladek AC, Phillips RM, et al. (2015) Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth. Molecular Cancer Therapeutics. 14: 111-9 |
| Moody CL, Wheelhouse RT. (2014) The medicinal chemistry of imidazotetrazine prodrugs Pharmaceuticals. 7: 797-838 |
| Pletsas D, Garelnabi EA, Li L, et al. (2013) Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53. Journal of Medicinal Chemistry. 56: 7120-32 |
| Tuma ACM, Ramirez Y, Pletsas D, et al. (2013) Abstract 4476: Cytotoxicity of a novel bi-functional temozolomide analog, DP68, is independent of MGMT status in glioblastoma models. Cancer Research. 73: 4476-4476 |