Richard T Wheelhouse

Affiliations: 
University of Bradford, Bradford, England, United Kingdom 
Area:
Medicinal chemistry, anti cancer drugs, temozolomide, imidazotetrazines, biophysics, NMR, UV, ITC,
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"Richard Wheelhouse"
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Parents

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Martyn Symons grad student 1985-1989 University of Leicester (UK)
 (PhD advisor)
Paul M Cullis grad student 1985-1990 University of Leicester (UK)
 (PhD advisor)
Malcolm F. G. Stevens post-doc 1990-1996 Nottingham
Laurence H. Hurley research scientist UT Austin
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Publications

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Cousin D, Hummersone MG, Bradshaw TD, et al. (2018) Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position. Medchemcomm. 9: 545-553
Allison SJ, Sadiq M, Baronou E, et al. (2018) Corrigendum to "Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands" [Canc. Lett. 403 (2017) 98-107]. Cancer Letters
Rice CR, Allison S, Cooke D, et al. (2018) Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells. Angewandte Chemie (International Ed. in English)
Allison SJ, Sadiq M, Baronou E, et al. (2017) Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands. Cancer Letters
Evans K, Bhamra I, Wheelhouse RT, et al. (2015) Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7278-84
Ramirez YP, Mladek AC, Phillips RM, et al. (2015) Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth. Molecular Cancer Therapeutics. 14: 111-9
Moody CL, Wheelhouse RT. (2014) The medicinal chemistry of imidazotetrazine prodrugs Pharmaceuticals. 7: 797-838
Pletsas D, Garelnabi EA, Li L, et al. (2013) Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53. Journal of Medicinal Chemistry. 56: 7120-32
Tuma ACM, Ramirez Y, Pletsas D, et al. (2013) Abstract 4476: Cytotoxicity of a novel bi-functional temozolomide analog, DP68, is independent of MGMT status in glioblastoma models. Cancer Research. 73: 4476-4476
Garelnabi EA, Pletsas D, Li L, et al. (2012) Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR. Acs Medicinal Chemistry Letters. 3: 965-8
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