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Theodore R. Holman

Affiliations: 
Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
lipoxygenase
Website:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=holman
Google:
"Theodore R. Holman"
Mean distance: 8.68
 
SNBCP

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Lawrence Que, Jr. grad student 1991 UMN
 (Physical and spectroscopic studies of bimetallic inorganic complexes)
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Publications

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Warrilow AG, Price CL, Parker JE, et al. (2016) Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports. 6: 27690
Deschamps JD, Ogunsola AF, Jameson JB, et al. (2016) Biochemical/Cellular Characterization and Inhibitor discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry
Karuppagounder SS, Alim I, Khim SJ, et al. (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine. 8: 328ra29
Armstrong MM, Freedman CJ, Jung JE, et al. (2016) A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorganic & Medicinal Chemistry
Jameson JB, Kenyon V, Holman TR. (2015) A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. Analytical Biochemistry. 476: 45-50
Taylor-Fishwick DA, Weaver J, Glenn L, et al. (2015) Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia. 58: 549-57
Tersey SA, Bolanis E, Holman TR, et al. (2015) Minireview: 12-lipoxygenase and islet β-cell dysfunction in diabetes Molecular Endocrinology. 29: 791-800
Mascayano C, Espinosa V, Sepúlveda-Boza S, et al. (2015) Enzymatic studies of isoflavonoids as selective and potent inhibitors of human leukocyte 5-lipo-oxygenase Chemical Biology and Drug Design. 86: 894-901
Jameson JB, Kenyon V, Holman TR. (2015) A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors Analytical Biochemistry. 476: 45-50
Jameson JB, Kantz A, Schultz L, et al. (2014) A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. Plos One. 9: e104094
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