Theodore R. Holman
Affiliations: | Chemistry & Biochemistry | University of California, Santa Cruz, Santa Cruz, CA, United States |
Area:
lipoxygenaseWebsite:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=holmanGoogle:
"Theodore R. Holman"Mean distance: 8.68 | S | N | B | C | P |
Parents
Sign in to add mentor| Lawrence Que | grad student | 1991 | UMN | |
| (Physical and spectroscopic studies of bimetallic inorganic complexes) | ||||
Children
Sign in to add trainee| Wenbo Zhou | grad student | 2006 | UC Santa Cruz |
| Alisha M. Thompson | grad student | 2007 | UC Santa Cruz |
| Aura A. Eroy-Reveles | grad student | 2008 | UC Santa Cruz |
| Daniel J. Stevens | grad student | 2008 | UC Santa Cruz |
| Darren A. Thompson | grad student | 2009 | UC Santa Cruz |
| Aaron T. Wecksler | grad student | 2009 | UC Santa Cruz |
| J. B. Jameson | grad student | 2014 | UC Santa Cruz |
| Kaushik Ghosh | post-doc | 2002-2005 | UC Santa Cruz |
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Publications
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| Deschamps JD, Ogunsola AF, Jameson JB, et al. (2016) Biochemical/Cellular Characterization and Inhibitor discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry |
| Jameson JB, Kenyon V, Holman TR. (2015) A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. Analytical Biochemistry. 476: 45-50 |
| Jameson JB, Kenyon V, Holman TR. (2015) A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors Analytical Biochemistry. 476: 45-50 |
| Jameson JB, Kantz A, Schultz L, et al. (2014) A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. Plos One. 9: e104094 |
| Smyrniotis CJ, Barbour SR, Xia Z, et al. (2014) ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry. 53: 4407-19 |
| Luci DK, Jameson JB, Yasgar A, et al. (2014) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. Journal of Medicinal Chemistry. 57: 495-506 |
| Joshi N, Hoobler EK, Perry S, et al. (2013) Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. Biochemistry. 52: 8026-35 |
| Kenyon V, Rai G, Jadhav A, et al. (2011) Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase Journal of Medicinal Chemistry. 54: 5485-5497 |
| Rai G, Kenyon V, Jadhav A, et al. (2010) Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1 Journal of Medicinal Chemistry. 53: 7392-7404 |
| Wecksler AT, Garcia NK, Holman TR. (2009) Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1 Bioorganic and Medicinal Chemistry. 17: 6534-6539 |