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Daniel A. Harki

Affiliations:

1999-2005

Medicinal Chemistry

University of Minnesota, Twin Cities, Minneapolis, MN

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Parents

Blake R. Peterson	grad student	1999-2005	Penn State
(Chemical synthesis of base-modified ribonucleosides as novel antiviral agents.)
Peter B. Dervan	post-doc	2005-2009	Caltech

Children

Jacob T. Edwards	research assistant	2012-2014	UMN
Stephanie L. Breunig	research assistant	2014-2016	UMN
Caitlin Puro	research assistant	2015-2017	UMN
Dan Wang	grad student	2009-2013	UMN
Timothy E. Andrews	grad student	2010-2013	UMN
Margaret E. Olson	grad student	2010-2015	UMN
Nicholas Struntz	grad student	2009-2016	UMN
John C. Widen	grad student	2011-2017	UMN
Anand Divakaran	grad student	2015-2021	UMN
Constance B Anderson	post-doc		UMN
Frederick A. Meece	post-doc	2009-2010	UMN
Brian R. White	post-doc	2009-2010	UMN
Dennis A. Brown	post-doc	2010-2011	UMN
Tianshun Hu	post-doc	2009-2012	UMN
Aaron M. Kempema	post-doc	2012-2014	UMN
Dibyendu Dana	post-doc	2014-2015	UMN
Ruben Eckermann	post-doc	2016-2017	UMN

Collaborators

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Publications

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Divakaran A, Harki DA, Pomerantz WCK. (2023) Recent progress and structural analyses of domain-selective BET inhibitors. Medicinal Research Reviews
Divakaran A, Scholtz CR, Zahid H, et al. (2022) Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. Acs Medicinal Chemistry Letters. 13: 1621-1627
Moghadasi SA, Esler MA, Otsuka Y, et al. (2022) Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M/3CL in Living Cells. Mbio. e0078422
Ghani LA, Yusenko MV, Frank D, et al. (2022) A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells. Cancer Letters
Cui H, Divakaran A, Hoell ZJ, et al. (2022) A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. Journal of Medicinal Chemistry
Cui H, Carlson AS, Schleiff MA, et al. (2021) 4-Methyl-1,2,3-Triazoles as -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. Journal of Medicinal Chemistry
Jackson PA, Schares HAM, Jones KFM, et al. (2020) Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. Journal of Medicinal Chemistry
Pomerantz WCK, Cui H, Divakaran A, et al. (2020) Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement. Angewandte Chemie (International Ed. in English)
Passow KT, Antczak NM, Sturla SJ, et al. (2020) Synthesis of 4-Cyanoindole Nucleosides, 4-Cyanoindole-2'-Deoxyribonucleoside-5'-Triphosphate (4CIN-TP), and Enzymatic Incorporation of 4CIN-TP into DNA. Current Protocols in Nucleic Acid Chemistry. 80: e101
Kvach MV, Barzak FM, Harjes S, et al. (2019) Differential inhibition of APOBEC3 DNA-mutator isozymes by fluoro- versus non-fluoro-substituted 2'-deoxyzebularine embedded in single-stranded DNA. Chembiochem : a European Journal of Chemical Biology

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