Daniel A. Harki

Affiliations: 
1999-2005 Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
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Parents

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Blake R. Peterson grad student 1999-2005 Penn State
 (Chemical synthesis of base-modified ribonucleosides as novel antiviral agents.)
Peter B. Dervan post-doc 2005-2009 Caltech

Children

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Jacob T. Edwards research assistant 2012-2014 UMN
Stephanie L. Breunig research assistant 2014-2016 UMN
Caitlin Puro research assistant 2015-2017 UMN
Dan Wang grad student 2009-2013 UMN
Timothy E. Andrews grad student 2010-2013 UMN
Margaret E. Olson grad student 2010-2015 UMN
Nicholas Struntz grad student 2009-2016 UMN
John C. Widen grad student 2011-2017 UMN
Frederick A. Meece post-doc 2009-2010 UMN
Brian R. White post-doc 2009-2010 UMN
Dennis A. Brown post-doc 2010-2011 UMN
Tianshun Hu post-doc 2009-2012 UMN
Aaron M. Kempema post-doc 2012-2014 UMN
Dibyendu Dana post-doc 2014-2015 UMN
Ruben Eckermann post-doc 2016-2017 UMN
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Publications

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Kvach MV, Barzak FM, Harjes S, et al. (2018) Inhibiting APOBEC3 activity with single-stranded DNA containing 2'-deoxyzebularine analogs. Biochemistry
Divakaran A, Talluri SK, Ayoub AM, et al. (2018) Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of Medicinal Chemistry
Wagner JR, Demir O, Carpenter MA, et al. (2018) Determinants of Oligonucleotide Selectivity of APOBEC3B. Journal of Chemical Information and Modeling
Naumann JA, Widen JC, Jonart LA, et al. (2018) SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy. Bioconjugate Chemistry
Widen JC, Kempema AM, Baur JW, et al. (2018) Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Chemmedchem
Olson ME, Harris RS, Harki DA. (2017) APOBEC Enzymes as Targets for Virus and Cancer Therapy. Cell Chemical Biology
Dulin D, Arnold JJ, van Laar T, et al. (2017) Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers. Cell Reports. 21: 1063-1076
Widen JC, Kempema AM, Villalta PW, et al. (2017) Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile. Acs Chemical Biology. 12: 102-113
Breunig SL, Olson ME, Harki DA. (2016) Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles. Tetrahedron Letters. 57: 4056-4060
Jackson PA, Widen JC, Harki DA, et al. (2016) Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry
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