Dominico Vigil, Ph.D. - Publications

2005 University of California, San Diego, La Jolla, CA 
Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Burke JP, Bian Z, Shaw S, Zhao B, Goodwin CM, Belmar J, Browning CF, Vigil D, Friberg A, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW. Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. Journal of Medicinal Chemistry. 58: 3794-805. PMID 25844895 DOI: 10.1021/jm501984f  0.48
2013 Vigil D, Der CJ. Inhibitors of the ROCK serine/threonine kinases: key effectors of the RhoA small GTPase. The Enzymes. 33: 193-212. PMID 25033806 DOI: 10.1016/B978-0-12-416749-0.00009-9  0.48
2013 Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. Journal of Medicinal Chemistry. 56: 15-30. PMID 23244564 DOI: 10.1021/jm301448p  0.48
2012 Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Research. 72: 5338-47. PMID 22942252 DOI: 10.1158/0008-5472.CAN-11-2373  0.48
2011 Stevens EV, Banet N, Onesto C, Plachco A, Alan JK, Nikolaishvili-Feinberg N, Midkiff BR, Kuan PF, Liu J, Miller CR, Vigil D, Graves LM, Der CJ. RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Small Gtpases. 2: 202-210. PMID 22145092 DOI: 10.4161/sgtp.2.4.17795  0.48
2010 Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nature Reviews. Cancer. 10: 842-57. PMID 21102635 DOI: 10.1038/nrc2960  0.48
2010 Vigil D, Martin TD, Williams F, Yeh JJ, Campbell SL, Der CJ. Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. The Journal of Biological Chemistry. 285: 34729-40. PMID 20801877 DOI: 10.1074/jbc.M110.116756  0.48
2009 Kim TY, Vigil D, Der CJ, Juliano RL. Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Reviews. 28: 77-83. PMID 19221866 DOI: 10.1007/s10555-008-9167-2  0.48
2009 Yang XY, Guan M, Vigil D, Der CJ, Lowy DR, Popescu NC. p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. Oncogene. 28: 1401-9. PMID 19151751 DOI: 10.1038/onc.2008.498  0.48
2008 Mokhtari T, Chakrabarti A, Sorensen CM, Cheng CY, Vigil D. The effect of shear on colloidal aggregation and gelation studied using small-angle light scattering. Journal of Colloid and Interface Science. 327: 216-23. PMID 18771777 DOI: 10.1016/j.jcis.2008.08.017  0.48
2006 Rho BS, Hung LW, Holton JM, Vigil D, Kim SI, Park MS, Terwilliger TC, Pédelacq JD. Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis. Journal of Molecular Biology. 361: 850-63. PMID 16884737 DOI: 10.1016/j.jmb.2006.05.076  0.48
2006 Kim C, Vigil D, Anand G, Taylor SS. Structure and dynamics of PKA signaling proteins. European Journal of Cell Biology. 85: 651-4. PMID 16647784 DOI: 10.1016/j.ejcb.2006.02.004  0.48
2006 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. Journal of Molecular Biology. 357: 880-9. PMID 16460759 DOI: 10.1016/j.jmb.2006.01.006  0.48
2006 Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor SS. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Science : a Publication of the Protein Society. 15: 113-21. PMID 16322564 DOI: 10.1110/ps.051723606  0.48
2005 Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Dynamics of signaling by PKA. Biochimica Et Biophysica Acta. 1754: 25-37. PMID 16214430 DOI: 10.1016/j.bbapap.2005.08.024  0.48
2005 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. The Journal of Biological Chemistry. 280: 35521-7. PMID 16109722 DOI: 10.1074/jbc.M506769200  0.48
2004 Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 43: 5629-36. PMID 15134437 DOI: 10.1021/bi0499157  0.48
2004 Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. Journal of Molecular Biology. 337: 1183-94. PMID 15046986 DOI: 10.1016/j.jmb.2004.02.028  0.48
2004 Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. The Journal of Biological Chemistry. 279: 19084-90. PMID 14985329 DOI: 10.1074/jbc.M313405200  0.48
2001 Vigil D, Gallagher SC, Trewhella J, García AE. Functional dynamics of the hydrophobic cleft in the N-domain of calmodulin. Biophysical Journal. 80: 2082-92. PMID 11325712 DOI: 10.1016/S0006-3495(01)76182-6  0.48
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