Nick P. Franks - Publications

Affiliations: 
Imperial College, London, London, England, United Kingdom 
Area:
Biophysics, Anesthesia Mechanisms, Structural Biology

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G. Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. British Journal of Pharmacology. PMID 27459129 DOI: 10.1111/bph.13566  0.6
2015 Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. The Lancet. Neurology. PMID 26708675 DOI: 10.1016/S1474-4422(15)00347-6  0.6
2015 Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G. Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular Pharmacology. 88: 736-45. PMID 26206487 DOI: 10.1124/mol.115.100347  0.6
2015 Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 87: 164-78. PMID 26094607 DOI: 10.1016/j.neuron.2015.06.003  0.6
2015 Zhang Z, Ferretti V, Güntan ?, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. Nature Neuroscience. 18: 553-61. PMID 25706476 DOI: 10.1038/nn.3957  0.6
2015 Franks NP. Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors. Anesthesiology. 122: 787-94. PMID 25575161 DOI: 10.1097/ALN.0000000000000588  0.6
2015 MacKenzie G, Franks NP, Brickley SG. Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels. PflüGers Archiv : European Journal of Physiology. 467: 989-99. PMID 25482670 DOI: 10.1007/s00424-014-1660-6  0.6
2015 Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W. The role of K₂p channels in anaesthesia and sleep. PflüGers Archiv : European Journal of Physiology. 467: 907-16. PMID 25482669 DOI: 10.1007/s00424-014-1654-4  0.6
2015 Campos-Pires R, Armstrong SP, Sebastiani A, Luh C, Gruss M, Radyushkin K, Hirnet T, Werner C, Engelhard K, Franks NP, Thal SC, Dickinson R. Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury. Critical Care Medicine. 43: 149-58. PMID 25188549 DOI: 10.1097/CCM.0000000000000624  0.6
2014 Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W. Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture. Current Biology : Cb. 24: 2838-44. PMID 25454592 DOI: 10.1016/j.cub.2014.10.019  0.6
2014 Bertaccini EJ, Dickinson R, Trudell JR, Franks NP. Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics. Acs Chemical Neuroscience. 5: 1246-52. PMID 25340635 DOI: 10.1021/cn500172e  0.6
2014 Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP. Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13326-35. PMID 25274812 DOI: 10.1523/JNEUROSCI.1519-14.2014  0.6
2014 Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP. Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep. The European Journal of Neuroscience. 40: 2311-9. PMID 24674448 DOI: 10.1111/ejn.12570  0.6
2013 Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nature Chemical Biology. 9: 715-20. PMID 24056400 DOI: 10.1038/nchembio.1340  0.6
2013 Harris K, Armstrong SP, Campos-Pires R, Kiru L, Franks NP, Dickinson R. Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site. Anesthesiology. 119: 1137-48. PMID 23867231 DOI: 10.1097/ALN.0b013e3182a2a265  0.6
2013 Franks NP. The unfolding story of how general anesthetics act The Wondrous Story of Anesthesia. 597-608. DOI: 10.1007/978-1-4614-8441-7_45  0.6
2012 Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 117: 1262-75. PMID 23143806 DOI: 10.1097/ALN.0b013e3182746b81  0.6
2012 Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13062-75. PMID 22993424 DOI: 10.1523/JNEUROSCI.2931-12.2012  0.6
2012 Armstrong SP, Banks PJ, McKitrick TJ, Geldart CH, Edge CJ, Babla R, Simillis C, Franks NP, Dickinson R. Identification of two mutations (F758W and F758Y) in the N-methyl-D-aspartate receptor glycine-binding site that selectively prevent competitive inhibition by xenon without affecting glycine binding. Anesthesiology. 117: 38-47. PMID 22634870 DOI: 10.1097/ALN.0b013e31825ada2e  0.6
2012 Houston CM, McGee TP, Mackenzie G, Troyano-Cuturi K, Rodriguez PM, Kutsarova E, Diamanti E, Hosie AM, Franks NP, Brickley SG. Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3887-97. PMID 22423109 DOI: 10.1523/JNEUROSCI.5406-11.2012  0.6
2011 Franks NP, Zecharia AY. Sleep and general anesthesia. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 58: 139-48. PMID 21170623 DOI: 10.1007/s12630-010-9420-3  0.6
2010 Dickinson R, Franks NP. Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection. Critical Care (London, England). 14: 229. PMID 20836899 DOI: 10.1186/cc9051  0.6
2010 Banks P, Franks NP, Dickinson R. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia. Anesthesiology. 112: 614-22. PMID 20124979 DOI: 10.1097/ALN.0b013e3181cea398  0.6
2009 Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP. An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proceedings of the National Academy of Sciences of the United States of America. 106: 17546-51. PMID 19805135 DOI: 10.1073/pnas.0907228106  0.6
2009 Zecharia AY, Franks NP. General anesthesia and ascending arousal pathways. Anesthesiology. 111: 695-6. PMID 19707121 DOI: 10.1097/ALN.0b013e3181b061bc  0.6
2009 Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2177-87. PMID 19228970 DOI: 10.1523/JNEUROSCI.4997-08.2009  0.6
2008 Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nature Reviews. Neuroscience. 9: 370-86. PMID 18425091 DOI: 10.1038/nrn2372  0.6
2008 Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. The Journal of Comparative Neurology. 508: 648-62. PMID 18383504 DOI: 10.1002/cne.21685  0.6
2008 Coburn M, Maze M, Franks NP. The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Critical Care Medicine. 36: 588-95. PMID 18216607 DOI: 10.1097/01.CCM.0B013E3181611F8A6  0.6
2007 Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology. 107: 756-67. PMID 18073551 DOI: 10.1097/01.anes.0000287061.77674.71  0.6
2007 Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP. Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. The Journal of Biological Chemistry. 282: 20977-90. PMID 17548360 DOI: 10.1074/jbc.M610692200  0.6
2007 Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology. 106: 746-53. PMID 17413912 DOI: 10.1097/01.anes.0000264762.48920.80  0.6
2007 Bright DP, Adham SD, Lemaire LC, Benavides R, Gruss M, Taylor GW, Smith EH, Franks NP. Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel. The Journal of Biological Chemistry. 282: 12038-47. PMID 17311911 DOI: 10.1074/jbc.M700479200  0.6
2007 Bertaccini EJ, Trudell JR, Franks NP. The common chemical motifs within anesthetic binding sites. Anesthesia and Analgesia. 104: 318-24. PMID 17242087 DOI: 10.1213/01.ane.0000253029.67331.8d  0.6
2007 Martin JL, Ma D, Hossain M, Xu J, Sanders RD, Franks NP, Maze M. Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat. British Journal of Anaesthesia. 98: 236-40. PMID 17210733 DOI: 10.1093/bja/ael340  0.6
2006 Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K. The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesthesia and Analgesia. 103: 1459-63. PMID 17122223 DOI: 10.1213/01.ane.0000247792.03959.f1  0.6
2006 Franks NP, Benavides R, Maze M. Air bubble growth in water [2] Anesthesiology. 105: 1059-1060. PMID 17065904  0.6
2006 Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M. Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neuroscience Letters. 409: 128-33. PMID 17052852 DOI: 10.1016/j.neulet.2006.09.020  0.6
2006 Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M. Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Anesthesiology. 104: 458-65. PMID 16508392 DOI: 10.1097/00000542-200603000-00012  0.6
2006 Benavides R, Maze M, Franks NP. Expansion of gas bubbles by nitrous oxide and xenon. Anesthesiology. 104: 299-302. PMID 16436849 DOI: 10.1097/00000542-200602000-00015  0.6
2006 Franks NP. Molecular targets underlying general anaesthesia. British Journal of Pharmacology. 147: S72-81. PMID 16402123 DOI: 10.1038/sj.bjp.0706441  0.6
2006 Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M. Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 199-208. PMID 16034370 DOI: 10.1038/sj.jcbfm.9600184  0.6
2006 Nelson LE, Franks NP, Maze M. The mechanistic relationship between NREM sleep and anesthesia Sleep and Sleep Disorders: a Neuropsychopharmacological Approach. 43-52. DOI: 10.1007/0-387-27682-3_6  0.6
2005 Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Annals of Neurology. 58: 182-93. PMID 16049939 DOI: 10.1002/ana.20547  0.6
2005 White IL, Franks NP, Dickinson R. Effects of isoflurane and xenon on Ba2+-currents mediated by N-type calcium channels. British Journal of Anaesthesia. 94: 784-90. PMID 15778267 DOI: 10.1093/bja/aei126  0.6
2005 Caley AJ, Gruss M, Franks NP. The effects of hypoxia on the modulation of human TREK-1 potassium channels. The Journal of Physiology. 562: 205-12. PMID 15486012 DOI: 10.1113/jphysiol.2004.076240  0.6
2005 Peterson BK, Valenzuela CA, Martin JCS, Franks NP. Adsorption simulations and biology: Grand canonical Monte Carlo calculations of binding locations, occupancy, and free energies of xenon in comp and mutant phage T4 lysozyme L99a Aiche Annual Meeting, Conference Proceedings. 1834.  0.6
2004 Franks NP, Honoré E. The TREK K2P channels and their role in general anaesthesia and neuroprotection. Trends in Pharmacological Sciences. 25: 601-8. PMID 15491783 DOI: 10.1016/j.tips.2004.09.003  0.6
2004 Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. European Journal of Pharmacology. 502: 87-97. PMID 15464093 DOI: 10.1016/j.ejphar.2004.08.044  0.6
2004 Gruss M, Mathie A, Lieb WR, Franks NP. The two-pore-domain K(+) channels TREK-1 and TASK-3 are differentially modulated by copper and zinc. Molecular Pharmacology. 66: 530-7. PMID 15322244 DOI: 10.1124/mol.66.3.  0.6
2004 Abraini JH, David HN, Nicole O, MacKenzie ET, Buisson A, Lemaire M. Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration. Anesthesiology. 101: 260-1; author reply . PMID 15220810  0.6
2004 Franks NP, Lieb WR. Seeing the light: protein theories of general anesthesia. 1984. Anesthesiology. 101: 235-7. PMID 15220795  0.6
2004 Nelson LE, Franks NP, Maze M. Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Anesthesiology. 100: 1341-2. PMID 15166550 DOI: 10.1097/00000542-200406000-00003  0.6
2004 Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M. Xenon exerts age-independent antinociception in Fischer rats. Anesthesiology. 100: 1313-8. PMID 15114234 DOI: 10.1097/00000542-200405000-00040  0.6
2004 Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Molecular Pharmacology. 65: 443-52. PMID 14742687 DOI: 10.1124/mol.65.2.443  0.6
2004 Plested AJ, Wildman SS, Lieb WR, Franks NP. Determinants of the sensitivity of AMPA receptors to xenon. Anesthesiology. 100: 347-58. PMID 14739810 DOI: 10.1097/00000542-200402000-00025  0.6
2003 Sanders RD, Franks NP, Maze M. Xenon: no stranger to anaesthesia. British Journal of Anaesthesia. 91: 709-17. PMID 14570795 DOI: 10.1093/bja/aeg232  0.6
2003 Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP. The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology. 99: 876-81. PMID 14508320 DOI: 10.1097/00000542-200310000-00020  0.6
2003 Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M. Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Anesthesiology. 99: 748-51. PMID 12960563 DOI: 10.1097/00000542-200309000-00034  0.6
2003 Dickinson R, Awaiz S, Whittington MA, Lieb WR, Franks NP. The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro. Neuropharmacology. 44: 864-72. PMID 12726818 DOI: 10.1016/S0028-3908(03)00083-2  0.6
2003 Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 98: 690-8. PMID 12606913 DOI: 10.1097/00000542-200303000-00017  0.6
2003 Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 98: 428-36. PMID 12552203 DOI: 10.1097/00000542-200302000-00024  0.6
2002 Ma D, Wilhelm S, Maze M, Franks NP. Neuroprotective and neurotoxic properties of the 'inert' gas, xenon. British Journal of Anaesthesia. 89: 739-46. PMID 12393773 DOI: 10.1093/bja/aef258  0.6
2002 Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nature Neuroscience. 5: 979-84. PMID 12195434 DOI: 10.1038/nn913  0.6
2002 Wilhelm S, Ma D, Maze M, Franks NP. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 96: 1485-91. PMID 12170064 DOI: 10.1097/00000542-200206000-00031  0.6
2002 Dickinson R, de Sousa SL, Lieb WR, Franks NP. Selective synaptic actions of thiopental and its enantiomers. Anesthesiology. 96: 884-92. PMID 11964596 DOI: 10.1097/00000542-200204000-00016  0.6
2002 Downie DL, Vicente-Agullo F, Campos-Caro A, Bushell TJ, Lieb WR, Franks NP. Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 277: 10367-73. PMID 11741933 DOI: 10.1074/jbc.M107847200  0.6
2002 Franks NP, Maze M. Molecular and cellular actions of xenon - Evidence from in vitro studies Journal Fur Anasthesie Und Intensivbehandlung. 9: 36.  0.6
2002 Maze M, Franks N. Neuroprotective and neurotoxic effects of xenon in vivo Journal Fur Anasthesie Und Intensivbehandlung. 9: 94.  0.6
2001 Eckenhoff RG, Johansson JS, Eger EI, Sonner JM, Dilger JP, Fisher DM, Evers A, Franks NP, Harris RA, Kendig JJ, Lieb WR, Yamakura T. What are "relevant" concentrations? [6] (multiple letters) Anesthesiology. 95: 1537-1539. PMID 11767771  0.6
2001 Eger EI, Fisher DM, Dilger JP, Sonner JM, Evers A, Franks NP, Harris RA, Kendig JJ, Lieb WR, Yamakura T. Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology. 94: 915-21. PMID 11388545  0.6
2001 Dickinson R, De Sousa SLM, Lieb WR, Franks NP. The effects of xenon on NMDA and GABAA receptors Journal Fur Anasthesie Und Intensivbehandlung. 8: 34-36.  0.6
2000 Dickinson R, White I, Lieb WR, Franks NP. Stereoselective loss of righting reflex in rats by isoflurane. Anesthesiology. 93: 837-43. PMID 10969319  0.6
2000 Downie DL, Franks NP, Lieb WR. Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors. Anesthesiology. 93: 774-83. PMID 10969311  0.6
2000 Bhattacharya AA, Curry S, Franks NP. Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. The Journal of Biological Chemistry. 275: 38731-8. PMID 10940303 DOI: 10.1074/jbc.M005460200  0.6
2000 de Sousa SL, Dickinson R, Lieb WR, Franks NP. Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology. 92: 1055-66. PMID 10754626  0.6
2000 Franks NP. What makes xenon an anesthetic gas? Applied Cardiopulmonary Pathophysiology. 9: 56.  0.6
1999 Curry S, Brick P, Franks NP. Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochimica Et Biophysica Acta. 1441: 131-40. PMID 10570241 DOI: 10.1016/S1388-1981(99)00148-1  0.6
1999 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Preparation of barbiturate optical isomers and their effects on GABA(A) receptors. Anesthesiology. 90: 1714-22. PMID 10360871 DOI: 10.1097/00000542-199906000-00029  0.6
1999 Franks NP, Lieb WR. Background K+ channels: an important target for volatile anesthetics? Nature Neuroscience. 2: 395-6. PMID 10321238 DOI: 10.1038/8054  0.6
1999 Jenkins A, Franks NP, Lieb WR. Effects of temperature and volatile anesthetics on GABA(A) receptors. Anesthesiology. 90: 484-91. PMID 9952156 DOI: 10.1097/00000542-199902000-00024  0.6
1998 Franks NP, Lieb WR. Which molecular targets are most relevant to general anaesthesia? Toxicology Letters. 100: 1-8. PMID 10049127 DOI: 10.1016/S0378-4274(98)00158-1  0.6
1998 Franks NP, Dickinson R, de Sousa SL, Hall AC, Lieb WR. How does xenon produce anaesthesia? Nature. 396: 324. PMID 9845069 DOI: 10.1038/24525  0.6
1998 Franks NP, Jenkins A, Conti E, Lieb WR, Brick P. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophysical Journal. 75: 2205-11. PMID 9788915 DOI: 10.1016/S0006-3495(98)77664-7  0.6
1998 Lopes CM, Franks NP, Lieb WR. Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones. British Journal of Pharmacology. 125: 309-18. PMID 9786503 DOI: 10.1038/sj.bjp.0702069  0.6
1998 Curry S, Mandelkow H, Brick P, Franks N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nature Structural Biology. 5: 827-35. PMID 9731778 DOI: 10.1038/1869  0.6
1998 Franks NP, Lieb WR. A serious target for laughing gas. Nature Medicine. 4: 383-4. PMID 9546774 DOI: 10.1038/nm0498-383  0.6
1998 Tomlin SL, Jenkins A, Lieb WR, Franks NP. Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology. 88: 708-17. PMID 9523815 DOI: 10.1097/00000542-199803000-00022  0.6
1997 Franks NP, Lieb WR. Inhibitory synapses. Anaesthetics set their sites on ion channels. Nature. 389: 334-5. PMID 9311772 DOI: 10.1038/38614  0.6
1997 Violet JM, Downie DL, Nakisa RC, Lieb WR, Franks NP. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics. Anesthesiology. 86: 866-74. PMID 9105231 DOI: 10.1097/00000542-199704000-00017  0.6
1997 Franks NP, Lieb WR. Selectivity of general anesthetics: a new dimension. Nature Medicine. 3: 377-8. PMID 9095164 DOI: 10.1038/nm0497-377  0.6
1996 Conti E, Lloyd LF, Akins J, Franks NP, Brick P. Crystallization and preliminary diffraction studies of firefly luciferase from Photinus pyralis. Acta Crystallographica. Section D, Biological Crystallography. 52: 876-8. PMID 15299657 DOI: 10.1107/S0907444996002405  0.6
1996 Conti E, Franks NP, Brick P. Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure (London, England : 1993). 4: 287-98. PMID 8805533  0.6
1996 Downie DL, Hall AC, Lieb WR, Franks NP. Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. British Journal of Pharmacology. 118: 493-502. PMID 8762070  0.6
1996 Jenkins A, Franks NP, Lieb WR. Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. British Journal of Pharmacology. 117: 1507-15. PMID 8730747  0.6
1996 Franks NP, Lieb WR. An anesthetic-sensitive superfamily of neurotransmitter-gated ion channels. Journal of Clinical Anesthesia. 8: 3S-7S. PMID 8695112  0.6
1996 Franks NP, Lieb WR. Temperature dependence of the potency of volatile general anesthetics: implications for in vitro experiments. Anesthesiology. 84: 716-20. PMID 8659800 DOI: 10.1097/00000542-199603000-00027  0.6
1995 Dickinson R, Lieb WR, Franks NP. The effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptor. British Journal of Pharmacology. 116: 2949-56. PMID 8680729  0.6
1995 McKenzie D, Franks NP, Lieb WR. Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. British Journal of Pharmacology. 115: 275-82. PMID 7670729  0.6
1994 Hall AC, Lieb WR, Franks NP. Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. Anesthesiology. 81: 117-23. PMID 8042779  0.6
1994 Hall AC, Lieb WR, Franks NP. Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor. British Journal of Pharmacology. 112: 906-10. PMID 7921619  0.6
1994 Dickinson R, Franks NP, Lieb WR. Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility? Biophysical Journal. 66: 2019-23. PMID 7521228 DOI: 10.1016/S0006-3495(94)80994-4  0.6
1994 Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature. 367: 607-14. PMID 7509043 DOI: 10.1038/367607a0  0.6
1993 Dickinson R, Franks NP, Lieb WR. Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase. Biophysical Journal. 64: 1264-71. PMID 8494981 DOI: 10.1016/S0006-3495(93)81491-7  0.6
1993 Dickinson R, Smith EH, Franks NP, Lieb WR. Synthesis and use of the n-bromododecane-1,12-diols as conformational probes for general anesthetic target sites. Journal of Medicinal Chemistry. 36: 111-8. PMID 8421276  0.6
1993 Franks NP, Abraham MH, Lieb WR. Molecular organization of liquid n-octanol: an X-ray diffraction analysis. Journal of Pharmaceutical Sciences. 82: 466-70. PMID 8360823 DOI: 10.1002/jps.2600820507  0.6
1993 Hall AC, Tibbs GR, Dolly JO, Lieb WR, Franks NP. A simple method for recording single-channel activity from synaptic plasma membranes. Journal of Neuroscience Methods. 49: 81-91. PMID 8271834 DOI: 10.1016/0165-0270(93)90111-4  0.6
1993 Franks NP, Lieb WR. Selective actions of volatile general anaesthetics at molecular and cellular levels. British Journal of Anaesthesia. 71: 65-76. PMID 7688242  0.6
1992 McKenzie JD, Calow P, Clyde J, Miles A, Dickinson R, Lieb WR, Franks NP. Effects of temperature on the anaesthetic potency of halothane, enflurane and ethanol in Daphnia magna (Cladocera: Crustacea). Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 101: 15-9. PMID 1350959 DOI: 10.1016/0742-8413(92)90193-B  0.6
1991 Franks NP, Lieb WR. Selective effects of volatile general anesthetics on identified neurons. Annals of the New York Academy of Sciences. 625: 54-70. PMID 2058905  0.6
1991 Curry S, Moss GW, Dickinson R, Lieb WR, Franks NP. Probing the molecular dimensions of general anaesthetic target sites in tadpoles (Xenopus laevis) and model systems using cycloalcohols. British Journal of Pharmacology. 102: 167-73. PMID 2043920  0.6
1991 Moss GW, Franks NP, Lieb WR. Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase. Proceedings of the National Academy of Sciences of the United States of America. 88: 134-8. PMID 1986359 DOI: 10.1073/pnas.88.1.134  0.6
1991 Moss GW, Curry S, Franks NP, Lieb WR. Mapping the polarity profiles of general anesthetic target sites using n-alkane-(alpha, omega)-diols. Biochemistry. 30: 10551-7. PMID 1931978  0.6
1991 Franks NP, Lieb WR. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science (New York, N.Y.). 254: 427-30. PMID 1925602  0.6
1991 Franks NP, Lieb WR. Effects of physiologically relevant pressures of helium on the structure of cholesterol-containing lipid bilayers. A neutron diffraction study. Biophysical Journal. 60: 498-501. PMID 1912283 DOI: 10.1016/S0006-3495(91)82076-8  0.6
1991 Franks NP, Lieb WR. An anaesthetic-activated potassium channel. Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 1: 197-202. PMID 1845537  0.6
1991 Abraham MH, Lieb WR, Franks NP. Role of hydrogen bonding in general anesthesia. Journal of Pharmaceutical Sciences. 80: 719-24. PMID 1791528 DOI: 10.1002/jps.2600800802  0.6
1991 Moss GW, Lieb WR, Franks NP. Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal. Biophysical Journal. 60: 1309-14. PMID 1777560 DOI: 10.1016/S0006-3495(91)82168-3  0.6
1990 Curry S, Lieb WR, Franks NP. Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity. Biochemistry. 29: 4641-52. PMID 2372547  0.6
1990 Franks NP, Lieb WR. Mechanisms of general anesthesia. Environmental Health Perspectives. 87: 199-205. PMID 2269226  0.6
1988 Franks NP, Lieb WR. Volatile general anaesthetics activate a novel neuronal K+ current. Nature. 333: 662-4. PMID 2453807 DOI: 10.1038/333662a0  0.6
1987 Franks NP, Lieb WR. Neuron membranes: anaesthetics on the mind. Nature. 328: 113-4. PMID 3600786 DOI: 10.1038/328113a0  0.6
1987 Franks NP, Lieb WR. Are the biological effects of ethanol due to primary interactions with lipids or with proteins? Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 1: 139-45. PMID 3426670  0.6
1987 Franks NP, Lieb WR. What is the molecular nature of general anaesthetic target sites? Trends in Pharmacological Sciences. 8: 169-174. DOI: 10.1016/0165-6147(87)90160-X  0.6
1986 Elliott JR, Haydon DA. Mapping of general anaesthetic target sites. Nature. 319: 77-8. PMID 3941742 DOI: 10.1038/319077a0  0.6
1986 Franks NP, Lieb WR. The pharmacology of simple molecules. Archives of Toxicology. Supplement. = Archiv FüR Toxikologie. Supplement. 9: 27-37. PMID 3545147  0.6
1986 Franks NP, Lieb WR. Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia. Proceedings of the National Academy of Sciences of the United States of America. 83: 5116-20. PMID 3460084  0.6
1986 Franks NP, Lieb WR. Mapping of general anaesthetic target sites (reply) Nature. 319: 78. DOI: 10.1038/319078a0  0.6
1985 Franks NP, Lieb WR. Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature. 316: 349-51. PMID 4022125  0.6
1985 MacNaughtan W, Snook KA, Caspi E, Franks NP. An X-ray diffraction analysis of oriented lipid multilayers containing basic proteins. Biochimica Et Biophysica Acta. 818: 132-48. PMID 2411290 DOI: 10.1016/0005-2736(85)90556-5  0.6
1985 Franks NP, Lieb WR. The firefly throws light on anaesthesia Chemistry in Britain. 21: 919-921.  0.6
1984 Franks NP, Lieb WR. Do general anaesthetics act by competitive binding to specific receptors? Nature. 310: 599-601. PMID 6462249  0.6
1982 Franks NP, Melchior V, Kirshner DA, Caspar DL. Structure of myelin lipid bilayers. Changes during maturation. Journal of Molecular Biology. 155: 133-53. PMID 7077673 DOI: 10.1016/0022-2836(82)90441-7  0.6
1982 Franks NP, Lieb WR. Molecular mechanisms of general anaesthesia. Nature. 300: 487-93. PMID 6755267  0.6
1981 Franks NP, Lieb WR. Is membrane expansion relevant to anaesthesia? Nature. 292: 248-51. PMID 7254317  0.6
1981 Franks NP, Levine YK. Low-angle x-ray diffraction. Molecular Biology, Biochemistry, and Biophysics. 31: 437-87. PMID 7015110  0.6
1980 Franks NP, Lieb WR. Rapid movement of molecules across membranes. Measurement of the permeability coefficient of water using neutron diffraction. Journal of Molecular Biology. 141: 43-61. PMID 7431400 DOI: 10.1016/S0022-2836(80)80028-3  0.6
1979 Franks NP, Lieb WR. The structure of lipid bilayers and the effects of general anaesthetics. An x-ray and neutron diffraction study. Journal of Molecular Biology. 133: 469-500. PMID 537057 DOI: 10.1016/0022-2836(79)90403-0  0.6
1978 Franks NP, Arunachalam T, Caspi E. A direct method for determination of membrane electron density profiles on an absolute scale. Nature. 276: 530-2. PMID 723939 DOI: 10.1038/276530a0  0.6
1978 Franks NP, Lieb WR. Where do general anaesthetics act? Nature. 274: 339-42. PMID 672957  0.6
1976 Worcester DL, Franks NP. Structural analysis of hydrated egg lecithin and cholesterol bilayers. II. Neutrol diffraction. Journal of Molecular Biology. 100: 359-78. PMID 943549 DOI: 10.1016/S0022-2836(76)80068-X  0.6
1976 Franks NP. Structural analysis of hydrated egg lecithin and cholesterol bilayers. I. X-ray diffraction. Journal of Molecular Biology. 100: 345-58. PMID 943548 DOI: 10.1016/S0022-2836(76)80067-8  0.6
1976 Franks NP. Myelin structure Nature. 259: 447. DOI: 10.1038/259447b0  0.6
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