Timothy A. Garrow - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Nutrition, Animal Physiology Biology, Biochemistry

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Ganu RS, Ishida Y, Koutmos M, Kolokotronis SO, Roca AL, Garrow TA, Schook LB. Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes. Plos One. 10: e0134084. PMID 26213999 DOI: 10.1371/journal.pone.0134084  1
2014 Mládková J, Hladílková J, Diamond CE, Tryon K, Yamada K, Garrow TA, Jungwirth P, Koutmos M, Jiráček J. Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins. 82: 2552-64. PMID 24895213 DOI: 10.1002/prot.24619  1
2013 Ganu R, Garrow T, Koutmos M, Rund L, Schook LB. Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism. Gene. 529: 228-37. PMID 23948084 DOI: 10.1016/j.gene.2013.07.103  1
2013 Pícha J, Vaněk V, Buděšínský M, Mládková J, Garrow TA, Jiráček J. The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase. European Journal of Medicinal Chemistry. 65: 256-75. PMID 23727536 DOI: 10.1016/j.ejmech.2013.04.039  1
2012 Lee MB, Kooistra M, Zhang B, Slow S, Fortier AL, Garrow TA, Lever M, Trasler JM, Baltz JM. Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development. The Journal of Biological Chemistry. 287: 33094-103. PMID 22847001 DOI: 10.1074/jbc.M112.365478  1
2012 Mládková J, VanÄ›k V, Buděšínský M, Elbert T, Demianová Z, Garrow TA, Jiráček J. Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2. Journal of Medicinal Chemistry. 55: 6822-31. PMID 22775318 DOI: 10.1021/jm300571h  1
2011 Teng YW, Mehedint MG, Garrow TA, Zeisel SH. Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. The Journal of Biological Chemistry. 286: 36258-67. PMID 21878621 DOI: 10.1074/jbc.M111.265348  1
2011 Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutrition Research (New York, N.Y.). 31: 563-71. PMID 21840473 DOI: 10.1016/j.nutres.2011.06.004  1
2011 Ganu RS, Garrow TA, Sodhi M, Rund LA, Schook LB. Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes. Gene. 473: 133-8. PMID 21156199 DOI: 10.1016/j.gene.2010.11.015  1
2010 Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutrition Research (New York, N.Y.). 30: 492-500. PMID 20797482 DOI: 10.1016/j.nutres.2010.06.017  1
2009 Vanek V, Budesínský M, Kabeleová P, Sanda M, Kozísek M, Hanclová I, Mládková J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jirácek J. Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry. 52: 3652-65. PMID 19534555 DOI: 10.1021/jm8015798  1
2008 Williams KT, Garrow TA, Schalinske KL. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. The Journal of Nutrition. 138: 2064-9. PMID 18936199 DOI: 10.3945/jn.108.094144  1
2008 Castro C, Millian NS, Garrow TA. Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Archives of Biochemistry and Biophysics. 472: 26-33. PMID 18262489 DOI: 10.1016/j.abb.2008.01.017  1
2008 Szegedi SS, Castro CC, Koutmos M, Garrow TA. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. The Journal of Biological Chemistry. 283: 8939-45. PMID 18230605 DOI: 10.1074/jbc.M710449200  1
2007 Dilger RN, Garrow TA, Baker DH. Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. The Journal of Nutrition. 137: 2224-8. PMID 17885002  1
2007 Schäfer C, Hoffmann L, Heldt K, Lornejad-Schäfer MR, Brauers G, Gehrmann T, Garrow TA, Häussinger D, Mayatepek E, Schwahn BC, Schliess F. Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1089-98. PMID 17218476 DOI: 10.1152/ajpgi.00088.2006  1
2006 Slow S, Garrow TA. Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. The Journal of Nutrition. 136: 2279-83. PMID 16920841  1
2006 Nieman KM, Hartz CS, Szegedi SS, Garrow TA, Sparks JD, Schalinske KL. Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. American Journal of Physiology. Endocrinology and Metabolism. 291: E1235-42. PMID 16835399 DOI: 10.1152/ajpendo.00237.2006  1
2006 Jiracek J, Collinsova M, Rosenberg I, Budesinsky M, Protivinska E, Netusilova H, Garrow TA. S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. Journal of Medicinal Chemistry. 49: 3982-9. PMID 16789755 DOI: 10.1021/jm050885v  1
2006 Collinsova M, Strakova J, Jiracek J, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. The Journal of Nutrition. 136: 1493-7. PMID 16702310  1
2006 Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. American Journal of Physiology. Endocrinology and Metabolism. 290: E933-9. PMID 16352668 DOI: 10.1152/ajpendo.00498.2005  1
2005 Miller CM, Szegedi SS, Garrow TA. Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. The Biochemical Journal. 392: 443-8. PMID 16038618 DOI: 10.1042/BJ20050356  1
2005 Augspurger NR, Scherer CS, Garrow TA, Baker DH. Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. The Journal of Nutrition. 135: 1712-7. PMID 15987854  1
2005 Delgado-Reyes CV, Garrow TA. High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R182-7. PMID 15331385 DOI: 10.1152/ajpregu.00406.2004  1
2004 Tanghe KA, Garrow TA, Schalinske KL. Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats. The Journal of Nutrition. 134: 2913-8. PMID 15514252  1
2004 Nieman KM, Rowling MJ, Garrow TA, Schalinske KL. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. The Journal of Biological Chemistry. 279: 45708-12. PMID 15347642 DOI: 10.1074/jbc.M408664200  1
2004 Schwahn BC, Wendel U, Lussier-Cacan S, Mar MH, Zeisel SH, Leclerc D, Castro C, Garrow TA, Rozen R. Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism: Clinical and Experimental. 53: 594-9. PMID 15131763 DOI: 10.1016/j.metabol.2003.10.033  1
2004 Szegedi SS, Garrow TA. Oligomerization is required for betaine-homocysteine S-methyltransferase function. Archives of Biochemistry and Biophysics. 426: 32-42. PMID 15130780 DOI: 10.1016/j.abb.2004.03.040  1
2004 Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, Garrow TA. Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry. 43: 5341-51. PMID 15122900 DOI: 10.1021/bi049821x  1
2003 Weisberg IS, Park E, Ballman KV, Berger P, Nunn M, Suh DS, Breksa AP, Garrow TA, Rozen R. Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis. 167: 205-14. PMID 12818402 DOI: 10.1016/S0021-9150(03)00010-8  1
2003 Morin I, Platt R, Weisberg I, Sabbaghian N, Wu Q, Garrow TA, Rozen R. Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. American Journal of Medical Genetics. Part A. 119: 172-6. PMID 12749058 DOI: 10.1002/ajmg.a.20115  1
2003 Collinsová M, Castro C, Garrow TA, Yiotakis A, Dive V, Jirácek J. Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase. Chemistry & Biology. 10: 113-22. PMID 12618183 DOI: 10.1016/S1074-5521(03)00008-5  1
2003 Schwahn BC, Chen Z, Laryea MD, Wendel U, Lussier-Cacan S, Genest J, Mar MH, Zeisel SH, Castro C, Garrow T, Rozen R. Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 512-4. PMID 12551843 DOI: 10.1096/fj.02-0456fje  1
2002 Evans JC, Huddler DP, Jiracek J, Castro C, Millian NS, Garrow TA, Ludwig ML. Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (London, England : 1993). 10: 1159-71. PMID 12220488 DOI: 10.1016/S0969-2126(02)00796-7  1
2002 Halsted CH, Villanueva JA, Devlin AM, Niemelä O, Parkkila S, Garrow TA, Wallock LM, Shigenaga MK, Melnyk S, James SJ. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig Proceedings of the National Academy of Sciences of the United States of America. 99: 10072-10077. PMID 12122204 DOI: 10.1073/pnas.112336399  1
2002 Koval D, Kasicka V, Jirácek J, Collinsová M, Garrow TA. Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 770: 145-54. PMID 12013221 DOI: 10.1016/S1570-0232(01)00595-5  1
2002 Breksa AP, Garrow TA. Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Archives of Biochemistry and Biophysics. 399: 73-80. PMID 11883905 DOI: 10.1006/abbi.2001.2751  1
2001 Delgado-Reyes CV, Wallig MA, Garrow TA. Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney. Archives of Biochemistry and Biophysics. 393: 184-6. PMID 11516176 DOI: 10.1006/abbi.2001.2474  1
2000 Sandu C, Nick P, Hess D, Schiltz E, Garrow TA, Brandsch R. Association of betaine-homocysteine S-methyltransferase with microtubules Biological Chemistry. 381: 619-622. PMID 10987370  1
2000 Neece DJ, Griffiths MA, Garrow TA. Isolation and characterization of a mouse betaine-homocysteine S- methyltransferase gene and pseudogene Gene. 250: 31-40. PMID 10854776 DOI: 10.1016/S0378-1119(00)00191-8  1
1999 Breksa AP, Garrow TA. Recombinant human liver betaine-homocysteine S-methyltransferase: Identification of three cysteine residues critical for zinc binding Biochemistry. 38: 13991-13998. PMID 10529246 DOI: 10.1021/bi991003v  1
1999 Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, Green R, Kruger WD, Garrow TA, Jacobsen DW. Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease. Advances in Enzyme Regulation. 39: 93-109. PMID 10470368 DOI: 10.1016/S0065-2571(98)00029-6  1
1999 Sowden MP, Collins HL, Smith HC, Garrow TA, Sparks JD, Sparks CE. Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase. The Biochemical Journal. 341: 639-45. PMID 10417327 DOI: 10.1042/0264-6021:3410639  1
1999 Park EI, Garrow TA. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene Journal of Biological Chemistry. 274: 7816-7824. PMID 10075673 DOI: 10.1074/jbc.274.12.7816  1
1998 Rao PV, Garrow TA, John F, Garland D, Millian NS, Zigler JS. Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens. The Journal of Biological Chemistry. 273: 30669-74. PMID 9804840 DOI: 10.1074/jbc.273.46.30669  1
1998 Millian NS, Garrow TA. Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Archives of Biochemistry and Biophysics. 356: 93-8. PMID 9681996 DOI: 10.1006/abbi.1998.0757  1
1998 Emmert JL, Webel DM, Biehl RR, Griffiths MA, Garrow LS, Garrow TA, Baker DH. Hepatic and renal betaine-homocysteine methyltransferase activity in pigs as affected by dietary intakes of sulfur amino acids, choline, and betaine. Journal of Animal Science. 76: 606-10. PMID 9498371  1
1998 Mulligan JD, Laurie TJ, Garrow TA. An assay for betaine-homocysteine methyltransferase activity based on the microbiological detection of methionine Journal of Nutritional Biochemistry. 9: 351-354. DOI: 10.1016/S0955-2863(98)00025-4  1
1998 Park EI, Garrow LS, Mulligan JD, Millan NS, Renduchintala MS, Griffiths MA, Garrow TA. The interaction of methionine (Met) deficiency and dietary methyl donors on hepatic betaine-homocysteine methyltransferase (BHMT) gene expression Faseb Journal. 12.  1
1997 Sunden SLF, Renduchintala MS, Park EI, Miklasz SD, Garrow TA. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene Archives of Biochemistry and Biophysics. 345: 171-174. PMID 9281325 DOI: 10.1006/abbi.1997.0246  1
1997 Atkinson I, Garrow T, Brenner A, Shane B. Human cytosolic folylpoly-γ-glutamate synthase Methods in Enzymology. 281: 134-140. PMID 9250977 DOI: 10.1016/S0076-6879(97)81019-1  1
1997 Park EI, Renduchintala MS, Garrow TA. Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in the steady-state level of its mRNA Journal of Nutritional Biochemistry. 8: 541-545. DOI: 10.1016/S0955-2863(97)00101-0  1
1997 Zigler JS, Garrow TA, John F, Rao PV. High concentration of be' aine-homocysteine methyltransferase in rhesus monkey lens Investigative Ophthalmology and Visual Science. 38.  1
1996 Emmert JL, Garrow TA, Baker DH. Development of an experimental diet for determining bioavailable choline concentration and its application in studies with soybean lecithin. Journal of Animal Science. 74: 2738-44. PMID 8923188  1
1996 Lin BF, Kim JS, Hsu JC, Osborne C, Lowe K, Garrow T, Shane B. Chapter 5 Molecular Biology In Nutrition Research: Modeling Of Folate Metabolism Advances in Food and Nutrition Research. 40: 95-106. PMID 8858808 DOI: 10.1016/S1043-4526(08)60022-4  1
1996 Garrow TA. Purification, kinetic properties, and cDNA cloning of mammalian betaine- homocysteine methyltransferase Journal of Biological Chemistry. 271: 22831-22838. PMID 8798461  1
1996 Emmert JL, Garrow TA, Baker DH. Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine. The Journal of Nutrition. 126: 2050-8. PMID 8759379  1
1996 Chen L, Qi H, Korenberg J, Garrow TA, Choi YJ, Shane B. Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene. The Journal of Biological Chemistry. 271: 13077-87. PMID 8662720 DOI: 10.1074/jbc.271.22.13077  1
1996 Laune TJ, Garrow TA. A microbiological assay for betaine-homocysteine methyltransferase (BHMT) using microtiter plates Faseb Journal. 10.  1
1995 Egan MG, Sirlin S, Rumberger BG, Garrow TA, Shane B, Sirotnak FM. Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells: Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation Journal of Biological Chemistry. 270: 5462-5468. PMID 7890662 DOI: 10.1074/jbc.270.10.5462  1
1993 Garrow TA, Brenner AA, Whitehead VM, Chen XN, Duncan RG, Korenberg JR, Shane B. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. The Journal of Biological Chemistry. 268: 11910-6. PMID 8505317  1
1993 Garrow TA, Shane B. Purification and general properties of human folylpolyglutamase synthetase Advances in Experimental Medicine and Biology. 338: 659-662. PMID 8304201  1
1992 Garrow TA, Admon A, Shane B. Expression cloning of a human cDNA encoding folylpoly(γ-glutamate) synthetase and determination of its primary structure Proceedings of the National Academy of Sciences of the United States of America. 89: 9151-9155. PMID 1409616  1
1991 Garrow TA, Clegg MS, Metzler G, Keen CL. Influence of hypertension and dietary copper on indexes of copper status in rats Hypertension. 17: 793-797. PMID 2045141  1
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