Warren D. Kruger, PhD - Publications

1995- Fox Chase Cancer Center 
Human Genetics and Disease

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, Anafi RC, Kavakli IH. CRY1-CBS binding regulates circadian clock function and metabolism. The Febs Journal. PMID 32383312 DOI: 10.1111/Febs.15360  0.336
2019 Gupta S, Gallego-Villar L, Wang L, Lee HO, Nasrallah G, Al-Dewik N, Häberle J, Thöny B, Blom HJ, Ben-Omran T, Kruger WD. Analysis of the Qatari R336C Cystathionine β-Synthase Protein in Mice. Journal of Inherited Metabolic Disease. PMID 31240737 DOI: 10.1002/Jimd.12140  0.412
2019 Lee HO, Gallego-Villar L, Grisch-Chan HM, Haeberle J, Thöny B, Kruger W. Treatment of CBS deficiency in mice using a minicircle-based naked DNA vector. Human Gene Therapy. PMID 31084364 DOI: 10.1089/Hum.2019.014  0.366
2018 Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Häberle J, Thöny B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK. In silico and in vivo models for Qatari-Specific classical homocystinuria as basis for development of novel therapies. Human Mutation. PMID 30408270 DOI: 10.1002/Humu.23682  0.338
2018 Gupta S, Kelow S, Wang L, Andrake M, Dunbrack RL, Kruger WD. Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine β-synthase () reveal effects on CBS activity but not stability. The Journal of Biological Chemistry. PMID 30030379 DOI: 10.1074/Jbc.Ra118.002164  0.409
2018 Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD. S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice. Molecular Genetics and Metabolism Reports. 15: 15-21. PMID 30023284 DOI: 10.1016/J.Ymgmr.2018.01.002  0.381
2018 Tang B, Lee HO, An SS, Cai KQ, Kruger WD. Specific targeting of MTAP-deleted tumors with a combination of 2'-fluoroadenine and 5'-methylthioadenosine. Cancer Research. PMID 29844120 DOI: 10.1158/0008-5472.Can-18-0814  0.327
2017 Majtan T, Jones W, Krijt J, Park I, Kruger WD, Kožich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29398487 DOI: 10.1016/J.Ymthe.2017.12.014  0.347
2017 Gallego-Villar L, Hannibal L, Häberle J, Thöny B, Ben-Omran T, Nasrallah GK, Dewik AN, Kruger WD, Blom HJ. Cysteamine revisited: repair of arginine to cysteine mutations. Journal of Inherited Metabolic Disease. PMID 28643139 DOI: 10.1007/S10545-017-0060-4  0.357
2017 Kruger WD. Cystathionine β-synthase deficiency: Of mice and men. Molecular Genetics and Metabolism. PMID 28583326 DOI: 10.1016/J.Ymgme.2017.05.011  0.367
2017 Gupta S, Wang L, Kruger WD. The c.797 G>A (p.R266K) cystathionine β-Synthase mutation causes Homocystinuria by affecting protein stability. Human Mutation. PMID 28488385 DOI: 10.1002/Humu.23240  0.441
2017 Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 598-609. PMID 28148781 DOI: 10.1096/Fj.201600915R  0.341
2016 Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Praticò D. Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. Aging Cell. PMID 27896923 DOI: 10.1111/Acel.12550  0.348
2016 Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. Journal of Inherited Metabolic Disease. PMID 27444757 DOI: 10.1007/S10545-016-9958-5  0.349
2015 Kruger WD, Gupta S. The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Annals of the New York Academy of Sciences. PMID 26599618 DOI: 10.1111/Nyas.12967  0.39
2015 Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. Journal of Inherited Metabolic Disease. PMID 26231230 DOI: 10.1007/S10545-015-9883-Z  0.345
2015 Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, de Vriese AS, de Baulny HO, Kruger W, Schiff M, Blom HJ. High homocysteine induces betaine depletion. Bioscience Reports. 35. PMID 26182429 DOI: 10.1042/Bsr20150094  0.322
2015 Gupta S, Kruger WD. Abstract 4785: Deficiency of cystathionine beta synthase gene does not affect tumor formation and survival of Eμ-myc mice Cancer Research. 75: 4785-4785. DOI: 10.1158/1538-7445.Am2015-4785  0.329
2014 Tang B, Kadariya Y, Chen Y, Slifker M, Kruger WD. Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3 (Bethesda, Md.). 5: 35-44. PMID 25387827 DOI: 10.1534/G3.114.014555  0.341
2014 Fang P, Zhang D, Cheng Z, Yan C, Jiang X, Kruger WD, Meng S, Arning E, Bottiglieri T, Choi ET, Han Y, Yang XF, Wang H. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes. 63: 4275-90. PMID 25008174 DOI: 10.2337/Db14-0809  0.33
2014 Esse R, Imbard A, Florindo C, Gupta S, Quinlivan EP, Davids M, Teerlink T, Tavares de Almeida I, Kruger WD, Blom HJ, Castro R. Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2686-95. PMID 24532665 DOI: 10.1096/Fj.13-246579  0.354
2014 Gupta S, Melnyk SB, Kruger WD. Cystathionine β-synthase-deficient mice thrive on a low-methionine diet. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 781-90. PMID 24189943 DOI: 10.1096/Fj.13-240770  0.319
2013 Kadariya Y, Tang B, Wang L, Al-Saleem T, Hayakawa K, Slifker MJ, Kruger WD. Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. Plos One. 8: e67635. PMID 23840755 DOI: 10.1371/Journal.Pone.0067635  0.408
2013 Gupta S, Wang L, Anderl J, Slifker MJ, Kirk C, Kruger WD. Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitors. Human Mutation. 34: 1085-93. PMID 23592311 DOI: 10.1002/Humu.22335  0.436
2012 Zitserman D, Gupta S, Kruger WD, Karbowniczek M, Roegiers F. The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis. Plos One. 7: e48720. PMID 23144943 DOI: 10.1371/Journal.Pone.0048720  0.36
2012 Tang B, Testa JR, Kruger WD. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biology & Therapy. 13: 1082-90. PMID 22825330 DOI: 10.4161/Cbt.21115  0.324
2012 Régnier V, Billard JM, Gupta S, Potier B, Woerner S, Paly E, Ledru A, David S, Luilier S, Bizot JC, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, et al. Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. Plos One. 7: e29056. PMID 22253703 DOI: 10.1371/Journal.Pone.0029056  0.356
2012 Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood. 119: 3176-83. PMID 22186991 DOI: 10.1182/Blood-2011-09-380568  0.306
2012 Kruger WD, Kadariya Y, Tang B, Al-Saleem T, Haykawa K. Abstract 2173: Heterozygosity for Mtap accelerates lymphomagenesis in Emu-Myc and Pten +/− mice Cancer Research. 72: 2173-2173. DOI: 10.1158/1538-7445.Am2012-2173  0.373
2011 Gupta S, Kruger WD. Cystathionine beta-synthase deficiency causes fat loss in mice. Plos One. 6: e27598. PMID 22096601 DOI: 10.1371/Journal.Pone.0027598  0.339
2011 Cheng Z, Jiang X, Kruger WD, Praticò D, Gupta S, Mallilankaraman K, Madesh M, Schafer AI, Durante W, Yang X, Wang H. Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood. 118: 1998-2006. PMID 21653942 DOI: 10.1182/Blood-2011-01-333310  0.304
2011 Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair. The Journal of Nutritional Biochemistry. 22: 1022-9. PMID 21193302 DOI: 10.1016/J.Jnutbio.2010.07.015  0.35
2010 Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutrition Research (New York, N.Y.). 30: 492-500. PMID 20797482 DOI: 10.1016/J.Nutres.2010.06.017  0.333
2010 Wei Q, Wang L, Wang Q, Kruger WD, Dunbrack RL. Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins. 78: 2058-74. PMID 20455263 DOI: 10.1002/Prot.22722  0.361
2010 Zhuo JM, Kruger WD, Praticò D. The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. Journal of Alzheimer's Disease : Jad. 20: 569-76. PMID 20164556 DOI: 10.3233/Jad-2010-1394  0.353
2010 Singh LR, Gupta S, Honig NH, Kraus JP, Kruger WD. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. Plos Genetics. 6: e1000807. PMID 20066033 DOI: 10.1371/Journal.Pgen.1000807  0.393
2010 Tang B, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase. Nutrition (Burbank, Los Angeles County, Calif.). 26: 1170-5. PMID 20036517 DOI: 10.1016/J.Nut.2009.10.006  0.399
2009 Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Research. 69: 5961-9. PMID 19567676 DOI: 10.1158/0008-5472.Can-09-0145  0.402
2009 Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1721-7. PMID 19204075 DOI: 10.1096/Fj.08-127548  0.329
2009 Singh LR, Kruger WD. Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 284: 4238-45. PMID 19074437 DOI: 10.1074/Jbc.M806387200  0.336
2009 Gupta S, Kühnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 883-93. PMID 18987302 DOI: 10.1096/Fj.08-120584  0.367
2008 Majtan T, Singh LR, Wang L, Kruger WD, Kraus JP. Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. The Journal of Biological Chemistry. 283: 34588-95. PMID 18849566 DOI: 10.1074/Jbc.M805928200  0.333
2008 Roy M, Leclerc D, Wu Q, Gupta S, Kruger WD, Rozen R. Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Journal of Cellular Biochemistry. 105: 467-76. PMID 18615588 DOI: 10.1002/Jcb.21847  0.37
2008 Gupta S, Wang L, Hua X, Krijt J, Kozich V, Kruger WD. Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Human Mutation. 29: 1048-54. PMID 18454451 DOI: 10.1002/Humu.20773  0.419
2007 van Slegtenhorst M, Khabibullin D, Hartman TR, Nicolas E, Kruger WD, Henske EP. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 282: 24583-90. PMID 17556368 DOI: 10.1074/Jbc.M700857200  0.393
2007 Singh LR, Chen X, Kozich V, Kruger WD. Chemical chaperone rescue of mutant human cystathionine beta-synthase. Molecular Genetics and Metabolism. 91: 335-42. PMID 17540596 DOI: 10.1016/J.Ymgme.2007.04.011  0.402
2006 Chen X, Wang L, Fazlieva R, Kruger WD. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Human Mutation. 27: 474-82. PMID 16619244 DOI: 10.1002/Humu.20320  0.361
2005 Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Human Molecular Genetics. 14: 2201-8. PMID 15972722 DOI: 10.1093/Hmg/Ddi224  0.409
2005 Jhee KH, Kruger WD. The role of cystathionine beta-synthase in homocysteine metabolism. Antioxidants & Redox Signaling. 7: 813-22. PMID 15890029 DOI: 10.1089/Ars.2005.7.813  0.332
2005 Kadariya Y, Nakatani K, Nishioka J, Fujikawa T, Kruger WD, Nobori T. Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y). The Biochemical Journal. 387: 175-83. PMID 15535799 DOI: 10.1042/Bj20041472  0.351
2004 Subhi AL, Tang B, Balsara BR, Altomare DA, Testa JR, Cooper HS, Hoffman JP, Meropol NJ, Kruger WD. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7290-6. PMID 15534104 DOI: 10.1158/1078-0432.Ccr-04-0972  0.321
2004 Wang L, Jhee KH, Hua X, DiBello PM, Jacobsen DW, Kruger WD. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circulation Research. 94: 1318-24. PMID 15105297 DOI: 10.1161/01.Res.0000129182.46440.4A  0.367
2004 van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 279: 12706-13. PMID 14718525 DOI: 10.1074/Jbc.M313874200  0.417
2004 Oh H, Park E, Kruger W, Jung S, Lee J. 181. Human CBS (Cystathionine |[beta]|-Synthase) Gene Transfer Mediated by Recombinant Adeno-Associated Virus Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.141  0.416
2003 Kruger WD, Wang L, Jhee KH, Singh RH, Elsas LJ. Cystathionine beta-synthase deficiency in Georgia (USA): correlation of clinical and biochemical phenotype with genotype. Human Mutation. 22: 434-41. PMID 14635102 DOI: 10.1002/Humu.10290  0.364
2003 Subhi AL, Diegelman P, Porter CW, Tang B, Lu ZJ, Markham GD, Kruger WD. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. The Journal of Biological Chemistry. 278: 49868-73. PMID 14506228 DOI: 10.1074/Jbc.M308451200  0.407
2002 Christopher SA, Melnyk S, James SJ, Kruger WD. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Molecular Genetics and Metabolism. 75: 335-43. PMID 12051965 DOI: 10.1016/S1096-7192(02)00003-3  0.356
2001 Shan X, Dunbrack RL, Christopher SA, Kruger WD. Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis. Human Molecular Genetics. 10: 635-43. PMID 11230183 DOI: 10.1093/Hmg/10.6.635  0.381
2001 Strizheva GD, Carsillo T, Kruger WD, Sullivan EJ, Ryu JH, Henske EP. The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. American Journal of Respiratory and Critical Care Medicine. 163: 253-8. PMID 11208653 DOI: 10.1164/Ajrccm.163.1.2005004  0.325
2000 Kruger WD, Evans AA, Wang L, Malinow MR, Duell PB, Anderson PH, Block PC, Hess DL, Graf EE, Upson B. Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Molecular Genetics and Metabolism. 70: 53-60. PMID 10833331 DOI: 10.1006/Mgme.2000.2993  0.313
1999 Shan X, Wang L, Hoffmaster R, Kruger WD. Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 274: 32613-8. PMID 10551815 DOI: 10.1074/Jbc.274.46.32613  0.42
1999 Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, Green R, Kruger WD, Garrow TA, Jacobsen DW. Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease. Advances in Enzyme Regulation. 39: 93-109. PMID 10470368 DOI: 10.1016/S0065-2571(98)00029-6  0.311
1999 Kraus JP, Janosík M, Kozich V, Mandell R, Shih V, Sperandeo MP, Sebastio G, de Franchis R, Andria G, Kluijtmans LA, Blom H, Boers GH, Gordon RB, Kamoun P, Tsai MY, ... Kruger WD, et al. Cystathionine beta-synthase mutations in homocystinuria. Human Mutation. 13: 362-75. PMID 10338090 DOI: 10.1002/(Sici)1098-1004(1999)13:5<362::Aid-Humu4>3.0.Co;2-K  0.375
1998 Taoka S, Ohja S, Shan X, Kruger WD, Banerjee R. Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity. The Journal of Biological Chemistry. 273: 25179-84. PMID 9737978 DOI: 10.1074/Jbc.273.39.25179  0.309
1998 Shan X, Kruger WD. Correction of disease-causing CBS mutations in yeast. Nature Genetics. 19: 91-3. PMID 9590298 DOI: 10.1038/Ng0598-91  0.408
1997 Kim CE, Gallagher PM, Guttormsen AB, Refsum H, Ueland PM, Ose L, Folling I, Whitehead AS, Tsai MY, Kruger WD. Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria. Human Molecular Genetics. 6: 2213-21. PMID 9361025 DOI: 10.1093/Hmg/6.13.2213  0.377
1996 Gulati S, Baker P, Li YN, Fowler B, Kruger W, Brody LC, Banerjee R. Defects in human methionine synthase in cblG patients. Human Molecular Genetics. 5: 1859-65. PMID 8968736 DOI: 10.1093/Hmg/5.12.1859  0.403
1996 Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. Cloning, mapping and RNA analysis of the human methionine synthase gene. Human Molecular Genetics. 5: 1851-8. PMID 8968735 DOI: 10.1093/Hmg/5.12.1851  0.344
1995 Kruger W, Peterson CL, Sil A, Coburn C, Arents G, Moudrianakis EN, Herskowitz I. Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Genes & Development. 9: 2770-9. PMID 7590252 DOI: 10.1101/Gad.9.22.2770  0.692
1992 Herskowitz I, Andrews B, Kruger W, Ogas J, Sil A, Coburn C, Peterson C. 36 Integration of Multiple Regulatory Inputs in the Control of HO Expression in Yeast Cold Spring Harbor Monograph Archive. 949-974. DOI: 10.1101/087969425.22B.949  0.706
1991 Kruger W, Herskowitz I. A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1. Molecular and Cellular Biology. 11: 4135-46. PMID 2072912 DOI: 10.1128/Mcb.11.8.4135  0.61
1991 Peterson CL, Kruger W, Herskowitz I. A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1. Cell. 64: 1135-43. PMID 2004420 DOI: 10.1016/0092-8674(91)90268-4  0.641
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