Daniel G. Isom, Ph.D. - Publications

Affiliations: 
2006 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics

21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kapolka NJ, Rowe JB, Taghon GJ, Morgan WM, O'Shea CR, Isom DG. Proton-gated coincidence detection is a common feature of GPCR signaling. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34260394 DOI: 10.1073/pnas.2100171118  0.6
2021 Taghon GJ, Rowe JB, Kapolka NJ, Isom DG. Predictable cholesterol binding sites in GPCRs lack consensus motifs. Structure (London, England : 1993). PMID 33508215 DOI: 10.1016/j.str.2021.01.004  0.6
2020 Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry. 296: 100167. PMID 33478938 DOI: 10.1074/jbc.RA120.016352  0.6
2020 Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. The evolution and mechanism of GPCR proton sensing. The Journal of Biological Chemistry. PMID 33298521 DOI: 10.1074/jbc.RA120.016352  0.6
2020 Kapolka NJ, Isom DG. HCAR3: an underexplored metabolite sensor. Nature Reviews. Drug Discovery. PMID 33009526 DOI: 10.1038/d41573-020-00173-2  0.6
2020 Kapolka NJ, Taghon GJ, Rowe JB, Morgan WM, Enten JF, Lambert NA, Isom DG. DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery. Proceedings of the National Academy of Sciences of the United States of America. PMID 32434907 DOI: 10.1073/Pnas.2000430117  0.6
2020 Rowe JB, Taghon GJ, Kapolka NJ, Morgan WM, Isom DG. CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology. The Journal of Biological Chemistry. PMID 32358068 DOI: 10.1074/Jbc.Ra120.013066  0.6
2017 Isom DG, Page SC, Collins LB, Kapolka NJ, Taghon GJ, Dohlman HG. Coordinated Regulation of Intracellular pH by Two Glucose Sensing Pathways in Yeast. The Journal of Biological Chemistry. PMID 29284676 DOI: 10.1074/Jbc.Ra117.000422  0.68
2017 Shellhammer JP, Morin-Kensicki E, Matson JP, Yin G, Isom DG, Campbell SL, Mohney RP, Dohlman HG. Amino acid metabolites that regulate G protein signaling during osmotic stress. Plos Genetics. 13: e1006829. PMID 28558063 DOI: 10.1371/Journal.Pgen.1006829  0.68
2016 Isom DG, Sridharan V, Dohlman HG. Regulation of Ras Paralog Thermostability by Networks of Buried Ionizable Groups. Biochemistry. 55: 534-42. PMID 26701741 DOI: 10.1021/Acs.Biochem.5B00901  0.84
2015 Isom DG, Dohlman HG. Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 112: 5702-7. PMID 25902551 DOI: 10.1073/Pnas.1417888112  0.84
2013 Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL. Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. The Journal of Biological Chemistry. 288: 36856-62. PMID 24247240 DOI: 10.1074/Jbc.C113.525691  0.84
2013 Isom DG, Sridharan V, Baker R, Clement ST, Smalley DM, Dohlman HG. Protons as second messenger regulators of G protein signaling. Molecular Cell. 51: 531-8. PMID 23954348 DOI: 10.1016/J.Molcel.2013.07.012  0.68
2011 Isom DG, Castañeda CA, Cannon BR, García-Moreno B. Large shifts in pKa values of lysine residues buried inside a protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 5260-5. PMID 21389271 DOI: 10.1073/Pnas.1010750108  0.84
2011 Isom DG, Marguet PR, Oas TG, Hellinga HW. A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. Proteins. 79: 1034-47. PMID 21387407 DOI: 10.1002/Prot.22932  0.84
2010 Isom DG, Castañeda CA, Cannon BR, Velu PD, García-Moreno E B. Charges in the hydrophobic interior of proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 16096-100. PMID 20798341 DOI: 10.1073/Pnas.1004213107  0.84
2010 Isom DG, Vardy E, Oas TG, Hellinga HW. Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 4908-13. PMID 20194783 DOI: 10.1073/Pnas.0910421107  0.84
2009 Harms MJ, Castañeda CA, Schlessman JL, Sue GR, Isom DG, Cannon BR, García-Moreno E B. The pK(a) values of acidic and basic residues buried at the same internal location in a protein are governed by different factors. Journal of Molecular Biology. 389: 34-47. PMID 19324049 DOI: 10.1016/J.Jmb.2009.03.039  0.84
2008 Isom DG, Cannon BR, Castañeda CA, Robinson A, García-Moreno B. High tolerance for ionizable residues in the hydrophobic interior of proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 17784-8. PMID 19004768 DOI: 10.1073/Pnas.0805113105  0.84
2006 Brun L, Isom DG, Velu P, García-Moreno B, Royer CA. Hydration of the folding transition state ensemble of a protein. Biochemistry. 45: 3473-80. PMID 16533028 DOI: 10.1021/Bi052638Z  0.84
2003 Gong H, Isom DG, Srinivasan R, Rose GD. Local secondary structure content predicts folding rates for simple, two-state proteins. Journal of Molecular Biology. 327: 1149-54. PMID 12662937 DOI: 10.1016/S0022-2836(03)00211-0  0.84
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