Fred Homa - Publications

Affiliations: 
Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Virology Biology, Molecular Biology, Microbiology Biology

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bayer AN, Homa FL. Exposing the invader. Elife. 11. PMID 35635544 DOI: 10.7554/eLife.79813  0.426
2021 Freeman KG, Huffman JB, Homa FL, Evilevitch A. UL25 capsid binding facilitates mechanical maturation of the Herpesvirus capsid and allows retention of pressurized DNA. Journal of Virology. JVI0075521. PMID 34346766 DOI: 10.1128/JVI.00755-21  0.565
2020 Huet A, Huffman JB, Conway JF, Homa FL. The role of the herpes simplex virus CVSC proteins at the capsid portal vertex. Journal of Virology. PMID 32967953 DOI: 10.1128/JVI.01534-20  0.677
2017 Heming JD, Conway JF, Homa FL. Herpesvirus Capsid Assembly and DNA Packaging. Advances in Anatomy, Embryology, and Cell Biology. 223: 119-142. PMID 28528442 DOI: 10.1007/978-3-319-53168-7_6  0.679
2017 Huffman JB, Daniel GR, Falck-Pedersen E, Huet A, Smith GA, Conway JF, Homa FL. The C-terminus of the herpes simplex virus pUL25 protein is required for release of viral genomes from capsids bound to nuclear pores. Journal of Virology. PMID 28490590 DOI: 10.1128/Jvi.00641-17  0.615
2016 Huet A, Makhov AM, Huffman JB, Vos M, Homa FL, Conway JF. Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery. Nature Structural & Molecular Biology. PMID 27111889 DOI: 10.1038/nsmb.3212  0.566
2015 Bauer DW, Li D, Huffman J, Homa FL, Wilson K, Leavitt JC, Casjens SR, Baines J, Evilevitch A. Exploring the balance between DNA pressure and capsid stability in Herpes and phage. Journal of Virology. PMID 26136570 DOI: 10.1128/Jvi.01172-15  0.504
2015 Sae-Ueng U, Li D, Zuo X, Huffman JB, Homa FL, Rau D, Evilevitch A. Erratum: Corrigendum: Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection Nature Chemical Biology. 11: 172-172. DOI: 10.1038/nchembio0215-172d  0.317
2014 Sae-Ueng U, Li D, Zuo X, Huffman JB, Homa FL, Rau D, Evilevitch A. Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection. Nature Chemical Biology. 10: 861-7. PMID 25195012 DOI: 10.1016/J.Bpj.2014.11.1924  0.572
2014 Sae-Ueng U, Liu T, Catalano CE, Huffman JB, Homa FL, Evilevitch A. Major capsid reinforcement by a minor protein in herpesviruses and phage. Nucleic Acids Research. 42: 9096-107. PMID 25053840 DOI: 10.1093/Nar/Gku634  0.574
2014 Heming JD, Huffman JB, Jones LM, Homa FL. Isolation and characterization of the herpes simplex virus 1 terminase complex. Journal of Virology. 88: 225-36. PMID 24155374 DOI: 10.1128/Jvi.02632-13  0.664
2013 Bauer DW, Huffman JB, Homa FL, Evilevitch A. Herpes virus genome, the pressure is on. Journal of the American Chemical Society. 135: 11216-21. PMID 23829592 DOI: 10.1021/ja404008r  0.514
2013 Homa FL, Huffman JB, Toropova K, Lopez HR, Makhov AM, Conway JF. Structure of the pseudorabies virus capsid: comparison with herpes simplex virus type 1 and differential binding of essential minor proteins. Journal of Molecular Biology. 425: 3415-28. PMID 23827137 DOI: 10.1016/J.Jmb.2013.06.034  0.612
2011 Toropova K, Huffman JB, Homa FL, Conway JF. The herpes simplex virus 1 UL17 protein is the second constituent of the capsid vertex-specific component required for DNA packaging and retention. Journal of Virology. 85: 7513-22. PMID 21632758 DOI: 10.1128/JVI.00837-11  0.556
2011 Cockrell SK, Huffman JB, Toropova K, Conway JF, Homa FL. Residues of the UL25 protein of herpes simplex virus that are required for its stable interaction with capsids. Journal of Virology. 85: 4875-87. PMID 21411517 DOI: 10.1128/Jvi.00242-11  0.79
2010 Conway JF, Cockrell SK, Copeland AM, Newcomb WW, Brown JC, Homa FL. Labeling and localization of the herpes simplex virus capsid protein UL25 and its interaction with the two triplexes closest to the penton. Journal of Molecular Biology. 397: 575-86. PMID 20109467 DOI: 10.1016/J.Jmb.2010.01.043  0.802
2009 Newcomb WW, Cockrell SK, Homa FL, Brown JC. Polarized DNA ejection from the herpesvirus capsid. Journal of Molecular Biology. 392: 885-94. PMID 19631662 DOI: 10.1016/J.Jmb.2009.07.052  0.765
2009 Cockrell SK, Sanchez ME, Erazo A, Homa FL. Role of the UL25 protein in herpes simplex virus DNA encapsidation. Journal of Virology. 83: 47-57. PMID 18945788 DOI: 10.1128/Jvi.01889-08  0.816
2008 Huffman JB, Newcomb WW, Brown JC, Homa FL. Amino acids 143 to 150 of the herpes simplex virus type 1 scaffold protein are required for the formation of portal-containing capsids. Journal of Virology. 82: 6778-81. PMID 18417585 DOI: 10.1128/JVI.00473-08  0.563
2007 Trus BL, Newcomb WW, Cheng N, Cardone G, Marekov L, Homa FL, Brown JC, Steven AC. Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids. Molecular Cell. 26: 479-89. PMID 17531807 DOI: 10.1016/J.Molcel.2007.04.010  0.481
2007 Yang K, Homa F, Baines JD. Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus. Journal of Virology. 81: 6419-33. PMID 17392365 DOI: 10.1128/Jvi.00047-07  0.662
2006 Jacobson JG, Yang K, Baines JD, Homa FL. Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation. Journal of Virology. 80: 12312-23. PMID 17035316 DOI: 10.1128/Jvi.01766-06  0.621
2006 Newcomb WW, Homa FL, Brown JC. Herpes simplex virus capsid structure: DNA packaging protein UL25 is located on the external surface of the capsid near the vertices. Journal of Virology. 80: 6286-94. PMID 16775316 DOI: 10.1128/JVI.02648-05  0.594
2006 Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP. Crystal structure of the herpes simplex virus 1 DNA polymerase. The Journal of Biological Chemistry. 281: 18193-200. PMID 16638752 DOI: 10.1074/jbc.M602414200  0.555
2005 Schnute ME, Cudahy MM, Brideau RJ, Homa FL, Hopkins TA, Knechtel ML, Oien NL, Pitts TW, Poorman RA, Wathen MW, Wieber JL. 4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases. Journal of Medicinal Chemistry. 48: 5794-804. PMID 16134946 DOI: 10.1021/jm050162b  0.352
2005 Newcomb WW, Homa FL, Brown JC. Involvement of the portal at an early step in herpes simplex virus capsid assembly. Journal of Virology. 79: 10540-6. PMID 16051846 DOI: 10.1128/JVI.79.16.10540-10546.2005  0.363
2005 Singer GP, Newcomb WW, Thomsen DR, Homa FL, Brown JC. Identification of a region in the herpes simplex virus scaffolding protein required for interaction with the portal. Journal of Virology. 79: 132-9. PMID 15596809 DOI: 10.1128/JVI.79.1.132-139.2005  0.586
2004 Trus BL, Cheng N, Newcomb WW, Homa FL, Brown JC, Steven AC. Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1. Journal of Virology. 78: 12668-71. PMID 15507654 DOI: 10.1128/Jvi.78.22.12668-12671.2004  0.363
2004 Douglas MW, Diefenbach RJ, Homa FL, Miranda-Saksena M, Rixon FJ, Vittone V, Byth K, Cunningham AL. Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. The Journal of Biological Chemistry. 279: 28522-30. PMID 15117959 DOI: 10.1074/jbc.M311671200  0.506
2003 Newcomb WW, Thomsen DR, Homa FL, Brown JC. Assembly of the herpes simplex virus capsid: identification of soluble scaffold-portal complexes and their role in formation of portal-containing capsids. Journal of Virology. 77: 9862-71. PMID 12941896  0.332
2003 Thomsen DR, Oien NL, Hopkins TA, Knechtel ML, Brideau RJ, Wathen MW, Homa FL. Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents. Journal of Virology. 77: 1868-76. PMID 12525621  0.467
2001 Newcomb WW, Juhas RM, Thomsen DR, Homa FL, Burch AD, Weller SK, Brown JC. The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. Journal of Virology. 75: 10923-32. PMID 11602732 DOI: 10.1128/Jvi.75.22.10923-10932.2001  0.545
2001 Newcomb WW, Homa FL, Thomsen DR, Brown JC. In vitro assembly of the herpes simplex virus procapsid: formation of small procapsids at reduced scaffolding protein concentration. Journal of Structural Biology. 133: 23-31. PMID 11356061 DOI: 10.1006/jsbi.2001.4329  0.45
1999 Newcomb WW, Homa FL, Thomsen DR, Trus BL, Cheng N, Steven A, Booy F, Brown JC. Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins. Journal of Virology. 73: 4239-50. PMID 10196320 DOI: 10.1128/Jvi.73.5.4239-4250.1999  0.528
1998 Spencer JV, Newcomb WW, Thomsen DR, Homa FL, Brown JC. Assembly of the herpes simplex virus capsid: preformed triplexes bind to the nascent capsid. Journal of Virology. 72: 3944-51. PMID 9557680 DOI: 10.1128/jvi.72.5.3944-3951.1998  0.583
1998 McNab AR, Desai P, Person S, Roof LL, Thomsen DR, Newcomb WW, Brown JC, Homa FL. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA. Journal of Virology. 72: 1060-70. PMID 9445000 DOI: 10.1128/jvi.72.2.1060-1070.1998  0.626
1997 Wingfield PT, Stahl SJ, Thomsen DR, Homa FL, Booy FP, Trus BL, Steven AC. Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus. Journal of Virology. 71: 8955-61. PMID 9371551 DOI: 10.1128/jvi.71.12.8955-8961.1997  0.5
1997 Oien NL, Thomsen DR, Wathen MW, Newcomb WW, Brown JC, Homa FL. Assembly of herpes simplex virus capsids using the human cytomegalovirus scaffold protein: critical role of the C terminus. Journal of Virology. 71: 1281-91. PMID 8995652 DOI: 10.1128/jvi.71.2.1281-1291.1997  0.491
1996 Trus BL, Booy FP, Newcomb WW, Brown JC, Homa FL, Thomsen DR, Steven AC. The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly. Journal of Molecular Biology. 263: 447-62. PMID 8918600 DOI: 10.1016/S0022-2836(96)80018-0  0.469
1996 Newcomb WW, Homa FL, Thomsen DR, Booy FP, Trus BL, Steven AC, Spencer JV, Brown JC. Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation. Journal of Molecular Biology. 263: 432-46. PMID 8918599 DOI: 10.1006/Jmbi.1996.0587  0.491
1995 Weiland KL, Oien NL, Homa F, Wathen MW. Functional analysis of human cytomegalovirus polymerase accessory protein. Virus Research. 34: 191-206. PMID 7856311 DOI: 10.1016/0168-1702(94)90124-4  0.546
1995 Thomsen DR, Newcomb WW, Brown JC, Homa FL. Assembly of the herpes simplex virus capsid: requirement for the carboxyl-terminal twenty-five amino acids of the proteins encoded by the UL26 and UL26.5 genes. Journal of Virology. 69: 3690-703. PMID 7745718 DOI: 10.1128/jvi.69.6.3690-3703.1995  0.528
1995 Haanes EJ, Thomsen DR, Martin S, Homa FL, Lowery DE. The bovine herpesvirus 1 maturational proteinase and scaffold proteins can substitute for the homologous herpes simplex virus type 1 proteins in the formation of hybrid type B capsids. Journal of Virology. 69: 7375-9. PMID 7474173 DOI: 10.1128/jvi.69.11.7375-7379.1995  0.55
1995 Trus BL, Homa FL, Booy FP, Newcomb WW, Thomsen DR, Cheng N, Brown JC, Steven AC. Herpes simplex virus capsids assembled in insect cells infected with recombinant baculoviruses: structural authenticity and localization of VP26. Journal of Virology. 69: 7362-6. PMID 7474170 DOI: 10.1128/jvi.69.11.7362-7366.1995  0.498
1994 Thomsen DR, Roof LL, Homa FL. Assembly of herpes simplex virus (HSV) intermediate capsids in insect cells infected with recombinant baculoviruses expressing HSV capsid proteins. Journal of Virology. 68: 2442-57. PMID 8139029 DOI: 10.1128/jvi.68.4.2442-2457.1994  0.49
1994 Desai P, Homa FL, Person S, Glorioso JC. A genetic selection method for the transfer of HSV-1 glycoprotein B mutations from plasmid to the viral genome: preliminary characterization of transdominance and entry kinetics of mutant viruses. Virology. 204: 312-22. PMID 8091662 DOI: 10.1006/Viro.1994.1536  0.461
1994 Newcomb WW, Homa FL, Thomsen DR, Ye Z, Brown JC. Cell-free assembly of the herpes simplex virus capsid. Journal of Virology. 68: 6059-63. PMID 8057482 DOI: 10.1128/jvi.68.9.6059-6063.1994  0.529
1993 Tengelsen LA, Pederson NE, Shaver PR, Wathen MW, Homa FL. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: isolation and characterization of two UL28 deletion mutants. Journal of Virology. 67: 3470-80. PMID 8388510 DOI: 10.1128/jvi.67.6.3470-3480.1993  0.549
1993 Lehman DJ, Roof LL, Brideau RJ, Aeed PA, Thomsen DR, Elhammer AP, Wathen MW, Homa FL. Comparison of soluble and secreted forms of human parainfluenza virus type 3 glycoproteins expressed from mammalian and insect cells as subunit vaccines. The Journal of General Virology. 459-69. PMID 8383178 DOI: 10.1099/0022-1317-74-3-459  0.372
1993 Cavalcoli JD, Baghian A, Homa FL, Kousoulas KG. Resolution of Genotypic and Phenotypic Properties of Herpes Simplex Virus Type 1 Temperature-Sensitive Mutant (KOS) tsZ47: Evidence for Allelic Complementation in the UL28 Gene Virology. 197: 23-34. PMID 8212558 DOI: 10.1006/Viro.1993.1563  0.535
1992 Pederson NE, Person S, Homa FL. Analysis of the gB promoter of herpes simplex virus type 1: high-level expression requires both an 89-base-pair promoter fragment and a nontranslated leader sequence. Journal of Virology. 66: 6226-32. PMID 1326669 DOI: 10.1128/jvi.66.10.6226-6232.1992  0.359
1990 Levine M, Krikos A, Glorioso JC, Homa FL. Regulation of expression of the glycoprotein genes of herpes simplex virus type 1 (HSV-1). Advances in Experimental Medicine and Biology. 278: 151-64. PMID 1963032 DOI: 10.1007/978-1-4684-5853-4_16  0.498
1990 Wu CT, Levine M, Homa F, Highlander SL, Glorioso JC. Characterization of the antigenic structure of herpes simplex virus type 1 glycoprotein C through DNA sequence analysis of monoclonal antibody-resistant mutants. Journal of Virology. 64: 856-63. PMID 1688628 DOI: 10.1128/Jvi.64.2.856-863.1990  0.305
1988 Homa FL, Glorioso JC, Levine M. A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene. Genes & Development. 2: 40-53. PMID 2833425 DOI: 10.1101/Gad.2.1.40  0.3
1988 Palella TD, Silverman LJ, Schroll CT, Homa FL, Levine M, Kelley WN. Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells. Molecular and Cellular Biology. 8: 457-60. PMID 2827006 DOI: 10.1128/Mcb.8.1.457  0.319
1987 Shapira M, Homa FL, Glorioso JC, Levine M. Regulation of the herpes simplex virus type 1 late (gamma 2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (alpha) 4 and 0 genes. Nucleic Acids Research. 15: 3097-111. PMID 3031620 DOI: 10.1093/Nar/15.7.3097  0.356
1986 Homa FL, Otal TM, Glorioso JC, Levine M. Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA. Molecular and Cellular Biology. 6: 3652-66. PMID 3025606 DOI: 10.1128/Mcb.6.11.3652  0.383
1986 Homa FL, Purifoy DJ, Glorioso JC, Levine M. Molecular basis of the glycoprotein C-negative phenotypes of herpes simplex virus type 1 mutants selected with a virus-neutralizing monoclonal antibody. Journal of Virology. 58: 281-9. PMID 3009845 DOI: 10.1128/Jvi.58.2.281-289.1986  0.356
1983 Homa FL, Bárány M. Phosphorylation of a 25,000-dalton protein in slow and fast muscles of the chicken. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 76: 801-10. PMID 6661900 DOI: 10.1016/0305-0491(83)90396-6  0.311
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