| Year |
Citation |
Score |
| 2017 |
Fritz-Laylin LK, Riel-Mehan M, Chen BC, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E, Mullins RD. Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes. Elife. 6. PMID 28948912 DOI: 10.7554/eLife.26990 |
1 |
|
| 2016 |
Hatch AL, Ji WK, Merrill RA, Strack S, Higgs HN. Actin filaments as dynamic reservoirs for Drp1 recruitment. Molecular Biology of the Cell. PMID 27559132 DOI: 10.1091/mbc.E16-03-0193 |
0.76 |
|
| 2016 |
Subramanian B, Sun H, Yan P, Charoonratana VT, Higgs HN, Wang F, Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, Pollak MR. Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury. Kidney International. PMID 27350175 DOI: 10.1016/j.kint.2016.04.020 |
1 |
|
| 2015 |
Ji WK, Hatch AL, Merrill RA, Strack S, Higgs HN. Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. Elife. 4. PMID 26609810 DOI: 10.7554/eLife.11553 |
1 |
|
| 2015 |
Young LE, Heimsath EG, Higgs HN. Cell type-dependent mechanisms for formin-mediated assembly of filopodia. Molecular Biology of the Cell. PMID 26446836 DOI: 10.1091/mbc.E15-09-0626 |
1 |
|
| 2015 |
Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, Spudich J, Lippincott-Schwartz J. A mitochondria-anchored isoform of the actin-nucleating Spire protein regulates mitochondrial division. Elife. 4. PMID 26305500 DOI: 10.7554/eLife.08828 |
1 |
|
| 2015 |
Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN. Assembly and Turnover of Short Actin Filaments by the Formin INF2 and Profilin. The Journal of Biological Chemistry. 290: 22494-506. PMID 26124273 DOI: 10.1074/jbc.M115.670166 |
1 |
|
| 2015 |
Gauvin TJ, Young LE, Higgs HN. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. Molecular Biology of the Cell. 26: 467-77. PMID 25428984 DOI: 10.1091/mbc.E14-07-1247 |
1 |
|
| 2014 |
Hatch AL, Gurel PS, Higgs HN. Novel roles for actin in mitochondrial fission. Journal of Cell Science. 127: 4549-60. PMID 25217628 DOI: 10.1242/jcs.153791 |
1 |
|
| 2014 |
Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF. Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR. Chemical Communications (Cambridge, England). 50: 12037-9. PMID 25170530 DOI: 10.1039/c4cc04399e |
1 |
|
| 2014 |
Gurel PS, Hatch AL, Higgs HN. Connecting the cytoskeleton to the endoplasmic reticulum and Golgi. Current Biology : Cb. 24: R660-72. PMID 25050967 DOI: 10.1016/j.cub.2014.05.033 |
1 |
|
| 2014 |
Sharma S, Grintsevich EE, Woo J, Gurel PS, Higgs HN, Reisler E, Gimzewski JK. Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 7533-9. PMID 24915113 DOI: 10.1021/la501748x |
1 |
|
| 2014 |
Korobova F, Gauvin TJ, Higgs HN. A role for myosin II in mammalian mitochondrial fission. Current Biology : Cb. 24: 409-14. PMID 24485837 DOI: 10.1016/j.cub.2013.12.032 |
1 |
|
| 2014 |
Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD. Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. Plos One. 9: e85090. PMID 24454796 DOI: 10.1371/journal.pone.0085090 |
1 |
|
| 2014 |
Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN. INF2-mediated severing through actin filament encirclement and disruption. Current Biology : Cb. 24: 156-64. PMID 24412206 DOI: 10.1016/j.cub.2013.12.018 |
1 |
|
| 2013 |
Ramabhadran V, Hatch AL, Higgs HN. Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction. The Journal of Biological Chemistry. 288: 26847-55. PMID 23921379 DOI: 10.1074/jbc.M113.472415 |
1 |
|
| 2013 |
Sun H, Schlondorff J, Higgs HN, Pollak MR. Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. Journal of the American Society of Nephrology : Jasn. 24: 917-29. PMID 23620398 DOI: 10.1681/ASN.2012080834 |
1 |
|
| 2013 |
Korobova F, Ramabhadran V, Higgs HN. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science (New York, N.Y.). 339: 464-7. PMID 23349293 DOI: 10.1126/science.1228360 |
1 |
|
| 2013 |
Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ. FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation. Nature Structural & Molecular Biology. 20: 111-8. PMID 23222643 DOI: 10.1038/nsmb.2462 |
1 |
|
| 2012 |
Ramabhadran V, Gurel PS, Higgs HN. Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing. The Journal of Biological Chemistry. 287: 34234-45. PMID 22879592 DOI: 10.1074/jbc.M112.365122 |
1 |
|
| 2012 |
Hager MH, Morley S, Bielenberg DR, Gao S, Morello M, Holcomb IN, Liu W, Mouneimne G, Demichelis F, Kim J, Solomon KR, Adam RM, Isaacs WB, Higgs HN, Vessella RL, et al. DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. Embo Molecular Medicine. 4: 743-60. PMID 22593025 DOI: 10.1002/emmm.201200242 |
1 |
|
| 2012 |
Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. Journal of Cell Science. 125: 1420-8. PMID 22275430 DOI: 10.1242/jcs.091066 |
1 |
|
| 2012 |
Heimsath EG, Higgs HN. The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends. The Journal of Biological Chemistry. 287: 3087-98. PMID 22094460 DOI: 10.1074/jbc.M111.312207 |
1 |
|
| 2011 |
Gaillard J, Ramabhadran V, Neumanne E, Gurel P, Blanchoin L, Vantard M, Higgs HN. Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules. Molecular Biology of the Cell. 22: 4575-87. PMID 21998204 DOI: 10.1091/mbc.E11-07-0616 |
1 |
|
| 2011 |
Ramabhadran V, Korobova F, Rahme GJ, Higgs HN. Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. Molecular Biology of the Cell. 22: 4822-33. PMID 21998196 DOI: 10.1091/mbc.E11-05-0457 |
1 |
|
| 2011 |
Sun H, Schlondorff JS, Brown EJ, Higgs HN, Pollak MR. Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2). Proceedings of the National Academy of Sciences of the United States of America. 108: 2933-8. PMID 21278336 DOI: 10.1073/pnas.1017010108 |
1 |
|
| 2011 |
Mason FM, Heimsath EG, Higgs HN, Soderling SH. Bi-modal regulation of a formin by srGAP2. The Journal of Biological Chemistry. 286: 6577-86. PMID 21148482 DOI: 10.1074/jbc.M110.190397 |
1 |
|
| 2011 |
Higgs HN. Discussing the morphology of actin filaments in lamellipodia. Trends in Cell Biology. 21: 2-4; author reply 4-. PMID 20971009 DOI: 10.1016/j.tcb.2010.09.010 |
1 |
|
| 2010 |
Chang CC, Miyazaki A, Dong R, Kheirollah A, Yu C, Geng Y, Higgs HN, Chang TY. Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy. Biochemistry. 49: 9957-63. PMID 20964445 DOI: 10.1021/bi1013936 |
1 |
|
| 2010 |
Harris ES, Gauvin TJ, Heimsath EG, Higgs HN. Assembly of filopodia by the formin FRL2 (FMNL3). Cytoskeleton (Hoboken, N.J.). 67: 755-72. PMID 20862687 DOI: 10.1002/cm.20485 |
1 |
|
| 2010 |
Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nature Genetics. 42: 72-6. PMID 20023659 DOI: 10.1038/ng.505 |
1 |
|
| 2009 |
Gauvin TJ, Fukui J, Peterson JR, Higgs HN. Isoform-selective chemical inhibition of mDia-mediated actin assembly. Biochemistry. 48: 9327-9. PMID 19764708 DOI: 10.1021/bi901354z |
1 |
|
| 2009 |
Chhabra ES, Ramabhadran V, Gerber SA, Higgs HN. INF2 is an endoplasmic reticulum-associated formin protein. Journal of Cell Science. 122: 1430-40. PMID 19366733 DOI: 10.1242/jcs.040691 |
1 |
|
| 2008 |
Esue O, Harris ES, Higgs HN, Wirtz D. The filamentous actin cross-linking/bundling activity of mammalian formins. Journal of Molecular Biology. 384: 324-34. PMID 18835565 DOI: 10.1016/j.jmb.2008.09.043 |
1 |
|
| 2008 |
Nicholson-Dykstra SM, Higgs HN. Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes. Cell Motility and the Cytoskeleton. 65: 904-22. PMID 18720401 DOI: 10.1002/cm.20312 |
1 |
|
| 2007 |
Chhabra ES, Higgs HN. The many faces of actin: matching assembly factors with cellular structures. Nature Cell Biology. 9: 1110-21. PMID 17909522 DOI: 10.1038/ncb1007-1110 |
1 |
|
| 2007 |
Wawro B, Greenfield NJ, Wear MA, Cooper JA, Higgs HN, Hitchcock-DeGregori SE. Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament. Biochemistry. 46: 8146-55. PMID 17569543 DOI: 10.1021/bi700686p |
1 |
|
| 2007 |
Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS. Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. Current Biology : Cb. 17: 579-91. PMID 17398099 DOI: 10.1016/j.cub.2007.03.024 |
1 |
|
| 2007 |
Amiel E, Nicholson-Dykstra S, Walters JJ, Higgs H, Berwin B. Scavenger receptor-A functions in phagocytosis of E. coli by bone marrow dendritic cells. Experimental Cell Research. 313: 1438-48. PMID 17362929 DOI: 10.1016/j.yexcr.2007.02.011 |
1 |
|
| 2006 |
Chhabra ES, Higgs HN. INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization. The Journal of Biological Chemistry. 281: 26754-67. PMID 16818491 DOI: 10.1074/jbc.M604666200 |
1 |
|
| 2006 |
Harris ES, Rouiller I, Hanein D, Higgs HN. Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2. The Journal of Biological Chemistry. 281: 14383-92. PMID 16556604 DOI: 10.1074/jbc.M510923200 |
1 |
|
| 2006 |
Harris ES, Higgs HN. Biochemical analysis of mammalian formin effects on actin dynamics. Methods in Enzymology. 406: 190-214. PMID 16472659 DOI: 10.1016/S0076-6879(06)06015-0 |
1 |
|
| 2006 |
Kovar DR, Harris ES, Mahaffy R, Higgs HN, Pollard TD. Control of the assembly of ATP- and ADP-actin by formins and profilin. Cell. 124: 423-35. PMID 16439214 DOI: 10.1016/j.cell.2005.11.038 |
1 |
|
| 2005 |
Higgs HN. Formin proteins: a domain-based approach. Trends in Biochemical Sciences. 30: 342-53. PMID 15950879 DOI: 10.1016/j.tibs.2005.04.014 |
1 |
|
| 2005 |
Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB, Schafer DA. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. The Journal of Biological Chemistry. 280: 28653-62. PMID 15939738 DOI: 10.1074/jbc.M503957200 |
1 |
|
| 2005 |
Nicholson-Dykstra S, Higgs HN, Harris ES. Actin dynamics: growth from dendritic branches. Current Biology : Cb. 15: R346-57. PMID 15886095 DOI: 10.1016/j.cub.2005.04.029 |
1 |
|
| 2005 |
Li F, Higgs HN. Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1. The Journal of Biological Chemistry. 280: 6986-92. PMID 15591319 DOI: 10.1074/jbc.M411605200 |
1 |
|
| 2005 |
Higgs HN, Peterson KJ. Phylogenetic analysis of the formin homology 2 domain. Molecular Biology of the Cell. 16: 1-13. PMID 15509653 DOI: 10.1091/mbc.E04-07-0565 |
1 |
|
| 2004 |
Higgs HN. There goes the neighbourhood: Eps8 joins the barbed-end crowd. Nature Cell Biology. 6: 1147-9. PMID 15573090 DOI: 10.1038/ncb1204-1147 |
1 |
|
| 2004 |
Harris ES, Higgs HN. Actin cytoskeleton: formins lead the way. Current Biology : Cb. 14: R520-2. PMID 15242634 DOI: 10.1016/j.cub.2004.06.043 |
1 |
|
| 2004 |
Majstoravich S, Zhang J, Nicholson-Dykstra S, Linder S, Friedrich W, Siminovitch KA, Higgs HN. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood. 104: 1396-403. PMID 15130947 DOI: 10.1182/blood-2004-02-0437 |
1 |
|
| 2004 |
Harris ES, Li F, Higgs HN. The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments. The Journal of Biological Chemistry. 279: 20076-87. PMID 14990563 DOI: 10.1074/jbc.M312718200 |
1 |
|
| 2003 |
Li F, Higgs HN. The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Current Biology : Cb. 13: 1335-40. PMID 12906795 DOI: 10.1016/S0960-9822(03)00540-2 |
1 |
|
| 2003 |
Merz AJ, Higgs HN. Listeria motility: biophysics pushes things forward. Current Biology : Cb. 13: R302-4. PMID 12699639 DOI: 10.1016/S0960-9822(03)00231-8 |
1 |
|
| 2002 |
Higgs HN. Actin nucleation: cortactin caught in the act. Current Biology : Cb. 12: R593-5. PMID 12225681 DOI: 10.1016/S0960-9822(02)01101-6 |
1 |
|
| 2001 |
Higgs HN. Actin nucleation: Nucleation-promoting factors are not all equal Current Biology. 11. PMID 11747836 DOI: 10.1016/S0960-9822(01)00612-1 |
1 |
|
| 2001 |
Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD. Crystal structure of Arp2/3 complex. Science (New York, N.Y.). 294: 1679-84. PMID 11721045 DOI: 10.1126/science.1066333 |
1 |
|
| 2001 |
Hüfner K, Higgs HN, Pollard TD, Jacobi C, Aepfelbacher M, Linder S. The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complex-dependent actin nucleation. The Journal of Biological Chemistry. 276: 35761-7. PMID 11459849 DOI: 10.1074/jbc.M106520200 |
1 |
|
| 2001 |
Higgs HN, Pollard TD. Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins Annual Review of Biochemistry. 70: 649-676. PMID 11395419 DOI: 10.1146/annurev.biochem.70.1.649 |
1 |
|
| 2001 |
Marchand JB, Kaiser DA, Pollard TD, Higgs HN. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex Nature Cell Biology. 3: 76-82. PMID 11146629 DOI: 10.1038/35050590 |
1 |
|
| 2001 |
Higgs HN. The basic art of protein-membrane interaction specificity: MARCKS and PIP2 Trends in Biochemical Sciences. 26: 12-13. |
1 |
|
| 2001 |
Higgs HN. Spectres of spectrin: Molecular modeling and hemolytic disease Trends in Biochemical Sciences. 26: 702. |
1 |
|
| 2000 |
Higgs HN, Pollard TD. Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex Journal of Cell Biology. 150: 1311-1320. PMID 10995437 DOI: 10.1083/jcb.150.6.1311 |
1 |
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| 2000 |
Higgs HN. The harder the better: Effects of substrate rigidity on cell motility Trends in Biochemical Sciences. 25: 427. PMID 10986457 |
1 |
|
| 2000 |
Lin Q, Higgs HN, Glomset JA. Membrane lipids have multiple effects on interfacial catalysis by a phosphatidic acid-preferring phospholipase A1 from bovine testis Biochemistry. 39: 9335-9344. PMID 10924127 DOI: 10.1021/bi000017u |
1 |
|
| 2000 |
Blancholn L, Amann KJ, Higgs HN, Marchand JB, Kaiser DA, Pollard TD. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins Nature. 404: 1007-1011. PMID 10801131 DOI: 10.1038/35010008 |
1 |
|
| 2000 |
Higgs HN. Tools for 'The Sceptical Chymist': Measuring macromolecular interaction kinetics in live cells by TIR-FRAP Trends in Biochemical Sciences. 25: 540-541. |
1 |
|
| 1999 |
Higgs HN, Blanchoin L, Pollard TD. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization Biochemistry. 38: 15212-15222. PMID 10563804 DOI: 10.1021/bi991843+ |
1 |
|
| 1999 |
Higgs HN, Pollard TD. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins Journal of Biological Chemistry. 274: 32531-32534. PMID 10551802 DOI: 10.1074/jbc.274.46.32531 |
1 |
|
| 1999 |
Huang M, Yang C, Schafer DA, Cooper JA, Higgs HN, Zigmond SH. Cdc42-induced actin filaments are protected from capping protein. Current Biology : Cb. 9: 979-82. PMID 10508585 DOI: 10.1016/S0960-9822(99)80428-X |
1 |
|
| 1999 |
May RC, Hall ME, Higgs HN, Pollard TD, Chakraborty T, Wehland J, Machesky LM, Sechi AS. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes Current Biology. 9: 759-762. PMID 10421578 DOI: 10.1016/S0960-9822(99)80337-6 |
1 |
|
| 1999 |
Machesky LM, Mullins RD, Higgs HN, Kaiser DA, Blanchoin L, May RC, Hall ME, Pollard TD. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proceedings of the National Academy of Sciences of the United States of America. 96: 3739-44. PMID 10097107 DOI: 10.1073/pnas.96.7.3739 |
1 |
|
| 1998 |
Vinson VK, De La Cruz EM, Higgs HN, Pollard TD. Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin. Biochemistry. 37: 10871-80. PMID 9692980 DOI: 10.1021/bi980093l |
1 |
|
| 1998 |
Higgs HN, Han MH, Johnson GE, Glomset JA. Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis. The Journal of Biological Chemistry. 273: 5468-77. PMID 9488669 DOI: 10.1074/jbc.273.10.5468 |
1 |
|
| 1996 |
Higgs HN, Glomset JA. Purification and properties of a phosphatidic acid-preferring phospholipase A1 from bovine testis: Examination of the molecular basis of its activation Journal of Biological Chemistry. 271: 10874-10883. PMID 8631903 DOI: 10.1074/jbc.271.18.10874 |
1 |
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| 1994 |
Higgs HN, Glomset JA. Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis Proceedings of the National Academy of Sciences of the United States of America. 91: 9574-9578. PMID 7937808 |
1 |
|
| 1989 |
Lubahn DB, Brown TR, Simental JA, Higgs HN, Migeon CJ, Wilson EM, French FS. Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proceedings of the National Academy of Sciences of the United States of America. 86: 9534-8. PMID 2594783 DOI: 10.1073/pnas.86.23.9534 |
1 |
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| 1988 |
Lubahn DB, Joseph DR, Sar M, Tan J, Higgs HN, Larson RE, French FS, Wilson EM. The human androgen receptor: Complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate Molecular Endocrinology. 2: 1265-1275. PMID 3216866 |
1 |
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