Jordan Tang - Publications

Affiliations: 
University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States 
Area:
Biochemistry

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wu H, Castenheira P, Faro C, Tang J. Cardosin A Endocytosis Mediated by Integrin Leads to Lysosome Leakage and Apoptosis of Epithelial Cells. Proteins. PMID 30785216 DOI: 10.1002/prot.25672  0.56
2019 Ghosh AK, Brindisi M, Yen YC, Lendy EK, Kovela S, Cárdenas EL, Reddy BS, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. Chemmedchem. PMID 30637955 DOI: 10.1002/cmdc.201800725  0.4
2018 Ghosh AK, Ghosh K, Brindisi M, Lendy EK, Yen YC, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. PMID 29970308 DOI: 10.1016/j.bmcl.2018.06.045  0.4
2017 Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28427814 DOI: 10.1016/j.bmcl.2017.04.011  0.4
2016 Chai S, Qian Y, Tang J, Liang Z, Zhang M, Si J, Li X, Huang W, Xu R, Wang K. Corrigendum to 'Ca(2+)/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer' [Cancer Lett. 344 (1), 119-128; March 1, 2014]. Cancer Letters. PMID 27491000 DOI: 10.1016/j.canlet.2016.07.026  0.68
2016 Tang JQ, Ma QF, Shi JT, Yuan HF, Song CF, Xie JC, Li XY. [Rapid FTIR-ATR Method for the Quantification of Bitumen Property]. Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu. 36: 672-5. PMID 27400503  0.6
2016 Li X, Liang L, De Vivo I, Tang JY, Han J. Pathway analysis of expression-related SNPs on genome-wide association study of basal cell carcinoma. Oncotarget. PMID 27367190 DOI: 10.18632/oncotarget.9212  0.68
2016 Zhang Y, Tang J, Yang N, Liu Q, Zhang Q, Zhang Y, Li N, Zhao Y, Li S, Liu S, Zhou H, Li X, Tian M, Deng J, Xie P, et al. FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN. Journal of Immunology (Baltimore, Md. : 1950). PMID 27354218 DOI: 10.4049/jimmunol.1501563  0.68
2016 Ghosh AK, Reddy BS, Yen YC, Cardenas E, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chemical Science (Royal Society of Chemistry : 2010). 7: 3117-3122. PMID 27347366 DOI: 10.1039/C5SC03718B  0.4
2016 Tang J, Yang R, Lv L, Yao A, Pu L, Yin A, Li X, Yu Y, Nyberg SL, Wang X. TGF-β-expressing Mesenchymal Stem Cells Induce Local Tolerance in a Rat Liver Transplantation Model of Acute Rejection. Stem Cells (Dayton, Ohio). PMID 27333806 DOI: 10.1002/stem.2437  0.68
2016 Xiao Z, Tang F, Tang J, Yang H, Zhao Y, Chen B, Han S, Wang N, Li X, Cheng S, Han G, Zhao C, Yang X, Chen Y, Shi Q, et al. One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Science China. Life Sciences. PMID 27333785 DOI: 10.1007/s11427-016-5080-z  0.52
2016 Hu D, Li C, Sun L, Zhou C, Li X, Ai Z, Tang J, Peng A. A modified nontransposed brachiobasilic arteriovenous fistula versus brachiocephalic arteriovenous fistula for maintenance hemodialysis access. Journal of Vascular Surgery. PMID 27296523 DOI: 10.1016/j.jvs.2016.03.450  0.48
2016 Feng W, Li J, Han S, Tang J, Yao J, Cui Y, Wang C, Chen Z, Li X, Zhi X. [CT Guided Radiofrequency Ablation Followed Intratumoral Chemotherapy 
in the Treatment of Early Stage Non-small Cell Lung Cancer]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer. 19: 269-78. PMID 27215455 DOI: 10.3779/j.issn.1009-3419.2016.05.04  0.68
2016 Wu J, Zhao L, Zhang L, Li XL, Guo M, Tang J. Metallosupramolecular Coordination Complexes: The Design of Heterometallic 3d-4f Gridlike Structures. Inorganic Chemistry. PMID 27195580 DOI: 10.1021/acs.inorgchem.6b00529  0.56
2016 Li X, Yin Y, Deng J, Zhong H, Tang J, Chen Z, Yang L, Ma LJ. A solvent-dependent fluorescent detection method for Fe(3+) and Hg(2+) based on a rhodamine B derivative. Talanta. 154: 329-34. PMID 27154682 DOI: 10.1016/j.talanta.2016.03.090  0.68
2016 Li GH, Luo B, Lv YX, Zheng F, Wang L, Wei MX, Li XY, Zhang L, Wang JN, Chen SY, Tang JM, He X. Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia-reperfusion injury. Journal of Translational Medicine. 14: 116. PMID 27146579 DOI: 10.1186/s12967-016-0847-3  0.56
2016 Wang L, Li M, Tang J, Li X. Eremophilane Sesquiterpenes from a Deep Marine-Derived Fungus, Aspergillus sp. SCSIOW2, Cultivated in the Presence of Epigenetic Modifying Agents. Molecules (Basel, Switzerland). 21. PMID 27096861 DOI: 10.3390/molecules21040473  0.68
2016 Yan J, Gopaul R, Wen J, Li XS, Tang JF. The natural progression of VGAMs and the need for urgent medical attention: a systematic review and meta-analysis. Journal of Neurointerventional Surgery. PMID 27091749 DOI: 10.1136/neurintsurg-2015-012212  0.4
2016 Lin H, Lin D, Long E, Jiang H, Qu B, Tang J, Lin Y, Chen J, Wu X, Lin Z, Li X, Liu Z, Zhang B, Chen H, Tan X, et al. Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China. Bmj Open. 6: e011061. PMID 27084286 DOI: 10.1136/bmjopen-2016-011061  0.68
2016 Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Notte GT, Kalla R, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Smith-Maxwell C, Dhalla AK, Rajamani S, Stafford B, ... Tang J, et al. Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine. Bioorganic & Medicinal Chemistry Letters. PMID 27080178 DOI: 10.1016/j.bmcl.2016.03.101  0.36
2016 Li X, Li J, Wen H, Ju X, Chen X, Xia L, Ke G, Tang J, Wu X. The Survival Rate and Surgical Morbidity of Abdominal Radical Trachelectomy Versus Abdominal Radical Hysterectomy for Stage IB1 Cervical Cancer. Annals of Surgical Oncology. PMID 27044448 DOI: 10.1245/s10434-016-5216-1  0.76
2016 Wang D, Yang L, Zhu W, Zhang Y, Zou S, Bo H, Gao R, Dong J, Huang W, Guo J, Li Z, Zhao X, Li X, Xin L, Zhou J, ... ... Tang J, et al. Two outbreak sources of influenza A (H7N9) viruses have been established in China. Journal of Virology. PMID 27030268 DOI: 10.1128/JVI.03173-15  0.48
2016 Liang Y, Cao C, Zhu C, Wang C, Zhang C, Dong F, Yang F, Deng H, Yu J, Tang J, Su L, Xin L, Hong L, Gao M, Tang M, et al. The effectiveness and safety of amisulpride in Chinese patients with schizophrenia: An 8-week, prospective, open-label, multicenter, single-arm study. Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists. PMID 27020720 DOI: 10.1111/appy.12238  0.68
2016 Li Z, Wei W, Chen B, Cai G, Li X, Wang P, Tang J, Dong W. The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat. Scientific Reports. 6: 23508. PMID 27006085 DOI: 10.1038/srep23508  0.32
2016 Li X, Tang Y, Yang J, Wen X, Guo J, Tang J, Du X, Su N, Chen L. Deletion of Fibroblast Growth Factor Receptor 3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26990430 DOI: 10.1002/jbmr.2839  0.44
2016 Li XY, Feng XZ, Tang JZ, Dong K, Wang JF, Meng CC, Wang J, Mo YW, Sun ZW. MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a. Molecular Medicine Reports. PMID 26986232 DOI: 10.3892/mmr.2016.4995  0.44
2016 Li X, Ding C, Liao J, Du L, Sun Q, Yang J, Yang Y, Zhang D, Tang J, Liu N. Bioaccumulation characterization of uranium by a novel Streptomyces sporoverrucosus dwc-3. Journal of Environmental Sciences (China). 41: 162-71. PMID 26969062 DOI: 10.1016/j.jes.2015.06.007  0.68
2016 Zhang C, Tang J, Liu D, Li X, Cheng L, Tang X. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. International Journal of Pharmaceutics. PMID 26943975 DOI: 10.1016/j.ijpharm.2016.02.045  0.52
2016 Li X, Ma Y, Chen T, Tang J, Ma X. [Unfractionated heparin inhibits lipopolysaccharide-induced expression of chemokines in human endothelial cells through nuclear factor-ΚB signaling pathway]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 28: 117-21. PMID 26911942 DOI: 10.3760/cma.j.issn.2095-4352.2016.02.007  0.68
2016 Zhao M, Deng Z, Tang J, Zhou X, Chen Z, Li X, Yang L, Ma LJ. 2-(1-Pyrenyl) benzimidazole as a ratiometric and "turn-on" fluorescent probe for iron(iii) ions in aqueous solution. The Analyst. PMID 26899673 DOI: 10.1039/c5an02565f  0.32
2016 Tian JF, Li PJ, Li XX, Sun PH, Gao H, Liu XZ, Huang P, Tang JS, Yao XS. New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae. Bioorganic & Medicinal Chemistry Letters. PMID 26848110 DOI: 10.1016/j.bmcl.2016.01.074  0.32
2016 Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Schizophrenia Research. PMID 26822593 DOI: 10.1016/j.schres.2016.01.011  0.68
2016 Zhou M, Zhang Y, Li X, Wang Z, Tang J, Mu Y, Fang C, Chen X, Dai J. Complete genome sequence of Kocuria flava strain HO-9041, a heavy metal removal bacterium from Xinjiang. Journal of Biotechnology. PMID 26795688 DOI: 10.1016/j.jbiotec.2016.01.004  0.64
2016 Chen XG, Lv YX, Zhao D, Zhang L, Zheng F, Yang JY, Li XL, Wang L, Guo LY, Pan YM, Yan YW, Chen SY, Wang JN, Tang JM, Wan Y. Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. Molecular and Cellular Biochemistry. PMID 26769665 DOI: 10.1007/s11010-015-2622-9  0.56
2016 Li X, Ma Y, Tang J, Chen T, Ma X. A Hemophagocytic Lymphohistiocytosis Patient that Presented With Unilateral Panuveitis. Ocular Immunology and Inflammation. 1-3. PMID 26731243 DOI: 10.3109/09273948.2015.1107593  0.68
2016 Liu X, Ma G, Zhao Z, Mao F, Tang J, Li X, Zhu M. Novel mutation of SLC20A2 in a Chinese family with primary familial brain calcification. Journal of the Neurological Sciences. 360: 1-3. PMID 26723961 DOI: 10.1016/j.jns.2015.11.036  0.52
2015 Ma X, Wang Q, Li X, Tang J, Zhang Z. Determination of the solubility parameter of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate by inverse gas chromatography. SE Pu = Chinese Journal of Chromatography / Zhongguo Hua Xue Hui. 33: 1192-8. PMID 26939366  0.68
2015 Tang J, Li XY, Wu H, Ren LJ, Zhang YQ, Yao HX, Hu MB, Wang W. Tube-graft-Sheet Nano-Objects Created by A Stepwise Self-Assembly of Polymer-Polyoxometalate Hybrids. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 26710830 DOI: 10.1021/acs.langmuir.5b04504  0.56
2015 Cheng G, Hu R, Ye L, Wang B, Gui Y, Gao S, Li X, Tang J. Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. Aaps Pharmscitech. PMID 26694058 DOI: 10.1208/s12249-015-0469-8  0.44
2015 Wang WG, Li A, Yan BC, Niu SB, Tang JW, Li XN, Du X, Challis GL, Che Y, Sun HD, Pu JX. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18. Journal of Natural Products. PMID 26677752 DOI: 10.1021/acs.jnatprod.5b00814  0.48
2015 Tang JJ, Meng QY, Cai ZX, Li XQ. Transplantation of VEGFl65-overexpressing vascular endothelial progenitor cells relieves endothelial injury after deep vein thrombectomy. Thrombosis Research. PMID 26632512 DOI: 10.1016/j.thromres.2015.11.025  0.48
2015 Zhou M, Li XR, Tang JW, Liu Y, Li XN, Wu B, Qin HB, Du X, Li LM, Wang WG, Pu JX, Sun HD. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2 + 2] Cycloaddition and C-H Functionalization. Organic Letters. PMID 26617269 DOI: 10.1021/acs.orglett.5b03079  0.48
2015 Zhang Y, Yu C, Zhou M, Tang J, Li X, Wang Z, Li Z, Yao J, Li P, Zheng G, Chen X, Dai J. Complete Genome Sequence of Rufibacter tibetensis Strain 1351, a Radiation-resistant Bacterium from Tibet plateau. Journal of Biotechnology. PMID 26598420 DOI: 10.1016/j.jbiotec.2015.10.015  0.76
2015 Ghosh AK, Tang J. Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease. Chemmedchem. 10: 1463-6. PMID 26140607 DOI: 10.1002/cmdc.201500216  0.32
2015 Ghosh AK, Brindisi M, Yen YC, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. 25: 668-72. PMID 25537272 DOI: 10.1016/j.bmcl.2014.11.087  0.8
2014 Tang J, Liang G, Chen X. [A patient with acute mononuclear leukemia 9 months after bone marrow necrosis]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. 35: 39. PMID 24602730 DOI: 10.3760/cma.j.issn.0253-2727.2014.01.010  0.76
2013 Li X, Hong L, Coughlan K, Wang L, Cao L, Tang J. Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease. Acta Biochimica Et Biophysica Sinica. 45: 613-21. PMID 23676825 DOI: 10.1093/abbs/gmt050  0.68
2013 Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochimica Et Biophysica Acta. 1833: 1562-71. PMID 23517619 DOI: 10.1016/j.bbamcr.2013.03.003  0.48
2013 Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2132-44. PMID 23430844 DOI: 10.1096/fj.12-214353  0.8
2012 Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 55: 9195-207. PMID 22954357 DOI: 10.1021/jm3008823  0.8
2012 Ghosh AK, Pandey S, Gangarajula S, Kulkarni S, Xu X, Rao KV, Huang X, Tang J. Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 5460-5. PMID 22863204 DOI: 10.1016/j.bmcl.2012.07.043  0.8
2012 Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Applied Microbiology and Biotechnology. 94: 1041-9. PMID 22270239 DOI: 10.1007/s00253-012-3893-7  0.8
2012 Ghosh AK, Brindisi M, Tang J. Developing β-secretase inhibitors for treatment of Alzheimer's disease. Journal of Neurochemistry. 120: 71-83. PMID 22122681 DOI: 10.1111/j.1471-4159.2011.07476.x  0.8
2011 Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochemical and Biophysical Research Communications. 407: 400-5. PMID 21396916 DOI: 10.1016/j.bbrc.2011.03.033  0.8
2011 Tang J, Ghosh A. Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned? Aging. 3: 14-16. PMID 21248377  0.8
2011 Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 775-84. PMID 21059748 DOI: 10.1096/fj.10-167213  0.8
2010 Li X, Bo H, Zhang XC, Hartsuck JA, Tang J. Predicting memapsin 2 (β-secretase) hydrolytic activity. Protein Science : a Publication of the Protein Society. 19: 2175-85. PMID 20853423 DOI: 10.1002/pro.502  0.68
2009 Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. Journal of Medicinal Chemistry. 52: 7689-705. PMID 19746963 DOI: 10.1021/jm900695w  0.8
2009 Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/j.brainres.2009.01.008  0.8
2008 Ghosh AK, Gemma S, Tang J. beta-Secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 399-408. PMID 18625451 DOI: 10.1016/j.nurt.2008.05.007  0.32
2008 Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Memapsin 2 (beta-secretase) inhibitors: drug development. Current Alzheimer Research. 5: 121-31. PMID 18393797  0.48
2008 Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorganic & Medicinal Chemistry Letters. 18: 1031-6. PMID 18180160 DOI: 10.1016/j.bmcl.2007.12.028  0.8
2007 Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Current Alzheimer Research. 4: 418-22. PMID 17908045  0.8
2007 Chang WP, Downs D, Huang XP, Da H, Fung KM, Tang J. Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3184-96. PMID 17494994 DOI: 10.1096/fj.06-7993com  0.8
2007 Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. Journal of Medicinal Chemistry. 50: 2399-407. PMID 17432843 DOI: 10.1021/jm061338s  0.8
2007 He X, Cooley K, Chung CH, Dashti N, Tang J. Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4052-60. PMID 17428983 DOI: 10.1523/JNEUROSCI.3993-06.2007  0.4
2006 Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. Journal of the American Chemical Society. 128: 5310-1. PMID 16620080 DOI: 10.1021/ja058636j  0.8
2005 Ghosh AK, Kumaragurubaran N, Tang J. Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease. Current Topics in Medicinal Chemistry. 5: 1609-22. PMID 16375745  0.32
2005 Tang J, He X, Huang X, Hong L. Recent developments on the studies of human memapsin 2 (beta-secretase). Current Alzheimer Research. 2: 261-4. PMID 15974927  0.48
2005 Turner RT, Hong L, Koelsch G, Ghosh AK, Tang J. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry. 44: 105-12. PMID 15628850 DOI: 10.1021/bi048106k  0.8
2005 He X, Li F, Chang WP, Tang J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). The Journal of Biological Chemistry. 280: 11696-703. PMID 15615712 DOI: 10.1074/jbc.M411296200  0.4
2005 Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorganic & Medicinal Chemistry Letters. 15: 15-20. PMID 15582402 DOI: 10.1016/j.bmcl.2004.10.084  0.8
2004 Hong L, He X, Huang X, Chang W, Tang J. Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications. Acta Biochimica Et Biophysica Sinica. 36: 787-92. PMID 15592644  0.48
2004 Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. The Embo Journal. 23: 3909-17. PMID 15457209 DOI: 10.1038/sj.emboj.7600411  0.68
2004 Kzhyshkowska J, Gratchev A, Martens JH, Pervushina O, Mamidi S, Johansson S, Schledzewski K, Hansen B, He X, Tang J, Nakayama K, Goerdt S. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. Journal of Leukocyte Biology. 76: 1151-61. PMID 15345724 DOI: 10.1189/jlb.0504300  0.4
2004 Huang XP, Chang WP, Koelsch G, Turner RT, Lupu F, Tang J. Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. The Journal of Biological Chemistry. 279: 37886-94. PMID 15197182 DOI: 10.1074/jbc.M402130200  0.8
2004 Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors. Journal of Neurochemistry. 89: 1409-16. PMID 15189343 DOI: 10.1111/j.1471-4159.2004.02452.x  0.8
2004 Hong L, Tang J. Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis. Biochemistry. 43: 4689-95. PMID 15096037 DOI: 10.1021/bi0498252  0.48
2003 Zhai P, He X, Liu J, Wakeham N, Zhu G, Li G, Tang J, Zhang XC. The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. Biochemistry. 42: 13901-8. PMID 14636058 DOI: 10.1021/bi035392b  0.8
2003 Koelsch G, Turner RT, Hong L, Ghosh AK, Tang J. Memapsin 2, a drug target for Alzheimer's disease. Biochemical Society Symposium. 213-20. PMID 14587294  0.8
2003 He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 42: 12174-80. PMID 14567678 DOI: 10.1021/bi035199h  0.8
2003 Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT, Chang W. Study of memapsin 2 (beta-secretase) and strategy of inhibitor design. Journal of Molecular Neuroscience : Mn. 20: 299-304. PMID 14501012 DOI: 10.1385/JMN:20:3:299  0.8
2003 Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. Crystal structure of the human GGA1 GAT domain. Biochemistry. 42: 6392-9. PMID 12767220 DOI: 10.1021/bi034334n  0.8
2003 Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. Febs Letters. 537: 171-6. PMID 12606052 DOI: 10.1016/S0014-5793(03)00095-4  0.8
2002 Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC. Effects of deletion of streptokinase residues 48-59 on plasminogen activation. Protein Engineering. 15: 753-61. PMID 12456874  0.8
2002 Hong L, Turner RT, Koelsch G, Shin D, Ghosh AK, Tang J. Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. Biochemistry. 41: 10963-7. PMID 12206667  0.8
2002 He X, Chang WP, Koelsch G, Tang J. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. Febs Letters. 524: 183-7. PMID 12135764  0.8
2002 Turner RT, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity. Biochemistry. 41: 8742-6. PMID 12093293 DOI: 10.1021/bi025926t  0.8
2002 Ghosh AK, Hong L, Tang J. Beta-secretase as a therapeutic target for inhibitor drugs. Current Medicinal Chemistry. 9: 1135-44. PMID 12052177  0.48
2002 Sun A, Koelsch G, Tang J, Bing G. Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls. Experimental Neurology. 175: 10-22. PMID 12009756 DOI: 10.1006/exnr.2002.7875  0.8
2001 Loy JA, Lin X, Schenone M, Castellino FJ, Zhang XC, Tang J. Domain interactions between streptokinase and human plasminogen. Biochemistry. 40: 14686-95. PMID 11724583 DOI: 10.1021/bi011309d  0.8
2001 Ghosh AK, Bilcer G, Harwood C, Kawahama R, Shin D, Hussain KA, Hong L, Loy JA, Nguyen C, Koelsch G, Ermolieff J, Tang J. Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). Journal of Medicinal Chemistry. 44: 2865-8. PMID 11520194 DOI: 10.1021/jm0101803  0.8
2000 Ghosh AK, Shin D, Downs D, Koelsch G, Lin X, Ermolieff J, Tang J. Design of Potent Inhibitors for Human Brain Memapsin 2 (-Secretase). Journal of the American Chemical Society. 122: 3522-3523. PMID 30443047 DOI: 10.1021/ja000300g  0.8
2000 Ermolieff J, Loy JA, Koelsch G, Tang J. Proteolytic activation of recombinant pro-memapsin 2 (Pro-beta-secretase) studied with new fluorogenic substrates Biochemistry. 39: 16263. PMID 11123957  0.8
2000 Ermolieff J, Loy JA, Koelsch G, Tang J. Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates. Biochemistry. 39: 12450-6. PMID 11015226 DOI: 10.1021/bi001494f  0.8
2000 Koelsch G, Tang J, Loy JA, Monod M, Jackson K, Foundling SI, Lin X. Enzymic characteristics of secreted aspartic proteases of Candida albicans. Biochimica Et Biophysica Acta. 1480: 117-31. PMID 11004559 DOI: 10.1016/S0167-4838(00)00068-6  0.8
2000 Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. Journal of Molecular Biology. 295: 903-14. PMID 10656799 DOI: 10.1006/jmbi.1999.3397  0.8
1998 Wang X, Lin X, Loy JA, Tang J, Zhang XC. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. Science (New York, N.Y.). 281: 1662-5. PMID 9733510 DOI: 10.1126/science.281.5383.1662  0.8
1995 Lin X, Koelsch G, Loy JA, Tang J. Rearranging the domains of pepsinogen. Protein Science : a Publication of the Protein Society. 4: 159-66. PMID 7757006 DOI: 10.1002/pro.5560040203  0.8
1993 Lin X, Loy JA, Sussman F, Tang J. Conformational instability of the N- and C-terminal lobes of porcine pepsin in neutral and alkaline solutions. Protein Science : a Publication of the Protein Society. 2: 1383-90. PMID 8401224 DOI: 10.1002/pro.5560020903  0.8
1979 Tang J. Evolution in the structure and function of carboxyl proteases Molecular and Cellular Biochemistry. 26: 93-109. PMID 388185 DOI: 10.1007/BF00232887  0.8
1977 Tang J. Acid proteases come of age Nature. 266: 119-120. DOI: 10.1038/266119a0  0.8
1976 Tang J. Pepsin and pepsinogen: models for carboxyl (acid) proteases and their zymogens Trends in Biochemical Sciences. 1: 205-208. DOI: 10.1016/0968-0004(76)90388-1  0.8
1971 Tang J. Specific and irreversible inactivation of pepsin by substrate-like epoxides Journal of Biological Chemistry. 246: 4510-4517. PMID 4937130  0.8
1970 Tang J. Amino acid sequence near the amino terminus of porcine pepsin Biochemical and Biophysical Research Communications. 41: 697-703. PMID 4920872 DOI: 10.1016/0006-291X(70)90069-0  0.8
1970 Tang J. [27] Gastricsin and Pepsin Methods in Enzymology. 19: 406-421. DOI: 10.1016/0076-6879(70)19030-6  0.8
1965 Tang J. Competitive inhibition of pepsin by aliphatic alcohols Journal of Biological Chemistry. 240: 3810-3815. PMID 5320642  0.8
1963 Tang J. Specificity of pepsin and its dependence on a possible 'hydrophobic binding site' [16] Nature. 199: 1094-1095. PMID 14066947 DOI: 10.1038/1991094a0  0.8
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