| Year |
Citation |
Score |
| 2019 |
Wong L, Narla RK, Leisten J, Bauer D, Groza M, Gaffney B, Havens CG, Choi J, Houston J, Lopez-Girona A, Hansen J, Cathers BE, Carmichael J, Pierce DW. CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma Blood. 134: 1815-1815. DOI: 10.1182/blood-2019-124345 |
0.37 |
|
| 2019 |
Lopez-Girona A, Havens CG, Lu G, Rychak E, Mendy D, Gaffney B, Surka C, Lu C, Matyskiela M, Khambatta G, Wong L, Hansen J, Pierce DW, Cathers BE, Carmichael J. CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells Blood. 134: 1812-1812. DOI: 10.1182/blood-2019-124338 |
0.423 |
|
| 2015 |
Bjorklund CC, Lu L, Kang J, Hagner PR, Havens CG, Amatangelo M, Wang M, Ren Y, Couto S, Breider M, Ning Y, Gandhi AK, Daniel TO, Chopra R, Klippel A, et al. Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood Cancer Journal. 5: e354. PMID 26430725 DOI: 10.1038/Bcj.2015.66 |
0.404 |
|
| 2015 |
Hagner PR, Man HW, Fontanillo C, Wang M, Couto S, Breider M, Bjorklund C, Havens CG, Lu G, Rychak E, Raymon H, Narla RK, Barnes L, Khambatta G, Chiu H, et al. CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL. Blood. PMID 26002965 DOI: 10.1182/Blood-2015-02-628669 |
0.423 |
|
| 2014 |
Gandhi AK, Kang J, Havens CG, Conklin T, Ning Y, Wu L, Ito T, Ando H, Waldman MF, Thakurta A, Klippel A, Handa H, Daniel TO, Schafer PH, Chopra R. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). British Journal of Haematology. 164: 811-21. PMID 24328678 DOI: 10.1111/Bjh.12708 |
0.316 |
|
| 2014 |
Bjorklund CC, Havens CG, Hagner PR, Gandhi AK, Wang M, Amatangelo MD, Lu L, Wang H, Breider M, Ren Y, Lopez-Girona A, Thakurta A, Klippel A, Chopra R. Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds Blood. 124: 4700-4700. DOI: 10.1182/Blood.V124.21.4700.4700 |
0.422 |
|
| 2014 |
Havens CG, Bjorklund C, Kang J, Ortiz M, Fontanillo C, Amatangelo M, Lu L, Neri PE, Lopez-Girona A, Bahlis NJ, Thakurta A, Trotter M, Gandhi AK, Klippel A, Chopra R. IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance Blood. 124: 3432-3432. DOI: 10.1182/BLOOD.V124.21.3432.3432 |
0.325 |
|
| 2014 |
Hagner P, Wang M, Couto S, Breider M, Fontanillo C, Trotter M, Bjorklund CC, Havens CG, Raymon HK, Narla RK, Barnes L, Waldman M, Daniel T, Klippel A, Pourdehnad M, et al. CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways Blood. 124: 3035-3035. DOI: 10.1182/Blood.V124.21.3035.3035 |
0.373 |
|
| 2012 |
Salguero I, Guarino E, Shepherd ME, Deegan TD, Havens CG, MacNeill SA, Walter JC, Kearsey SE. Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Current Biology : Cb. 22: 720-6. PMID 22464192 DOI: 10.1016/J.Cub.2012.02.070 |
0.386 |
|
| 2012 |
Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC. Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. The Journal of Biological Chemistry. 287: 11410-21. PMID 22303007 DOI: 10.1074/Jbc.M111.337683 |
0.326 |
|
| 2011 |
Havens CG, Walter JC. Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes & Development. 25: 1568-82. PMID 21828267 DOI: 10.1101/Gad.2068611 |
0.388 |
|
| 2010 |
Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Molecular Cell. 40: 22-33. PMID 20932472 DOI: 10.1016/J.Molcel.2010.09.015 |
0.368 |
|
| 2000 |
Havens CG, Bryant N, Asher L, Lamoreaux L, Perfetto S, Brendle JJ, Werbovetz KA. Cellular effects of leishmanial tubulin inhibitors on L. donovani Molecular and Biochemical Parasitology. 110: 223-236. PMID 11071278 DOI: 10.1016/S0166-6851(00)00272-3 |
0.367 |
|
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