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Kim L.R. Brouwer - Publications

Affiliations: 
1986- Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmaceutical Chemistry
Website:
https://pharmacy.unc.edu/news/directory/kbrouwer/

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yang F, Medik Y, Li L, Tian X, Fu D, Brouwer KLR, Wagner K, Sun B, Sendi H, Mi Y, Wang AZ. Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo. Small (Weinheim An Der Bergstrasse, Germany). e1906360. PMID 31972070 DOI: 10.1002/smll.201906360  0.6
2019 Ito K, Sjostedt N, Brouwer KLR. Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31744810 DOI: 10.1124/dmd.119.088898  0.32
2019 Bezencon J, Beaudoin JJ, Ito K, Fu D, Roth SE, Brock WJ, Brouwer KL. Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31160314 DOI: 10.1124/dmd.119.086785  0.32
2019 Malinen MM, Ito K, Kang HE, Honkakoski P, Brouwer KLR. Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 30685239 DOI: 10.1016/j.ejps.2019.01.022  0.32
2019 Ali I, Khalid S, Stieger B, Brouwer KLR. Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications. Molecular Pharmaceutics. PMID 30608704 DOI: 10.1021/acs.molpharmaceut.8b01124  0.36
2018 Kenna JG, Taskar KS, Battista C, Bourdet DL, Brouwer KLR, Brouwer KR, Dai D, Funk C, Hafey MJ, Lai Y, Maher J, Anne Pak Y, Pedersen JM, Polli JW, David Rodrigues A, et al. Can BSEP Inhibition Testing In Drug Discovery And Development Reduce Liver Injury Risk? - An International Transporter Consortium Perspective. Clinical Pharmacology and Therapeutics. PMID 30137645 DOI: 10.1002/cpt.1222  0.4
2018 Evers R, Piquette-Miller M, Polli JW, Russel FGM, Sprowl JA, Tohyama K, Ware JA, de Wildt SN, Xie W, Brouwer KLR. Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper from the International Transporter Consortium. Clinical Pharmacology and Therapeutics. PMID 29756222 DOI: 10.1002/cpt.1115  0.4
2016 Lu Y, Slizgi JR, Brouwer KR, Claire RL, Freeman KM, Pan M, Brock WJ, Brouwer KL. Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27013400 DOI: 10.1124/dmd.115.067629  0.48
2016 Yang K, Guo C, Woodhead JL, St Claire RL, Watkins PB, Siler SQ, Howell BA, Brouwer KL. Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. Journal of Pharmaceutical Sciences. 105: 443-59. PMID 26869411 DOI: 10.1016/j.xphs.2015.11.008  0.88
2015 Slizgi JR, Lu Y, Brouwer KR, St Claire RL, Freeman KM, Pan M, Brock WJ, Brouwer KL. Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury? Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26507107 DOI: 10.1093/toxsci/kfv231  0.48
2015 Ferslew BC, Xie G, Johnston CK, Su M, Stewart PW, Jia W, Brouwer KL, Sidney Barritt A. Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis. Digestive Diseases and Sciences. PMID 26138654 DOI: 10.1007/s10620-015-3776-8  0.88
2015 Watt KM, Gonzalez D, Benjamin DK, Brouwer KL, Wade KC, Capparelli E, Barrett J, Cohen-Wolkowiez M. Fluconazole Population Pharmacokinetics and Dosing for Prevention and Treatment of Invasive Candidiasis in Children Supported with Extracorporeal Membrane Oxygenation. Antimicrobial Agents and Chemotherapy. 59: 3935-43. PMID 25896706 DOI: 10.1128/AAC.00102-15  0.88
2015 Welch MA, Köck K, Urban TJ, Brouwer KL, Swaan PW. Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 725-34. PMID 25735837 DOI: 10.1124/dmd.114.062539  0.88
2015 Yang K, Pfeifer ND, Köck K, Brouwer KL. Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury. The Journal of Pharmacology and Experimental Therapeutics. 353: 415-23. PMID 25711339 DOI: 10.1124/jpet.114.221564  0.88
2014 Powell J, Farasyn T, Köck K, Meng X, Pahwa S, Brouwer KL, Yue W. Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1964-70. PMID 25200870 DOI: 10.1124/dmd.114.056945  0.88
2014 Lauffenburger JC, Mayer CL, Hawke RL, Brouwer KL, Fried MW, Farley JF. Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential. European Journal of Gastroenterology & Hepatology. 26: 1073-82. PMID 25014625 DOI: 10.1097/MEG.0000000000000152  0.88
2014 Ferslew BC, Köck K, Bridges AS, Brouwer KL. Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1567-74. PMID 24958844 DOI: 10.1124/dmd.114.057554  0.88
2014 Yang K, Pfeifer ND, Hardwick RN, Yue W, Stewart PW, Brouwer KL. An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown. Molecular Pharmaceutics. 11: 766-75. PMID 24410402 DOI: 10.1021/mp400471e  0.88
2014 Pfeifer ND, Hardwick RN, Brouwer KL. Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics. Annual Review of Pharmacology and Toxicology. 54: 509-35. PMID 24160696 DOI: 10.1146/annurev-pharmtox-011613-140021  0.88
2014 Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL. Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 665-74. PMID 24154606 DOI: 10.1124/dmd.113.054304  0.88
2013 Pfeifer ND, Bridges AS, Ferslew BC, Hardwick RN, Brouwer KL. Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver. The Journal of Pharmacology and Experimental Therapeutics. 347: 737-45. PMID 24080682 DOI: 10.1124/jpet.113.208314  0.88
2013 Pfeifer ND, Yang K, Brouwer KL. Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 347: 727-36. PMID 24023367 DOI: 10.1124/jpet.113.207472  0.88
2013 Pfeifer ND, Harris KB, Yan GZ, Brouwer KL. Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1949-56. PMID 23990525 DOI: 10.1124/dmd.113.052134  0.88
2013 McNeely EB, Talameh JA, Adams KF, Hull JH, Simmons B, Henry J, Brouwer KL, Patterson JH. Relative bioavailability of tolvaptan administered via nasogastric tube and tolvaptan tablets swallowed intact. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 70: 1230-7. PMID 23820460 DOI: 10.2146/ajhp120543  0.88
2013 Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR. Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Molecular Pharmacology. 84: 182-9. PMID 23680637 DOI: 10.1124/mol.112.084517  0.88
2013 Yang K, Köck K, Sedykh A, Tropsha A, Brouwer KL. An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters. Journal of Pharmaceutical Sciences. 102: 3037-57. PMID 23653385 DOI: 10.1002/jps.23584  0.88
2013 Swift B, Nebot N, Lee JK, Han T, Proctor WR, Thakker DR, Lang D, Radtke M, Gnoth MJ, Brouwer KL. Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1179-86. PMID 23482500 DOI: 10.1124/dmd.112.048181  0.88
2013 Köck K, Xie Y, Hawke RL, Oberlies NH, Brouwer KL. Interaction of silymarin flavonolignans with organic anion-transporting polypeptides. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 958-65. PMID 23401473 DOI: 10.1124/dmd.112.048272  0.88
2013 Griffin LM, Watkins PB, Perry CH, St Claire RL, Brouwer KL. Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 188-96. PMID 23091188 DOI: 10.1124/dmd.112.047225  0.6
2012 Watt KM, Benjamin DK, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli EV, Cohen-Wolkowiez M. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. The Pediatric Infectious Disease Journal. 31: 1042-7. PMID 22627870 DOI: 10.1097/INF.0b013e31825d3091  0.88
2012 Joy MS, La M, Wang J, Bridges AS, Hu Y, Hogan SL, Frye RF, Blaisdell J, Goldstein JA, Dooley MA, Brouwer KL, Falk RJ. Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. British Journal of Clinical Pharmacology. 74: 445-55. PMID 22380717 DOI: 10.1111/j.1365-2125.2012.04223.x  0.88
2012 Marion TL, Perry CH, St Claire RL, Brouwer KL. Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. Toxicology and Applied Pharmacology. 261: 1-9. PMID 22342602 DOI: 10.1016/j.taap.2012.02.002  0.88
2012 Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF. A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 6-17. PMID 21953913 DOI: 10.1124/dmd.111.040063  0.88
2011 Yan GZ, Brouwer KL, Pollack GM, Wang MZ, Tidwell RR, Hall JE, Paine MF. Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. The Journal of Pharmacology and Experimental Therapeutics. 337: 503-12. PMID 21320872 DOI: 10.1124/jpet.110.177220  0.88
2011 Marion TL, Perry CH, St Claire RL, Yue W, Brouwer KL. Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 371-80. PMID 21262925 DOI: 10.1093/toxsci/kfr014  0.88
2011 Yue W, Lee JK, Abe K, Sugiyama Y, Brouwer KL. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 441-7. PMID 21106720 DOI: 10.1124/dmd.110.035188  0.44
2010 Swift B, Yue W, Brouwer KL. Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes. Pharmaceutical Research. 27: 1987-98. PMID 20652625 DOI: 10.1007/s11095-010-0203-x  0.44
2010 Yanni SB, Augustijns PF, Benjamin DK, Brouwer KL, Thakker DR, Annaert PP. In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1848-56. PMID 20606004 DOI: 10.1124/dmd.110.033811  0.88
2010 Lee JK, Paine MF, Brouwer KL. Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 334: 410-8. PMID 20430841 DOI: 10.1124/jpet.110.165852  0.36
2010 Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, et al. Membrane transporters in drug development. Nature Reviews. Drug Discovery. 9: 215-36. PMID 20190787 DOI: 10.1038/nrd3028  0.88
2010 Swift B, Pfeifer ND, Brouwer KL. Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metabolism Reviews. 42: 446-71. PMID 20109035 DOI: 10.3109/03602530903491881  0.88
2010 McRae M, Rezk NL, Bridges AS, Corbett AH, Tien HC, Brouwer KL, Kashuba AD. Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity. Pharmacotherapy. 30: 17-24. PMID 20030469 DOI: 10.1592/phco.30.1.17  0.88
2010 Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation. The Journal of Pharmacology and Experimental Therapeutics. 332: 26-34. PMID 19801447 DOI: 10.1124/jpet.109.156653  0.88
2010 Wolf KK, Vora S, Webster LO, Generaux GT, Polli JW, Brouwer KL. Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 297-309. PMID 19706322 DOI: 10.1016/j.tiv.2009.08.009  0.48
2009 Swift B, Tian X, Brouwer KL. Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function. Pharmaceutical Research. 26: 1942-51. PMID 19495943 DOI: 10.1007/s11095-009-9909-z  0.6
2009 Lee JK, Abe K, Bridges AS, Patel NJ, Raub TJ, Pollack GM, Brouwer KL. Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1916-21. PMID 19487254 DOI: 10.1124/dmd.109.026815  0.88
2009 Yue W, Abe K, Brouwer KL. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Molecular Pharmaceutics. 6: 134-43. PMID 19105722 DOI: 10.1021/mp800100e  0.44
2009 Abe K, Bridges AS, Brouwer KL. Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 447-52. PMID 19074974 DOI: 10.1124/dmd.108.023465  0.6
2009 Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, Brouwer KL. Relationship between drug/metabolite exposure and impairment of excretory transport function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 386-90. PMID 19022942 DOI: 10.1124/dmd.108.023648  0.88
2008 Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Brouwer KL. Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2156-8. PMID 18719241 DOI: 10.1124/dmd.108.022053  0.88
2008 Miranda SR, Lee JK, Brouwer KL, Wen Z, Smith PC, Hawke RL. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2219-26. PMID 18687803 DOI: 10.1124/dmd.108.021790  0.36
2008 Wolf KK, Brouwer KR, Pollack GM, Brouwer KL. Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2086-92. PMID 18653747 DOI: 10.1124/dmd.108.020842  0.48
2008 Abe K, Bridges AS, Yue W, Brouwer KL. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance. The Journal of Pharmacology and Experimental Therapeutics. 326: 983-90. PMID 18574002 DOI: 10.1124/jpet.108.138073  0.6
2008 Ghibellini G, Leslie EM, Pollack GM, Brouwer KL. Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharmaceutical Research. 25: 1851-60. PMID 18509604 DOI: 10.1007/s11095-008-9597-0  0.88
2008 Tian X, Swift B, Zamek-Gliszczynski MJ, Belinsky MG, Kruh GD, Brouwer KL. Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 911-5. PMID 18276836 DOI: 10.1124/dmd.107.019273  0.88
2008 Lee JK, Leslie EM, Zamek-Gliszczynski MJ, Brouwer KL. Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity. Toxicology and Applied Pharmacology. 228: 17-23. PMID 18191164 DOI: 10.1016/j.taap.2007.11.020  0.88
2008 Bow DA, Perry JL, Miller DS, Pritchard JB, Brouwer KL. Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 198-202. PMID 17954525 DOI: 10.1124/dmd.107.018200  0.88
2008 Tian X, Zamek-Gliszczynski MJ, Li J, Bridges AS, Nezasa K, Patel NJ, Raub TJ, Brouwer KL. Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 61-4. PMID 17913796 DOI: 10.1124/dmd.107.017319  0.88
2007 Marion TL, Leslie EM, Brouwer KL. Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Molecular Pharmaceutics. 4: 911-8. PMID 17963355 DOI: 10.1021/mp0700357  0.88
2007 Leslie EM, Ghibellini G, Nezasa K, Brouwer KL. Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats. Carcinogenesis. 28: 2650-6. PMID 17724374 DOI: 10.1093/carcin/bgm187  0.88
2007 Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice. Antimicrobial Agents and Chemotherapy. 51: 3230-4. PMID 17576841 DOI: 10.1128/AAC.00082-07  0.88
2007 Leslie EM, Watkins PB, Kim RB, Brouwer KL. Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 321: 1170-8. PMID 17374746 DOI: 10.1124/jpet.106.119073  0.64
2007 Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW, Gan LS. Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 835-40. PMID 17332143 DOI: 10.1124/dmd.106.013946  0.88
2007 Ghibellini G, Bridges AS, Generaux CN, Brouwer KL. In vitro and in vivo determination of piperacillin metabolism in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 345-9. PMID 17194717 DOI: 10.1124/dmd.106.012278  0.88
2006 Zamek-Gliszczynski MJ, Nezasa K, Tian X, Bridges AS, Lee K, Belinsky MG, Kruh GD, Brouwer KL. Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 1485-91. PMID 16988054 DOI: 10.1124/jpet.106.110106  0.88
2006 Zamek-Gliszczynski MJ, Nezasa K, Tian X, Kalvass JC, Patel NJ, Raub TJ, Brouwer KL. The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice. Molecular Pharmacology. 70: 2127-33. PMID 16959944 DOI: 10.1124/mol.106.026955  0.88
2006 Ghibellini G, Vasist LS, Hill TE, Heizer WD, Kowalsky RJ, Brouwer KL. Determination of the biliary excretion of piperacillin in humans using a novel method. British Journal of Clinical Pharmacology. 62: 304-8. PMID 16934046 DOI: 10.1111/j.1365-2125.2006.02662.x  0.88
2006 Zamek-Gliszczynski MJ, Hoffmaster KA, Humphreys JE, Tian X, Nezasa K, Brouwer KL. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. The Journal of Pharmacology and Experimental Therapeutics. 319: 459-67. PMID 16857726 DOI: 10.1124/jpet.106.101840  0.88
2006 Ghibellini G, Leslie EM, Brouwer KL. Methods to evaluate biliary excretion of drugs in humans: an updated review. Molecular Pharmaceutics. 3: 198-211. PMID 16749853 DOI: 10.1021/mp060011k  0.88
2006 McRae MP, Lowe CM, Tian X, Bourdet DL, Ho RH, Leake BF, Kim RB, Brouwer KL, Kashuba AD. Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 318: 1068-75. PMID 16720753 DOI: 10.1124/jpet.106.102657  0.88
2006 Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL. Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 318: 881-9. PMID 16690724 DOI: 10.1124/jpet.106.102616  0.88
2006 Turncliff RZ, Tian X, Brouwer KL. Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes. Biochemical Pharmacology. 71: 1520-9. PMID 16542640 DOI: 10.1016/j.bcp.2006.02.004  0.88
2006 Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 27: 447-86. PMID 16472997 DOI: 10.1016/j.ejps.2005.12.007  0.88
2006 Nezasa K, Tian X, Zamek-Gliszczynski MJ, Patel NJ, Raub TJ, Brouwer KL. Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 718-23. PMID 16434545 DOI: 10.1124/dmd.105.007922  0.88
2006 Johnson BM, Zhang P, Schuetz JD, Brouwer KL. Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 556-62. PMID 16204465 DOI: 10.1124/dmd.105.005793  0.88
2005 Tian X, Zhang P, Zamek-Gliszczynski MJ, Brouwer KL. Knocking down transport: applications of RNA interference in the study of drug transport proteins. Drug Metabolism Reviews. 37: 705-23. PMID 16393889 DOI: 10.1080/03602530500364098  0.88
2005 Chandra P, Johnson BM, Zhang P, Pollack GM, Brouwer KL. Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1238-43. PMID 15908472 DOI: 10.1124/dmd.105.003665  0.88
2005 Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC, Brouwer KL. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1158-65. PMID 15860656 DOI: 10.1124/dmd.104.002188  0.88
2005 Zhang P, Tian X, Chandra P, Brouwer KL. Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes. Molecular Pharmacology. 67: 1334-41. PMID 15662046 DOI: 10.1124/mol.104.004481  0.88
2005 Chandra P, Zhang P, Brouwer KL. Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G1252-8. PMID 15650133 DOI: 10.1152/ajpgi.00362.2004  0.88
2005 Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 287-93. PMID 15528320 DOI: 10.1124/dmd.104.001420  0.88
2005 Kemp DC, Zamek-Gliszczynski MJ, Brouwer KL. Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 207-14. PMID 15509663 DOI: 10.1093/toxsci/kfi020  0.88
2004 Ghibellini G, Johnson BM, Kowalsky RJ, Heizer WD, Brouwer KL. A novel method for the determination of biliary clearance in humans. The Aaps Journal. 6: e33. PMID 15760098 DOI: 10.1208/aapsj060433  0.88
2004 Kemp DC, Brouwer KL. Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. Toxicology in Vitro : An International Journal Published in Association With Bibra. 18: 869-77. PMID 15465654 DOI: 10.1016/j.tiv.2004.04.014  0.6
2004 Tian X, Zamek-Gliszczynski MJ, Zhang P, Brouwer KL. Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes. Molecular Pharmacology. 66: 1004-10. PMID 15385645 DOI: 10.1124/mol.66.4.  0.88
2004 Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems. The Journal of Pharmacology and Experimental Therapeutics. 311: 1203-10. PMID 15302892 DOI: 10.1124/jpet.104.070201  0.88
2004 Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharmaceutical Research. 21: 1294-302. PMID 15290872 DOI: 10.1023/B:PHAM.0000033018.97745.0d  0.88
2004 Turncliff RZ, Meier PJ, Brouwer KL. Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 834-9. PMID 15258109 DOI: 10.1124/dmd.32.8.834  0.88
2004 Chandra P, Brouwer KL. The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharmaceutical Research. 21: 719-35. PMID 15180326  0.88
2004 Persky AM, Berry NS, Pollack GM, Brouwer KL. Modelling the cardiovascular effects of ephedrine. British Journal of Clinical Pharmacology. 57: 552-62. PMID 15089807 DOI: 10.1111/j.1365-2125.2003.02062.x  0.88
2003 Patel NJ, Zamek-Gliszczynski MJ, Zhang P, Han YH, Jansen PL, Meier PJ, Stieger B, Brouwer KL. Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions. Molecular Pharmacology. 64: 154-9. PMID 12815171 DOI: 10.1124/mol.64.1.154  0.88
2003 McRae MP, Brouwer KL, Kashuba AD. Cytokine regulation of P-glycoprotein. Drug Metabolism Reviews. 35: 19-33. PMID 12635814 DOI: 10.1081/DMR-120018247  0.88
2003 Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL. Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver. The Journal of Pharmacology and Experimental Therapeutics. 304: 801-9. PMID 12538836 DOI: 10.1124/jpet.102.044107  0.88
2002 Brouwer KL, Pollack GM. Pharmacogenetics: is the right drug for the right patient sufficient? Advanced Drug Delivery Reviews. 54: 1243-4. PMID 12406642 DOI: 10.1016/S0169-409X(02)00164-3  0.88
2002 Lee K, Ng C, Brouwer KL, Thakker DR. Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 303: 574-80. PMID 12388638 DOI: 10.1124/jpet.102.038521  0.88
2002 Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM, Brouwer KL. Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 962-9. PMID 12167560 DOI: 10.1124/dmd.30.9.962  0.88
2002 Xiong H, Yoshinari K, Brouwer KL, Negishi M. Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 918-23. PMID 12124310  0.52
2002 Murthy BR, Pollack GM, Brouwer KL. Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers. Journal of Clinical Pharmacology. 42: 569-76. PMID 12017351 DOI: 10.1177/00912700222011508  0.88
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