| Year |
Citation |
Score |
| 2016 |
Krappmann M, de Boer AR, Kool DR, Irth H, Letzel T. Mass spectrometric real-time monitoring of an enzymatic phosphorylation assay using internal standards and data-handling freeware. Rapid Communications in Mass Spectrometry : Rcm. 30: 1019-30. PMID 27003039 DOI: 10.1002/Rcm.7529 |
0.383 |
|
| 2012 |
Falck D, de Vlieger JS, Giera M, Honing M, Irth H, Niessen WM, Kool J. On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors. Analytical and Bioanalytical Chemistry. 403: 367-75. PMID 22227812 DOI: 10.1007/S00216-011-5663-2 |
0.374 |
|
| 2011 |
Kool J, Heus F, de Kloe G, Lingeman H, Smit AB, Leurs R, Edink E, De Esch IJ, Irth H, Niessen WM. High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology. Journal of Biomolecular Screening. 16: 917-24. PMID 21799121 DOI: 10.1177/1087057111413921 |
0.368 |
|
| 2011 |
Kool J, Jonker N, Irth H, Niessen WM. Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods. Analytical and Bioanalytical Chemistry. 401: 1109-25. PMID 21755271 DOI: 10.1007/S00216-011-5207-9 |
0.348 |
|
| 2011 |
de Vlieger JS, Giezen MJ, Falck D, Tump C, van Heuveln F, Giera M, Kool J, Lingeman H, Wieling J, Honing M, Irth H, Niessen WM. High temperature liquid chromatography hyphenated with ESI-MS and ICP-MS detection for the structural characterization and quantification of halogen containing drug metabolites. Analytica Chimica Acta. 698: 69-76. PMID 21645661 DOI: 10.1016/J.Aca.2011.04.053 |
0.392 |
|
| 2011 |
Martha CT, Hoogendoorn JC, Irth H, Niessen WM. Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches. Talanta. 84: 623-31. PMID 21482259 DOI: 10.1016/J.Talanta.2011.01.051 |
0.408 |
|
| 2011 |
Marques LA, Maada I, de Kanter FJ, Lingeman H, Irth H, Niessen WM, Giera M. Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide. Journal of Pharmaceutical and Biomedical Analysis. 55: 85-92. PMID 21300511 DOI: 10.1016/J.Jpba.2011.01.022 |
0.32 |
|
| 2011 |
Kretschmer A, Giera M, Wijtmans M, de Vries L, Lingeman H, Irth H, Niessen WM. Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 879: 1393-401. PMID 21176889 DOI: 10.1016/J.Jchromb.2010.11.028 |
0.399 |
|
| 2011 |
Kool J, de Kloe G, Denker AD, van Altena K, Smoluch M, van Iperen D, Nahar TT, Limburg RJ, Niessen WM, Lingeman H, Leurs R, de Esch IJ, Smit AB, Irth H. Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis. Analytical Chemistry. 83: 125-32. PMID 21117623 DOI: 10.1021/Ac102001G |
0.438 |
|
| 2011 |
Kool J, Giera M, Irth H, Niessen WM. Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures. Analytical and Bioanalytical Chemistry. 399: 2655-68. PMID 21107824 DOI: 10.1007/S00216-010-4406-0 |
0.408 |
|
| 2011 |
Jonker N, Kool J, Irth H, Niessen WM. Recent developments in protein-ligand affinity mass spectrometry. Analytical and Bioanalytical Chemistry. 399: 2669-81. PMID 21058031 DOI: 10.1007/S00216-010-4350-Z |
0.363 |
|
| 2011 |
De Kloe GE, Kool J, Van Elk R, Van Muijlwijk-Koezen JE, Smit AB, Lingeman H, Irth H, Niessen WMA, De Esch IJP. Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors Medchemcomm. 2: 590-595. DOI: 10.1039/C1Md00031D |
0.325 |
|
| 2010 |
Martha CT, van Zeist WJ, Bickelhaupt FM, Irth H, Niessen WM. Tandem mass spectrometry of silver-adducted ferrocenyl catalyst complexes. Journal of Mass Spectrometry : Jms. 45: 1332-43. PMID 20967738 DOI: 10.1002/Jms.1846 |
0.303 |
|
| 2010 |
Heus F, Giera M, de Kloe GE, van Iperen D, Buijs J, Nahar TT, Smit AB, Lingeman H, de Esch IJ, Niessen WM, Irth H, Kool J. Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays. Analytical and Bioanalytical Chemistry. 398: 3023-32. PMID 20872136 DOI: 10.1007/S00216-010-4210-X |
0.459 |
|
| 2010 |
de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ. Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands. Journal of Medicinal Chemistry. 53: 7192-201. PMID 20828128 DOI: 10.1021/Jm100834Y |
0.33 |
|
| 2010 |
Falck D, de Vlieger JS, Niessen WM, Kool J, Honing M, Giera M, Irth H. Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS. Analytical and Bioanalytical Chemistry. 398: 1771-80. PMID 20730527 DOI: 10.1007/S00216-010-4087-8 |
0.441 |
|
| 2010 |
Jonker N, Lingeman H, Irth H. Direct Dynamic Protein-Affinity Selection Mass-Spectrometry. Chromatographia. 72: 7-13. PMID 20628447 DOI: 10.1365/S10337-010-1586-X |
0.428 |
|
| 2010 |
Retra K, Geitmann M, Kool J, Smit AB, de Esch IJ, Danielson UH, Irth H. Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands. Analytical Biochemistry. 407: 58-64. PMID 20599657 DOI: 10.1016/J.Ab.2010.06.021 |
0.364 |
|
| 2010 |
Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H. Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification. Journal of Medicinal Chemistry. 53: 4720-30. PMID 20518527 DOI: 10.1021/Jm100230K |
0.384 |
|
| 2010 |
Marques LA, Kool J, de Kanter F, Lingeman H, Niessen W, Irth H. Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine. Journal of Pharmaceutical and Biomedical Analysis. 53: 609-16. PMID 20466502 DOI: 10.1016/J.Jpba.2010.04.015 |
0.336 |
|
| 2010 |
Kool J, Lingeman H, Niessen W, Irth H. High throughput screening methodologies classified for major drug target classes according to target signaling pathways. Combinatorial Chemistry & High Throughput Screening. 13: 548-61. PMID 20429869 DOI: 10.2174/138620710791515815 |
0.311 |
|
| 2010 |
Giera M, de Vlieger JS, Lingeman H, Irth H, Niessen WM. Structural elucidation of biologically active neomycin N-octyl derivatives in a regioisomeric mixture by means of liquid chromatography/ion trap time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 24: 1439-46. PMID 20411583 DOI: 10.1002/Rcm.4534 |
0.441 |
|
| 2010 |
Eggink M, Wijtmans M, Kretschmer A, Kool J, Lingeman H, de Esch IJ, Niessen WM, Irth H. Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA. Analytical and Bioanalytical Chemistry. 397: 665-75. PMID 20238107 DOI: 10.1007/S00216-010-3575-1 |
0.391 |
|
| 2010 |
de Vlieger JS, Kolkman AJ, Ampt KA, Commandeur JN, Vermeulen NP, Kool J, Wijmenga SS, Niessen WM, Irth H, Honing M. Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 667-74. PMID 20149764 DOI: 10.1016/J.Jchromb.2010.01.035 |
0.44 |
|
| 2010 |
León Z, de Vlieger J, Chisvert A, Salvador A, Lingeman H, Irth H, Giera M. Identification of the Biotransformation Products of 2-Ethylhexyl 4-(N,N-Dimethylamino)benzoate. Chromatographia. 71: 55-63. PMID 20062819 DOI: 10.1365/S10337-009-1386-3 |
0.389 |
|
| 2010 |
Retra K, Irth H, Van Muijlwijk-Koezen JE. Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD Drug Discovery Today: Technologies. 7: e181-e187. DOI: 10.1016/J.Ddtec.2010.11.012 |
0.312 |
|
| 2009 |
Eggink M, Charret S, Wijtmans M, Lingeman H, Kool J, Niessen WM, Irth H. Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 3937-45. PMID 19880357 DOI: 10.1016/J.Jchromb.2009.09.043 |
0.469 |
|
| 2009 |
Martha CT, Heemskerk A, Hoogendoorn JC, Elders N, Niessen WM, Orru RV, Irth H. High-throughput reaction optimisation and activity screening of ferrocene-based Lewis acid-catalyst complexes by using continuous-flow reaction detection mass spectrometry. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 7368-75. PMID 19551778 DOI: 10.1002/Chem.200900317 |
0.348 |
|
| 2009 |
Giera M, Heus F, Janssen L, Kool J, Lingeman H, Irth H. Microfractionation revisited: a 1536 well high resolution screening assay. Analytical Chemistry. 81: 5460-6. PMID 19507859 DOI: 10.1021/Ac900622B |
0.447 |
|
| 2009 |
Jonker N, Kretschmer A, Kool J, Fernandez A, Kloos D, Krabbe JG, Lingeman H, Irth H. Online magnetic bead dynamic protein-affinity selection coupled to LC-MS for the screening of pharmacologically active compounds. Analytical Chemistry. 81: 4263-70. PMID 19476387 DOI: 10.1021/Ac9000755 |
0.434 |
|
| 2009 |
Schebb NH, Faber H, Maul R, Heus F, Kool J, Irth H, Karst U. Analysis of glutathione adducts of patulin by means of liquid chromatography (HPLC) with biochemical detection (BCD) and electrospray ionization tandem mass spectrometry (ESI-MS/MS). Analytical and Bioanalytical Chemistry. 394: 1361-73. PMID 19390846 DOI: 10.1007/S00216-009-2765-1 |
0.454 |
|
| 2008 |
Eggink M, Wijtmans M, Ekkebus R, Lingeman H, de Esch IJ, Kool J, Niessen WM, Irth H. Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures. Analytical Chemistry. 80: 9042-51. PMID 19551932 DOI: 10.1021/Ac801429W |
0.41 |
|
| 2008 |
Jonker N, Kool J, Krabbe JG, Retra K, Lingeman H, Irth H. Screening of protein-ligand interactions using dynamic protein-affinity chromatography solid-phase extraction-liquid chromatography-mass spectrometry. Journal of Chromatography. A. 1205: 71-7. PMID 18715568 DOI: 10.1016/J.Chroma.2008.07.089 |
0.463 |
|
| 2008 |
Martha CT, Elders N, Krabbe JG, Kool J, Niessen WM, Orru RV, Irth H. Online screening of homogeneous catalyst performance using reaction detection mass spectrometry. Analytical Chemistry. 80: 7121-7. PMID 18698801 DOI: 10.1021/Ac801003H |
0.369 |
|
| 2008 |
Schebb NH, Heus F, Saenger T, Karst U, Irth H, Kool J. Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors. Analytical Chemistry. 80: 6764-72. PMID 18686973 DOI: 10.1021/Ac801035E |
0.447 |
|
| 2008 |
Marchesini GR, Meimaridou A, Haasnoot W, Meulenberg E, Albertus F, Mizuguchi M, Takeuchi M, Irth H, Murk AJ. Biosensor discovery of thyroxine transport disrupting chemicals. Toxicology and Applied Pharmacology. 232: 150-60. PMID 18647617 DOI: 10.1016/J.Taap.2008.06.014 |
0.336 |
|
| 2008 |
Carol-Visser J, van der Schans M, Fidder A, Hulst AG, van Baar BL, Irth H, Noort D. Development of an automated on-line pepsin digestion-liquid chromatography-tandem mass spectrometry configuration for the rapid analysis of protein adducts of chemical warfare agents. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 870: 91-7. PMID 18573700 DOI: 10.1016/J.Jchromb.2008.06.008 |
0.424 |
|
| 2008 |
Eggink M, Romero W, Vreuls RJ, Lingeman H, Niessen WM, Irth H. Development and optimization of a system for comprehensive two-dimensional liquid chromatography with UV and mass spectrometric detection for the separation of complex samples by multi-step gradient elution. Journal of Chromatography. A. 1188: 216-26. PMID 18339395 DOI: 10.1016/J.Chroma.2008.02.072 |
0.482 |
|
| 2008 |
Akoto L, Stellaard F, Irth H, Vreuls RJ, Pel R. Improved fatty acid detection in micro-algae and aquatic meiofauna species using a direct thermal desorption interface combined with comprehensive gas chromatography-time-of-flight mass spectrometry. Journal of Chromatography. A. 1186: 254-61. PMID 18295771 DOI: 10.1016/J.Chroma.2008.02.005 |
0.372 |
|
| 2008 |
Akoto L, Vreuls RJ, Irth H, Floris V, Hoogveld H, Pel R. Determination of the carbon isotopic composition of whole/intact biological specimens using at-line direct thermal desorption to effect thermally assisted hydrolysis/methylation. Journal of Chromatography. A. 1186: 372-9. PMID 17897655 DOI: 10.1016/J.Chroma.2007.08.082 |
0.319 |
|
| 2008 |
Akoto L, Vreuls RJ, Irth H, Pel R, Stellaard F. Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatography-mass spectrometry. Journal of Chromatography. A. 1186: 365-71. PMID 17889883 DOI: 10.1016/J.Chroma.2007.08.080 |
0.318 |
|
| 2007 |
Kool J, van Marle A, Hulscher S, Selman M, van Iperen DJ, van Altena K, Gillard M, Bakker RA, Irth H, Leurs R, Vermeulen NP. A flow-through fluorescence polarization detection system for measuring GPCR-mediated modulation of cAMP production. Journal of Biomolecular Screening. 12: 1074-83. PMID 18087072 DOI: 10.1177/1087057107308881 |
0.373 |
|
| 2007 |
Van Liempd SM, Kool J, Meerman JH, Irth H, Vermeulen NP. Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening. Chemical Research in Toxicology. 20: 1825-32. PMID 17975887 DOI: 10.1021/Tx7000724 |
0.455 |
|
| 2007 |
Hoos JS, Damsten MC, de Vlieger JS, Commandeur JN, Vermeulen NP, Niessen WM, Lingeman H, Irth H. Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 859: 147-56. PMID 17913598 DOI: 10.1016/J.Jchromb.2007.09.015 |
0.493 |
|
| 2007 |
Kool J, van Liempd SM, Harmsen S, Beckman J, van Elswijk D, Commandeur JN, Irth H, Vermeulen NP. Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 858: 49-58. PMID 17826363 DOI: 10.1016/J.Jchromb.2007.08.005 |
0.436 |
|
| 2007 |
Kool J, Van Liempd SM, Harmsen S, Schenk T, Irth H, Commandeur JN, Vermeulen NP. An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures. Analytical and Bioanalytical Chemistry. 388: 871-9. PMID 17468853 DOI: 10.1007/S00216-007-1296-X |
0.346 |
|
| 2007 |
Kool J, Eggink M, van Rossum H, van Liempd SM, van Elswijk DA, Irth H, Commandeur JN, Meerman JH, Vermeulen NP. Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures. Journal of Biomolecular Screening. 12: 396-405. PMID 17379858 DOI: 10.1177/1087057107299527 |
0.393 |
|
| 2007 |
Bruyneel B, Hoos JS, Smoluch MT, Lingeman H, Niessen WM, Irth H. Trace analysis of proteins using postseparation solution-phase digestion and electrospray mass spectrometric detection of marker peptides. Analytical Chemistry. 79: 1591-8. PMID 17297960 DOI: 10.1021/Ac0616761 |
0.442 |
|
| 2007 |
Kool J, van Liempd SM, van Rossum H, van Elswijk DA, Irth H, Commandeur JN, Vermeulen NP. Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 640-8. PMID 17251308 DOI: 10.1124/Dmd.106.012245 |
0.399 |
|
| 2007 |
Krabbe JG, de Boer AR, van der Zwan G, Lingeman H, Niessen WM, Irth H. Metal-complex formation in continuous-flow ligand-exchange reactors studied by electrospray mass spectrometry. Journal of the American Society For Mass Spectrometry. 18: 707-13. PMID 17240160 DOI: 10.1016/J.Jasms.2006.12.006 |
0.374 |
|
| 2007 |
Marchesini GR, Koopal K, Meulenberg E, Haasnoot W, Irth H. Spreeta-based biosensor assays for endocrine disruptors. Biosensors & Bioelectronics. 22: 1908-15. PMID 16971108 DOI: 10.1016/J.Bios.2006.08.005 |
0.368 |
|
| 2007 |
de Boer AR, Lingeman H, Niessen WMA, Irth H. Mass spectrometry-based biochemical assays for enzyme-inhibitor screening Trac - Trends in Analytical Chemistry. 26: 867-883. DOI: 10.1016/J.Trac.2007.08.004 |
0.422 |
|
| 2006 |
Krabbe JG, Gao F, Li J, Ahlskog JE, Lingeman H, Niessen WM, Irth H. Selective detection and identification of phosphorylated proteins by simultaneous ligand-exchange fluorescence detection and mass spectrometry. Journal of Chromatography. A. 1130: 287-95. PMID 16820161 DOI: 10.1016/J.Chroma.2006.05.085 |
0.432 |
|
| 2006 |
van Liempd SM, Kool J, Niessen WM, van Elswijk DE, Irth H, Vermeulen NP. On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1640-9. PMID 16790557 DOI: 10.1124/Dmd.106.010355 |
0.411 |
|
| 2006 |
Kool J, Ramautar R, van Liempd SM, Beckman J, de Kanter FJ, Meerman JH, Schenk T, Irth H, Commandeur JN, Vermeulen NP. Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen. Journal of Medicinal Chemistry. 49: 3287-92. PMID 16722647 DOI: 10.1021/Jm0507936 |
0.346 |
|
| 2006 |
de Jong CF, Derks RJ, Bruyneel B, Niessen W, Irth H. High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. Journal of Chromatography. A. 1112: 303-10. PMID 16516896 DOI: 10.1016/J.Chroma.2006.01.059 |
0.482 |
|
| 2006 |
Marchesini GR, Meulenberg E, Haasnoot W, Mizuguchi M, Irth H. Biosensor recognition of thyroid-disrupting chemicals using transport proteins. Analytical Chemistry. 78: 1107-14. PMID 16478101 DOI: 10.1021/Ac051399I |
0.36 |
|
| 2006 |
Hoos JS, Sudergat H, Hoelck JP, Stahl M, de Vlieger JS, Niessen WM, Lingeman H, Irth H. Selective quantitative bioanalysis of proteins in biological fluids by on-line immunoaffinity chromatography-protein digestion-liquid chromatography-mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 830: 262-9. PMID 16311081 DOI: 10.1016/J.Jchromb.2005.11.002 |
0.447 |
|
| 2006 |
Letzel T, Derks RJ, Martha CT, van Marle A, Irth H. Sensitive determination of G-protein-coupled receptor binding ligands by solid phase extraction-electrospray ionization-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 40: 744-51. PMID 16307861 DOI: 10.1016/J.Jpba.2005.10.005 |
0.464 |
|
| 2006 |
Derks RJE, Letzel T, De Jong CF, Van Marle A, Lingeman H, Leurs R, Irth H. SEC-MS as an approach to isolate and directly identifying small molecular GPCR-ligands from complex mixtures without labeling Chromatographia. 64: 379-385. DOI: 10.1365/S10337-006-0058-9 |
0.391 |
|
| 2005 |
de Boer AR, Alcaide-Hidalgo JM, Krabbe JG, Kolkman J, van Emde Boas CN, Niessen WM, Lingeman H, Irth H. High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection. Analytical Chemistry. 77: 7894-900. PMID 16351135 DOI: 10.1021/Ac0510282 |
0.463 |
|
| 2005 |
Nuengchamnong N, de Jong CF, Bruyneel B, Niessen WM, Irth H, Ingkaninan K. HPLC coupled on-line to ESI-MS and a DPPH-based assay for the rapid identification of anti-oxidants in Butea superba. Phytochemical Analysis : Pca. 16: 422-8. PMID 16315486 DOI: 10.1002/Pca.865 |
0.42 |
|
| 2005 |
de Boer AR, Bruyneel B, Krabbe JG, Lingeman H, Niessen WM, Irth H. A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry. Lab On a Chip. 5: 1286-92. PMID 16234953 DOI: 10.1039/B506559C |
0.511 |
|
| 2005 |
Krabbe JG, Lingeman H, Niessen WM, Irth H. Screening for metal ligands by liquid chromatography--ligand-exchange--electrospray mass spectrometry. Journal of Chromatography. A. 1093: 36-46. PMID 16233869 DOI: 10.1016/J.Chroma.2005.07.022 |
0.421 |
|
| 2005 |
Carol J, Gorseling MC, de Jong CF, Lingeman H, Kientz CE, van Baar BL, Irth H. Determination of denaturated proteins and biotoxins by on-line size-exclusion chromatography-digestion-liquid chromatography-electrospray mass spectrometry. Analytical Biochemistry. 346: 150-7. PMID 16185643 DOI: 10.1016/J.Ab.2005.08.023 |
0.454 |
|
| 2005 |
Kool J, van Liempd SM, Ramautar R, Schenk T, Meerman JH, Irth H, Commandeur JN, Vermeulen NP. Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography. Journal of Biomolecular Screening. 10: 427-36. PMID 16093552 DOI: 10.1177/1087057105274904 |
0.404 |
|
| 2005 |
Hirata J, Chung LP, Ariese F, Irth H, Gooijer C. Coupling of size-exclusion chromatography to a continuous assay for subtilisin using a fluorescence resonance energy transfer peptide substrate: testing of two standard inhibitors. Journal of Chromatography. A. 1081: 140-4. PMID 16038203 DOI: 10.1016/J.Chroma.2005.05.016 |
0.401 |
|
| 2005 |
van Liempd SM, Kool J, Reinen J, Schenk T, Meerman JH, Irth H, Vermeulen NP. Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography. Journal of Chromatography. A. 1075: 205-12. PMID 15974134 DOI: 10.1016/J.Chroma.2005.03.084 |
0.404 |
|
| 2005 |
Visser NF, Lingeman H, Irth H. Sample preparation for peptides and proteins in biological matrices prior to liquid chromatography and capillary zone electrophoresis. Analytical and Bioanalytical Chemistry. 382: 535-58. PMID 15834556 DOI: 10.1007/S00216-005-3120-9 |
0.403 |
|
| 2005 |
de Boer AR, Letzel T, Lingeman H, Irth H. Systematic development of an enzymatic phosphorylation assay compatible with mass spectrometric detection. Analytical and Bioanalytical Chemistry. 381: 647-55. PMID 15703914 DOI: 10.1007/S00216-005-3070-2 |
0.424 |
|
| 2005 |
Visser NFC, Lingeman H, Li KW, Irth H. Quantitative transfer of in-gel digest products to liquid chromatography-electrospray mass spectrometry using on-line coupled extraction Chromatographia. 61: 433-442. DOI: 10.1365/S10337-005-0532-9 |
0.409 |
|
| 2005 |
Akoto L, Pel R, Irth H, Brinkman UAT, Vreuls RJJ. Automated GC-MS analysis of raw biological samples: Application to fatty acid profiling of aquatic micro-organisms Journal of Analytical and Applied Pyrolysis. 73: 69-75. DOI: 10.1016/J.Jaap.2004.11.006 |
0.319 |
|
| 2005 |
Marchesini GR, Meulenberg E, Haasnoot W, Irth H. Biosensor immunoassays for the detection of bisphenol A Analytica Chimica Acta. 528: 37-45. DOI: 10.1016/J.Aca.2004.06.066 |
0.398 |
|
| 2004 |
Hirata J, de Jong CF, van Dongen MM, Buijs J, Ariese F, Irth H, Gooijer C. A flow injection kinase assay system based on time-resolved fluorescence resonance energy-transfer detection in the millisecond range. Analytical Chemistry. 76: 4292-8. PMID 15283563 DOI: 10.1021/Ac049465O |
0.301 |
|
| 2004 |
de Boer AR, Letzel T, van Elswijk DA, Lingeman H, Niessen WM, Irth H. On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry. Analytical Chemistry. 76: 3155-61. PMID 15167796 DOI: 10.1021/Ac035380W |
0.475 |
|
| 2004 |
van Elswijk DA, Schobel UP, Lansky EP, Irth H, van der Greef J. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry. 65: 233-41. PMID 14732284 DOI: 10.1016/J.Phytochem.2003.07.001 |
0.431 |
|
| 2003 |
Krabbe JG, Lingeman H, Niessen WM, Irth H. Ligand-exchange detection of phosphorylated peptides using liquid chromatography electrospray mass spectrometry. Analytical Chemistry. 75: 6853-60. PMID 14670045 DOI: 10.1021/Ac0349476 |
0.466 |
|
| 2003 |
van Elswijk DA, Diefenbach O, van der Berg S, Irth H, Tjaden UR, van der Greef J. Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry. Journal of Chromatography. A. 1020: 45-58. PMID 14661756 DOI: 10.1016/J.Chroma.2003.08.055 |
0.469 |
|
| 2003 |
Schenk T, Molendijk A, Irth H, Tjaden UR, van der Greef J. Liquid chromatography coupled on-line to flow cytometry for postcolumn homogeneous biochemical detection. Analytical Chemistry. 75: 4272-8. PMID 14632146 DOI: 10.1021/Ac0341822 |
0.434 |
|
| 2003 |
Derks RJ, Hogenboom AC, van der Zwan G, Irth H. On-line continuous-flow, multi-protein biochemical assays for the characterization of bioaffinity compounds using electrospray quadrupole time-of-flight mass spectrometry. Analytical Chemistry. 75: 3376-84. PMID 14570187 DOI: 10.1021/Ac026423W |
0.404 |
|
| 2003 |
Schenk T, Breel GJ, Koevoets P, van den Berg S, Hogenboom AC, Irth H, Tjaden UR, van der Greef J. Screening of natural products extracts for the presence of phosphodiesterase inhibitors using liquid chromatography coupled online to parallel biochemical detection and chemical characterization. Journal of Biomolecular Screening. 8: 421-9. PMID 14567794 DOI: 10.1177/1087057103255973 |
0.437 |
|
| 2003 |
Visser NF, van Harmelen M, Lingeman H, Irth H. On-line SPE-CE for the determination of insulin derivatives in biological fluids. Journal of Pharmaceutical and Biomedical Analysis. 33: 451-62. PMID 14550864 DOI: 10.1016/S0731-7085(03)00292-9 |
0.332 |
|
| 2003 |
Visser NF, Lingeman H, Irth H. On-line SPE-RP-LC for the determination of insulin derivatives in biological matrices. Journal of Pharmaceutical and Biomedical Analysis. 32: 295-309. PMID 12763539 DOI: 10.1016/S0731-7085(02)00730-6 |
0.413 |
|
| 2003 |
Schenk T, Appels NM, van Elswijk DA, Irth H, Tjaden UR, van der Greef J. A generic assay for phosphate-consuming or -releasing enzymes coupled on-line to liquid chromatography for lead finding in natural products. Analytical Biochemistry. 316: 118-26. PMID 12694734 DOI: 10.1016/S0003-2697(03)00038-1 |
0.453 |
|
| 2003 |
Visser N, Lingeman H, Irth H. On-line Coupling of Three-Dimensional Liquid Chromatography Based Sample Preparation with Reversed-Phase Liquid Chromatography for the Determination of Enkephalin Derivatives as Model Compounds in Biofluids Chromatographia. 58: 691-699. DOI: 10.1365/S10337-003-0102-Y |
0.455 |
|
| 2003 |
Hirata J, Ariese F, Gooijer C, Irth H. Continuous-flow protease assay based on fluorescence resonance energy transfer Analytica Chimica Acta. 478: 1-10. DOI: 10.1016/S0003-2670(02)01436-8 |
0.36 |
|
| 2002 |
García MC, Hogenboom AC, Zappey H, Irth H. Effect of the mobile phase composition on the separation and detection of intact proteins by reversed-phase liquid chromatography-electrospray mass spectrometry. Journal of Chromatography. A. 957: 187-99. PMID 12113342 DOI: 10.1016/S0021-9673(02)00345-X |
0.437 |
|
| 2002 |
Van Elswijk DA, Irth H. Analytical tools for the detection and characterization of biologically active compounds from nature Phytochemistry Reviews. 1: 427-439. DOI: 10.1023/A:1026089809218 |
0.363 |
|
| 2001 |
Schobel U, Frenay M, van Elswijk DA, McAndrews JM, Long KR, Olson LM, Bobzin SC, Irth H. High resolution screening of plant natural product extracts for estrogen receptor alpha and beta binding activity using an online HPLC-MS biochemical detection system. Journal of Biomolecular Screening. 6: 291-303. PMID 11689129 DOI: 10.1177/108705710100600503 |
0.434 |
|
| 2001 |
Schenk T, Irth H, Marko-Varga G, Edholm LE, Tjaden UR, van der Greef J. Potential of on-line micro-LC immunochemical detection in the bioanalysis of cytokines. Journal of Pharmaceutical and Biomedical Analysis. 26: 975-85. PMID 11600310 DOI: 10.1016/S0731-7085(01)00464-2 |
0.333 |
|
| 2001 |
Hogenboom AC, de Boer AR, Derks RJ, Irth H. Continuous-flow, on-line monitoring of biospecific interactions using electrospray mass spectrometry. Analytical Chemistry. 73: 3816-23. PMID 11534702 DOI: 10.1021/Ac010026O |
0.456 |
|
| 2001 |
Van Elswijk DA, Tjaden UR, Van der Greef J, Irth H. Mass spectrometry-based bioassay for the screening of soluble orphan receptors International Journal of Mass Spectrometry. 210: 625-636. DOI: 10.1016/S1387-3806(01)00445-6 |
0.46 |
|
| 2000 |
Visser SA, Smulders CJ, Gladdines WW, Irth H, van der Graaf PH, Danhof M. High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats. Journal of Chromatography. B, Biomedical Sciences and Applications. 745: 357-63. PMID 11043754 DOI: 10.1016/S0378-4347(00)00296-6 |
0.438 |
|
| 2000 |
Mazereeuw M, de Best CM, Tjaden UR, Irth H, van der Greef J. Free flow electrophoresis device for continuous on-line separation in analytical systems. An application in biochemical detection. Analytical Chemistry. 72: 3881-6. PMID 10959977 DOI: 10.1021/Ac991202K |
0.415 |
|
| 2000 |
van Bommel MR, de Jong AP, Tjaden UR, Irth H, van der Greef J. High-performance liquid chromatography coupled to enzyme-amplified biochemical detection for the analysis of hemoglobin after pre-column biotinylation. Journal of Chromatography. A. 886: 19-29. PMID 10950272 DOI: 10.1016/S0021-9673(00)00481-7 |
0.48 |
|
| 2000 |
Ingkaninan K, Hazekamp A, de Best CM, Irth H, Tjaden UR, van der Heijden R, van der Greef J, Verpoorte R. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'. Journal of Natural Products. 63: 803-6. PMID 10869205 DOI: 10.1021/Np9905719 |
0.429 |
|
| 2000 |
Ingkaninan K, de Best CM, van der Heijden R, Hofte AJ, Karabatak B, Irth H, Tjaden UR, van der Greef J, Verpoorte R. High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products. Journal of Chromatography. A. 872: 61-73. PMID 10749487 DOI: 10.1016/S0021-9673(99)01292-3 |
0.398 |
|
| 1999 |
van Bommel MR, de Jong AP, Tjaden UR, Irth H, van der Greef J. Enzyme amplification as detection tool in continuous-flow systems. II. On-line coupling of liquid chromatography to enzyme-amplified biochemical detection after pre-column derivatization with biotin. Journal of Chromatography. A. 855: 397-409. PMID 10519083 DOI: 10.1016/S0021-9673(99)00745-1 |
0.353 |
|
| 1998 |
Oosterkamp AJ, van der Hoeven R, Glässgen W, König B, Tjaden UR, van der Greef J, Irth H. Gradient reversed-phase liquid chromatography coupled on-line to receptor-affinity detection based on the urokinase receptor. Journal of Chromatography. B, Biomedical Sciences and Applications. 715: 331-8. PMID 9792519 DOI: 10.1016/S0378-4347(98)00119-4 |
0.399 |
|
| 1998 |
Lindgren A, Emnéus J, Marko-Varga G, Irth H, Oosterkamp A, Eremin S. Optimisation of a heterogeneous non-competitive flow immunoassay comparing fluorescein, peroxidase and alkaline phosphatase as labels. Journal of Immunological Methods. 211: 33-42. PMID 9617829 DOI: 10.1016/S0022-1759(97)00169-5 |
0.324 |
|
| 1997 |
Lutz ES, Irth H, Tjaden UR, van der Greef J. Biochemical detection for direct bead surface analysis. Analytical Chemistry. 69: 4878-84. PMID 21639159 DOI: 10.1021/Ac970485I |
0.44 |
|
| 1997 |
Oostercamp AJ, Irth H, Tjaden UR, van der Greef J. Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. II. Detection systems based on labelled affinity proteins. Journal of Chromatography. A. 787: 37-46. PMID 9445650 DOI: 10.1016/S0021-9673(97)89244-8 |
0.337 |
|
| 1997 |
Oosterkamp AJ, Irth H, Villaverde Herraiz MT, Tjaden UR, van der Greef J. Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. I. Detection systems based on labelled ligands. Journal of Chromatography. A. 787: 27-35. PMID 9408993 DOI: 10.1016/S0021-9673(97)00646-8 |
0.325 |
|
| 1997 |
van der Hoeven RA, Hofte AJ, Frenay M, Irth H, Tjaden UR, van der Greef J, Rudolphi A, Boos KS, Marko Varga G, Edholm LE. Liquid chromatography-mass spectrometry with on-line solid-phase extraction by a restricted-access C18 precolumn for direct plasma and urine injection. Journal of Chromatography. A. 762: 193-200. PMID 9098977 DOI: 10.1016/S0021-9673(96)01004-7 |
0.379 |
|
| 1997 |
Oosterkamp AJ, Hock B, Seifert M, Irth H. Novel monitoring strategies for xenoestrogens Trac - Trends in Analytical Chemistry. 16: 544-553. DOI: 10.1016/S0165-9936(97)00099-X |
0.418 |
|
| 1996 |
Lutz ESM, Irth H, Tjaden UR, Van Der Greef J. Applying hollow fibres for separating free and bound label in continuous-flow immunochemical detection Journal of Chromatography A. 755: 179-187. PMID 8997748 DOI: 10.1016/S0021-9673(96)00620-6 |
0.306 |
|
| 1996 |
Oosterkamp AJ, Irth H, Heintz L, Marko-Varga G, Tjaden UR, Van Der Greef J. Simultaneous Determination of Cross-Heaetive Leukotrienes in Biological Matrices Using On-line Liquid Chromatography Immunochemical Detection Analytical Chemistry. 68: 4101-4106. PMID 8946791 DOI: 10.1021/Ac960250R |
0.464 |
|
| 1996 |
Oosterkamp AJ, Villaverde Herraiz MT, Irth H, Tjaden UR, Van Der Greet J. Reversed-phase liquid chromatography coupled on-line to receptor affinity detection based on the human estrogen receptor Analytical Chemistry. 68: 1201-1206. PMID 8651492 DOI: 10.1021/Ac950736S |
0.413 |
|
| 1995 |
Burestedt E, Emnéus J, Gorton L, Marko-Varga G, Domínguez E, Ortega F, Narváez A, Irth H, Lutz M, Puig D, Barceló D. Optimisation and validation of an automated solid phase extraction technique coupled on-line to enzyme-based biosensor detection for the determination of phenolic compounds in surface water samples Chromatographia. 41: 207-215. DOI: 10.1007/Bf02267957 |
0.437 |
|
| 1994 |
Oosterkamp AJ, Irth H, Beth M, Unger KK, Tjaden UR, van de Greef J. Bioanalysis of digoxin and its metabolites using direct serum injection combined with liquid chromatography and on-line immunochemical detection Journal of Chromatography B: Biomedical Sciences and Applications. 653: 55-61. PMID 8012560 DOI: 10.1016/0378-4347(93)E0405-F |
0.364 |
|
| 1994 |
Irth H, Cleton A, Mathôt RAA, Danhof M, IJzerman AP, Tjaden UR, van der Greef J. Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection Journal of Chromatography B: Biomedical Sciences and Applications. 658: 207-212. PMID 7952127 DOI: 10.1016/0378-4347(94)00216-9 |
0.324 |
|
| 1994 |
Oosterkamp AJ, Irth H, Tjaden UR, Van Der Greef J. On-line coupling of liquid chromatography to biochemical assays based on fluorescent-labeled ligands Analytical Chemistry. 66: 4295-4301. DOI: 10.1021/Ac00095A028 |
0.428 |
|
| 1994 |
Buscher BAP, Irth H, Andersson E, Tjaden UR, van der Greef J. Determination of inositol phosphates in fermentation broth using capillary zone electrophoresis with indirect UV detection Journal of Chromatography A. 678: 145-150. DOI: 10.1016/0021-9673(94)87084-5 |
0.404 |
|
| 1993 |
Reeuwijk HJEM, Irth H, Tjaden UR, Merkus FWHM, van der Greef J. Liquid chromatographic determination of β-cyclodextrin derivatives based on fluorescence enhancement after inclusion complexation Journal of Chromatography B: Biomedical Sciences and Applications. 614: 95-101. PMID 8496291 DOI: 10.1016/0378-4347(93)80227-U |
0.312 |
|
| 1993 |
Irth H. Laboratory experiments in liquid chromatography Journal of Chromatography A. 628: 321. DOI: 10.1016/0021-9673(93)80016-2 |
0.356 |
|
| 1992 |
Reinhoud NJ, Tjaden UR, Irth H, van der Greef J. Bioanalysis of some anthracyclines in human plasma by capillary electrophoresis with laser-induced fluorescence detection Journal of Chromatography B: Biomedical Sciences and Applications. 574: 327-334. PMID 1618967 DOI: 10.1016/0378-4347(92)80047-T |
0.339 |
|
| 1992 |
Venizelos V, Irth H, Tjaden UR, van der Greef J, Breimer DD, Mulders TM, Mulder GJ. Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction. Journal of Chromatography. 573: 259-64. PMID 1601958 DOI: 10.1016/0378-4347(92)80127-C |
0.332 |
|
| 1990 |
Irth H, de Jong GJ, Frei RW, Brinkman UAT. Determination of dithiocarbamates in residues by liquid chromatography with selective precolumn or reaction-detection systems International Journal of Environmental Analytical Chemistry. 39: 129-139. DOI: 10.1080/03067319008027689 |
0.643 |
|
| 1990 |
Irth H, Lamoree M, de Jong GJ, Brinkman UAT, Frei RW, Kornfeldt RA, Persson L. Determination of d-myo-1,2,6-inositol trisphosphate by ion-pair reversed-phase liquid chromatography with post-column ligand exchange and fluorescence detection Journal of Chromatography A. 499: 617-625. DOI: 10.1016/S0021-9673(00)97006-7 |
0.632 |
|
| 1990 |
Irth H, De Jong GJ, Lingeman H, Brinkman UAT. Liquid chromatographic determination of azidothymidine in human plasma using on-line dialysis and preconcentration on a silver(I)-thiol stationary phase Analytica Chimica Acta. 236: 165-172. DOI: 10.1016/S0003-2670(00)83310-3 |
0.472 |
|
| 1990 |
Irth H, Brinkman UAT. Ligand exchange for trace enrichment and selective detection of ionic compounds Trends in Analytical Chemistry. 9: 235-241. DOI: 10.1016/0165-9936(90)87128-9 |
0.469 |
|
| 1990 |
Marko-Varga G, Dominguez E, Hahn-Hägerdal B, Gorton L, Irth H, De Jong GJ, Frei RW, Brinkman UAT. On-line sample clean-up of fermentation broths and substrates prior to the liquid chromatographic separation of carbohydrates Journal of Chromatography A. 523: 173-188. DOI: 10.1016/0021-9673(90)85021-M |
0.647 |
|
| 1989 |
Irth H, Tocklu R, Welten K, de Jong GJ, Brinkman UA, Frei RW. Trace-level determination of 3'-azido-3'-deoxythymidine in human plasma by preconcentration on a silver (I)-thiol stationary phase with on-line reversed-phase high-performance liquid chromatography. Journal of Chromatography. 491: 321-30. PMID 2808618 DOI: 10.1016/S0378-4347(00)82850-9 |
0.702 |
|
| 1989 |
Irth H, Tocklu R, Welten K, de Jong GJ, Frei RW, Brinkman UA. Trace enrichment on a metal-loaded thiol stationary phase in liquid chromatography: effect of analyte structure and pH value on the (de)sorption behaviour. Journal of Pharmaceutical and Biomedical Analysis. 7: 1679-90. PMID 2490557 DOI: 10.1016/0731-7085(89)80182-7 |
0.68 |
|
| 1989 |
Irth H, De Jong GJ, Brinkman UAT, Frei RW. Determination of PbII CDII and BiIII by reversed-phase liquid chromatography of their diethyldithiocarbamate complexes with post-column ligand exchange and selective spectrophotometric detection Journal of Chromatography A. 482: 317-323. DOI: 10.1016/S0021-9673(01)83919-4 |
0.64 |
|
| 1989 |
Lipschitz C, Irth H, de Jong GJ, Brinkman UAT, Frei RW. Trace enrichment of pyrimidine nucleobases, 5-fluoro-uracil and bromacil on a silver-loaded thiol stationary phase with on-line reversed-phase high-performance liquid chromatography Journal of Chromatography A. 471: 321-334. DOI: 10.1016/S0021-9673(00)94180-3 |
0.643 |
|
| 1988 |
Irth H, de Jong GJ, Brinkman UA, Frei RW. Determination of disulfiram and two of its metabolites in urine by reversed-phase liquid chromatography and spectrophotometric detection after post-column complexation. Journal of Chromatography. 424: 95-102. PMID 2835384 DOI: 10.1016/S0378-4347(00)81079-8 |
0.694 |
|
| 1988 |
Irth H, Brouwer E, De Jong GJ, Brinkman UAT, Frei RW. Trace enrichment and separation of AsIII, SbIII and BiIII as diethyldithiophosphate complexes by reversed-phase high-performance liquid chromatography Journal of Chromatography A. 439: 63-70. DOI: 10.1016/S0021-9673(01)81675-7 |
0.638 |
|
| 1987 |
Irth H, Jong GJd, Brinkman UAT, Frei RW. Trace enrichment and separation of metal ions as dithiocarbamate complexes by liquid chromatography Analytical Chemistry. 59: 98-101. DOI: 10.1021/Ac00128A021 |
0.403 |
|
| 1987 |
Irth H, De Jong GJ, Brinkman UAT, Frei RW. Trace enrichment and separation of metal ions as dithiocarbamate complexes by liquid chromatography Analytical Chemistry. 59: 98-101. |
0.544 |
|
| 1986 |
Irth H, de Jong GJ, Brinkman UA, Frei RW. Metallic copper-containing post-column reactor for the detection of thiram and disulfiram in liquid chromatography. Journal of Chromatography. 370: 439-47. PMID 3818821 DOI: 10.1016/S0021-9673(00)94714-9 |
0.718 |
|
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