Kevin M. Crofton - Publications

Affiliations: 
Toxicology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Toxicology, Molecular Biology, Neuroscience Biology

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Medvedev AV, Medvedeva LA, Martsen E, Moeser M, Gorman KL, Lin B, Blackwell BR, Villeneuve DL, Houck KA, Crofton K, Makarov S. Harmonized cross-species assessment of endocrine and metabolic disruptors by Ecotox FACTORIAL assay. Environmental Science & Technology. PMID 32901485 DOI: 10.1021/Acs.Est.0C03375  0.326
2019 Paul-Friedman K, Martin M, Crofton KM, Hsu CW, Sakamuru S, Zhao J, Xia M, Huang R, Stavreva DA, Soni V, Varticovski L, Raziuddin R, Hager GL, Houck KA. Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library. Environmental Health Perspectives. 127: 97009. PMID 31566444 DOI: 10.1289/Ehp5314  0.331
2019 Noyes PD, Friedman KP, Browne P, Haselman JT, Gilbert ME, Hornung MW, Barone S, Crofton KM, Laws SC, Stoker TE, Simmons SO, Tietge JE, Degitz SJ. Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches. Environmental Health Perspectives. 127: 95001. PMID 31487205 DOI: 10.1289/Ehp5297  0.367
2018 Thomas RS, Paules RS, Simeonov A, Fitzpatrick SC, Crofton KM, Casey WM, Mendrick DL. The US Federal Tox21 Program: A strategic and operational plan for continued leadership. Altex. PMID 29529324 DOI: 10.14573/Altex.1803011  0.319
2018 Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, et al. Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. Altex. PMID 29485663 DOI: 10.14573/Altex.1712081  0.342
2018 Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Bennekou SH, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, et al. Recommendation on test readiness criteria for new approach methods(NAM) in toxicology: exemplified for developmental neurotoxicity(DNT) Altex-Alternatives to Animal Experimentation. 35: 306. DOI: 10.14573/Altex.1712081S  0.342
2016 Richard AM, Judson RS, Houck KA, Grulke CM, Volarath P, Thillainadarajah I, Yang C, Rathman JF, Martin MT, Wambaugh JF, Knudsen TB, Kancherla J, Mansouri K, Patlewicz GY, Williams AJ, ... ... Crofton KM, et al. The ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. Chemical Research in Toxicology. PMID 27367298 DOI: 10.1021/Acs.Chemrestox.6B00135  0.326
2016 Hughes MF, Ross DG, Starr JM, Scollon EJ, Wolansky MJ, Crofton KM, DeVito MJ. Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat. Toxicology. PMID 27330022 DOI: 10.1016/J.Tox.2016.06.013  0.358
2016 Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Setzer RW, Kothya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, ... ... Crofton K, et al. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27208079 DOI: 10.1093/Toxsci/Kfw092  0.33
2016 Johnstone AF, Strickland JD, Crofton KM, Gennings C, Shafer TJ. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. Neurotoxicology. PMID 27177986 DOI: 10.1016/J.Neuro.2016.05.005  0.315
2016 Paul Friedman K, Watt ED, Hornung MW, Hedge JM, Judson RS, Crofton KM, Houck KA, Simmons SO. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors within the ToxCast Phase I and II Chemical Libraries. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26884060 DOI: 10.1093/Toxsci/Kfw034  0.335
2015 Mundy WR, Padilla S, Breier JM, Crofton KM, Gilbert ME, Herr DW, Jensen KF, Radio NM, Raffaele KC, Schumacher K, Shafer TJ, Cowden J. Expanding the test set: Chemicals with potential to disrupt mammalian brain development. Neurotoxicology and Teratology. 52: 25-35. PMID 26476195 DOI: 10.1016/J.Ntt.2015.10.001  0.382
2015 Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, ... ... Crofton KM, et al. Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26272952 DOI: 10.1093/Toxsci/Kfv168  0.344
2015 Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, et al. International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Archives of Toxicology. 89: 269-87. PMID 25618548 DOI: 10.1007/S00204-015-1464-2  0.318
2014 Tollefsen KE, Scholz S, Cronin MT, Edwards SW, de Knecht J, Crofton K, Garcia-Reyero N, Hartung T, Worth A, Patlewicz G. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). Regulatory Toxicology and Pharmacology : Rtp. 70: 629-40. PMID 25261300 DOI: 10.1016/J.Yrtph.2014.09.009  0.321
2014 Judson R, Houck K, Martin M, Knudsen T, Thomas RS, Sipes N, Shah I, Wambaugh J, Crofton K. In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme. Basic & Clinical Pharmacology & Toxicology. 115: 69-76. PMID 24684691 DOI: 10.1111/Bcpt.12239  0.391
2014 Starr JM, Graham SE, Ross DG, Tornero-Velez R, Scollon EJ, Devito MJ, Crofton KM, Wolansky MJ, Hughes MF. Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats. Toxicology. 320: 15-24. PMID 24631210 DOI: 10.1016/J.Tox.2014.02.016  0.355
2014 Paul KB, Hedge JM, Rotroff DM, Hornung MW, Crofton KM, Simmons SO. Development of a thyroperoxidase inhibition assay for high-throughput screening. Chemical Research in Toxicology. 27: 387-99. PMID 24383450 DOI: 10.1021/Tx400310W  0.749
2013 Paul KB, Hedge JM, Macherla C, Filer DL, Burgess E, Simmons SO, Crofton KM, Hornung MW. Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat. Toxicology. 312: 97-107. PMID 23959146 DOI: 10.1016/J.Tox.2013.08.006  0.768
2013 Paul KB, Thompson JT, Simmons SO, Vanden Heuvel JP, Crofton KM. Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 2049-60. PMID 23899473 DOI: 10.1016/J.Tiv.2013.07.008  0.755
2013 Perkins EJ, Ankley GT, Crofton KM, Garcia-Reyero N, LaLone CA, Johnson MS, Tietge JE, Villeneuve DL. Current perspectives on the use of alternative species in human health and ecological hazard assessments. Environmental Health Perspectives. 121: 1002-10. PMID 23771518 DOI: 10.1289/Ehp.1306638  0.304
2013 Murk AJ, Rijntjes E, Blaauboer BJ, Clewell R, Crofton KM, Dingemans MM, Furlow JD, Kavlock R, Köhrle J, Opitz R, Traas T, Visser TJ, Xia M, Gutleb AC. Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1320-46. PMID 23453986 DOI: 10.1016/J.Tiv.2013.02.012  0.393
2013 Marshall S, Gennings C, Teuschler LK, Stork LG, Tornero-Velez R, Crofton KM, Rice GE. An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data. Risk Analysis : An Official Publication of the Society For Risk Analysis. 33: 1582-95. PMID 23398277 DOI: 10.1111/Risa.12015  0.363
2013 Fisher JW, Li S, Crofton K, Zoeller RT, McLanahan ED, Lumen A, Gilbert ME. Evaluation of iodide deficiency in the lactating rat and pup using a biologically based dose-response model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 75-86. PMID 23288054 DOI: 10.1093/Toxsci/Kfs336  0.412
2013 Gilbert ME, Hedge JM, Valentín-Blasini L, Blount BC, Kannan K, Tietge J, Zoeller RT, Crofton KM, Jarrett JM, Fisher JW. An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 177-95. PMID 23288053 DOI: 10.1093/Toxsci/Kfs335  0.372
2013 Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS. Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Environmental Health Perspectives. 121: 7-14. PMID 23052129 DOI: 10.1289/Ehp.1205065  0.34
2013 Kleinstreuer NC, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Paul KB, Reif DM, Crofton KM, Hamilton K, Hunter R, Shah I, Judson RS. In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 131: 40-55. PMID 23024176 DOI: 10.1093/Toxsci/Kfs285  0.753
2012 Crofton KM, Mundy WR, Shafer TJ. Developmental neurotoxicity testing: a path forward. Congenital Anomalies. 52: 140-6. PMID 22925214 DOI: 10.1111/J.1741-4520.2012.00377.X  0.35
2012 Tsuji R, Crofton KM. Developmental neurotoxicity guideline study: issues with methodology, evaluation and regulation. Congenital Anomalies. 52: 122-8. PMID 22925212 DOI: 10.1111/J.1741-4520.2012.00374.X  0.344
2012 Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. Altex. 29: 202-15. PMID 22892558 DOI: 10.14573/Altex.2012.2.202  0.336
2012 Starr JM, Scollon EJ, Hughes MF, Ross DG, Graham SE, Crofton KM, Wolansky MJ, Devito MJ, Tornero-Velez R. Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 309-18. PMID 22872056 DOI: 10.1093/Toxsci/Kfs245  0.392
2012 Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. Toxicology. 300: 31-45. PMID 22659317 DOI: 10.1016/J.Tox.2012.05.023  0.776
2012 Piersma AH, Tonk ECM, Makris SL, Crofton KM, Dietert RR, van Loveren H. Juvenile toxicity testing protocols for chemicals Reproductive Toxicology. 34: 482-486. PMID 22564981 DOI: 10.1016/J.Reprotox.2012.04.010  0.38
2011 Scollon EJ, Starr JM, Crofton KM, Wolansky MJ, DeVito MJ, Hughes MF. Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat. Toxicology. 290: 1-6. PMID 21854826 DOI: 10.1016/J.Tox.2011.08.002  0.369
2011 Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Raaij MV, Vickers C. Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework. Regulatory Toxicology and Pharmacology : Rtp. PMID 21466831 DOI: 10.1016/J.Yrtph.2011.03.010  0.328
2011 Gilbert ME, McLanahan ED, Hedge J, Crofton KM, Fisher JW, Valentín-Blasini L, Blount BC. Marginal iodide deficiency and thyroid function: Dose-response analysis for quantitative pharmacokinetic modeling Toxicology. 283: 41-48. PMID 21315791 DOI: 10.1016/J.Tox.2011.02.001  0.397
2011 Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AE, Knaut H, Buzanska L, Goldberg A. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. Altex. 28: 9-15. PMID 21311847 DOI: 10.14573/Altex.2011.1.009  0.32
2011 Boobis A, Budinsky R, Collie S, Crofton K, Embry M, Felter S, Hertzberg R, Kopp D, Mihlan G, Mumtaz M, Price P, Solomon K, Teuschler L, Yang R, Zaleski R. Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment. Critical Reviews in Toxicology. 41: 369-83. PMID 21309635 DOI: 10.3109/10408444.2010.543655  0.378
2011 Watanabe KH, Andersen ME, Basu N, Carvan MJ, Crofton KM, King KA, Suñol C, Tiffany-Castiglioni E, Schultz IR. Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental Toxicology and Chemistry / Setac. 30: 9-21. PMID 20963854 DOI: 10.1002/Etc.373  0.317
2011 Raffaele K, Bergfeldt D, Burgess-Herbert S, Crofton K, Diwan S, Makris S, Segal D, Gilbert M. Next Generation Risk Assessment and Developmental Neurotoxicity: Potential and Challenges in Evaluation of the Thyroid Hormonal Pathway Neurotoxicology and Teratology. 33: 506. DOI: 10.1016/J.Ntt.2011.05.051  0.315
2010 Paul KB, Hedge JM, Devito MJ, Crofton KM. Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats. Environmental Toxicology and Chemistry / Setac. 29: 2840-4. PMID 20954233 DOI: 10.1002/Etc.339  0.767
2010 Bushnell PJ, Kavlock RJ, Crofton KM, Weiss B, Rice DC. Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009. Neurotoxicology and Teratology. 32: 313-28. PMID 20171276 DOI: 10.1016/J.Ntt.2010.02.002  0.381
2010 Harrill JA, Knapp GW, Crofton KM. Splice variant specific increase in Ca2+/calmodulin-dependent protein kinase 1-gamma mRNA expression in response to acute pyrethroid exposure. Journal of Biochemical and Molecular Toxicology. 24: 174-86. PMID 20143453 DOI: 10.1002/Jbt.20324  0.694
2010 Paul KB, Hedge JM, DeVito MJ, Crofton KM. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 113: 367-79. PMID 19910387 DOI: 10.1093/Toxsci/Kfp271  0.768
2010 Ryan BC, Hotchkiss AK, Crofton KM, Gray LE. In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 114: 133-48. PMID 19864446 DOI: 10.1093/Toxsci/Kfp266  0.401
2010 Hedge JM, DeVito MJ, Crofton KM. In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats. International Journal of Toxicology. 28: 382-91. PMID 19815845 DOI: 10.1177/1091581809344631  0.457
2010 Gilbert M, Crofton K, Nelson G, Knapp G. Gene expression in developing brain is altered by modest reductions in circulating levels of thyroid hormone Neurotoxicology and Teratology. 32: 504. DOI: 10.1016/J.Ntt.2010.04.029  0.301
2009 Wolansky MJ, Gennings C, DeVito MJ, Crofton KM. Evidence for dose-additive effects of pyrethroids on motor activity in rats. Environmental Health Perspectives. 117: 1563-70. PMID 20019907 DOI: 10.1289/Ehp.0900667  0.335
2009 Flippin JL, Hedge JM, DeVito MJ, Leblanc GA, Crofton KM. Predictive modeling of a mixture of thyroid hormone disrupting chemicals that affect production and clearance of thyroxine. International Journal of Toxicology. 28: 368-81. PMID 19815844 DOI: 10.1177/1091581809341883  0.327
2009 Miller MD, Crofton KM, Rice DC, Zoeller RT. Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes. Environmental Health Perspectives. 117: 1033-41. PMID 19654909 DOI: 10.1289/Ehp.0800247  0.379
2009 Makris SL, Raffaele K, Allen S, Bowers WJ, Hass U, Alleva E, Calamandrei G, Sheets L, Amcoff P, Delrue N, Crofton KM. A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. Environmental Health Perspectives. 117: 17-25. PMID 19165382 DOI: 10.1289/Ehp.11447  0.306
2009 Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 107: 56-64. PMID 18940961 DOI: 10.1093/Toxsci/Kfn225  0.461
2009 Crofton K. Developmental neurotoxicity and thyroid hormone disruptors: Past, present and future Neurotoxicology and Teratology. 31: 237-238. DOI: 10.1016/J.Ntt.2009.04.008  0.309
2008 Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller M, Miller GG, Schwartz JM, Alexeeff G, Anderson H, Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, et al. Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environmental Health Perspectives. 116: 1568-75. PMID 19057713 DOI: 10.1289/Ehp.11516  0.335
2008 Harrill JA, Li Z, Wright FA, Radio NM, Mundy WR, Tornero-Velez R, Crofton KM. Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. Bmc Genomics. 9: 546. PMID 19017407 DOI: 10.1186/1471-2164-9-546  0.693
2008 Crofton KM. Thyroid disrupting chemicals: mechanisms and mixtures. International Journal of Andrology. 31: 209-23. PMID 18217984 DOI: 10.1111/J.1365-2605.2007.00857.X  0.399
2008 Tyl RW, Crofton K, Moretto A, Moser V, Sheets LP, Sobotka TJ. Identification and interpretation of developmental neurotoxicity effects. A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints Neurotoxicology and Teratology. 30: 349-381. PMID 17826946 DOI: 10.1016/J.Ntt.2007.07.008  0.325
2008 Crofton KM, Foss JA, Hass U, Jensen KF, Levin ED, Parker SP. Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicology and Teratology. 30: 266-87. PMID 17681747 DOI: 10.1016/J.Ntt.2007.06.002  0.317
2007 Crofton KM, Paul KB, Devito MJ, Hedge JM. Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. Environmental Toxicology and Pharmacology. 24: 194-7. PMID 21783810 DOI: 10.1016/J.Etap.2007.04.008  0.786
2007 McLanahan ED, Campbell JL, Ferguson DC, Harmon B, Hedge JM, Crofton KM, Mattie DR, Braverman L, Keys DA, Mumtaz M, Fisher JW. Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 308-17. PMID 17379623 DOI: 10.1093/Toxsci/Kfm063  0.435
2007 Pacyniak EK, Cheng X, Cunningham ML, Crofton K, Klaassen CD, Guo GL. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 94-102. PMID 17324954 DOI: 10.1093/Toxsci/Kfm025  0.309
2007 Wolansky MJ, McDaniel KL, Moser VC, Crofton KM. Influence of dosing volume on the neurotoxicity of bifenthrin. Neurotoxicology and Teratology. 29: 377-84. PMID 17321720 DOI: 10.1016/J.Ntt.2007.01.007  0.36
2007 Crofton KM, Harrill JA, Wolansky MJ. Comments on: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings [Johri et al. Toxicol Appl Pharmacol. 214:279-289, 2006]. Toxicology and Applied Pharmacology. 218: 96-7; author reply 9. PMID 17157340 DOI: 10.1016/J.Taap.2006.10.020  0.659
2007 Herr DW, Graff JE, Moser VC, Crofton KM, Little PB, Morgan DL, Sills RC. Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 95: 118-35. PMID 17079700 DOI: 10.1093/Toxsci/Kfl146  0.349
2007 Gennings C, Carter WH, Carchman RA, De Vito MJ, Simmons JE, Crofton KM. The impact of exposure to a mixture of eighteen polyhalogenated aromatic hydrocarbons on thyroid function: Estimation of an interaction threshold Journal of Agricultural, Biological, and Environmental Statistics. 12: 96-111. DOI: 10.1198/108571107X176727  0.332
2006 Crofton KM. Bromate: concern for developmental neurotoxicity? Toxicology. 221: 212-6. PMID 16516369 DOI: 10.1016/J.Tox.2006.01.021  0.379
2006 Fisher JW, Campbell J, Muralidhara S, Bruckner JV, Ferguson D, Mumtaz M, Harmon B, Hedge JM, Crofton KM, Kim H, Almekinder TL. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 90: 87-95. PMID 16339789 DOI: 10.1093/Toxsci/Kfj069  0.433
2006 Wolansky MJ, Gennings C, Crofton KM. Relative potencies for acute effects of pyrethroids on motor function in rats Toxicological Sciences. 89: 271-277. PMID 16221961 DOI: 10.1093/Toxsci/Kfj020  0.368
2005 Zoeller RT, Crofton KM. Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil. Critical Reviews in Toxicology. 35: 771-81. PMID 16417044 DOI: 10.1080/10408440591007313  0.38
2005 Crofton KM, Zoeller RT. Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hearing loss resulting from exposure to PHAHs. Critical Reviews in Toxicology. 35: 757-69. PMID 16417043 DOI: 10.1080/10408440591007304  0.394
2005 Crofton KM, Craft ES, Hedge JM, Gennings C, Simmons JE, Carchman RA, Carter WH, DeVito MJ. Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environmental Health Perspectives. 113: 1549-54. PMID 16263510 DOI: 10.1289/Ehp.8195  0.429
2005 Harrill JA, Meacham CA, Shafer TJ, Hughes MF, Crofton KM. Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes. Toxicology Letters. 157: 79-88. PMID 15795096 DOI: 10.1016/J.Toxlet.2005.01.006  0.676
2005 Shafer TJ, Meyer DA, Crofton KM. Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environmental Health Perspectives. 113: 123-36. PMID 15687048 DOI: 10.1289/Ehp.7254  0.348
2005 Crofton KM. Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats. Risk Analysis : An Official Publication of the Society For Risk Analysis. 24: 1665-71. PMID 15660619 DOI: 10.1111/J.0272-4332.2004.00557.X  0.442
2004 Mundy WR, Freudenrich TM, Crofton KM, DeVito MJ. Accumulation of PBDE-47 in primary cultures of rat neocortical cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 82: 164-9. PMID 15282408 DOI: 10.1093/Toxsci/Kfh239  0.346
2004 Crofton KM, Makris SL, Sette WF, Mendez E, Raffaele KC. A qualitative retrospective analysis of positive control data in developmental neurotoxicity studies Neurotoxicology and Teratology. 26: 345-352. PMID 15113596 DOI: 10.1016/J.Ntt.2004.02.007  0.332
2004 Stoker TE, Laws SC, Crofton KM, Hedge JM, Ferrell JM, Cooper RL. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicological Sciences : An Official Journal of the Society of Toxicology. 78: 144-55. PMID 14999130 DOI: 10.1093/Toxsci/Kfh029  0.413
2002 Lasky RE, Widholm JJ, Crofton KM, Schantz SL. Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 458-64. PMID 12151642 DOI: 10.1093/Toxsci/68.2.458  0.365
2002 Craft ES, DeVito MJ, Crofton KM. Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 372-80. PMID 12151633 DOI: 10.1093/Toxsci/68.2.372  0.413
2002 Taylor MM, Crofton KM, MacPhail RC. Schedule-controlled behavior in rats exposed perinatally to the PCB mixture Aroclor 1254. Neurotoxicology and Teratology. 24: 511-8. PMID 12127897 DOI: 10.1016/S0892-0362(02)00205-2  0.363
2002 Zhou T, Taylor MM, DeVito MJ, Crofton KM. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicological Sciences : An Official Journal of the Society of Toxicology. 66: 105-16. PMID 11861977 DOI: 10.1093/Toxsci/66.1.105  0.452
2002 Herr DW, Graff JE, Derr-Yellin EC, Crofton KM, Kodavanti PR. Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254. Neurotoxicology and Teratology. 23: 591-601. PMID 11792527 DOI: 10.1016/S0892-0362(01)00180-5  0.363
2001 Widholm JJ, Clarkson GB, Strupp BJ, Crofton KM, Seegal RF, Schantz SL. Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory control. Toxicology and Applied Pharmacology. 174: 188-98. PMID 11446834 DOI: 10.1006/Taap.2001.9199  0.37
2001 Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 61: 76-82. PMID 11294977 DOI: 10.1093/Toxsci/61.1.76  0.451
2001 Cory-Slechta DA, Crofton KM, Foran JA, Ross JF, Sheets LP, Weiss B, Mileson B. Methods to identify and characterize developmental neurotoxicity for human health risk assessment. I: behavioral effects. Environmental Health Perspectives. 109: 79-91. PMID 11250808 DOI: 10.1289/Ehp.01109S179  0.341
2000 Crofton KM, Kodavanti PRS, Derr-Yellin EC, Casey AC, Kehn LS. PCBs, thyroid hormones, and ototoxicity in rats: Cross-fostering experiments demonstrate the impact of postnatal lactation exposure Toxicological Sciences. 57: 131-140. PMID 10966519 DOI: 10.1093/Toxsci/57.1.131  0.331
2000 Roegge CS, Seo BW, Crofton KM, Schantz SL. Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 57: 121-30. PMID 10966518 DOI: 10.1093/Toxsci/57.1.121  0.326
2000 Gilbert ME, Mundy WR, Crofton KM. Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254 Toxicological Sciences. 57: 102-111. PMID 10966516 DOI: 10.1093/Toxsci/57.1.102  0.32
2000 Crofton KM, Ding DL, Padich R, Taylor M, Henderson D. Hearing loss following exposure during development to polychlorinated biphenyls: A cochlear site of action Hearing Research. 144: 196-204. PMID 10831878 DOI: 10.1016/S0378-5955(00)00062-9  0.347
2000 Boyes WK, Bushnell PJ, Crofton KM, Evans M, Simmons JE. Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario. Environmental Health Perspectives. 108: 317-22. PMID 10807561 DOI: 10.1289/Ehp.00108S2317  0.385
1999 Crofton KM, Rice DC. Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats. Neurotoxicology and Teratology. 21: 299-301. PMID 10386834 DOI: 10.1016/S0892-0362(98)00065-8  0.403
1999 DeVito M, Biegel L, Brouwer A, Brown S, Brucker-Davis F, Cheek AO, Christensen R, Colborn T, Cooke P, Crissman J, Crofton K, Doerge D, Gray E, Hauser P, Hurley P, et al. Screening methods for thyroid hormone disruptors. Environmental Health Perspectives. 107: 407-15. PMID 10210697 DOI: 10.1289/Ehp.99107407  0.357
1998 Fechter LD, Liu Y, Herr DW, Crofton KM. Trichloroethylene ototoxicity: Evidence for a cochlear origin Toxicological Sciences. 42: 28-35. PMID 9538045 DOI: 10.1006/Toxs.1997.2413  0.334
1998 Goldey ES, Crofton KM. Thyroxine Replacement Attenuates Hypothyroxinemia, Hearing Loss, and Motor Deficits Following Developmental Exposure to Aroclor 1254 in Rats Toxicological Sciences. 45: 94-105. DOI: 10.1093/Toxsci/45.1.94  0.375
1997 Nace CG, Genter MB, Sayre LM, Crofton KM. Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 37: 131-40. PMID 9242586 DOI: 10.1006/Faat.1997.2307  0.413
1997 Crofton KM, Zhao X. The Ototoxicity of Trichloroethylene: Extrapolation and Relevance of High-Concentration, Short-Duration Animal Exposure Data Toxicological Sciences. 38: 101-106. DOI: 10.1093/Toxsci/38.1.101  0.407
1996 Tilson HA, MacPhail RC, Crofton KM. Setting exposure standards: A decision process Environmental Health Perspectives. 104: 401-405. PMID 9182048 DOI: 10.1289/Ehp.96104S2401  0.335
1996 Genter MB, Owens DM, Carlone HB, Crofton KM. Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole Fundamental and Applied Toxicology. 29: 71-77. PMID 8838641 DOI: 10.1006/Faat.1996.0007  0.318
1996 Herr DW, King D, Barone S, Crofton KM. Alterations in flash evoked potentials (FEPs) in rats produced by 3,3'-iminodipropionitrile (IDPN). Neurotoxicology and Teratology. 17: 645-56. PMID 8747746 DOI: 10.1016/0892-0362(95)02007-1  0.34
1996 Crofton KM, Zhao X, Sayre LM, Genter MB. Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and Teratology. 18: 297-303. PMID 8725642 DOI: 10.1016/S0892-0362(96)90031-8  0.398
1996 Crofton KM, Padilla S, Tilson HA, Anthony DC, Raymer JH, MacPhail RC. The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects. Toxicology and Applied Pharmacology. 139: 163-76. PMID 8685900 DOI: 10.1006/Taap.1996.0155  0.406
1996 Crofton KM. A structure-activity relationship for the neurotoxicity of triazole fungicides. Toxicology Letters. 84: 155-9. PMID 8600615 DOI: 10.1016/0378-4274(95)03618-0  0.378
1996 Stanton ME, Crofton KM, Gray LE, Gordon CJ, Boyes WK, Mole ML, Peele DB, Bushnell PJ. Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 28: 100-10. PMID 8566474 DOI: 10.1006/Faat.1995.1151  0.446
1996 HERR DW, GOLDEY ES, CROFTON KM. Developmental Exposure to Aroclor 1254 Produces Low-Frequency Alterations in Adult Rat Brainstem Auditory Evoked Responses Toxicological Sciences. 33: 120-128. DOI: 10.1093/Toxsci/33.1.120  0.363
1995 Crofton KM, Janssen R, Prazma J, Pulver S, Barone S. The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage. Hearing Research. 80: 129-40. PMID 7896571 DOI: 10.1016/0378-5955(94)90104-X  0.352
1995 Llorens J, Crofton KM, Peele DB. Effects of 3,3'-iminodipropionitrile on acquisition and performance of spatial tasks in rats. Neurotoxicology and Teratology. 16: 583-91. PMID 7862057 DOI: 10.1016/0892-0362(94)90036-1  0.36
1995 Goldey ES, O'Callaghan JP, Stanton ME, Barone S, Crofton KM. Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 447-64. PMID 7835545 DOI: 10.1006/Faat.1994.1127  0.424
1995 Crofton KM, Kehn LS, Gilbert ME. Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat Neurotoxicology and Teratology. 17: 489-495. PMID 7565495 DOI: 10.1016/0892-0362(95)00008-F  0.35
1995 Goldey ES, Tilson HA, Crofton KM. Implications of the use of neonatal birth weight, growth, viability, and survival data for predicting developmental neurotoxicity: A survey of the literature Neurotoxicology and Teratology. 17: 313-332. PMID 7542737 DOI: 10.1016/0892-0362(94)00073-M  0.331
1995 Goldey ES, Kehn LS, Lau C, Rehnberg GL, Crofton KM. Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicology and Applied Pharmacology. 135: 77-88. PMID 7482542 DOI: 10.1006/Taap.1995.1210  0.44
1995 Goldey ES, Kehn LS, Rehnberg GL, Crofton KM. Effects of developmental hypothyroidism on auditory and motor function in the rat. Toxicology and Applied Pharmacology. 135: 67-76. PMID 7482541 DOI: 10.1006/Taap.1995.1209  0.44
1995 Stanton ME, Crofton KM, Gray LE, Gordon CJ, Boyes WK, Mole ML, Peele DB, Bushnell PJ. Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat Toxicological Sciences. 28: 100-110. DOI: 10.1093/toxsci/28.1.100  0.34
1994 Crofton KM, Zhao X. Mid-frequency hearing loss in rats following inhalation exposure to trichloroethylene: evidence from reflex modification audiometry. Neurotoxicology and Teratology. 15: 413-23. PMID 8302243 DOI: 10.1016/0892-0362(93)90059-W  0.391
1994 Sheets LP, Doherty JD, Law MW, Reiter LW, Crofton KM. Age-dependent differences in the susceptibility of rats to deltamethrin Toxicology and Applied Pharmacology. 126: 186-190. PMID 8184428 DOI: 10.1006/Taap.1994.1106  0.398
1994 Bushnell PJ, Kelly KL, Crofton KM. Effects of toluene inhalation on detection of auditory signals in rats. Neurotoxicology and Teratology. 16: 149-60. PMID 8052189 DOI: 10.1016/0892-0362(94)90112-0  0.382
1994 Crofton KM, Lassiter TL, Rebert CS. Solvent-induced ototoxicity in rats: an atypical selective mid-frequency hearing deficit. Hearing Research. 80: 25-30. PMID 7852200 DOI: 10.1016/0378-5955(94)90005-1  0.36
1993 Crofton KM, Peele DB, Stanton ME. Developmental neurotoxicity following neonatal exposure to 3,3'-iminodipropionitrile in the rat. Neurotoxicology and Teratology. 15: 117-29. PMID 8510606 DOI: 10.1016/0892-0362(93)90070-5  0.403
1993 Llorens J, Crofton KM, Tilson HA, Ali SF, Mundy WR. Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 20: 163-9. PMID 8449387 DOI: 10.1006/Faat.1993.1022  0.418
1993 Goldey ES, Kehn LS, Crofton KM. The sensitivity to 3,3'-iminodipropionitrile differs for high- and midfrequency hearing loss in the developing rat. Hearing Research. 69: 221-8. PMID 8226343 DOI: 10.1016/0378-5955(93)90111-D  0.382
1993 Stanton ME, Crofton KM, Lau C. Behavioral development following daily episodes of mother-infant separation in the rat. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 19: 474-7. PMID 1459377 DOI: 10.1016/0272-0590(92)90186-L  0.371
1993 Llorens J, Crofton KM, Tilson HA, Ali SF, Mundy WR. Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure Toxicological Sciences. 20: 163-169. DOI: 10.1093/toxsci/20.2.163  0.308
1991 Crofton KM. Reflex modification and the detection of toxicant-induced auditory dysfunction. Neurotoxicology and Teratology. 12: 461-8. PMID 2247033 DOI: 10.1016/0892-0362(90)90008-Z  0.332
1991 Crofton KM, Dean KF, Hamrick RC, Boyes WK. The effects of 2,4-dithiobiuret on sensory and motor function. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 16: 469-81. PMID 1906822 DOI: 10.1016/0272-0590(91)90087-K  0.357
1991 Crofton KM, Knight T. Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat Neurotoxicology and Teratology. 13: 575-581. PMID 1779945 DOI: 10.1016/0892-0362(91)90040-4  0.374
1990 Crofton KM, Dean KF, Ménache MG, Janssen R. Trimethyltin effects on auditory function and cochlear morphology. Toxicology and Applied Pharmacology. 105: 123-32. PMID 2392800 DOI: 10.1016/0041-008X(90)90364-Z  0.301
1990 Walker QD, Lewis MH, Crofton KM, Mailman RB. Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats. Toxicology and Applied Pharmacology. 102: 474-85. PMID 2315916 DOI: 10.1016/0041-008X(90)90043-T  0.328
1990 Peele DB, Allison SD, Crofton KM. Learning and memory deficits in rats following exposure to 3,3′-iminodipropionitrile Toxicology and Applied Pharmacology. 105: 321-332. PMID 2219122 DOI: 10.1016/0041-008X(90)90193-X  0.335
1990 Crofton KM, Dean KF, Sheets LP, Peele DB. Evidence for an involvement of associative conditioning in reflex modification of the acoustic startle response with gaps in background noise Psychobiology. 18: 467-474. DOI: 10.3758/Bf03333095  0.306
1989 Crofton KM, Dean KF, Boncek VM, Rosen MB, Sheets LP, Chernoff N, Reiter LW. Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: Postnatal evaluation of teratology and behavior Toxicology and Applied Pharmacology. 97: 113-123. PMID 2916230 DOI: 10.1016/0041-008X(89)90060-4  0.433
1989 Crofton KM, Boncek VM, MacPhail RC. Evidence for monoaminergic involvement in triadimefon-induced hyperactivity. Psychopharmacology. 97: 326-330. PMID 2497480 DOI: 10.1007/Bf00439445  0.334
1989 Crofton KM, Sheets LP. Evaluation of Sensory System Function Using Reflex Modification of the Startle Response Journal of the American College of Toxicology. 8: 199-211. DOI: 10.3109/10915818909009105  0.313
1989 Crofton KM, Boncek VM, Reiter LW. Acute effects of amitraz on the acoustic startle response and motor activity Pesticide Science. 27: 1-11. DOI: 10.1002/Ps.2780270102  0.342
1988 Peele DB, Crofton KM. Pyrethroid effects on schedule-controlled behavior: time and dosage relationships. Neurotoxicology and Teratology. 9: 387-94. PMID 3696110 DOI: 10.1016/0892-0362(87)90035-3  0.337
1988 Crofton KM, Reiter LW. The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 10: 624-34. PMID 3396790 DOI: 10.1016/0272-0590(88)90189-3  0.332
1988 Crofton KM, Boncek VM, Reiter LW. Hyperactivity induced by triadimefon, a triazole fungicide. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 10: 459-65. PMID 3371585 DOI: 10.1016/0272-0590(88)90292-8  0.405
1987 Rosen MB, Crofton KM, Chernoff N. Postnatal evaluation of prenatal exposure to p-xylene in the rat. Toxicology Letters. 34: 223-9. PMID 3798481 DOI: 10.1016/0378-4274(86)90214-6  0.324
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