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Vedagopuram Sreekanth - Publications

Affiliations: 
Broad Institute of MIT and Harvard, USA 
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.). 383: eadk4422. PMID 38484051 DOI: 10.1126/science.adk4422  0.751
2023 Nguyen TM, Sreekanth V, Deb A, Kokkonda P, Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature Chemistry. PMID 38110475 DOI: 10.1038/s41557-023-01379-8  0.715
2023 Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Sreekanth V, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metabolism. PMID 37075753 DOI: 10.1016/j.cmet.2023.03.018  0.723
2023 Arp CJ, Reynders M, Sreekanth V, Kokkonda P, Pagano M, Choudhary A, Trauner D. Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. Biorxiv : the Preprint Server For Biology. PMID 37066279 DOI: 10.1101/2023.04.09.536172  0.768
2023 Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann ME, Sherwood RI, et al. A molecular glue approach to control the half-life of CRISPR-based technologies. Biorxiv : the Preprint Server For Biology. PMID 36945568 DOI: 10.1101/2023.03.12.531757  0.736
2023 Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Sreekanth V, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Biorxiv : the Preprint Server For Biology. PMID 36865221 DOI: 10.1101/2023.02.19.529127  0.727
2022 Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nature Cell Biology. PMID 36396978 DOI: 10.1038/s41556-022-01005-8  0.616
2021 Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends in Pharmacological Sciences. PMID 34952739 DOI: 10.1016/j.tips.2021.10.012  0.77
2021 Sreekanth V, Pal S, Kumar S, Komalla V, Yadav P, Shyam R, Sengupta S, Bajaj A. Self-assembled supramolecular nanomicelles from a bile acid-docetaxel conjugate are highly tolerable with improved therapeutic efficacy. Biomaterials Science. PMID 34254078 DOI: 10.1039/d1bm00031d  0.479
2020 Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. Acs Central Science. 6: 2228-2237. PMID 33376784 DOI: 10.1021/acscentsci.0c00129  0.676
2020 Sreekanth V, Kar A, Kumar S, Pal S, Yadav P, Sharma Y, Komalla V, Sharma H, Shyam R, Sharma RD, Mukhopadhyay A, Sengupta S, Dasgupta U, Bajaj A. Bile Acid Tethered Docetaxel-based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes. Angewandte Chemie (International Ed. in English). PMID 33258265 DOI: 10.1002/anie.202015173  0.479
2020 Yang K, Lee M, Jones PA, Liu SS, Zhou A, Xu J, Sreekanth V, Wu JLY, Vo L, Lee EA, Pop R, Lee Y, Wagner BK, Melton DA, Choudhary A, et al. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Science Advances. 6. PMID 33208361 DOI: 10.1126/sciadv.abc3207  0.684
2020 Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, Karp JM, Choudhary A. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nature Communications. 11: 4043. PMID 32792475 DOI: 10.1038/S41467-020-17725-0  0.768
2019 Sreekanth V, Bajaj A. Recent Advances in Engineering of Lipid Drug Conjugates for Cancer Therapy. Acs Biomaterials Science & Engineering. 5: 4148-4166. PMID 33417775 DOI: 10.1021/acsbiomaterials.9b00689  0.518
2019 Sreekanth V, Bajaj A. Recent Advances in Engineering of Lipid Drug Conjugates for Cancer Therapy Acs Biomaterials Science & Engineering. 5: 4148-4166. DOI: 10.1021/Acsbiomaterials.9B00689  0.562
2017 Sreekanth V, Medatwal N, Kumar S, Pal S, Malyla V, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A. Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity. Bioconjugate Chemistry. PMID 29083862 DOI: 10.1021/Acs.Bioconjchem.7B00564  0.554
2017 Sreekanth V, Medatwal N, Pal S, Kumar S, Sengupta S, Bajaj A. Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability. Molecular Pharmaceutics. PMID 28665132 DOI: 10.1021/Acs.Molpharmaceut.7B00105  0.546
2015 Kumar S, Bhargava P, Sreekanth V, Bajaj A. Design, synthesis, and physico-chemical interactions of bile acid derived dimeric phospholipid amphiphiles with model membranes. Journal of Colloid and Interface Science. 448: 398-406. PMID 25746193 DOI: 10.1016/J.Jcis.2015.01.069  0.514
2015 Singh M, Bansal S, Kundu S, Bhargava P, Singh A, Motiani RK, Shyam R, Sreekanth V, Sengupta S, Bajaj A. Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Medchemcomm. 6: 192-201. PMID 25685308 DOI: 10.1039/C4Md00223G  0.528
2015 Yadav K, Bhargava P, Bansal S, Singh M, Gupta S, Sandhu G, Kumar S, Sreekanth V, Bajaj A. Nature of the charged head group dictates the anticancer potential of lithocholic acid-tamoxifen conjugates for breast cancer therapy Medchemcomm. 6: 778-787. DOI: 10.1039/C4Md00289J  0.541
2014 Singh K, Verma V, Yadav K, Sreekanth V, Kumar D, Bajaj A, Kumar V. Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole-quinoline hybrids against cancer and primary endothelial cells. European Journal of Medicinal Chemistry. 87: 150-8. PMID 25247771 DOI: 10.1016/J.Ejmech.2014.09.055  0.518
2014 Singh M, Kundu S, Reddy M A, Sreekanth V, Motiani RK, Sengupta S, Srivastava A, Bajaj A. Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale. 6: 12849-55. PMID 25227567 DOI: 10.1039/C4Nr04064C  0.519
2014 Bhargava P, Singh M, Sreekanth V, Bajaj A. Nature of the charged headgroup determines the fusogenic potential and membrane properties of lithocholic acid phospholipids. The Journal of Physical Chemistry. B. 118: 9341-8. PMID 25029367 DOI: 10.1021/Jp504104A  0.495
2014 Bansal S, Singh M, Kidwai S, Bhargava P, Singh A, Sreekanth V, Singh R, Bajaj A. Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents Medchemcomm. 5: 1761-1768. DOI: 10.1039/C4Md00303A  0.527
2013 Sreekanth V, Bajaj A. Number of free hydroxyl groups on bile acid phospholipids determines the fluidity and hydration of model membranes. The Journal of Physical Chemistry. B. 117: 12135-44. PMID 24079709 DOI: 10.1021/Jp406340Y  0.513
2013 Sreekanth V, Bansal S, Motiani RK, Kundu S, Muppu SK, Majumdar TD, Panjamurthy K, Sengupta S, Bajaj A. Design, synthesis, and mechanistic investigations of bile acid-tamoxifen conjugates for breast cancer therapy. Bioconjugate Chemistry. 24: 1468-84. PMID 23909664 DOI: 10.1021/Bc300664K  0.56
2013 Sreekanth V, Bajaj A. Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid-drug conjugates with model membranes. The Journal of Physical Chemistry. B. 117: 2123-33. PMID 23383746 DOI: 10.1021/Jp3101317  0.514
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