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Sylvain Ladame, Ph.D - Publications

Affiliations: 
2010- Bioengineering Imperial College London, London, England, United Kingdom 
Area:
miRNA, Biosensor development, Nucleic acid biomarkers, Cancer research
Website:
https://ladamebioenglab.weebly.com/dr-ladame.html
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Meng X, O'Hare D, Ladame S. Surface immobilization strategies for the development of electrochemical nucleic acid sensors. Biosensors & Bioelectronics. 237: 115440. PMID 37406480 DOI: 10.1016/j.bios.2023.115440  0.618
2020 Gillespie P, Channon RB, Meng X, Islam MN, Ladame S, O'Hare D. Nucleic acid sensing via electrochemical oligonucleotide-templated reactions. Biosensors & Bioelectronics. 112891. PMID 33397596 DOI: 10.1016/j.bios.2020.112891  0.713
2019 Pavagada S, Channon RB, Chang JYH, Kim SH, MacIntyre D, Bennett PR, Terzidou V, Ladame S. Correction: Oligonucleotide-templated lateral flow assays for amplification-free sensing of circulating microRNAs. Chemical Communications (Cambridge, England). PMID 31647076 DOI: 10.1039/c9cc90472g  0.729
2019 Pavagada S, Channon RB, Chang JYH, Kim SH, MacIntyre D, Bennett PR, Terzidou V, Ladame S. Oligonucleotide-templated lateral flow assays for amplification-free sensing of circulating microRNAs. Chemical Communications (Cambridge, England). PMID 31556888 DOI: 10.1039/C9Cc05607F  0.748
2019 Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S. Hydrogel-Coated Microneedle Arrays for Minimally-Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid. Acs Nano. PMID 31411871 DOI: 10.1021/Acsnano.9B04783  0.537
2018 Pavagada S, Ladame S. Platforms for Bioorthogonal Oligonucleotide-templated Reactions: Translating Concepts into Devices. Chimia. 72: 809-814. PMID 30514424 DOI: 10.2533/Chimia.2018.809  0.416
2018 Gillespie P, Ladame S, O'Hare D. Molecular methods in electrochemical microRNA detection. The Analyst. 144: 114-129. PMID 30375585 DOI: 10.1039/C8An01572D  0.638
2018 Al Sulaiman D, Cadinu P, Ivanov AP, Edel JB, Ladame S. Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing. Nano Letters. PMID 30105906 DOI: 10.1021/Acs.Nanolett.8B03111  0.379
2017 Cadinu P, Paulose Nadappuram B, Lee D, Sze JYY, Campolo G, Zhang Y, Shevchuk A, Ladame S, Albrecht T, Korchev YE, Ivanov AP, Edel JB. Single Molecule Trapping and Sensing using Dual Nanopores separated by a Zeptolitre Nanobridge. Nano Letters. PMID 28862004 DOI: 10.1021/Acs.Nanolett.7B03196  0.316
2017 Al Sulaiman D, Chang JY, Ladame S. Subnanomolar Detection of Oligonucleotides through Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity. Angewandte Chemie (International Ed. in English). PMID 28382640 DOI: 10.1002/Anie.201701356  0.592
2017 Zuffo M, Ladame S, Doria F, Freccero M. Tuneable coumarin-NDI dyads as G-quadruplex specific light-up probes Sensors and Actuators B: Chemical. 245: 780-788. DOI: 10.1016/J.Snb.2017.01.144  0.329
2016 Metcalf GA, Shibakawa A, Patel H, Sita-Lumsden A, Zivi A, Rama N, Bevan CL, Ladame S. Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer Diagnosis. Analytical Chemistry. PMID 27498854 DOI: 10.1021/Acs.Analchem.6B01594  0.42
2016 Panich S, Haj Sleiman M, Steer I, Ladame S, Edel JB. Real-Time Monitoring of Ligand Binding to G-Quadruplex and Duplex DNA by Whispering Gallery Mode Sensing Acs Sensors. 1: 1097-1102. DOI: 10.1021/Acssensors.6B00301  0.399
2015 Zuffo M, Doria F, Spalluto V, Ladame S, Freccero M. Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 17596-600. PMID 26463116 DOI: 10.1002/Chem.201503020  0.353
2014 Choi Y, Metcalf G, Sleiman MH, Vair-Turnbull D, Ladame S. Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: concept and biomedical applications. Bioorganic & Medicinal Chemistry. 22: 4395-8. PMID 24957880 DOI: 10.1016/J.Bmc.2014.05.071  0.42
2014 Sleiman MH, Ladame S. Synthesis of squaraine dyes under mild conditions: Applications for labelling and sensing of biomolecules Chemical Communications. 50: 5288-5290. PMID 24402188 DOI: 10.1039/C3Cc47894G  0.323
2013 Najah M, Mayot E, Mahendra-Wijaya IP, Griffiths AD, Ladame S, Drevelle A. New glycosidase substrates for droplet-based microfluidic screening. Analytical Chemistry. 85: 9807-14. PMID 24079367 DOI: 10.1021/Ac4022709  0.303
2013 Percivalle C, Bartolo JF, Ladame S. Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process. Organic & Biomolecular Chemistry. 11: 16-26. PMID 23076879 DOI: 10.1039/C2Ob26163D  0.325
2013 Percivalle C, Mahmood T, Ladame S. Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters Medchemcomm. 4: 211-215. DOI: 10.1039/C2Md20173A  0.315
2012 Meguellati K, Ladame S. Reversible covalent chemistries compatible with the principles of constitutional dynamic chemistry: new reactions to create more diversity. Topics in Current Chemistry. 322: 291-314. PMID 22025070 DOI: 10.1007/128_2011_277  0.325
2010 Koripelly G, Meguellati K, Ladame S. Dual sensing of hairpin and quadruplex DNA structures using multicolored peptide nucleic acid fluorescent probes. Bioconjugate Chemistry. 21: 2103-9. PMID 20923172 DOI: 10.1021/Bc100335F  0.429
2010 Meguellati K, Spichty M, Ladame S. Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts. Molecular Biosystems. 6: 1694-9. PMID 20473419 DOI: 10.1039/C002157A  0.318
2010 Meguellati K, Koripelly G, Ladame S. DNA-templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G-quadruplex formation. Angewandte Chemie (International Ed. in English). 49: 2738-42. PMID 20229556 DOI: 10.1002/Anie.201000291  0.423
2010 Mahmood T, Paul A, Ladame S. Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes. The Journal of Organic Chemistry. 75: 204-7. PMID 19954141 DOI: 10.1021/Jo901820T  0.342
2009 Redman JE, Granadino-Roldán JM, Schouten JA, Ladame S, Reszka AP, Neidle S, Balasubramanian S. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Organic & Biomolecular Chemistry. 7: 76-84. PMID 19081949 DOI: 10.1039/B814682A  0.652
2008 Paul A, Sengupta P, Krishnan Y, Ladame S. Combining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3+1) PNA-DNA bimolecular quadruplex. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 8682-9. PMID 18668497 DOI: 10.1002/Chem.200800605  0.656
2008 Soldatenkov VA, Vetcher AA, Duka T, Ladame S. First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1. Acs Chemical Biology. 3: 214-9. PMID 18338862 DOI: 10.1021/Cb700234F  0.369
2008 Ladame S. Dynamic combinatorial chemistry: on the road to fulfilling the promise. Organic & Biomolecular Chemistry. 6: 219-26. PMID 18174988 DOI: 10.1039/B714599C  0.34
2007 Shirude PS, Gillies ER, Ladame S, Godde F, Shin-Ya K, Huc I, Balasubramanian S. Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. Journal of the American Chemical Society. 129: 11890-1. PMID 17845042 DOI: 10.1021/Ja073775H  0.52
2006 Redman JE, Ladame S, Reszka AP, Neidle S, Balasubramanian S. Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library. Organic & Biomolecular Chemistry. 4: 4364-9. PMID 17102882 DOI: 10.1039/B611716C  0.633
2006 Jantos K, Rodriguez R, Ladame S, Shirude PS, Balasubramanian S. Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands. Journal of the American Chemical Society. 128: 13662-3. PMID 17044674 DOI: 10.1021/Ja064713E  0.553
2006 Gonçalves DP, Ladame S, Balasubramanian S, Sanders JK. Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins. Organic & Biomolecular Chemistry. 4: 3337-42. PMID 17036123 DOI: 10.1039/B608494J  0.531
2006 Green JJ, Ladame S, Ying L, Klenerman D, Balasubramanian S. Investigating a quadruplex-ligand interaction by unfolding kinetics. Journal of the American Chemical Society. 128: 9809-12. PMID 16866537 DOI: 10.1021/Ja0615425  0.524
2006 Fernando H, Reszka AP, Huppert J, Ladame S, Rankin S, Venkitaraman AR, Neidle S, Balasubramanian S. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry. 45: 7854-60. PMID 16784237 DOI: 10.1021/Bi0601510  0.499
2006 Ladame S, Schouten JA, Roldan J, Redman JE, Neidle S, Balasubramanian S. Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry. 45: 1393-9. PMID 16445281 DOI: 10.1021/Bi050229X  0.63
2005 Ladame S, Whitney AM, Balasubramanian S. Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach. Angewandte Chemie (International Ed. in English). 44: 5736-9. PMID 16078284 DOI: 10.1002/Anie.200501450  0.54
2005 Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle S. Putative DNA quadruplex formation within the human c-kit oncogene. Journal of the American Chemical Society. 127: 10584-9. PMID 16045346 DOI: 10.1021/Ja050823U  0.504
2004 Patel SD, Isalan M, Gavory G, Ladame S, Choo Y, Balasubramanian S. Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes. Biochemistry. 43: 13452-8. PMID 15491152 DOI: 10.1021/Bi048892T  0.54
2004 Ladame S, Schouten JA, Stuart J, Roldan J, Neidle S, Balasubramanian S. Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Organic & Biomolecular Chemistry. 2: 2925-31. PMID 15480456 DOI: 10.1039/B409698C  0.57
2004 Whitney AM, Ladame S, Balasubramanian S. Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry. Angewandte Chemie (International Ed. in English). 43: 1143-6. PMID 14983458 DOI: 10.1002/Anie.200353069  0.56
2003 Ladame S, Castilho MS, Silva CH, Denier C, Hannaert V, Périé J, Oliva G, Willson M. Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-d-glyceric acid. European Journal of Biochemistry / Febs. 270: 4574-86. PMID 14622286 DOI: 10.1046/J.1432-1033.2003.03857.X  0.628
2003 Castilho MS, Pavão F, Oliva G, Ladame S, Willson M, Périé J. Evidence for the two phosphate binding sites of an analogue of the thioacyl intermediate for the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction, from its crystal structure. Biochemistry. 42: 7143-51. PMID 12795610 DOI: 10.1021/Bi0206107  0.646
2003 Schouten JA, Ladame S, Mason SJ, Cooper MA, Balasubramanian S. G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection. Journal of the American Chemical Society. 125: 5594-5. PMID 12733873 DOI: 10.1021/Ja029356W  0.679
2002 Ladame S, Harrison RJ, Neidle S, Balasubramanian S. Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates. Organic Letters. 4: 2509-12. PMID 12123363 DOI: 10.1021/Ol026130P  0.527
2002 Ladame S, Willson M, Périé J. A Convenient Synthesis of Dibenzyl α,α-Difluoromethyl-β-ketophosphonates European Journal of Organic Chemistry. 2002: 2640. DOI: 10.1002/1099-0690(200208)2002:15<2640::Aid-Ejoc2640>3.0.Co;2-9  0.577
2001 Ladame S, Bardet M, Périé J, Willson M. Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues. Bioorganic & Medicinal Chemistry. 9: 773-83. PMID 11310612 DOI: 10.1016/S0968-0896(00)00295-9  0.596
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