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Stephane A Laporte - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
GPCR
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62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sarma P, Carino CMC, Seetharama D, Pandey S, Dwivedi-Agnihotri H, Rui X, Cao Y, Kawakami K, Kumari P, Chen YC, Luker KE, Yadav PN, Luker GD, Laporte SA, Chen X, et al. Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system. Nature Communications. 14: 4808. PMID 37558722 DOI: 10.1038/s41467-023-40482-9  0.535
2023 Cao Y, van der Velden WJC, Namkung Y, Nivedha AK, Cho A, Sedki D, Holleran B, Lee N, Leduc R, Muk S, Le K, Bhattacharya S, Vaidehi N, Laporte SA. Unraveling allostery within the angiotensin II type 1 receptor for Gα and β-arrestin coupling. Science Signaling. 16: eadf2173. PMID 37552769 DOI: 10.1126/scisignal.adf2173  0.474
2022 Sandhu M, Cho A, Ma N, Mukhaleva E, Namkung Y, Lee S, Ghosh S, Lee JH, Gloriam DE, Laporte SA, Babu MM, Vaidehi N. Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity. Nature Communications. 13: 7428. PMID 36460632 DOI: 10.1038/s41467-022-34055-5  0.325
2022 Baidya M, Chaturvedi M, Dwivedi-Agnihotri H, Ranjan A, Devost D, Namkung Y, Stepniewski TM, Pandey S, Baruah M, Panigrahi B, Sarma P, Yadav MK, Maharana J, Banerjee R, Kawakami K, ... ... Laporte SA, et al. Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody. Nature Communications. 13: 4634. PMID 35941121 DOI: 10.1038/s41467-022-32386-x  0.461
2022 Sedki D, Cho A, Cao Y, Nikolajev L, Atmuri NDP, Lubell WD, Laporte SA. Prostaglandin F2α and angiotensin II type 1 receptors exhibit differential cognate G protein coupling regulation. The Journal of Biological Chemistry. 102294. PMID 35872018 DOI: 10.1016/j.jbc.2022.102294  0.496
2021 Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Maharana J, Ranjan A, Chaturvedi M, Jhingan GD, ... Laporte SA, et al. Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell. PMID 34582793 DOI: 10.1016/j.molcel.2021.09.007  0.495
2021 Free RB, Cuoco CA, Xie B, Namkung Y, Prabhu VV, Willette BKA, Day MM, Sanchez-Soto M, Lane JR, Laporte SA, Shi L, Allen JE, Sibley DR. Pharmacological characterization of the imipridone anti-cancer drug ONC201 reveals a negative allosteric mechanism of action at the D dopamine receptor. Molecular Pharmacology. PMID 34353882 DOI: 10.1124/molpharm.121.000336  0.36
2021 Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, ... ... Laporte SA, et al. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nature Communications. 12: 4688. PMID 34344896 DOI: 10.1038/s41467-021-24968-y  0.444
2020 Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Chaturvedi M, Stepniewski TM, Kawakami K, Cao Y, Laporte SA, Selent J, Inoue A, Shukla AK. Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation. Embo Reports. e49886. PMID 32715625 DOI: 10.15252/Embr.201949886  0.413
2020 Cao Y, Kumar S, Namkung Y, Gagnon L, Cho A, Laporte SA. Angiotensin II type 1 receptor variants alter endosomal receptor-β-arrestin complex stability and MAPK activation. The Journal of Biological Chemistry. PMID 32703898 DOI: 10.1074/jbc.RA120.014330  0.397
2019 Gagnon L, Cao Y, Cho A, Sedki D, Huber T, Sakmar TP, Laporte SA. Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor. The Journal of Biological Chemistry. PMID 31530642 DOI: 10.1074/Jbc.Ra119.010324  0.379
2019 Cao Y, Namkung Y, Laporte SA. Methods to Monitor the Trafficking of β-Arrestin/G Protein-Coupled Receptor Complexes Using Enhanced Bystander BRET. Methods in Molecular Biology (Clifton, N.J.). 1957: 59-68. PMID 30919346 DOI: 10.1007/978-1-4939-9158-7_3  0.434
2018 Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. FZD is a Gα-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science Signaling. 11. PMID 30514810 DOI: 10.1126/Scisignal.Aar5536  0.495
2018 Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, ... Laporte SA, et al. Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors. Science Signaling. 11. PMID 30514808 DOI: 10.1126/Scisignal.Aat1631  0.443
2018 Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, ... ... Laporte SA, et al. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11. PMID 30254056 DOI: 10.1126/Scisignal.Aat7650  0.576
2018 Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the DDopamine Receptor. Frontiers in Synaptic Neuroscience. 10: 2. PMID 29515433 DOI: 10.3389/Fnsyn.2018.00002  0.344
2017 Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nature Communications. 8: 15054. PMID 28416805 DOI: 10.1038/Ncomms15054  0.355
2016 Namkung Y, Le Gouill C, Lukashova V, Kobayashi H, Hogue M, Khoury E, Song M, Bouvier M, Laporte SA. Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET. Nature Communications. 7: 12178. PMID 27397672 DOI: 10.1038/Ncomms12178  0.424
2016 Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, et al. Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071102 DOI: 10.1073/Pnas.1521706113  0.397
2016 Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM. The conformational signature of β-arrestin2 predicts its trafficking and signalling functions. Nature. PMID 27007854 DOI: 10.1038/Nature17154  0.408
2015 Charles R, Namkung Y, Cotton M, Laporte SA, Claing A. βarrestin-Mediated Angiotensin II Signaling Controls the Activation of ARF6 and Endocytosis in Migration of Vascular Smooth Muscle Cells. The Journal of Biological Chemistry. PMID 26703465 DOI: 10.1074/Jbc.M115.684357  0.374
2015 Boukanoun MK, Hou X, Nikolajev L, Ratni S, Olson D, Claing A, Laporte SA, Chemtob S, Lubell WD. Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor. Organic & Biomolecular Chemistry. PMID 26090777 DOI: 10.1039/C5Ob00962F  0.323
2015 Namkung Y, Radresa O, Armando S, Devost D, Beautrait A, Le Gouill C, Laporte SA. Quantifying biased signaling in GPCRs using BRET-based biosensors. Methods (San Diego, Calif.). PMID 25890247 DOI: 10.1016/j.ymeth.2015.04.010  0.346
2015 Goupil E, Fillion D, Clément S, Luo X, Devost D, Sleno R, Pétrin D, Saragovi HU, Thorin É, Laporte SA, Hébert TE. Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells. The Journal of Biological Chemistry. 290: 3137-48. PMID 25512374 DOI: 10.1074/Jbc.M114.631119  0.447
2014 Khoury E, Nikolajev L, Simaan M, Namkung Y, Laporte SA. Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK. The Journal of Biological Chemistry. 289: 23302-17. PMID 25016018 DOI: 10.1074/jbc.M114.568147  0.329
2014 Khoury E, Clément S, Laporte SA. Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics. Frontiers in Endocrinology. 5: 68. PMID 24847311 DOI: 10.3389/fendo.2014.00068  0.437
2013 Goupil E, Laporte SA, Hébert TE. A simple method to detect allostery in GPCR dimers. Methods in Cell Biology. 117: 165-79. PMID 24143977 DOI: 10.1016/B978-0-12-408143-7.00009-8  0.412
2013 Goupil E, Laporte SA, Hébert TE. GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery. British Journal of Pharmacology. 168: 1101-3. PMID 23121476 DOI: 10.1111/Bph.12040  0.438
2012 Goupil E, Wisehart V, Khoury E, Zimmerman B, Jaffal S, Hébert TE, Laporte SA. Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK. Molecular Endocrinology (Baltimore, Md.). 26: 1189-202. PMID 22638073 DOI: 10.1210/Me.2011-1245  0.483
2012 Zimmerman B, Beautrait A, Aguila B, Charles R, Escher E, Claing A, Bouvier M, Laporte SA. Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs. Science Signaling. 5: ra33. PMID 22534132 DOI: 10.1126/Scisignal.2002522  0.404
2012 Wrzal PK, Goupil E, Laporte SA, Hébert TE, Zingg HH. Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells. Cellular Signalling. 24: 333-41. PMID 21964067 DOI: 10.1016/J.Cellsig.2011.09.019  0.401
2012 Wrzal PK, Devost D, Pétrin D, Goupil E, Iorio-Morin C, Laporte SA, Zingg HH, Hébert TE. Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization. Cellular Signalling. 24: 342-50. PMID 21963428 DOI: 10.1016/J.Cellsig.2011.09.020  0.366
2011 Aguila B, Simaan M, Laporte SA. Study of G protein-coupled receptor/β-arrestin interactions within endosomes using FRAP. Methods in Molecular Biology (Clifton, N.J.). 756: 371-80. PMID 21870240 DOI: 10.1007/978-1-61779-160-4_23  0.325
2011 Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD. Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. Journal of Medicinal Chemistry. 54: 6085-97. PMID 21774512 DOI: 10.1021/Jm200608K  0.35
2011 Zimmerman B, Simaan M, Akoume MY, Houri N, Chevallier S, Séguéla P, Laporte SA. Role of ßarrestins in bradykinin B2 receptor-mediated signalling. Cellular Signalling. 23: 648-59. PMID 21145390 DOI: 10.1016/j.cellsig.2010.11.016  0.605
2011 Mathurin K, Gallant MA, Germain P, Allard-Chamard H, Brisson J, Iorio-Morin C, de Brum Fernandes A, Caron MG, Laporte SA, Parent JL. An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. The Journal of Biological Chemistry. 286: 2696-706. PMID 21112970 DOI: 10.1074/Jbc.M110.178277  0.366
2010 Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, ... Laporte SA, et al. A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. The Journal of Biological Chemistry. 285: 25624-36. PMID 20551320 DOI: 10.1074/Jbc.M110.115196  0.447
2010 Posner BI, Laporte SA. Cellular signalling: Peptide hormones and growth factors. Progress in Brain Research. 181: 1-16. PMID 20478429 DOI: 10.1016/S0079-6123(08)81001-1  0.442
2010 Robitaille M, Gora S, Wang Y, Goupil E, Pétrin D, Del Duca D, Villeneuve LR, Allen BG, Laporte SA, Bernard DJ, Hébert TE. Gbetagamma is a negative regulator of AP-1 mediated transcription. Cellular Signalling. 22: 1254-66. PMID 20403427 DOI: 10.1016/J.Cellsig.2010.04.005  0.359
2009 Cui W, Simaan M, Laporte S, Lodge R, Cianflone K. C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. Molecular Immunology. 46: 3086-98. PMID 19615750 DOI: 10.1016/J.Molimm.2009.06.007  0.333
2009 Guo J, Chen H, Ho J, Mancini J, Sontag T, Laporte SA, Richard DE, Lebrun JJ. TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration. Cellular Signalling. 21: 899-905. PMID 19385060 DOI: 10.1016/j.cellsig.2009.01.037  0.375
2009 Zimmerman B, Simaan M, Lee MH, Luttrell LM, Laporte SA. c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cellular Signalling. 21: 103-10. PMID 18938240 DOI: 10.1016/j.cellsig.2008.09.013  0.574
2007 Gousseva V, Simaan M, Laporte SA, Swain PS. Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching. Biophysical Journal. 94: 679-87. PMID 17827242 DOI: 10.1529/biophysj.107.115188  0.524
2007 Poupart ME, Fessart D, Cotton M, Laporte SA, Claing A. ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. Cellular Signalling. 19: 2370-8. PMID 17719203 DOI: 10.1016/J.Cellsig.2007.07.015  0.569
2007 Hamdan FF, Rochdi MD, Breton B, Fessart D, Michaud DE, Charest PG, Laporte SA, Bouvier M. Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2. The Journal of Biological Chemistry. 282: 29089-100. PMID 17675294 DOI: 10.1074/Jbc.M700577200  0.553
2007 Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan FF, Wiseman PW, Bouvier M, Laporte SA. Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. Journal of Cell Science. 120: 1723-32. PMID 17456551 DOI: 10.1242/Jcs.03444  0.522
2007 Marion S, Fralish GB, Laporte S, Caron MG, Barak LS. N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins. The Journal of Biological Chemistry. 282: 18937-44. PMID 17456469 DOI: 10.1074/jbc.M700090200  0.609
2005 Claing A, Laporte SA. Novel roles for arrestins in G protein-coupled receptor biology and drug discovery. Current Opinion in Drug Discovery & Development. 8: 585-9. PMID 16159020  0.578
2005 Ho J, Cocolakis E, Dumas VM, Posner BI, Laporte SA, Lebrun JJ. The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction. The Embo Journal. 24: 3247-58. PMID 16121194 DOI: 10.1038/sj.emboj.7600794  0.484
2005 Simaan M, Bédard-Goulet S, Fessart D, Gratton JP, Laporte SA. Dissociation of beta-arrestin from internalized bradykinin B2 receptor is necessary for receptor recycling and resensitization. Cellular Signalling. 17: 1074-83. PMID 15993749 DOI: 10.1016/J.Cellsig.2004.12.001  0.658
2005 Laroche G, Rochdi MD, Laporte SA, Parent JL. Involvement of actin in agonist-induced endocytosis of the G protein-coupled receptor for thromboxane A2: overcoming of actin disruption by arrestin-3 but not arrestin-2. The Journal of Biological Chemistry. 280: 23215-24. PMID 15845539 DOI: 10.1074/jbc.M414071200  0.45
2005 Kim KM, Gainetdinov RR, Laporte SA, Caron MG, Barak LS. G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. The Journal of Biological Chemistry. 280: 12774-80. PMID 15687500 DOI: 10.1074/jbc.M408901200  0.684
2005 Proulx CD, Simaan M, Escher E, Laporte SA, Guillemette G, Leduc R. Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization. The Biochemical Journal. 385: 115-23. PMID 15458389 DOI: 10.1042/Bj20040807  0.63
2004 Fessart D, Simaan M, Laporte SA. c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Molecular Endocrinology (Baltimore, Md.). 19: 491-503. PMID 15498833 DOI: 10.1210/me.2004-0246  0.526
2004 Hasbi A, Devost D, Laporte SA, Zingg HH. Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2. Molecular Endocrinology (Baltimore, Md.). 18: 1277-86. PMID 14976224 DOI: 10.1210/Me.2003-0440  0.591
2003 Zingg HH, Laporte SA. The oxytocin receptor. Trends in Endocrinology and Metabolism: Tem. 14: 222-7. PMID 12826328 DOI: 10.1016/S1043-2760(03)00080-8  0.533
2003 Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. The Journal of Biological Chemistry. 278: 6258-67. PMID 12473660 DOI: 10.1074/jbc.M212231200  0.705
2002 Wilbanks AM, Laporte SA, Bohn LM, Barak LS, Caron MG. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry. 41: 11981-9. PMID 12356298 DOI: 10.1021/Bi020275M  0.449
2002 Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman HA. Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. The Journal of Cell Biology. 158: 563-75. PMID 12163475 DOI: 10.1083/Jcb.200202113  0.675
2002 Claing A, Laporte SA, Caron MG, Lefkowitz RJ. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Progress in Neurobiology. 66: 61-79. PMID 11900882 DOI: 10.1016/S0301-0082(01)00023-5  0.695
2002 Laporte SA, Miller WE, Kim KM, Caron MG. beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. The Journal of Biological Chemistry. 277: 9247-54. PMID 11777907 DOI: 10.1074/Jbc.M108490200  0.606
2002 Seachrist JL, Laporte SA, Dale LB, Babwah AV, Caron MG, Anborgh PH, Ferguson SS. Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. The Journal of Biological Chemistry. 277: 679-85. PMID 11682489 DOI: 10.1074/Jbc.M109022200  0.601
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