| Year |
Citation |
Score |
| 2024 |
Jack CE, Cope EM, Lemel L, Canals M, Drube J, Hoffmann C, Inoue A, Hislop JN, Thompson D. GRK5 regulates endocytosis of FPR2 independent of β-Arrestins. The Journal of Biological Chemistry. 108112. PMID 39706266 DOI: 10.1016/j.jbc.2024.108112 |
0.4 |
|
| 2024 |
Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, et al. Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies. Biorxiv : the Preprint Server For Biology. PMID 39574661 DOI: 10.1101/2024.11.04.621790 |
0.704 |
|
| 2024 |
Matthees ESF, Hoffmann C. The Ca-sensing receptor and the pocketome: comparing nature's complexity with human intervention in receptor modulation. Signal Transduction and Targeted Therapy. 9: 173. PMID 39004651 DOI: 10.1038/s41392-024-01863-8 |
0.344 |
|
| 2024 |
Matthees ESF, Filor JC, Jaiswal N, Reichel M, Youssef N, D'Uonnolo G, Szpakowska M, Drube J, König GM, Kostenis E, Chevigné A, Godbole A, Hoffmann C. GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism. Communications Biology. 7: 802. PMID 38956302 DOI: 10.1038/s42003-024-06490-1 |
0.529 |
|
| 2024 |
Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S. Rapid elucidation of agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay. European Journal of Pharmacology. 176587. PMID 38642667 DOI: 10.1016/j.ejphar.2024.176587 |
0.361 |
|
| 2024 |
Ay Ü, Leníček M, Haider RS, Classen A, van Eijk H, Koelfat KVK, van der Kroft G, Neumann UP, Hoffmann C, Bolm C, Olde Damink SWM, Schaap FG. Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR. Hepatology Communications. 8. PMID 38517202 DOI: 10.1097/HC9.0000000000000383 |
0.428 |
|
| 2024 |
Zarca A, Adlere I, Viciano CP, Arimont-Segura M, Meyrath M, Simon IA, Bebelman JP, Laan D, Custers HGJ, Janssen E, Versteegh KLK, Buzink M, Nesheva D, Bosma R, de Esch IJP, ... ... Hoffmann C, et al. Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist for the atypical chemokine receptor ACKR3. Molecular Pharmacology. PMID 38346795 DOI: 10.1124/molpharm.123.000835 |
0.63 |
|
| 2023 |
Kostenis E, Gomeza J, Miess-Tanneberg E, Blum NK, Benkel T, Chevigné A, Hoffmann C, Kolb P, Nikolaev V, Waldhoer M, Szpakowska M, Inoue A, Schulz S. Reply to: How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7867. PMID 38036502 DOI: 10.1038/s41467-023-42849-4 |
0.461 |
|
| 2023 |
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, et al. Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. The Journal of Biological Chemistry. 299: 105293. PMID 37774973 DOI: 10.1016/j.jbc.2023.105293 |
0.362 |
|
| 2023 |
Ganguly A, Quon T, Jenkins L, Joseph B, Al-Awar R, Chevigne A, Tobin AB, Uehling DE, Hoffmann C, Drube J, Milligan G. G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions. The Journal of Biological Chemistry. 105218. PMID 37660910 DOI: 10.1016/j.jbc.2023.105218 |
0.502 |
|
| 2023 |
Haider RS, Reichel M, Matthees ESF, Hoffmann C. Conformational flexibility of β-arrestins - How these scaffolding proteins guide and transform the functionality of GPCRs. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2300053. PMID 37259558 DOI: 10.1002/bies.202300053 |
0.442 |
|
| 2023 |
Grimes J, Koszegi Z, Lanoiselée Y, Miljus T, O'Brien SL, Stepniewski TM, Medel-Lacruz B, Baidya M, Makarova M, Mistry R, Goulding J, Drube J, Hoffmann C, Owen DM, Shukla AK, et al. Plasma membrane preassociation drives β-arrestin coupling to receptors and activation. Cell. 186: 2238-2255.e20. PMID 37146613 DOI: 10.1016/j.cell.2023.04.018 |
0.696 |
|
| 2023 |
Heinz CS, Bermudez M, Jaiswal N, Große C, Kauk M, Hoffmann C, Holzgrabe U. Hybridization into a Bitopic Ligand Increased Muscarinic Receptor Activation for Isopilocarpine but Not for Pilocarpine Derivatives. Journal of Natural Products. PMID 37042802 DOI: 10.1021/acs.jnatprod.2c01079 |
0.398 |
|
| 2023 |
Matera C, Kauk M, Cirillo D, Maspero M, Papotto C, Volpato D, Holzgrabe U, De Amici M, Hoffmann C, Dallanoce C. Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation. Molecules (Basel, Switzerland). 28. PMID 36903650 DOI: 10.3390/molecules28052407 |
0.371 |
|
| 2023 |
Gerhards J, Maerz LD, Matthees ESF, Donow C, Moepps B, Premont RT, Burkhalter MD, Hoffmann C, Philipp M. Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. Journal of the American Society of Nephrology : Jasn. PMID 36810260 DOI: 10.1681/ASN.0000000000000082 |
0.42 |
|
| 2022 |
Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, ... ... Hoffmann C, et al. How Carvedilol activates β-adrenoceptors. Nature Communications. 13: 7109. PMID 36402762 DOI: 10.1038/s41467-022-34765-w |
0.706 |
|
| 2022 |
Kaufmann J, Blum NK, Nagel F, Schuler A, Drube J, Degenhart C, Engel J, Eickhoff JE, Dasgupta P, Fritzwanker S, Guastadisegni M, Schulte C, Miess-Tanneberg E, Maric HM, Spetea M, ... ... Hoffmann C, et al. A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening. Communications Biology. 5: 1206. PMID 36352263 DOI: 10.1038/s42003-022-04135-9 |
0.39 |
|
| 2022 |
Haider RS, Matthees ESF, Drube J, Reichel M, Zabel U, Inoue A, Chevigné A, Krasel C, Deupi X, Hoffmann C. β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells. Nature Communications. 13: 5638. PMID 36163356 DOI: 10.1038/s41467-022-33307-8 |
0.372 |
|
| 2022 |
Reichel M, Weitzel V, Klement L, Hoffmann C, Drube J. Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots. International Journal of Molecular Sciences. 23. PMID 35163118 DOI: 10.3390/ijms23031195 |
0.342 |
|
| 2020 |
Volpato D, Kauk M, Messerer R, Bermudez M, Wolber G, Bock A, Hoffmann C, Holzgrabe U. The Role of Orthosteric Building Blocks of Bitopic Ligands for Muscarinic M1 Receptors. Acs Omega. 5: 31706-31715. PMID 33344823 DOI: 10.1021/acsomega.0c04220 |
0.707 |
|
| 2020 |
Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 33148803 DOI: 10.1073/pnas.2013319117 |
0.833 |
|
| 2020 |
Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, ... Hoffmann C, et al. Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling. Acs Pharmacology & Translational Science. 3: 859-867. PMID 33073186 DOI: 10.1021/acsptsci.0c00069 |
0.744 |
|
| 2020 |
Neves M, Perpiñá-Viciano C, Penela P, Hoffmann C, Mayor F. Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2. Acs Pharmacology & Translational Science. 3: 627-634. PMID 33073183 DOI: 10.1021/acsptsci.0c00021 |
0.484 |
|
| 2020 |
Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/Mol.119.118448 |
0.805 |
|
| 2020 |
Butt E, Stempfle K, Lister L, Wolf F, Kraft M, Herrmann AB, Viciano CP, Weber C, Hochhaus A, Ernst T, Hoffmann C, Zernecke A, Frietsch JJ. Phosphorylation-Dependent Differences in CXCR4-LASP1-AKT1 Interaction between Breast Cancer and Chronic Myeloid Leukemia. Cells. 9. PMID 32075106 DOI: 10.3390/Cells9020444 |
0.384 |
|
| 2020 |
Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G. Structural insight into small molecule action on Frizzleds. Nature Communications. 11: 414. PMID 31964872 DOI: 10.1038/S41467-019-14149-3 |
0.468 |
|
| 2019 |
Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M. Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nature Communications. 10: 5784. PMID 31857598 DOI: 10.1038/S41467-019-13722-0 |
0.479 |
|
| 2019 |
Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, ... ... Hoffmann C, et al. Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. Jci Insight. 4. PMID 31619590 DOI: 10.1172/Jci.Insight.121971 |
0.41 |
|
| 2019 |
Mühleder S, Fuchs C, Basílio J, Szwarc D, Pill K, Labuda K, Slezak P, Siehs C, Pröll J, Priglinger E, Hoffmann C, Junger WG, Redl H, Holnthoner W. Purinergic P2Y receptors modulate endothelial sprouting. Cellular and Molecular Life Sciences : Cmls. PMID 31278420 DOI: 10.1007/S00018-019-03213-2 |
0.428 |
|
| 2019 |
Arimont M, Hoffmann C, de Graaf C, Leurs R. Chemokine receptor crystal structures: what can be learnt from them? Molecular Pharmacology. PMID 31266800 DOI: 10.1124/Mol.119.117168 |
0.492 |
|
| 2019 |
Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C. Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3). Molecular Pharmacology. PMID 31092552 DOI: 10.1124/Mol.118.115477 |
0.712 |
|
| 2019 |
Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, ... ... Hoffmann C, et al. Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1. Nature Communications. 10: 1804. PMID 31000703 DOI: 10.1038/S41467-019-09651-7 |
0.358 |
|
| 2018 |
Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. FZD is a Gα-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science Signaling. 11. PMID 30514810 DOI: 10.1126/Scisignal.Aar5536 |
0.601 |
|
| 2018 |
Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano Perpiñá C, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, et al. Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. European Journal of Medicinal Chemistry. 162: 631-649. PMID 30476826 DOI: 10.1016/J.Ejmech.2018.10.060 |
0.647 |
|
| 2018 |
Littmann T, Ozawa T, Hoffmann C, Buschauer A, Bernhardt G. A split luciferase-based probe for quantitative proximal determination of Gα signalling in live cells. Scientific Reports. 8: 17179. PMID 30464299 DOI: 10.1038/S41598-018-35615-W |
0.554 |
|
| 2018 |
Haider RS, Godbole A, Hoffmann C. To sense or not to sense-new insights from GPCR-based and arrestin-based biosensors. Current Opinion in Cell Biology. 57: 16-24. PMID 30408632 DOI: 10.1016/J.Ceb.2018.10.005 |
0.485 |
|
| 2018 |
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, ... ... Hoffmann C, et al. Lack of beta-arrestin signaling in the absence of active G proteins. Nature Communications. 9: 341. PMID 29362459 DOI: 10.1038/S41467-017-02661-3 |
0.549 |
|
| 2018 |
Schreiber B, Kauk M, Heil HS, Emmerling M, Tessmer I, Kamp M, Höfling S, Holzgrabe U, Hoffmann C, Heinze KG. Enhanced Fluorescence Resonance Energy Transfer in G-Protein-Coupled Receptor Probes on Nanocoated Microscopy Coverslips Acs Photonics. 5: 2225-2233. DOI: 10.1021/Acsphotonics.8B00072 |
0.526 |
|
| 2018 |
Schreiber B, Kauk M, Heil H, Hoffmann C, Heinze KG. ‘Forbidden’ States Boost Fluorescence Resonance Energy Transfer (FRET) Studies of Membrane Receptors in Live Cells Biophysical Journal. 114: 165a. DOI: 10.1016/J.Bpj.2017.11.925 |
0.443 |
|
| 2017 |
Kauk M, Hoffmann C. Intramolecular and Intermolecular FRET Sensors for GPCRs - Monitoring Conformational Changes and Beyond. Trends in Pharmacological Sciences. PMID 29180026 DOI: 10.1016/J.Tips.2017.10.011 |
0.456 |
|
| 2017 |
Oehler B, Mohammadi M, Perpina Viciano C, Hackel D, Hoffmann C, Brack A, Rittner HL. Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats. Frontiers in Molecular Neuroscience. 10: 242. PMID 28824373 DOI: 10.3389/Fnmol.2017.00242 |
0.451 |
|
| 2017 |
Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M. A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy. Angewandte Chemie (International Ed. in English). PMID 28510314 DOI: 10.1002/Anie.201701524 |
0.601 |
|
| 2017 |
Messerer R, Kauk M, Volpato D, Alonso Cañizal MC, Kloeckner J, Zabel U, Nuber S, Hoffmann C, Holzgrabe U. FRET Studies of Quinolone-Based Bitopic Ligands and their Structural Analogues at the Muscarinic M1 Receptor. Acs Chemical Biology. PMID 28117571 DOI: 10.1021/Acschembio.6B00828 |
0.552 |
|
| 2017 |
Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M. Ein photoschaltbarer Ligand zur Regulierung der Rezeptoraktivierung Angewandte Chemie. 129: 7388-7393. DOI: 10.1002/Ange.201701524 |
0.304 |
|
| 2016 |
Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL. Functional and structural characterization of axonal opioid receptors as targets for analgesia. Molecular Pain. 12. PMID 27030709 DOI: 10.1177/1744806916628734 |
0.352 |
|
| 2016 |
Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature. PMID 27007855 DOI: 10.1038/Nature17198 |
0.796 |
|
| 2016 |
van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW, Goedhart J. A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells. Plos One. 11: e0146789. PMID 26799488 DOI: 10.1371/Journal.Pone.0146789 |
0.52 |
|
| 2016 |
Stumpf AD, Hoffmann C. Optical probes based on G protein-coupled receptors - added work or added value? British Journal of Pharmacology. 173: 255-66. PMID 26562218 DOI: 10.1111/Bph.13382 |
0.525 |
|
| 2015 |
Hoffmann C, Stumpf A. Comparison of A1 and A2A receptor dynamics using FRET based receptor sensors. Springerplus. 4: L6. PMID 27386223 DOI: 10.1186/2193-1801-4-S1-L6 |
0.601 |
|
| 2015 |
Hoffmann C, Castro M, Rinken A, Leurs R, Hill SJ, Vischer HF. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It. Molecular Pharmacology. 88: 552-60. PMID 26152198 DOI: 10.1124/Mol.115.099671 |
0.506 |
|
| 2015 |
van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms. Molecular Pharmacology. 88: 589-95. PMID 25972446 DOI: 10.1124/Mol.115.098897 |
0.562 |
|
| 2014 |
Lohse MJ, Hoffmann C. Arrestin interactions with G protein-coupled receptors. Handbook of Experimental Pharmacology. 219: 15-56. PMID 24292823 DOI: 10.1007/978-3-642-41199-1_2 |
0.748 |
|
| 2014 |
Bock A, Chirinda B, Krebs F, Messerer R, Bätz J, Muth M, Dallanoce C, Klingenthal D, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor. Nature Chemical Biology. 10: 18-20. PMID 24212135 DOI: 10.1038/Nchembio.1384 |
0.765 |
|
| 2013 |
Volff JN, Selz Y, Hoffmann C, Froschauer A, Schultheis C, Schmidt C, Zhou Q, Bernhardt W, Hanel R, Böhne A, Brunet F, Ségurens B, Couloux A, Bernard-Samain S, Barbe V, et al. Gene amplification and functional diversification of melanocortin 4 receptor at an extremely polymorphic locus controlling sexual maturation in the platyfish. Genetics. 195: 1337-52. PMID 24077304 DOI: 10.1534/Genetics.113.155952 |
0.567 |
|
| 2013 |
Lohse MJ, Hoffmann C, Calebiro D. Central theme G-protein-coupled receptors: GPCRs - Tracking individual receptors | GPCRs - Einzelnen Rezeptoren auf der Spur Biospektrum. 19: 600-604. DOI: 10.1007/S12268-013-0358-1 |
0.741 |
|
| 2013 |
Hoffmann C, Lohse M. FRET in living cells. Receptor conformations in a new light: GPCR-based FRET sensors | Rezeptorkonformationen in neuem Licht: GPCR-basierte FRET-Sensoren: FRET in lebenden Zellen Biospektrum. 19: 258-260. DOI: 10.1007/S12268-013-0304-2 |
0.658 |
|
| 2012 |
Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, et al. The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling. Nature Communications. 3: 1044. PMID 22948826 DOI: 10.1038/ncomms2028 |
0.78 |
|
| 2012 |
Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ. Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Science Signaling. 5: ra59. PMID 22894836 DOI: 10.1126/Scisignal.2002720 |
0.724 |
|
| 2012 |
Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH, Bünemann M, Lohse MJ. Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells. Molecular Pharmacology. 82: 236-45. PMID 22564786 DOI: 10.1124/Mol.112.077578 |
0.787 |
|
| 2012 |
Lohse MJ, Nuber S, Hoffmann C. Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacological Reviews. 64: 299-336. PMID 22407612 DOI: 10.1124/Pr.110.004309 |
0.727 |
|
| 2012 |
Lane JR, Klein Herenbrink C, van Westen GJ, Spoorendonk JA, Hoffmann C, IJzerman AP. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptor. Molecular Pharmacology. 81: 475-87. PMID 22188926 DOI: 10.1124/Mol.111.075937 |
0.546 |
|
| 2011 |
Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Molecular Pharmacology. 80: 1033-46. PMID 21880827 DOI: 10.1124/Mol.111.074674 |
0.726 |
|
| 2011 |
Hoffmann LS, Schmidt PM, Keim Y, Hoffmann C, Schmidt HH, Stasch JP. Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells. Plos One. 6: e23596. PMID 21858179 DOI: 10.1371/Journal.Pone.0023596 |
0.374 |
|
| 2011 |
Spille JH, Zürn A, Hoffmann C, Lohse MJ, Harms GS. Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells. Biophysical Journal. 100: 1139-48. PMID 21320460 DOI: 10.1016/J.Bpj.2010.08.080 |
0.611 |
|
| 2011 |
Ziegler N, Bätz J, Zabel U, Lohse MJ, Hoffmann C. FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorganic & Medicinal Chemistry. 19: 1048-54. PMID 20716489 DOI: 10.1016/J.Bmc.2010.07.060 |
0.627 |
|
| 2011 |
Schartl M, Schories S, Schmidt C, Fischer P, Lampert K, Volff J-, Hoffmann C, Lohse M. Regulation of Onset of Sexual Maturation by Melanocortin Receptor 4 Polymorphisms in Xiphophorus Indian Journal of Science and Technology. 4: 49-49. DOI: 10.17485/Ijst/2011/V4Is8/30877 |
0.562 |
|
| 2010 |
Hoffmann C. G protein-coupled receptor activation: amino acid movements caught infra-red-handed. Chembiochem : a European Journal of Chemical Biology. 11: 2247-9. PMID 20922739 DOI: 10.1002/Cbic.201000502 |
0.502 |
|
| 2010 |
Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature Protocols. 5: 1666-77. PMID 20885379 DOI: 10.1038/Nprot.2010.129 |
0.601 |
|
| 2010 |
Lampert KP, Schmidt C, Fischer P, Volff JN, Hoffmann C, Muck J, Lohse MJ, Ryan MJ, Schartl M. Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms. Current Biology : Cb. 20: 1729-34. PMID 20869245 DOI: 10.1016/J.Cub.2010.08.029 |
0.503 |
|
| 2010 |
Reiner S, Ambrosio M, Hoffmann C, Lohse MJ. Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 285: 36188-98. PMID 20837485 DOI: 10.1074/Jbc.M110.175604 |
0.631 |
|
| 2010 |
Zürn A, Klenk C, Zabel U, Reiner S, Lohse MJ, Hoffmann C. Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores. Bioconjugate Chemistry. 21: 853-9. PMID 20429545 DOI: 10.1021/Bc900394J |
0.789 |
|
| 2010 |
Maier-Peuschel M, Frölich N, Dees C, Hommers LG, Hoffmann C, Nikolaev VO, Lohse MJ. A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. The Journal of Biological Chemistry. 285: 8793-800. PMID 20083608 DOI: 10.1074/Jbc.M109.098517 |
0.793 |
|
| 2010 |
Zürn A, Klenk C, Zabel U, Lohse MJ, Hoffmann C. Site-Specific, Orthogonal Two Color Labeling of Different Proteins with Flash and Reash in Living Cells Biophysical Journal. 98: 393a. DOI: 10.1016/J.Bpj.2009.12.2122 |
0.652 |
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| 2009 |
Reiner S, Ziegler N, Leon C, Lorenz K, von Hayn K, Gachet C, Lohse MJ, Hoffmann C. beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Molecular Pharmacology. 76: 1162-71. PMID 19741005 DOI: 10.1124/Mol.109.060467 |
0.778 |
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| 2009 |
Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ, Hoffmann C. GPCR and G proteins: drug efficacy and activation in live cells. Molecular Endocrinology (Baltimore, Md.). 23: 590-9. PMID 19196832 DOI: 10.1210/Me.2008-0204 |
0.854 |
|
| 2009 |
Zürn A, Zabel U, Vilardaga JP, Schindelin H, Lohse MJ, Hoffmann C. Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Molecular Pharmacology. 75: 534-41. PMID 19106230 DOI: 10.1124/Mol.108.052399 |
0.795 |
|
| 2008 |
Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ. Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. The Journal of Biological Chemistry. 283: 30933-41. PMID 18703513 DOI: 10.1074/Jbc.M801472200 |
0.635 |
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| 2008 |
Jost CA, Reither G, Hoffmann C, Schultz C. Contribution of fluorophores to protein kinase C FRET probe performance. Chembiochem : a European Journal of Chemical Biology. 9: 1379-84. PMID 18442146 DOI: 10.1002/Cbic.200700728 |
0.319 |
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| 2008 |
Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M. Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in Pharmacological Sciences. 29: 159-65. PMID 18262662 DOI: 10.1016/J.Tips.2007.12.002 |
0.847 |
|
| 2008 |
Hoffmann C, Zürn A, Bünemann M, Lohse MJ. Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open. British Journal of Pharmacology. 153: S358-66. PMID 18059316 DOI: 10.1038/Sj.Bjp.0707615 |
0.792 |
|
| 2007 |
Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO. Monitoring receptor signaling by intramolecular FRET. Current Opinion in Pharmacology. 7: 547-53. PMID 17919975 DOI: 10.1016/J.Coph.2007.08.007 |
0.831 |
|
| 2007 |
Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in Protein Chemistry. 74: 167-88. PMID 17854658 DOI: 10.1016/S0065-3233(07)74005-6 |
0.851 |
|
| 2007 |
Selz Y, Braasch I, Hoffmann C, Schmidt C, Schultheis C, Schartl M, Volff JN. Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor. Gene. 401: 114-22. PMID 17707598 DOI: 10.1016/J.Gene.2007.07.005 |
0.521 |
|
| 2007 |
Hein P, Hoffmann C, Lohse MJ, Bünemann M. Direct Measurement Of Receptor/Gq Interaction The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A429-A |
0.784 |
|
| 2006 |
Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ, Bünemann M. Gs activation is time-limiting in initiating receptor-mediated signaling. The Journal of Biological Chemistry. 281: 33345-51. PMID 16963443 DOI: 10.1074/Jbc.M606713200 |
0.841 |
|
| 2006 |
Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP. Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of Biological Chemistry. 281: 24506-11. PMID 16787921 DOI: 10.1074/Jbc.M603266200 |
0.858 |
|
| 2006 |
Behr B, Hoffmann C, Ottolina G, Klotz KN. Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. The Journal of Biological Chemistry. 281: 18120-5. PMID 16648137 DOI: 10.1074/Jbc.M601791200 |
0.534 |
|
| 2006 |
Dallanoce C, Meroni G, De Amici M, Hoffmann C, Klotz KN, De Micheli C. Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes. Bioorganic & Medicinal Chemistry. 14: 4393-401. PMID 16530417 DOI: 10.1016/J.Bmc.2006.02.038 |
0.323 |
|
| 2006 |
Selz Y, Froschauer A, Hoffmann C, Schmidt C, Schultheis C, Zhou Q, Braasch I, B??hne A, Schartl M, Volff J. Two types of melanocortin receptors are overexpressed in melanoma in the fish Xiphophorus Melanoma Research. 16: S74-S75. DOI: 10.1097/00008390-200609001-00134 |
0.484 |
|
| 2005 |
Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M. Dynamics of receptor/G protein coupling in living cells. The Embo Journal. 24: 4106-14. PMID 16292347 DOI: 10.1038/Sj.Emboj.7600870 |
0.801 |
|
| 2005 |
Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/Nmeth742 |
0.825 |
|
| 2004 |
Hoffmann C, Soltysiak K, West PL, Jacobson KA. Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y 1/6 chimeric receptors. Biochemical Pharmacology. 68: 2075-86. PMID 15476678 DOI: 10.1016/J.Bcp.2004.07.014 |
0.62 |
|
| 2002 |
Kim SG, Ravi G, Hoffmann C, Jung YJ, Kim M, Chen A, Jacobson KA. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA. Biochemical Pharmacology. 63: 871-80. PMID 11911839 DOI: 10.1016/S0006-2952(02)00839-0 |
0.457 |
|
| 2001 |
Jacobson KA, Moro S, Hoffmann C, Kim YC, Kim HS, Ravi RG, Harden TK, Boyer JL. Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. Farmaco (Società Chimica Italiana : 1989). 56: 71-5. PMID 11347970 DOI: 10.1016/S0014-827X(01)01023-0 |
0.794 |
|
| 2000 |
Hoffmann C, Heine P, Pradel G, Kim YC, Jacobson KA, Zimmermann H. Inhibition of Ecto-Apyrase and Ecto-ATPase by Pyridoxal Phosphate-Related Compounds. Drug Development Research. 51: 151-158. PMID 27134333 DOI: 10.1002/1098-2299(200011)51:3<153::Aid-Ddr3>3.0.Co;2-X |
0.625 |
|
| 1999 |
Jacobson KA, Hoffmann C, Cattabeni F, Abbracchio MP. Adenosine-induced cell death: evidence for receptor-mediated signalling. Apoptosis : An International Journal On Programmed Cell Death. 4: 197-211. PMID 14634282 DOI: 10.1023/A:1009666707307 |
0.555 |
|
| 1999 |
Jacobson KA, Hoffmann C, Kim YC, Camaioni E, Nandanan E, Jang SY, Guo DP, Ji XD, von Kügelgen I, Moro S, Ziganshin AU, Rychkov A, King BF, Brown SG, Wildman SS, et al. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Progress in Brain Research. 120: 119-32. PMID 10550992 DOI: 10.1016/S0079-6123(08)63550-5 |
0.789 |
|
| 1999 |
Hoffmann C, Moro S, Nicholas RA, Harden TK, Jacobson KA. The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. The Journal of Biological Chemistry. 274: 14639-47. PMID 10329657 DOI: 10.1074/Jbc.274.21.14639 |
0.692 |
|
| 1999 |
Moro S, Hoffmann C, Jacobson KA. Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor. Biochemistry. 38: 3498-507. PMID 10090736 DOI: 10.1021/Bi982369V |
0.717 |
|
| 1998 |
Park KS, Hoffmann C, Kim HO, Padgett WL, Daly JW, Brambilla R, Motta C, Abbracchio MP, Jacobson KA. Activation and Desensitization of Rat A3-Adenosine Receptors by Selective Adenosine Derivatives and Xanthine-7-Ribosides. Drug Development Research. 44: 97-105. PMID 23487508 DOI: 10.1002/(Sici)1098-2299(199806/07)44:2/3<97::Aid-Ddr7>3.0.Co;2-5 |
0.489 |
|
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