Carsten Hoffmann - Publications

1998-2000 University of Würzburg, Würzburg, Bayern, Germany 

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 33148803 DOI: 10.1073/pnas.2013319117  1
2020 Hoffmann C, Müller CE, Zimmermann H. Obituary Geoff Burnstock (1929-2020). Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 32638049 DOI: 10.1007/s00210-020-01937-8  0.4
2020 Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/mol.119.118448  1
2019 Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M. Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nature Communications. 10: 5784. PMID 31857598 DOI: 10.1038/s41467-019-13722-0  0.56
2019 Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C. Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3). Molecular Pharmacology. PMID 31092552 DOI: 10.1124/mol.118.115477  1
2018 Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, ... ... Hoffmann C, et al. Lack of beta-arrestin signaling in the absence of active G proteins. Nature Communications. 9: 341. PMID 29362459 DOI: 10.1038/s41467-017-02661-3  0.56
2017 Messerer R, Kauk M, Volpato D, Alonso Cañizal MC, Kloeckner J, Zabel U, Nuber S, Hoffmann C, Holzgrabe U. FRET Studies of Quinolone-Based Bitopic Ligands and their Structural Analogues at the Muscarinic M1 Receptor. Acs Chemical Biology. PMID 28117571 DOI: 10.1021/acschembio.6b00828  0.56
2016 Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature. PMID 27007855 DOI: 10.1038/nature17198  1
2015 van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJ. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms. Molecular Pharmacology. 88: 589-95. PMID 25972446 DOI: 10.1124/mol.115.098897  1
2014 Lohse MJ, Hoffmann C. Arrestin interactions with G protein-coupled receptors. Handbook of Experimental Pharmacology. 219: 15-56. PMID 24292823 DOI: 10.1007/978-3-642-41199-1_2  1
2013 Volff JN, Selz Y, Hoffmann C, Froschauer A, Schultheis C, Schmidt C, Zhou Q, Bernhardt W, Hanel R, Böhne A, Brunet F, Ségurens B, Couloux A, Bernard-Samain S, Barbe V, et al. Gene amplification and functional diversification of melanocortin 4 receptor at an extremely polymorphic locus controlling sexual maturation in the platyfish. Genetics. 195: 1337-52. PMID 24077304 DOI: 10.1534/genetics.113.155952  1
2012 Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, et al. The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling. Nature Communications. 3: 1044. PMID 22948826 DOI: 10.1038/ncomms2028  1
2012 Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ. Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Science Signaling. 5: ra59. PMID 22894836 DOI: 10.1126/scisignal.2002720  1
2012 Hoffmann C, Nuber S, Zabel U, Ziegler N, Winkler C, Hein P, Berlot CH, Bünemann M, Lohse MJ. Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells. Molecular Pharmacology. 82: 236-45. PMID 22564786 DOI: 10.1124/mol.112.077578  1
2012 Lohse MJ, Nuber S, Hoffmann C. Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacological Reviews. 64: 299-336. PMID 22407612 DOI: 10.1124/pr.110.004309  1
2012 Lane JR, Klein Herenbrink C, van Westen GJ, Spoorendonk JA, Hoffmann C, IJzerman AP. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptor. Molecular Pharmacology. 81: 475-87. PMID 22188926 DOI: 10.1124/mol.111.075937  1
2011 Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Molecular Pharmacology. 80: 1033-46. PMID 21880827 DOI: 10.1124/mol.111.074674  1
2011 Hoffmann LS, Schmidt PM, Keim Y, Hoffmann C, Schmidt HH, Stasch JP. Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells. Plos One. 6: e23596. PMID 21858179 DOI: 10.1371/journal.pone.0023596  1
2011 Spille JH, Zürn A, Hoffmann C, Lohse MJ, Harms GS. Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells. Biophysical Journal. 100: 1139-48. PMID 21320460 DOI: 10.1016/j.bpj.2010.08.080  1
2011 Ziegler N, Bätz J, Zabel U, Lohse MJ, Hoffmann C. FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorganic & Medicinal Chemistry. 19: 1048-54. PMID 20716489 DOI: 10.1016/j.bmc.2010.07.060  1
2010 Hoffmann C. G protein-coupled receptor activation: amino acid movements caught infra-red-handed. Chembiochem : a European Journal of Chemical Biology. 11: 2247-9. PMID 20922739 DOI: 10.1002/cbic.201000502  1
2010 Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature Protocols. 5: 1666-77. PMID 20885379 DOI: 10.1038/nprot.2010.129  1
2010 Lampert KP, Schmidt C, Fischer P, Volff JN, Hoffmann C, Muck J, Lohse MJ, Ryan MJ, Schartl M. Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms. Current Biology : Cb. 20: 1729-34. PMID 20869245 DOI: 10.1016/j.cub.2010.08.029  1
2010 Reiner S, Ambrosio M, Hoffmann C, Lohse MJ. Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 285: 36188-98. PMID 20837485 DOI: 10.1074/jbc.M110.175604  1
2010 Zürn A, Klenk C, Zabel U, Reiner S, Lohse MJ, Hoffmann C. Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores. Bioconjugate Chemistry. 21: 853-9. PMID 20429545 DOI: 10.1021/bc900394j  1
2010 Maier-Peuschel M, Frölich N, Dees C, Hommers LG, Hoffmann C, Nikolaev VO, Lohse MJ. A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. The Journal of Biological Chemistry. 285: 8793-800. PMID 20083608 DOI: 10.1074/jbc.M109.098517  1
2009 Reiner S, Ziegler N, Leon C, Lorenz K, von Hayn K, Gachet C, Lohse MJ, Hoffmann C. beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Molecular Pharmacology. 76: 1162-71. PMID 19741005 DOI: 10.1124/mol.109.060467  1
2009 Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ, Hoffmann C. GPCR and G proteins: drug efficacy and activation in live cells. Molecular Endocrinology (Baltimore, Md.). 23: 590-9. PMID 19196832 DOI: 10.1210/me.2008-0204  1
2008 Hoffmann C, Ziegler N, Reiner S, Krasel C, Lohse MJ. Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. The Journal of Biological Chemistry. 283: 30933-41. PMID 18703513 DOI: 10.1074/jbc.M801472200  1
2008 Jost CA, Reither G, Hoffmann C, Schultz C. Contribution of fluorophores to protein kinase C FRET probe performance. Chembiochem : a European Journal of Chemical Biology. 9: 1379-84. PMID 18442146 DOI: 10.1002/cbic.200700728  1
2008 Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M. Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in Pharmacological Sciences. 29: 159-65. PMID 18262662 DOI: 10.1016/  1
2007 Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO. Monitoring receptor signaling by intramolecular FRET. Current Opinion in Pharmacology. 7: 547-53. PMID 17919975 DOI: 10.1016/j.coph.2007.08.007  1
2007 Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in Protein Chemistry. 74: 167-88. PMID 17854658 DOI: 10.1016/S0065-3233(07)74005-6  1
2007 Selz Y, Braasch I, Hoffmann C, Schmidt C, Schultheis C, Schartl M, Volff JN. Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor. Gene. 401: 114-22. PMID 17707598 DOI: 10.1016/j.gene.2007.07.005  1
2006 Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ, Bünemann M. Gs activation is time-limiting in initiating receptor-mediated signaling. The Journal of Biological Chemistry. 281: 33345-51. PMID 16963443 DOI: 10.1074/jbc.M606713200  1
2006 Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP. Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of Biological Chemistry. 281: 24506-11. PMID 16787921 DOI: 10.1074/jbc.M603266200  1
2006 Behr B, Hoffmann C, Ottolina G, Klotz KN. Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. The Journal of Biological Chemistry. 281: 18120-5. PMID 16648137 DOI: 10.1074/jbc.M601791200  1
2006 Dallanoce C, Meroni G, De Amici M, Hoffmann C, Klotz KN, De Micheli C. Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes. Bioorganic & Medicinal Chemistry. 14: 4393-401. PMID 16530417 DOI: 10.1016/j.bmc.2006.02.038  0.32
2005 Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M. Dynamics of receptor/G protein coupling in living cells. The Embo Journal. 24: 4106-14. PMID 16292347 DOI: 10.1038/sj.emboj.7600870  1
2005 Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/nmeth742  1
2004 Hoffmann C, Soltysiak K, West PL, Jacobson KA. Shift in purine/pyrimidine base recognition upon exchanging extracellular domains in P2Y 1/6 chimeric receptors. Biochemical Pharmacology. 68: 2075-86. PMID 15476678 DOI: 10.1016/j.bcp.2004.07.014  0.8
2002 Kim SG, Ravi G, Hoffmann C, Jung YJ, Kim M, Chen A, Jacobson KA. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA. Biochemical Pharmacology. 63: 871-80. PMID 11911839  0.8
2001 Jacobson KA, Moro S, Hoffmann C, Kim YC, Kim HS, Ravi RG, Harden TK, Boyer JL. Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. Farmaco (Società Chimica Italiana : 1989). 56: 71-5. PMID 11347970 DOI: 10.1016/S0014-827X(01)01023-0  1
2000 Hoffmann C, Heine P, Pradel G, Kim YC, Jacobson KA, Zimmermann H. Inhibition of Ecto-Apyrase and Ecto-ATPase by Pyridoxal Phosphate-Related Compounds. Drug Development Research. 51: 151-158. PMID 27134333 DOI: 10.1002/1098-2299(200011)51:3<153::AID-DDR3>3.0.CO;2-X  0.8
1999 Jacobson KA, Hoffmann C, Cattabeni F, Abbracchio MP. Adenosine-induced cell death: evidence for receptor-mediated signalling. Apoptosis : An International Journal On Programmed Cell Death. 4: 197-211. PMID 14634282  0.8
1999 Jacobson KA, Hoffmann C, Kim YC, Camaioni E, Nandanan E, Jang SY, Guo DP, Ji XD, von Kügelgen I, Moro S, Ziganshin AU, Rychkov A, King BF, Brown SG, Wildman SS, et al. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Progress in Brain Research. 120: 119-32. PMID 10550992  1
1999 Hoffmann C, Moro S, Nicholas RA, Harden TK, Jacobson KA. The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. The Journal of Biological Chemistry. 274: 14639-47. PMID 10329657 DOI: 10.1074/jbc.274.21.14639  1
1999 Moro S, Hoffmann C, Jacobson KA. Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor. Biochemistry. 38: 3498-507. PMID 10090736 DOI: 10.1021/bi982369v  0.8
1998 Park KS, Hoffmann C, Kim HO, Padgett WL, Daly JW, Brambilla R, Motta C, Abbracchio MP, Jacobson KA. Activation and Desensitization of Rat A3-Adenosine Receptors by Selective Adenosine Derivatives and Xanthine-7-Ribosides. Drug Development Research. 44: 97-105. PMID 23487508 DOI: 10.1002/(SICI)1098-2299(199806/07)44:2/3<97::AID-DDR7>3.0.CO;2-5  1
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