Martine Joyce Smit - Publications

chemistry Vrije Universiteit Amsterdam, Amsterdam, Netherlands 
Medicinal Chemistry

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJ, van Dongen GAMS, ... ... Smit MJ, et al. The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties. The Journal of Biological Chemistry. PMID 31519750 DOI: 10.1074/jbc.RA119.007796  1
2019 De Groof TWM, Mashayekhi V, Fan TS, Bergkamp ND, Sastre Toraño J, van Senten JR, Heukers R, Smit MJ, Oliveira S. Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells. Molecular Pharmaceutics. PMID 31244224 DOI: 10.1021/acs.molpharmaceut.9b00360  0.88
2019 Heukers R, De Groof TWM, Smit MJ. Nanobodies detecting and modulating GPCRs outside in and inside out. Current Opinion in Cell Biology. 57: 115-122. PMID 30849632 DOI: 10.1016/  0.4
2019 De Groof TWM, Bobkov V, Heukers R, Smit MJ. Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs. Molecular and Cellular Endocrinology. 484: 15-24. PMID 30690070 DOI: 10.1016/j.mce.2019.01.021  0.4
2018 Haselberg R, De Vijlder T, Heukers R, Smit MJ, Romijn EP, Somsen GW, Domínguez-Vega E. Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry. Analytica Chimica Acta. 1044: 181-190. PMID 30442400 DOI: 10.1016/j.aca.2018.08.024  0.32
2018 Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, ... ... Smit MJ, et al. CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry. Biochemical Pharmacology. PMID 30342024 DOI: 10.1016/j.bcp.2018.10.015  0.68
2018 Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ. Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions. Biochemical Pharmacology. PMID 30342023 DOI: 10.1016/j.bcp.2018.10.014  0.32
2018 Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, ... ... Smit MJ, et al. The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth. Oncogene. PMID 29706656 DOI: 10.1038/s41388-018-0255-7  1
2018 Hauwert NJ, Mocking TAM, Da Costa Pereira D, Kooistra AJ, Wijnen LM, Vreeker G, Verweij NWE, De Boer BH, Smit MJ, de Graaf C, Vischer HF, De Esch IJP, Wijtmans M, Leurs R. Synthesis and characterization of a bi-directional photoswitchable antagonist toolbox for real-time GPCR photopharmacology. Journal of the American Chemical Society. PMID 29470065 DOI: 10.1021/jacs.7b11422  1
2017 de Wit RH, Heukers R, Brink H, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer H, Bachelerie F, Smit MJ. CXCR4-specific Nanobodies as potential therapeutics for WHIM syndrome. The Journal of Pharmacology and Experimental Therapeutics. PMID 28768817 DOI: 10.1124/jpet.117.242735  0.92
2016 de Wit RH, Mujić-Delić A, van Senten JR, Ramos AF, Siderius M, Smit MJ. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. PMID 27602585 DOI: 10.18632/oncotarget.11817  0.92
2016 Lollinga WT, de Wit RH, Rahbar A, Vasse GF, Davoudi B, Diepstra A, Riezebos-Brilman A, Harmsen MC, Hillebrands JL, Söderberg-Naucler C, van Son WJ, Smit MJ, Sanders JS, van den Born J. Human Cytomegalovirus-Encoded Receptor US28 Is Expressed in Renal Allografts and Facilitates Viral Spreading In Vitro. Transplantation. PMID 27362315 DOI: 10.1097/TP.0000000000001289  0.92
2016 Jacobsen A, Heijmans N, Verkaar F, Smit MJ, Heringa J, van Amerongen R, Feenstra KA. Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling. Plos One. 11: e0155743. PMID 27218469 DOI: 10.1371/journal.pone.0155743  0.52
2016 de Munnik SM, van der Lee R, Velders DM, van Offenbeek J, Smits-de Vries L, Leurs R, Smit MJ, Vischer HF. The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R. Cellular Signalling. PMID 26931381 DOI: 10.1016/j.cellsig.2016.02.017  1
2016 de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ. Molecular Pharmacology of Chemokine Receptors. Methods in Enzymology. 570: 457-515. PMID 26921959 DOI: 10.1016/bs.mie.2015.12.002  1
2016 de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ. Molecular Pharmacology of Chemokine Receptors Methods in Enzymology. DOI: 10.1016/bs.mie.2015.12.002  1
2015 Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN. Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative cooperativity of the receptors. Haematologica. PMID 26589908 DOI: 10.3324/haematol.2015.133470  1
2015 Mladic M, Scholten DJ, Niessen WM, Somsen GW, Smit MJ, Kool J. At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1002: 42-53. PMID 26301479 DOI: 10.1016/j.jchromb.2015.08.004  0.56
2015 Mladic M, Scholten DJ, Wijtmans M, Falck D, Leurs R, Niessen WM, Smit MJ, Kool J. Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment. Analytical and Bioanalytical Chemistry. 407: 7067-81. PMID 26164305 DOI: 10.1007/s00216-015-8867-z  0.56
2015 Roth S, Kholodenko BN, Smit MJ, Bruggeman FJ. G Protein-Coupled Receptor Signaling Networks from a Systems Perspective. Molecular Pharmacology. 88: 604-16. PMID 26162865 DOI: 10.1124/mol.115.100057  1
2015 Bohn LM, Lohse MJ, Nitabach M, Taghert PH, Smit MJ. Exploring the Biology of GPCRs from In Vitro to In Vivo. Molecular Pharmacology. PMID 26162863 DOI: 10.1124/mol.115.100750  1
2015 Heo J, Dogra P, Masi TJ, Pitt EA, de Kruijf P, Smit MJ, Sparer TE. Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function. Journal of Immunology (Baltimore, Md. : 1950). 195: 227-36. PMID 25987741 DOI: 10.4049/jimmunol.1400291  0.56
2015 de Munnik SM, Kooistra AJ, van Offenbeek J, Nijmeijer S, de Graaf C, Smit MJ, Leurs R, Vischer HF. The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. Plos One. 10: e0124486. PMID 25894435 DOI: 10.1371/journal.pone.0124486  1
2015 de Munnik SM, Smit MJ, Leurs R, Vischer HF. Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors. Frontiers in Pharmacology. 6: 40. PMID 25805993 DOI: 10.3389/fphar.2015.00040  1
2015 Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R. Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3. Molecular Pharmacology. 87: 639-48. PMID 25576486 DOI: 10.1124/mol.114.095265  1
2015 Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease Models & Mechanisms. 8: 253-69. PMID 25573892 DOI: 10.1242/dmm.017756  1
2015 Wijtmans M, Scholten D, Mooij W, Smit MJ, De Esch IJP, De Graaf C, Leurs R. Exploring the cxcr3 chemokine receptor with small-molecule antagonists and agonists Topics in Medicinal Chemistry. 14: 119-186. DOI: 10.1007/7355_2014_75  0.56
2014 Dinkla K, El-Kebir M, Bucur CI, Siderius M, Smit MJ, Westenberg MA, Klau GW. eXamine: exploring annotated modules in networks. Bmc Bioinformatics. 15: 201. PMID 25002203 DOI: 10.1186/1471-2105-15-201  1
2014 Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells and Development. 23: 1959-74. PMID 24708339 DOI: 10.1089/scd.2013.0524  1
2014 Mujić-Delić A, de Wit RH, Verkaar F, Smit MJ. GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics. Trends in Pharmacological Sciences. 35: 247-55. PMID 24690241 DOI: 10.1016/  1
2014 Verkaar F, van Offenbeek J, van der Lee MM, van Lith LH, Watts AO, Rops AL, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AE, Vischer HF, Zaman GJ, Smit MJ. Chemokine cooperativity is caused by competitive glycosaminoglycan binding. Journal of Immunology (Baltimore, Md. : 1950). 192: 3908-14. PMID 24639348 DOI: 10.4049/jimmunol.1302159  1
2014 Vischer HF, Siderius M, Leurs R, Smit MJ. Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases? Nature Reviews. Drug Discovery. 13: 123-39. PMID 24445563 DOI: 10.1038/nrd4189  1
2014 Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R. Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211. Molecular Pharmacology. 85: 116-26. PMID 24174496 DOI: 10.1124/mol.113.088633  1
2013 Maussang D, Muji?-Deli? A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ. Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo. The Journal of Biological Chemistry. 288: 29562-72. PMID 23979133 DOI: 10.1074/jbc.M113.498436  1
2013 Zweemer AJ, Nederpelt I, Vrieling H, Hafith S, Doornbos ML, de Vries H, Abt J, Gross R, Stamos D, Saunders J, Smit MJ, Ijzerman AP, Heitman LH. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Molecular Pharmacology. 84: 551-61. PMID 23877010 DOI: 10.1124/mol.113.086850  1
2013 Blanchetot C, Verzijl D, Mujić-Delić A, Bosch L, Rem L, Leurs R, Verrips CT, Saunders M, de Haard H, Smit MJ. Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function. The Journal of Biological Chemistry. 288: 25173-82. PMID 23836909 DOI: 10.1074/jbc.M113.467969  1
2013 Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ, Vischer HF. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. The Journal of Biological Chemistry. 288: 7169-81. PMID 23341447 DOI: 10.1074/jbc.M112.406108  1
2013 Watts AO, van Lipzig MM, Jaeger WC, Seeber RM, van Zwam M, Vinet J, van der Lee MM, Siderius M, Zaman GJ, Boddeke HW, Smit MJ, Pfleger KD, Leurs R, Vischer HF. Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes. British Journal of Pharmacology. 168: 1662-74. PMID 23170857 DOI: 10.1111/bph.12064  1
2013 Vinet J, van Zwam M, Dijkstra IM, Brouwer N, van Weering HR, Watts A, Meijer M, Fokkens MR, Kannan V, Verzijl D, Vischer HF, Smit MJ, Leurs R, Biber K, Boddeke HW. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. British Journal of Pharmacology. 168: 1375-87. PMID 23121557 DOI: 10.1111/bph.12042  1
2012 Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands. Journal of Medicinal Chemistry. 55: 10572-83. PMID 23150943 DOI: 10.1021/jm301240t  1
2012 Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ. Constitutive β-catenin signaling by the viral chemokine receptor US28. Plos One. 7: e48935. PMID 23145028 DOI: 10.1371/journal.pone.0048935  1
2012 Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 143: 730-40. PMID 22643351 DOI: 10.1053/j.gastro.2012.05.034  1
2012 Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. Plos One. 7: e34192. PMID 22457824 DOI: 10.1371/journal.pone.0034192  1
2012 Wijtmans M, Maussang D, Sirci F, Scholten DJ, Canals M, Mujić-Delić A, Chong M, Chatalic KL, Custers H, Janssen E, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. European Journal of Medicinal Chemistry. 51: 184-92. PMID 22424612 DOI: 10.1016/j.ejmech.2012.02.041  1
2012 Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, Smit M, Soroceanu L, Cobbs CS. Consensus on the role of human cytomegalovirus in glioblastoma. Neuro-Oncology. 14: 246-55. PMID 22319219 DOI: 10.1093/neuonc/nor227  1
2012 Zoughlami Y, Voermans C, Brussen K, van Dort KA, Kootstra NA, Maussang D, Smit MJ, Hordijk PL, van Hennik PB. Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection. Blood. 119: 2024-32. PMID 22238325 DOI: 10.1182/blood-2011-06-364828  1
2012 Scholten DJ, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, de Esch IJ, Vischer HF, Smit MJ, Leurs R. Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3. British Journal of Pharmacology. 166: 898-911. PMID 21883151 DOI: 10.1111/j.1476-5381.2011.01648.x  1
2012 Koelink PJ, Overbeek SA, Braber S, de Kruijf P, Folkerts G, Smit MJ, Kraneveld AD. Targeting chemokine receptors in chronic inflammatory diseases: an extensive review. Pharmacology & Therapeutics. 133: 1-18. PMID 21839114 DOI: 10.1016/j.pharmthera.2011.06.008  1
2012 Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Pharmacological modulation of chemokine receptor function. British Journal of Pharmacology. 165: 1617-43. PMID 21699506 DOI: 10.1111/j.1476-5381.2011.01551.x  1
2012 Smit MJ. Targeting the chemokine receptor system Drug Discovery Today: Technologies. 9: e227-e228. DOI: 10.1016/j.ddtec.2012.09.006  1
2012 Siderius M, Wal M, Scholten DJ, Smit MJ, Sakmar TP, Leurs R, De Graaf C. Unnatural amino acids for the study of chemokine receptor structure and dynamics Drug Discovery Today: Technologies. 9: e301-e313. DOI: 10.1016/j.ddtec.2012.07.008  1
2012 Klarenbeek A, Maussang D, Blanchetot C, Saunders M, Van Der Woning S, Smit M, De Haard H, Hofman E. Targeting chemokines and chemokine receptors with antibodies Drug Discovery Today: Technologies. 9: e237-e244. DOI: 10.1016/j.ddtec.2012.05.003  1
2012 Wijtmans M, Scholten DJ, De Esch IJP, Smit MJ, Leurs R. Therapeutic targeting of chemokine receptors by small molecules Drug Discovery Today: Technologies. 9: e229-e236. DOI: 10.1016/j.ddtec.2012.03.004  1
2011 de Kruijf P, Lim HD, Roumen L, Renjaän VA, Zhao J, Webb ML, Auld DS, Wijkmans JC, Zaman GJ, Smit MJ, de Graaf C, Leurs R. Identification of a novel allosteric binding site in the CXCR2 chemokine receptor. Molecular Pharmacology. 80: 1108-18. PMID 21948388 DOI: 10.1124/mol.111.073825  1
2011 Wijtmans M, Verzijl D, Bergmans S, Lai M, Bosch L, Smit MJ, de Esch IJ, Leurs R. CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors. Bioorganic & Medicinal Chemistry. 19: 3384-93. PMID 21570852 DOI: 10.1016/j.bmc.2011.04.035  1
2011 Overbeek SA, Henricks PA, Srienc AI, Koelink PJ, de Kruijf P, Lim HD, Smit MJ, Zaman GJ, Garssen J, Nijkamp FP, Kraneveld AD, Folkerts G. N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. European Journal of Pharmacology. 668: 428-34. PMID 21458443 DOI: 10.1016/j.ejphar.2011.03.022  1
2011 Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell & Melanoma Research. 24: 207-18. PMID 20880198 DOI: 10.1111/j.1755-148X.2010.00781.x  1
2011 Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ. Herpesvirus-encoded GPCRs rewire cellular signaling. Molecular and Cellular Endocrinology. 331: 179-84. PMID 20398729 DOI: 10.1016/j.mce.2010.04.007  1
2010 Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, ... ... Smit MJ, et al. CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 20565-70. PMID 21059953 DOI: 10.1073/pnas.1012865107  1
2010 Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, ... ... Smit MJ, et al. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. The Journal of Clinical Investigation. 120: 3969-78. PMID 20978345 DOI: 10.1172/JCI42563  1
2010 Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile-Ramos A, Lira SA, Söderberg-Nauclér C, Smit MJ. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Science Signaling. 3: ra58. PMID 20682912 DOI: 10.1126/scisignal.2001180  1
2010 Nijmeijer S, Leurs R, Smit MJ, Vischer HF. The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning. The Journal of Biological Chemistry. 285: 29632-41. PMID 20622011 DOI: 10.1074/jbc.M110.115618  1
2010 de Kruijf P, Lim HD, Overbeek SA, Zaman GJ, Kraneveld AD, Folkerts G, Leurs R, Smit MJ. The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2. European Journal of Pharmacology. 643: 29-33. PMID 20599927 DOI: 10.1016/j.ejphar.2010.06.017  1
2010 Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic (Copenhagen, Denmark). 11: 660-74. PMID 20102549 DOI: 10.1111/j.1600-0854.2010.1045.x  1
2010 Vischer HF, Hulshof JW, Hulscher S, Fratantoni SA, Verheij MH, Victorina J, Smit MJ, de Esch IJ, Leurs R. Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28. Bioorganic & Medicinal Chemistry. 18: 675-88. PMID 20031418 DOI: 10.1016/j.bmc.2009.11.060  1
2010 Smit MJ, VanHook AM. Science Signaling podcast: 3 August 2010 Science Signaling. 3: pc16. DOI: 10.1126/scisignal.3133pc16  1
2009 Maussang D, Vischer HF, Leurs R, Smit MJ. Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function. Molecular Pharmacology. 76: 692-701. PMID 19570946 DOI: 10.1124/mol.109.057091  1
2009 Richter R, Casarosa P, Ständker L, Münch J, Springael JY, Nijmeijer S, Forssmann WG, Vischer HF, Vakili J, Detheux M, Parmentier M, Leurs R, Smit MJ. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. Journal of Immunology (Baltimore, Md. : 1950). 183: 1229-37. PMID 19553544 DOI: 10.4049/jimmunol.0802145  1
2009 Maussang D, Vischer HF, Schreiber A, Michel D, Smit MJ. Pharmacological and biochemical characterization of human cytomegalovirus-encoded G protein-coupled receptors. Methods in Enzymology. 460: 151-71. PMID 19446724 DOI: 10.1016/S0076-6879(09)05207-0  1
2009 Maussang D, Langemeijer E, Fitzsimons CP, Stigter-van Walsum M, Dijkman R, Borg MK, Slinger E, Schreiber A, Michel D, Tensen CP, van Dongen GA, Leurs R, Smit MJ. The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2. Cancer Research. 69: 2861-9. PMID 19318580 DOI: 10.1158/0008-5472.CAN-08-2487  1
2009 Wijtmans M, Verzijl D, van Dam CM, Bosch L, Smit MJ, Leurs R, de Esch IJ. Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy. Bioorganic & Medicinal Chemistry Letters. 19: 2252-7. PMID 19299127 DOI: 10.1016/j.bmcl.2009.02.093  1
2009 Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. Plos Pathogens. 5: e1000304. PMID 19229316 DOI: 10.1371/journal.ppat.1000304  1
2009 de Kruijf P, van Heteren J, Lim HD, Conti PG, van der Lee MM, Bosch L, Ho KK, Auld D, Ohlmeyer M, Smit MJ, Wijkmans JC, Zaman GJ, Smit MJ, Leurs R. Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor. The Journal of Pharmacology and Experimental Therapeutics. 329: 783-90. PMID 19190236 DOI: 10.1124/jpet.108.148387  0.56
2008 Vischer HF, Nijmeijer S, Smit MJ, Leurs R. Viral hijacking of human receptors through heterodimerization. Biochemical and Biophysical Research Communications. 377: 93-7. PMID 18823943 DOI: 10.1016/j.bbrc.2008.09.082  1
2008 van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. The Biochemical Journal. 414: 121-31. PMID 18452403 DOI: 10.1042/BJ20071583  1
2008 Wijtmans M, Verzijl D, Leurs R, de Esch IJ, Smit MJ. Towards small-molecule CXCR3 ligands with clinical potential. Chemmedchem. 3: 861-72. PMID 18442035 DOI: 10.1002/cmdc.200700365  1
2008 Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA. Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes. European Journal of Immunology. 38: 763-77. PMID 18286574 DOI: 10.1002/eji.200737618  1
2008 Verzijl D, Storelli S, Scholten DJ, Bosch L, Reinhart TA, Streblow DN, Tensen CP, Fitzsimons CP, Zaman GJ, Pease JE, de Esch IJ, Smit MJ, Leurs R. Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. The Journal of Pharmacology and Experimental Therapeutics. 325: 544-55. PMID 18270317 DOI: 10.1124/jpet.107.134783  0.56
2008 Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. British Journal of Pharmacology. 153: S154-66. PMID 18204488 DOI: 10.1038/sj.bjp.0707660  1
2007 Storelli S, Verzijl D, Al-Badie J, Elders N, Bosch L, Timmerman H, Smit MJ, De Esch IJ, Leurs R. Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists. Archiv Der Pharmazie. 340: 281-91. PMID 17562560 DOI: 10.1002/ardp.200700037  1
2007 Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, de Esch IJ, Richel D, Wijtmans M. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. Journal of Medicinal Chemistry. 50: 2424-31. PMID 17441704 DOI: 10.1021/jm061371e  1
2007 Smit MJ, Vischer HF, Bakker RA, Jongejan A, Timmerman H, Pardo L, Leurs R. Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity. Annual Review of Pharmacology and Toxicology. 47: 53-87. PMID 17029567 DOI: 10.1146/annurev.pharmtox.47.120505.105126  1
2006 Vischer HF, Hulshof JW, de Esch IJ, Smit MJ, Leurs R. Virus-encoded G-protein-coupled receptors: constitutively active (dys)regulators of cell function and their potential as drug target. Ernst Schering Foundation Symposium Proceedings. 187-209. PMID 17703583  1
2006 Verzijl D, Pardo L, van Dijk M, Gruijthuijsen YK, Jongejan A, Timmerman H, Nicholas J, Schwarz M, Murphy PM, Leurs R, Smit MJ. Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding. The Journal of Biological Chemistry. 281: 35327-35. PMID 16997914 DOI: 10.1074/jbc.M606877200  1
2006 Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, Pleskoff O, Michel D, van Dongen GA, Smit MJ. Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 13068-73. PMID 16924106 DOI: 10.1073/pnas.0604433103  1
2006 Hulshof JW, Vischer HF, Verheij MH, Fratantoni SA, Smit MJ, de Esch IJ, Leurs R. Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28. Bioorganic & Medicinal Chemistry. 14: 7213-30. PMID 16843661 DOI: 10.1016/j.bmc.2006.06.054  1
2006 Vischer HF, Vink C, Smit MJ. A viral conspiracy: hijacking the chemokine system through virally encoded pirated chemokine receptors. Current Topics in Microbiology and Immunology. 303: 121-54. PMID 16570859  1
2006 van Cleef KW, Smit MJ, Bruggeman CA, Vink C. Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines. Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology. 35: 343-8. PMID 16406796 DOI: 10.1016/j.jcv.2005.10.013  1
2006 Vischer HF, Leurs R, Smit MJ. HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks. Trends in Pharmacological Sciences. 27: 56-63. PMID 16352349 DOI: 10.1016/  1
2006 Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ. Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51. Molecular Pharmacology. 69: 888-98. PMID 16332987 DOI: 10.1124/mol.105.015222  1
2005 Hulshof JW, Casarosa P, Menge WM, Kuusisto LM, van der Goot H, Smit MJ, de Esch IJ, Leurs R. Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. Journal of Medicinal Chemistry. 48: 6461-71. PMID 16190772 DOI: 10.1021/jm050418d  1
2005 Pleskoff O, Casarosa P, Verneuil L, Ainoun F, Beisser P, Smit M, Leurs R, Schneider P, Michelson S, Ameisen JC. The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis. The Febs Journal. 272: 4163-77. PMID 16098198 DOI: 10.1111/j.1742-4658.2005.04829.x  1
2005 Storelli S, Verdijk P, Verzijl D, Timmerman H, van de Stolpe AC, Tensen CP, Smit MJ, De Esch IJ, Leurs R. Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 2910-3. PMID 15911279 DOI: 10.1016/j.bmcl.2005.03.070  1
2005 Beisser PS, Verzijl D, Gruijthuijsen YK, Beuken E, Smit MJ, Leurs R, Bruggeman CA, Vink C. The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase. Journal of Virology. 79: 441-9. PMID 15596837 DOI: 10.1128/JVI.79.1.441-449.2005  1
2005 Casarosa P, Waldhoer M, LiWang PJ, Vischer HF, Kledal T, Timmerman H, Schwartz TW, Smit MJ, Leurs R. CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. The Journal of Biological Chemistry. 280: 3275-85. PMID 15546882 DOI: 10.1074/jbc.M407536200  1
2004 Gruijthuijsen YK, Beuken EV, Smit MJ, Leurs R, Bruggeman CA, Vink C. Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling. The Journal of General Virology. 85: 897-909. PMID 15039532 DOI: 10.1099/vir.0.19709-0  1
2004 Verzijl D, Fitzsimons CP, Van Dijk M, Stewart JP, Timmerman H, Smit MJ, Leurs R. Differential activation of murine herpesvirus 68- and Kaposi's sarcoma-associated herpesvirus-encoded ORF74 G protein-coupled receptors by human and murine chemokines. Journal of Virology. 78: 3343-51. PMID 15016856 DOI: 10.1128/JVI.78.7.3343-3351.2004  1
2004 Hensbergen PJ, Verzijl D, Balog CI, Dijkman R, van der Schors RC, van der Raaij-Helmer EM, van der Plas MJ, Leurs R, Deelder AM, Smit MJ, Tensen CP. Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity. The Journal of Biological Chemistry. 279: 13402-11. PMID 14739277 DOI: 10.1074/jbc.M312814200  1
2004 Bakker RA, Casarosa P, Timmerman H, Smit MJ, Leurs R. Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors. The Journal of Biological Chemistry. 279: 5152-61. PMID 14610092 DOI: 10.1074/jbc.M309200200  1
2003 Govoni M, Bakker RA, van de Wetering I, Smit MJ, Menge WM, Timmerman H, Elz S, Schunack W, Leurs R. Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. Journal of Medicinal Chemistry. 46: 5812-24. PMID 14667234 DOI: 10.1021/jm030936t  1
2003 Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ. Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes. The Journal of Biological Chemistry. 278: 50010-23. PMID 14522997 DOI: 10.1074/jbc.M306530200  1
2003 Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD, Nelson JA. Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src Journal of Biological Chemistry. 278: 50456-50465. PMID 14506272 DOI: 10.1074/jbc.M307936200  1
2003 Hashimoto T, Harusawa S, Araki L, Zuiderveld OP, Smit MJ, Imazu T, Takashima S, Yamamoto Y, Sakamoto Y, Kurihara T, Leurs R, Bakker RA, Yamatodani A. A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. Journal of Medicinal Chemistry. 46: 3162-5. PMID 12825954 DOI: 10.1021/jm0300025  1
2003 Smit MJ, Vink C, Verzijl D, Casarosa P, Bruggeman CA, Leurs R. Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development. Current Drug Targets. 4: 431-41. PMID 12816350  1
2003 Smit MJ, Verdijk P, van der Raaij-Helmer EM, Navis M, Hensbergen PJ, Leurs R, Tensen CP. CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase. Blood. 102: 1959-65. PMID 12750173 DOI: 10.1182/blood-2002-12-3945  1
2003 Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. The Journal of Biological Chemistry. 278: 19473-82. PMID 12646575 DOI: 10.1074/jbc.M213179200  1
2003 Casarosa P, Menge WM, Minisini R, Otto C, van Heteren J, Jongejan A, Timmerman H, Moepps B, Kirchhoff F, Mertens T, Smit MJ, Leurs R. Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor. The Journal of Biological Chemistry. 278: 5172-8. PMID 12456673 DOI: 10.1074/jbc.M210033200  1
2002 Santore TA, Chen Y, Smit MJ, Iyengar R. Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 1671-6. PMID 11805301 DOI: 10.1073/pnas.032661999  1
2002 Smit MJ, Verzijl D, Casarosa P, Navis M, Timmerman H, Leurs R. Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways. Journal of Virology. 76: 1744-52. PMID 11799169 DOI: 10.1128/JVI.76.4.1744-1752.2002  1
2002 Gruijthuijsen YK, Casarosa P, Kaptein SJ, Broers JL, Leurs R, Bruggeman CA, Smit MJ, Vink C. The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion. Journal of Virology. 76: 1328-38. PMID 11773407  1
2002 Smit MJ, Bakker RA, Burstein ES. G protein-coupled receptors and proliferative signaling. Methods in Enzymology. 343: 430-47. PMID 11665583 DOI: 10.1016/S0076-6879(02)43150-3  1
2002 Leurs R, Hoffmann M, Alewijnse AE, Smit MJ, Timmerman H. Methods to determine the constitutive activity of histamine H2 receptors. Methods in Enzymology. 343: 405-16. PMID 11665581 DOI: 10.1016/S0076-6879(02)43148-5  1
2001 Bakker RA, Schoonus SB, Smit MJ, Timmerman H, Leurs R. Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling. Molecular Pharmacology. 60: 1133-42. PMID 11641442  1
2001 Vink C, Smit MJ, Leurs R, Bruggeman CA. The role of cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines in manipulation of and evasion from the immune system. Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology. 23: 43-55. PMID 11595583 DOI: 10.1016/S1386-6532(01)00184-6  1
2001 Drutel G, Peitsaro N, Karlstedt K, Wieland K, Smit MJ, Timmerman H, Panula P, Leurs R. Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Molecular Pharmacology. 59: 1-8. PMID 11125017  1
2001 Casarosa P, Bakker RA, Verzijl D, Navis M, Timmerman H, Leurs R, Smit MJ. Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28. The Journal of Biological Chemistry. 276: 1133-7. PMID 11050102 DOI: 10.1074/jbc.M008965200  1
2000 Smit MJ, Timmerman H, Verzijl D, Leurs R. Viral-encoded G-protein coupled receptors: new targets for drug research? Pharmaceutica Acta Helvetiae. 74: 299-304. PMID 10812973 DOI: 10.1016/S0165-7208(00)80033-1  1
2000 Alewijnse AE, Timmerman H, Jacobs EH, Smit MJ, Roovers E, Cotecchia S, Leurs R. The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor. Molecular Pharmacology. 57: 890-8. PMID 10779371  1
1999 Wieland K, Laak AM, Smit MJ, Kühne R, Timmerman H, Leurs R. Mutational analysis of the antagonist-binding site of the histamine H(1) receptor. The Journal of Biological Chemistry. 274: 29994-30000. PMID 10514483 DOI: 10.1074/jbc.274.42.29994  1
1999 Smit MJ, Hoffmann M, Timmerman H, Leurs R. Molecular properties and signalling pathways of the histamine H1 receptor. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 29: 19-28. PMID 10444208  1
1998 Leurs R, Smit MJ, Alewijnse AE, Timmerman H. Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends in Biochemical Sciences. 23: 418-22. PMID 9852759 DOI: 10.1016/S0968-0004(98)01287-0  1
1998 Smit MJ, Verzijl D, Iyengar R. Identity of adenylyl cyclase isoform determines the rate of cell cycle progression in NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 15084-9. PMID 9844019 DOI: 10.1073/pnas.95.25.15084  1
1998 Alewijnse AE, Smit MJ, Hoffmann M, Verzijl D, Timmerman H, Leurs R. Constitutive activity and structural instability of the wild-type human H2 receptor. Journal of Neurochemistry. 71: 799-807. PMID 9681472  1
1998 Smit MJ, Timmerman H, Alewijnse AE, Leurs R. From histamine H2 receptor regulation to reclassification of H2 antagonists; inverse agonism as the basis for H2 receptor upregulation. Receptors & Channels. 5: 99-102. PMID 9606714  1
1998 Chen J, Bander JA, Santore TA, Chen Y, Ram PT, Smit MJ, Iyengar R. Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 2648-52. PMID 9482941 DOI: 10.1073/pnas.95.5.2648  1
1998 Bloemers SM, Verheule S, Peppelenbosch MP, Smit MJ, Tertoolen LG, de Laat S. Sensitization of the histamine H1 receptor by increased ligand affinity. The Journal of Biological Chemistry. 273: 2249-55. PMID 9442068 DOI: 10.1074/jbc.273.4.2249  1
1998 Smit MJ, Iyengar R. Mammalian adenylyl cyclases. Advances in Second Messenger and Phosphoprotein Research. 32: 1-21. PMID 9421583  1
1997 Alewijnse AE, Smit MJ, Rodriguez Pena MS, Verzijl D, Timmerman H, Leurs R. Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active G(S)-coupled receptors. Febs Letters. 419: 171-4. PMID 9428628  1
1997 Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Proceedings of the National Academy of Sciences of the United States of America. 94: 14100-4. PMID 9391159 DOI: 10.1073/pnas.94.25.14100  1
1996 Smit MJ, Timmerman H, Hijzelendoorn JC, Fukui H, Leurs R. Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells. British Journal of Pharmacology. 117: 1071-80. PMID 8882599  1
1996 Smit MJ, Timmerman H, Blauw J, Beukers MW, Roovers E, Jacobs EH, Hoffmann M, Leurs R. The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation. Journal of Neurochemistry. 67: 1791-800. PMID 8863482  1
1996 Smit MJ, Leurs R, Alewijnse AE, Blauw J, Van Nieuw Amerongen GP, Van De Vrede Y, Roovers E, Timmerman H. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proceedings of the National Academy of Sciences of the United States of America. 93: 6802-7. PMID 8692899  1
1996 Smit MJ, Roovers E, Timmerman H, van de Vrede Y, Alewijnse AE, Leurs R. Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists. The Journal of Biological Chemistry. 271: 7574-82. PMID 8631790  1
1995 ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation. Journal of Computer-Aided Molecular Design. 9: 319-30. PMID 8523041  1
1995 Leurs R, Smit MJ, Meeder R, Ter Laak AM, Timmerman H. Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists. Biochemical and Biophysical Research Communications. 214: 110-7. PMID 7669031  1
1995 Smit MJ, Timmerman H, Alewijnse AE, Punin M, van den Nieuwenhof I, Blauw J, van Minnen J, Leurs R. Visualization of agonist-induced internalization of histamine H2 receptors. Biochemical and Biophysical Research Communications. 214: 1138-45. PMID 7575521  1
1995 Leurs R, Smit MJ, Timmerman H. Molecular pharmacological aspects of histamine receptors. Pharmacology & Therapeutics. 66: 413-63. PMID 7494855  1
1994 Leurs R, Smit MJ, Tensen CP, Ter Laak AM, Timmerman H. Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists. Biochemical and Biophysical Research Communications. 201: 295-301. PMID 8198587  1
1994 Leurs R, Smit MJ, Menge WM, Timmerman H. Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells. British Journal of Pharmacology. 112: 847-54. PMID 7921611  1
1994 Smit MJ, Leurs R, Shukrula SR, Bast A, Timmerman H. Rapid desensitization of the histamine H2 receptor on the human monocytic cell line U937. European Journal of Pharmacology. 288: 17-25. PMID 7705464  1
1993 Bloemers SM, Leurs R, Smit MJ, Verheule S, Tertoolen LG, Timmerman H, de Laat SW. Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors. Biochemical and Biophysical Research Communications. 191: 118-25. PMID 8447817 DOI: 10.1006/bbrc.1993.1192  1
1993 Smit MJ, Leurs R, Bloemers SM, Tertoolen LG, Bast A, De Laat SW, Timmerman H. Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor. European Journal of Pharmacology. 247: 223-6. PMID 8282011 DOI: 10.1016/0922-4106(93)90082-K  1
1992 Smit MJ, Bloemers SM, Leurs R, Tertoolen LG, Bast A, de Laat SW, Timmerman H. Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways. British Journal of Pharmacology. 107: 448-55. PMID 1422591  1
1991 Leurs R, Smit MJ, Bast A, Timmerman H. Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy. European Journal of Pharmacology. 196: 319-22. PMID 1654256  1
1991 Leurs R, Smit MJ, Brozius MM, Jansen W, Bast A, Timmerman H. Is protein kinase C involved in histamine H1-receptor desensitization? Agents and Actions. Supplements. 33: 393-402. PMID 1647131  1
1991 Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H. Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. British Journal of Pharmacology. 102: 179-85. PMID 1646056  1
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