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Patrick M. Woster - Publications

Affiliations: 
Medical University of South Carolina, Charleston, SC, United States 
Area:
Medicinal Chemistry
Website:
https://www.sccp.sc.edu/Patrick-Woster

130 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Holshouser S, Cafiero R, Robinson M, Kirkpatrick J, Casero RA, Hyacinth HI, Woster PM. Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. Acs Omega. 5: 14750-14758. PMID 32596612 DOI: 10.1021/acsomega.0c01585  0.76
2020 Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, et al. Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. PMID 32350444 DOI: 10.1038/S41388-020-1304-6  0.96
2019 Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA, Woster PM. Dual inhibitors of LSD1 and spermine oxidase. Medchemcomm. 10: 778-790. PMID 31191868 DOI: 10.1039/C8Md00610E  0.76
2019 El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM. Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations. Frontiers in Cellular and Infection Microbiology. 9: 9. PMID 30838177 DOI: 10.3389/Fcimb.2019.00009  0.48
2018 Murray Stewart T, Dunston TT, Woster PM, Casero RA. Polyamine catabolism and oxidative damage. The Journal of Biological Chemistry. PMID 30333229 DOI: 10.1074/Jbc.Tm118.003337  0.76
2018 Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA. Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. Plos One. 13: e0202677. PMID 30138353 DOI: 10.1371/Journal.Pone.0202677  0.76
2018 Kirkpatrick JE, Kirkwood KL, Woster PM. Inhibition of the Histone Demethylase KDM4B Leads to Activation of KDM1A, Attenuates Bacterial-Induced Pro-Inflammatory Cytokine Release, and Reduces Osteoclastogenesis. Epigenetics. PMID 29927684 DOI: 10.1080/15592294.2018.1481703  0.56
2018 Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612]. Bioorganic & Medicinal Chemistry. PMID 29859749 DOI: 10.1016/J.Bmc.2018.05.032  1
2016 Murray-Stewart TR, Woster PM, Casero RA. Targeting polyamine metabolism for cancer therapy and prevention. The Biochemical Journal. 473: 2937-53. PMID 27679855 DOI: 10.1042/Bcj20160383  0.76
2016 Wang B, Pachaiyappan B, Gruber JD, Schmidt MG, Zhang Y, Woster PM. Antibacterial Diamines Targeting Bacterial Membranes. Journal of Medicinal Chemistry. PMID 26964758 DOI: 10.1021/Acs.Jmedchem.5B01912  1
2016 Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Epigenetics: Novel Therapeutics Targeting Epigenetics. Journal of Medicinal Chemistry. PMID 26824165 DOI: 10.1021/Acs.Jmedchem.6B00098  1
2015 Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group. Medchemcomm. 6: 613-618. PMID 26005563 DOI: 10.1039/C4Md00401A  1
2015 Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorganic & Medicinal Chemistry. 23: 1601-12. PMID 25725609 DOI: 10.1016/J.Bmc.2015.01.049  1
2015 Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of Biological Chemistry. 290: 9812-22. PMID 25713082 DOI: 10.1074/Jbc.M114.616219  1
2015 Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorganic & Medicinal Chemistry. 23: 5131-43. PMID 25684422 DOI: 10.1016/J.Bmc.2015.01.036  0.76
2015 Conway SJ, Woster PM, Shen JK, Georg G, Wang S. Epigenetics: novel therapeutics targeting epigenetics. Journal of Medicinal Chemistry. 58: 523-4. PMID 25532017 DOI: 10.1021/jm501941q  1
2015 Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, ... ... Woster PM, et al. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene. 34: 3429-40. PMID 25174398 DOI: 10.1038/Onc.2014.273  1
2015 Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group Medchemcomm. 6: 613-618. DOI: 10.1039/c4md00401a  1
2014 Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. Medchemcomm. 5: 1863-1870. PMID 25580204 DOI: 10.1039/C4Md00283K  0.96
2014 Pachaiyappan B, Woster PM. Design of small molecule epigenetic modulators Bioorganic and Medicinal Chemistry Letters. 24: 21-32. PMID 24300735 DOI: 10.1016/J.Bmcl.2013.11.001  1
2014 Yedidi RS, Liu Z, Kovari IA, Woster PM, Kovari LC. P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease Journal of Molecular Graphics and Modelling. 47: 18-24. PMID 24291501 DOI: 10.1016/J.Jmgm.2013.10.010  1
2014 Hayes CS, DeFeo-Mattox K, Woster PM, Gilmour SK. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids. 46: 543-552. PMID 23884694 DOI: 10.1007/S00726-013-1559-0  1
2014 Murray-Stewart T, Woster PM, Casero RA. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines Amino Acids. 46: 585-594. PMID 23508577 DOI: 10.1007/S00726-013-1485-1  1
2014 Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors Medchemcomm. 5: 1863-1870. DOI: 10.1039/c4md00283k  1
2014 Kumarasinghe IR, Woster PM. Synthesis and evaluation of novel cyclic peptide inhibitors of lysine-specific demethylase 1 Acs Medicinal Chemistry Letters. 5: 29-33. DOI: 10.1021/ml4002997  1
2014 Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2015.01.036  1
2013 Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease Bioorganic and Medicinal Chemistry. 21: 7430-7434. PMID 24128815 DOI: 10.1016/J.Bmc.2013.09.045  1
2013 Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Molecular Cancer Therapeutics. 12: 2088-2099. PMID 23943804 DOI: 10.1158/1535-7163.Mct-13-0418  1
2013 Nowotarski SL, Woster PM, Casero RA. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Reviews in Molecular Medicine. 15: e3. PMID 23432971 DOI: 10.1017/Erm.2013.3  1
2013 Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner Biochemical Journal. 449: 459-468. PMID 23072722 DOI: 10.1042/Bj20121360  1
2012 Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators. Medchemcomm. 3: 14-21. PMID 23293738 DOI: 10.1039/C1Md00220A  1
2012 Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA, Woster PM. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1 Journal of Medicinal Chemistry. 55: 7378-7391. PMID 22876979 DOI: 10.1021/Jm3002845  1
2012 Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 421: 413-417. PMID 22469467 DOI: 10.1016/J.Bbrc.2012.03.096  1
2012 Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA, Marton L, Woster P, Minden MD, Dugas M, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Medicine. 18: 605-11. PMID 22406747 DOI: 10.1038/Nm.2661  1
2012 Silva TM, Oredsson S, Persson L, Woster P, Marques MPM. Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis Journal of Inorganic Biochemistry. 108: 1-7. PMID 22265832 DOI: 10.1016/j.jinorgbio.2011.11.021  1
2012 Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 42: 529-38. PMID 21814790 DOI: 10.1007/S00726-011-1030-Z  1
2012 Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids. 42: 887-98. PMID 21805138 DOI: 10.1007/S00726-011-1004-1  1
2012 Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TMD, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators Medchemcomm. 3: 14-21. DOI: 10.1039/c1md00220a  1
2011 Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ. Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. The Journal of Biological Chemistry. 286: 43301-12. PMID 22025614 DOI: 10.1074/Jbc.M111.307835  1
2011 Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM. Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities Journal of Medicinal Chemistry. 54: 6624-6633. PMID 21882831 DOI: 10.1021/jm200463z  1
2011 Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 15354-9. PMID 21876161 DOI: 10.1073/Pnas.1010203108  1
2011 Woster PM. Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 720: 475-491. PMID 21318894 DOI: 10.1007/978-1-61779-034-8_31  1
2010 Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA, Mariottini P. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm Bmc Cancer. 10. PMID 20946629 DOI: 10.1186/1471-2407-10-555  1
2010 Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. (Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators Journal of Medicinal Chemistry. 53: 5197-5212. PMID 20568780 DOI: 10.1021/Jm100217A  1
2010 Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents Journal of Medicinal Chemistry. 53: 4234-4247. PMID 20438064 DOI: 10.1021/Jm100233B  1
2010 Lee SB, Park JH, Woster PM, Casero RA, Park MH. Suppression of exogenous gene expression by spermidine/spermine N 1-acetyltransferase 1 (SSAT1) cotransfection Journal of Biological Chemistry. 285: 15548-15556. PMID 20212040 DOI: 10.1074/Jbc.M109.092007  1
2010 Pledgie-Tracy A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA, Davidson NE. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemotherapy and Pharmacology. 65: 1067-81. PMID 19727732 DOI: 10.1007/S00280-009-1112-8  1
2010 Woster PM. Epigenetic Targets and Cancer Drug Discovery Annual Reports in Medicinal Chemistry. 45: 245-260. DOI: 10.1016/S0065-7743(10)45015-0  1
2009 Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells Journal of Cellular and Molecular Medicine. 13: 1877-1885. PMID 20141611 DOI: 10.1111/j.1582-4934.2009.00672.x  1
2009 Huang Y, Marton LJ, Woster PM, Casero RA. Polyamine analogues targeting epigenetic gene regulation Essays in Biochemistry. 46: 95-110. PMID 20095972 DOI: 10.1042/Bse0460007  1
2009 Senanayake MDT, Amunugama H, Boncher TD, Casero RA, Woster PM. Design of polyamine-based therapeutic agents: New targets and new directions Essays in Biochemistry. 46: 77-94. PMID 20095971 DOI: 10.1042/BSE0460006  1
2009 Woster PM. Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 years of excellence Journal of Medicinal Chemistry. 52: 7333-7338. PMID 19954244 DOI: 10.1021/jm901089d  1
2009 Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7217-28. PMID 19934284 DOI: 10.1158/1078-0432.Ccr-09-1293  1
2009 Basu HS, Thompson TA, Church DR, Clower CC, Mehraein-Ghomi F, Amlong CA, Martin CT, Woster PM, Lindstrom MJ, Wilding G. A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Research. 69: 7689-95. PMID 19773450 DOI: 10.1158/0008-5472.Can-08-2472  1
2009 Casero RA, Woster PM. Recent advances in the development of polyamine analogues as antitumor agents Journal of Medicinal Chemistry. 52: 4551-4573. PMID 19534534 DOI: 10.1021/Jm900187V  1
2009 Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts Biochemical Journal. 422: 101-109. PMID 19473115 DOI: 10.1042/Bj20090411  1
2009 Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM. Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi Antimicrobial Agents and Chemotherapy. 53: 2599-2604. PMID 19223636 DOI: 10.1128/Aac.00267-08  1
2008 Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes Cancer Research. 68: 2214-2222. PMID 18381427 DOI: 10.1158/0008-5472.Can-07-5030  1
2008 Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA, Woster PM. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors Journal of Medicinal Chemistry. 51: 2447-2456. PMID 18348516 DOI: 10.1021/Jm701384X  1
2008 Woster PM. Chemistry is crucial to education Drug Topics. 152.  1
2007 Wang X, Feith DJ, Welsh P, Coleman CS, Lopez C, Woster PM, O'brien TG, Pegg AE. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis Carcinogenesis. 28: 2404-2411. PMID 17675337 DOI: 10.1093/Carcin/Bgm162  1
2007 Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proceedings of the National Academy of Sciences of the United States of America. 104: 8023-8. PMID 17463086 DOI: 10.1073/Pnas.0700720104  1
2007 Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero RA. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide Amino Acids. 33: 231-240. PMID 17396215 DOI: 10.1007/S00726-007-0513-4  1
2007 Boncher T, Bi X, Varghese S, Casero RA, Woster PM. Polyamine-based analogues as biochemical probes and potential therapeutics Biochemical Society Transactions. 35: 356-363. PMID 17371278 DOI: 10.1042/BST0350356  1
2006 Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity Bioorganic and Medicinal Chemistry Letters. 16: 3229-3232. PMID 16616495 DOI: 10.1016/J.Bmcl.2006.03.048  1
2006 Khan FD, Roychowdhury S, Nemes R, Vyas PM, Woster PM, Svensson CK. Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes Toxicology. 218: 90-99. PMID 16289751 DOI: 10.1016/J.Tox.2005.10.002  1
2006 Woster PM. Polyamine structure and synthetic analogs Polyamine Cell Signaling: Polyamine Cell Signaling. 3-24. DOI: 10.1007/978-1-59745-145-1_1  1
2006 Woster PM. Antiprotozoal agents (African trypanosomiasis, chagas disease, and leishmaniasis) Comprehensive Medicinal Chemistry Ii. 7: 815-843.  1
2005 Casero RA, Frydman B, Stewart TM, Woster PM. Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proceedings of the Western Pharmacology Society. 48: 24-30. PMID 16416654  1
2005 Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA. Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of Cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines Journal of Biological Chemistry. 280: 39843-39851. PMID 16207710 DOI: 10.1074/Jbc.M508177200  1
2005 Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA, Woster PM. Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors Journal of Medicinal Chemistry. 48: 6350-6365. PMID 16190761 DOI: 10.1021/Jm0505009  1
2005 Huang Y, Pledgie A, Rubin E, Marton LJ, Woster PM, Sukumar S, Casero RA, Davidson NE. Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells Cancer Biology and Therapy. 4: 1006-1013. PMID 16131835 DOI: 10.4161/Cbt.4.9.1970  1
2005 Khomutov AR, Grigorenko NA, Skuridin SG, Demin AV, Vepsalainen J, Casero RA, Woster PM. A charge-deficient analogue of spermine with chelating properties Bioorganicheskaya Khimiya. 31: 303-311. PMID 16004389 DOI: 10.1007/S11171-005-0037-1  1
2005 Vyas PM, Roychowdhury S, Woster PM, Svensson CK. Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes Biochemical Pharmacology. 70: 275-286. PMID 15894292 DOI: 10.1016/J.Bcp.2005.04.023  1
2005 Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): Potential role in determining drug sensitivity Cancer Chemotherapy and Pharmacology. 56: 83-90. PMID 15791459 DOI: 10.1007/S00280-004-0936-5  1
2005 Wang Y, Hacker A, Murray-Stewart T, Fleischer JG, Woster PM, Casero RA. Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. The Biochemical Journal. 386: 543-7. PMID 15496143 DOI: 10.1042/Bj20041084  1
2004 Goosen TC, Cillié D, Bailey DG, Yu C, He K, Hollenberg PF, Woster PM, Cohen L, Williams JA, Rheeders M, Dijkstra HP. Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans. Clinical Pharmacology and Therapeutics. 76: 607-17. PMID 15592332 DOI: 10.1016/J.Clpt.2004.08.019  1
2004 Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M. Polyamine metabolism in a member of the phylum microspora (Encephalitozoon cuniculi): Effects of polyamine analogues Microbiology. 150: 1215-1224. PMID 15133083 DOI: 10.1099/Mic.0.26889-0  1
2003 Ndjonka D, Zou Y, Bi X, Woster P, Walter RD, Lüersen K. The activator-binding site of Onchocerca volvulus s-adenosylmethionine decarboxylase, a potential drug target Biological Chemistry. 384: 1195-1201. PMID 12974388 DOI: 10.1515/BC.2003.132  1
2003 Devereux W, Wang Y, Stewart TM, Hacker A, Smith R, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Ward TD, Woster PM, Casero RA. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemotherapy and Pharmacology. 52: 383-90. PMID 12827295 DOI: 10.1007/S00280-003-0662-4  1
2003 Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO Biochemical and Biophysical Research Communications. 304: 605-611. PMID 12727196 DOI: 10.1016/S0006-291X(03)00636-3  1
2003 Casero RA, Wang Y, Stewart TM, Devereux W, Hacker A, Wang Y, Smith R, Woster PM. The role of polyamine catabolism in anti-tumour drug response. Biochemical Society Transactions. 31: 361-5. PMID 12653639 DOI: 10.1042/Bst0310361  1
2003 Woster PM. Chapter 21. New therapies for malaria Annual Reports in Medicinal Chemistry. 38: 203-211. DOI: 10.1016/S0065-7743(03)38022-4  1
2003 Woster PM. Maintaining basic science content throughout the PharmD curriculum American Journal of Pharmaceutical Education. 67.  1
2002 Carlisle DL, Devereux WL, Hacker A, Woster PM, Casero RA. Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure Clinical Cancer Research. 8: 2684-2689. PMID 12171901  1
2002 Fraser AV, Woster PM, Wallace HM. Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite. The Biochemical Journal. 367: 307-12. PMID 12086584 DOI: 10.1042/Bj20020156  1
2002 Lawson KR, Marek S, Linehan JA, Woster PM, Casero RA, Payne CM, Gerner EW. Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase Clinical Cancer Research. 8: 1241-1247. PMID 12006544  1
2001 Wang Y, Devereux W, Woster PM, Casero R.A. J. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: An alternatively spliced homologue of the human transcription factor Biochemical Journal. 359: 387-392. PMID 11583586 DOI: 10.1042/0264-6021:3590387  1
2001 Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Research. 61: 5370-3. PMID 11454677  1
2001 Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA, Weiss LM, Rattendi D, Lane S, Bacchi CJ. Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity Bioorganic and Medicinal Chemistry Letters. 11: 1613-1617. PMID 11412992 DOI: 10.1016/S0960-894X(01)00315-8  1
2001 Hahm HA, Dunn VR, Butash KA, Deveraux WL, Woster PM, Casero R.A. J, Davidson NE. Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines Clinical Cancer Research. 7: 391-399. PMID 11234895  1
2001 Casero JA, Woster PM. Terminally alkylated polyamine analogues as chemotherapeutic agents Journal of Medicinal Chemistry. 44: 1-26. PMID 11141084 DOI: 10.1021/Jm000084M  1
2001 Woster PM. Chapter 10. New therapies for parasitic infection Annual Reports in Medicinal Chemistry. 36: 99-108. DOI: 10.1016/S0065-7743(01)36050-5  1
2000 Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. The Journal of Investigative Dermatology. 114: 1164-73. PMID 10844561 DOI: 10.1046/J.1523-1747.2000.00985.X  1
2000 Iyer R, Wu Z, Woster PM, Delcour AH. Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. Journal of Molecular Biology. 297: 933-45. PMID 10736228 DOI: 10.1006/Jmbi.2000.3599  1
2000 McCloskey DE, Woster PM, Casero RA, Davidson NE. Effects of the polyamine analogues N1-ethyl-N11- ((cyclopropyl)methyl)4,8-diazaundecane and N1-ethyl-N11- ((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells Clinical Cancer Research. 6: 17-23. PMID 10656427  1
2000 Nairn LM, Lindsay GS, Woster PM, Wallace HM. Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. Journal of Cellular Physiology. 182: 209-13. PMID 10623884 DOI: 10.1002/(Sici)1097-4652(200002)182:2<209::Aid-Jcp9>3.0.Co;2-8  1
1999 Davidson NE, Hahm HA, McCloskey DE, Woster PM, Casero RA. Clinical aspects of cell death in breast cancer: The polyamine pathway as a new target for treatment Endocrine-Related Cancer. 6: 69-73. PMID 10732790 DOI: 10.1677/Erc.0.0060069  1
1999 Reilly TP, Macarthur RD, Farrough MJ, Crane LR, Woster PM, Svensson CK. Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals? Journal of Pharmacology and Experimental Therapeutics. 291: 1356-1364. PMID 10565861  1
1999 Webb HK, Wu Z, Sirisoma N, Ha HC, Casero RA, Woster PM. 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple synthetic polyamine analogues that differentially alter tubulin polymerization Journal of Medicinal Chemistry. 42: 1415-1421. PMID 10212127 DOI: 10.1021/Jm980603+  1
1999 Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP, Warbasse LH, Woster PM, Schuetz JD, Watkins P. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein Clinical Pharmacology and Therapeutics. 65: 237-244. PMID 10096255 DOI: 10.1016/S0009-9236(99)70102-5  1
1999 Reilly TP, Woster PM, Svensson CK. Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: Implications for differences in adverse drug reactions Journal of Pharmacology and Experimental Therapeutics. 288: 951-959. PMID 10027831  1
1998 Nairn LM, Woster PM, Lindsay GS, Wallace HM. Comparison of polyamine analogue toxicity in two cell lines (HL-60 & MCF-7). Biochemical Society Transactions. 26: S371. PMID 10047885 DOI: 10.1042/Bst026S371  1
1998 Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA. The natural polyamine spermine functions directly as a free radical scavenger Proceedings of the National Academy of Sciences of the United States of America. 95: 11140-11145. PMID 9736703 DOI: 10.1073/Pnas.95.19.11140  1
1998 Ha HC, Woster PM, Casero RA. Unsymmetrically substituted polyamine analogue induces caspase- independent programmed cell death in Bcl-2-overexpressing cells Cancer Research. 58: 2711-2714. PMID 9661878  1
1998 Reilly TP, Bellevue FH, Woster PM, Svensson CK. Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone Biochemical Pharmacology. 55: 803-810. PMID 9586952 DOI: 10.1016/S0006-2952(97)00547-9  1
1998 Sirisoma NS, Woster PM. Synthesis of protected allylic amines via palladium(O)-catalyzed amination of allylic acetates Tetrahedron Letters. 39: 1489-1492. DOI: 10.1016/S0040-4039(98)00006-9  1
1998 Woster PM, Aoyama T, Satoh T, Yonemato M, Shibata J, Nonoshita K, Arai S, Kawakami K, Iwasawa Y, Sano H, Tanaka K, Monden Y, Kodera T, Arakawa H, Suzuki-Takahashi I, et al. A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyl transferase Chemtracts. 11: 840-844.  1
1997 Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, He K, Lown KS, Woster PM, Rahman A, Thummel KE, Fisher JM, Hollenberg PF, Watkins PB. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins Drug Metabolism and Disposition. 25: 1228-1233. PMID 9351897  1
1997 Ha HC, Woster PM, Yager JD, Casero RA. The role of polyamine catabolism in polyamine analogue-induced programmed cell death Proceedings of the National Academy of Sciences of the United States of America. 94: 11557-11562. PMID 9326648 DOI: 10.1073/Pnas.94.21.11557  1
1997 Bellevue FH, Woster PM, Edwards DJ, He K, Hollenberg PF. Synthesis and biological evaluation of 6',7'-dihydroxybergamottin (6,7-DHB, a naturally occurring inhibitor of cytochrome P450 3A4 Bioorganic and Medicinal Chemistry Letters. 7: 2593-2598. DOI: 10.1016/S0960-894X(97)10043-9  1
1996 McCloskey DE, Yang J, Woster PM, Davidson NE, Casero RA. Polyamine analogue induction of programmed cell death in human lung tumor cells Clinical Cancer Research. 2: 441-446. PMID 9816189  1
1996 Edwards DJ, Bellevue FH, Woster PM. Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice Drug Metabolism and Disposition. 24: 1287-1290. PMID 8971132  1
1996 Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase Bioorganic and Medicinal Chemistry. 4: 825-836. PMID 8818232 DOI: 10.1016/0968-0896(96)00072-7  1
1996 Bellevue FH, Boahbedason M, Wu R, Woster PM, Casero RA, Rattendi D, Lane S, Bacchi CJ. Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity Bioorganic and Medicinal Chemistry Letters. 6: 2765-2770. DOI: 10.1016/S0960-894X(96)00510-0  1
1995 Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM. S-(5′-deoxy-5′-adenosyl)-1-aminoxy-4-(methylsulfonio)-2- cyclopentene (AdoMao): An irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity Journal of Medicinal Chemistry. 38: 1770-1777. PMID 7752200 DOI: 10.1021/Jm00010A021  1
1995 Wu YQ, Woster PM. Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac) Biochemical Pharmacology. 49: 1125-1133. PMID 7748194 DOI: 10.1016/0006-2952(95)98510-G  1
1995 Casero RA, Mank AR, Saab NH, Wu R, Dyer WJ, Woster PM. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemotherapy and Pharmacology. 36: 69-74. PMID 7720179 DOI: 10.1007/Bf00685735  1
1995 McCloskey DE, Casero RA, Woster PM, Davidson NE. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Research. 55: 3233-6. PMID 7614453  1
1995 Felschow DM, MacDiarmid J, Bardos T, Wu R, Woster PM, Porter CW. Photoaffinity labeling of a cell surface polyamine binding protein Journal of Biological Chemistry. 270: 28705-28711. PMID 7499391 DOI: 10.1074/Jbc.270.48.28705  1
1994 Vage C, Saab N, Woster PM, Svensson CK. Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood. Toxicology and Applied Pharmacology. 129: 309-16. PMID 7992320 DOI: 10.1006/Taap.1994.1255  1
1993 Saab NH, West EE, Bieszk NC, Preuss CV, Mank AR, Casero RA, Woster PM. Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. Journal of Medicinal Chemistry. 36: 2998-3004. PMID 8411017 DOI: 10.1021/Jm00072A020  1
1993 Wu YQ, Woster PM. Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli. Bioorganic & Medicinal Chemistry. 1: 349-60. PMID 8081865 DOI: 10.1016/S0968-0896(00)82141-0  1
1993 Guo JQ, Wu YQ, Farmer WL, Douglas KA, Woster PM, Garofalo J, Basshi CJ. Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents Bioorganic and Medicinal Chemistry Letters. 3: 147-152. DOI: 10.1016/S0960-894X(01)80865-9  1
1993 Wu YQ, Lawrence T, Guo JQ, Woster PM. α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase Bioorganic and Medicinal Chemistry Letters. 3: 2811-2816. DOI: 10.1016/S0960-894X(01)80770-8  1
1992 Wu Y, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase. Journal of Medicinal Chemistry. 35: 3196-201. PMID 1507205 DOI: 10.1021/Jm00095A015  1
1991 Douglas KA, Zormeier MM, Marcolina LM, Woster PM. Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of polyamine biosynthesis Bioorganic and Medicinal Chemistry Letters. 1: 267-270. DOI: 10.1016/S0960-894X(01)81040-4  1
1989 Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026  1
1989 Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026  1
1986 Woster PM, Murray WJ. Synthesis and biological evaluation of cyclic analogues of 1-carnitine as potential agents in the treatment of myocardial ischemia. Journal of Medicinal Chemistry. 29: 865-8. PMID 3084787 DOI: 10.1021/Jm00155A045  1
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