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Patrick M. Woster - Publications

Affiliations: 
Medical University of South Carolina, Charleston, SC, United States 
Area:
Medicinal Chemistry
Website:
https://www.sccp.sc.edu/Patrick-Woster

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Xu JX, Xu FZ, Furbish A, Peterson YK, Woster PM, Braxton AM. Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection. Journal of Visualized Experiments : Jove. PMID 39158296 DOI: 10.3791/66053  0.747
2024 Xu JX, Coker A, Dulaney Z, Furbish A, Xu FZ, Helke KL, Woster PM, Nietert PJ, Braxton AM. Establishing New Isosexual Pairs in Adult Male Guinea Pigs ( to Facilitate Social Housing. Journal of the American Association For Laboratory Animal Science : Jaalas. PMID 38262624 DOI: 10.30802/AALAS-JAALAS-23-000086  0.745
2023 Mills CM, Benton TZ, Piña I, Francis MJ, Reyes L, Dolloff NG, Peterson YK, Woster PM. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical Science. 14: 2168-2182. PMID 36845935 DOI: 10.1039/d2sc05749b  0.8
2022 Mills CM, Turner J, Piña IC, Garrabrant KA, Geerts D, Bachmann AS, Peterson YK, Woster PM. Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. European Journal of Medicinal Chemistry. 244: 114818. PMID 36223680 DOI: 10.1016/j.ejmech.2022.114818  0.818
2022 Furbish AB, Alford AS, Burger P, Peterson YK, Murray-Stewart T, Casero RA, Woster PM. Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Medical Sciences (Basel, Switzerland). 10. PMID 36135832 DOI: 10.3390/medsci10030047  0.826
2022 Reader J, Opperman D, van der Watt M, Theron A, Leshabane M, da Rocha S, Turner J, Garrabrant K, Piña I, Mills C, Woster P, Birkholtz LM. New Transmission-Selective Antimalarial Agents through Hit-To-Lead Optimization of 2-([1,1'-biphenyl]-4-carboxamido)benzoic acid Derivatives. Chembiochem : a European Journal of Chemical Biology. PMID 36106425 DOI: 10.1002/cbic.202200427  0.799
2022 Beck TC, Springs K, Morningstar JE, Mills C, Stoddard A, Guo L, Moore K, Gensemer C, Biggs R, Petrucci T, Kwon J, Stayer K, Koren N, Dunne J, Fulmer D, ... ... Woster P, et al. Application of Pharmacokinetic Prediction Platforms in the Design of Optimized Anti-Cancer Drugs. Molecules (Basel, Switzerland). 27. PMID 35744803 DOI: 10.3390/molecules27123678  0.617
2022 Heslop KA, Burger P, Kappler C, Solanki AK, Gooz M, Peterson YK, Mills C, Benton T, Duncan SA, Woster PM, Maldonado EN. Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 150: 112928. PMID 35447542 DOI: 10.1016/j.biopha.2022.112928  0.774
2021 Benton TZ, Mills CM, Turner JM, Francis MJ, Solomon DJ, Burger PB, Peterson YK, Dolloff NG, Bachmann AS, Woster PM. Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation. Rsc Advances. 11: 33260-33270. PMID 35497564 DOI: 10.1039/d1ra06266b  0.783
2020 Holshouser S, Cafiero R, Robinson M, Kirkpatrick J, Casero RA, Hyacinth HI, Woster PM. Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. Acs Omega. 5: 14750-14758. PMID 32596612 DOI: 10.1021/acsomega.0c01585  0.801
2020 Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, et al. Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. PMID 32350444 DOI: 10.1038/S41388-020-1304-6  0.758
2019 Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA, Woster PM. Dual inhibitors of LSD1 and spermine oxidase. Medchemcomm. 10: 778-790. PMID 31191868 DOI: 10.1039/C8Md00610E  0.82
2019 El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM. Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations. Frontiers in Cellular and Infection Microbiology. 9: 9. PMID 30838177 DOI: 10.3389/Fcimb.2019.00009  0.458
2018 Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA. Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. Plos One. 13: e0202677. PMID 30138353 DOI: 10.1371/Journal.Pone.0202677  0.418
2018 Kirkpatrick JE, Kirkwood KL, Woster PM. Inhibition of the Histone Demethylase KDM4B Leads to Activation of KDM1A, Attenuates Bacterial-Induced Pro-Inflammatory Cytokine Release, and Reduces Osteoclastogenesis. Epigenetics. PMID 29927684 DOI: 10.1080/15592294.2018.1481703  0.641
2018 Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612]. Bioorganic & Medicinal Chemistry. PMID 29859749 DOI: 10.1016/J.Bmc.2018.05.032  0.765
2018 Kumarasinghe IR, Woster PM. Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. European Journal of Medicinal Chemistry. 148: 210-220. PMID 29459279 DOI: 10.1016/J.Ejmech.2018.01.098  0.446
2016 Murray-Stewart TR, Woster PM, Casero RA. Targeting polyamine metabolism for cancer therapy and prevention. The Biochemical Journal. 473: 2937-53. PMID 27679855 DOI: 10.1042/Bcj20160383  0.301
2016 Wang B, Pachaiyappan B, Gruber JD, Schmidt MG, Zhang Y, Woster PM. Antibacterial Diamines Targeting Bacterial Membranes. Journal of Medicinal Chemistry. PMID 26964758 DOI: 10.1021/Acs.Jmedchem.5B01912  0.314
2016 Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Epigenetics: Novel Therapeutics Targeting Epigenetics. Journal of Medicinal Chemistry. PMID 26824165 DOI: 10.1021/Acs.Jmedchem.6B00098  0.355
2015 Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group. Medchemcomm. 6: 613-618. PMID 26005563 DOI: 10.1039/C4Md00401A  0.723
2015 Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorganic & Medicinal Chemistry. 23: 1601-12. PMID 25725609 DOI: 10.1016/J.Bmc.2015.01.049  0.802
2015 Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of Biological Chemistry. 290: 9812-22. PMID 25713082 DOI: 10.1074/Jbc.M114.616219  0.301
2015 Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorganic & Medicinal Chemistry. 23: 5131-43. PMID 25684422 DOI: 10.1016/J.Bmc.2015.01.036  0.414
2015 Cafiero RM, Holshouser S, Kutz C, Kanter J, Woster P. Novel Epigenetic Modulators That Promote Fetal Hemoglobin Production for the Prevention of Sickle Cell Disease Related Complications Blood. 126: 973-973. DOI: 10.1182/Blood.V126.23.973.973  0.795
2015 Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group Medchemcomm. 6: 613-618. DOI: 10.1039/c4md00401a  0.63
2014 Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. Medchemcomm. 5: 1863-1870. PMID 25580204 DOI: 10.1039/C4Md00283K  0.822
2014 Kumarasinghe IR, Woster PM. Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. Acs Medicinal Chemistry Letters. 5: 29-33. PMID 24883177 DOI: 10.1021/Ml4002997  0.451
2014 Pachaiyappan B, Woster PM. Design of small molecule epigenetic modulators Bioorganic and Medicinal Chemistry Letters. 24: 21-32. PMID 24300735 DOI: 10.1016/J.Bmcl.2013.11.001  0.378
2014 Hayes CS, DeFeo-Mattox K, Woster PM, Gilmour SK. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids. 46: 543-552. PMID 23884694 DOI: 10.1007/S00726-013-1559-0  0.302
2014 Murray-Stewart T, Woster PM, Casero RA. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines Amino Acids. 46: 585-594. PMID 23508577 DOI: 10.1007/S00726-013-1485-1  0.444
2014 Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors Medchemcomm. 5: 1863-1870. DOI: 10.1039/c4md00283k  0.803
2013 Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Molecular Cancer Therapeutics. 12: 2088-2099. PMID 23943804 DOI: 10.1158/1535-7163.Mct-13-0418  0.436
2013 Nowotarski SL, Woster PM, Casero RA. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Reviews in Molecular Medicine. 15: e3. PMID 23432971 DOI: 10.1017/Erm.2013.3  0.33
2013 Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner Biochemical Journal. 449: 459-468. PMID 23072722 DOI: 10.1042/Bj20121360  0.373
2013 Woster PM. Synthetic small molecule epigenetic modulators as antitumor agents Medicinal Chemistry. DOI: 10.4172/2161-0444.S1.009  0.361
2012 Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators. Medchemcomm. 3: 14-21. PMID 23293738 DOI: 10.1039/C1Md00220A  0.811
2012 Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA, Woster PM. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1 Journal of Medicinal Chemistry. 55: 7378-7391. PMID 22876979 DOI: 10.1021/Jm3002845  0.516
2012 Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 421: 413-417. PMID 22469467 DOI: 10.1016/J.Bbrc.2012.03.096  0.513
2012 Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA, Marton L, Woster P, Minden MD, Dugas M, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Medicine. 18: 605-11. PMID 22406747 DOI: 10.1038/Nm.2661  0.386
2012 Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 42: 529-38. PMID 21814790 DOI: 10.1007/S00726-011-1030-Z  0.386
2012 Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids. 42: 887-98. PMID 21805138 DOI: 10.1007/S00726-011-1004-1  0.364
2012 Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TMD, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators Medchemcomm. 3: 14-21. DOI: 10.1039/c1md00220a  0.764
2011 Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ. Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. The Journal of Biological Chemistry. 286: 43301-12. PMID 22025614 DOI: 10.1074/Jbc.M111.307835  0.314
2011 Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM. Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities Journal of Medicinal Chemistry. 54: 6624-6633. PMID 21882831 DOI: 10.1021/jm200463z  0.309
2011 Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 15354-9. PMID 21876161 DOI: 10.1073/Pnas.1010203108  0.317
2011 Woster PM. Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 720: 475-491. PMID 21318894 DOI: 10.1007/978-1-61779-034-8_31  0.453
2011 Schenk T, Göllner S, Chen WC, Howell L, Jin L, Hebestreit K, Klein H, Burnett AK, Mills KI, Marton L, Casero R, Woster P, Dugas M, Wang JC, Dick JE, et al. Histone H3 Methylation Mediates All-Trans-Retinoic Acid Responsiveness in Acute Myeloid Leukemia Blood. 118: 224-224. DOI: 10.1182/Blood.V118.21.224.224  0.407
2010 Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA, Mariottini P. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm Bmc Cancer. 10. PMID 20946629 DOI: 10.1186/1471-2407-10-555  0.325
2010 Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. (Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators Journal of Medicinal Chemistry. 53: 5197-5212. PMID 20568780 DOI: 10.1021/Jm100217A  0.663
2010 Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents Journal of Medicinal Chemistry. 53: 4234-4247. PMID 20438064 DOI: 10.1021/Jm100233B  0.81
2010 Lee SB, Park JH, Woster PM, Casero RA, Park MH. Suppression of exogenous gene expression by spermidine/spermine N 1-acetyltransferase 1 (SSAT1) cotransfection Journal of Biological Chemistry. 285: 15548-15556. PMID 20212040 DOI: 10.1074/Jbc.M109.092007  0.335
2010 Pledgie-Tracy A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA, Davidson NE. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemotherapy and Pharmacology. 65: 1067-81. PMID 19727732 DOI: 10.1007/S00280-009-1112-8  0.339
2010 Wu Y, Marton LJ, Woster PM, Casero RA. Abstract 4884: Polyamine analogues in combination with DFMO inhibits lysine-specific demethylase 1 and induces re-expression of aberrantly silenced genes Cancer Research. 70: 4884-4884. DOI: 10.1158/1538-7445.Am10-4884  0.426
2010 Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Abstract 4877: Polyamine analogues modulate gene expression by inhibiting KDM1/LSD1 and altering chromatin structure in human breast cancer cells Cancer Research. 70: 4877-4877. DOI: 10.1158/1538-7445.Am10-4877  0.374
2010 Woster PM. Epigenetic Targets and Cancer Drug Discovery Annual Reports in Medicinal Chemistry. 45: 245-260. DOI: 10.1016/S0065-7743(10)45015-0  0.453
2009 Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells Journal of Cellular and Molecular Medicine. 13: 1877-1885. PMID 20141611 DOI: 10.1111/J.1582-4934.2009.00672.X  0.771
2009 Huang Y, Marton LJ, Woster PM, Casero RA. Polyamine analogues targeting epigenetic gene regulation Essays in Biochemistry. 46: 95-110. PMID 20095972 DOI: 10.1042/Bse0460007  0.489
2009 Senanayake MDT, Amunugama H, Boncher TD, Casero RA, Woster PM. Design of polyamine-based therapeutic agents: New targets and new directions Essays in Biochemistry. 46: 77-94. PMID 20095971 DOI: 10.1042/Bse0460006  0.798
2009 Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7217-28. PMID 19934284 DOI: 10.1158/1078-0432.Ccr-09-1293  0.406
2009 Casero RA, Woster PM. Recent advances in the development of polyamine analogues as antitumor agents Journal of Medicinal Chemistry. 52: 4551-4573. PMID 19534534 DOI: 10.1021/Jm900187V  0.437
2009 Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts Biochemical Journal. 422: 101-109. PMID 19473115 DOI: 10.1042/Bj20090411  0.347
2008 Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes Cancer Research. 68: 2214-2222. PMID 18381427 DOI: 10.1158/0008-5472.Can-07-5030  0.345
2008 Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA, Woster PM. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors Journal of Medicinal Chemistry. 51: 2447-2456. PMID 18348516 DOI: 10.1021/Jm701384X  0.813
2007 Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proceedings of the National Academy of Sciences of the United States of America. 104: 8023-8. PMID 17463086 DOI: 10.1073/Pnas.0700720104  0.401
2007 Boncher T, Bi X, Varghese S, Casero RA, Woster PM. Polyamine-based analogues as biochemical probes and potential therapeutics Biochemical Society Transactions. 35: 356-363. PMID 17371278 DOI: 10.1042/Bst0350356  0.83
2006 Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity Bioorganic and Medicinal Chemistry Letters. 16: 3229-3232. PMID 16616495 DOI: 10.1016/J.Bmcl.2006.03.048  0.396
2006 Woster PM. A Review of: “Evaluation of Enzyme Inhibitors in Drug Discovery” Drug Development and Industrial Pharmacy. 32: 399-400. DOI: 10.1080/03639040500519466  0.339
2005 Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA. Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of Cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines Journal of Biological Chemistry. 280: 39843-39851. PMID 16207710 DOI: 10.1074/Jbc.M508177200  0.376
2005 Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA, Woster PM. Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors Journal of Medicinal Chemistry. 48: 6350-6365. PMID 16190761 DOI: 10.1021/Jm0505009  0.829
2005 Huang Y, Pledgie A, Rubin E, Marton LJ, Woster PM, Sukumar S, Casero RA, Davidson NE. Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells Cancer Biology and Therapy. 4: 1006-1013. PMID 16131835 DOI: 10.4161/Cbt.4.9.1970  0.388
2005 Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): Potential role in determining drug sensitivity Cancer Chemotherapy and Pharmacology. 56: 83-90. PMID 15791459 DOI: 10.1007/S00280-004-0936-5  0.379
2005 Wang Y, Hacker A, Murray-Stewart T, Fleischer JG, Woster PM, Casero RA. Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. The Biochemical Journal. 386: 543-7. PMID 15496143 DOI: 10.1042/Bj20041084  0.355
2004 Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M. Polyamine metabolism in a member of the phylum microspora (Encephalitozoon cuniculi): Effects of polyamine analogues Microbiology. 150: 1215-1224. PMID 15133083 DOI: 10.1099/Mic.0.26889-0  0.402
2003 Devereux W, Wang Y, Stewart TM, Hacker A, Smith R, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Ward TD, Woster PM, Casero RA. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemotherapy and Pharmacology. 52: 383-90. PMID 12827295 DOI: 10.1007/S00280-003-0662-4  0.787
2003 Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO Biochemical and Biophysical Research Communications. 304: 605-611. PMID 12727196 DOI: 10.1016/S0006-291X(03)00636-3  0.349
2003 Casero RA, Wang Y, Stewart TM, Devereux W, Hacker A, Wang Y, Smith R, Woster PM. The role of polyamine catabolism in anti-tumour drug response. Biochemical Society Transactions. 31: 361-5. PMID 12653639 DOI: 10.1042/Bst0310361  0.408
2002 Fraser AV, Woster PM, Wallace HM. Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite. The Biochemical Journal. 367: 307-12. PMID 12086584 DOI: 10.1042/Bj20020156  0.431
2001 Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Research. 61: 5370-3. PMID 11454677  0.314
2001 Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA, Weiss LM, Rattendi D, Lane S, Bacchi CJ. Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity Bioorganic and Medicinal Chemistry Letters. 11: 1613-1617. PMID 11412992 DOI: 10.1016/S0960-894X(01)00315-8  0.405
2001 Casero JA, Woster PM. Terminally alkylated polyamine analogues as chemotherapeutic agents Journal of Medicinal Chemistry. 44: 1-26. PMID 11141084 DOI: 10.1021/Jm000084M  0.389
2001 Woster PM. Chapter 10. New therapies for parasitic infection Annual Reports in Medicinal Chemistry. 36: 99-108. DOI: 10.1016/S0065-7743(01)36050-5  0.343
2000 Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. The Journal of Investigative Dermatology. 114: 1164-73. PMID 10844561 DOI: 10.1046/J.1523-1747.2000.00985.X  0.32
2000 Iyer R, Wu Z, Woster PM, Delcour AH. Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. Journal of Molecular Biology. 297: 933-45. PMID 10736228 DOI: 10.1006/Jmbi.2000.3599  0.363
2000 Nairn LM, Lindsay GS, Woster PM, Wallace HM. Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. Journal of Cellular Physiology. 182: 209-13. PMID 10623884 DOI: 10.1002/(Sici)1097-4652(200002)182:2<209::Aid-Jcp9>3.0.Co;2-8  0.405
1999 Davidson NE, Hahm HA, McCloskey DE, Woster PM, Casero RA. Clinical aspects of cell death in breast cancer: The polyamine pathway as a new target for treatment Endocrine-Related Cancer. 6: 69-73. PMID 10732790 DOI: 10.1677/Erc.0.0060069  0.33
1999 Webb HK, Wu Z, Sirisoma N, Ha HC, Casero RA, Woster PM. 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple synthetic polyamine analogues that differentially alter tubulin polymerization Journal of Medicinal Chemistry. 42: 1415-1421. PMID 10212127 DOI: 10.1021/Jm980603+  0.395
1998 Reilly TP, Bellevue FH, Woster PM, Svensson CK. Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone Biochemical Pharmacology. 55: 803-810. PMID 9586952 DOI: 10.1016/S0006-2952(97)00547-9  0.313
1998 Woster PM, Aoyama T, Satoh T, Yonemato M, Shibata J, Nonoshita K, Arai S, Kawakami K, Iwasawa Y, Sano H, Tanaka K, Monden Y, Kodera T, Arakawa H, Suzuki-Takahashi I, et al. A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyl transferase Chemtracts. 11: 840-844.  0.304
1997 Ha HC, Woster PM, Yager JD, Casero RA. The role of polyamine catabolism in polyamine analogue-induced programmed cell death Proceedings of the National Academy of Sciences of the United States of America. 94: 11557-11562. PMID 9326648 DOI: 10.1073/Pnas.94.21.11557  0.399
1997 Bellevue FH, Woster PM, Edwards DJ, He K, Hollenberg PF. Synthesis and biological evaluation of 6',7'-dihydroxybergamottin (6,7-DHB, a naturally occurring inhibitor of cytochrome P450 3A4 Bioorganic and Medicinal Chemistry Letters. 7: 2593-2598. DOI: 10.1016/S0960-894X(97)10043-9  0.348
1996 Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase Bioorganic and Medicinal Chemistry. 4: 825-836. PMID 8818232 DOI: 10.1016/0968-0896(96)00072-7  0.825
1996 Bellevue FH, Boahbedason M, Wu R, Woster PM, Casero RA, Rattendi D, Lane S, Bacchi CJ. Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity Bioorganic and Medicinal Chemistry Letters. 6: 2765-2770. DOI: 10.1016/S0960-894X(96)00510-0  0.707
1995 Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM. S-(5′-deoxy-5′-adenosyl)-1-aminoxy-4-(methylsulfonio)-2- cyclopentene (AdoMao): An irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity Journal of Medicinal Chemistry. 38: 1770-1777. PMID 7752200 DOI: 10.1021/Jm00010A021  0.468
1995 Wu YQ, Woster PM. Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac) Biochemical Pharmacology. 49: 1125-1133. PMID 7748194 DOI: 10.1016/0006-2952(95)98510-G  0.503
1995 Casero RA, Mank AR, Saab NH, Wu R, Dyer WJ, Woster PM. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemotherapy and Pharmacology. 36: 69-74. PMID 7720179 DOI: 10.1007/Bf00685735  0.794
1995 Felschow DM, MacDiarmid J, Bardos T, Wu R, Woster PM, Porter CW. Photoaffinity labeling of a cell surface polyamine binding protein Journal of Biological Chemistry. 270: 28705-28711. PMID 7499391 DOI: 10.1074/Jbc.270.48.28705  0.651
1994 Vage C, Saab N, Woster PM, Svensson CK. Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood. Toxicology and Applied Pharmacology. 129: 309-16. PMID 7992320 DOI: 10.1006/Taap.1994.1255  0.664
1993 Saab NH, West EE, Bieszk NC, Preuss CV, Mank AR, Casero RA, Woster PM. Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. Journal of Medicinal Chemistry. 36: 2998-3004. PMID 8411017 DOI: 10.1021/Jm00072A020  0.751
1993 Wu YQ, Woster PM. Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli. Bioorganic & Medicinal Chemistry. 1: 349-60. PMID 8081865 DOI: 10.1016/S0968-0896(00)82141-0  0.502
1993 Guo JQ, Wu YQ, Farmer WL, Douglas KA, Woster PM, Garofalo J, Basshi CJ. Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents Bioorganic and Medicinal Chemistry Letters. 3: 147-152. DOI: 10.1016/S0960-894X(01)80865-9  0.593
1993 Wu YQ, Lawrence T, Guo JQ, Woster PM. α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase Bioorganic and Medicinal Chemistry Letters. 3: 2811-2816. DOI: 10.1016/S0960-894X(01)80770-8  0.539
1992 Wu Y, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase. Journal of Medicinal Chemistry. 35: 3196-201. PMID 1507205 DOI: 10.1021/Jm00095A015  0.41
1991 Douglas KA, Zormeier MM, Marcolina LM, Woster PM. Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of polyamine biosynthesis Bioorganic and Medicinal Chemistry Letters. 1: 267-270. DOI: 10.1016/S0960-894X(01)81040-4  0.398
1989 Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026  0.628
1989 Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026  0.65
1986 Woster PM, Murray WJ. Synthesis and biological evaluation of cyclic analogues of 1-carnitine as potential agents in the treatment of myocardial ischemia. Journal of Medicinal Chemistry. 29: 865-8. PMID 3084787 DOI: 10.1021/Jm00155A045  0.581
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