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Anthony E. Pegg - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
Animal Physiology Biology, Molecular Biology, Biochemistry
Website:
https://profiles.psu.edu/profiles/display/112516
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Year Citation  Score
2016 Pegg AE. Functions of polyamines in mammals. The Journal of Biological Chemistry. PMID 27268251 DOI: 10.1074/Jbc.R116.731661  0.35
2014 Pegg AE. The function of spermine. Iubmb Life. 66: 8-18. PMID 24395705 DOI: 10.1002/Iub.1237  0.355
2013 Pegg AE. Toxicity of polyamines and their metabolic products. Chemical Research in Toxicology. 26: 1782-800. PMID 24224555 DOI: 10.1021/Tx400316S  0.343
2013 Chowdhury G, Cho SH, Pegg AE, Guengerich FP. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Angewandte Chemie (International Ed. in English). 52: 12879-82. PMID 24130045 DOI: 10.1002/Anie.201307580  0.358
2013 Peterson LA, Urban AM, Vu CC, Cummings ME, Brown LC, Warmka JK, Li L, Wattenberg EV, Patel Y, Stram DO, Pegg AE. Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chemical Research in Toxicology. 26: 1464-73. PMID 24066836 DOI: 10.1021/Tx400196J  0.367
2013 Kotandeniya D, Murphy D, Yan S, Park S, Seneviratne U, Koopmeiners JS, Pegg A, Kanugula S, Kassie F, Tretyakova N. Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase. Biochemistry. 52: 4075-88. PMID 23683164 DOI: 10.1021/Bi4004952  0.379
2013 Tretyakova NY, Michaelson-Richie ED, Gherezghiher TB, Kurtz J, Ming X, Wickramaratne S, Campion M, Kanugula S, Pegg AE, Campbell C. DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. Biochemistry. 52: 3171-81. PMID 23566219 DOI: 10.1021/Bi400273M  0.392
2013 Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E. Enhancing human spermine synthase activity by engineered mutations. Plos Computational Biology. 9: e1002924. PMID 23468611 DOI: 10.1371/Journal.Pcbi.1002924  0.314
2013 Koomoa DL, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. International Journal of Oncology. 42: 1219-28. PMID 23440295 DOI: 10.3892/Ijo.2013.1835  0.632
2013 Feith DJ, Pegg AE, Fong LY. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis. 34: 570-6. PMID 23222816 DOI: 10.1093/Carcin/Bgs377  0.62
2013 Zhang Z, Pegg A, Ikeguchi Y, Alexov E. Enhancing Human Spermine Synthase Activity by Site Directed Mutations Biophysical Journal. 104: 380a. DOI: 10.1016/J.Bpj.2012.11.2117  0.325
2012 Yamazaki K, Ikeguchi Y, Niwa T, Hayashi K, Iwaki T, Ishii I, Niitsu M, Pegg AE, Shirahata A. Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography. Analytical Sciences : the International Journal of the Japan Society For Analytical Chemistry. 28: 621-4. PMID 22729051 DOI: 10.2116/Analsci.28.621  0.303
2012 Giordano E, Hillary RA, Vary TC, Pegg AE, Sumner AD, Caldarera CM, Zhang XQ, Song J, Wang J, Cheung JY, Shantz LM. Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino Acids. 42: 507-18. PMID 21814794 DOI: 10.1007/S00726-011-1023-Y  0.759
2012 Shi C, Welsh PA, Sass-Kuhn S, Wang X, McCloskey DE, Pegg AE, Feith DJ. Characterization of transgenic mice with overexpression of spermidine synthase. Amino Acids. 42: 495-505. PMID 21809077 DOI: 10.1007/S00726-011-1028-6  0.735
2012 Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg AE, Shirahata A. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids. 42: 619-26. PMID 21809076 DOI: 10.1007/S00726-011-1037-5  0.364
2011 Kotandeniya D, Murphy D, Seneviratne U, Guza R, Pegg A, Kanugula S, Tretyakova N. Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chemical Research in Toxicology. 24: 1966-75. PMID 21913712 DOI: 10.1021/Tx2002993  0.373
2011 Se?kut? J, McCloskey DE, Thomas HJ, Secrist JA, Pegg AE, Ealick SE. Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Science : a Publication of the Protein Society. 20: 1836-44. PMID 21898642 DOI: 10.1002/Pro.717  0.352
2011 Green R, Hanfrey CC, Elliott KA, McCloskey DE, Wang X, Kanugula S, Pegg AE, Michael AJ. Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation. Molecular Microbiology. 81: 1109-24. PMID 21762220 DOI: 10.1111/J.1365-2958.2011.07757.X  0.313
2011 Pegg AE. Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chemical Research in Toxicology. 24: 618-39. PMID 21466232 DOI: 10.1021/Tx200031Q  0.393
2011 Wang X, Pegg AE. Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine. Methods in Molecular Biology (Clifton, N.J.). 720: 159-70. PMID 21318872 DOI: 10.1007/978-1-61779-034-8_9  0.334
2011 Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, Tatsukawa H, Kojima S, Ikeguchi Y, Pegg AE, Kashiwagi K, Igarashi K. Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochemical and Biophysical Research Communications. 404: 1044-9. PMID 21187074 DOI: 10.1016/J.Bbrc.2010.12.107  0.32
2011 Pegg AE, Wang X, Schwartz CE, McCloskey DE. Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine. The Biochemical Journal. 433: 139-44. PMID 20950271 DOI: 10.1042/Bj20101228  0.364
2011 Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser CS, Park MH. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). The Biochemical Journal. 433: 205-13. PMID 20942800 DOI: 10.1042/Bj20101322  0.381
2011 Chuk MK, Cole DE, McCully C, Loktionova NA, Pegg AE, Parker RJ, Pauly G, Widemann BC, Balis FM, Fox E. Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model. Cancer Chemotherapy and Pharmacology. 67: 1291-7. PMID 20725726 DOI: 10.1007/S00280-010-1407-9  0.316
2010 McManus FP, Fang Q, Booth JD, Noronha AM, Pegg AE, Wilds CJ. Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase. Organic & Biomolecular Chemistry. 8: 4414-26. PMID 20714665 DOI: 10.1039/C0Ob00093K  0.383
2010 Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, et al. Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. The Journal of Biological Chemistry. 285: 13736-41. PMID 20212037 DOI: 10.1074/Jbc.M109.093591  0.385
2010 Bale S, Baba K, McCloskey DE, Pegg AE, Ealick SE. Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallographica. Section D, Biological Crystallography. 66: 181-9. PMID 20124698 DOI: 10.1107/S090744490904877X  0.332
2010 Fang Q, Kanugula S, Tubbs JL, Tainer JA, Pegg AE. Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. The Journal of Biological Chemistry. 285: 8185-95. PMID 20026607 DOI: 10.1074/Jbc.M109.045518  0.356
2010 Geerts D, Koster J, Albert D, Koomoa DL, Feith DJ, Pegg AE, Volckmann R, Caron H, Versteeg R, Bachmann AS. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. International Journal of Cancer. 126: 2012-24. PMID 19960435 DOI: 10.1002/Ijc.25074  0.621
2010 Kalapila AG, Pegg AE. Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. Mutation Research. 684: 35-42. PMID 19941875 DOI: 10.1016/J.Mrfmmm.2009.11.006  0.785
2010 Shi C, McCloskey DE, Pegg AE, Feith DJ. Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis Cancer Research. 70: 2483-2483. DOI: 10.1158/1538-7445.Am10-2483  0.739
2009 Pegg AE. S-Adenosylmethionine decarboxylase. Essays in Biochemistry. 46: 25-45. PMID 20095968 DOI: 10.1042/Bse0460003  0.338
2009 Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA. The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chemical Research in Toxicology. 22: 1464-72. PMID 19601657 DOI: 10.1021/Tx9001572  0.381
2009 Casero RA, Pegg AE. Polyamine catabolism and disease. The Biochemical Journal. 421: 323-38. PMID 19589128 DOI: 10.1042/Bj20090598  0.334
2009 Koomoa DL, Borsics T, Feith DJ, Coleman CC, Wallick CJ, Gamper I, Pegg AE, Bachmann AS. Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. Molecular Cancer Therapeutics. 8: 2067-75. PMID 19584241 DOI: 10.1158/1535-7163.Mct-08-1217  0.651
2009 Guza R, Ma L, Fang Q, Pegg AE, Tretyakova N. Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides. The Journal of Biological Chemistry. 284: 22601-10. PMID 19531487 DOI: 10.1074/Jbc.M109.000919  0.375
2009 Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, ... ... Pegg AE, et al. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature. 459: 808-13. PMID 19516334 DOI: 10.1038/Nature08076  0.385
2009 Kalapila AG, Loktionova NA, Pegg AE. Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins. Environmental and Molecular Mutagenesis. 50: 502-14. PMID 19472322 DOI: 10.1002/Em.20491  0.801
2009 Adams CA, Melikishvili M, Rodgers DW, Rasimas JJ, Pegg AE, Fried MG. Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA. Journal of Molecular Biology. 389: 248-63. PMID 19358853 DOI: 10.1016/J.Jmb.2009.03.067  0.74
2009 McCloskey DE, Bale S, Secrist JA, Tiwari A, Moss TH, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. Journal of Medicinal Chemistry. 52: 1388-407. PMID 19209891 DOI: 10.1021/Jm801126A  0.34
2009 Wang X, Levic S, Gratton MA, Doyle KJ, Yamoah EN, Pegg AE. Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. The Journal of Biological Chemistry. 284: 930-7. PMID 19001365 DOI: 10.1074/Jbc.M807758200  0.318
2008 Melikishvili M, Rasimas JJ, Pegg AE, Fried MG. Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs. Biochemistry. 47: 13754-63. PMID 19061338 DOI: 10.1021/Bi801666C  0.743
2008 Bale S, Lopez MM, Makhatadze GI, Fang Q, Pegg AE, Ealick SE. Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry. 47: 13404-17. PMID 19053272 DOI: 10.1021/Bi801732M  0.33
2008 Philip S, Swaminathan S, Kuznetsov SG, Kanugula S, Biswas K, Chang S, Loktionova NA, Haines DC, Kaldis P, Pegg AE, Sharan SK. Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer Research. 68: 9973-81. PMID 19047179 DOI: 10.1158/0008-5472.Can-08-1179  0.381
2008 Pauly GT, Loktionova NA, Fang Q, Vankayala SL, Guida WC, Pegg AE. Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. Journal of Medicinal Chemistry. 51: 7144-53. PMID 18973327 DOI: 10.1021/Jm800675P  0.357
2008 Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 47: 10892-903. PMID 18803403 DOI: 10.1021/Bi8008664  0.376
2008 Kalapila AG, Loktionova NA, Pegg AE. Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. Chemical Research in Toxicology. 21: 1851-61. PMID 18712882 DOI: 10.1021/Tx800178T  0.778
2008 Soriano EV, McCloskey DE, Kinsland C, Pegg AE, Ealick SE. Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii. Acta Crystallographica. Section D, Biological Crystallography. 64: 377-82. PMID 18391404 DOI: 10.1107/S0907444908000474  0.305
2008 Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. The Journal of Biological Chemistry. 283: 16135-46. PMID 18367445 DOI: 10.1074/Jbc.M710323200  0.322
2008 Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. American Journal of Physiology. Endocrinology and Metabolism. 294: E995-1010. PMID 18349109 DOI: 10.1152/Ajpendo.90217.2008  0.386
2008 Loeber R, Michaelson E, Fang Q, Campbell C, Pegg AE, Tretyakova N. Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chemical Research in Toxicology. 21: 787-95. PMID 18324787 DOI: 10.1021/Tx7004508  0.387
2008 Fang Q, Loktionova NA, Moschel RC, Javanmard S, Pauly GT, Pegg AE. Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. Biochemical Pharmacology. 75: 618-26. PMID 17996846 DOI: 10.1016/J.Bcp.2007.09.022  0.351
2007 Coulter R, Blandino M, Tomlinson JM, Pauly GT, Krajewska M, Moschel RC, Peterson LA, Pegg AE, Spratt TE. Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 20: 1966-71. PMID 17975884 DOI: 10.1021/Tx700271J  0.326
2007 Javanmard S, Loktionova NA, Fang Q, Pauly GT, Pegg AE, Moschel RC. Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. Journal of Medicinal Chemistry. 50: 5193-201. PMID 17880193 DOI: 10.1021/Jm0705859  0.351
2007 Deignan JL, Livesay JC, Shantz LM, Pegg AE, O'Brien WE, Iyer RK, Cederbaum SD, Grody WW. Polyamine homeostasis in arginase knockout mice. American Journal of Physiology. Cell Physiology. 293: C1296-301. PMID 17686999 DOI: 10.1152/Ajpcell.00393.2006  0.346
2007 Wang X, Feith DJ, Welsh P, Coleman CS, Lopez C, Woster PM, O'brien TG, Pegg AE. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis Carcinogenesis. 28: 2404-2411. PMID 17675337 DOI: 10.1093/Carcin/Bgm162  0.64
2007 Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and mechanism of spermidine synthases. Biochemistry. 46: 8331-9. PMID 17585781 DOI: 10.1021/Bi602498K  0.303
2007 Tubbs JL, Pegg AE, Tainer JA. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. Dna Repair. 6: 1100-15. PMID 17485252 DOI: 10.1016/J.Dnarep.2007.03.011  0.392
2007 Hansen RJ, Ludeman SM, Paikoff SJ, Pegg AE, Dolan ME. Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. Dna Repair. 6: 1145-54. PMID 17485251 DOI: 10.1016/J.Dnarep.2007.03.010  0.443
2007 Pegg AE, Fang Q, Loktionova NA. Human variants of O6-alkylguanine-DNA alkyltransferase. Dna Repair. 6: 1071-8. PMID 17482892 DOI: 10.1016/J.Dnarep.2007.03.012  0.376
2007 Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero RA. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide Amino Acids. 33: 231-240. PMID 17396215 DOI: 10.1007/S00726-007-0513-4  0.313
2007 Pegg AE, Feith DJ. Polyamines and neoplastic growth. Biochemical Society Transactions. 35: 295-9. PMID 17371264 DOI: 10.1042/Bst0350295  0.638
2007 Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Chemical Research in Toxicology. 20: 155-63. PMID 17226938 DOI: 10.1021/Tx600257G  0.421
2007 Feith DJ, Shantz LM, Shoop PL, Keefer KA, Prakashagowda C, Pegg AE. Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Molecular Carcinogenesis. 46: 453-65. PMID 17219416 DOI: 10.1002/Mc.20294  0.627
2007 Rasimas JJ, Kar SR, Pegg AE, Fried MG. Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs. The Journal of Biological Chemistry. 282: 3357-66. PMID 17138560 DOI: 10.1074/Jbc.M608876200  0.738
2006 Mijal RS, Kanugula S, Vu CC, Fang Q, Pegg AE, Peterson LA. DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. Cancer Research. 66: 4968-74. PMID 16651455 DOI: 10.1158/0008-5472.Can-05-3803  0.386
2006 Guza R, Rajesh M, Fang Q, Pegg AE, Tretyakova N. Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. Chemical Research in Toxicology. 19: 531-8. PMID 16608164 DOI: 10.1021/Tx050348D  0.361
2006 Pegg AE. Regulation of ornithine decarboxylase. The Journal of Biological Chemistry. 281: 14529-32. PMID 16459331 DOI: 10.1074/Jbc.R500031200  0.339
2006 Bewley MC, Graziano V, Jiang J, Matz E, Studier FW, Pegg AE, Coleman CS, Flanagan JM. Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proceedings of the National Academy of Sciences of the United States of America. 103: 2063-8. PMID 16455797 DOI: 10.1073/Pnas.0511008103  0.368
2006 Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Molecular Cancer Therapeutics. 5: 121-8. PMID 16432170 DOI: 10.1158/1535-7163.Mct-05-0236  0.347
2006 Ikeguchi Y, Bewley MC, Pegg AE. Aminopropyltransferases: function, structure and genetics. Journal of Biochemistry. 139: 1-9. PMID 16428313 DOI: 10.1093/Jb/Mvj019  0.346
2006 Nisenberg O, Pegg AE, Welsh PA, Keefer K, Shantz LM. Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. The Biochemical Journal. 393: 295-302. PMID 16153183 DOI: 10.1042/Bj20051196  0.755
2005 Fang Q, Kanugula S, Pegg AE. Function of domains of human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 44: 15396-405. PMID 16285744 DOI: 10.1021/Bi051460D  0.343
2005 Wallick CJ, Gamper I, Thorne M, Feith DJ, Takasaki KY, Wilson SM, Seki JA, Pegg AE, Byus CV, Bachmann AS. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene. 24: 5606-18. PMID 16007177 DOI: 10.1038/Sj.Onc.1208808  0.643
2005 Zang H, Fang Q, Pegg AE, Guengerich FP. Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 280: 30873-81. PMID 16000301 DOI: 10.1074/Jbc.M505283200  0.364
2005 Marverti G, Giuseppina Monti M, Pegg AE, McCloskey DE, Bettuzzi S, Ligabue A, Caporali A, D'Arca D, Moruzzi MS. Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin. Carcinogenesis. 26: 1677-86. PMID 15905201 DOI: 10.1093/Carcin/Bgi129  0.352
2005 Kanugula S, Pauly GT, Moschel RC, Pegg AE. A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities. Proceedings of the National Academy of Sciences of the United States of America. 102: 3617-22. PMID 15731349 DOI: 10.1073/Pnas.0408719102  0.398
2005 Ackermann JM, Kanugula S, Pegg AE. DNAzyme-mediated silencing of ornithine decarboxylase. Biochemistry. 44: 2143-52. PMID 15697240 DOI: 10.1021/Bi047918D  0.781
2004 Thomson NM, Mijal RS, Ziegel R, Fleischer NL, Pegg AE, Tretyakova NY, Peterson LA. Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chemical Research in Toxicology. 17: 1600-6. PMID 15606135 DOI: 10.1021/Tx0498298  0.338
2004 Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. The Journal of Cell Biology. 167: 161-70. PMID 15479742 DOI: 10.1083/Jcb.200312166  0.304
2004 Wang X, Ikeguchi Y, McCloskey DE, Nelson P, Pegg AE. Spermine synthesis is required for normal viability, growth, and fertility in the mouse. The Journal of Biological Chemistry. 279: 51370-5. PMID 15459188 DOI: 10.1074/Jbc.M410471200  0.308
2004 Tantini B, Pignatti C, Fattori M, Fiumana E, Facchini A, Stefanelli C, Caldarera CM, Pegg AE, Flamigni F. Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts. Amino Acids. 27: 207-14. PMID 15378410 DOI: 10.1007/S00726-004-0101-9  0.318
2004 Choi U, DeRavin SS, Yamashita K, Whiting-Theobald N, Linton GF, Loktionova NA, Pegg AE, Malech HL. Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. Experimental Hematology. 32: 709-19. PMID 15308322 DOI: 10.1016/J.Exphem.2004.05.022  0.305
2004 Coleman CS, Stanley BA, Jones AD, Pegg AE. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. The Biochemical Journal. 384: 139-48. PMID 15283699 DOI: 10.1042/Bj20040790  0.353
2004 Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 17: 972-82. PMID 15257623 DOI: 10.1021/Tx049897U  0.376
2004 Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA. DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nature Structural & Molecular Biology. 11: 714-20. PMID 15221026 DOI: 10.1038/Nsmb791  0.792
2004 Liu L, Williams KM, Guengerich FP, Pegg AE. O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. Chemical Research in Toxicology. 17: 742-52. PMID 15206895 DOI: 10.1021/Tx049958O  0.313
2004 Shah R, Coleman CS, Mir K, Baldwin J, Van Etten JL, Grishin NV, Pegg AE, Stanley BA, Phillips MA. Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases. The Journal of Biological Chemistry. 279: 35760-7. PMID 15190062 DOI: 10.1074/Jbc.M405366200  0.33
2004 Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE. Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. The Journal of Biological Chemistry. 279: 33837-46. PMID 15150268 DOI: 10.1074/Jbc.M403369200  0.341
2004 Ikeguchi Y, Wang X, McCloskey DE, Coleman CS, Nelson P, Hu G, Shantz LM, Pegg AE. Characterization of transgenic mice with widespread overexpression of spermine synthase. The Biochemical Journal. 381: 701-7. PMID 15104536 DOI: 10.1042/Bj20040419  0.354
2004 Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein EH, Bickers DR, Athar M. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. The Journal of Clinical Investigation. 113: 867-75. PMID 15067319 DOI: 10.1172/Jci20732  0.653
2004 Coleman CS, Hu G, Pegg AE. Putrescine biosynthesis in mammalian tissues. The Biochemical Journal. 379: 849-55. PMID 14763899 DOI: 10.1042/Bj20040035  0.313
2004 Rasimas JJ, Dalessio PA, Ropson IJ, Pegg AE, Fried MG. Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase. Protein Science : a Publication of the Protein Society. 13: 301-5. PMID 14691244 DOI: 10.1110/Ps.03319404  0.747
2004 Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 279: 4250-9. PMID 14645247 DOI: 10.1074/Jbc.M311105200  0.384
2003 Ackermann JM, Pegg AE, McCloskey DE. Drugs affecting the cell cycle via actions on the polyamine metabolic pathway. Progress in Cell Cycle Research. 5: 461-8. PMID 14593741  0.782
2003 Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. European Journal of Human Genetics : Ejhg. 11: 937-44. PMID 14508504 DOI: 10.1038/Sj.Ejhg.5201072  0.304
2003 Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE. O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry. 42: 10965-70. PMID 12974631 DOI: 10.1021/Bi034937Z  0.375
2003 Kanugula S, Pegg AE. Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus. The Biochemical Journal. 375: 449-55. PMID 12892560 DOI: 10.1042/Bj20030809  0.396
2003 Fong LY, Feith DJ, Pegg AE. Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Research. 63: 3945-54. PMID 12873989  0.623
2003 Ikeguchi Y, Mackintosh CA, McCloskey DE, Pegg AE. Effect of spermine synthase on the sensitivity of cells to anti-tumour agents. The Biochemical Journal. 373: 885-92. PMID 12737625 DOI: 10.1042/Bj20030246  0.351
2003 Hillary RA, Pegg AE. Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide. Biochimica Et Biophysica Acta. 1647: 161-6. PMID 12686127 DOI: 10.1016/S1570-9639(03)00088-8  0.774
2003 Pegg AE, Feith DJ, Fong LY, Coleman CS, O'Brien TG, Shantz LM. Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth. Biochemical Society Transactions. 31: 356-60. PMID 12653638 DOI: 10.1042/Bst0310356  0.647
2003 McCloskey DE, Pegg AE. Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine. The Journal of Biological Chemistry. 278: 13881-7. PMID 12578836 DOI: 10.1074/Jbc.M205689200  0.358
2003 Rasimas JJ, Kanugula S, Dalessio PM, Ropson IJ, Fried MG, Pegg AE. Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 42: 980-90. PMID 12549918 DOI: 10.1021/Bi026970B  0.743
2003 Rasimas JJ, Pegg AE, Fried MG. DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. The Journal of Biological Chemistry. 278: 7973-80. PMID 12496275 DOI: 10.1074/Jbc.M211854200  0.743
2002 Liu L, Pegg AE, Williams KM, Guengerich FP. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 277: 37920-8. PMID 12151404 DOI: 10.1074/Jbc.M205548200  0.406
2002 Luu KX, Kanugula S, Pegg AE, Pauly GT, Moschel RC. Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase. Biochemistry. 41: 8689-97. PMID 12093287 DOI: 10.1021/Bi025857I  0.773
2002 Liu L, Xu-Welliver M, Kanugula S, Pegg AE. Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. Cancer Research. 62: 3037-43. PMID 12036910  0.307
2002 Xu-Welliver M, Pegg AE. Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis. 23: 823-30. PMID 12016156 DOI: 10.1093/Carcin/23.5.823  0.405
2002 Loktionova NA, Pegg AE. Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. Biochemical Pharmacology. 63: 1431-42. PMID 11996884 DOI: 10.1016/S0006-2952(02)00906-1  0.36
2002 Shantz LM, Guo Y, Sawicki JA, Pegg AE, O'Brien TG. Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. Carcinogenesis. 23: 657-64. PMID 11960919 DOI: 10.1093/Carcin/23.4.657  0.325
2002 Coleman CS, Pegg AE, Megosh LC, Guo Y, Sawicki JA, O'Brien TG. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Carcinogenesis. 23: 359-64. PMID 11872645 DOI: 10.1093/Carcin/23.2.359  0.342
2002 Kanugula S, Pegg AE. Novel DNA repair alkyltransferase from Caenorhabditis elegans. Environmental and Molecular Mutagenesis. 38: 235-43. PMID 11746760 DOI: 10.1002/Em.1077  0.39
2002 Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A. The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nature Structural Biology. 9: 27-31. PMID 11731804 DOI: 10.1038/Nsb737  0.329
2001 Tolbert WD, Ekstrom JL, Mathews II, Secrist JA, Kapoor P, Pegg AE, Ealick SE. The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. Biochemistry. 40: 9484-94. PMID 11583147 DOI: 10.1021/Bi010735W  0.357
2001 Feith DJ, Shantz LM, Pegg AE. Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Research. 61: 6073-81. PMID 11507056  0.586
2001 Coleman CS, Pegg AE. Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation Biochemical Journal. 358: 137-145. PMID 11485561 DOI: 10.1042/Bj3580137  0.364
2001 Shantz LM, Feith DJ, Pegg AE. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. The Biochemical Journal. 358: 25-32. PMID 11485548 DOI: 10.1042/0264-6021:3580025  0.626
2001 Bauer PM, Buga GM, Fukuto JM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. The Journal of Biological Chemistry. 276: 34458-64. PMID 11461922 DOI: 10.1074/Jbc.M105219200  0.359
2001 Xu-Welliver M, Pegg AE. Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine. The Biochemical Journal. 347: 519-26. PMID 10749682 DOI: 10.1042/Bj3470519  0.357
2001 STEFANELLI C, PIGNATTI C, TANTINI B, FATTORI M, STANIC I, MACKINTOSH CA, FLAMIGNI F, GUARNIERI C, CALDARERA CM, PEGG AE. Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells Biochemical Journal. 355: 199-206. DOI: 10.1042/0264-6021:3550199  0.326
2000 Lopatin AN, Shantz LM, Mackintosh CA, Nichols CG, Pegg AE. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. Journal of Molecular and Cellular Cardiology. 32: 2007-24. PMID 11040105 DOI: 10.1006/Jmcc.2000.1232  0.3
2000 MacKintosh CA, Pegg AE. Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea Biochemical Journal. 351: 439-447. PMID 11023830 DOI: 10.1042/Bj3510439  0.309
2000 Mackintosh CA, Feith DJ, Shantz LM, Pegg AE. Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy. The Biochemical Journal. 350: 645-53. PMID 10970775 DOI: 10.1042/Bj3500645  0.642
2000 Liu H, Xu-Welliver M, Pegg AE. The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli. Mutation Research. 452: 1-10. PMID 10894884 DOI: 10.1016/S0027-5107(00)00062-2  0.409
2000 McCloskey DE, Pegg AE. Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues Journal of Biological Chemistry. 275: 28708-28714. PMID 10887189 DOI: 10.1074/Jbc.M004120200  0.325
2000 Pegg AE. Repair of O6-alkylguanine by alkyltransferases Mutation Research - Reviews in Mutation Research. 462: 83-100. PMID 10767620 DOI: 10.1016/S1383-5742(00)00017-X  0.427
2000 Xu-Welliver M, Kanugula S, Loktionova NA, Crone TM, Pegg AE. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine Biochemical Journal. 347: 527-534. PMID 10749683 DOI: 10.1042/0264-6021:3470527  0.439
2000 Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA. Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. The Embo Journal. 19: 1719-30. PMID 10747039 DOI: 10.1093/Emboj/19.7.1719  0.404
2000 Pegg AE. DNA repair pathways and cancer prevention Advances in Experimental Medicine and Biology. 472: 253-267. PMID 10736632 DOI: 10.1007/978-1-4757-3230-6_22  0.352
2000 Olmo MT, Urdiales JL, Pegg AE, Medina MA, Sánchez-Jiménez F. In vitro study of proteolytic degradation of rat histidine decarboxylase. European Journal of Biochemistry. 267: 1527-31. PMID 10691992 DOI: 10.1046/J.1432-1327.2000.01153.X  0.305
2000 Kokkinakis DM, Moschel RC, Pegg AE, Schold SC. Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism. Cancer Chemotherapy and Pharmacology. 45: 69-77. PMID 10647505 DOI: 10.1007/Pl00006746  0.358
2000 Wibley JE, Pegg AE, Moody PC. Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase. Nucleic Acids Research. 28: 393-401. PMID 10606635 DOI: 10.1093/Nar/28.2.393  0.396
2000 XU-WELLIVER M, KANUGULA S, LOKTIONOVA NA, CRONE TM, PEGG AE. Conserved residue lysine165 is essential for the ability of O6-alkylguanine–DNA alkyltransferase to react with O6-benzylguanine Biochemical Journal. 347: 527-534. DOI: 10.1042/bj3470527  0.33
1999 Nutt CL, Loktionova NA, Pegg AE, Chambers AF, Cairncross JG. O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes. Carcinogenesis. 20: 2361-5. PMID 10590234 DOI: 10.1093/Carcin/20.12.2361  0.344
1999 Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Human Gene Therapy. 10: 2769-78. PMID 10584923 DOI: 10.1089/10430349950016500  0.346
1999 Xiong H, Pegg AE. Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate Journal of Biological Chemistry. 274: 35059-35066. PMID 10574985 DOI: 10.1074/Jbc.274.49.35059  0.306
1999 Xu-Welliver M, Leitão J, Kanugula S, Meehan WJ, Pegg AE. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine Biochemical Pharmacology. 58: 1279-1285. PMID 10487529 DOI: 10.1016/S0006-2952(99)00216-6  0.373
1999 Bauer PM, Fukuto JM, Buga GM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation. Biochemical and Biophysical Research Communications. 262: 355-8. PMID 10462479 DOI: 10.1006/Bbrc.1999.1210  0.36
1999 Loktionova NA, Xu-Welliver M, Crone TM, Kanugula S, Pegg AE. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine Biochemical Pharmacology. 58: 237-244. PMID 10423163 DOI: 10.1016/S0006-2952(99)00095-7  0.386
1999 Ekstrom JL, Mathews II, Stanley BA, Pegg AE, Ealick SE. The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold. Structure (London, England : 1993). 7: 583-95. PMID 10378277 DOI: 10.1016/S0969-2126(99)80074-4  0.301
1999 Spratt TE, Wu JD, Levy DE, Kanugula S, Pegg AE. Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 38: 6801-6. PMID 10346901 DOI: 10.1021/Bi982908W  0.363
1999 Shantz LM, Pegg AE. Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway International Journal of Biochemistry and Cell Biology. 31: 107-122. PMID 10216947 DOI: 10.1016/S1357-2725(98)00135-6  0.371
1999 McCloskey DE, Coleman CS, Pegg AE. Properties and regulation of human spermidine/spermine N1-acetyltransferase stably expressed in Chinese hamster ovary cells. The Journal of Biological Chemistry. 274: 6175-82. PMID 10037702 DOI: 10.1074/Jbc.274.10.6175  0.364
1999 Xiong H, Stanley BA, Pegg AE. Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase. Biochemistry. 38: 2462-70. PMID 10029540 DOI: 10.1021/Bi9825201  0.344
1999 Edara S, Kanugula S, Pegg AE. Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 20: 103-8. PMID 9934856 DOI: 10.1093/Carcin/20.1.103  0.374
1999 Friedman HS, Pegg AE, Johnson SP, Loktionova NA, Dolan ME, Modrich P, Moschel RC, Struck R, Brent TP, Ludeman S, Bullock N, Kilborn C, Keir S, Dong Q, Bigner DD, et al. Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. Cancer Chemotherapy and Pharmacology. 43: 80-5. PMID 9923545 DOI: 10.1007/S002800050866  0.399
1999 Goodtzova K, Kanugula S, Edara S, Pegg AE. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase. Biochemistry. 37: 12489-95. PMID 9730821 DOI: 10.1021/Bi9811718  0.437
1998 Pegg AE, Xiong H, Feith DJ, Shantz LM. S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines. Biochemical Society Transactions. 26: 580-6. PMID 10047786 DOI: 10.1042/Bst0260580  0.594
1998 Friedman HS, Kokkinakis DM, Pluda J, Friedman AH, Cokgor I, Haglund MM, Ashley DM, Rich J, Dolan ME, Pegg AE, Moschel RC, McLendon RE, Kerby T, Herndon JE, Bigner DD, et al. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 16: 3570-5. PMID 9817277 DOI: 10.1200/Jco.1998.16.11.3570  0.323
1998 Matés JM, del Valle AE, Urdiales JL, Coleman CS, Feith D, Olmo MT, Pegg AE, Sánchez-Jiménez F. Structure/function relationship studies on the T/S residues 173-177 of rat ODC. Biochimica Et Biophysica Acta. 1386: 113-20. PMID 9675257 DOI: 10.1016/S0167-4838(98)00090-9  0.633
1998 Vora RA, Pegg AE, Ealick SE. A new model for how O6-methylguanine-DNA methyltransferase binds DNA Proteins: Structure, Function and Genetics. 32: 3-6. PMID 9672037 DOI: 10.1002/(Sici)1097-0134(19980701)32:1<3::Aid-Prot2>3.0.Co;2-O  0.362
1998 Dolan ME, Roy SK, Garbiras BJ, Helft P, Paras P, Chae MY, Moschel RC, Pegg AE. O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases Biochemical Pharmacology. 55: 1701-1709. PMID 9634007 DOI: 10.1016/S0006-2952(98)00047-1  0.381
1998 Pegg AE, Kanugula S, Edara S, Pauly GT, Moschel RC, Goodtzova K. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides. The Journal of Biological Chemistry. 273: 10863-7. PMID 9556560 DOI: 10.1074/Jbc.273.18.10863  0.365
1998 Pegg A. An encyclopedia of polyamines Trends in Biochemical Sciences. 23: 366-367. DOI: 10.1016/S0968-0004(98)01275-4  0.345
1997 Xiong H, Stanley BA, Tekwani BL, Pegg AE. Processing of mammalian and plant S-adenosylmethionine decarboxylase proenzymes. The Journal of Biological Chemistry. 272: 28342-8. PMID 9353291 DOI: 10.1074/Jbc.272.45.28342  0.302
1997 Pegg AE, Chung L, Moschel RC. Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives. Biochemical Pharmacology. 53: 1559-64. PMID 9260884 DOI: 10.1016/S0006-2952(97)00060-9  0.377
1997 Hazra TK, Roy R, Biswas T, Grabowski DT, Pegg AE, Mitra S. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase. Biochemistry. 36: 5769-76. PMID 9153417 DOI: 10.1021/Bi963085I  0.304
1997 Colemant CS, Pegg AE. Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues Journal of Biological Chemistry. 272: 12164-12169. PMID 9115288 DOI: 10.1074/Jbc.272.18.12164  0.333
1997 Goodtzova K, Kanugula S, Edara S, Pauly GT, Moschel RC, Pegg AE. Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases. The Journal of Biological Chemistry. 272: 8332-9. PMID 9079656 DOI: 10.1074/Jbc.272.13.8332  0.396
1997 Engel N, Olmo MT, Coleman CS, Medina MA, Pegg AE, Sánchez-Jiménez F. Experimental evidence for structure-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase. The Biochemical Journal. 365-8. PMID 8973541 DOI: 10.1042/Bj3200365  0.318
1996 Fried MG, Kanugula S, Bromberg JL, Pegg AE. DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability. Biochemistry. 35: 15295-301. PMID 8952480 DOI: 10.1021/Bi960971K  0.369
1996 Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase Bioorganic and Medicinal Chemistry. 4: 825-836. PMID 8818232 DOI: 10.1016/0968-0896(96)00072-7  0.341
1996 Coleman CS, Huang H, Pegg AE. Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. The Biochemical Journal. 697-701. PMID 8670140 DOI: 10.1042/Bj3160697  0.36
1996 Crone TM, Goodtzova K, Pegg AE. Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase Mutation Research - Dna Repair. 363: 15-25. PMID 8632775 DOI: 10.1016/0921-8777(95)00058-5  0.369
1996 Pegg AE, Shantz LM, Coleman CS. Ornithine decarboxylase as a target for chemoprevention. Journal of Cellular Biochemistry. Supplement. 22: 132-8. PMID 8538190 DOI: 10.1002/Jcb.240590817  0.395
1995 Dolan ME, Pegg AE, Moschel RC, Vishnuvajjala BR, Flora KP, Grever MR, Friedman HS. Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. Cancer Chemotherapy and Pharmacology. 35: 121-6. PMID 7987987 DOI: 10.1007/Bf00686633  0.34
1995 Parry L, Lopez-Ballester J, Wiest L, Pegg AE. Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli. Biochemistry. 34: 2701-9. PMID 7873553 DOI: 10.1021/Bi00008A038  0.367
1995 Parry L, Balaña Fouce R, Pegg AE. Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine. The Biochemical Journal. 451-8. PMID 7832759 DOI: 10.1042/Bj3050451  0.321
1995 Chae MY, Swenn K, Kanugula S, Dolan ME, Pegg AE, Moschel RC. 8-substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase Journal of Medicinal Chemistry. 38: 359-365. PMID 7830279 DOI: 10.1021/Jm00002A018  0.359
1995 Kanugula S, Goodtzova K, Edara S, Pegg AE. Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine. Biochemistry. 34: 7113-9. PMID 7766621 DOI: 10.1021/Bi00021A024  0.404
1995 Pegg AE, Hu RH. Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation Cancer Letters. 95: 247-252. PMID 7656239 DOI: 10.1016/0304-3835(95)03897-6  0.308
1995 Pegg AE, Poulin R, Coward JK. Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function. The International Journal of Biochemistry & Cell Biology. 27: 425-42. PMID 7641073 DOI: 10.1016/1357-2725(95)00007-C  0.358
1995 Crone TM, Knaugula S, Pegg AE. Mutations in the ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine Carcinogenesis. 16: 1687-1692. PMID 7634390 DOI: 10.1093/Carcin/16.8.1687  0.368
1995 Edara S, Goodtzova K, Pegg AE. The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity. Carcinogenesis. 16: 1637-42. PMID 7614699 DOI: 10.1093/Carcin/16.7.1637  0.418
1995 Coleman CS, Huang H, Pegg AE. Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine. Biochemistry. 34: 13423-30. PMID 7577929 DOI: 10.1021/Bi00041A020  0.336
1995 Pegg AE, Swenn K, Chae MY, Dolan ME, Moschel RC. Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea. Biochemical Pharmacology. 50: 1141-8. PMID 7488227 DOI: 10.1016/0006-2952(95)00249-Y  0.361
1994 Chae MY, McDougall MG, Eileen Dolan M, Swenn K, Pegg AE, Moschel RC. Substituted o6-benzylguanine derivatives and their inactivation of human o6-alkylguanine-dna alkyltransferase Journal of Medicinal Chemistry®. 37: 342-347. PMID 8308861 DOI: 10.1021/Jm00029A005  0.365
1994 Sarkar A, Dolan ME, Gonzalez GG, Marton LJ, Pegg AE, Deen DF. The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells. Cancer Chemotherapy and Pharmacology. 32: 477-81. PMID 8258197 DOI: 10.1007/Bf00685893  0.368
1994 Lijinsky W, Pegg AE, Anver MR, Moschel RC. Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea. Japanese Journal of Cancer Research : Gann. 85: 226-30. PMID 8188519 DOI: 10.1111/J.1349-7006.1994.Tb02086.X  0.367
1994 Goodtzova K, Crone TM, Pegg AE. Activation of human O6-alkylguanine-DNA alkyltransferase by DNA Biochemistry. 33: 8385-8390. PMID 8031773 DOI: 10.1021/Bi00194A001  0.397
1994 Byers TL, Lakanen JR, Coward JK, Pegg AE. The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. The Biochemical Journal. 303: 363-8. PMID 7980394 DOI: 10.1042/Bj3030363  0.319
1994 Byers TL, Wechter RS, Hu RH, Pegg AE. Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures. The Biochemical Journal. 89-96. PMID 7945270 DOI: 10.1042/Bj3030089  0.347
1994 Shantz LM, Viswanath R, Pegg AE. Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine. The Biochemical Journal. 765-72. PMID 7945201 DOI: 10.1042/Bj3020765  0.321
1993 Casero RA, Pegg AE. Spermidine/spermine N1-acetyltransferase - The turning point in polyamine metabolism Faseb Journal. 7: 653-661. PMID 8500690 DOI: 10.1096/Fasebj.7.8.8500690  0.345
1993 Dolan ME, Pegg AE, Biser ND, Moschel RC, English HF. Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer. Cancer Chemotherapy and Pharmacology. 32: 221-5. PMID 8500228 DOI: 10.1007/Bf00685839  0.328
1993 Albanese L, Bergeron RJ, Pegg AE. Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine. The Biochemical Journal. 131-7. PMID 8471032 DOI: 10.1042/Bj2910131  0.349
1993 Pegg AE, Coward JK. Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. Biochemical Pharmacology. 46: 717-24. PMID 8395844 DOI: 10.1016/0006-2952(93)90559-F  0.421
1993 Dolan ME, Pegg AE, Moschel RC, Grindey GB. Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochemical Pharmacology. 46: 285-90. PMID 8347150 DOI: 10.1016/0006-2952(93)90416-T  0.355
1993 Shantz LM, Holm I, Jänne OA, Pegg AE. Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content. The Biochemical Journal. 511-8. PMID 1463454 DOI: 10.1042/Bj2880511  0.355
1993 Friedman HS, Dolan ME, Moschel RC, Pegg AE, Felker GM, Rich J, Bigner DD, Schold SC. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. Journal of the National Cancer Institute. 84: 1926-31. PMID 1334154 DOI: 10.1093/Jnci/84.24.1926  0.368
1992 Shantz LM, Stanley BA, Secrist JA, Pegg AE. Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5′-deoxy-5′-[(3-hydrazinopropyl)methylamino]adenosine and 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine Biochemistry. 31: 6848-6855. PMID 1637820 DOI: 10.1021/Bi00144A027  0.335
1992 Pegg AE, Byers TL. Repair of DNA containing O6-alkylguanine Faseb Journal. 6: 2302-2310. PMID 1544541 DOI: 10.1096/Fasebj.6.6.1544541  0.421
1992 Lakanen JR, Coward JK, Pegg AE. alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. Journal of Medicinal Chemistry. 35: 724-34. PMID 1542099 DOI: 10.1021/Jm00082A013  0.351
1992 Tekwani BL, Bacchi CJ, Secrist JA, Pegg AE. Irreversible inhibition of S-adenosylmethionine decarboxylase of trypanosoma bru cei bru cei by S-adenosylmethionine analogues Biochemical Pharmacology. 44: 905-911. PMID 1530659 DOI: 10.1016/0006-2952(92)90122-Y  0.339
1992 Graves R, Laval J, Pegg AE. Sequence specificity of DNA repair by Escherichia coli Fpg protein. Carcinogenesis. 13: 1455-9. PMID 1499097 DOI: 10.1093/Carcin/13.8.1455  0.363
1992 Tekwani BL, Bacchi CJ, Pegg AE. Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei Molecular and Cellular Biochemistry. 117: 53-61. PMID 1480164 DOI: 10.1007/Bf00230410  0.362
1992 Byers TL, Ganem B, Pegg AE. Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion. The Biochemical Journal. 287: 717-24. PMID 1445235 DOI: 10.1042/Bj2870717  0.355
1992 Pegg AE, McCann PP. S-adenosylmenthionine decarboxylase as an enzyme target for therapy Pharmacology and Therapeutics. 56: 359-377. PMID 1301596 DOI: 10.1016/0163-7258(92)90025-U  0.354
1991 Pegg AE, Nagarajan S, Naficy S, Ganem B. Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells. The Biochemical Journal. 274: 167-71. PMID 2001229 DOI: 10.1042/Bj2740167  0.301
1991 Lukash LL, Boldt J, Pegg AE, Eileen Dolan M, Maher VM, Justin McCormick J. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N′-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 250: 397-409. PMID 1944354 DOI: 10.1016/0027-5107(91)90196-U  0.384
1991 Pegg AE, Wiest L, Mummert C, Stine L, Moschel RC, Dolan ME. Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 12: 1679-83. PMID 1893528 DOI: 10.1093/Carcin/12.9.1679  0.391
1991 Pegg AE, Wiest L, Mummert C, Dolan ME. Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts. Carcinogenesis. 12: 1671-7. PMID 1893527 DOI: 10.1093/Carcin/12.9.1671  0.347
1991 Lu L, Stanley BA, Pegg AE. Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover Biochemical Journal. 277: 671-675. PMID 1872802 DOI: 10.1042/Bj2770671  0.369
1991 Dolan ME, Pegg AE, Dumenco LL, Moschel RC, Gerson SL. Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. Carcinogenesis. 12: 2305-9. PMID 1747932 DOI: 10.1093/Carcin/12.12.2305  0.378
1990 Dolan ME, Larkin GL, English HF, Pegg AE. Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine. Cancer Chemotherapy and Pharmacology. 25: 103-8. PMID 2557168 DOI: 10.1007/Bf00692348  0.379
1990 Porter CW, Pegg AE, Ganis B, Madhabala R, Bergeron RJ. Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine. The Biochemical Journal. 268: 207-12. PMID 2344358 DOI: 10.1042/Bj2680207  0.388
1990 Pegg AE, Pakala R, Bergeron RJ. Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds. The Biochemical Journal. 267: 331-8. PMID 2334396 DOI: 10.1042/Bj2670331  0.377
1990 Casero RA, Celano P, Ervin SJ, Wiest L, Pegg AE. High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. The Biochemical Journal. 270: 615-20. PMID 2241897 DOI: 10.1042/Bj2700615  0.353
1990 Pegg AE. Properties of mammalian O6-alkylguanine-DNA transferases Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 233: 165-175. PMID 2233798 DOI: 10.1016/0027-5107(90)90160-6  0.345
1990 Dolan ME, Moschel RC, Pegg AE. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proceedings of the National Academy of Sciences of the United States of America. 87: 5368-72. PMID 2164681 DOI: 10.1073/Pnas.87.14.5368  0.366
1990 Byers TL, Pegg AE. Regulation of polyamine transport in Chinese hamster ovary cells Journal of Cellular Physiology. 143: 460-467. PMID 2113535 DOI: 10.1002/Jcp.1041430309  0.313
1989 Pegg AE, Kameji T, Shirahata A, Stanley B, Madhubala R, Pajunen A. Regulation of mammalian S-adenosylmethionine decarboxylase. Advances in Enzyme Regulation. 27: 43-55. PMID 3250232 DOI: 10.1016/0065-2571(88)90008-8  0.331
1989 Weisburger JH, Jones RC, Barnes WS, Pegg AE. Mechanisms of differential strain sensitivity in gastric carcinogenesis. Japanese Journal of Cancer Research : Gann. 79: 1304-10. PMID 3148600 DOI: 10.1111/J.1349-7006.1988.Tb01560.X  0.312
1989 Pegg AE, Stanley B, Pajunen A, Crozat A, Jänne OA. Properties of human and rodent S-adenosylmethionine decarboxylase. Advances in Experimental Medicine and Biology. 250: 101-9. PMID 3076317 DOI: 10.1007/978-1-4684-5637-0_10  0.329
1989 Holm I, Persson L, Pegg AE, Heby O. Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells. The Biochemical Journal. 261: 205-10. PMID 2775206 DOI: 10.1042/Bj2610205  0.4
1989 Dolan ME, Norbeck L, Clyde C, Hora NK, Erickson LC, Pegg AE. Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents. Carcinogenesis. 10: 1613-9. PMID 2766456 DOI: 10.1093/Carcin/10.9.1613  0.406
1989 Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026  0.359
1989 Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026  0.348
1989 Poulin R, Secrist JA, Pegg AE. Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells Biochemical Journal. 263: 215-221. PMID 2513802 DOI: 10.1042/Bj2630215  0.329
1989 Byers TL, Wechter R, Nuttall ME, Pegg AE. Expression of a human gene for polyamine transport in Chinese-hamster ovary cells Biochemical Journal. 263: 745-752. PMID 2512913 DOI: 10.1042/Bj2630745  0.32
1989 Kameji R, Rannels SR, Pegg AE, Rannels DE. Spermidine uptake by type II pulmonary epithelial cells in primary culture. The American Journal of Physiology. 256: C160-7. PMID 2463760 DOI: 10.1152/Ajpcell.1989.256.1.C160  0.306
1988 Sertich GJ, Persson L, Pegg AE. Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin. The American Journal of Physiology. 253: C687-92. PMID 3688216 DOI: 10.1152/Ajpcell.1987.253.5.C687  0.336
1988 Pegg AE, Jones DB, Secrist JA. Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells. Biochemistry. 27: 1408-15. PMID 3365395 DOI: 10.1021/Bi00405A003  0.373
1988 Dolan ME, Oplinger M, Pegg AE. Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion Mutation Research Dna Repair Reports. 193: 131-137. PMID 3279309 DOI: 10.1016/0167-8817(88)90043-0  0.329
1988 Dolan ME, Oplinger M, Pegg AE. Sequence specificity of guanine alkylation and repair Carcinogenesis. 9: 2139-2143. PMID 3180351 DOI: 10.1093/Carcin/9.11.2139  0.353
1988 Brent TP, Dolan ME, Fraenkel-Conrat H, Hall J, Karran P, Laval L, Margison GP, Montesano R, Pegg AE, Potter PM. Repair of O-alkylpyrimidines in mammalian cells: a present consensus. Proceedings of the National Academy of Sciences of the United States of America. 85: 1759-62. PMID 3162305 DOI: 10.1073/Pnas.85.6.1759  0.37
1988 Nagarajan S, Ganem B, Pegg AE. Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to alpha-difluoromethylornithine. The Biochemical Journal. 254: 373-8. PMID 3140800 DOI: 10.1042/Bj2540373  0.328
1988 Pegg AE, Morimoto K, Dolan ME. Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase Chemico-Biological Interactions. 65: 275-281. PMID 2454164 DOI: 10.1016/0009-2797(88)90112-3  0.364
1987 Scicchitano DA, Pegg AE. Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals Mutation Research Letters. 192: 207-210. PMID 3683440 DOI: 10.1016/0165-7992(87)90057-1  0.352
1987 Coward JK, Pegg AE. Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells. Advances in Enzyme Regulation. 26: 107-13. PMID 3673702 DOI: 10.1016/0065-2571(87)90008-2  0.341
1987 Pegg AE, Wechter R, Pajunen A. Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine Biochemical Journal. 244: 49-54. PMID 3663117 DOI: 10.1042/Bj2440049  0.369
1987 Kameji T, Pegg AE. Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase Biochemical Journal. 243: 285-288. PMID 3606578 DOI: 10.1042/Bj2430285  0.341
1987 Sertich GJ, Pegg AE. Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content Biochemical and Biophysical Research Communications. 143: 424-430. PMID 3566731 DOI: 10.1016/0006-291X(87)91371-4  0.361
1987 Pegg AE, Eileen Dolan M. Properties and assay of mammalian O6-alkyguanine-DNA alkyltransferase Pharmacology and Therapeutics. 34: 167-179. PMID 3317450 DOI: 10.1016/0163-7258(87)90010-6  0.345
1987 Pegg AE, McGovern KA, Wiest L. Decarboxylation of α-difluoromethylornithine by ornithine decarboxylase Biochemical Journal. 241: 305-307. PMID 3105526 DOI: 10.1042/Bj2410305  0.325
1987 Porter CW, Berger FG, Pegg AE, Ganis B, Bergeron RJ. Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine Biochemical Journal. 242: 433-440. PMID 3036091 DOI: 10.1042/Bj2420433  0.391
1986 Della Ragione F, Porcelli M, Cartenì-Farina M, Zappia V, Pegg AE. Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action. The Biochemical Journal. 232: 335-41. PMID 3911944 DOI: 10.1042/Bj2320335  0.353
1986 Pegg AE, Dolan ME, Scicchitano D, Morimoto K. Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria. Environmental Health Perspectives. 62: 109-14. PMID 3910413 DOI: 10.1289/Ehp.8562109  0.381
1986 Erwin BG, Pegg AE. Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds Biochemical Journal. 238: 581-587. PMID 3800951 DOI: 10.1042/Bj2380581  0.338
1986 Scicchitano D, Jones RA, Kuzmich S, Gaffney B, Lasko DD, Essigmann JM, Pegg AE. Repair of oligodeoxynucleotides containing o-methylguanine by o-alkylguanine-dna-alkyltransferase Carcinogenesis. 7: 1383-1386. PMID 3731392 DOI: 10.1093/Carcin/7.8.1383  0.381
1986 Pegg AE, Coward JK, Talekar RR, Secrist JA. Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase. Biochemistry. 25: 4091-7. PMID 3091070 DOI: 10.1021/Bi00362A016  0.341
1986 McGovern KA, Clark RS, Pegg AE. Effect of 1,3,6-triaminohexane and 1,4,7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine. Journal of Cellular Physiology. 127: 311-6. PMID 3009500 DOI: 10.1002/Jcp.1041270219  0.319
1986 Pegg AE, Wechter RS, Clark RS, Wiest L, Erwin BG. Acetylation of decarboxylated S-adenosylmethionine by mammalian cells. Biochemistry. 25: 379-84. PMID 3006760 DOI: 10.1021/Bi00350A016  0.321
1985 Pegg AE, Coward JK. Growth of mammalian cells in the absence of the accumulation of spermine. Biochemical and Biophysical Research Communications. 133: 82-9. PMID 4074381 DOI: 10.1016/0006-291X(85)91844-3  0.339
1985 Domoradzki J, Pegg AE, Dolan ME, Maher VM, Mccormick JJ. Depletion of o-methylguanine-dna-methyltransferase in human fibroblasts increases the mutagenic response to n-methyl-n'-nitro-n-nitrosoguanidine Carcinogenesis. 6: 1823-1826. PMID 4064256 DOI: 10.1093/Carcin/6.12.1823  0.382
1985 Dolan ME, Corsico CD, Pegg AE. Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochemical and Biophysical Research Communications. 132: 178-85. PMID 4062928 DOI: 10.1016/0006-291X(85)91004-6  0.36
1985 Pegg AE, Erwin BG. Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines Biochemical Journal. 231: 285-289. PMID 4062898 DOI: 10.1042/Bj2310285  0.332
1985 Dolan ME, Pegg AE. Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver o6-alkylguanine-DNA-alkyltransferase Carcinogenesis. 6: 1611-1614. PMID 4053281 DOI: 10.1093/Carcin/6.11.1611  0.352
1985 Pegg AE, Erwin BG, Persson L. Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone). Biochimica Et Biophysica Acta. 842: 111-8. PMID 4052449 DOI: 10.1016/0304-4165(85)90192-8  0.364
1985 Seely JE, Persson L, Sertich GJ, Pegg AE. Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney. The Biochemical Journal. 226: 577-86. PMID 3994674 DOI: 10.1042/Bj2260577  0.329
1985 Shirahata A, Christman KL, Pegg AE. Quantitation of S-adenosylmethionine decarboxylase protein Biochemistry. 24: 4417-4423. PMID 3902085 DOI: 10.1021/Bi00337A024  0.353
1985 Morimoto K, Dolan ME, Scicchitano D, Pegg AE. Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli. Carcinogenesis. 6: 1027-31. PMID 3893782 DOI: 10.1093/Carcin/6.7.1027  0.363
1984 Pegg AE. Methylation of the o6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents Cancer Investigation. 2: 223-231. PMID 6733565 DOI: 10.3109/07357908409104376  0.319
1984 Wiestler O, Kleihues P, Pegg AE. O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis. 5: 121-4. PMID 6690082 DOI: 10.1093/Carcin/5.1.121  0.315
1984 Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ. Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase. European Journal of Cancer & Clinical Oncology. 20: 417-20. PMID 6538500 DOI: 10.1016/0277-5379(84)90090-7  0.347
1984 Domoradzki J, Pegg AE, Dolan ME, Maher VM, Mccormick JJ. Correlation between o-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-n'-nitro-N-nitrosoguanidine Carcinogenesis. 5: 1641-1647. PMID 6499116 DOI: 10.1093/Carcin/5.12.1641  0.369
1984 Erwin BG, Persson L, Pegg AE. Differential inhibition of histone and polyamine acetylases by multisubstrate analogues. Biochemistry. 23: 4250-5. PMID 6487599 DOI: 10.1021/Bi00313A036  0.348
1984 Persson L, Seely JE, Pegg AE. Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney Biochemistry. 23: 3777-3783. PMID 6477895 DOI: 10.1021/Bi00311A033  0.373
1984 Ewton DZ, Erwin BG, Pegg AE, Florini JR. The role of polyamines in somatomedin-stimulated differentiation of L6 myoblasts. Journal of Cellular Physiology. 120: 263-70. PMID 6430921 DOI: 10.1002/Jcp.1041200302  0.325
1984 Oredsson SM, Pegg AE, Alhonen-Hongisto L, Deen DF, Marton LJ. Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells. European Journal of Cancer & Clinical Oncology. 20: 535-42. PMID 6426969 DOI: 10.1016/0277-5379(84)90240-2  0.422
1984 Zagon IS, McLaughlin PJ, Seely JE, Hoeksema GW, Pegg AE. Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled alpha-difluoromethylornithine. Cell and Tissue Research. 235: 371-7. PMID 6423285 DOI: 10.1007/Bf00217862  0.358
1984 Erwin BG, Bethell DR, Pegg AE. Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes The American Journal of Physiology. 246. PMID 6422770 DOI: 10.1152/Ajpcell.1984.246.3.C293  0.347
1984 Dolan ME, Scicchitano D, Singer B, Pegg AE. Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli. Biochemical and Biophysical Research Communications. 123: 324-30. PMID 6383380 DOI: 10.1016/0006-291X(84)90416-9  0.355
1984 Pegg AE, Lijinsky W. Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines Chemico-Biological Interactions. 51: 365-370. DOI: 10.1016/0009-2797(84)90161-3  0.335
1983 Matsui I, Pösö H, Pegg AE. Conversion of exogenous spermidine into putrescine after administration to rats. Biochimica Et Biophysica Acta. 719: 199-207. PMID 7150638 DOI: 10.1016/0304-4165(82)90089-7  0.324
1983 Pegg AE. Repair of alkylated DNA by cell extracts from various organs and species Basic Life Sciences. 24: 545-563. PMID 6860275 DOI: 10.1007/978-1-4684-4400-1_29  0.381
1983 Montesano R, Bresil H, Planche-Martel G, Pegg AE, Margison G. Modification of DNA repair processes induced by nitrosamines. Basic Life Sciences. 24: 531-43. PMID 6860274 DOI: 10.1007/978-1-4684-4400-1_28  0.38
1983 Seely JE, Pegg AE. Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver Biochemical Journal. 216: 701-707. PMID 6667263 DOI: 10.1042/Bj2160701  0.352
1983 Della Ragione F, Erwin BG, Pegg AE. Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N1-acetyltransferase. The Biochemical Journal. 213: 707-12. PMID 6615455 DOI: 10.1042/Bj2130707  0.352
1983 Della Ragione F, Pegg AE. Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase Biochemical Journal. 213: 701-706. PMID 6615454 DOI: 10.1042/Bj2130701  0.322
1983 Pösö H, Pegg AE. Measurement of the amount of ornithine decarboxylase in Saccharomyces cerevisiae and Saccharomyces uvarum by using α-[5-14C]difluoromethylornithine Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 747: 209-214. PMID 6412757 DOI: 10.1016/0167-4838(83)90099-7  0.347
1983 Erwin BG, Ewton DZ, Florini JR, Pegg AE. Polyamine depletion inhibits the differentiation of L6 myoblast cells. Biochemical and Biophysical Research Communications. 114: 944-9. PMID 6412710 DOI: 10.1016/0006-291X(83)90651-4  0.307
1983 Della Ragione F, Pegg AE. Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocystein hydrolase by 5'-isobutylthioadenosine Biochemical Journal. 210: 429-435. PMID 6407475 DOI: 10.1042/Bj2100429  0.37
1983 Pegg AE, Bitonti AJ, McCann PP, Coward JK. Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine. Febs Letters. 155: 192-6. PMID 6406265 DOI: 10.1016/0014-5793(82)80600-5  0.36
1983 Pegg AE, Jacobs G. Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species Biochemical Journal. 213: 495-502. PMID 6351843 DOI: 10.1042/Bj2130495  0.352
1983 Erwin BG, Seely JE, Pegg AE. Mechanism of stimulation of ornithine decarboxylase activity in transformed mouse fibroblasts. Biochemistry. 22: 3027-32. PMID 6307351 DOI: 10.1021/Bi00281A037  0.361
1983 Matsui I, Otani S, Kuramoto A, Morisawa S, Pegg AE. Induction of spermidine N1-acetyltransferase by sodium n-butyrate and phytohemagglutinin in bovine lymphocytes. Journal of Biochemistry. 93: 961-6. PMID 6305929 DOI: 10.1093/Oxfordjournals.Jbchem.A134251  0.358
1983 Bacchi CJ, Garofalo J, Mockenhaupt D, McCann PP, Diekema KA, Pegg AE, Nathan HC, Mullaney EA, Chunosoff L, Sjoerdsma A, Hutner SH. In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei Molecular and Biochemical Parasitology. 7: 209-225. PMID 6193423 DOI: 10.1016/0166-6851(83)90022-1  0.321
1982 Scicchitano D, Pegg AE. Kinetics of repair of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase in, vitro and in, vivo Biochemical and Biophysical Research Communications. 109: 995-1001. PMID 7187611 DOI: 10.1016/0006-291X(82)92038-1  0.394
1982 Della Ragione F, Pegg AE. Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver Biochemistry. 21: 6152-6158. PMID 7150547 DOI: 10.1021/Bi00267A020  0.34
1982 Pösö H, Pegg AE. Effect of carbon tetrachloride on polyamine metabolism in rodent liver Archives of Biochemistry and Biophysics. 217: 730-737. PMID 7138035 DOI: 10.1016/0003-9861(82)90554-9  0.305
1982 Pösö H, Pegg AE. Comparison of S-adenosylmethionine decarboxylases from rat liver and muscle Biochemistry. 21: 3116-3122. PMID 7104315 DOI: 10.1021/Bi00256A013  0.321
1982 Matsui I, Kamei M, Otani S, Morisawa S, Pegg AE. Occurrence and induction of spermidine-N1-acetyltransferase in Escherichia coli. Biochemical and Biophysical Research Communications. 106: 1155-60. PMID 7052085 DOI: 10.1016/0006-291X(82)91233-5  0.356
1982 Swenberg JA, Bedell MA, Billings KC, Umbenhauer DR, Pegg AE. Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen. Proceedings of the National Academy of Sciences of the United States of America. 79: 5499-502. PMID 6957878 DOI: 10.1073/Pnas.79.18.5499  0.384
1982 Pegg AE, Roberfroid M, von Bahr C, Foote RS, Mitra S, Bresil H, Likhachev A, Montesano R. Removal of O6-methylguanine from DNA by human liver fractions. Proceedings of the National Academy of Sciences of the United States of America. 79: 5162-5. PMID 6957855 DOI: 10.1073/Pnas.79.17.5162  0.377
1982 Seely JE, Poso H, Pegg AE. Measurement of the number of ornithine decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled α-difluoromethylornithine Biochemical Journal. 206: 311-318. PMID 6816220 DOI: 10.1042/Bj2060311  0.358
1982 Pegg AE, McCann PP. Polyamine metabolism and function The American Journal of Physiology. 243. PMID 6814260 DOI: 10.1152/Ajpcell.1982.243.5.C212  0.329
1982 Seely JE, Pösö H, Pegg AE. Purification of ornithine decarboxylase from kidneys of androgen-treated mice Biochemistry. 21: 3394-3399. PMID 6810923 DOI: 10.1021/Bi00257A023  0.349
1982 Pegg AE, Pösö H, Shuttleworth K, Bennett RA. Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine. The Biochemical Journal. 202: 519-26. PMID 6807294 DOI: 10.1042/Bj2020519  0.363
1982 Pegg AE, Seely J, Zagon IS. Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine. Science (New York, N.Y.). 217: 68-70. PMID 6806900 DOI: 10.1126/Science.6806900  0.361
1982 Stoscheck CM, Erwin BG, Florini JR, Richman RA, Pegg AE. Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation. Journal of Cellular Physiology. 110: 161-8. PMID 6802862 DOI: 10.1002/Jcp.1041100209  0.364
1982 Pösö H, Pegg AE. Effect of α-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver. Reversal of inhibition of DNA synthesis by putrescine Bba - Gene Structure and Expression. 696: 179-186. PMID 6800405 DOI: 10.1016/0167-4781(82)90026-4  0.342
1982 Pegg AE, Shuttleworth K, Hibasami H. Specificity of mammalian spermidine synthase and spermine synthase. The Biochemical Journal. 197: 315-20. PMID 6798961 DOI: 10.1042/Bj1970315  0.318
1982 Pegg AE, Tang KC, Coward JK. Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. Biochemistry. 21: 5082-9. PMID 6291600 DOI: 10.1021/Bi00263A036  0.363
1982 Bethell DR, Hibasami H, Pegg AE. Regulation of polyamine content in cultured fibroblasts The American Journal of Physiology. 243. PMID 6291400 DOI: 10.1152/Ajpcell.1982.243.5.C262  0.363
1981 Umbenhauer DR, Pegg AE. Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes Chemico-Biological Interactions. 33: 229-238. PMID 7460067 DOI: 10.1016/0009-2797(81)90043-0  0.376
1981 Poso H, Pegg AE. Differences between tissues in response of S-adenosylmethionine decarboxylase to administration of polyamines Biochemical Journal. 200: 629-637. PMID 7342972 DOI: 10.1042/Bj2000629  0.342
1981 Pegg AE, Perry W. Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins Carcinogenesis. 2: 1195-1200. PMID 7318156 DOI: 10.1093/Carcin/2.11.1195  0.369
1981 Pegg AE, Perry W, Bennett RA. Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts Biochemical Journal. 197: 195-201. PMID 7317030 DOI: 10.1042/Bj1970195  0.422
1981 Pegg AE, Borchardt RT, Coward JK. Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts. The Biochemical Journal. 194: 79-89. PMID 7305994 DOI: 10.1042/Bj1940079  0.344
1981 Margison GP, Pegg AE. Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts Proceedings of the National Academy of Sciences of the United States of America. 78: 861-865. PMID 7015334 DOI: 10.1073/Pnas.78.2.861  0.365
1981 Pegg AE, Hibasami H, Matsui I, Bethell DR. Formation and interconversion of putrescine and spermidine in mammalian cells Advances in Enzyme Regulation. 19: 427-451. PMID 6801933 DOI: 10.1016/0065-2571(81)90027-3  0.394
1981 Pritchard ML, Seely JE, Pösö H, Jefferson LS, Pegg AE. Binding of radioactive alpha-difluoromethylornithine to rat liver ornithine decarboxylase. Biochemical and Biophysical Research Communications. 100: 1597-603. PMID 6794570 DOI: 10.1016/0006-291X(81)90701-4  0.333
1981 Bethell DR, Pegg AE. Uptake of putrescine by 3T3 and SV3T3 cells and its effect on ornithine decarboxylase activity Journal of Cellular Physiology. 109: 461-468. PMID 6274881 DOI: 10.1002/Jcp.1041090312  0.324
1981 Isao Matsui, Pegg AE. Effect of inhibitors of protein synthesis on rat liver spermidine N1-acetyltransferase Bba - General Subjects. 675: 373-378. PMID 6168299 DOI: 10.1016/0304-4165(81)90028-3  0.341
1981 Montesano R, Pegg AE, Margison GP. Alkylation of DNA and carcinogenicity of N-nitroso compounds. Journal of Toxicology and Environmental Health. 6: 1001-8. PMID 6162032 DOI: 10.1080/15287398009529922  0.375
1980 Matsui I, Pegg AE. Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol Biochimica Et Biophysica Acta. 633: 87-94. PMID 7448208 DOI: 10.1016/0304-4165(80)90040-9  0.31
1980 Tang KC, Pegg AE, Coward JK. Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane. Biochemical and Biophysical Research Communications. 96: 1371-7. PMID 7437076 DOI: 10.1016/0006-291X(80)90102-3  0.308
1980 Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE. Studies of inhibition of rat spermidine synthase and spermine synthase. The Biochemical Journal. 187: 419-28. PMID 7396856 DOI: 10.1042/Bj1870419  0.328
1980 McCann PP, Tardif C, Pegg AE, Diekema K. The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells. Life Sciences. 26: 2003-10. PMID 7190634 DOI: 10.1016/0024-3205(80)90633-5  0.335
1980 Pegg AE, Hibasami H. Polyamine metabolism during cardiac hypertrophy The American Journal of Physiology. 239. PMID 6449152 DOI: 10.1152/Ajpendo.1980.239.5.E372  0.365
1980 Klingensmith MR, Freifeld AG, Pegg AE, Jefferson LS. Effects of growth hormone and glucagon on ornithine decarboxylase activity and adenosine 3',5'-monophosphate levels in isolated rat hepatocytes. Endocrinology. 106: 125-32. PMID 6243092 DOI: 10.1210/Endo-106-1-125  0.328
1979 Pegg AE, Swann PF. Metabolism of O6-alkyldeoxyguanosines and their effect on removal of O6-methylguanine from rat liver DNA Bba Section Nucleic Acids and Protein Synthesis. 565: 241-252. PMID 518880 DOI: 10.1016/0005-2787(79)90202-8  0.34
1979 Pegg AE, McGill S. Decarboxylation of ornithine and lysine in rat tissues Bba - Enzymology. 568: 416-427. PMID 486492 DOI: 10.1016/0005-2744(79)90310-3  0.314
1979 Wilson J, Corti A, Hawkins M, Williams-Ashman HG, Pegg AE. The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver Biochemical Journal. 180: 515-522. PMID 486130 DOI: 10.1042/Bj1800515  0.312
1979 Isom HC, Pegg AE. Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by α-difluoromethylornithine Bba Section Nucleic Acids and Protein Synthesis. 564: 402-413. PMID 227464 DOI: 10.1016/0005-2787(79)90031-5  0.328
1978 Pegg AE. Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts Biochemical and Biophysical Research Communications. 84: 166-173. PMID 728125 DOI: 10.1016/0006-291X(78)90278-4  0.377
1978 Pegg AE, Hui G, Rogers KJ. Effect of hypophysectomy on persistence of methylated purines in rat liver deoxyribonucleic acid after administration of dimethylnitrosamine Bba Section Nucleic Acids and Protein Synthesis. 520: 671-678. PMID 718921 DOI: 10.1016/0005-2787(78)90152-1  0.334
1978 Pegg AE, Hui G. Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine Biochemical Journal. 173: 739-748. PMID 708371 DOI: 10.1042/Bj1730739  0.338
1978 Pegg AE. Effect of pretreatment with other dialkylnitrosamines on excision from hepatic DNA of O6-methylguanine produced by dimethylnitrosamine Chemico-Biological Interactions. 22: 109-116. PMID 688522 DOI: 10.1016/0009-2797(78)90154-0  0.376
1978 Hibasami H, Pegg AE. Differential inhibition of mammalian aminopropyltransferase activities Biochemical and Biophysical Research Communications. 81: 1398-1405. PMID 666825 DOI: 10.1016/0006-291X(78)91291-3  0.343
1978 Pegg AE. Dimethylnitrosamine inhibits enzymatic removal of O6- methylguanine from DNA [30] Nature. 274: 182-184. PMID 662015 DOI: 10.1038/274182A0  0.382
1978 Pegg AE, Conover C, Wrona A. Effects of aliphatic diamines on rat liver ornithine decarboxylase activity Biochemical Journal. 170: 651-660. PMID 646807 DOI: 10.1042/Bj1700651  0.31
1978 Wiegand L, Pegg AE. Effects of inhibitors of S-adenosylmethionine decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy Bba Section Nucleic Acids and Protein Synthesis. 517: 169-180. PMID 623755 DOI: 10.1016/0005-2787(78)90044-8  0.357
1978 Pegg AE, McGill SM. Inhibition of diamine oxidase by 1,1-[(methylethanediylidene)-dinitrilo]-bis-(3-aminoguanidine) and 1,1'-[(methylethanediylidene)-dinitrilo]-diguanidine Biochemical Pharmacology. 27: 1625-1629. PMID 100119 DOI: 10.1016/0006-2952(78)90170-3  0.331
1977 Pegg AE. Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity Biochemical Journal. 166: 81-88. PMID 901421 DOI: 10.1042/Bj1660081  0.303
1977 Jefferson LS, Pegg AE. Studies on ornithine decarboxylase activity in the isolated perfused rat liver Bba - Enzymology. 484: 177-187. PMID 889842 DOI: 10.1016/0005-2744(77)90123-1  0.329
1977 Feil PD, Pegg AE, Demers LM, Bardin CW. Involvement of polyamines in the progestin-induced stimulation of endometrial glycogen synthesis during organ culture. Biochemical and Biophysical Research Communications. 75: 1-6. PMID 849297 DOI: 10.1016/0006-291X(77)91280-3  0.308
1977 Pegg AE. Alkylation of rat liver dna by dimethylnitrosamine: Effect of dosage on o6-methyiguanine levels Journal of the National Cancer Institute. 58: 681-687. PMID 839563 DOI: 10.1093/Jnci/58.3.681  0.344
1976 Pegg AE, Conover C. Irreversible inhibition of mammalian and yeast S-adenosylmethionine decarboxylase by 1,1′-(methylethanediylidenedinitrilo)-bis(3-aminoguanidine) Biochemical and Biophysical Research Communications. 69: 766-774. PMID 773381 DOI: 10.1016/0006-291X(76)90941-4  0.324
1975 Kleihues P, Hossmann KA, Pegg AE, Kobayashi K, Zimmermann V. Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery. Brain Research. 95: 61-73. PMID 1156869 DOI: 10.1016/0006-8993(75)90207-3  0.309
1975 Wilkinson R, Hawks A, Pegg AE. Methylation of rat liver mitochondrial deoxyribonucleic acid by chemical carcinogens and associated alterations in physical properties Chemico-Biological Interactions. 10: 157-167. PMID 165008 DOI: 10.1016/0009-2797(75)90109-X  0.325
1974 Pegg AE. Sites of methylation of purified transfer ribonucleic acid preparations by enzymes from normal tissues and from tumours induced by dimethylnitrosamine and 1,2 dimethylhydrazine Biochemical Journal. 137: 239-248. PMID 4596141 DOI: 10.1042/Bj1370239  0.313
1974 Pegg AE, Hawks AM. Further investigation of the increased transfer ribonucleic acid methylase activity in tumours of the mouse colon Biochemical Journal. 137: 229-238. PMID 4596140 DOI: 10.1042/Bj1370229  0.329
1974 Pegg AE. Purification of rat liver S adenosyl L methionine decarboxylase Biochemical Journal. 141: 581-583. PMID 4455223 DOI: 10.1042/Bj1410581  0.326
1973 Kay JE, Pegg AE. Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation. Febs Letters. 29: 301-304. PMID 11946938 DOI: 10.1016/0014-5793(73)80044-4  0.305
1973 Pegg AE. Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone) Biochemical Journal. 132: 537-540. PMID 4724588 DOI: 10.1042/Bj1320537  0.323
1973 Pegg AE, Corti A, Williams-Ashman HG. Paradoxical enhancement of S-adenosylmethionine decarboxylase in rat tissues following administration of the specific inhibitor methyl glyoxal bis(guanylhydrazone). Biochemical and Biophysical Research Communications. 52: 696-701. PMID 4711181 DOI: 10.1016/0006-291X(73)90768-7  0.361
1972 Swann PF, Pegg AE, Hawks A, Farber E, Magee PN. Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. The Biochemical Journal. 123: 175-81. PMID 5127333 DOI: 10.1042/Bj1230175  0.32
1972 Pegg AE. Studies of the ethylation of rat liver transfer ribonucleic acid after administration of L-ethionine Biochemical Journal. 128: 59-68. PMID 5085644 DOI: 10.1042/Bj1280059  0.311
1972 Stewart BW, Pegg AE. Changes in tRNA methylase activity of rat kidney following administration of the carcinogen, dimethylnitrosamine Bba Section Nucleic Acids and Protein Synthesis. 281: 416-424. PMID 4565241 DOI: 10.1016/0005-2787(72)90457-1  0.326
1972 Hoffbrand AV, Pegg AE. Base composition of normal and megaloblastic bone marrow DNA Nature: New Biology. 235: 187-188. PMID 4501205 DOI: 10.1038/Newbio235187A0  0.318
1971 Pegg AE. The effects of diamines and polyamines on enzymic methylation of nucleic acid Bba Section Nucleic Acids and Protein Synthesis. 232: 630-642. PMID 4933881 DOI: 10.1016/0005-2787(71)90755-6  0.334
1970 Pegg AE, Lockwood DH, Williams-Ashman HG. Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth. The Biochemical Journal. 117: 17-31. PMID 5420953 DOI: 10.1042/Bj1170017  0.304
1970 Pegg AE, Williams-Ashman HG. Enzymic synthesis of spermine in rat prostate Archives of Biochemistry and Biophysics. 137: 156-165. PMID 4985091 DOI: 10.1016/0003-9861(70)90422-4  0.332
1969 Pegg AE, Williams-Ashman HG. Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate Biochemical Journal. 115: 241-247. PMID 5378381 DOI: 10.1042/Bj1150241  0.3
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