| Year |
Citation |
Score |
| 2024 |
Li Y, Tang MK, Carmella SG, Peters CP, Cohen JD, Hegeman AD, Hecht SS. Hydroponic Growth of [C]-Labeled Tobacco for DNA Damage Studies in Cigarette Smokers. Journal of Agricultural and Food Chemistry. PMID 38953685 DOI: 10.1021/acs.jafc.4c00528 |
0.312 |
|
| 2024 |
Peterson LA, Stanfill SB, Hecht SS. An Update on the Formation in Tobacco, Toxicity, and Carcinogenicity of N'-Nitrosonornicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. PMID 38437625 DOI: 10.1093/carcin/bgae018 |
0.323 |
|
| 2023 |
Stanfill SB, Hecht SS, Joerger AC, González PJ, Maia LB, Rivas MG, Moura JJG, Gupta AK, Le Brun NE, Crack JC, Hainaut P, Sparacino-Watkins C, Tyx RE, Pillai SD, Zaatari GS, et al. From cultivation to cancer: formation of -nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications. Critical Reviews in Toxicology. 1-44. PMID 38050998 DOI: 10.1080/10408444.2023.2264327 |
0.313 |
|
| 2023 |
Cheng G, Guo J, Wang R, Yuan JM, Balbo S, Hecht SS. Quantitation by Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry of Multiple DNA Adducts Related to Cigarette Smoking in Oral Cells in the Shanghai Cohort Study. Chemical Research in Toxicology. PMID 36719849 DOI: 10.1021/acs.chemrestox.2c00393 |
0.33 |
|
| 2022 |
Hecht SS, Gupta PC, Sturla SJ, Wang Y. 50 Years of Research on Tobacco-Specific Nitrosamines: A Virtual Collection of Emerging Knowledge of Chemical Toxicology of Tobacco and Nicotine Delivery Systems and Call for Contributions to a Landmark Special Issue. Chemical Research in Toxicology. PMID 35635503 DOI: 10.1021/acs.chemrestox.2c00144 |
0.506 |
|
| 2022 |
Li Y, Hecht SS. Metabolism and DNA Adduct Formation of Tobacco-Specific -Nitrosamines. International Journal of Molecular Sciences. 23. PMID 35563500 DOI: 10.3390/ijms23095109 |
0.319 |
|
| 2022 |
Hecht SS, Hatsukami DK. Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention. Nature Reviews. Cancer. PMID 34980891 DOI: 10.1038/s41568-021-00423-4 |
0.315 |
|
| 2021 |
Li Y, Hecht SS. Identification of an -Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA. Chemical Research in Toxicology. PMID 33705110 DOI: 10.1021/acs.chemrestox.1c00013 |
0.329 |
|
| 2021 |
Peterson LA, Oram MK, Flavin M, Seabloom D, Smith WE, O'Sullivan MG, Vevang KR, Upadhyaya P, Stornetta A, Floeder AC, Ho YY, Zhang L, Hecht SS, Balbo S, Wiedmann TS. Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung. Chemical Research in Toxicology. PMID 33629582 DOI: 10.1021/acs.chemrestox.0c00350 |
0.318 |
|
| 2020 |
Luo K, Luo X, Cao W, Hochalter JB, Paiano V, Sipe CJ, Carmella SG, Murphy SE, Jensen J, Lam S, Golin AP, Bergstrom L, Midthun D, Fujioka N, Hatsukami D, ... Hecht SS, et al. Cigarette Smoking Enhances the Metabolic Activation of the Polycyclic Aromatic Hydrocarbon Phenanthrene in Humans. Carcinogenesis. PMID 33319219 DOI: 10.1093/carcin/bgaa137 |
0.318 |
|
| 2020 |
Travers MJ, Rivard C, Sharma E, Retzky S, Yucesoy B, Goniewicz ML, Stanton CA, Chen J, Callahan-Lyon P, Kimmel HL, Xia B, Wang Y, Sosnoff CS, De Jesús VR, Blount BC, ... Hecht SS, et al. Biomarkers of Exposure among USA Adult Hookah Users: Results from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (2013-2014). International Journal of Environmental Research and Public Health. 17. PMID 32887496 DOI: 10.3390/Ijerph17176403 |
0.337 |
|
| 2020 |
Guo J, Chen H, Upadhyaya P, Zhao Y, Turesky RJ, Hecht SS. Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissue DNA of rats exposed to tobacco-specific nitrosamines and in lung and leukocyte DNA of cigarette smokers and non-smokers. Chemical Research in Toxicology. PMID 32833447 DOI: 10.1021/Acs.Chemrestox.0C00265 |
0.401 |
|
| 2020 |
Luo K, Carmella SG, Zhao Y, Tang MK, Hecht SS. Identification and quantification of phenanthrene ortho-quinones in human urine and their association with lipid peroxidation. Environmental Pollution (Barking, Essex : 1987). 266: 115342. PMID 32805605 DOI: 10.1016/J.Envpol.2020.115342 |
0.325 |
|
| 2020 |
Xia B, Blount BC, Guillot T, Brosius C, Li Y, Van Bemmel DM, Kimmel HL, Chang CM, Borek N, Edwards KC, Lawrence C, Hyland A, Goniewicz ML, Pine BN, Xia Y, ... ... Hecht SS, et al. Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014). Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 32716026 DOI: 10.1093/Ntr/Ntaa110 |
0.389 |
|
| 2020 |
Paiano V, Maertens L, Guidolin V, Yang J, Balbo S, Hecht SS. Quantitative Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers. Chemical Research in Toxicology. PMID 32635726 DOI: 10.1021/Acs.Chemrestox.0C00223 |
0.378 |
|
| 2020 |
Hu Q, Corral P, Narayanapillai SC, Leitzman P, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C. Oral dosing of dihydromethysticin ahead of tobacco carcinogen NNK effectively prevents lung tumorigenesis in A/J mice. Chemical Research in Toxicology. PMID 32476407 DOI: 10.1021/Acs.Chemrestox.0C00161 |
0.336 |
|
| 2020 |
Cheng G, Reisinger SA, Shields PG, Hatsukami DK, Balbo S, Hecht SS. Quantitation by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry of DNA adducts derived from methyl glyoxal and carboxyethylating agents in leukocytes of smokers and non-smokers. Chemico-Biological Interactions. 109140. PMID 32442416 DOI: 10.1016/J.Cbi.2020.109140 |
0.402 |
|
| 2020 |
Luo X, Carmella SG, Chen M, Jensen JA, Wilkens LR, Le Marchand L, Hatsukami DK, Murphy SE, Hecht SS. Urinary cyanoethyl mercapturic acid, a biomarker of the smoke toxicant acrylonitrile, clearly distinguishes smokers from non-smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 32391548 DOI: 10.1093/Ntr/Ntaa080 |
0.4 |
|
| 2020 |
Luo K, Hochalter JB, Carmella SG, Hecht SS. Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1141: 122023. PMID 32109746 DOI: 10.1016/J.Jchromb.2020.122023 |
0.404 |
|
| 2020 |
Wang Y, Chanickal Narayanapillai S, Tessier KM, Strayer LG, Upadhyaya P, Hu Q, Kingston R, Salloum RG, Lu J, Hecht SS, Hatsukami DK, Fujioka N, Xing C. The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 32102948 DOI: 10.1158/1940-6207.Capr-19-0501 |
0.436 |
|
| 2020 |
Peterson LA, Balbo S, Fujioka N, Hatsukami DK, Hecht SS, Murphy SE, Stepanov I, Tretyakova N, Turesky RJ, Villalta PW. Applying tobacco, environmental and dietary-related biomarkers to understand cancer etiology and evaluate prevention strategies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 32051197 DOI: 10.1158/1055-9965.Epi-19-1356 |
0.385 |
|
| 2020 |
Cheng YC, Reyes-Guzman CM, Christensen CH, Rostron BL, Edwards KC, Wang L, Feng J, Jarrett JM, Ward CD, Xia B, Kimmel HL, Conway K, Leggett C, Taylor K, Lawrence C, ... ... Hecht SS, et al. Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013-14). Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 31988072 DOI: 10.1158/1055-9965.Epi-19-0766 |
0.303 |
|
| 2020 |
Chen M, Carmella SG, Li Y, Zhao Y, Hecht SS. Resolution and quantitation of mercapturic acids derived from crotonaldehyde, methacrolein, and methyl vinyl ketone in the urine of smokers and non-smokers. Chemical Research in Toxicology. PMID 31957442 DOI: 10.1021/Acs.Chemrestox.9B00491 |
0.355 |
|
| 2019 |
Tidey JW, Colby SM, Denlinger-Apte RL, Goodwin C, Cioe PA, Cassidy RN, Swift RM, Lindgren BR, Rubin N, Murphy SE, Hecht SS, Hatsukami DK, Donny EC. Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 21: S38-S45. PMID 31867650 DOI: 10.1093/Ntr/Ntz133 |
0.35 |
|
| 2019 |
Hatsukami D, Meier E, Lindgren BR, Anderson A, Reisinger S, Norton K, Strayer L, Jensen J, Dick L, Murphy S, Carmella S, Tang MK, Chen M, Hecht SS, O'Connor RJ, et al. A Randomized Clinical Trial Examining the Effects of Instructions for Electronic Cigarette Use on Smoking-Related Behaviors, and Biomarkers of Exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31828315 DOI: 10.1093/Ntr/Ntz233 |
0.372 |
|
| 2019 |
Boldry EJ, Yuan JM, Carmella SG, Wang R, Tessier K, Hatsukami DK, Hecht SS, Tretyakova N. Effects of 2-phenethyl isothiocyanate on metabolism of 1,3-butadiene in smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 31771940 DOI: 10.1158/1940-6207.Capr-19-0296 |
0.382 |
|
| 2019 |
Meier E, Vandrey R, Rubin N, Pacek LR, Jensen JA, Donny EC, Hecht SS, Carmella SG, Murphy SE, Luo X, Stepanov I, Ikuemonisan J, Severson H, al'Absi M, Hatsukami DK. Cigarette Smokers vs. Co-users of Cannabis and Cigarettes: Exposure to Toxicants. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31616939 DOI: 10.1093/Ntr/Ntz199 |
0.351 |
|
| 2019 |
Benowitz NL, Bernert JT, Foulds J, Hecht SS, Jacob P, Jarvis MJ, Joseph A, Oncken C, Piper ME. Biochemical Verification of Tobacco Use and Abstinence: 2019 Update. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31570931 DOI: 10.1093/Ntr/Ntz132 |
0.34 |
|
| 2019 |
Tomar SL, Hecht SS, Jaspers I, Gregory RL, Stepanov I. Oral Health Effects of Combusted and Smokeless Tobacco Products. Advances in Dental Research. 30: 4-10. PMID 31538806 DOI: 10.1177/0022034519872480 |
0.312 |
|
| 2019 |
St Helen G, Benowitz NL, Ko J, Jacob P, Gregorich SE, Pérez-Stable EJ, Murphy SE, Hecht SS, Hatsukami DK, Donny EC. Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers. Journal of Exposure Science & Environmental Epidemiology. PMID 31406274 DOI: 10.1038/S41370-019-0159-9 |
0.384 |
|
| 2019 |
Meier E, Lindgren BR, Anderson A, Reisinger SA, Norton KJ, Jensen J, Strayer L, Dick L, Tang MK, Chen M, Carmella SG, Hecht SS, Murphy SE, Yang J, Stepanov I, et al. A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31321423 DOI: 10.1093/Ntr/Ntz055 |
0.369 |
|
| 2019 |
McElroy JP, Carmella SG, Heskin AK, Tang MK, Murphy SE, Reisinger SA, Jensen JA, Hatsukami DK, Hecht SS, Shields PG. Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage. Plos One. 14: e0218386. PMID 31251764 DOI: 10.1371/Journal.Pone.0218386 |
0.396 |
|
| 2019 |
Hatsukami DK, Luo X, Heskin AK, Tang MK, Carmella SG, Jensen J, Robinson JD, Vandrey R, Drobes DJ, Strasser AA, al'Absi M, Leischow S, Cinciripini PM, Koopmeiners J, Ikuemonisan J, ... ... Hecht SS, et al. Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects. Addiction (Abingdon, England). PMID 31140663 DOI: 10.1111/Add.14695 |
0.398 |
|
| 2019 |
Carmella SG, Heskin AK, Tang MK, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al'Absi M, ... ... Hecht SS, et al. Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation. Plos One. 14: e0215853. PMID 31022220 DOI: 10.1371/Journal.Pone.0215853 |
0.379 |
|
| 2019 |
Ma B, Stepanov I, Hecht SS. Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke. Toxics. 7. PMID 30893918 DOI: 10.3390/Toxics7010016 |
0.43 |
|
| 2019 |
Ma B, Villalta PW, Hochalter JB, Stepanov I, Hecht SS. Methyl DNA Phosphate Adduct Formation in Lung Tumor Tissue and Adjacent Normal Tissue of Lung Cancer Patients. Carcinogenesis. PMID 30873516 DOI: 10.1093/Carcin/Bgz053 |
0.369 |
|
| 2019 |
Li Y, Ma B, Cao Q, Balbo S, Zhao L, Upadhyaya P, Hecht SS. Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N´-Nitrosonornicotine. Chemical Research in Toxicology. PMID 30740971 DOI: 10.1021/Acs.Chemrestox.9B00007 |
0.364 |
|
| 2019 |
Stram DO, Park SL, Haiman CA, Murphy SE, Patel Y, Hecht SS, Le Marchand L. Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update. Journal of the National Cancer Institute. PMID 30698722 DOI: 10.1093/Jnci/Djy206 |
0.339 |
|
| 2019 |
Yang J, Balbo S, Villalta PW, Hecht SS. Analysis of acrolein-derived 1, N-propanodeoxyguanosine adducts in human lung DNA from smokers and non-smokers. Chemical Research in Toxicology. PMID 30644728 DOI: 10.1021/acs.chemrestox.8b00326 |
0.338 |
|
| 2019 |
Chen M, Carmella SG, Sipe C, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al'Absi M, ... ... Hecht SS, et al. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein. Plos One. 14: e0210104. PMID 30608961 DOI: 10.1371/Journal.Pone.0210104 |
0.392 |
|
| 2019 |
Carroll DM, Allenzara A, Jensen J, Stepanov I, Hecht S, Murphy S, Luo X, Donny E, Hatsukami DK. Biomarkers of Exposure and Potential Harm among Natural American Spirit Smokers Tobacco Regulatory Science. 5: 339-351. DOI: 10.18001/Trs.5.4.4 |
0.319 |
|
| 2018 |
Wang Y, Wong LY, Meng L, Pittman EN, Trinidad DA, Hubbard KL, Etheredge A, Del Valle-Pinero AY, Zamoiski R, van Bemmel DM, Borek N, Patel V, Kimmel HL, Conway KP, Lawrence C, ... ... Hecht SS, et al. Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014). Environment International. 123: 201-208. PMID 30530162 DOI: 10.1016/J.Envint.2018.11.068 |
0.355 |
|
| 2018 |
Hatsukami DK, Luo X, Jensen JA, al'Absi M, Allen SS, Carmella SG, Chen M, Cinciripini PM, Denlinger-Apte R, Drobes DJ, Koopmeiners JS, Lane T, Le CT, Leischow S, Luo K, ... ... Hecht SS, et al. Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. Jama. 320: 880-891. PMID 30193275 DOI: 10.1001/Jama.2018.11473 |
0.359 |
|
| 2018 |
Yuan JM, Carmella SG, Wang R, Tan YT, Adams-Haduch J, Gao YT, Hecht SS. Relationship of the Oxidative Damage Biomarker 8-epi-prostaglandin F2α to Risk of Lung Cancer Development in the Shanghai Cohort Study. Carcinogenesis. PMID 29726912 DOI: 10.1093/Carcin/Bgy060 |
0.401 |
|
| 2018 |
Carlson ES, Upadhyaya P, Villalta PW, Ma B, Hecht SS. Analysis and Identification of 2'-Deoxyadenosine-derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. PMID 29651838 DOI: 10.1021/Acs.Chemrestox.8B00056 |
0.428 |
|
| 2018 |
Kovi RC, Johnson CS, Balbo S, Hecht SS, O'Sullivan MG. Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products. Toxicologic Pathology. 192623317751573. PMID 29390940 DOI: 10.1177/0192623317751573 |
0.366 |
|
| 2018 |
Ma B, Zarth AT, Carlson E, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS. Pyridyloxobutyl, pyridylhydroxybutyl and methyl DNA phosphate adduct formation in rats due to metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Drug Metabolism and Pharmacokinetics. 33: S17-S18. DOI: 10.1016/J.Dmpk.2017.11.080 |
0.34 |
|
| 2017 |
Upadhyaya P, Zarth AT, Fujioka N, Fritz VA, Hecht SS. Identification and analysis of a mercapturic acid conjugate of indole-3-methyl isothiocyanate in the urine of humans who consumed cruciferous vegetables. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1072: 341-346. PMID 29223047 DOI: 10.1016/J.Jchromb.2017.12.001 |
0.315 |
|
| 2017 |
Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS. Identification of More Than One Hundred Structurally Unique DNA-Phosphate Adducts Formed During Rat Lung Carcinogenesis by the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. PMID 29194532 DOI: 10.1093/Carcin/Bgx135 |
0.416 |
|
| 2017 |
Ma B, Zarth AT, Carlson ES, Villalta PW, Stepanov I, Hecht SS. Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Mutagenesis. PMID 29186507 DOI: 10.1093/Mutage/Gex031 |
0.404 |
|
| 2017 |
Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS. Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. PMID 29131934 DOI: 10.1021/Acs.Chemrestox.7B00281 |
0.393 |
|
| 2017 |
Villalta PW, Hochalter JB, Hecht SS. Ultra-sensitive High Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung. Analytical Chemistry. PMID 29111668 DOI: 10.1021/Acs.Analchem.7B02856 |
0.375 |
|
| 2017 |
Carlson ES, Upadhyaya P, Hecht SS. A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s. Journal of Visualized Experiments : Jove. PMID 28994777 DOI: 10.3791/56312 |
0.359 |
|
| 2017 |
Puppala M, Narayanapillai SC, Leitzman P, Sun H, Upadhyaya P, O'Sullivan MG, Hecht SS, Xing C. Pilot in vivo structure-activity relationship of dihydromethys-ticin in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced O6-methylguanine and lung tumor in A/J mice. Journal of Medicinal Chemistry. PMID 28806079 DOI: 10.1021/Acs.Jmedchem.7B00921 |
0.305 |
|
| 2017 |
Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS. Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon. Chemico-Biological Interactions. PMID 28693886 DOI: 10.1016/J.Cbi.2017.07.005 |
0.404 |
|
| 2017 |
Khariwala SS, Ma B, Ruszczak C, Carmella SG, Lindgren BR, Hatsukami DK, Hecht SS, Stepanov I. High level of tobacco carcinogen-derived DNA damage in oral cells is an independent predictor of oral/head and neck cancer risk in smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 28679497 DOI: 10.1158/1940-6207.Capr-17-0140 |
0.435 |
|
| 2017 |
Kassem NOF, Kassem NO, Liles S, Zarth AT, Jackson SR, Daffa RM, Chatfield DA, Carmella SG, Hecht SS, Hovell MF. Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco Secondhand Smoke: Implications for regulating hookah tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28591850 DOI: 10.1093/Ntr/Ntx133 |
0.398 |
|
| 2017 |
Park SL, Murphy SE, Wilkens LR, Stram DO, Hecht SS, Le Marchand L. Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. Plos One. 12: e0178435. PMID 28542511 DOI: 10.1371/Journal.Pone.0178435 |
0.426 |
|
| 2017 |
Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, et al. Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00343.2016. PMID 28522563 DOI: 10.1152/Ajplung.00343.2016 |
0.344 |
|
| 2017 |
Yuan JM, Nelson HH, Carmella SG, Wang R, Kuriger-Laber J, Jin A, Adams-Haduch J, Hecht SS, Koh WP, Murphy SE. CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study. Carcinogenesis. PMID 28182203 DOI: 10.1093/Carcin/Bgx012 |
0.421 |
|
| 2017 |
Yang J, Carmella SG, Hecht SS. Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1044: 127-131. PMID 28107699 DOI: 10.1016/J.Jchromb.2017.01.008 |
0.367 |
|
| 2017 |
Hecht SS. Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers. Chemical Research in Toxicology. 30: 367-375. PMID 28092948 DOI: 10.1021/Acs.Chemrestox.6B00372 |
0.429 |
|
| 2017 |
Peterson LA, Hecht SS. Tobacco, e-cigarettes, and child health. Current Opinion in Pediatrics. PMID 28059903 DOI: 10.1097/Mop.0000000000000456 |
0.317 |
|
| 2017 |
Hecht S, Park SL, Carmella S, Stram D, Haiman C, Le Marchand L, Murphy S, Yuan J. ED01.02 Tobacco Carcinogens and Lung Cancer Susceptibility Journal of Thoracic Oncology. 12: S19-S20. DOI: 10.1016/J.Jtho.2016.11.021 |
0.346 |
|
| 2016 |
Carlson ES, Upadhyaya P, Hecht SS. Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines. Chemical Research in Toxicology. 29: 2194-2205. PMID 27989137 DOI: 10.1021/Acs.Chemrestox.6B00384 |
0.345 |
|
| 2016 |
Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields P, al'Absi M. Reduced Nicotine Content Cigarettes and Use of Alternative Nicotine Products: Exploratory Trial. Addiction (Abingdon, England). PMID 27614097 DOI: 10.1111/Add.13603 |
0.369 |
|
| 2016 |
Fujioka N, Ransom BW, Carmella SG, Upadhyaya P, Lindgren BR, Roper-Batker A, Hatsukami DK, Fritz VA, Rohwer C, Hecht SS. Harnessing the power of cruciferous vegetables: developing a biomarker for Brassica vegetable consumption using urinary 3,3'-diindolylmethane. Cancer Prevention Research (Philadelphia, Pa.). PMID 27538743 DOI: 10.1158/1940-6207.Capr-16-0136 |
0.316 |
|
| 2016 |
Patel YM, Park SL, Carmella SG, Paiano V, Olvera N, Stram DO, Haiman CA, Le Marchand L, Hecht SS. Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. Plos One. 11: e0156203. PMID 27275760 DOI: 10.1371/Journal.Pone.0156203 |
0.373 |
|
| 2016 |
Mercincavage M, Souprountchouk V, Tang KZ, Dumont RL, Wileyto EP, Carmella SG, Hecht SS, Strasser AA. A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 27197288 DOI: 10.1158/1055-9965.Epi-15-1088 |
0.377 |
|
| 2016 |
Yershova K, Yuan JM, Wang R, Valentin L, Watson C, Gao YT, Hecht S, Stepanov I. Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study. International Journal of Cancer. PMID 27163125 DOI: 10.1002/Ijc.30178 |
0.403 |
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| 2016 |
Yuan JM, Murphy SE, Stepanov I, Wang R, Carmella SG, Nelson HH, Hatsukami DK, Hecht SS. 2-Phenethyl isothiocyanate, glutathione S-transferase M1 and T1 polymorphisms, and detoxification of volatile organic carcinogens and toxicants in tobacco smoke. Cancer Prevention Research (Philadelphia, Pa.). PMID 27099270 DOI: 10.1158/1940-6207.Capr-16-0032 |
0.409 |
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| 2016 |
Haiman CA, Patel YM, Stram DO, Carmella SG, Chen M, Wilkens LR, Le Marchand L, Hecht SS. Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort. Plos One. 11: e0150641. PMID 26959369 DOI: 10.1371/Journal.Pone.0150641 |
0.391 |
|
| 2016 |
Hecht SS, Yuan JM, Stepanov I, Murphy SE, Wang R, Allen SS, Jensen JA, Strayer L, Adams-Haduch J, Upadhyaya P, Le C, Kurzer MS, Nelson HH, Yu MC, Hatsukami DK. Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 26951845 DOI: 10.1158/1940-6207.Capr-15-0380 |
0.407 |
|
| 2016 |
Zarth AT, Upadhyaya P, Yang J, Hecht SS. DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats. Chemical Research in Toxicology. PMID 26808005 DOI: 10.1021/Acs.Chemrestox.5B00520 |
0.378 |
|
| 2016 |
Khammanivong A, Anandharaj A, Qian X, Song JM, Upadhyaya P, Balbo S, Bandyopadhyay D, Dickerson EB, Hecht SS, Kassie F. Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. Molecular Carcinogenesis. PMID 26785143 DOI: 10.1002/Mc.22459 |
0.304 |
|
| 2016 |
Narayanapillai S, von Weymarn L, Carmella S, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy S, Xing C. Dietary Dihydromethysticin (DHM) Increases Glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-Butanol (NNAL) in A/J Mice, Potentially Enhancing its Detoxification. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26744252 DOI: 10.1124/Dmd.115.068387 |
0.346 |
|
| 2016 |
Yuan J, Stepanov I, Murphy SE, Wang R, Carmella SG, Nelson HH, Hatsukami D, Hecht SS. Abstract 4347: A randomized phase 2 clinical trial of PEITC on detoxification of tobacco-specific and non-specific carcinogens and toxicants Cancer Research. 76: 4347-4347. DOI: 10.1158/1538-7445.Am2016-4347 |
0.416 |
|
| 2016 |
Hecht SS, Carmella SG, Murphy SE, Stepanov I, Balbo S, Hatsukami DK, Yuan J, Park SL, Stram DO, Haiman C, Patel Y, Le Marchand L. Tobacco smoke toxicant and carcinogen biomarkers and lung cancer susceptibility in smokers Journal of Thoracic Oncology. 11: S7-S8. DOI: 10.1016/J.Jtho.2015.12.011 |
0.339 |
|
| 2015 |
Hecht SS, Stepanov I, Carmella SG. Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines. Accounts of Chemical Research. PMID 26678241 DOI: 10.1021/Acs.Accounts.5B00472 |
0.452 |
|
| 2015 |
Yuan JM, Nelson HH, Butler LM, Carmella SG, Wang R, Kuriger-Laber JK, Adams-Haduch J, Hecht SS, Gao YT, Murphy SE. Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai Cohort Study. International Journal of Cancer. Journal International Du Cancer. PMID 26662855 DOI: 10.1002/Ijc.29963 |
0.406 |
|
| 2015 |
Yang J, Villalta PW, Upadhyaya P, Hecht SS. Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine. Chemical Research in Toxicology. PMID 26633576 DOI: 10.1021/Acs.Chemrestox.5B00425 |
0.361 |
|
| 2015 |
Kotandeniya D, Carmella SG, Pillsbury ME, Hecht SS. Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1007: 121-126. PMID 26595795 DOI: 10.1016/J.Jchromb.2015.10.012 |
0.387 |
|
| 2015 |
Wang H, Park SL, Stram DO, Haiman CA, Wilkens LR, Hecht SS, Kolonel LN, Murphy SE, Le Marchand L. Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study. American Journal of Epidemiology. PMID 26568573 DOI: 10.1093/Aje/Kwv138 |
0.334 |
|
| 2015 |
Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S. Screening for DNA Alkylation Mono and Crosslinked Adducts with a Comprehensive LC-MS(3) Adductomic Approach. Analytical Chemistry. PMID 26509677 DOI: 10.1021/Acs.Analchem.5B02759 |
0.552 |
|
| 2015 |
Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, et al. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. The New England Journal of Medicine. 373: 1340-1349. PMID 26422724 DOI: 10.1056/Nejmsa1502403 |
0.307 |
|
| 2015 |
Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS. Comprehensive High Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology. PMID 26398225 DOI: 10.1021/Acs.Chemrestox.5B00318 |
0.405 |
|
| 2015 |
Park SL, Carmella SG, Chen M, Patel Y, Stram DO, Haiman CA, Le Marchand L, Hecht SS. Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. Plos One. 10: e0124841. PMID 26053186 DOI: 10.1371/Journal.Pone.0124841 |
0.4 |
|
| 2015 |
Hatsukami DK, Severson H, Anderson A, Vogel RI, Jensen J, Broadbent B, Murphy SE, Carmella S, Hecht SS. Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching. Tobacco Control. PMID 25991608 DOI: 10.1136/Tobaccocontrol-2014-052080 |
0.329 |
|
| 2015 |
Khariwala SS, Carmella SG, Stepanov I, Bandyopadhyay D, Nelson HH, Yueh B, Hatsukami DK, Hecht SS. Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer. The Laryngoscope. 125: 1844-8. PMID 25877866 DOI: 10.1002/Lary.25290 |
0.341 |
|
| 2015 |
Hecht SS, Koh WP, Wang R, Chen M, Carmella SG, Murphy SE, Yuan JM. Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home. Plos One. 10: e0120023. PMID 25807518 DOI: 10.1371/Journal.Pone.0120023 |
0.332 |
|
| 2015 |
Zabala V, Tong M, Yu R, Ramirez T, Yalcin EB, Balbo S, Silbermann E, Deochand C, Nunez K, Hecht S, de la Monte SM. Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease. Alcohol and Alcoholism (Oxford, Oxfordshire). 50: 118-31. PMID 25618784 DOI: 10.1093/Alcalc/Agu083 |
0.322 |
|
| 2015 |
Kotandeniya D, Carmella SG, Ming X, Murphy SE, Hecht SS. Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine. Analytical Chemistry. 87: 1514-7. PMID 25544129 DOI: 10.1021/Ac504047J |
0.36 |
|
| 2015 |
Park SL, Carmella SG, Ming X, Vielguth E, Stram DO, Le Marchand L, Hecht SS. Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 561-9. PMID 25542827 DOI: 10.1158/1055-9965.Epi-14-1054 |
0.357 |
|
| 2015 |
Hatsukami DK, Stepanov I, Severson H, Jensen JA, Lindgren BR, Horn K, Khariwala SS, Martin J, Carmella SG, Murphy SE, Hecht SS. Evidence supporting product standards for carcinogens in smokeless tobacco products. Cancer Prevention Research (Philadelphia, Pa.). 8: 20-6. PMID 25524878 DOI: 10.1158/1940-6207.Capr-14-0250 |
0.391 |
|
| 2015 |
Walton KM, Abrams DB, Bailey WC, Clark D, Connolly GN, Djordjevic MV, Eissenberg TE, Fiore MC, Goniewicz ML, Haverkos L, Hecht SS, Henningfield JE, Hughes JR, Oncken CA, Postow L, et al. NIH electronic cigarette workshop: developing a research agenda. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 259-69. PMID 25335949 DOI: 10.1093/Ntr/Ntu214 |
0.3 |
|
| 2015 |
Hecht SS, Carmella SG, Kotandeniya D, Pillsbury ME, Chen M, Ransom BW, Vogel RI, Thompson E, Murphy SE, Hatsukami DK. Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 704-9. PMID 25335945 DOI: 10.1093/Ntr/Ntu218 |
0.355 |
|
| 2015 |
Upadhyaya P, Hecht SS. Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 524-9. PMID 25324430 DOI: 10.1093/Ntr/Ntu206 |
0.356 |
|
| 2015 |
Yuan J, Nelson HH, Butler LM, Carmella SG, Wang R, Adams-Haduch J, Hecht SS, Koh W, Gao Y, Murphy SE. Abstract 4595: The impact of CYP2A6 genetic polymorphisms on nicotine metabolism and lung cancer risk in two prospective cohorts of smokers Cancer Research. 75: 4595-4595. DOI: 10.1158/1538-7445.Am2015-4595 |
0.408 |
|
| 2014 |
Kassem NO, Kassem NO, Jackson SR, Liles S, Daffa RM, Zarth AT, Younis MA, Carmella SG, Hofstetter CR, Chatfield DA, Matt GE, Hecht SS, Hovell MF. Benzene uptake in Hookah smokers and non-smokers attending Hookah social events: regulatory implications. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 2793-809. PMID 25416714 DOI: 10.1158/1055-9965.Epi-14-0576 |
0.356 |
|
| 2014 |
Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats. Carcinogenesis. 35: 2798-806. PMID 25269804 DOI: 10.1093/Carcin/Bgu204 |
0.375 |
|
| 2014 |
Jing M, Wang Y, Upadhyaya P, Jain V, Yuan JM, Hatsukami DK, Hecht SS, Stepanov I. Liquid chromatography-electrospray ionization-tandem mass spectrometry quantitation of urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation in smokers. Chemical Research in Toxicology. 27: 1547-55. PMID 25098652 DOI: 10.1021/Tx5001915 |
0.403 |
|
| 2014 |
Hecht SS, Hochalter JB. Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide. Mutagenesis. 29: 351-6. PMID 25053834 DOI: 10.1093/Mutage/Geu024 |
0.355 |
|
| 2014 |
Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C. Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 35: 2365-72. PMID 25053626 DOI: 10.1093/Carcin/Bgu149 |
0.353 |
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| 2014 |
Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, ... ... Hecht SS, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research (Philadelphia, Pa.). 7: 813-23. PMID 24913818 DOI: 10.1158/1940-6207.Capr-14-0103 |
0.303 |
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| 2014 |
Hecht SS. It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco. Cancer Prevention Research (Philadelphia, Pa.). 7: 639-47. PMID 24806664 DOI: 10.1158/1940-6207.Capr-14-0095 |
0.408 |
|
| 2014 |
Zarth AT, Cheng G, Zhang Z, Wang M, Villalta PW, Balbo S, Hecht SS. Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans. Chemico-Biological Interactions. 215: 40-5. PMID 24632417 DOI: 10.1016/J.Cbi.2014.03.002 |
0.34 |
|
| 2014 |
Zarth AT, Carmella SG, Le CT, Hecht SS. Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 953: 126-31. PMID 24608133 DOI: 10.1016/J.Jchromb.2014.02.001 |
0.415 |
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| 2014 |
Kassem NO, Daffa RM, Liles S, Jackson SR, Kassem NO, Younis MA, Mehta S, Chen M, Jacob P, Carmella SG, Chatfield DA, Benowitz NL, Matt GE, Hecht SS, Hovell MF. Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 961-75. PMID 24590387 DOI: 10.1093/Ntr/Ntu016 |
0.397 |
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| 2014 |
Balbo S, Hecht SS, Upadhyaya P, Villalta PW. Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures. Analytical Chemistry. 86: 1744-52. PMID 24410521 DOI: 10.1021/Ac403565M |
0.345 |
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| 2014 |
Yuan JM, Butler LM, Stepanov I, Hecht SS. Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer. Cancer Research. 74: 401-11. PMID 24408916 DOI: 10.1158/0008-5472.Can-13-3178 |
0.43 |
|
| 2014 |
Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O'Sullivan MG, Hecht SS, Lu J, Xing C. Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 7: 86-96. PMID 24403291 DOI: 10.1158/1940-6207.Capr-13-0301 |
0.338 |
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| 2014 |
Hecht SS, Szabo E. Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer. Cancer Prevention Research (Philadelphia, Pa.). 7: 1-8. PMID 24403288 DOI: 10.1158/1940-6207.Capr-13-0371 |
0.386 |
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| 2014 |
Mallery SR, Tong M, Michaels GC, Kiyani AR, Hecht SS. Clinical and biochemical studies support smokeless tobacco's carcinogenic potential in the human oral cavity. Cancer Prevention Research (Philadelphia, Pa.). 7: 23-32. PMID 24265177 DOI: 10.1158/1940-6207.Capr-13-0262 |
0.349 |
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| 2014 |
Stepanov I, Sebero E, Wang R, Gao YT, Hecht SS, Yuan JM. Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites. International Journal of Cancer. Journal International Du Cancer. 134: 2278-83. PMID 24243522 DOI: 10.1002/Ijc.28575 |
0.403 |
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| 2014 |
Yuan JM, Butler LM, Gao YT, Murphy SE, Carmella SG, Wang R, Nelson HH, Hecht SS. Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study. Carcinogenesis. 35: 339-45. PMID 24148823 DOI: 10.1093/Carcin/Bgt352 |
0.391 |
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| 2014 |
Thomas JL, Hecht SS, Luo X, Ming X, Ahluwalia JS, Carmella SG. Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 26-32. PMID 23892827 DOI: 10.1093/Ntr/Ntt110 |
0.403 |
|
| 2014 |
Park SL, Caberto C, Tiirikainen M, Wilkens L, Stram D, Haiman CA, Hecht SS, Murphy S, Marchand LL. Abstract 4152: Differences in nicotine metabolism among five racial/ethnic groups with disparate risks for lung cancer: The multiethnic cohort study Cancer Research. 74: 4152-4152. DOI: 10.1158/1538-7445.Am2014-4152 |
0.418 |
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| 2013 |
Zhao L, Balbo S, Wang M, Upadhyaya P, Khariwala SS, Villalta PW, Hecht SS. Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study. Chemical Research in Toxicology. 26: 1526-35. PMID 24001146 DOI: 10.1021/Tx400235X |
0.386 |
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| 2013 |
Carmella SG, Chen M, Zarth A, Hecht SS. High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 935: 36-40. PMID 23934173 DOI: 10.1016/J.Jchromb.2013.07.004 |
0.366 |
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| 2013 |
Wang M, Cheng G, Khariwala SS, Bandyopadhyay D, Villalta PW, Balbo S, Hecht SS. Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation. Chemico-Biological Interactions. 206: 83-9. PMID 23911671 DOI: 10.1016/J.Cbi.2013.07.010 |
0.358 |
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| 2013 |
Carmella SG, Ming X, Olvera N, Brookmeyer C, Yoder A, Hecht SS. High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers. Chemical Research in Toxicology. 26: 1209-17. PMID 23837805 DOI: 10.1021/Tx400121N |
0.382 |
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| 2013 |
Balbo S, James-Yi S, Johnson CS, O'Sullivan MG, Stepanov I, Wang M, Bandyopadhyay D, Kassie F, Carmella S, Upadhyaya P, Hecht SS. (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. Carcinogenesis. 34: 2178-83. PMID 23671129 DOI: 10.1093/Carcin/Bgt162 |
0.391 |
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| 2013 |
Hatsukami DK, Hertsgaard LA, Vogel RI, Jensen JA, Murphy SE, Hecht SS, Carmella SG, al'Absi M, Joseph AM, Allen SS. Reduced nicotine content cigarettes and nicotine patch. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 1015-24. PMID 23603206 DOI: 10.1158/1055-9965.Epi-12-1439 |
0.388 |
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| 2013 |
Hecht SS, Hochalter JB, Carmella SG, Zhang Y, Rauch DM, Fujioka N, Jensen J, Hatsukami DK. Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 18: 144-50. PMID 23336104 DOI: 10.3109/1354750X.2012.753553 |
0.305 |
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| 2013 |
Stepanov I, Muzic J, Le CT, Sebero E, Villalta P, Ma B, Jensen J, Hatsukami D, Hecht SS. Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 26: 37-45. PMID 23252610 DOI: 10.1021/Tx300282K |
0.398 |
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| 2013 |
Stepanov I, Yershova K, Carmella S, Upadhyaya P, Hecht SS. Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 1305-10. PMID 23212437 DOI: 10.1093/Ntr/Nts249 |
0.379 |
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| 2013 |
Avila-Tang E, Al-Delaimy WK, Ashley DL, Benowitz N, Bernert JT, Kim S, Samet JM, Hecht SS. Assessing secondhand smoke using biological markers. Tobacco Control. 22: 164-71. PMID 22940677 DOI: 10.1136/Tobaccocontrol-2011-050298 |
0.393 |
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| 2013 |
Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I. Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 591-5. PMID 22923602 DOI: 10.1093/Ntr/Nts172 |
0.324 |
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| 2013 |
Hecht SS, Murphy SE, Stepanov I, Nelson HH, Yuan JM. Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study. Cancer Letters. 334: 34-8. PMID 22824243 DOI: 10.1016/J.Canlet.2012.07.016 |
0.402 |
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| 2013 |
Khariwala SS, Carmella SG, Stepanov I, Fernandes P, Lassig AA, Yueh B, Hatsukami D, Hecht SS. Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control study. Head & Neck. 35: 1096-100. PMID 22807150 DOI: 10.1002/Hed.23085 |
0.399 |
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| 2013 |
Radwan G, Hecht SS, Carmella SG, Loffredo CA. Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 130-8. PMID 22573723 DOI: 10.1093/Ntr/Nts099 |
0.397 |
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| 2013 |
Vardavas CI, Fthenou E, Patelarou E, Bagkeris E, Murphy S, Hecht SS, Connolly GN, Chatzi L, Kogevinas M. Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations. Tobacco Control. 22: 194-200. PMID 22253001 DOI: 10.1136/Tobaccocontrol-2011-050144 |
0.371 |
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| 2013 |
Balbo S, Johnson CS, Zhao L, O'Sullivan MG, Stepanov I, Wang M, Kassie F, Carmella S, Upadhyaya P, Le CT, Hecht SS. Abstract A01: Lung and pancreatic carcinogenicity and DNA binding of the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in F344 rats Cancer Prevention Research. 6. DOI: 10.1158/1940-6215.Prev-13-A01 |
0.405 |
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| 2013 |
Yuan J, Gao Y, Murphy S, Carmella SG, Wang R, Nelson HH, Hecht SS. Abstract 1502: Urinary biomarkers of polycyclic aromatic hydrocarbon and volatile organic carcinogens in relation to lung cancer development in lifelong never smokers - The Shanghai Cohort Study. Cancer Research. 73: 1502-1502. DOI: 10.1158/1538-7445.Am2013-1502 |
0.386 |
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| 2012 |
Hecht SS. Lung carcinogenesis by tobacco smoke. International Journal of Cancer. Journal International Du Cancer. 131: 2724-32. PMID 22945513 DOI: 10.1002/Ijc.27816 |
0.425 |
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| 2012 |
Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochemical and Biophysical Research Communications. 424: 18-21. PMID 22727907 DOI: 10.1016/J.Bbrc.2012.06.012 |
0.339 |
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| 2012 |
Wang J, Zhong Y, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Hecht SS, Zimmerman CL. Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation. The Journal of Pharmacology and Experimental Therapeutics. 342: 750-60. PMID 22674470 DOI: 10.1124/Jpet.112.194118 |
0.536 |
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| 2012 |
Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK, Hecht SS. Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol. Mutagenesis. 27: 485-90. PMID 22406526 DOI: 10.1093/Mutage/Ges008 |
0.301 |
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| 2012 |
Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK, Hecht SS. Kinetics of DNA adduct formation in the oral cavity after drinking alcohol. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 601-8. PMID 22301829 DOI: 10.1158/1055-9965.Epi-11-1175 |
0.337 |
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| 2012 |
Yuan JM, Gao YT, Wang R, Chen M, Carmella SG, Hecht SS. Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. Carcinogenesis. 33: 804-9. PMID 22298640 DOI: 10.1093/Carcin/Bgs026 |
0.396 |
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| 2012 |
Stepanov I, Jensen J, Biener L, Bliss RL, Hecht SS, Hatsukami DK. Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 1241-5. PMID 22259150 DOI: 10.1093/Ntr/Ntr292 |
0.352 |
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| 2012 |
Stepanov I, Biener L, Knezevich A, Nyman AL, Bliss R, Jensen J, Hecht SS, Hatsukami DK. Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 274-81. PMID 22039075 DOI: 10.1093/Ntr/Ntr209 |
0.331 |
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| 2012 |
Khariwala SS, Hatsukami D, Hecht SS. Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators. Head & Neck. 34: 441-7. PMID 21618325 DOI: 10.1002/Hed.21705 |
0.409 |
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| 2012 |
Stepanov I, Knezevich A, Zhang L, Watson CH, Hatsukami DK, Hecht SS. Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry. Tobacco Control. 21: 44-8. PMID 21602537 DOI: 10.1136/Tc.2010.042192 |
0.4 |
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| 2012 |
Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC. Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). International Journal of Cancer. Journal International Du Cancer. 130: 1338-46. PMID 21544809 DOI: 10.1002/Ijc.26162 |
0.314 |
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| 2012 |
Hecht SS. Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 18-28. PMID 21324834 DOI: 10.1093/Ntr/Ntq216 |
0.371 |
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| 2012 |
Hecht SS, James-Yi S, O'Sullivan G, Stepanov I, Wang M, Kassie F, Carmella S, Upadhyaya P, Balbo S. Abstract CN06-01: Induction of oral cavity cancer in rats by (S)-N'-nitrosonornicotine, a constituent of smokeless tobacco Cancer Prevention Research. 5: CN06-01-CN06-01. DOI: 10.1158/1940-6207.Prev-12-Cn06-01 |
0.39 |
|
| 2012 |
Fujioka N, Zhong Y, Holchalter JB, Rauch D, Jensen JJ, Le CT, Hatsukami DK, Hecht SS. Abstract A69: Pilot study of the effects of indole-3-carbinol on deuterated phenanthrene metabolism in smokers Cancer Prevention Research. 5: A69-A69. DOI: 10.1158/1940-6207.Prev-12-A69 |
0.536 |
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| 2012 |
Peiffer D, Siddiqui JH, Kuo C, Huang Y, Zimmerman NP, Wang L, Stoner GD, Carmella SG, Ransom B, Hecht SS. Abstract A49: Chemoprevention of esophageal cancer using PCA, a metabolite of black raspberry-derived anthocyanins Cancer Prevention Research. 5: A49-A49. DOI: 10.1158/1940-6207.Prev-12-A49 |
0.315 |
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| 2012 |
Balbo S, James-Yi S, O'Sullivan MG, Stepanov I, Wang M, Zhang S, Kassie F, Carmella S, Wettlaufer C, Hohol K, Knezevich A, Upadhyaya P, Hecht SS. Abstract LB-63: (S)-N′-nitrosonornicotine, a constituent of smokeless tobacco, is a potent oral tumorigen in rats Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-63 |
0.512 |
|
| 2012 |
Knezevich A, Yuan J, Carmella S, Hatsukami D, Hecht SS, Stepanov I. Abstract 667: Evaluation of toxicant exposure in U.S. smokers after short-term switching to commercial low-nitrosamine cigarettes Cancer Research. 72: 667-667. DOI: 10.1158/1538-7445.Am2012-667 |
0.404 |
|
| 2012 |
Balbo S, Villalta PW, Hecht SS. Abstract 4791: Development of a high resolution mass spectrometry method for the observation and characterization of unknown adducts in human DNA Cancer Research. 72: 4791-4791. DOI: 10.1158/1538-7445.Am2012-4791 |
0.33 |
|
| 2012 |
Carmella SG, Chen M, Han S, Briggs A, Jensen J, Hatsukami DK, Hecht SS. Correction to Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers (Chemical Research Toxicology (2009) 22, (734-741) DOI: 10.0121/tx800479s) Chemical Research in Toxicology. 25: 763. DOI: 10.1021/Tx300048H |
0.385 |
|
| 2011 |
Yuan JM, Gao YT, Murphy SE, Carmella SG, Wang R, Zhong Y, Moy KA, Davis AB, Tao L, Chen M, Han S, Nelson HH, Yu MC, Hecht SS. Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. Cancer Research. 71: 6749-57. PMID 22028322 DOI: 10.1158/0008-5472.Can-11-0209 |
0.55 |
|
| 2011 |
Balbo S, Villalta PW, Hecht SS. Quantitation of 7-ethylguanine in leukocyte DNA from smokers and nonsmokers by liquid chromatography-nanoelectrospray-high resolution tandem mass spectrometry. Chemical Research in Toxicology. 24: 1729-34. PMID 21859140 DOI: 10.1021/Tx200262D |
0.382 |
|
| 2011 |
Vogel RI, Carmella SG, Stepanov I, Hatsukami DK, Hecht SS. The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 16: 491-7. PMID 21812592 DOI: 10.3109/1354750X.2011.598565 |
0.417 |
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| 2011 |
Yuan JM, Knezevich AD, Wang R, Gao YT, Hecht SS, Stepanov I. Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. Carcinogenesis. 32: 1366-71. PMID 21734256 DOI: 10.1093/Carcin/Bgr125 |
0.406 |
|
| 2011 |
Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C. Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. The American Journal of Chinese Medicine. 39: 727-42. PMID 21721153 DOI: 10.1142/S0192415X11009202 |
0.353 |
|
| 2011 |
Hecht SS. More than 500 trillion molecules of strong carcinogens per cigarette: use in product labelling? Tobacco Control. 20: 387. PMID 21670075 DOI: 10.1136/Tc.2011.042853 |
0.377 |
|
| 2011 |
Zhong Y, Wang J, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Zimmerman C, Hecht SS. Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration. The Journal of Pharmacology and Experimental Therapeutics. 338: 353-61. PMID 21515812 DOI: 10.1124/Jpet.111.181719 |
0.544 |
|
| 2011 |
Hecht SS, Upadhyaya P, Wang M. Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes. Chemical Research in Toxicology. 24: 781-90. PMID 21480629 DOI: 10.1021/Tx200064A |
0.342 |
|
| 2011 |
Thomas JL, Guo H, Carmella SG, Balbo S, Han S, Davis A, Yoder A, Murphy SE, An LC, Ahluwalia JS, Hecht SS. Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 1213-21. PMID 21467230 DOI: 10.1158/1055-9965.Epi-10-1027 |
0.378 |
|
| 2011 |
Hochalter JB, Zhong Y, Han S, Carmella SG, Hecht SS. Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene. Chemical Research in Toxicology. 24: 262-8. PMID 21229973 DOI: 10.1021/Tx100391Z |
0.486 |
|
| 2011 |
Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE. Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 234-8. PMID 21212060 DOI: 10.1158/1055-9965.Epi-10-0674 |
0.409 |
|
| 2011 |
Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami D, Wang J, Zimmerman C, Hecht SS. Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. Chemical Research in Toxicology. 24: 246-52. PMID 21184614 DOI: 10.1021/Tx100345X |
0.565 |
|
| 2011 |
Zhang S, Balbo S, Wang M, Hecht SS. Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers. Chemical Research in Toxicology. 24: 119-24. PMID 21090699 DOI: 10.1021/Tx100321Y |
0.591 |
|
| 2011 |
Kotlyar M, Hertsgaard LA, Lindgren BR, Jensen JA, Carmella SG, Stepanov I, Murphy SE, Hecht SS, Hatsukami DK. Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 91-100. PMID 21068204 DOI: 10.1158/1055-9965.Epi-10-0349 |
0.406 |
|
| 2011 |
Zhong Y, Carmella SG, Hochalter JB, Balbo S, Hecht SS. Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation. Chemical Research in Toxicology. 24: 73-80. PMID 21049951 DOI: 10.1021/Tx100287N |
0.513 |
|
| 2011 |
Hecht SS, Stepanov I, Hatsukami DK. Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products. Tobacco Control. 20: 443. PMID 20930058 DOI: 10.1136/Tc.2010.037648 |
0.37 |
|
| 2011 |
Khariwala S, Hatsukami D, Stepanov I, Hecht S, Fernandes P, Lassig AAD, Yueh B. Elevated Urinary 1-HOP, NNN, and NNAL in Smokers with Head and Neck Squamous Cell Carcinoma Otolaryngology–Head and Neck Surgery. 145: P65-P65. DOI: 10.1177/0194599811416318A78 |
0.381 |
|
| 2011 |
Yuan J, Gao Y, Carmella SG, Wang R, Chen M, Hecht SS. Abstract A6: Urinary levels of volatile organic carcinogens and toxicant biomarkers in relation to lung cancer development in both smokers and nonsmokers: The Shanghai Cohort Study Cancer Prevention Research. 4. DOI: 10.1158/1940-6207.Prev-11-A6 |
0.407 |
|
| 2011 |
Egner PA, Chen JG, Wang JB, Friesen MD, Jacobson LP, Munoz A, Ng D, Chen TY, Fahey JW, Talalay P, Carmella SG, Hecht SS, Groopman JD, Kensler TW. Abstract LB-405: Modulation of the metabolism of air-borne pollutants by broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, People's Republic of China Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-405 |
0.321 |
|
| 2011 |
Murphy SE, Berg JZ, Wang R, Wickham KM, Gao Y, Hecht SS, Yuan J. Abstract 4656: Relationship of nicotine and carcinogen biomarkers to lung cancer risk among smokers in the Shanghai cohort study Cancer Research. 71: 4656-4656. DOI: 10.1158/1538-7445.Am2011-4656 |
0.417 |
|
| 2011 |
Yuan J, Knezevich AD, Wang R, Gao Y, Hecht SS, Stepanov I. Abstract 4652: Urinary levels of the tobacco-specific carcinogen N′-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers in the Shanghai Cohort Study Cancer Research. 71: 4652-4652. DOI: 10.1158/1538-7445.Am2011-4652 |
0.372 |
|
| 2011 |
Stepanov I, Knezevich A, Muzic J, Hatsukami DK, Hecht SS. Abstract 4650: Nornicotine nitrosation in human saliva and its relation to endogenous formation of N′-nitrosonornicotine in oral nicotine replacement therapy users Cancer Research. 71: 4650-4650. DOI: 10.1158/1538-7445.Am2011-4650 |
0.334 |
|
| 2011 |
Balbo S, Meng L, Jensen JA, Hatsukami DK, Hecht SS. Abstract 4639: Effects of defined amounts of alcohol consumption on levels of N2-ethylidene-dGuo in DNA from human buccal cells and peripheral blood nucleated cells Cancer Research. 71: 4639-4639. DOI: 10.1158/1538-7445.Am2011-4639 |
0.321 |
|
| 2011 |
Zhong Y, Wang J, Carmella SG, Upadhyaya P, Rauch D, Oliver A, Jensen J, Hatsukami D, Zimmerman C, Hecht SS. Abstract 3167: Comparison of the pharmacokinetics of phenanthrene in smokers after oral ingestion or inhalation through cigarettes for potential lung cancer susceptibility assessment Cancer Research. 71: 3167-3167. DOI: 10.1158/1538-7445.Am2011-3167 |
0.532 |
|
| 2011 |
Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC. Abstract 2758: Genetic variability in tobacco-specific nitrosamine NNK to NNAL metabolism Cancer Research. 71: 2758-2758. DOI: 10.1158/1538-7445.Am2011-2758 |
0.328 |
|
| 2010 |
Kassie F, Melkamu T, Endalew A, Upadhyaya P, Luo X, Hecht SS. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis. 31: 1634-41. PMID 20603442 DOI: 10.1093/Carcin/Bgq139 |
0.348 |
|
| 2010 |
Upadhyaya P, Hochalter JB, Balbo S, McIntee EJ, Hecht SS. Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1397-402. PMID 20547966 DOI: 10.1124/Dmd.110.034181 |
0.336 |
|
| 2010 |
Gray N, Hecht SS. Smokeless tobacco--proposals for regulation. Lancet. 375: 1589-91. PMID 20452507 DOI: 10.1016/S0140-6736(10)60516-8 |
0.302 |
|
| 2010 |
Cheng G, Wang M, Villalta PW, Hecht SS. Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA. Chemical Research in Toxicology. 23: 1089-96. PMID 20438065 DOI: 10.1021/Tx100062V |
0.338 |
|
| 2010 |
Hecht SS, Yuan JM, Hatsukami D. Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. Chemical Research in Toxicology. 23: 1001-8. PMID 20408564 DOI: 10.1021/Tx100056M |
0.406 |
|
| 2010 |
Hecht SS, Seow A, Wang M, Wang R, Meng L, Koh WP, Carmella SG, Chen M, Han S, Yu MC, Yuan JM. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1185-92. PMID 20406956 DOI: 10.1158/1055-9965.Epi-09-1291 |
0.312 |
|
| 2010 |
Church TR, Anderson KE, Le C, Zhang Y, Kampa DM, Benoit AR, Yoder AR, Carmella SG, Hecht SS. Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 15: 345-52. PMID 20374068 DOI: 10.3109/13547501003753881 |
0.328 |
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| 2010 |
Hecht SS, Carmella SG, Villalta PW, Hochalter JB. Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies. Chemical Research in Toxicology. 23: 900-8. PMID 20369855 DOI: 10.1021/Tx9004538 |
0.336 |
|
| 2010 |
Jensen JA, Schillo BA, Moilanen MM, Lindgren BR, Murphy S, Carmella S, Hecht SS, Hatsukami DK. Tobacco smoke exposure in nonsmoking hospitality workers before and after a state smoking ban. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1016-21. PMID 20354127 DOI: 10.1158/1055-9965.Epi-09-0969 |
0.392 |
|
| 2010 |
Maertens LA, Upadhyaya P, Hecht SS, Zimmerman CL. Formation and distribution of NNK metabolites in an isolated perfused rat lung. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 752-60. PMID 20159989 DOI: 10.1124/Dmd.109.031492 |
0.381 |
|
| 2010 |
Thomas JL, An L, Luo X, Scherber RM, Berg CJ, Golden D, Ehlinger EP, Murphy SE, Hecht SS, Ahluwalia JS. Abstinence and relapse rates following a college campus-based quit & win contest. Journal of American College Health : J of Ach. 58: 365-72. PMID 20159760 DOI: 10.1080/07448480903380268 |
0.349 |
|
| 2010 |
Hatsukami DK, Kotlyar M, Hertsgaard LA, Zhang Y, Carmella SG, Jensen JA, Allen SS, Shields PG, Murphy SE, Stepanov I, Hecht SS. Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction (Abingdon, England). 105: 343-55. PMID 20078491 DOI: 10.1111/J.1360-0443.2009.02780.X |
0.377 |
|
| 2010 |
Stepanov I, Villalta PW, Knezevich A, Jensen J, Hatsukami D, Hecht SS. Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry. Chemical Research in Toxicology. 23: 66-73. PMID 19860436 DOI: 10.1021/Tx900281U |
0.376 |
|
| 2010 |
Kassie F, Kalscheuer S, Matise I, Ma L, Melkamu T, Upadhyaya P, Hecht SS. Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. Carcinogenesis. 31: 239-45. PMID 19625346 DOI: 10.1093/Carcin/Bgp174 |
0.334 |
|
| 2010 |
Hecht SS, Carmella SG, Zhong Y, Chen M, Upadhyaya P, Hochalter JB, Rauch D, Jensen J, Hatsukami D, Yuan J. Abstract CN07-02: Polycyclic aromatic hydrocarbon tetraols: Potential phenotypic indicators of lung cancer susceptibility in smokers Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-Cn07-02 |
0.567 |
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| 2010 |
Thomas JL, Guo H, Wang Q, Han S, Carmella SC, Murphy SE, Ahluwalia JS, Hecht SS. Abstract B89: Child second-hand and third-hand exposure to carcinogens and tobacco toxicants Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-B89 |
0.351 |
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| 2010 |
Xing C, Johnson T, Hermanson D, Kassie F, Upadhyaya P, O'Sullivan M, Hecht S. Abstract A70: Kava as a lung cancer chemopreventive agent Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A70 |
0.329 |
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| 2010 |
Yuan J, Gao Y, Carmella SG, Wang R, Zhong Y, Tao L, Davis AB, Moy KA, Chen M, Han S, Yu MC, Hecht SS. Abstract 863: Urinary levels of a polycyclic aromatic hydrocarbon metabolite in relation to lung cancer development in cigarette smokers of the Shanghai Cohort Study Cancer Research. 70: 863-863. DOI: 10.1158/1538-7445.Am10-863 |
0.549 |
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| 2010 |
Upadhyaya P, Hochalter JB, Balbo S, Berg JZ, McIntee EJ, Hecht SS. Abstract 4698: Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of benzo[a]pyrene in human hepatocytes: Relevance to glutathione-S-transferase genotyping in epidemiology studies Cancer Research. 70: 4698-4698. DOI: 10.1158/1538-7445.Am10-4698 |
0.365 |
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| 2010 |
Carmella SG, Hecht SS, Seow A, Wang M, Wang R, Meng L, Koh W, Chen M, Han S, Yu MC, Yuan J. Abstract 4695: Elevated levels of biomarkers of volatile organic carcinogens and toxicants in Chinese women who regularly cook at home Cancer Research. 70: 4695-4695. DOI: 10.1158/1538-7445.Am10-4695 |
0.361 |
|
| 2010 |
Maertens LA, Upadhyaya P, Hecht SS, Zimmerman CL. Abstract 1696: Metabolism of (S)-NNAL and (R)-NNAL in the isolated perfused rat lung system Cancer Research. 70: 1696-1696. DOI: 10.1158/1538-7445.Am10-1696 |
0.352 |
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| 2010 |
Hecht SS, Carmella SG, Hochalter JB. Abstract 1690: Analysis of benzo[a]pyrene and phenanthrene tetraol enantiomers in human urine: Relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies Cancer Research. 70: 1690-1690. DOI: 10.1158/1538-7445.Am10-1690 |
0.34 |
|
| 2010 |
Wang M, Cheng G, Chen L, Villalta PW, Hecht SS. Abstract 1689: Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis for 7-carboxymethylguanine and 7-carboxyethylguanine in human liver DNA Cancer Research. 70: 1689-1689. DOI: 10.1158/1538-7445.Am10-1689 |
0.375 |
|
| 2009 |
Stepanov I, Carmella SG, Briggs A, Hertsgaard L, Lindgren B, Hatsukami D, Hecht SS. Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. Cancer Research. 69: 8236-40. PMID 19843845 DOI: 10.1158/0008-5472.Can-09-1084 |
0.409 |
|
| 2009 |
Loureiro AP, Zhang W, Kassie F, Zhang S, Villalta PW, Wang M, Hecht SS. Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA. Chemical Research in Toxicology. 22: 1728-35. PMID 19761253 DOI: 10.1021/Tx900238T |
0.527 |
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| 2009 |
Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS. Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. Cancer Research. 69: 7170-4. PMID 19738046 DOI: 10.1158/0008-5472.Can-09-1571 |
0.43 |
|
| 2009 |
Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA. The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chemical Research in Toxicology. 22: 1464-72. PMID 19601657 DOI: 10.1021/Tx9001572 |
0.559 |
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| 2009 |
Derby KS, Cuthrell K, Caberto C, Carmella S, Murphy SE, Hecht SS, Le Marchand L. Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. International Journal of Cancer. Journal International Du Cancer. 125: 2418-24. PMID 19598261 DOI: 10.1002/Ijc.24585 |
0.398 |
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| 2009 |
Hecht SS, Kassie F, Hatsukami DK. Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers. Nature Reviews. Cancer. 9: 476-88. PMID 19550424 DOI: 10.1038/Nrc2674 |
0.392 |
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| 2009 |
Zhang S, Wang M, Villalta PW, Lindgren BR, Lao Y, Hecht SS. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical Research in Toxicology. 22: 949-56. PMID 19405515 DOI: 10.1021/Tx900040J |
0.676 |
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| 2009 |
Zhang S, Wang M, Villalta PW, Lindgren BR, Upadhyaya P, Lao Y, Hecht SS. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 22: 926-36. PMID 19358518 DOI: 10.1021/Tx900015D |
0.666 |
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| 2009 |
Upadhyaya P, Lindgren BR, Hecht SS. Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1147-51. PMID 19324941 DOI: 10.1124/Dmd.109.027078 |
0.375 |
|
| 2009 |
Yuan JM, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, Han S, Wickham K, Gao YT, Yu MC, Hecht SS. Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Research. 69: 2990-5. PMID 19318550 DOI: 10.1158/0008-5472.Can-08-4330 |
0.39 |
|
| 2009 |
Carmella SG, Chen M, Han S, Briggs A, Jensen J, Hatsukami DK, Hecht SS. Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. Chemical Research in Toxicology. 22: 734-41. PMID 19317515 DOI: 10.1021/Tx800479S |
0.427 |
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| 2009 |
Stepanov I, Carmella SG, Han S, Pinto A, Strasser AA, Lerman C, Hecht SS. Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 11: 99-105. PMID 19246447 DOI: 10.1093/Ntr/Ntn004 |
0.354 |
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| 2009 |
Hecht SS, Berg JZ, Hochalter JB. Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer. Chemical Research in Toxicology. 22: 426-32. PMID 19187038 DOI: 10.1021/Tx800315M |
0.359 |
|
| 2009 |
Stepanov I, Hecht SS. Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 22: 406-14. PMID 19166332 DOI: 10.1021/Tx800398X |
0.38 |
|
| 2009 |
Church TR, Anderson KE, Caporaso NE, Geisser MS, Le CT, Zhang Y, Benoit AR, Carmella SG, Hecht SS. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 260-6. PMID 19124507 DOI: 10.1158/1055-9965.Epi-08-0718 |
0.401 |
|
| 2008 |
Kassie F, Matise I, Negia M, Upadhyaya P, Hecht SS. Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. Cancer Prevention Research (Philadelphia, Pa.). 1: 568-76. PMID 19139007 DOI: 10.1158/1940-6207.Capr-08-0064 |
0.329 |
|
| 2008 |
Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, Upadhyaya P, Ruvolo PP, Hecht SS, Xing C. Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 430-8. PMID 19138990 DOI: 10.1158/1940-6207.Capr-08-0027 |
0.329 |
|
| 2008 |
Kassie F, Matise I, Negia M, Lahti D, Pan Y, Scherber R, Upadhyaya P, Hecht SS. Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 285-97. PMID 19138972 DOI: 10.1158/1940-6207.Capr-08-0012 |
0.391 |
|
| 2008 |
Hertsgaard LA, Hanson K, Hecht SS, Lindgren BR, Luo X, Carmella SG, Riley WT, Zylla EB, Murphy SE, Hatsukami DK. Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3337-43. PMID 19064548 DOI: 10.1158/1055-9965.Epi-08-0307 |
0.381 |
|
| 2008 |
Derby KS, Cuthrell K, Caberto C, Carmella SG, Franke AA, Hecht SS, Murphy SE, Le Marchand L. Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3526-35. PMID 19029401 DOI: 10.1158/1055-9965.Epi-08-0424 |
0.416 |
|
| 2008 |
Stepanov I, Jensen J, Hatsukami D, Hecht SS. New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 1773-82. PMID 19023828 DOI: 10.1080/14622200802443544 |
0.372 |
|
| 2008 |
Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Research. 68: 9137-40. PMID 19010884 DOI: 10.1158/0008-5472.Can-08-2271 |
0.412 |
|
| 2008 |
Balbo S, Hashibe M, Gundy S, Brennan P, Canova C, Simonato L, Merletti F, Richiardi L, Agudo A, Castellsagué X, Znaor A, Talamini R, Bencko V, Holcátová I, Wang M, ... Hecht SS, et al. N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3026-32. PMID 18990745 DOI: 10.1158/1055-9965.Epi-08-0117 |
0.341 |
|
| 2008 |
Upadhyaya P, Hecht SS. Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA. Chemical Research in Toxicology. 21: 2164-71. PMID 18821782 DOI: 10.1021/Tx8002559 |
0.413 |
|
| 2008 |
Stepanov I, Upadhyaya P, Carmella SG, Feuer R, Jensen J, Hatsukami DK, Hecht SS. Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 1764-73. PMID 18628430 DOI: 10.1158/1055-9965.Epi-07-2844 |
0.399 |
|
| 2008 |
Boffetta P, Hecht S, Gray N, Gupta P, Straif K. Smokeless tobacco and cancer The Lancet Oncology. 9: 667-675. PMID 18598931 DOI: 10.1016/S1470-2045(08)70173-6 |
0.347 |
|
| 2008 |
Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 21: 1468-76. PMID 18570389 DOI: 10.1021/Tx8001109 |
0.401 |
|
| 2008 |
Hecht SS, Villalta PW, Hochalter JB. Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms. Carcinogenesis. 29: 937-43. PMID 18477646 DOI: 10.1093/Carcin/Bgn015 |
0.345 |
|
| 2008 |
Stepanov I, Hecht SS. Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 945-8. PMID 18398035 DOI: 10.1158/1055-9965.Epi-07-2711 |
0.414 |
|
| 2008 |
Burns DM, Dybing E, Gray N, Hecht S, Anderson C, Sanner T, O'Connor R, Djordjevic M, Dresler C, Hainaut P, Jarvis M, Opperhuizen A, Straif K. Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tobacco Control. 17: 132-41. PMID 18375736 DOI: 10.1136/Tc.2007.024158 |
0.397 |
|
| 2008 |
Hecht SS, Carmella SG, Edmonds A, Murphy SE, Stepanov I, Luo X, Hatsukami DK. Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco. Tobacco Control. 17: 128-31. PMID 18375734 DOI: 10.1136/Tc.2007.023242 |
0.357 |
|
| 2008 |
Hecht SS, Carmella SG, Stepanov I, Jensen J, Anderson A, Hatsukami DK. Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 732-5. PMID 18349296 DOI: 10.1158/1055-9965.Epi-07-2843 |
0.394 |
|
| 2008 |
Joseph AM, Hecht SS, Murphy SE, Lando H, Carmella SG, Gross M, Bliss R, Le CT, Hatsukami DK. Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 471-81. PMID 18324566 DOI: 10.1080/14622200801901948 |
0.372 |
|
| 2008 |
Cheng G, Wang M, Upadhyaya P, Villalta PW, Hecht SS. Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA). Chemical Research in Toxicology. 21: 746-51. PMID 18205321 DOI: 10.1021/Tx7003823 |
0.359 |
|
| 2008 |
Kassie F, Anderson LB, Higgins L, Pan Y, Matise I, Negia M, Upadhyaya P, Wang M, Hecht SS. Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. Carcinogenesis. 29: 610-9. PMID 18192687 DOI: 10.1093/Carcin/Bgn014 |
0.313 |
|
| 2008 |
Hatsukami DK, Ebbert JO, Edmonds A, Li C, Lin H, Le C, Hecht SS. Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 77-85. PMID 18188748 DOI: 10.1080/14622200701704897 |
0.345 |
|
| 2008 |
Mendoza-Baumgart MI, Tulunay OE, Hecht SS, Zhang Y, Murphy S, Le C, Jensen J, Hatsukami DK. Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: 1309-23. PMID 18058349 DOI: 10.1080/14622200701704228 |
0.381 |
|
| 2008 |
Hecht SS. Progress and challenges in selected areas of tobacco carcinogenesis Chemical Research in Toxicology. 21: 160-171. PMID 18052103 DOI: 10.1021/Tx7002068 |
0.423 |
|
| 2008 |
Hatsukami DK, Ebbert JO, Feuer RM, Stepanov I, Hecht SS. Changing smokeless tobacco products new tobacco-delivery systems. American Journal of Preventive Medicine. 33: S368-78. PMID 18021912 DOI: 10.1016/J.Amepre.2007.09.005 |
0.383 |
|
| 2008 |
Liu X, Moody EC, Hecht SS, Sturla SJ. Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity. Bioorganic & Medicinal Chemistry. 16: 3419-27. PMID 17981044 DOI: 10.1016/J.Bmc.2007.10.032 |
0.511 |
|
| 2008 |
Wang M, Cheng G, Villalta PW, Hecht* SS. Development of Liquid Chromatograpy Electrospray Ionization Tandem Mass Spectrometry Methods for Analysis of DNA Adducts of Formaldehyde and Their Application to Rats Treated withN-Nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology. 21: 555-555. DOI: 10.1021/Tx700407K |
0.304 |
|
| 2007 |
Hatsukami DK, Joseph AM, Lesage M, Jensen J, Murphy SE, Pentel PR, Kotlyar M, Borgida E, Le C, Hecht SS. Developing the science base for reducing tobacco harm. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: S537-53. PMID 18067031 DOI: 10.1080/14622200701679040 |
0.37 |
|
| 2007 |
Chen L, Wang M, Villalta PW, Hecht SS. Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human liver DNA. Chemical Research in Toxicology. 20: 1498-502. PMID 17887725 DOI: 10.1021/Tx700147F |
0.366 |
|
| 2007 |
Spector LG, Hecht SS, Ognjanovic S, Carmella SG, Ross JA. Detection of cotinine in newborn dried blood spots. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1902-5. PMID 17855712 DOI: 10.1158/1055-9965.Epi-07-0230 |
0.316 |
|
| 2007 |
Lubin JH, Caporaso N, Hatsukami DK, Joseph AM, Hecht SS. The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1852-7. PMID 17855705 DOI: 10.1158/1055-9965.Epi-07-0018 |
0.375 |
|
| 2007 |
Hecht SS, Carmella SG, Murphy SE, Riley WT, Le C, Luo X, Mooney M, Hatsukami DK. Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1567-72. PMID 17684130 DOI: 10.1158/1055-9965.Epi-07-0227 |
0.392 |
|
| 2007 |
Wang M, Cheng G, Villalta PW, Hecht SS. Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology. 20: 1141-8. PMID 17676814 DOI: 10.1021/Tx700189C |
0.38 |
|
| 2007 |
Porubin D, Hecht SS, Li ZZ, Gonta M, Stepanov I. Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract. Journal of Agricultural and Food Chemistry. 55: 7199-204. PMID 17637060 DOI: 10.1021/Jf0712191 |
0.35 |
|
| 2007 |
Stepanov I, Hecht SS, Lindgren B, Jacob P, Wilson M, Benowitz NL. Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1382-6. PMID 17627002 DOI: 10.1158/1055-9965.Epi-07-0145 |
0.382 |
|
| 2007 |
Kassie F, Anderson LB, Scherber R, Yu N, Lahti D, Upadhyaya P, Hecht SS. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. Cancer Research. 67: 6502-11. PMID 17616712 DOI: 10.1158/0008-5472.Can-06-4438 |
0.309 |
|
| 2007 |
Stark MJ, Rohde K, Maher JE, Pizacani BA, Dent CW, Bard R, Carmella SG, Benoit AR, Thomson NM, Hecht SS. The impact of clean indoor air exemptions and preemption policies on the prevalence of a tobacco-specific lung carcinogen among nonsmoking bar and restaurant workers. American Journal of Public Health. 97: 1457-63. PMID 17600262 DOI: 10.2105/Ajph.2006.094086 |
0.324 |
|
| 2007 |
Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF. Cancer prevention with freeze-dried berries and berry components. Seminars in Cancer Biology. 17: 403-10. PMID 17574861 DOI: 10.1016/J.Semcancer.2007.05.001 |
0.311 |
|
| 2007 |
Carmella SG, Chen M, Zhang Y, Zhang S, Hatsukami DK, Hecht SS. Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking. Chemical Research in Toxicology. 20: 986-90. PMID 17559234 DOI: 10.1021/Tx700075Y |
0.585 |
|
| 2007 |
McNiel EA, Carmella SG, Heath LA, Bliss RL, Le KA, Hecht SS. Urinary biomarkers to assess exposure of cats to environmental tobacco smoke. American Journal of Veterinary Research. 68: 349-53. PMID 17397288 DOI: 10.2460/Ajvr.68.4.349 |
0.375 |
|
| 2007 |
Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Nishikawa A, Hecht SS. Analysis of adducts in hepatic DNA of rats treated with N-nitrosopyrrolidine. Chemical Research in Toxicology. 20: 634-40. PMID 17394361 DOI: 10.1021/Tx600333E |
0.594 |
|
| 2007 |
Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Hecht SS. Identification of adducts formed in the reaction of alpha-acetoxy-N-nitrosopyrrolidine with deoxyribonucleosides and DNA. Chemical Research in Toxicology. 20: 625-33. PMID 17394360 DOI: 10.1021/Tx600332P |
0.597 |
|
| 2007 |
Zhang S, Villalta PW, Wang M, Hecht SS. Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 20: 565-71. PMID 17385896 DOI: 10.1021/Tx700023Z |
0.534 |
|
| 2007 |
Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS. Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine. Chemical Research in Toxicology. 20: 246-56. PMID 17305408 DOI: 10.1021/Tx060208J |
0.594 |
|
| 2007 |
Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 20: 235-45. PMID 17305407 DOI: 10.1021/Tx060207R |
0.598 |
|
| 2007 |
Hecht SS, Han S, Kenney PM, Wang M, Lindgren B, Wang Y, Lao Y, Hochalter JB, Upadhyaya P. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chemical Research in Toxicology. 20: 543-9. PMID 17291014 DOI: 10.1021/Tx600328E |
0.622 |
|
| 2007 |
Hatsukami D, Mooney M, Murphy S, LeSage M, Babb D, Hecht S. Effects of high dose transdermal nicotine replacement in cigarette smokers Pharmacology Biochemistry and Behavior. 86: 132-139. PMID 17267026 DOI: 10.1016/J.Pbb.2006.12.017 |
0.392 |
|
| 2007 |
Chen L, Wang M, Villalta PW, Luo X, Feuer R, Jensen J, Hatsukami DK, Hecht SS. Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation. Chemical Research in Toxicology. 20: 108-13. PMID 17226933 DOI: 10.1021/Tx060232X |
0.443 |
|
| 2007 |
Stepanov I, Feuer R, Jensen J, Hatsukami D, Hecht SS. Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 2378-83. PMID 17164359 DOI: 10.1158/1055-9965.Epi-06-0265 |
0.41 |
|
| 2006 |
Hatsukami DK, Le CT, Zhang Y, Joseph AM, Mooney ME, Carmella SG, Hecht SS. Toxicant exposure in cigarette reducers versus light smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 2355-8. PMID 17164356 DOI: 10.1158/1055-9965.Epi-06-0240 |
0.375 |
|
| 2006 |
Hecht SS. Smoking and lung cancer - A new role for an old toxicant? Proceedings of the National Academy of Sciences of the United States of America. 103: 15725-15726. PMID 17043212 DOI: 10.1073/Pnas.0607811103 |
0.428 |
|
| 2006 |
Liu X, Lao Y, Yang IY, Hecht SS, Moriya M. Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity. Biochemistry. 45: 12898-905. PMID 17042508 DOI: 10.1021/Bi060792V |
0.555 |
|
| 2006 |
Zhang S, Villalta PW, Wang M, Hecht SS. Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology. 19: 1386-92. PMID 17040109 DOI: 10.1021/Tx060154D |
0.517 |
|
| 2006 |
Hecht SS, Carmella SG, Yoder A, Chen M, Li ZZ, Le C, Dayton R, Jensen J, Hatsukami DK. Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1805-11. PMID 17035385 DOI: 10.1158/1055-9965.Epi-06-0173 |
0.343 |
|
| 2006 |
Hecht SS. Cigarette smoking: Cancer risks, carcinogens, and mechanisms Langenbeck's Archives of Surgery. 391: 603-613. PMID 17031696 DOI: 10.1007/S00423-006-0111-Z |
0.386 |
|
| 2006 |
Hecht SS. A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer Preventive Medicine. 43: 256-260. PMID 16997360 DOI: 10.1016/J.Ypmed.2006.07.020 |
0.401 |
|
| 2006 |
Hatsukami DK, Ebbert JO, Anderson A, Lin H, Le C, Hecht SS. Smokeless tobacco brand switching: a means to reduce toxicant exposure? Drug and Alcohol Dependence. 87: 217-24. PMID 16996230 DOI: 10.1016/J.Drugalcdep.2006.08.021 |
0.3 |
|
| 2006 |
Upadhyaya P, Rao P, Hochalter JB, Li ZZ, Villalta PW, Hecht SS. Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers. Chemical Research in Toxicology. 19: 1234-40. PMID 16978029 DOI: 10.1021/Tx060096W |
0.37 |
|
| 2006 |
Hatsukami DK, Benowitz NL, Rennard SI, Oncken C, Hecht SS. Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 8: 600-22. PMID 16920658 DOI: 10.1080/14622200600858166 |
0.358 |
|
| 2006 |
Carmella SG, Yoder A, Hecht SS. Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1490-4. PMID 16896038 DOI: 10.1158/1055-9965.Epi-06-0199 |
0.363 |
|
| 2006 |
Stein S, Lao Y, Yang IY, Hecht SS, Moriya M. Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. Mutation Research. 608: 1-7. PMID 16797223 DOI: 10.1016/J.Mrgentox.2006.01.009 |
0.567 |
|
| 2006 |
Stepanov I, Jensen J, Hatsukami D, Hecht SS. Tobacco-specific nitrosamines in new tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 8: 309-13. PMID 16766423 DOI: 10.1080/14622200500490151 |
0.34 |
|
| 2006 |
Hatsukami DK, Benowitz NL, Rennard SI, Oncken C, Hecht SS. Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 8: 169-91. PMID 16766411 DOI: 10.1080/14622200600576628 |
0.358 |
|
| 2006 |
Hecht SS, Carmella SG, Le KA, Murphy SE, Boettcher AJ, Le C, Koopmeiners J, An L, Hennrikus DJ. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 988-92. PMID 16702381 DOI: 10.1158/1055-9965.Epi-05-0596 |
0.343 |
|
| 2006 |
Lao Y, Villalta PW, Sturla SJ, Wang M, Hecht SS. Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 19: 674-82. PMID 16696570 DOI: 10.1021/Tx050351X |
0.692 |
|
| 2006 |
Upadhyaya P, McIntee EJ, Villalta PW, Hecht SS. Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA. Chemical Research in Toxicology. 19: 426-35. PMID 16544948 DOI: 10.1021/Tx050323E |
0.386 |
|
| 2006 |
Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis. 27: 1617-26. PMID 16522666 DOI: 10.1093/Carcin/Bgi366 |
0.531 |
|
| 2006 |
Stepanov I, Hecht SS, Duca G, Mardari I. Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 7-11. PMID 16434579 DOI: 10.1158/1055-9965.Epi-05-0293 |
0.377 |
|
| 2006 |
Hecht SS, Murphy SE, Carmella SG, Li S, Jensen J, Le C, Joseph AM, Hatsukami DK. Erratum: Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes (Cancer Epidemiology Biomarkers and Prevention (March 2005) 14 (693-698)) Cancer Epidemiology, Biomarkers & Prevention. 15. DOI: 10.1158/1055-9965.Epi-15-8Cor |
0.368 |
|
| 2005 |
Hecht SS, Chen M, Yoder A, Jensen J, Hatsukami D, Le C, Carmella SG. Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2969-74. PMID 16365018 DOI: 10.1158/1055-9965.Epi-05-0396 |
0.417 |
|
| 2005 |
Joseph AM, Hecht SS, Murphy SE, Carmella SG, Le CT, Zhang Y, Han S, Hatsukami DK. Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2963-8. PMID 16365017 DOI: 10.1158/1055-9965.Epi-04-0768 |
0.407 |
|
| 2005 |
Hecht SS. Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens Journal of the National Cancer Institute. 97: 1634-1635. PMID 16288111 DOI: 10.1093/Jnci/Dji414 |
0.397 |
|
| 2005 |
Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, ... ... Hecht SS, et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2605-13. PMID 16284385 DOI: 10.1158/1055-9965.Epi-05-0368 |
0.326 |
|
| 2005 |
Stepanov I, Hecht SS, Mirvish SS, Gonta M. Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco. Journal of Agricultural and Food Chemistry. 53: 8082-6. PMID 16190674 DOI: 10.1021/Jf050747E |
0.413 |
|
| 2005 |
Conaway CC, Wang CX, Pittman B, Yang YM, Schwartz JE, Tian D, McIntee EJ, Hecht SS, Chung FL. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Research. 65: 8548-57. PMID 16166336 DOI: 10.1158/0008-5472.Can-05-0237 |
0.351 |
|
| 2005 |
Lemmonds CA, Hecht SS, Jensen JA, Murphy SE, Carmella SG, Zhang Y, Hatsukami DK. Smokeless tobacco topography and toxin exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 7: 469-74. PMID 16085515 DOI: 10.1080/14622200500135640 |
0.38 |
|
| 2005 |
Dietrich M, Block G, Pogoda JM, Buffler P, Hecht S, Preston-Martin S. A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors. Cancer Causes & Control : Ccc. 16: 619-35. PMID 16049800 DOI: 10.1007/S10552-005-0168-Y |
0.303 |
|
| 2005 |
Sturla SJ, Scott J, Lao Y, Hecht SS, Villalta PW. Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology. 18: 1048-55. PMID 15962940 DOI: 10.1021/Tx050028U |
0.704 |
|
| 2005 |
Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes. Chemical Research in Toxicology. 18: 913-8. PMID 15962925 DOI: 10.1021/Tx0500777 |
0.573 |
|
| 2005 |
Hecht SS. Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: Old and new Carcinogenesis. 26: 1488-1492. PMID 15930027 DOI: 10.1093/Carcin/Bgi148 |
0.404 |
|
| 2005 |
Tulunay OE, Hecht SS, Carmella SG, Zhang Y, Lemmonds C, Murphy S, Hatsukami DK. Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers Cancer Epidemiology Biomarkers and Prevention. 14: 1283-1286. PMID 15894687 DOI: 10.1158/1055-9965.Epi-04-0570 |
0.421 |
|
| 2005 |
Lao Y, Hecht SS. Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link. Chemical Research in Toxicology. 18: 711-21. PMID 15833031 DOI: 10.1021/Tx0497292 |
0.552 |
|
| 2005 |
Kelley MJ, Glaser EM, Herndon JE, Becker F, Bhagat R, Zhang YJ, Santella RM, Carmella SG, Hecht SS, Gallot L, Schilder L, Crowell JA, Perloff M, Folz RJ, Bergan RC. Safety and efficacy of weekly oral oltipraz in chronic smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 892-9. PMID 15824161 DOI: 10.1158/1055-9965.Epi-04-0585 |
0.414 |
|
| 2005 |
Stepanov I, Hecht SS. Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 885-91. PMID 15824160 DOI: 10.1158/1055-9965.Epi-04-0753 |
0.377 |
|
| 2005 |
Hecht SS, Murphy SE, Carmella SG, Li S, Jensen J, Le C, Joseph AM, Hatsukami DK. Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 693-8. PMID 15767351 DOI: 10.1158/1055-9965.Epi-04-0542 |
0.412 |
|
| 2005 |
Kim JY, Hecht SS, Mukherjee S, Carmella SG, Rodrigues EG, Christiani DC. A urinary metabolite of phenanthrene as a biomarker of polycyclic aromatic hydrocarbon metabolic activation in workers exposed to residual oil fly ash. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 687-92. PMID 15767350 DOI: 10.1158/1055-9965.Epi-04-0428 |
0.354 |
|
| 2005 |
Stepanov I, Hecht SS, Ramakrishnan S, Gupta PC. Tobacco-specific nitrosamines in smokeless tobacco products marketed in India. International Journal of Cancer. 116: 16-9. PMID 15756678 DOI: 10.1002/Ijc.20966 |
0.389 |
|
| 2005 |
Jalas JR, Hecht SS, Murphy SE. Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. Chemical Research in Toxicology. 18: 95-110. PMID 15720112 DOI: 10.1021/Tx049847P |
0.304 |
|
| 2005 |
Wong HL, Murphy SE, Hecht SS. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chemical Research in Toxicology. 18: 61-9. PMID 15651850 DOI: 10.1021/Tx0497696 |
0.574 |
|
| 2005 |
Hecht SS. Erratum: Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: Old and new (Carcinogenesis (2005) vol. 26 (1488-1492)) Carcinogenesis. 26. DOI: 10.1093/Carcin/Bgi239 |
0.38 |
|
| 2004 |
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Seminars in Cancer Biology. 14: 473-86. PMID 15489140 DOI: 10.1016/J.Semcancer.2004.06.010 |
0.394 |
|
| 2004 |
Jalas JR, Seetharaman M, Hecht SS, Murphy SE. Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 34: 515-33. PMID 15277013 DOI: 10.1080/00498250410001713131 |
0.334 |
|
| 2004 |
Hughes JR, Hecht SS, Carmella SG, Murphy SE, Callas P. Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni. Tobacco Control. 13: 175-9. PMID 15175536 DOI: 10.1136/Tc.2003.005439 |
0.37 |
|
| 2004 |
Hatsukami DK, Lemmonds C, Zhang Y, Murphy SE, Le C, Carmella SG, Hecht SS. Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. Journal of the National Cancer Institute. 96: 844-52. PMID 15173268 DOI: 10.1093/Jnci/Djh163 |
0.325 |
|
| 2004 |
Hecht SS, Villalta PW, Sturla SJ, Cheng G, Yu N, Upadhyaya P, Wang M. Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA. Chemical Research in Toxicology. 17: 588-97. PMID 15144215 DOI: 10.1021/Tx034263T |
0.602 |
|
| 2004 |
Sexton K, Adgate JL, Church TR, Hecht SS, Ramachandran G, Greaves IA, Fredrickson AL, Ryan AD, Carmella SG, Geisser MS. Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences. Environmental Health Perspectives. 112: 392-7. PMID 14998759 DOI: 10.1289/Ehp.6473 |
0.363 |
|
| 2004 |
Zimmerman CL, Wu Z, Upadhyaya P, Hecht SS. Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis. 25: 1237-42. PMID 14988218 DOI: 10.1093/Carcin/Bgh120 |
0.337 |
|
| 2004 |
Hecht SS. Carcinogen derived biomarkers: Applications in studies of human exposure to secondhand tobacco smoke Tobacco Control. 13. PMID 14985617 DOI: 10.1136/Tc.2002.002816 |
0.434 |
|
| 2004 |
Hecht SS, Murphy SE, Carmella SG, Zimmerman CL, Losey L, Kramarczuk I, Roe MR, Puumala SS, Li YS, Le C, Jensen J, Hatsukami DK. Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen. Journal of the National Cancer Institute. 96: 107-15. PMID 14734700 DOI: 10.1093/Jnci/Djh016 |
0.408 |
|
| 2004 |
Henn SA, Succop P, Talaska G, Anderson K, Hecht SS, Gross M. Carcinogen-DNA adducts are increased in the exfoliated urothelial cells of wives of smokers: Biological monitoring of passive smoke exposure Polycyclic Aromatic Compounds. 24: 475-485. DOI: 10.1080/10406630490471492 |
0.437 |
|
| 2004 |
Hecht SS. Correction: Tobacco carcinogens, their biomarkers and tobacco-induced cancer Nature Reviews Cancer. 4: 84-84. DOI: 10.1038/Nrc1272 |
0.336 |
|
| 2003 |
Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer Nature Reviews Cancer. 3: 733-744. PMID 14570033 DOI: 10.1038/Nrc1190 |
0.37 |
|
| 2003 |
Wong HL, Murphy SE, Hecht SS. Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes. Chemical Research in Toxicology. 16: 1298-305. PMID 14565771 DOI: 10.1021/Tx0340495 |
0.604 |
|
| 2003 |
Jalas JR, McIntee EJ, Kenney PM, Upadhyaya P, Peterson LA, Hecht SS. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology. 16: 794-806. PMID 12807363 DOI: 10.1021/Tx034022L |
0.346 |
|
| 2003 |
Jalas JR, Hecht SS. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5. Chemical Research in Toxicology. 16: 782-93. PMID 12807362 DOI: 10.1021/Tx034021T |
0.357 |
|
| 2003 |
Hatsukami DK, Hecht SS, Hennrikus DJ, Joseph AM, Pentel PR. Biomakers of tobacco exposure or harm: Application to clinical and epidemiological studies Nicotine and Tobacco Research. 5: 387-396. PMID 12791522 DOI: 10.1080/1462220031000094222 |
0.344 |
|
| 2003 |
Wang M, Cheng G, Sturla SJ, Shi Y, McIntee EJ, Villalta PW, Upadhyaya P, Hecht SS. Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. Chemical Research in Toxicology. 16: 616-26. PMID 12755591 DOI: 10.1021/Tx034003B |
0.603 |
|
| 2003 |
Hatsukami DK, Edmonds A, Schulte S, Jensen J, Le CT, Losey L, Carmella SG, Hecht SS. Preliminary study on reducing oral moist snuff use. Drug and Alcohol Dependence. 70: 215-20. PMID 12732415 DOI: 10.1016/S0376-8716(03)00006-1 |
0.346 |
|
| 2003 |
Boysen G, Kenney PM, Upadhyaya P, Wang M, Hecht SS. Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis. 24: 517-25. PMID 12663513 DOI: 10.1093/Carcin/24.3.517 |
0.357 |
|
| 2003 |
Upadhyaya P, Sturla SJ, Tretyakova N, Ziegel R, Villalta PW, Wang M, Hecht SS. Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chemical Research in Toxicology. 16: 180-90. PMID 12588189 DOI: 10.1021/Tx0256376 |
0.574 |
|
| 2003 |
Cheng G, Shi Y, Sturla SJ, Jalas JR, McIntee EJ, Villalta PW, Wang M, Hecht SS. Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chemical Research in Toxicology. 16: 145-52. PMID 12588185 DOI: 10.1021/Tx025614R |
0.563 |
|
| 2003 |
Wong HL, Murphy SE, Wang M, Hecht SS. Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3. Carcinogenesis. 24: 291-300. PMID 12584180 DOI: 10.1093/Carcin/24.2.291 |
0.607 |
|
| 2003 |
Boysen G, Hecht SS. Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutation Research. 543: 17-30. PMID 12510015 DOI: 10.1016/S1383-5742(02)00068-6 |
0.364 |
|
| 2002 |
Carmella SG, Chen M, Villalta PW, Gurney JG, Hatsukami DK, Hecht SS. Ethylation and methylation of hemoglobin in smokers and non-smokers. Carcinogenesis. 23: 1903-10. PMID 12419839 DOI: 10.1093/Carcin/23.11.1903 |
0.393 |
|
| 2002 |
Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene. 21: 7435-51. PMID 12379884 DOI: 10.1038/Sj.Onc.1205803 |
0.381 |
|
| 2002 |
Hecht SS, Kenney PM, Wang M, Upadhyaya P. Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. Cancer Letters. 187: 87-94. PMID 12359355 DOI: 10.1016/S0304-3835(02)00410-X |
0.356 |
|
| 2002 |
Upadhyaya P, Zimmerman CL, Hecht SS. Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1115-22. PMID 12228188 DOI: 10.1124/Dmd.30.10.1115 |
0.408 |
|
| 2002 |
Hecht SS, Upadhyaya P, Wang M, Bliss RL, McIntee EJ, Kenney PM. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis. 23: 1455-61. PMID 12189187 DOI: 10.1093/Carcin/23.9.1455 |
0.35 |
|
| 2002 |
Sticha KR, Kenney PM, Boysen G, Liang H, Su X, Wang M, Upadhyaya P, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis. 23: 1433-9. PMID 12189184 DOI: 10.1093/Carcin/23.9.1433 |
0.395 |
|
| 2002 |
Hecht SS. Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention Lancet Oncology. 3: 461-469. PMID 12147432 DOI: 10.1016/S1470-2045(02)00815-X |
0.433 |
|
| 2002 |
Hecht SS. Human urinary carcinogen metabolites: Biomarkers for investigating tobacco and cancer Carcinogenesis. 23: 907-922. PMID 12082012 DOI: 10.1093/Carcin/23.6.907 |
0.443 |
|
| 2002 |
Stepanov I, Carmella SG, Hecht SS, Duca G. Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco. Journal of Agricultural and Food Chemistry. 50: 2793-7. PMID 11982401 DOI: 10.1021/Jf011552J |
0.413 |
|
| 2002 |
Carmella SG, Le Ka KA, Upadhyaya P, Hecht SS. Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. Chemical Research in Toxicology. 15: 545-50. PMID 11952341 DOI: 10.1021/Tx015584C |
0.408 |
|
| 2002 |
Hecht SS. Tobacco smoke carcinogens and breast cancer Environmental and Molecular Mutagenesis. 39: 119-126. PMID 11921179 DOI: 10.1002/Em.10071 |
0.394 |
|
| 2002 |
Hecht SS, Carmella SG, Ye M, Le KA, Jensen JA, Zimmerman CL, Hatsukami DK. Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use. Cancer Research. 62: 129-34. PMID 11782369 |
0.311 |
|
| 2002 |
Hecht SS, McIntee EJ, Cheng G, Shi Y, Villalta PW, Wang M. New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde. Advances in Experimental Medicine and Biology. 500: 63-71. PMID 11765008 DOI: 10.1007/978-1-4615-0667-6_7 |
0.433 |
|
| 2002 |
Wu Z, Upadhyaya P, Carmella SG, Hecht SS, Zimmerman CL. Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution. Carcinogenesis. 23: 171-9. PMID 11756238 DOI: 10.1093/Carcin/23.1.171 |
0.386 |
|
| 2001 |
Wang M, McIntee EJ, Shi Y, Cheng G, Upadhyaya P, Villalta PW, Hecht SS. Reactions of alpha-acetoxy-N-nitrosopyrrolidine with deoxyguanosine and DNA. Chemical Research in Toxicology. 14: 1435-45. PMID 11599936 DOI: 10.1021/Tx010097I |
0.317 |
|
| 2001 |
Hecht SS, McIntee EJ, Wang M. New DNA adducts of crotonaldehyde and acetaldehyde. Toxicology. 166: 31-6. PMID 11518608 DOI: 10.1016/S0300-483X(01)00436-X |
0.376 |
|
| 2001 |
Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA. Chemical Research in Toxicology. 14: 1025-32. PMID 11511176 DOI: 10.1021/Tx0100385 |
0.336 |
|
| 2001 |
Upadhyaya P, McIntee EJ, Hecht SS. Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines Chemical Research in Toxicology. 14: 555-561. PMID 11368554 DOI: 10.1021/Tx000262E |
0.355 |
|
| 2001 |
Hecht SS, Kenney PMJ, Wang M, Upadhyaya P. Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Cancer Letters. 167: 1-6. PMID 11323092 DOI: 10.1016/S0304-3835(01)00454-2 |
0.301 |
|
| 2001 |
Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. A Schiff base is a major DNA adduct of crotonaldehyde. Chemical Research in Toxicology. 14: 423-30. PMID 11304131 DOI: 10.1021/Tx000234W |
0.353 |
|
| 2001 |
Anderson KE, Carmella SG, Ye M, Bliss RL, Le C, Murphy L, Hecht SS. Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke. Journal of the National Cancer Institute. 93: 378-81. PMID 11238699 DOI: 10.1093/Jnci/93.5.378 |
0.394 |
|
| 2001 |
Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. Identification of DNA adducts of acetaldehyde. Chemical Research in Toxicology. 13: 1149-57. PMID 11087437 DOI: 10.1021/Tx000118T |
0.357 |
|
| 2001 |
Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. Identification of paraldol-deoxyguanosine adducts in DNA reacted with crotonaldehyde. Chemical Research in Toxicology. 13: 1065-74. PMID 11080056 DOI: 10.1021/Tx000095I |
0.359 |
|
| 2000 |
Hecht SS. Inhibition of carcinogenesis by isothiocyanates Drug Metabolism Reviews. 32: 395-411. PMID 11139137 DOI: 10.1081/Dmr-100102342 |
0.336 |
|
| 2000 |
Hecht SS, Hoffmann D. Re: Cigar smoking in men and risk of death from tobacco-related cancers. Journal of the National Cancer Institute. 92: 2040. PMID 11121469 DOI: 10.1093/Jnci/92.24.2040 |
0.536 |
|
| 2000 |
Hecht SS, Hochalter BJ, Villalta PW, Murphy SE. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor Proceedings of the National Academy of Sciences of the United States of America. 97: 12493-12497. PMID 11050152 DOI: 10.1073/Pnas.220207697 |
0.368 |
|
| 2000 |
Sticha KR, Staretz ME, Wang M, Liang H, Kenney PM, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse. Carcinogenesis. 21: 1711-9. PMID 10964103 DOI: 10.1093/Carcin/21.9.1711 |
0.325 |
|
| 2000 |
Hecht SS. Metabolically activated carcinogens and mutations in the p53 tumor suppressor gene in lung cancer Journal of the National Cancer Institute. 92: 782-783. PMID 10814664 DOI: 10.1093/Jnci/92.10.782 |
0.309 |
|
| 2000 |
Simpson CD, Wu MT, Christiani DC, Santella RM, Carmella SG, Hecht SS. Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry. Chemical Research in Toxicology. 13: 271-80. PMID 10775327 DOI: 10.1021/Tx990202C |
0.312 |
|
| 2000 |
Hecht SS, Kenney PM, Wang M, Trushin N, Upadhyaya P. Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Letters. 150: 49-56. PMID 10755386 DOI: 10.1016/S0304-3835(99)00373-0 |
0.337 |
|
| 2000 |
Carmella SG, McIntee EJ, Chen M, Hecht SS. Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco. Carcinogenesis. 21: 839-43. PMID 10753225 DOI: 10.1093/Carcin/21.4.839 |
0.389 |
|
| 2000 |
Milunsky A, Carmella SG, Ye M, Hecht SS. A tobacco-specific carcinogen in the fetus. Prenatal Diagnosis. 20: 307-10. PMID 10740203 DOI: 10.1002/(Sici)1097-0223(200004)20:4<307::Aid-Pd797>3.0.Co;2-M |
0.391 |
|
| 2000 |
McIntee EJ, Hecht SS. Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats. Chemical Research in Toxicology. 13: 192-9. PMID 10725116 DOI: 10.1021/Tx990171L |
0.355 |
|
| 2000 |
Upadhyaya P, Carmella SG, Guengerich F, Hecht SS. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues Carcinogenesis. 21: 1233-1238. DOI: 10.1093/Carcin/21.6.1233 |
0.349 |
|
| 1999 |
Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse. Carcinogenesis. 20: 1577-82. PMID 10426810 DOI: 10.1093/Carcin/20.8.1577 |
0.361 |
|
| 1999 |
Hecht SS. Tobacco smoke carcinogens and lung cancer Journal of the National Cancer Institute. 91: 1194-1210. PMID 10413421 DOI: 10.1093/Jnci/91.14.1194 |
0.432 |
|
| 1999 |
Hecht SS, Kenney PM, Wang M, Trushin N, Agarwal S, Rao AV, Upadhyaya P. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Letters. 137: 123-30. PMID 10374832 DOI: 10.1016/S0304-3835(98)00326-7 |
0.34 |
|
| 1999 |
Lin JM, Desai D, Chung L, Hecht SS, Amin S. Synthesis of anti-7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydro-11-methylbenzo[a]pyrene and its reaction with DNA. Chemical Research in Toxicology. 12: 341-6. PMID 10207123 DOI: 10.1021/Tx980178N |
0.335 |
|
| 1999 |
Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism Journal of Nutrition. 129. PMID 10082787 DOI: 10.1093/Jn/129.3.768S |
0.392 |
|
| 1999 |
Lackmann GM, Salzberger U, Töllner U, Chen M, Carmella SG, Hecht SS. Metabolites of a tobacco-specific carcinogen in urine from newborns. Journal of the National Cancer Institute. 91: 459-65. PMID 10070946 DOI: 10.1093/Jnci/91.5.459 |
0.394 |
|
| 1999 |
Hecht SS. DNA adduct formation from tobacco-specific N-nitrosamines Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 424: 127-142. PMID 10064856 DOI: 10.1016/S0027-5107(99)00014-7 |
0.461 |
|
| 1999 |
Trushin N, Hecht SS. Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats. Chemical Research in Toxicology. 12: 164-71. PMID 10027794 DOI: 10.1021/Tx980213Q |
0.381 |
|
| 1999 |
Melikian AA, Malpure S, John A, Meng M, Schoket B, Mayer G, Vincze I, Kolozsi-ringelhann A, Hecht SS. Determination of Hemoglobin and Serum Albumin Adducts of Benzo[a]Pyrene by Gas Chromatography-Mass Spectrometry in Humans and Their Relation to Exposure and to other Biological Markers Polycyclic Aromatic Compounds. 17: 125-134. DOI: 10.1080/10406639908020608 |
0.303 |
|
| 1999 |
Lin J, Desai D, Chung L, Hecht SS, Amin S. Syntheses ofanti-7,8,9,10-Tetrahydro-11-, and 12-Methylbenzo[A]Pyrene-7,8-DIOL-9, 10-Epoxides: Identification and Comparison of DNA Adduct Formation with Calf-Thymus DNAin vitro Polycyclic Aromatic Compounds. 17: 63-72. DOI: 10.1080/10406639908020602 |
0.349 |
|
| 1999 |
Lackmann GM, Salzberger U, Chen M, Carmella SG, Töllner U, Hecht SS. Tobacco-specific transplacental carcinogens, nicotine, and cotinine in the urine of newborns of smoking mothers Monatsschrift Fur Kinderheilkunde. 147: 333-338. DOI: 10.1007/S001120050431 |
0.402 |
|
| 1998 |
Stoner GD, Adams C, Kresty LA, Amin SG, Desai D, Hecht SS, Murphy SE, Morsc MA. Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate Carcinogenesis. 19: 2139-2143. PMID 9886569 DOI: 10.1093/Carcin/19.12.2139 |
0.319 |
|
| 1998 |
Wang M, Upadhyaya P, Dinh TT, Bonilla LE, Hecht SS. Lactols in hydrolysates of DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or crotonaldehyde. Chemical Research in Toxicology. 11: 1567-73. PMID 9860502 DOI: 10.1021/tx980165 |
0.323 |
|
| 1998 |
Hecht SS, Hoffmann D. N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 7: 165-6. PMID 9818780 |
0.415 |
|
| 1998 |
Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N- nitrosamines Chemical Research in Toxicology. 11: 559-603. PMID 9625726 DOI: 10.1021/Tx980005Y |
0.373 |
|
| 1998 |
Hecht SS, Hoffman D. Erratum: N-nitroso compounds and man: Sources of exposure, endogenous formation and occurrence in body fluids (European Journal of Cancer Prevention (June 1998) 7 (244-246)) European Journal of Cancer Prevention. 7. DOI: 10.1097/00008469-199806000-00013 |
0.309 |
|
| 1997 |
Hecht SS. Tobacco and cancer: Approaches using carcinogen biomarkers and chemoprevention Annals of the New York Academy of Sciences. 833: 91-111. PMID 9616743 DOI: 10.1111/J.1749-6632.1997.Tb48596.X |
0.411 |
|
| 1997 |
Cinciripini PM, Hecht SS, Henningfield JE, Manley MW, Kramer BS. Tobacco addiction: Implications for treatment and cancer prevention Journal of the National Cancer Institute. 89: 1852-1867. PMID 9414173 DOI: 10.1093/Jnci/89.24.1852 |
0.348 |
|
| 1997 |
Hecht SS. Approaches to cancer prevention based on an understanding of N- nitrosamine carcinogenesis Proceedings of the Society For Experimental Biology and Medicine. 216: 181-191. PMID 9349687 DOI: 10.3181/00379727-216-44168 |
0.385 |
|
| 1997 |
Staretz ME, Koenig LA, Hecht SS. Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. Carcinogenesis. 18: 1715-22. PMID 9328166 DOI: 10.1093/Carcin/18.9.1715 |
0.347 |
|
| 1997 |
Chen LJ, Hecht SS, Peterson LA. Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chemical Research in Toxicology. 10: 866-74. PMID 9282835 DOI: 10.1021/Tx9700174 |
0.32 |
|
| 1997 |
Hecht SS. Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke Environmental Health Perspectives. 105: 955-963. PMID 9255587 DOI: 10.1289/Ehp.97105S4955 |
0.406 |
|
| 1997 |
Wang M, Hecht SS. A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chemical Research in Toxicology. 10: 772-8. PMID 9250411 DOI: 10.1021/Tx960193X |
0.378 |
|
| 1997 |
Wang L, Spratt TE, Liu XK, Hecht SS, Pegg AE, Peterson LA. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 10: 562-7. PMID 9168254 DOI: 10.1021/Tx9602067 |
0.306 |
|
| 1997 |
Carmella SG, Borukhova A, Desai D, Hecht SS. Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis. 18: 587-92. PMID 9067560 DOI: 10.1093/Carcin/18.3.587 |
0.387 |
|
| 1997 |
Melikian AA, Sun P, Coleman S, Amin S, Hecht SS. Detection of DNA and globin adducts of polynuclear aromatic hydrocarbon diol epoxides by gas chromatography-mass spectrometry and -3H-CH3I postlabeling of released tetraols. Chemical Research in Toxicology. 9: 508-16. PMID 8839056 DOI: 10.1021/Tx950165Z |
0.323 |
|
| 1996 |
Hecht SS. Chemoprevention of lung cancer by isothiocyanates Advances in Experimental Medicine and Biology. 401: 1-11. PMID 8886122 DOI: 10.1007/978-1-4613-0399-2_1 |
0.416 |
|
| 1996 |
Liu Z, Young-Sciame R, Hecht SS. Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal. Chemical Research in Toxicology. 9: 774-80. PMID 8831822 DOI: 10.1021/Tx950206R |
0.342 |
|
| 1996 |
Hecht SS, Trushin N, Rigotty J, Carmella SG, Borukhova A, Akerkar S, Desai D, Amin S, Rivenson A. Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats. Carcinogenesis. 17: 2061-7. PMID 8824535 DOI: 10.1093/Carcin/17.9.2061 |
0.339 |
|
| 1996 |
Hecht SS. Carcinogen-derived biomarkers and lung cancer Preventive Medicine. 25: 7-9. PMID 8778771 DOI: 10.1006/Pmed.1996.0004 |
0.384 |
|
| 1996 |
Hoffmann D, Rivenson A, Hecht SS. The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung. Critical Reviews in Toxicology. 26: 199-211. PMID 8688161 DOI: 10.3109/10408449609017931 |
0.569 |
|
| 1996 |
Hecht SS. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen Critical Reviews in Toxicology. 26: 163-181. PMID 8688159 DOI: 10.3109/10408449609017929 |
0.416 |
|
| 1996 |
Amin S, Desai D, Hecht SS, Hoffmann D. Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays. Critical Reviews in Toxicology. 26: 139-47. PMID 8688157 DOI: 10.3109/10408449609017927 |
0.582 |
|
| 1996 |
Melikian AA, Sun P, Coleman S, Murphy SE, Amin S, Hecht SS. Detection of Polynuclear Aromatic Hydrocarbon Diol Epoxide-Derived DNA and Globin Adducts in Humans by Gas Chromatography-Mass Spectrometry Polycyclic Aromatic Compounds. 10: 315-322. DOI: 10.1080/10406639608034712 |
0.348 |
|
| 1996 |
Koehl W, Amin S, Yamazaki H, Ueng Y, Tateishi T, Guengerich FP, Hecht SS. Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes Polycyclic Aromatic Compounds. 10: 59-66. DOI: 10.1080/10406639608034680 |
0.357 |
|
| 1995 |
Chen LJ, Hecht SS, Peterson LA. Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan. Chemical Research in Toxicology. 8: 903-6. PMID 8555403 DOI: 10.1021/Tx00049A001 |
0.31 |
|
| 1995 |
Hecht SS. Chemoprevention by isothiocyanates Journal of Cellular Biochemistry. 58: 195-209. PMID 8538199 DOI: 10.1002/Jcb.240590825 |
0.411 |
|
| 1995 |
Hecht SS, Isaacs S, Trushin N. Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. Carcinogenesis. 15: 2721-5. PMID 8001227 DOI: 10.1093/Carcin/15.12.2721 |
0.367 |
|
| 1995 |
el-Bayoumy K, Johnson B, Roy AK, Upadhyaya P, Partian S, Hecht SS. Development of methods to monitor exposure to 1-nitropyrene. Environmental Health Perspectives. 31-7. PMID 7889855 DOI: 10.1289/Ehp.94102S631 |
0.339 |
|
| 1995 |
Hecht SS, Amin S, Lin JM, Rivenson A, Kurtzke C, el-Bayoumy K. Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant. Carcinogenesis. 16: 1433-5. PMID 7788865 DOI: 10.1093/Carcin/16.6.1433 |
0.309 |
|
| 1995 |
Wang M, Young-Sciame R, Chung FL, Hecht SS. Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA. Chemical Research in Toxicology. 8: 617-24. PMID 7548743 DOI: 10.1021/Tx00046A017 |
0.31 |
|
| 1994 |
el-Bayoumy K, Johnson B, Partian S, Upadhyaya P, Hecht SS. In vivo binding of 1-nitropyrene to albumin in the rat. Carcinogenesis. 15: 119-23. PMID 8293536 DOI: 10.1093/Carcin/15.1.119 |
0.346 |
|
| 1994 |
Balasta L, Xu R, Geacintov NE, Swenberg CE, Amin S, Hecht SS. Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities. Chemical Research in Toxicology. 6: 616-24. PMID 8292738 DOI: 10.1021/Tx00035A005 |
0.31 |
|
| 1994 |
Lin JM, Amin S, Trushin N, Hecht SS. Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. Cancer Letters. 74: 151-9. PMID 8174099 DOI: 10.1016/0304-3835(93)90237-4 |
0.321 |
|
| 1994 |
Desai D, Kagan SS, Amin S, Carmella SG, Hecht SS. Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents. Chemical Research in Toxicology. 6: 794-9. PMID 8117917 DOI: 10.1021/Tx00036A007 |
0.371 |
|
| 1994 |
Hecht SS. Metabolic activation and detoxification of tobacco-specific nitrosamines-a model for cancer prevention strategies Drug Metabolism Reviews. 26: 373-390. PMID 8082576 DOI: 10.3109/03602539409029803 |
0.34 |
|
| 1994 |
Hecht SS. Environmental tobacco smoke and lung cancer: The emerging role of carcinogen biomarkers and molecular epidemiology Journal of the National Cancer Institute. 86: 1369-1370. PMID 8072024 DOI: 10.1093/Jnci/86.18.1369 |
0.403 |
|
| 1994 |
Hecht SS, Carmella SG, Murphy SE. Tobacco-specific nitrosamine-hemoglobin adducts Methods in Enzymology. 231: 657-667. PMID 8041285 DOI: 10.1016/0076-6879(94)31046-7 |
0.431 |
|
| 1994 |
Peterson LA, Ng DK, Stearns RA, Hecht SS. Formation of NADP(H) analogs of tobacco-specific nitrosamines in rat liver and pancreatic microsomes. Chemical Research in Toxicology. 7: 599-608. PMID 7841337 DOI: 10.1021/Tx00041A003 |
0.372 |
|
| 1993 |
el-Bayoumy K, Upadhyaya P, Desai DH, Amin S, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Carcinogenesis. 14: 1111-3. PMID 8508496 DOI: 10.1093/Carcin/14.6.1111 |
0.308 |
|
| 1993 |
Hecht SS, Trushin N, Reid-Quinn CA, Burak ES, Jones AB, Southers JL, Gombar CT, Carmella SG, Anderson LM, Rice JM. Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis. 14: 229-36. PMID 8435864 DOI: 10.1093/Carcin/14.2.229 |
0.375 |
|
| 1993 |
Hecht SS, Carmella SG, Murphy SE, Akerkar S, Brunnemann KD, Hoffmann D. A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke. The New England Journal of Medicine. 329: 1543-6. PMID 8413477 DOI: 10.1056/Nejm199311183292105 |
0.584 |
|
| 1993 |
Hecht SS, Carmella SG, Murphy SE, Foiles PG, Chung FL. Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer Journal of Cellular Biochemistry. Supplement. 17: 27-35. PMID 8412204 DOI: 10.1002/Jcb.240531005 |
0.439 |
|
| 1993 |
Swenson DH, el-Bayoumy K, Shuie GH, Hecht SS, Fiala E, Kadlubar FF, Freeman JP. Synthesis of N-(purin-8-yl)arylamines. Chemical Research in Toxicology. 6: 480-5. PMID 8374045 DOI: 10.1021/Tx00034A014 |
0.337 |
|
| 1993 |
Alworth WL, Young-Sciame R, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450. Carcinogenesis. 14: 1711-3. PMID 8353857 DOI: 10.1093/Carcin/14.8.1711 |
0.322 |
|
| 1993 |
Hecht SS, Carmella SG, Foiles PG, Murphy SE, Peterson LA. Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans. Environmental Health Perspectives. 99: 57-63. PMID 8319660 DOI: 10.1289/Ehp.939957 |
0.437 |
|
| 1993 |
Carmella SG, Kagan SS, Hecht SS. Evidence that a hemoglobin adduct used for dosimetry of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a carboxylic ester. Environmental Health Perspectives. 99: 203-5. PMID 8319624 DOI: 10.1289/Ehp.9399203 |
0.356 |
|
| 1993 |
Ronai ZA, Gradia S, Peterson LA, Hecht SS. G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis. 14: 2419-22. PMID 7902220 DOI: 10.1093/Carcin/14.11.2419 |
0.327 |
|
| 1993 |
el-Bayoumy K, Desai D, Upadhyaya P, Amin S, Hecht SS. Comparative tumorigenicity of nitrochrysene isomers in newborn mice. Carcinogenesis. 13: 2271-5. PMID 1473233 DOI: 10.1093/Carcin/13.12.2271 |
0.3 |
|
| 1993 |
Lin J, Amin S, Murphy SE, Solomon JJ, Hecht SS. Synthesis of [3,3-D2]4-hydroxy-1-(3-pyridyl)-1-butanone, an internal standard for analysis of tobacco-specific nitrosamine hemoglobin and DNA adducts Journal of Labelled Compounds and Radiopharmaceuticals. 33: 285-292. DOI: 10.1002/Jlcr.2580330406 |
0.328 |
|
| 1992 |
Amin S, Balanikas G, Huie K, Hecht SS. Synthesis and tumor-initiating activities of dimethylchrysenes. Chemical Research in Toxicology. 1: 349-55. PMID 2979752 DOI: 10.1021/Tx00006A005 |
0.322 |
|
| 1992 |
el-Bayoumy K, Shiue GH, Hecht SS. Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice. Chemical Research in Toxicology. 1: 243-7. PMID 2979739 DOI: 10.1021/Tx00004A010 |
0.342 |
|
| 1992 |
Wang MY, Chung FL, Hecht SS. Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine. Chemical Research in Toxicology. 1: 28-31. PMID 2979707 DOI: 10.1021/Tx00001A005 |
0.338 |
|
| 1992 |
Wang M, Chung FL, Hecht SS. Formation of acyclic and cyclic guanine adducts in DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. Chemical Research in Toxicology. 2: 423-8. PMID 2519732 DOI: 10.1021/Tx00012A011 |
0.353 |
|
| 1992 |
Spratt TE, Trushin N, Lin D, Hecht SS. Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. Chemical Research in Toxicology. 2: 169-73. PMID 2519721 DOI: 10.1021/Tx00009A008 |
0.387 |
|
| 1992 |
Misra B, Amin S, Hecht SS. Metabolism and DNA binding of 5,6-dimethylchrysene in mouse skin. Chemical Research in Toxicology. 5: 242-7. PMID 1643254 DOI: 10.1021/Tx00026A015 |
0.326 |
|
| 1992 |
Carmella SG, Kagan SS, Hecht SS. Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester. Chemical Research in Toxicology. 5: 76-80. PMID 1581541 DOI: 10.1021/Tx00025A013 |
0.361 |
|
| 1992 |
Hecht SS, Young-Sciame R, Chung FL. Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct. Chemical Research in Toxicology. 5: 706-12. PMID 1446012 DOI: 10.1021/Tx00029A018 |
0.343 |
|
| 1992 |
Lin JM, Desai DH, Morse MA, Amin S, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol Chemical Research in Toxicology. 5: 674-679. PMID 1446008 DOI: 10.1021/Tx00029A013 |
0.362 |
|
| 1992 |
Wang M, Chung FL, Hecht SS. Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine. Carcinogenesis. 13: 1909-11. PMID 1423852 DOI: 10.1093/Carcin/13.10.1909 |
0.343 |
|
| 1991 |
Hoffmann D, Rivenson A, Chung FL, Hecht SS. Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. Critical Reviews in Toxicology. 21: 305-11. PMID 2069715 DOI: 10.3109/10408449109017917 |
0.617 |
|
| 1991 |
Rivenson A, Hecht SS, Hoffmann D. Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs. Critical Reviews in Toxicology. 21: 255-64. PMID 2069711 DOI: 10.3109/10408449109017913 |
0.481 |
|
| 1991 |
Hecht SS, Morse MA, Eklind KI, Chung FL. A/j mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates Experimental Lung Research. 17: 501-511. PMID 2050046 DOI: 10.3109/01902149109064435 |
0.407 |
|
| 1991 |
Amin S, Misra B, Braley J, Hecht SS. Comparative tumorigenicity in newborn mice of chrysene- and 5-alkylchrysene-1,2-diol-3,4-epoxides Cancer Letters. 58: 115-118. PMID 2049777 DOI: 10.1016/0304-3835(91)90032-D |
0.32 |
|
| 1991 |
Doerr-O'Rourke K, Trushin N, Hecht SS, Stoner GD. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue. Carcinogenesis. 12: 1029-34. PMID 2044181 DOI: 10.1093/Carcin/12.6.1029 |
0.365 |
|
| 1991 |
Peterson LA, Mathew R, B1P6Murphy SE, Trushin N, Hecht SS. In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 12: 2069-72. PMID 1934291 DOI: 10.1093/Carcin/12.11.2069 |
0.361 |
|
| 1991 |
Foiles PG, Akerkar SA, Carmella SG, Kagan M, Stoner GD, Resau JH, Hecht SS. Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers. Chemical Research in Toxicology. 4: 364-8. PMID 1912321 DOI: 10.1021/Tx00021A017 |
0.442 |
|
| 1991 |
Melikian AA, Prahalad KA, Amin S, Hecht SS. Comparative DNA binding of polynuclear aromatic hydrocarbons and their dihydrodiol and bay region diolepoxide metabolites in newborn mouse lung and liver. Carcinogenesis. 12: 1665-70. PMID 1893526 DOI: 10.1093/Carcin/12.9.1665 |
0.356 |
|
| 1991 |
Hecht SS, Hoffmann D. N-nitroso compounds and tobacco-induced cancers in man. Iarc Scientific Publications. 54-61. PMID 1855913 |
0.501 |
|
| 1991 |
Anderson LM, Hecht SS, Kovatch RM, Amin S, Hoffmann D, Rice JM. Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice. Cancer Letters. 58: 177-81. PMID 1855194 DOI: 10.1016/0304-3835(91)90097-2 |
0.52 |
|
| 1990 |
Peterson LA, Carmella SG, Hecht SS. Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 11: 1329-33. PMID 2387018 DOI: 10.1093/Carcin/11.8.1329 |
0.316 |
|
| 1990 |
Murphy SE, Palomino A, Hecht SS, Hoffmann D. Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Research. 50: 5446-52. PMID 2386949 |
0.458 |
|
| 1990 |
Hecht SS, Jordan KG, Choi CI, Trushin N. Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice. Carcinogenesis. 11: 1017-20. PMID 2347060 DOI: 10.1093/Carcin/11.6.1017 |
0.313 |
|
| 1990 |
Amin S, Hecht SS, Di Raddo P, Harvey RG. Comparative tumor initiating activities of cyclopentano and methyl derivatives of 5-methylchrysene and chrysene. Cancer Letters. 51: 17-20. PMID 2337893 DOI: 10.1016/0304-3835(90)90225-M |
0.304 |
|
| 1990 |
Morse MA, Hecht SS, Chung FL. Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate Basic Life Sciences. 52: 345-350. PMID 2327941 DOI: 10.1007/978-1-4615-9561-8_30 |
0.392 |
|
| 1990 |
Spratt TE, Peterson LA, Confer WL, Hecht SS. Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles. Chemical Research in Toxicology. 3: 350-6. PMID 2133084 DOI: 10.1021/Tx00016A013 |
0.362 |
|
| 1989 |
Amin S, Huie K, Balanikas G, Hecht SS. Synthesis and mutagenicity of 5-alkyl-substituted chrysene-1,2-diol-3,4-epoxides. Carcinogenesis. 9: 2305-8. PMID 3191576 DOI: 10.1093/Carcin/9.12.2305 |
0.315 |
|
| 1989 |
el-Bayoumy K, Shiue GH, Hecht SS. Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice. Carcinogenesis. 10: 369-72. PMID 2912588 DOI: 10.1093/Carcin/10.2.369 |
0.331 |
|
| 1989 |
Roy AK, el-Bayoumy K, Hecht SS. 32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats. Carcinogenesis. 10: 195-8. PMID 2910523 DOI: 10.1093/Carcin/10.1.195 |
0.345 |
|
| 1989 |
Morse MA, Eklind KI, Amin SG, Hecht SS, Chung FL. Effects of alkyl chain length on the inhibition of nnk-induced lung neoplasia in a/j mice by arylalkyl isothiocyanates Carcinogenesis. 10: 1757-1759. PMID 2766468 DOI: 10.1093/Carcin/10.9.1757 |
0.312 |
|
| 1989 |
Hecht SS, Lijinsky W, Kovatch RM, Chung FL, Saavedra JE. Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats. Carcinogenesis. 10: 1475-7. PMID 2752522 DOI: 10.1093/Carcin/10.8.1475 |
0.333 |
|
| 1989 |
Melikian AA, Hecht SS, Hoffmann D. Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues. Progress in Clinical and Biological Research. 298: 331-45. PMID 2748687 |
0.522 |
|
| 1989 |
Chung FL, Young R, Hecht SS. Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde. Carcinogenesis. 10: 1291-7. PMID 2736720 DOI: 10.1093/Carcin/10.7.1291 |
0.355 |
|
| 1989 |
Anderson LM, Hecht SS, Dixon DE, Dove LF, Kovatch RM, Amin S, Hoffmann D, Rice JM. Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. Cancer Research. 49: 3770-5. PMID 2736518 |
0.422 |
|
| 1989 |
Hecht SS, Hoffmann D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surveys. 8: 273-94. PMID 2696581 |
0.455 |
|
| 1989 |
Amin S, Misra B, Desai D, Huie K, Hecht SS. Chromatographic conditions for separation of 32P-labeled phosphates of major polynuclear aromatic hydrocarbon--deoxyribonucleoside adducts. Carcinogenesis. 10: 1971-4. PMID 2676227 DOI: 10.1093/Carcin/10.10.1971 |
0.32 |
|
| 1989 |
el-Bayoumy K, Shiue GH, Amin S, Hecht SS. The effects of bay-region methyl substitution on 6-nitrochrysene mutagenicity in Salmonella typhimurium and tumorigenicity in newborn mice. Carcinogenesis. 10: 1685-9. PMID 2670305 DOI: 10.1093/Carcin/10.9.1685 |
0.327 |
|
| 1989 |
el-Bayoumy K, Delclos KB, Heflich RH, Walker R, Shiue GH, Hecht SS. Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. Mutagenesis. 4: 235-40. PMID 2659942 DOI: 10.1093/Mutage/4.3.235 |
0.355 |
|
| 1989 |
Belinsky SA, White CM, Trushin N, Hecht SS. Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the fischer rat Carcinogenesis. 10: 2269-2274. PMID 2591016 DOI: 10.1093/Carcin/10.12.2269 |
0.35 |
|
| 1989 |
Melikian AA, Jordan KG, Braley J, Rigotty J, Meschter CL, Hecht SS, Hoffmann D. Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes. Carcinogenesis. 10: 1897-900. PMID 2507190 DOI: 10.1093/Carcin/10.10.1897 |
0.487 |
|
| 1989 |
Foiles PG, Miglietta LM, Quart AM, Quart E, Kabat GC, Hecht SS. Evaluation of 32P-postlabeling analysis of DNA from exfoliated oral mucosa cells as a means of monitoring exposure of the oral cavity to genotoxic agents. Carcinogenesis. 10: 1429-34. PMID 2502322 DOI: 10.1093/Carcin/10.8.1429 |
0.357 |
|
| 1989 |
Melikian AA, Bagheri K, Hecht SS, Hoffmann D. Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice. Chemico-Biological Interactions. 69: 245-57. PMID 2495193 DOI: 10.1016/0009-2797(89)90082-3 |
0.503 |
|
| 1988 |
Hecht SS, Trushin N. DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. Carcinogenesis. 9: 1665-8. PMID 3409470 DOI: 10.1093/Carcin/9.9.1665 |
0.373 |
|
| 1988 |
Roy AK, el-Bayoumy K, Hecht SS. Metabolism of K-region derivatives of 1-nitropyrene by rat liver in vitro. Carcinogenesis. 9: 255-8. PMID 3338108 DOI: 10.1093/Carcin/9.2.255 |
0.313 |
|
| 1988 |
Hecht SS, Spratt TE, Trushin N. Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. Carcinogenesis. 9: 161-5. PMID 3335041 DOI: 10.1093/Carcin/9.1.161 |
0.35 |
|
| 1988 |
Hecht SS, Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis. 9: 875-84. PMID 3286030 DOI: 10.1093/Carcin/9.6.875 |
0.598 |
|
| 1988 |
Hecht SS, Carmella SG, Trushin N, Spratt TE, Foiles PG, Hoffmann D. Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. Iarc Scientific Publications. 121-8. PMID 3198194 |
0.555 |
|
| 1988 |
Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Research. 48: 6912-7. PMID 3180100 |
0.493 |
|
| 1988 |
Morse MA, Wang CX, Amin SG, Hecht SS, Chung FL. Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats Carcinogenesis. 9: 1891-1895. PMID 3168166 DOI: 10.1093/Carcin/9.10.1891 |
0.36 |
|
| 1988 |
Delclos KB, el-Bayoumy K, Hecht SS, Walker RP, Kadlubar FF. Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite. Carcinogenesis. 9: 1875-84. PMID 3168165 DOI: 10.1093/Carcin/9.10.1875 |
0.343 |
|
| 1988 |
Wiley JC, Chien DHT, Nungesser NA, Lin D, Hecht SS. Synthesis of 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, 4- (carbethoxynitrosamino)-1- (3-pyridyl)-1-butanone, and N′ -nitrosonornicotine labelled with tritium in the pyridine ring Journal of Labelled Compounds and Radiopharmaceuticals. 25: 707-716. DOI: 10.1002/Jlcr.2580250703 |
0.301 |
|
| 1987 |
Hecht SS, Lin D, Castonguay A, Rivenson A. Effects of α-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in f344 rats Carcinogenesis. 8: 291-294. PMID 3802414 DOI: 10.1093/Carcin/8.2.291 |
0.32 |
|
| 1987 |
Brunnemann KD, Rivenson A, Adams JD, Hecht SS, Hoffmann D. A study of snuff carcinogenesis. Iarc Scientific Publications. 456-9. PMID 3679421 |
0.469 |
|
| 1987 |
Domellöf L, Andersson M, Tjälve H, Veals S, Trushin N, Hecht SS. Distribution and metabolism of N'-nitrosonornicotine in the miniature pig. Carcinogenesis. 8: 1741-7. PMID 3664969 DOI: 10.1093/Carcin/8.11.1741 |
0.303 |
|
| 1987 |
Geddie JE, Amin S, Huie K, Hecht SS. Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis. Carcinogenesis. 8: 1579-84. PMID 3664950 DOI: 10.1093/Carcin/8.11.1579 |
0.339 |
|
| 1987 |
Shiue GH, el-Bayoumy K, Hecht SS. Comparative metabolism and DNA binding of 6-nitro-5-methylchrysene and 5-methylchrysene. Carcinogenesis. 8: 1327-31. PMID 3621469 DOI: 10.1093/Carcin/8.9.1327 |
0.362 |
|
| 1987 |
Abbaspour A, Hecht SS, Hoffmann D. Synthesis of 5'-carboxy-N'-nitrosonornicotine and 5'-[14C]carboxy-N'-nitrosonornicotine The Journal of Organic Chemistry. 52: 3474-3477. DOI: 10.1021/Jo00391A066 |
0.471 |
|
| 1986 |
el-Bayoumy K, Donahue JM, Hecht SS, Hoffmann D. Identification and quantitative determination of aniline and toluidines in human urine. Cancer Research. 46: 6064-7. PMID 3779628 |
0.489 |
|
| 1986 |
Hecht SS, Rivenson A, Braley J, DiBello J, Adams JD, Hoffmann D. Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. Cancer Research. 46: 4162-6. PMID 3731083 |
0.416 |
|
| 1986 |
Hecht SS, Lin D. Comparative mutagenicity of 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal and 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, model compounds for alpha-hydroxylation of N'-nitrosonornicotine. Carcinogenesis. 7: 611-4. PMID 3516432 DOI: 10.1093/Carcin/7.4.611 |
0.338 |
|
| 1986 |
Connolly GN, Winn DM, Hecht SS, Henningfield JE, Walker B, Hoffmann D. The reemergence of smokeless tobacco. The New England Journal of Medicine. 314: 1020-7. PMID 3515184 DOI: 10.1056/Nejm198604173141605 |
0.527 |
|
| 1986 |
Melikian AA, Leszczynska JM, Hecht SS, Hoffmann D. Effects of the co-carcinogen catechol on benzo[a]pyrene metabolism and DNA adduct formation in mouse skin. Carcinogenesis. 7: 9-15. PMID 3510752 DOI: 10.1093/Carcin/7.1.9 |
0.521 |
|
| 1986 |
el-Bayoumy K, Amin S, Hecht SS. Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism. Carcinogenesis. 7: 673-6. PMID 3509952 DOI: 10.1093/Carcin/7.4.673 |
0.32 |
|
| 1986 |
Hecht SS, Lin D, Chuang J, Castonguay A. A study of chemical carcinogenesis. 91. Reactions with deoxyguanosine of 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a model compound for .alpha.-hydroxylation of tobacco-specific nitrosamines Journal of the American Chemical Society. 108: 1292-1295. DOI: 10.1021/Ja00266A027 |
0.31 |
|
| 1985 |
Castonguay A, Foiles PG, Trushin N, Hecht SS. Study of DNA methylation by tobacco-specific N-nitrosamines Environmental Health Perspectives. 197-202. PMID 4085424 DOI: 10.1289/Ehp.8562197 |
0.341 |
|
| 1985 |
Chung FL, Hecht SS. Formation of the cyclic 1,N2-glyoxal-deoxyguanosine adduct upon reaction of N-nitroso-2-hydroxymorpholine with deoxyguanosine. Carcinogenesis. 6: 1671-3. PMID 4053285 DOI: 10.1093/Carcin/6.11.1671 |
0.303 |
|
| 1985 |
Murphy SE, Hecht SS. Dual-label high-performance liquid chromatographic assay for femtomole levels of benzo[a]pyrene metabolites Analytical Biochemistry. 146: 442-447. PMID 4025808 DOI: 10.1016/0003-2697(85)90567-6 |
0.328 |
|
| 1985 |
Carmella SG, Hecht SS. High-performance liquid chromatographic analysis of metabolites of the nicotine-derived nitrosamines, N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Analytical Biochemistry. 145: 239-44. PMID 4014657 DOI: 10.1016/0003-2697(85)90356-2 |
0.325 |
|
| 1985 |
Melikian AA, Hecht SS, Hoffmann D, Pataki J, Harvey RG. Analysis of syn- and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene -deoxyribonucleoside adducts by boronate chromatography. Cancer Letters. 27: 91-7. PMID 4005825 DOI: 10.1016/0304-3835(85)90012-6 |
0.491 |
|
| 1985 |
Chung FL, Wang MY, Hecht SS. Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver. Carcinogenesis. 6: 539-43. PMID 3986960 DOI: 10.1093/Carcin/6.4.539 |
0.36 |
|
| 1985 |
el-Bayoumy K, O'Donnell M, Hecht SS, Hoffmann D. On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke. Carcinogenesis. 6: 505-7. PMID 3986957 DOI: 10.1093/Carcin/6.4.505 |
0.546 |
|
| 1985 |
Melikian AA, Leszczynska JM, Amin S, Hecht SS, Hoffmann D, Pataki J, Harvey RG. Rates of hydrolysis and extents of DNA binding of 5-methylchrysene dihydrodiol epoxides. Cancer Research. 45: 1990-6. PMID 3986755 |
0.427 |
|
| 1985 |
Hoffmann D, Lavoie EJ, Hecht SS. Nicotine: a precursor for carcinogens. Cancer Letters. 26: 67-75. PMID 3971354 DOI: 10.1016/0304-3835(85)90174-0 |
0.583 |
|
| 1985 |
Hoffmann D, Hecht SS. Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Research. 45: 935-44. PMID 3882226 |
0.479 |
|
| 1985 |
Hecht SS, Radok L, Amin S, Huie K, Melikian AA, Hoffmann D, Pataki J, Harvey RG. Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin. Cancer Research. 45: 1449-52. PMID 3838497 |
0.401 |
|
| 1985 |
Castonguay A, Hecht SS. Synthesis of carbon-14 labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Journal of Labelled Compounds and Radiopharmaceuticals. 22: 23-28. DOI: 10.1002/Jlcr.2580220104 |
0.365 |
|
| 1984 |
Hoffmann D, Rivenson A, Amin S, Hecht SS. Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats. Journal of Cancer Research and Clinical Oncology. 108: 81-6. PMID 6746721 DOI: 10.1007/Bf00390978 |
0.554 |
|
| 1984 |
Hecht SS, Morrison JB, Young R. N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine. Carcinogenesis. 5: 979-81. PMID 6733859 DOI: 10.1093/Carcin/5.7.979 |
0.301 |
|
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