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Stephen S. Hecht - Publications

Affiliations: 
1996- Pharmacy University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
mechanisms of chemical carcinogenesis in humans, including those related to tobacco-induced cancer
Website:
http://www.pharmacy.umn.edu/faculty/hecht_stephen/

429 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Tevis DS, Willmore A, Bhandari D, Bowman B, Biren C, Kenwood BM, Jacob P, Liu J, Bello K, Hecht SS, Carmella SG, Chen M, Gaudreau E, Bienvenu JF, Blount BC, et al. Large Differences in Urinary Benzene Metabolite S-Phenylmercapturic Acid Quantitation: A Comparison of Five LC-MS-MS Methods. Journal of Analytical Toxicology. PMID 33025019 DOI: 10.1093/jat/bkaa137  0.48
2020 Travers MJ, Rivard C, Sharma E, Retzky S, Yucesoy B, Goniewicz ML, Stanton CA, Chen J, Callahan-Lyon P, Kimmel HL, Xia B, Wang Y, Sosnoff CS, De Jesús VR, Blount BC, ... Hecht SS, et al. Biomarkers of Exposure among USA Adult Hookah Users: Results from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (2013-2014). International Journal of Environmental Research and Public Health. 17. PMID 32887496 DOI: 10.3390/ijerph17176403  0.4
2020 Guo J, Chen H, Upadhyaya P, Zhao Y, Turesky RJ, Hecht SS. Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissue DNA of rats exposed to tobacco-specific nitrosamines and in lung and leukocyte DNA of cigarette smokers and non-smokers. Chemical Research in Toxicology. PMID 32833447 DOI: 10.1021/acs.chemrestox.0c00265  0.52
2020 Luo K, Carmella SG, Zhao Y, Tang MK, Hecht SS. Identification and quantification of phenanthrene ortho-quinones in human urine and their association with lipid peroxidation. Environmental Pollution (Barking, Essex : 1987). 266: 115342. PMID 32805605 DOI: 10.1016/j.envpol.2020.115342  0.48
2020 Xia B, Blount BC, Guillot T, Brosius C, Li Y, Van Bemmel DM, Kimmel HL, Chang CM, Borek N, Edwards KC, Lawrence C, Hyland A, Goniewicz ML, Pine BN, Xia Y, ... ... Hecht SS, et al. Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014). Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 32716026 DOI: 10.1093/ntr/ntaa110  0.36
2020 Paiano V, Maertens L, Guidolin V, Yang J, Balbo S, Hecht SS. Quantitative Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers. Chemical Research in Toxicology. PMID 32635726 DOI: 10.1021/acs.chemrestox.0c00223  0.44
2020 Hu Q, Corral P, Narayanapillai SC, Leitzman P, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C. Oral dosing of dihydromethysticin ahead of tobacco carcinogen NNK effectively prevents lung tumorigenesis in A/J mice. Chemical Research in Toxicology. PMID 32476407 DOI: 10.1021/acs.chemrestox.0c00161  0.52
2020 Cheng G, Reisinger SA, Shields PG, Hatsukami DK, Balbo S, Hecht SS. Quantitation by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry of DNA adducts derived from methyl glyoxal and carboxyethylating agents in leukocytes of smokers and non-smokers. Chemico-Biological Interactions. 109140. PMID 32442416 DOI: 10.1016/j.cbi.2020.109140  0.44
2020 Luo K, Hochalter JB, Carmella SG, Hecht SS. Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1141: 122023. PMID 32109746 DOI: 10.1016/j.jchromb.2020.122023  0.48
2020 Wang Y, Chanickal Narayanapillai S, Tessier KM, Strayer LG, Upadhyaya P, Hu Q, Kingston R, Salloum RG, Lu J, Hecht SS, Hatsukami DK, Fujioka N, Xing C. The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 32102948 DOI: 10.1158/1940-6207.CAPR-19-0501  0.52
2020 Peterson LA, Balbo S, Fujioka N, Hatsukami DK, Hecht SS, Murphy SE, Stepanov I, Tretyakova N, Turesky RJ, Villalta PW. Applying tobacco, environmental and dietary-related biomarkers to understand cancer etiology and evaluate prevention strategies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 32051197 DOI: 10.1158/1055-9965.EPI-19-1356  0.76
2020 Cheng YC, Reyes-Guzman CM, Christensen CH, Rostron BL, Edwards KC, Wang L, Feng J, Jarrett JM, Ward CD, Xia B, Kimmel HL, Conway K, Leggett C, Taylor K, Lawrence C, ... ... Hecht SS, et al. Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013-14). Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 31988072 DOI: 10.1158/1055-9965.EPI-19-0766  0.44
2020 Chen M, Carmella SG, Li Y, Zhao Y, Hecht SS. Resolution and quantitation of mercapturic acids derived from crotonaldehyde, methacrolein, and methyl vinyl ketone in the urine of smokers and non-smokers. Chemical Research in Toxicology. PMID 31957442 DOI: 10.1021/acs.chemrestox.9b00491  0.48
2019 Tidey JW, Colby SM, Denlinger-Apte RL, Goodwin C, Cioe PA, Cassidy RN, Swift RM, Lindgren BR, Rubin N, Murphy SE, Hecht SS, Hatsukami DK, Donny EC. Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 21: S38-S45. PMID 31867650 DOI: 10.1093/ntr/ntz133  0.76
2019 Hatsukami D, Meier E, Lindgren BR, Anderson A, Reisinger S, Norton K, Strayer L, Jensen J, Dick L, Murphy S, Carmella S, Tang MK, Chen M, Hecht SS, O'Connor RJ, et al. A Randomized Clinical Trial Examining the Effects of Instructions for Electronic Cigarette Use on Smoking-Related Behaviors, and Biomarkers of Exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31828315 DOI: 10.1093/ntr/ntz233  0.76
2019 Boldry EJ, Yuan JM, Carmella SG, Wang R, Tessier K, Hatsukami DK, Hecht SS, Tretyakova N. Effects of 2-phenethyl isothiocyanate on metabolism of 1,3-butadiene in smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 31771940 DOI: 10.1158/1940-6207.CAPR-19-0296  0.48
2019 Meier E, Vandrey R, Rubin N, Pacek LR, Jensen JA, Donny EC, Hecht SS, Carmella SG, Murphy SE, Luo X, Stepanov I, Ikuemonisan J, Severson H, al'Absi M, Hatsukami DK. Cigarette Smokers vs. Co-users of Cannabis and Cigarettes: Exposure to Toxicants. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31616939 DOI: 10.1093/ntr/ntz199  0.56
2019 Meier E, Lindgren BR, Anderson A, Reisinger SA, Norton KJ, Jensen J, Strayer L, Dick L, Tang MK, Chen M, Carmella SG, Hecht SS, Murphy SE, Yang J, Stepanov I, et al. A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31321423 DOI: 10.1093/ntr/ntz055  0.76
2019 Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, et al. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. The American Journal of Clinical Nutrition. PMID 31268126 DOI: 10.1093/ajcn/nqz122  0.4
2019 McElroy JP, Carmella SG, Heskin AK, Tang MK, Murphy SE, Reisinger SA, Jensen JA, Hatsukami DK, Hecht SS, Shields PG. Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage. Plos One. 14: e0218386. PMID 31251764 DOI: 10.1371/journal.pone.0218386  0.56
2019 Hatsukami DK, Luo X, Heskin AK, Tang MK, Carmella SG, Jensen J, Robinson JD, Vandrey R, Drobes DJ, Strasser AA, al'Absi M, Leischow S, Cinciripini PM, Koopmeiners J, Ikuemonisan J, ... ... Hecht SS, et al. Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects. Addiction (Abingdon, England). PMID 31140663 DOI: 10.1111/add.14695  0.48
2019 Carmella SG, Heskin AK, Tang MK, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al'Absi M, ... ... Hecht SS, et al. Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation. Plos One. 14: e0215853. PMID 31022220 DOI: 10.1371/journal.pone.0215853  0.56
2019 Ma B, Stepanov I, Hecht SS. Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke. Toxics. 7. PMID 30893918 DOI: 10.3390/toxics7010016  0.36
2019 Ma B, Villalta PW, Hochalter JB, Stepanov I, Hecht SS. Methyl DNA Phosphate Adduct Formation in Lung Tumor Tissue and Adjacent Normal Tissue of Lung Cancer Patients. Carcinogenesis. PMID 30873516 DOI: 10.1093/carcin/bgz053  0.76
2019 Li Y, Ma B, Cao Q, Balbo S, Zhao L, Upadhyaya P, Hecht SS. Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N´-Nitrosonornicotine. Chemical Research in Toxicology. PMID 30740971 DOI: 10.1021/acs.chemrestox.9b00007  0.52
2019 Stram DO, Park SL, Haiman CA, Murphy SE, Patel Y, Hecht SS, Le Marchand L. Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update. Journal of the National Cancer Institute. PMID 30698722 DOI: 10.1093/jnci/djy206  0.56
2019 Yuan JM, Grouls M, Carmella SG, Wang R, Heskin A, Jiang Y, Tan YT, Adams-Haduch J, Gao YT, Hecht SS. Prediagnostic levels of urinary 8-epi-prostaglandin F2α and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma. Carcinogenesis. PMID 30615102 DOI: 10.1093/carcin/bgy180  0.48
2019 Chen M, Carmella SG, Sipe C, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al'Absi M, ... ... Hecht SS, et al. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein. Plos One. 14: e0210104. PMID 30608961 DOI: 10.1371/journal.pone.0210104  0.56
2018 Goniewicz ML, Smith DM, Edwards KC, Blount BC, Caldwell KL, Feng J, Wang L, Christensen C, Ambrose B, Borek N, van Bemmel D, Konkel K, Erives G, Stanton CA, Lambert E, ... ... Hecht SS, et al. Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes. Jama Network Open. 1: e185937. PMID 30646298 DOI: 10.1001/jamanetworkopen.2018.5937  0.36
2018 Wang Y, Wong LY, Meng L, Pittman EN, Trinidad DA, Hubbard KL, Etheredge A, Del Valle-Pinero AY, Zamoiski R, van Bemmel DM, Borek N, Patel V, Kimmel HL, Conway KP, Lawrence C, ... ... Hecht SS, et al. Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014). Environment International. 123: 201-208. PMID 30530162 DOI: 10.1016/j.envint.2018.11.068  0.4
2018 Hatsukami DK, Luo X, Jensen JA, al'Absi M, Allen SS, Carmella SG, Chen M, Cinciripini PM, Denlinger-Apte R, Drobes DJ, Koopmeiners JS, Lane T, Le CT, Leischow S, Luo K, ... ... Hecht SS, et al. Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. Jama. 320: 880-891. PMID 30193275 DOI: 10.1001/jama.2018.11473  0.56
2018 Murphy SE, Park SL, Balbo S, Haiman CA, Hatsukami DK, Patel Y, Peterson LA, Stepanov I, Stram DO, Tretyakova N, Hecht SS, Le Marchand L. Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers. Npj Precision Oncology. 2: 17. PMID 30155522 DOI: 10.1038/s41698-018-0057-y  0.56
2018 Yuan JM, Carmella SG, Wang R, Tan YT, Adams-Haduch J, Gao YT, Hecht SS. Relationship of the Oxidative Damage Biomarker 8-epi-prostaglandin F2α to Risk of Lung Cancer Development in the Shanghai Cohort Study. Carcinogenesis. PMID 29726912 DOI: 10.1093/carcin/bgy060  0.48
2018 Carlson ES, Upadhyaya P, Villalta PW, Ma B, Hecht SS. Analysis and Identification of 2'-Deoxyadenosine-derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. PMID 29651838 DOI: 10.1021/acs.chemrestox.8b00056  0.76
2018 Kovi RC, Johnson CS, Balbo S, Hecht SS, O'Sullivan MG. Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products. Toxicologic Pathology. 192623317751573. PMID 29390940 DOI: 10.1177/0192623317751573  0.44
2017 Upadhyaya P, Zarth AT, Fujioka N, Fritz VA, Hecht SS. Identification and analysis of a mercapturic acid conjugate of indole-3-methyl isothiocyanate in the urine of humans who consumed cruciferous vegetables. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1072: 341-346. PMID 29223047 DOI: 10.1016/j.jchromb.2017.12.001  0.52
2017 Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS. Identification of More Than One Hundred Structurally Unique DNA-Phosphate Adducts Formed During Rat Lung Carcinogenesis by the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. PMID 29194532 DOI: 10.1093/carcin/bgx135  0.76
2017 Ma B, Zarth AT, Carlson ES, Villalta PW, Stepanov I, Hecht SS. Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Mutagenesis. PMID 29186507 DOI: 10.1093/mutage/gex031  0.76
2017 Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS. Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. PMID 29131934 DOI: 10.1021/acs.chemrestox.7b00281  0.76
2017 Villalta PW, Hochalter JB, Hecht SS. Ultra-sensitive High Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung. Analytical Chemistry. PMID 29111668 DOI: 10.1021/acs.analchem.7b02856  0.76
2017 Carlson ES, Upadhyaya P, Hecht SS. A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s. Journal of Visualized Experiments : Jove. PMID 28994777 DOI: 10.3791/56312  0.52
2017 Puppala M, Narayanapillai SC, Leitzman P, Sun H, Upadhyaya P, O'Sullivan MG, Hecht SS, Xing C. Pilot in vivo structure-activity relationship of dihydromethys-ticin in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced O6-methylguanine and lung tumor in A/J mice. Journal of Medicinal Chemistry. PMID 28806079 DOI: 10.1021/acs.jmedchem.7b00921  0.52
2017 Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS. Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon. Chemico-Biological Interactions. PMID 28693886 DOI: 10.1016/j.cbi.2017.07.005  0.76
2017 Khariwala SS, Ma B, Ruszczak C, Carmella SG, Lindgren BR, Hatsukami DK, Hecht SS, Stepanov I. High level of tobacco carcinogen-derived DNA damage in oral cells is an independent predictor of oral/head and neck cancer risk in smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 28679497 DOI: 10.1158/1940-6207.CAPR-17-0140  0.76
2017 Kassem NOF, Kassem NO, Liles S, Zarth AT, Jackson SR, Daffa RM, Chatfield DA, Carmella SG, Hecht SS, Hovell MF. Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco Secondhand Smoke: Implications for regulating hookah tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28591850 DOI: 10.1093/ntr/ntx133  0.48
2017 Park SL, Murphy SE, Wilkens LR, Stram DO, Hecht SS, Le Marchand L. Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. Plos One. 12: e0178435. PMID 28542511 DOI: 10.1371/journal.pone.0178435  0.56
2017 Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, et al. Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00343.2016. PMID 28522563 DOI: 10.1152/ajplung.00343.2016  0.36
2017 Michel AK, Zarth AT, Upadhyaya P, Hecht SS. Identification of 4-(3-Pyridyl)-4-oxobutyl-2'-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens. Acs Omega. 2: 1180-1190. PMID 28393135 DOI: 10.1021/acsomega.7b00072  0.52
2017 Yuan JM, Nelson HH, Carmella SG, Wang R, Kuriger-Laber J, Jin A, Adams-Haduch J, Hecht SS, Koh WP, Murphy SE. CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study. Carcinogenesis. PMID 28182203 DOI: 10.1093/carcin/bgx012  0.56
2017 Yang J, Carmella SG, Hecht SS. Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1044: 127-131. PMID 28107699 DOI: 10.1016/j.jchromb.2017.01.008  0.48
2017 Peterson LA, Hecht SS. Tobacco, e-cigarettes, and child health. Current Opinion in Pediatrics. PMID 28059903 DOI: 10.1097/MOP.0000000000000456  0.4
2016 Carlson ES, Upadhyaya P, Hecht SS. Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines. Chemical Research in Toxicology. 29: 2194-2205. PMID 27989137 DOI: 10.1021/acs.chemrestox.6b00384  0.52
2016 Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields P, al'Absi M. Reduced Nicotine Content Cigarettes and Use of Alternative Nicotine Products: Exploratory Trial. Addiction (Abingdon, England). PMID 27614097 DOI: 10.1111/add.13603  0.56
2016 Fujioka N, Ransom BW, Carmella SG, Upadhyaya P, Lindgren BR, Roper-Batker A, Hatsukami DK, Fritz VA, Rohwer C, Hecht SS. Harnessing the power of cruciferous vegetables: developing a biomarker for Brassica vegetable consumption using urinary 3,3'-diindolylmethane. Cancer Prevention Research (Philadelphia, Pa.). PMID 27538743 DOI: 10.1158/1940-6207.CAPR-16-0136  0.76
2016 Patel YM, Park SL, Carmella SG, Paiano V, Olvera N, Stram DO, Haiman CA, Le Marchand L, Hecht SS. Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. Plos One. 11: e0156203. PMID 27275760 DOI: 10.1371/journal.pone.0156203  0.96
2016 Mercincavage M, Souprountchouk V, Tang KZ, Dumont RL, Wileyto EP, Carmella SG, Hecht SS, Strasser AA. A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 27197288 DOI: 10.1158/1055-9965.EPI-15-1088  0.96
2016 Yershova K, Yuan JM, Wang R, Valentin L, Watson C, Gao YT, Hecht S, Stepanov I. Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study. International Journal of Cancer. PMID 27163125 DOI: 10.1002/ijc.30178  0.96
2016 Yuan JM, Murphy SE, Stepanov I, Wang R, Carmella SG, Nelson HH, Hatsukami DK, Hecht SS. 2-Phenethyl isothiocyanate, glutathione S-transferase M1 and T1 polymorphisms, and detoxification of volatile organic carcinogens and toxicants in tobacco smoke. Cancer Prevention Research (Philadelphia, Pa.). PMID 27099270 DOI: 10.1158/1940-6207.CAPR-16-0032  0.56
2016 Haiman CA, Patel YM, Stram DO, Carmella SG, Chen M, Wilkens LR, Le Marchand L, Hecht SS. Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort. Plos One. 11: e0150641. PMID 26959369 DOI: 10.1371/journal.pone.0150641  0.48
2016 Hecht SS, Yuan JM, Stepanov I, Murphy SE, Wang R, Allen SS, Jensen JA, Strayer L, Adams-Haduch J, Upadhyaya P, Le C, Kurzer MS, Nelson HH, Yu MC, Hatsukami DK. Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers. Cancer Prevention Research (Philadelphia, Pa.). PMID 26951845 DOI: 10.1158/1940-6207.CAPR-15-0380  0.96
2016 Haynes CL, Hecht S. Chemical Research in Toxicology Editorial Advisory Board Members' Favorite CRT Articles. Chemical Research in Toxicology. 29: 133. PMID 26876229 DOI: 10.1021/acs.chemrestox.6b00025  0.96
2016 Fujioka N, Fritz V, Upadhyaya P, Kassie F, Hecht SS. Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: a tribute to lee w. wattenberg. Molecular Nutrition & Food Research. PMID 26840393 DOI: 10.1002/mnfr.201500889  0.52
2016 Zarth AT, Upadhyaya P, Yang J, Hecht SS. DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats. Chemical Research in Toxicology. PMID 26808005 DOI: 10.1021/acs.chemrestox.5b00520  0.52
2016 Khammanivong A, Anandharaj A, Qian X, Song JM, Upadhyaya P, Balbo S, Bandyopadhyay D, Dickerson EB, Hecht SS, Kassie F. Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. Molecular Carcinogenesis. PMID 26785143 DOI: 10.1002/mc.22459  0.96
2016 Narayanapillai S, von Weymarn L, Carmella S, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy S, Xing C. Dietary Dihydromethysticin (DHM) Increases Glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-Butanol (NNAL) in A/J Mice, Potentially Enhancing its Detoxification. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26744252 DOI: 10.1124/dmd.115.068387  0.96
2015 Hecht SS, Stepanov I, Carmella SG. Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines. Accounts of Chemical Research. PMID 26678241 DOI: 10.1021/acs.accounts.5b00472  0.96
2015 Yuan JM, Nelson HH, Butler LM, Carmella SG, Wang R, Kuriger-Laber JK, Adams-Haduch J, Hecht SS, Gao YT, Murphy SE. Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai Cohort Study. International Journal of Cancer. Journal International Du Cancer. PMID 26662855 DOI: 10.1002/ijc.29963  0.96
2015 Yang J, Villalta PW, Upadhyaya P, Hecht SS. Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine. Chemical Research in Toxicology. PMID 26633576 DOI: 10.1021/acs.chemrestox.5b00425  0.96
2015 Peiffer DS, Wang LS, Zimmerman NP, Carmella SG, Kuo CT, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner G. Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer. Cancer Immunology Research. PMID 26603620 DOI: 10.1158/2326-6066.CIR-15-0091  0.96
2015 Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert P, Hecht SS, Bucher JR, Stewart BW, Baan R, Cogliano VJ, et al. Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environmental Health Perspectives. PMID 26600562 DOI: 10.1289/ehp.1509912  0.96
2015 Kotandeniya D, Carmella SG, Pillsbury ME, Hecht SS. Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1007: 121-126. PMID 26595795 DOI: 10.1016/j.jchromb.2015.10.012  0.96
2015 Wang H, Park SL, Stram DO, Haiman CA, Wilkens LR, Hecht SS, Kolonel LN, Murphy SE, Le Marchand L. Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study. American Journal of Epidemiology. PMID 26568573 DOI: 10.1093/aje/kwv138  0.96
2015 Zarth AT, Murphy SE, Hecht SS. Benzene oxide is a substrate for glutathione S-Transferases. Chemico-Biological Interactions. PMID 26554337 DOI: 10.1016/j.cbi.2015.11.005  0.96
2015 Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S. Screening for DNA Alkylation Mono and Crosslinked Adducts with a Comprehensive LC-MS(3) Adductomic Approach. Analytical Chemistry. PMID 26509677 DOI: 10.1021/acs.analchem.5b02759  0.36
2015 Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, et al. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. The New England Journal of Medicine. 373: 1340-1349. PMID 26422724 DOI: 10.1056/NEJMsa1502403  0.96
2015 Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS. Comprehensive High Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology. PMID 26398225 DOI: 10.1021/acs.chemrestox.5b00318  0.96
2015 Park SL, Carmella SG, Chen M, Patel Y, Stram DO, Haiman CA, Le Marchand L, Hecht SS. Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. Plos One. 10: e0124841. PMID 26053186 DOI: 10.1371/journal.pone.0124841  0.96
2015 Hatsukami DK, Severson H, Anderson A, Vogel RI, Jensen J, Broadbent B, Murphy SE, Carmella S, Hecht SS. Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching. Tobacco Control. PMID 25991608 DOI: 10.1136/tobaccocontrol-2014-052080  0.96
2015 Khariwala SS, Carmella SG, Stepanov I, Bandyopadhyay D, Nelson HH, Yueh B, Hatsukami DK, Hecht SS. Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer. The Laryngoscope. 125: 1844-8. PMID 25877866 DOI: 10.1002/lary.25290  0.96
2015 Hecht SS, Koh WP, Wang R, Chen M, Carmella SG, Murphy SE, Yuan JM. Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home. Plos One. 10: e0120023. PMID 25807518 DOI: 10.1371/journal.pone.0120023  0.96
2015 Zabala V, Tong M, Yu R, Ramirez T, Yalcin EB, Balbo S, Silbermann E, Deochand C, Nunez K, Hecht S, de la Monte SM. Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease. Alcohol and Alcoholism (Oxford, Oxfordshire). 50: 118-31. PMID 25618784 DOI: 10.1093/alcalc/agu083  0.96
2015 Kotandeniya D, Carmella SG, Ming X, Murphy SE, Hecht SS. Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine. Analytical Chemistry. 87: 1514-7. PMID 25544129 DOI: 10.1021/ac504047j  0.96
2015 Park SL, Carmella SG, Ming X, Vielguth E, Stram DO, Le Marchand L, Hecht SS. Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 561-9. PMID 25542827 DOI: 10.1158/1055-9965.EPI-14-1054  0.96
2015 Hatsukami DK, Stepanov I, Severson H, Jensen JA, Lindgren BR, Horn K, Khariwala SS, Martin J, Carmella SG, Murphy SE, Hecht SS. Evidence supporting product standards for carcinogens in smokeless tobacco products. Cancer Prevention Research (Philadelphia, Pa.). 8: 20-6. PMID 25524878 DOI: 10.1158/1940-6207.CAPR-14-0250  0.96
2015 Walton KM, Abrams DB, Bailey WC, Clark D, Connolly GN, Djordjevic MV, Eissenberg TE, Fiore MC, Goniewicz ML, Haverkos L, Hecht SS, Henningfield JE, Hughes JR, Oncken CA, Postow L, et al. NIH electronic cigarette workshop: developing a research agenda. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 259-69. PMID 25335949 DOI: 10.1093/ntr/ntu214  0.96
2015 Hecht SS, Carmella SG, Kotandeniya D, Pillsbury ME, Chen M, Ransom BW, Vogel RI, Thompson E, Murphy SE, Hatsukami DK. Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 704-9. PMID 25335945 DOI: 10.1093/ntr/ntu218  0.96
2015 Upadhyaya P, Hecht SS. Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 524-9. PMID 25324430 DOI: 10.1093/ntr/ntu206  0.96
2014 Kassem NO, Kassem NO, Jackson SR, Liles S, Daffa RM, Zarth AT, Younis MA, Carmella SG, Hofstetter CR, Chatfield DA, Matt GE, Hecht SS, Hovell MF. Benzene uptake in Hookah smokers and non-smokers attending Hookah social events: regulatory implications. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 2793-809. PMID 25416714 DOI: 10.1158/1055-9965.EPI-14-0576  0.96
2014 Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats. Carcinogenesis. 35: 2798-806. PMID 25269804 DOI: 10.1093/carcin/bgu204  0.76
2014 Jing M, Wang Y, Upadhyaya P, Jain V, Yuan JM, Hatsukami DK, Hecht SS, Stepanov I. Liquid chromatography-electrospray ionization-tandem mass spectrometry quantitation of urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation in smokers. Chemical Research in Toxicology. 27: 1547-55. PMID 25098652 DOI: 10.1021/tx5001915  0.96
2014 Hecht SS, Hochalter JB. Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide. Mutagenesis. 29: 351-6. PMID 25053834 DOI: 10.1093/mutage/geu024  0.96
2014 Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C. Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 35: 2365-72. PMID 25053626 DOI: 10.1093/carcin/bgu149  0.96
2014 Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, ... ... Hecht SS, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research (Philadelphia, Pa.). 7: 813-23. PMID 24913818 DOI: 10.1158/1940-6207.CAPR-14-0103  0.96
2014 Rietjens IM, Cohen SM, Fukushima S, Gooderham NJ, Hecht S, Marnett LJ, Smith RL, Adams TB, Bastaki M, Harman CG, Taylor SV. Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes. Chemical Research in Toxicology. 27: 1092-103. PMID 24857813 DOI: 10.1021/tx500109s  0.96
2014 Hecht SS. It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco. Cancer Prevention Research (Philadelphia, Pa.). 7: 639-47. PMID 24806664 DOI: 10.1158/1940-6207.CAPR-14-0095  0.96
2014 Kennedy GD, Nukaya M, Moran SM, Glover E, Weinberg S, Balbo S, Hecht SS, Pitot HC, Drinkwater NR, Bradfield CA. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 140: 135-43. PMID 24718703 DOI: 10.1093/toxsci/kfu065  0.96
2014 Marnett LJ, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Rietjens IM, Smith RL, Adams TB, Bastaki M, Harman CL, McGowen MM, Taylor SV. GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients. Journal of Food Science. 79: R428-41. PMID 24689743 DOI: 10.1111/1750-3841.12407  0.96
2014 Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, Kuo CT, Siddiqui J, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prevention Research (Philadelphia, Pa.). 7: 574-84. PMID 24667581 DOI: 10.1158/1940-6207.CAPR-14-0003  0.96
2014 Zarth AT, Cheng G, Zhang Z, Wang M, Villalta PW, Balbo S, Hecht SS. Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans. Chemico-Biological Interactions. 215: 40-5. PMID 24632417 DOI: 10.1016/j.cbi.2014.03.002  0.96
2014 Zarth AT, Carmella SG, Le CT, Hecht SS. Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 953: 126-31. PMID 24608133 DOI: 10.1016/j.jchromb.2014.02.001  0.96
2014 Kassem NO, Daffa RM, Liles S, Jackson SR, Kassem NO, Younis MA, Mehta S, Chen M, Jacob P, Carmella SG, Chatfield DA, Benowitz NL, Matt GE, Hecht SS, Hovell MF. Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 961-75. PMID 24590387 DOI: 10.1093/ntr/ntu016  0.96
2014 Balbo S, Hecht SS, Upadhyaya P, Villalta PW. Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures. Analytical Chemistry. 86: 1744-52. PMID 24410521 DOI: 10.1021/ac403565m  0.96
2014 Yuan JM, Butler LM, Stepanov I, Hecht SS. Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer. Cancer Research. 74: 401-11. PMID 24408916 DOI: 10.1158/0008-5472.CAN-13-3178  0.96
2014 Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O'Sullivan MG, Hecht SS, Lu J, Xing C. Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 7: 86-96. PMID 24403291 DOI: 10.1158/1940-6207.CAPR-13-0301  0.96
2014 Hecht SS, Szabo E. Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer. Cancer Prevention Research (Philadelphia, Pa.). 7: 1-8. PMID 24403288 DOI: 10.1158/1940-6207.CAPR-13-0371  0.96
2014 Fujioka N, Ainslie-Waldman CE, Upadhyaya P, Carmella SG, Fritz VA, Rohwer C, Fan Y, Rauch D, Le C, Hatsukami DK, Hecht SS. Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 282-7. PMID 24357105 DOI: 10.1158/1055-9965.EPI-13-0645  0.96
2014 Mallery SR, Tong M, Michaels GC, Kiyani AR, Hecht SS. Clinical and biochemical studies support smokeless tobacco's carcinogenic potential in the human oral cavity. Cancer Prevention Research (Philadelphia, Pa.). 7: 23-32. PMID 24265177 DOI: 10.1158/1940-6207.CAPR-13-0262  0.96
2014 Stepanov I, Sebero E, Wang R, Gao YT, Hecht SS, Yuan JM. Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites. International Journal of Cancer. Journal International Du Cancer. 134: 2278-83. PMID 24243522 DOI: 10.1002/ijc.28575  0.96
2014 Yuan JM, Butler LM, Gao YT, Murphy SE, Carmella SG, Wang R, Nelson HH, Hecht SS. Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study. Carcinogenesis. 35: 339-45. PMID 24148823 DOI: 10.1093/carcin/bgt352  0.96
2014 Thomas JL, Hecht SS, Luo X, Ming X, Ahluwalia JS, Carmella SG. Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 26-32. PMID 23892827 DOI: 10.1093/ntr/ntt110  0.96
2014 Peterson LA, Hecht SS, Urban AM. Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.02080-8  0.96
2014 Stoner GD, Wang LS, Kresty LA, Peiffer D, Kuo CT, Huang YW, Wang D, Ransom B, Carmella S, Hecht SS. An approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer Methods in Pharmacology and Toxicology. 107-133. DOI: 10.1007/978-1-4614-9227-6-5  0.96
2014 Balbo S, Hecht SS. Quantitation of acetaldehyde-DNA adducts: Biomarkers of alcohol consumption Methods in Pharmacology and Toxicology. 237-248. DOI: 10.1007/978-1-4614-9227-6-11  0.96
2013 Hecht SS. Continuing excellence for chemical research in toxicology. Chemical Research in Toxicology. 26: 1. PMID 24490668 DOI: 10.1021/tx300497e  0.96
2013 Hecht SS. Introducing Perspectives on Statistical Trends (POST). Chemical Research in Toxicology. 26: 1775. PMID 24328292 DOI: 10.1021/tx400413x  0.96
2013 Zhao L, Balbo S, Wang M, Upadhyaya P, Khariwala SS, Villalta PW, Hecht SS. Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study. Chemical Research in Toxicology. 26: 1526-35. PMID 24001146 DOI: 10.1021/tx400235x  0.96
2013 Ainslie-Waldman CE, Simpkins SW, Upadhyaya P, Carmella SG, Hecht SS, Trudo SP. Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 62: 188-93. PMID 23994708 DOI: 10.1016/j.fct.2013.08.055  0.96
2013 Carmella SG, Chen M, Zarth A, Hecht SS. High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 935: 36-40. PMID 23934173 DOI: 10.1016/j.jchromb.2013.07.004  0.96
2013 Wang M, Cheng G, Khariwala SS, Bandyopadhyay D, Villalta PW, Balbo S, Hecht SS. Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation. Chemico-Biological Interactions. 206: 83-9. PMID 23911671 DOI: 10.1016/j.cbi.2013.07.010  0.96
2013 Carmella SG, Ming X, Olvera N, Brookmeyer C, Yoder A, Hecht SS. High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers. Chemical Research in Toxicology. 26: 1209-17. PMID 23837805 DOI: 10.1021/tx400121n  0.96
2013 Balbo S, James-Yi S, Johnson CS, O'Sullivan MG, Stepanov I, Wang M, Bandyopadhyay D, Kassie F, Carmella S, Upadhyaya P, Hecht SS. (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. Carcinogenesis. 34: 2178-83. PMID 23671129 DOI: 10.1093/carcin/bgt162  0.96
2013 Hatsukami DK, Hertsgaard LA, Vogel RI, Jensen JA, Murphy SE, Hecht SS, Carmella SG, al'Absi M, Joseph AM, Allen SS. Reduced nicotine content cigarettes and nicotine patch. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 1015-24. PMID 23603206 DOI: 10.1158/1055-9965.EPI-12-1439  0.96
2013 Hecht SS, Hochalter JB, Carmella SG, Zhang Y, Rauch DM, Fujioka N, Jensen J, Hatsukami DK. Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 18: 144-50. PMID 23336104 DOI: 10.3109/1354750X.2012.753553  0.96
2013 Stepanov I, Muzic J, Le CT, Sebero E, Villalta P, Ma B, Jensen J, Hatsukami D, Hecht SS. Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 26: 37-45. PMID 23252610 DOI: 10.1021/tx300282k  0.96
2013 Stepanov I, Yershova K, Carmella S, Upadhyaya P, Hecht SS. Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 1305-10. PMID 23212437 DOI: 10.1093/ntr/nts249  0.96
2013 Avila-Tang E, Al-Delaimy WK, Ashley DL, Benowitz N, Bernert JT, Kim S, Samet JM, Hecht SS. Assessing secondhand smoke using biological markers. Tobacco Control. 22: 164-71. PMID 22940677 DOI: 10.1136/tobaccocontrol-2011-050298  0.96
2013 Knezevich A, Muzic J, Hatsukami DK, Hecht SS, Stepanov I. Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 591-5. PMID 22923602 DOI: 10.1093/ntr/nts172  0.96
2013 Hecht SS, Murphy SE, Stepanov I, Nelson HH, Yuan JM. Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study. Cancer Letters. 334: 34-8. PMID 22824243 DOI: 10.1016/j.canlet.2012.07.016  0.96
2013 Khariwala SS, Carmella SG, Stepanov I, Fernandes P, Lassig AA, Yueh B, Hatsukami D, Hecht SS. Elevated levels of 1-hydroxypyrene and N'-nitrosonornicotine in smokers with head and neck cancer: A matched control study. Head & Neck. 35: 1096-100. PMID 22807150 DOI: 10.1002/hed.23085  0.96
2013 Radwan G, Hecht SS, Carmella SG, Loffredo CA. Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 130-8. PMID 22573723 DOI: 10.1093/ntr/nts099  0.96
2013 Vardavas CI, Fthenou E, Patelarou E, Bagkeris E, Murphy S, Hecht SS, Connolly GN, Chatzi L, Kogevinas M. Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations. Tobacco Control. 22: 194-200. PMID 22253001 DOI: 10.1136/tobaccocontrol-2011-050144  0.96
2013 Marnett LJ, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Rietjens IMCM, Smith RL, Adams TB, Hallagan JB, Harman C, McGowen MM, Taylor SV. Gras: Flavoring substances 26 Food Technology. 67: 38-43.  0.96
2012 Hecht SS. Lung carcinogenesis by tobacco smoke. International Journal of Cancer. Journal International Du Cancer. 131: 2724-32. PMID 22945513 DOI: 10.1002/ijc.27816  0.96
2012 Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochemical and Biophysical Research Communications. 424: 18-21. PMID 22727907 DOI: 10.1016/j.bbrc.2012.06.012  0.96
2012 Wang J, Zhong Y, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Hecht SS, Zimmerman CL. Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation. The Journal of Pharmacology and Experimental Therapeutics. 342: 750-60. PMID 22674470 DOI: 10.1124/jpet.112.194118  0.96
2012 Eisenbrand G, Gates KS, Hecht SS, Janzowski C, Keefer LK, Marnett LJ, Tannenbaum SR. Richard Loeppky (1937-2012). Chemical Research in Toxicology. 25: 1155-6. PMID 22632260 DOI: 10.1021/tx300219b  0.96
2012 Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Smith GD, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. International Journal of Epidemiology. 41: 686-704. PMID 22596931 DOI: 10.1093/ije/dys010  0.96
2012 Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK, Hecht SS. Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol. Mutagenesis. 27: 485-90. PMID 22406526 DOI: 10.1093/mutage/ges008  0.96
2012 Balbo S, Meng L, Bliss RL, Jensen JA, Hatsukami DK, Hecht SS. Kinetics of DNA adduct formation in the oral cavity after drinking alcohol. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 601-8. PMID 22301829 DOI: 10.1158/1055-9965.EPI-11-1175  0.96
2012 Yuan JM, Gao YT, Wang R, Chen M, Carmella SG, Hecht SS. Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. Carcinogenesis. 33: 804-9. PMID 22298640 DOI: 10.1093/carcin/bgs026  0.96
2012 Stepanov I, Jensen J, Biener L, Bliss RL, Hecht SS, Hatsukami DK. Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 1241-5. PMID 22259150 DOI: 10.1093/ntr/ntr292  0.96
2012 Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis. 33: 101-7. PMID 22045030 DOI: 10.1093/carcin/bgr229  0.96
2012 Stepanov I, Biener L, Knezevich A, Nyman AL, Bliss R, Jensen J, Hecht SS, Hatsukami DK. Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 274-81. PMID 22039075 DOI: 10.1093/ntr/ntr209  0.96
2012 Khariwala SS, Hatsukami D, Hecht SS. Tobacco carcinogen metabolites and DNA adducts as biomarkers in head and neck cancer: potential screening tools and prognostic indicators. Head & Neck. 34: 441-7. PMID 21618325 DOI: 10.1002/hed.21705  0.96
2012 Stepanov I, Knezevich A, Zhang L, Watson CH, Hatsukami DK, Hecht SS. Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry. Tobacco Control. 21: 44-8. PMID 21602537 DOI: 10.1136/tc.2010.042192  0.96
2012 Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC. Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). International Journal of Cancer. Journal International Du Cancer. 130: 1338-46. PMID 21544809 DOI: 10.1002/ijc.26162  0.96
2012 Hecht SS. Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 18-28. PMID 21324834 DOI: 10.1093/ntr/ntq216  0.96
2012 Carmella SG, Chen M, Han S, Briggs A, Jensen J, Hatsukami DK, Hecht SS. Correction to Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers (Chemical Research Toxicology (2009) 22, (734-741) DOI: 10.0121/tx800479s) Chemical Research in Toxicology. 25: 763. DOI: 10.1021/tx300048h  0.96
2012 Wang LS, Carmella S, Keyes R, Kuo CT, Huang YW, Hecht SS, Stoner GD. Anthocyanins and cancer prevention Nutraceuticals and Cancer. 2147483647: 201-229. DOI: 10.1007/978-94-007-2630-7_11  0.96
2011 Yuan JM, Gao YT, Murphy SE, Carmella SG, Wang R, Zhong Y, Moy KA, Davis AB, Tao L, Chen M, Han S, Nelson HH, Yu MC, Hecht SS. Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. Cancer Research. 71: 6749-57. PMID 22028322 DOI: 10.1158/0008-5472.CAN-11-0209  0.96
2011 Balbo S, Villalta PW, Hecht SS. Quantitation of 7-ethylguanine in leukocyte DNA from smokers and nonsmokers by liquid chromatography-nanoelectrospray-high resolution tandem mass spectrometry. Chemical Research in Toxicology. 24: 1729-34. PMID 21859140 DOI: 10.1021/tx200262d  0.96
2011 Vogel RI, Carmella SG, Stepanov I, Hatsukami DK, Hecht SS. The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 16: 491-7. PMID 21812592 DOI: 10.3109/1354750X.2011.598565  0.96
2011 Yuan JM, Knezevich AD, Wang R, Gao YT, Hecht SS, Stepanov I. Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. Carcinogenesis. 32: 1366-71. PMID 21734256 DOI: 10.1093/carcin/bgr125  0.96
2011 Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C. Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. The American Journal of Chinese Medicine. 39: 727-42. PMID 21721153 DOI: 10.1142/S0192415X11009202  0.96
2011 Hecht SS. More than 500 trillion molecules of strong carcinogens per cigarette: use in product labelling? Tobacco Control. 20: 387. PMID 21670075 DOI: 10.1136/tc.2011.042853  0.96
2011 Zhong Y, Wang J, Carmella SG, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami DK, Upadhyaya P, Zimmerman C, Hecht SS. Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration. The Journal of Pharmacology and Experimental Therapeutics. 338: 353-61. PMID 21515812 DOI: 10.1124/jpet.111.181719  0.96
2011 Hecht SS, Upadhyaya P, Wang M. Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes. Chemical Research in Toxicology. 24: 781-90. PMID 21480629 DOI: 10.1021/tx200064a  0.96
2011 Thomas JL, Guo H, Carmella SG, Balbo S, Han S, Davis A, Yoder A, Murphy SE, An LC, Ahluwalia JS, Hecht SS. Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 1213-21. PMID 21467230 DOI: 10.1158/1055-9965.EPI-10-1027  0.96
2011 Hecht SS. Perspective: Tackling the real issues. Nature. 471: S18. PMID 21430714 DOI: 10.1038/471S18a  0.96
2011 Hochalter JB, Zhong Y, Han S, Carmella SG, Hecht SS. Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene. Chemical Research in Toxicology. 24: 262-8. PMID 21229973 DOI: 10.1021/tx100391z  0.96
2011 Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE. Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 234-8. PMID 21212060 DOI: 10.1158/1055-9965.EPI-10-0674  0.96
2011 Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, Jensen J, Hatsukami D, Wang J, Zimmerman C, Hecht SS. Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. Chemical Research in Toxicology. 24: 246-52. PMID 21184614 DOI: 10.1021/tx100345x  0.96
2011 Zhang S, Balbo S, Wang M, Hecht SS. Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers. Chemical Research in Toxicology. 24: 119-24. PMID 21090699 DOI: 10.1021/tx100321y  0.96
2011 Kotlyar M, Hertsgaard LA, Lindgren BR, Jensen JA, Carmella SG, Stepanov I, Murphy SE, Hecht SS, Hatsukami DK. Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 91-100. PMID 21068204 DOI: 10.1158/1055-9965.EPI-10-0349  0.96
2011 Zhong Y, Carmella SG, Hochalter JB, Balbo S, Hecht SS. Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation. Chemical Research in Toxicology. 24: 73-80. PMID 21049951 DOI: 10.1021/tx100287n  0.96
2011 Hecht SS, Stepanov I, Hatsukami DK. Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products. Tobacco Control. 20: 443. PMID 20930058 DOI: 10.1136/tc.2010.037648  0.96
2011 Hecht SS. Tobacco smoke carcinogens and lung cancer Current Cancer Research. 6: 53-74. DOI: 10.1007/978-1-61737-995-6_3  0.96
2011 Smith RL, Waddell WJ, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Marnett LJ, Portoghese PS, Rietjens IMCM, Adams TB, Gavin CL, Mcgowen MM, Taylor SV. GRAS flavoring substances 25 Food Technology. 65: 44-75.  0.96
2010 Church TR, Haznadar M, Geisser MS, Anderson KE, Caporaso NE, Le C, Abdullah SB, Hecht SS, Oken MM, Van Ness B. Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk. International Journal of Molecular Epidemiology and Genetics. 1: 295-309. PMID 21532841  0.96
2010 Kassie F, Melkamu T, Endalew A, Upadhyaya P, Luo X, Hecht SS. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis. 31: 1634-41. PMID 20603442 DOI: 10.1093/carcin/bgq139  0.52
2010 Upadhyaya P, Hochalter JB, Balbo S, McIntee EJ, Hecht SS. Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1397-402. PMID 20547966 DOI: 10.1124/dmd.110.034181  0.52
2010 Cheng G, Wang M, Villalta PW, Hecht SS. Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA. Chemical Research in Toxicology. 23: 1089-96. PMID 20438065 DOI: 10.1021/tx100062v  0.76
2010 Hecht SS, Yuan JM, Hatsukami D. Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. Chemical Research in Toxicology. 23: 1001-8. PMID 20408564 DOI: 10.1021/tx100056m  0.32
2010 Hecht SS, Seow A, Wang M, Wang R, Meng L, Koh WP, Carmella SG, Chen M, Han S, Yu MC, Yuan JM. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1185-92. PMID 20406956 DOI: 10.1158/1055-9965.EPI-09-1291  0.76
2010 Church TR, Anderson KE, Le C, Zhang Y, Kampa DM, Benoit AR, Yoder AR, Carmella SG, Hecht SS. Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 15: 345-52. PMID 20374068 DOI: 10.3109/13547501003753881  0.96
2010 Hecht SS, Carmella SG, Villalta PW, Hochalter JB. Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies. Chemical Research in Toxicology. 23: 900-8. PMID 20369855 DOI: 10.1021/tx9004538  0.76
2010 Jensen JA, Schillo BA, Moilanen MM, Lindgren BR, Murphy S, Carmella S, Hecht SS, Hatsukami DK. Tobacco smoke exposure in nonsmoking hospitality workers before and after a state smoking ban. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1016-21. PMID 20354127 DOI: 10.1158/1055-9965.EPI-09-0969  0.76
2010 Maertens LA, Upadhyaya P, Hecht SS, Zimmerman CL. Formation and distribution of NNK metabolites in an isolated perfused rat lung. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 752-60. PMID 20159989 DOI: 10.1124/dmd.109.031492  0.52
2010 Thomas JL, An L, Luo X, Scherber RM, Berg CJ, Golden D, Ehlinger EP, Murphy SE, Hecht SS, Ahluwalia JS. Abstinence and relapse rates following a college campus-based quit & win contest. Journal of American College Health : J of Ach. 58: 365-72. PMID 20159760 DOI: 10.1080/07448480903380268  0.96
2010 Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner G. Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. Journal of Agricultural and Food Chemistry. 58: 3992-5. PMID 20121200 DOI: 10.1021/jf9030635  0.96
2010 Hatsukami DK, Kotlyar M, Hertsgaard LA, Zhang Y, Carmella SG, Jensen JA, Allen SS, Shields PG, Murphy SE, Stepanov I, Hecht SS. Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction (Abingdon, England). 105: 343-55. PMID 20078491 DOI: 10.1111/j.1360-0443.2009.02780.x  0.96
2010 Stepanov I, Villalta PW, Knezevich A, Jensen J, Hatsukami D, Hecht SS. Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry. Chemical Research in Toxicology. 23: 66-73. PMID 19860436 DOI: 10.1021/tx100071r  0.76
2010 Zhang L, Freeman LE, Nakamura J, Hecht SS, Vandenberg JJ, Smith MT, Sonawane BR. Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment. Environmental and Molecular Mutagenesis. 51: 181-91. PMID 19790261 DOI: 10.1002/em.20534  0.96
2010 Kassie F, Kalscheuer S, Matise I, Ma L, Melkamu T, Upadhyaya P, Hecht SS. Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. Carcinogenesis. 31: 239-45. PMID 19625346 DOI: 10.1093/carcin/bgp174  0.96
2010 Hecht SS. Tobacco carcinogenesis: Mechanisms and biomarkers Tobacco: Science, Policy and Public Health. DOI: 10.1093/acprof:oso/9780199566655.003.0007  0.96
2009 Kim YY, Von Weymarn L, Larsson O, Fan D, Underwood JM, Peterson MS, Hecht SS, Polunovsky VA, Bitterman PB. Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense. Cancer Research. 69: 8455-62. PMID 19843855 DOI: 10.1158/0008-5472.CAN-09-1923  0.96
2009 Stepanov I, Carmella SG, Briggs A, Hertsgaard L, Lindgren B, Hatsukami D, Hecht SS. Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. Cancer Research. 69: 8236-40. PMID 19843845 DOI: 10.1158/0008-5472.CAN-09-1084  0.48
2009 Loureiro AP, Zhang W, Kassie F, Zhang S, Villalta PW, Wang M, Hecht SS. Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA. Chemical Research in Toxicology. 22: 1728-35. PMID 19761253 DOI: 10.1021/tx900238t  0.96
2009 Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS. Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. Cancer Research. 69: 7170-4. PMID 19738046 DOI: 10.1158/0008-5472.CAN-09-1571  0.76
2009 Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA. The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chemical Research in Toxicology. 22: 1464-72. PMID 19601657 DOI: 10.1021/tx9001572  0.96
2009 Derby KS, Cuthrell K, Caberto C, Carmella S, Murphy SE, Hecht SS, Le Marchand L. Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. International Journal of Cancer. Journal International Du Cancer. 125: 2418-24. PMID 19598261 DOI: 10.1002/ijc.24585  0.96
2009 Hecht SS, Kassie F, Hatsukami DK. Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers. Nature Reviews. Cancer. 9: 476-88. PMID 19550424 DOI: 10.1038/nrc2674  0.48
2009 Zhang S, Wang M, Villalta PW, Lindgren BR, Lao Y, Hecht SS. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical Research in Toxicology. 22: 949-56. PMID 19405515 DOI: 10.1021/tx900040j  0.96
2009 Zhang S, Wang M, Villalta PW, Lindgren BR, Upadhyaya P, Lao Y, Hecht SS. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 22: 926-36. PMID 19358518 DOI: 10.1021/tx900015d  0.96
2009 Upadhyaya P, Lindgren BR, Hecht SS. Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1147-51. PMID 19324941 DOI: 10.1124/dmd.109.027078  0.96
2009 Yuan JM, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, Han S, Wickham K, Gao YT, Yu MC, Hecht SS. Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Research. 69: 2990-5. PMID 19318550 DOI: 10.1158/0008-5472.CAN-08-4330  0.56
2009 Carmella SG, Chen M, Han S, Briggs A, Jensen J, Hatsukami DK, Hecht SS. Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. Chemical Research in Toxicology. 22: 734-41. PMID 19317515 DOI: 10.1021/tx800479s  0.48
2009 Stepanov I, Carmella SG, Han S, Pinto A, Strasser AA, Lerman C, Hecht SS. Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 11: 99-105. PMID 19246447 DOI: 10.1093/ntr/ntn004  0.48
2009 Hecht SS, Berg JZ, Hochalter JB. Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer. Chemical Research in Toxicology. 22: 426-32. PMID 19187038 DOI: 10.1021/tx800315m  0.48
2009 Stepanov I, Hecht SS. Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 22: 406-14. PMID 19166332 DOI: 10.1021/tx800398x  0.32
2009 Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prevention Research (Philadelphia, Pa.). 2: 84-93. PMID 19139022 DOI: 10.1158/1940-6207.CAPR-08-0155  0.96
2009 Church TR, Anderson KE, Caporaso NE, Geisser MS, Le CT, Zhang Y, Benoit AR, Carmella SG, Hecht SS. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 260-6. PMID 19124507 DOI: 10.1158/1055-9965.EPI-08-0718  0.96
2008 Kassie F, Matise I, Negia M, Upadhyaya P, Hecht SS. Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. Cancer Prevention Research (Philadelphia, Pa.). 1: 568-76. PMID 19139007 DOI: 10.1158/1940-6207.CAPR-08-0064  0.96
2008 Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, Upadhyaya P, Ruvolo PP, Hecht SS, Xing C. Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 430-8. PMID 19138990 DOI: 10.1158/1940-6207.CAPR-08-0027  0.96
2008 Kassie F, Matise I, Negia M, Lahti D, Pan Y, Scherber R, Upadhyaya P, Hecht SS. Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 285-97. PMID 19138972 DOI: 10.1158/1940-6207.CAPR-08-0012  0.96
2008 Hertsgaard LA, Hanson K, Hecht SS, Lindgren BR, Luo X, Carmella SG, Riley WT, Zylla EB, Murphy SE, Hatsukami DK. Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3337-43. PMID 19064548 DOI: 10.1158/1055-9965.EPI-08-0307  0.96
2008 Derby KS, Cuthrell K, Caberto C, Carmella SG, Franke AA, Hecht SS, Murphy SE, Le Marchand L. Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3526-35. PMID 19029401 DOI: 10.1158/1055-9965.EPI-08-0424  0.96
2008 Stepanov I, Jensen J, Hatsukami D, Hecht SS. New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 1773-82. PMID 19023828 DOI: 10.1080/14622200802443544  0.36
2008 Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Research. 68: 9137-40. PMID 19010884 DOI: 10.1158/0008-5472.CAN-08-2271  0.96
2008 Balbo S, Hashibe M, Gundy S, Brennan P, Canova C, Simonato L, Merletti F, Richiardi L, Agudo A, Castellsagué X, Znaor A, Talamini R, Bencko V, Holcátová I, Wang M, ... Hecht SS, et al. N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNA. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3026-32. PMID 18990745 DOI: 10.1158/1055-9965.EPI-08-0117  0.76
2008 Stepanov I, Upadhyaya P, Carmella SG, Feuer R, Jensen J, Hatsukami DK, Hecht SS. Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 1764-73. PMID 18628430 DOI: 10.1158/1055-9965.EPI-07-2844  0.52
2008 Boffetta P, Hecht S, Gray N, Gupta P, Straif K. Smokeless tobacco and cancer The Lancet Oncology. 9: 667-675. PMID 18598931 DOI: 10.1016/S1470-2045(08)70173-6  0.96
2008 Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 21: 1468-76. PMID 18570389 DOI: 10.1021/tx8001109  0.76
2008 Hecht SS, Carmella SG, Edmonds A, Murphy SE, Stepanov I, Luo X, Hatsukami DK. Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco. Tobacco Control. 17: 128-31. PMID 18375734 DOI: 10.1136/tc.2007.023242  0.96
2008 Hecht SS, Carmella SG, Stepanov I, Jensen J, Anderson A, Hatsukami DK. Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 732-5. PMID 18349296 DOI: 10.1158/1055-9965.EPI-07-2843  0.48
2008 Joseph AM, Hecht SS, Murphy SE, Lando H, Carmella SG, Gross M, Bliss R, Le CT, Hatsukami DK. Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 471-81. PMID 18324566 DOI: 10.1080/14622200801901948  0.96
2008 Cheng G, Wang M, Upadhyaya P, Villalta PW, Hecht SS. Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA). Chemical Research in Toxicology. 21: 746-51. PMID 18205321 DOI: 10.1021/tx7003823  0.76
2008 Kassie F, Anderson LB, Higgins L, Pan Y, Matise I, Negia M, Upadhyaya P, Wang M, Hecht SS. Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. Carcinogenesis. 29: 610-9. PMID 18192687 DOI: 10.1093/carcin/bgn014  0.96
2008 Hatsukami DK, Ebbert JO, Edmonds A, Li C, Lin H, Le C, Hecht SS. Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 77-85. PMID 18188748 DOI: 10.1080/14622200701704897  0.96
2008 Mendoza-Baumgart MI, Tulunay OE, Hecht SS, Zhang Y, Murphy S, Le C, Jensen J, Hatsukami DK. Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: 1309-23. PMID 18058349 DOI: 10.1080/14622200701704228  0.4
2008 Hecht SS. Progress and challenges in selected areas of tobacco carcinogenesis Chemical Research in Toxicology. 21: 160-171. PMID 18052103 DOI: 10.1021/tx7002068  0.96
2008 Liu X, Moody EC, Hecht SS, Sturla SJ. Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity. Bioorganic & Medicinal Chemistry. 16: 3419-27. PMID 17981044 DOI: 10.1016/j.bmc.2007.10.032  0.96
2008 Hecht SS. Carcinogen Metabolites as Biomarkers Molecular Epidemiology of Chronic Diseases. 97-110. DOI: 10.1002/9780470725726.ch8  0.96
2007 Hatsukami DK, Joseph AM, Lesage M, Jensen J, Murphy SE, Pentel PR, Kotlyar M, Borgida E, Le C, Hecht SS. Developing the science base for reducing tobacco harm. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: S537-53. PMID 18067031 DOI: 10.1080/14622200701679040  0.96
2007 Spector LG, Hecht SS, Ognjanovic S, Carmella SG, Ross JA. Detection of cotinine in newborn dried blood spots. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1902-5. PMID 17855712 DOI: 10.1158/1055-9965.EPI-07-0230  0.96
2007 Lubin JH, Caporaso N, Hatsukami DK, Joseph AM, Hecht SS. The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1852-7. PMID 17855705 DOI: 10.1158/1055-9965.EPI-07-0018  0.96
2007 Hecht SS, Carmella SG, Murphy SE, Riley WT, Le C, Luo X, Mooney M, Hatsukami DK. Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1567-72. PMID 17684130 DOI: 10.1158/1055-9965.EPI-07-0227  0.96
2007 Wang M, Cheng G, Villalta PW, Hecht SS. Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology. 20: 1141-8. PMID 17676814 DOI: 10.1021/tx700189c  0.76
2007 Porubin D, Hecht SS, Li ZZ, Gonta M, Stepanov I. Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract. Journal of Agricultural and Food Chemistry. 55: 7199-204. PMID 17637060 DOI: 10.1021/jf0712191  0.6
2007 Stepanov I, Hecht SS, Lindgren B, Jacob P, Wilson M, Benowitz NL. Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1382-6. PMID 17627002 DOI: 10.1158/1055-9965.EPI-07-0145  0.4
2007 Kassie F, Anderson LB, Scherber R, Yu N, Lahti D, Upadhyaya P, Hecht SS. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. Cancer Research. 67: 6502-11. PMID 17616712 DOI: 10.1158/0008-5472.CAN-06-4438  0.96
2007 Stark MJ, Rohde K, Maher JE, Pizacani BA, Dent CW, Bard R, Carmella SG, Benoit AR, Thomson NM, Hecht SS. The impact of clean indoor air exemptions and preemption policies on the prevalence of a tobacco-specific lung carcinogen among nonsmoking bar and restaurant workers. American Journal of Public Health. 97: 1457-63. PMID 17600262 DOI: 10.2105/AJPH.2006.094086  0.96
2007 Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF. Cancer prevention with freeze-dried berries and berry components. Seminars in Cancer Biology. 17: 403-10. PMID 17574861 DOI: 10.1016/j.semcancer.2007.05.001  0.96
2007 Carmella SG, Chen M, Zhang Y, Zhang S, Hatsukami DK, Hecht SS. Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking. Chemical Research in Toxicology. 20: 986-90. PMID 17559234 DOI: 10.1021/tx700075y  0.96
2007 McNiel EA, Carmella SG, Heath LA, Bliss RL, Le KA, Hecht SS. Urinary biomarkers to assess exposure of cats to environmental tobacco smoke. American Journal of Veterinary Research. 68: 349-53. PMID 17397288 DOI: 10.2460/ajvr.68.4.349  0.96
2007 Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Nishikawa A, Hecht SS. Analysis of adducts in hepatic DNA of rats treated with N-nitrosopyrrolidine. Chemical Research in Toxicology. 20: 634-40. PMID 17394361 DOI: 10.1021/tx600333e  0.96
2007 Wang M, Lao Y, Cheng G, Shi Y, Villalta PW, Hecht SS. Identification of adducts formed in the reaction of alpha-acetoxy-N-nitrosopyrrolidine with deoxyribonucleosides and DNA. Chemical Research in Toxicology. 20: 625-33. PMID 17394360 DOI: 10.1021/tx600332p  0.96
2007 Zhang S, Villalta PW, Wang M, Hecht SS. Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 20: 565-71. PMID 17385896 DOI: 10.1021/tx700023z  0.96
2007 Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS. Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine. Chemical Research in Toxicology. 20: 246-56. PMID 17305408 DOI: 10.1021/tx060208j  0.96
2007 Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology. 20: 235-45. PMID 17305407 DOI: 10.1021/tx060207r  0.96
2007 Hecht SS, Han S, Kenney PM, Wang M, Lindgren B, Wang Y, Lao Y, Hochalter JB, Upadhyaya P. Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chemical Research in Toxicology. 20: 543-9. PMID 17291014 DOI: 10.1021/tx600328e  0.96
2007 Hatsukami D, Mooney M, Murphy S, LeSage M, Babb D, Hecht S. Effects of high dose transdermal nicotine replacement in cigarette smokers Pharmacology Biochemistry and Behavior. 86: 132-139. PMID 17267026 DOI: 10.1016/j.pbb.2006.12.017  0.96
2007 Chen L, Wang M, Villalta PW, Luo X, Feuer R, Jensen J, Hatsukami DK, Hecht SS. Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation. Chemical Research in Toxicology. 20: 108-13. PMID 17226933 DOI: 10.1021/tx060232x  0.76
2006 Hatsukami DK, Le CT, Zhang Y, Joseph AM, Mooney ME, Carmella SG, Hecht SS. Toxicant exposure in cigarette reducers versus light smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 2355-8. PMID 17164356 DOI: 10.1158/1055-9965.EPI-06-0240  0.96
2006 Hecht SS. Smoking and lung cancer - A new role for an old toxicant? Proceedings of the National Academy of Sciences of the United States of America. 103: 15725-15726. PMID 17043212 DOI: 10.1073/pnas.0607811103  0.96
2006 Liu X, Lao Y, Yang IY, Hecht SS, Moriya M. Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity. Biochemistry. 45: 12898-905. PMID 17042508 DOI: 10.1021/bi060792v  0.96
2006 Zhang S, Villalta PW, Wang M, Hecht SS. Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology. 19: 1386-92. PMID 17040109 DOI: 10.1021/tx060154d  0.96
2006 Hecht SS, Carmella SG, Yoder A, Chen M, Li ZZ, Le C, Dayton R, Jensen J, Hatsukami DK. Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1805-11. PMID 17035385 DOI: 10.1158/1055-9965.EPI-06-0173  0.48
2006 Hecht SS. Cigarette smoking: Cancer risks, carcinogens, and mechanisms Langenbeck's Archives of Surgery. 391: 603-613. PMID 17031696 DOI: 10.1007/s00423-006-0111-z  0.96
2006 Hecht SS. A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer Preventive Medicine. 43: 256-260. PMID 16997360 DOI: 10.1016/j.ypmed.2006.07.020  0.96
2006 Upadhyaya P, Rao P, Hochalter JB, Li ZZ, Villalta PW, Hecht SS. Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers. Chemical Research in Toxicology. 19: 1234-40. PMID 16978029 DOI: 10.1021/tx060096w  0.76
2006 Carmella SG, Yoder A, Hecht SS. Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1490-4. PMID 16896038 DOI: 10.1158/1055-9965.EPI-06-0199  0.48
2006 Stein S, Lao Y, Yang IY, Hecht SS, Moriya M. Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. Mutation Research. 608: 1-7. PMID 16797223 DOI: 10.1016/j.mrgentox.2006.01.009  0.96
2006 Hecht SS. Re: Foulds and Ramstrom: Cancer Causes and Control 17: 227-228 (2006) and Henley et al., Cancer Causes and Control 16: 347-358 (2005). How smokeless tobacco can cause lung cancer [2] Cancer Causes and Control. 17: 859-860. PMID 16783615 DOI: 10.1007/s10552-006-0021-y  0.96
2006 Hecht SS, Carmella SG, Le KA, Murphy SE, Boettcher AJ, Le C, Koopmeiners J, An L, Hennrikus DJ. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 988-92. PMID 16702381 DOI: 10.1158/1055-9965.EPI-05-0596  0.96
2006 Lao Y, Villalta PW, Sturla SJ, Wang M, Hecht SS. Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology. 19: 674-82. PMID 16696570 DOI: 10.1021/tx050351x  0.96
2006 Upadhyaya P, McIntee EJ, Villalta PW, Hecht SS. Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA. Chemical Research in Toxicology. 19: 426-35. PMID 16544948 DOI: 10.1021/tx050323e  0.96
2006 Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis. 27: 1617-26. PMID 16522666 DOI: 10.1093/carcin/bgi366  0.96
2006 Stepanov I, Hecht SS, Duca G, Mardari I. Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 7-11. PMID 16434579 DOI: 10.1158/1055-9965.EPI-05-0293  0.32
2006 Wang JK, Khonsari MM. Influence of inlet oil temperature on the instability threshold of rotor-bearing systems Journal of Tribology. 128: 319-326. DOI: 10.1021/tx0502948  0.48
2005 Hecht SS, Chen M, Yoder A, Jensen J, Hatsukami D, Le C, Carmella SG. Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2969-74. PMID 16365018 DOI: 10.1158/1055-9965.EPI-05-0396  0.48
2005 Joseph AM, Hecht SS, Murphy SE, Carmella SG, Le CT, Zhang Y, Han S, Hatsukami DK. Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2963-8. PMID 16365017 DOI: 10.1158/1055-9965.EPI-04-0768  0.96
2005 Hecht SS. Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens Journal of the National Cancer Institute. 97: 1634-1635. PMID 16288111 DOI: 10.1093/jnci/dji414  0.96
2005 Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, ... ... Hecht SS, et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2605-13. PMID 16284385 DOI: 10.1158/1055-9965.EPI-05-0368  0.96
2005 Stepanov I, Hecht SS, Mirvish SS, Gonta M. Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco. Journal of Agricultural and Food Chemistry. 53: 8082-6. PMID 16190674 DOI: 10.1021/jf050747e  0.32
2005 Conaway CC, Wang CX, Pittman B, Yang YM, Schwartz JE, Tian D, McIntee EJ, Hecht SS, Chung FL. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Research. 65: 8548-57. PMID 16166336 DOI: 10.1158/0008-5472.CAN-05-0237  0.44
2005 Lemmonds CA, Hecht SS, Jensen JA, Murphy SE, Carmella SG, Zhang Y, Hatsukami DK. Smokeless tobacco topography and toxin exposure. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 7: 469-74. PMID 16085515 DOI: 10.1080/14622200500135640  0.96
2005 Sturla SJ, Scott J, Lao Y, Hecht SS, Villalta PW. Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology. 18: 1048-55. PMID 15962940 DOI: 10.1021/tx050028u  0.96
2005 Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes. Chemical Research in Toxicology. 18: 913-8. PMID 15962925 DOI: 10.1021/tx0500777  0.96
2005 Hecht SS. Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: Old and new Carcinogenesis. 26: 1488-1492. PMID 15930027 DOI: 10.1093/carcin/bgi148  0.96
2005 Tulunay OE, Hecht SS, Carmella SG, Zhang Y, Lemmonds C, Murphy S, Hatsukami DK. Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers Cancer Epidemiology Biomarkers and Prevention. 14: 1283-1286. PMID 15894687 DOI: 10.1158/1055-9965.EPI-04-0570  0.96
2005 Lao Y, Hecht SS. Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link. Chemical Research in Toxicology. 18: 711-21. PMID 15833031 DOI: 10.1021/tx0497292  0.96
2005 Kelley MJ, Glaser EM, Herndon JE, Becker F, Bhagat R, Zhang YJ, Santella RM, Carmella SG, Hecht SS, Gallot L, Schilder L, Crowell JA, Perloff M, Folz RJ, Bergan RC. Safety and efficacy of weekly oral oltipraz in chronic smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 892-9. PMID 15824161 DOI: 10.1158/1055-9965.EPI-04-0585  0.96
2005 Hecht SS, Murphy SE, Carmella SG, Li S, Jensen J, Le C, Joseph AM, Hatsukami DK. Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 693-8. PMID 15767351 DOI: 10.1158/1055-9965.EPI-04-0542  0.96
2005 Kim JY, Hecht SS, Mukherjee S, Carmella SG, Rodrigues EG, Christiani DC. A urinary metabolite of phenanthrene as a biomarker of polycyclic aromatic hydrocarbon metabolic activation in workers exposed to residual oil fly ash. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 687-92. PMID 15767350 DOI: 10.1158/1055-9965.EPI-04-0428  0.48
2005 Jalas JR, Hecht SS, Murphy SE. Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. Chemical Research in Toxicology. 18: 95-110. PMID 15720112 DOI: 10.1021/tx049847p  0.96
2005 Wong HL, Murphy SE, Hecht SS. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chemical Research in Toxicology. 18: 61-9. PMID 15651850 DOI: 10.1021/tx0497696  0.96
2004 Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Seminars in Cancer Biology. 14: 473-86. PMID 15489140 DOI: 10.1016/j.semcancer.2004.06.010  0.96
2004 Jalas JR, Seetharaman M, Hecht SS, Murphy SE. Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 34: 515-33. PMID 15277013 DOI: 10.1080/00498250410001713131  0.96
2004 Hughes JR, Hecht SS, Carmella SG, Murphy SE, Callas P. Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni. Tobacco Control. 13: 175-9. PMID 15175536 DOI: 10.1136/tc.2003.005439  0.96
2004 Hatsukami DK, Lemmonds C, Zhang Y, Murphy SE, Le C, Carmella SG, Hecht SS. Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. Journal of the National Cancer Institute. 96: 844-52. PMID 15173268 DOI: 10.1093/jnci/djh163  0.96
2004 Hecht SS, Villalta PW, Sturla SJ, Cheng G, Yu N, Upadhyaya P, Wang M. Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA. Chemical Research in Toxicology. 17: 588-97. PMID 15144215 DOI: 10.1021/tx034263t  0.96
2004 Sexton K, Adgate JL, Church TR, Hecht SS, Ramachandran G, Greaves IA, Fredrickson AL, Ryan AD, Carmella SG, Geisser MS. Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences. Environmental Health Perspectives. 112: 392-7. PMID 14998759 DOI: 10.1289/ehp.6473  0.96
2004 Zimmerman CL, Wu Z, Upadhyaya P, Hecht SS. Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis. 25: 1237-42. PMID 14988218 DOI: 10.1093/carcin/bgh120  0.52
2004 Hecht SS. Carcinogen derived biomarkers: Applications in studies of human exposure to secondhand tobacco smoke Tobacco Control. 13. PMID 14985617 DOI: 10.1136/tc.2002.002816  0.96
2004 Hecht SS, Murphy SE, Carmella SG, Zimmerman CL, Losey L, Kramarczuk I, Roe MR, Puumala SS, Li YS, Le C, Jensen J, Hatsukami DK. Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen. Journal of the National Cancer Institute. 96: 107-15. PMID 14734700 DOI: 10.1093/jnci/djh016  0.96
2004 Henn SA, Succop P, Talaska G, Anderson K, Hecht SS, Gross M. Carcinogen-DNA adducts are increased in the exfoliated urothelial cells of wives of smokers: Biological monitoring of passive smoke exposure Polycyclic Aromatic Compounds. 24: 475-485. DOI: 10.1080/10406630490471492  0.96
2003 Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer Nature Reviews Cancer. 3: 733-744. PMID 14570033 DOI: 10.1038/nrc1190  0.96
2003 Wong HL, Murphy SE, Hecht SS. Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes. Chemical Research in Toxicology. 16: 1298-305. PMID 14565771 DOI: 10.1021/tx0340495  0.96
2003 Jalas JR, McIntee EJ, Kenney PM, Upadhyaya P, Peterson LA, Hecht SS. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology. 16: 794-806. PMID 12807363 DOI: 10.1021/tx034022l  0.96
2003 Jalas JR, Hecht SS. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5. Chemical Research in Toxicology. 16: 782-93. PMID 12807362 DOI: 10.1021/tx034021t  0.96
2003 Hatsukami DK, Hecht SS, Hennrikus DJ, Joseph AM, Pentel PR. Biomakers of tobacco exposure or harm: Application to clinical and epidemiological studies Nicotine and Tobacco Research. 5: 387-396. PMID 12791522 DOI: 10.1080/1462220031000094222  0.96
2003 Wang M, Cheng G, Sturla SJ, Shi Y, McIntee EJ, Villalta PW, Upadhyaya P, Hecht SS. Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. Chemical Research in Toxicology. 16: 616-26. PMID 12755591 DOI: 10.1021/tx034003b  0.96
2003 Hatsukami DK, Edmonds A, Schulte S, Jensen J, Le CT, Losey L, Carmella SG, Hecht SS. Preliminary study on reducing oral moist snuff use. Drug and Alcohol Dependence. 70: 215-20. PMID 12732415 DOI: 10.1016/S0376-8716(03)00006-1  0.96
2003 Boysen G, Kenney PM, Upadhyaya P, Wang M, Hecht SS. Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis. 24: 517-25. PMID 12663513 DOI: 10.1093/carcin/24.3.517  0.76
2003 Upadhyaya P, Sturla SJ, Tretyakova N, Ziegel R, Villalta PW, Wang M, Hecht SS. Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chemical Research in Toxicology. 16: 180-90. PMID 12588189 DOI: 10.1021/tx0256376  0.96
2003 Cheng G, Shi Y, Sturla SJ, Jalas JR, McIntee EJ, Villalta PW, Wang M, Hecht SS. Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chemical Research in Toxicology. 16: 145-52. PMID 12588185 DOI: 10.1021/tx025614r  0.96
2003 Wong HL, Murphy SE, Wang M, Hecht SS. Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3. Carcinogenesis. 24: 291-300. PMID 12584180 DOI: 10.1093/carcin/24.2.291  0.96
2002 Hecht SS, Kenney PM, Wang M, Upadhyaya P. Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. Cancer Letters. 187: 87-94. PMID 12359355 DOI: 10.1016/S0304-3835(02)00410-X  0.96
2002 Upadhyaya P, Zimmerman CL, Hecht SS. Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1115-22. PMID 12228188 DOI: 10.1124/dmd.30.10.1115  0.96
2002 Hecht SS, Upadhyaya P, Wang M, Bliss RL, McIntee EJ, Kenney PM. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis. 23: 1455-61. PMID 12189187 DOI: 10.1093/carcin/23.9.1455  0.76
2002 Sticha KR, Kenney PM, Boysen G, Liang H, Su X, Wang M, Upadhyaya P, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis. 23: 1433-9. PMID 12189184 DOI: 10.1093/carcin/23.9.1433  0.76
2002 Hecht SS. Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention Lancet Oncology. 3: 461-469. PMID 12147432 DOI: 10.1016/S1470-2045(02)00815-X  0.96
2002 Hecht SS. Human urinary carcinogen metabolites: Biomarkers for investigating tobacco and cancer Carcinogenesis. 23: 907-922. PMID 12082012 DOI: 10.1093/carcin/23.6.907  0.96
2002 Hecht SS. Tobacco smoke carcinogens and breast cancer Environmental and Molecular Mutagenesis. 39: 119-126. PMID 11921179 DOI: 10.1002/em.10071  0.96
2002 Wu Z, Upadhyaya P, Carmella SG, Hecht SS, Zimmerman CL. Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution. Carcinogenesis. 23: 171-9. PMID 11756238 DOI: 10.1093/carcin/23.1.171  0.52
2001 Gurney JG, Smith MA, Olshan AF, Hecht SS, Kasum CM. Clues to the etiology of childhood brain cancer: N-nitroso compounds, polyomaviruses, and other factors of interest Cancer Investigation. 19: 630-640. PMID 11486706 DOI: 10.1081/CNV-100104291  0.96
2001 Baum M, Amin S, Guengerich FP, Hecht SS, Köhl W, Eisenbrand G. Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. Chemical Research in Toxicology. 14: 686-93. PMID 11409939 DOI: 10.1021/tx000240s  0.44
2001 Liebes L, Conaway CC, Hochster H, Mendoza S, Hecht SS, Crowell J, Chung FL. High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Analytical Biochemistry. 291: 279-89. PMID 11401302 DOI: 10.1006/abio.2001.5030  0.44
2001 Leslie EM, Ito KI, Upadhyaya P, Hecht SS, Deeley RG, Cole SPC. Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1): Requirement for glutathione or a non-sulfur-containing analog Journal of Biological Chemistry. 276: 27846-27854. PMID 11375986 DOI: 10.1074/jbc.M102453200  0.96
2001 Upadhyaya P, McIntee EJ, Hecht SS. Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines Chemical Research in Toxicology. 14: 555-561. PMID 11368554 DOI: 10.1021/tx000262e  0.96
2001 Hecht SS, Kenney PMJ, Wang M, Upadhyaya P. Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Cancer Letters. 167: 1-6. PMID 11323092 DOI: 10.1016/S0304-3835(01)00454-2  0.96
2001 Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS. A Schiff base is a major DNA adduct of crotonaldehyde. Chemical Research in Toxicology. 14: 423-30. PMID 11304131 DOI: 10.1021/tx000234w  0.32
2000 Hecht SS. Inhibition of carcinogenesis by isothiocyanates Drug Metabolism Reviews. 32: 395-411. PMID 11139137 DOI: 10.1081/DMR-100102342  0.96
2000 Hecht SS, Hoffmann D. Re: Cigar smoking in men and risk of death from tobacco-related cancers. Journal of the National Cancer Institute. 92: 2040. PMID 11121469  0.88
2000 Hecht SS, Hochalter BJ, Villalta PW, Murphy SE. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor Proceedings of the National Academy of Sciences of the United States of America. 97: 12493-12497. PMID 11050152 DOI: 10.1073/pnas.220207697  0.96
2000 Hecht SS. Metabolically activated carcinogens and mutations in the p53 tumor suppressor gene in lung cancer Journal of the National Cancer Institute. 92: 782-783. PMID 10814664 DOI: 10.1093/jnci/92.10.782  0.96
1999 Hecht SS, Kenney PM, Wang M, Trushin N, Agarwal S, Rao AV, Upadhyaya P. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Letters. 137: 123-30. PMID 10374832 DOI: 10.1016/S0304-3835(98)00326-7  0.76
1999 Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism Journal of Nutrition. 129. PMID 10082787 DOI: 10.1093/jn/129.3.768S  0.96
1999 Lackmann GM, Salzberger U, Töllner U, Chen M, Carmella SG, Hecht SS. Metabolites of a tobacco-specific carcinogen in urine from newborns. Journal of the National Cancer Institute. 91: 459-65. PMID 10070946 DOI: 10.1093/jnci/91.5.459  0.96
1999 Hecht SS. DNA adduct formation from tobacco-specific N-nitrosamines Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 424: 127-142. PMID 10064856 DOI: 10.1016/S0027-5107(99)00014-7  0.96
1999 Jyonouchi H, Sun S, Iijima K, Wang M, Hecht SS. Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. Carcinogenesis. 20: 139-45. PMID 9934861 DOI: 10.1093/carcin/20.1.139  0.44
1999 Lackmann GM, Salzberger U, Chen M, Carmella SG, Töllner U, Hecht SS. Tobacco-specific transplacental carcinogens, nicotine, and cotinine in the urine of newborns of smoking mothers Monatsschrift Fur Kinderheilkunde. 147: 333-338. DOI: 10.1007/s001120050431  0.96
1998 Stoner GD, Adams C, Kresty LA, Amin SG, Desai D, Hecht SS, Murphy SE, Morsc MA. Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate Carcinogenesis. 19: 2139-2143. PMID 9886569 DOI: 10.1093/carcin/19.12.2139  0.96
1998 Wang M, Upadhyaya P, Dinh TT, Bonilla LE, Hecht SS. Lactols in hydrolysates of DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or crotonaldehyde. Chemical Research in Toxicology. 11: 1567-73. PMID 9860502 DOI: 10.1021/tx980165  0.76
1998 Hecht SS, Hoffmann D. N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 7: 165-6. PMID 9818780  0.96
1998 Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N- nitrosamines Chemical Research in Toxicology. 11: 559-603. PMID 9625726 DOI: 10.1021/tx980005y  0.96
1997 Hecht SS. Tobacco and cancer: Approaches using carcinogen biomarkers and chemoprevention Annals of the New York Academy of Sciences. 833: 91-111. PMID 9616743 DOI: 10.1111/j.1749-6632.1997.tb48596.x  0.96
1997 Cinciripini PM, Hecht SS, Henningfield JE, Manley MW, Kramer BS. Tobacco addiction: Implications for treatment and cancer prevention Journal of the National Cancer Institute. 89: 1852-1867. PMID 9414173  0.96
1997 Hecht SS. Approaches to cancer prevention based on an understanding of N- nitrosamine carcinogenesis Proceedings of the Society For Experimental Biology and Medicine. 216: 181-191. PMID 9349687 DOI: 10.3181/00379727-216-44168  0.96
1997 Chen LJ, Hecht SS, Peterson LA. Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chemical Research in Toxicology. 10: 866-74. PMID 9282835 DOI: 10.1021/tx9700174  0.96
1997 Hecht SS. Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke Environmental Health Perspectives. 105: 955-963. PMID 9255587 DOI: 10.1289/ehp.97105s4955  0.96
1997 Wang L, Spratt TE, Liu XK, Hecht SS, Pegg AE, Peterson LA. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology. 10: 562-7. PMID 9168254 DOI: 10.1021/tx9602067  0.96
1996 Hecht SS. Chemoprevention of lung cancer by isothiocyanates Advances in Experimental Medicine and Biology. 401: 1-11. PMID 8886122 DOI: 10.1007/978-1-4613-0399-2_1  0.96
1996 Hecht SS. Carcinogen-derived biomarkers and lung cancer Preventive Medicine. 25: 7-9. PMID 8778771 DOI: 10.1006/pmed.1996.0004  0.96
1996 Hoffmann D, Rivenson A, Hecht SS. The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung. Critical Reviews in Toxicology. 26: 199-211. PMID 8688161 DOI: 10.3109/10408449609017931  0.88
1996 Hecht SS. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen Critical Reviews in Toxicology. 26: 163-181. PMID 8688159 DOI: 10.3109/10408449609017929  0.96
1996 Amin S, Desai D, Hecht SS, Hoffmann D. Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays. Critical Reviews in Toxicology. 26: 139-47. PMID 8688157 DOI: 10.3109/10408449609017927  0.88
1995 Chen LJ, Hecht SS, Peterson LA. Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan. Chemical Research in Toxicology. 8: 903-6. PMID 8555403 DOI: 10.1021/tx00049a001  0.96
1995 Hecht SS. Chemoprevention by isothiocyanates Journal of Cellular Biochemistry. 58: 195-209. PMID 8538199 DOI: 10.1002/jcb.240590825  0.96
1995 Amin S, Desai D, Dai W, Harvey RG, Hecht SS. Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene. Carcinogenesis. 16: 2813-7. PMID 7586203 DOI: 10.1093/carcin/16.11.2813  0.96
1994 Hecht SS. Metabolic activation and detoxification of tobacco-specific nitrosamines-a model for cancer prevention strategies Drug Metabolism Reviews. 26: 373-390. PMID 8082576 DOI: 10.3109/03602539409029803  0.96
1994 Hecht SS. Environmental tobacco smoke and lung cancer: The emerging role of carcinogen biomarkers and molecular epidemiology Journal of the National Cancer Institute. 86: 1369-1370. PMID 8072024 DOI: 10.1093/jnci/86.18.1369  0.96
1994 Peterson LA, Ng DK, Stearns RA, Hecht SS. Formation of NADP(H) analogs of tobacco-specific nitrosamines in rat liver and pancreatic microsomes. Chemical Research in Toxicology. 7: 599-608. PMID 7841337 DOI: 10.1021/tx00041a003  0.96
1993 Hecht SS, Trushin N, Reid-Quinn CA, Burak ES, Jones AB, Southers JL, Gombar CT, Carmella SG, Anderson LM, Rice JM. Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis. 14: 229-36. PMID 8435864 DOI: 10.1093/carcin/14.2.229  0.48
1993 Hecht SS, Carmella SG, Murphy SE, Akerkar S, Brunnemann KD, Hoffmann D. A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke. The New England Journal of Medicine. 329: 1543-6. PMID 8413477 DOI: 10.1056/NEJM199311183292105  0.96
1993 Hecht SS, Carmella SG, Murphy SE, Foiles PG, Chung FL. Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer Journal of Cellular Biochemistry. Supplement. 17: 27-35. PMID 8412204 DOI: 10.1002/jcb.240531005  0.96
1993 Swenson DH, el-Bayoumy K, Shuie GH, Hecht SS, Fiala E, Kadlubar FF, Freeman JP. Synthesis of N-(purin-8-yl)arylamines. Chemical Research in Toxicology. 6: 480-5. PMID 8374045 DOI: 10.1021/tx00034a014  0.96
1993 Alworth WL, Young-Sciame R, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450. Carcinogenesis. 14: 1711-3. PMID 8353857 DOI: 10.1093/carcin/14.8.1711  0.96
1993 Hecht SS, Carmella SG, Foiles PG, Murphy SE, Peterson LA. Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans. Environmental Health Perspectives. 99: 57-63. PMID 8319660 DOI: 10.1289/ehp.939957  0.96
1993 Ronai ZA, Gradia S, Peterson LA, Hecht SS. G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis. 14: 2419-22. PMID 7902220 DOI: 10.1093/carcin/14.11.2419  0.96
1992 Lasker SE, Iatropoulos MJ, Hecht SS, Misra B, Amin S, Zang E, Williams GM. N-ethyl-N-nitrosourea induced brain tumors in rats monitored by nuclear magnetic resonance imaging, plasma proton nuclear magnetic resonance spectroscopy and microscopy. Cancer Letters. 67: 125-31. PMID 1483261 DOI: 10.1016/0304-3835(92)90135-I  0.44
1992 Lin JM, Desai DH, Morse MA, Amin S, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol Chemical Research in Toxicology. 5: 674-679. PMID 1446008 DOI: 10.1021/tx00029a013  0.96
1991 Melikian AA, Goldin BF, Prahalad AK, Hecht SS. Modulation of benzo[a]pyrene-DNA adducts in hamster cheek pouch by chronic ethanol consumption. Chemical Research in Toxicology. 3: 139-43. PMID 2130941 DOI: 10.1021/tx00014a009  0.32
1991 Hoffmann D, Rivenson A, Chung FL, Hecht SS. Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. Critical Reviews in Toxicology. 21: 305-11. PMID 2069715 DOI: 10.3109/10408449109017917  0.88
1991 Rivenson A, Hecht SS, Hoffmann D. Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs. Critical Reviews in Toxicology. 21: 255-64. PMID 2069711 DOI: 10.3109/10408449109017913  0.88
1991 Hecht SS, Morse MA, Eklind KI, Chung FL. A/j mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates Experimental Lung Research. 17: 501-511. PMID 2050046 DOI: 10.3109/01902149109064435  0.96
1991 Amin S, Misra B, Braley J, Hecht SS. Comparative tumorigenicity in newborn mice of chrysene- and 5-alkylchrysene-1,2-diol-3,4-epoxides Cancer Letters. 58: 115-118. PMID 2049777 DOI: 10.1016/0304-3835(91)90032-D  0.96
1991 Peterson LA, Mathew R, B1P6Murphy SE, Trushin N, Hecht SS. In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 12: 2069-72. PMID 1934291 DOI: 10.1093/carcin/12.11.2069  0.96
1991 Hecht SS, Hoffmann D. N-nitroso compounds and tobacco-induced cancers in man. Iarc Scientific Publications. 54-61. PMID 1855913  0.88
1991 Anderson LM, Hecht SS, Kovatch RM, Amin S, Hoffmann D, Rice JM. Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice. Cancer Letters. 58: 177-81. PMID 1855194  0.88
1990 Peterson LA, Carmella SG, Hecht SS. Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 11: 1329-33. PMID 2387018 DOI: 10.1093/carcin/11.8.1329  0.96
1990 Murphy SE, Palomino A, Hecht SS, Hoffmann D. Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Research. 50: 5446-52. PMID 2386949  0.96
1990 Morse MA, Hecht SS, Chung FL. Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate Basic Life Sciences. 52: 345-350. PMID 2327941 DOI: 10.1007/978-1-4615-9561-8_30  0.96
1990 Morse MA, Reinhardt JC, Amin SG, Hecht SS, Stoner GD, Chung FL. Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice Cancer Letters. 49: 225-230. PMID 2317784 DOI: 10.1016/0304-3835(90)90163-R  0.96
1990 Spratt TE, Peterson LA, Confer WL, Hecht SS. Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles. Chemical Research in Toxicology. 3: 350-6. PMID 2133084 DOI: 10.1021/tx00016a013  0.96
1989 Hecht SS, Morse MA, Amin S, Stoner GD, Jordan KG, Choi CI, Chung FL. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosainino)-1-(3-pyridyl)-1-butanone and the effect of diet Carcinogenesis. 10: 1901-1904. PMID 2791206 DOI: 10.1093/carcin/10.10.1901  0.96
1989 Morse MA, Eklind KI, Amin SG, Hecht SS, Chung FL. Effects of alkyl chain length on the inhibition of nnk-induced lung neoplasia in a/j mice by arylalkyl isothiocyanates Carcinogenesis. 10: 1757-1759. PMID 2766468 DOI: 10.1093/carcin/10.9.1757  0.96
1989 Melikian AA, Hecht SS, Hoffmann D. Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues. Progress in Clinical and Biological Research. 298: 331-45. PMID 2748687  0.88
1989 Anderson LM, Hecht SS, Dixon DE, Dove LF, Kovatch RM, Amin S, Hoffmann D, Rice JM. Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. Cancer Research. 49: 3770-5. PMID 2736518  0.88
1989 Hecht SS, Hoffmann D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surveys. 8: 273-94. PMID 2696581  0.88
1989 Weyand EH, Amin S, Huie K, Boger E, Neuber E, Hecht SS, LaVoie EJ. Effects of fluorine substitution on the DNA binding and tumorigenicity of benzo[b]fluoranthene in mouse epidermis Chemico-Biological Interactions. 71: 279-290. PMID 2598303 DOI: 10.1016/0009-2797(89)90041-0  0.96
1989 Belinsky SA, White CM, Trushin N, Hecht SS. Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the fischer rat Carcinogenesis. 10: 2269-2274. PMID 2591016 DOI: 10.1093/carcin/10.12.2269  0.96
1989 Melikian AA, Jordan KG, Braley J, Rigotty J, Meschter CL, Hecht SS, Hoffmann D. Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes. Carcinogenesis. 10: 1897-900. PMID 2507190 DOI: 10.1093/carcin/10.10.1897  0.96
1989 Melikian AA, Bagheri K, Hecht SS, Hoffmann D. Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice. Chemico-Biological Interactions. 69: 245-57. PMID 2495193 DOI: 10.1016/0009-2797(89)90082-3  0.88
1988 Hecht SS, Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis. 9: 875-84. PMID 3286030  0.88
1988 Hecht SS, Carmella SG, Trushin N, Spratt TE, Foiles PG, Hoffmann D. Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. Iarc Scientific Publications. 121-8. PMID 3198194  0.88
1988 Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Research. 48: 6912-7. PMID 3180100  0.88
1988 Morse MA, Wang CX, Amin SG, Hecht SS, Chung FL. Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats Carcinogenesis. 9: 1891-1895. PMID 3168166 DOI: 10.1093/carcin/9.10.1891  0.96
1987 Hecht SS, Lin D, Castonguay A, Rivenson A. Effects of α-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in f344 rats Carcinogenesis. 8: 291-294. PMID 3802414 DOI: 10.1093/carcin/8.2.291  0.96
1987 Brunnemann KD, Rivenson A, Adams JD, Hecht SS, Hoffmann D. A study of snuff carcinogenesis. Iarc Scientific Publications. 456-9. PMID 3679421  0.88
1986 Palladino GF, Chung FL, Hecht SS. 3-(2-Deoxy-.beta.-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo[1,2-a]purin-9(3H)-one, a major deoxyguanosine adduct formed from a novel diazo hydroxide product of .alpha.-hydroxylation of the carcinogen N-nitrosomorpholine. Journal of the American Chemical Society. 108: 6066-8. PMID 22175388 DOI: 10.1021/ja00279a080  0.44
1986 el-Bayoumy K, Donahue JM, Hecht SS, Hoffmann D. Identification and quantitative determination of aniline and toluidines in human urine. Cancer Research. 46: 6064-7. PMID 3779628  0.88
1986 Hecht SS, Rivenson A, Braley J, DiBello J, Adams JD, Hoffmann D. Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. Cancer Research. 46: 4162-6. PMID 3731083  0.96
1986 Connolly GN, Winn DM, Hecht SS, Henningfield JE, Walker B, Hoffmann D. The reemergence of smokeless tobacco. The New England Journal of Medicine. 314: 1020-7. PMID 3515184 DOI: 10.1056/NEJM198604173141605  0.88
1986 Melikian AA, Leszczynska JM, Hecht SS, Hoffmann D. Effects of the co-carcinogen catechol on benzo[a]pyrene metabolism and DNA adduct formation in mouse skin. Carcinogenesis. 7: 9-15. PMID 3510752  0.88
1985 Castonguay A, Foiles PG, Trushin N, Hecht SS. Study of DNA methylation by tobacco-specific N-nitrosamines Environmental Health Perspectives. 197-202. PMID 4085424 DOI: 10.1289/ehp.8562197  0.96
1985 Murphy SE, Hecht SS. Dual-label high-performance liquid chromatographic assay for femtomole levels of benzo[a]pyrene metabolites Analytical Biochemistry. 146: 442-447. PMID 4025808 DOI: 10.1016/0003-2697(85)90567-6  0.96
1985 Melikian AA, Hecht SS, Hoffmann D, Pataki J, Harvey RG. Analysis of syn- and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene -deoxyribonucleoside adducts by boronate chromatography. Cancer Letters. 27: 91-7. PMID 4005825  0.88
1985 el-Bayoumy K, O'Donnell M, Hecht SS, Hoffmann D. On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke. Carcinogenesis. 6: 505-7. PMID 3986957  0.88
1985 Melikian AA, Leszczynska JM, Amin S, Hecht SS, Hoffmann D, Pataki J, Harvey RG. Rates of hydrolysis and extents of DNA binding of 5-methylchrysene dihydrodiol epoxides. Cancer Research. 45: 1990-6. PMID 3986755  0.88
1985 Hoffmann D, Lavoie EJ, Hecht SS. Nicotine: a precursor for carcinogens. Cancer Letters. 26: 67-75. PMID 3971354 DOI: 10.1016/0304-3835(85)90174-0  0.96
1985 Hoffmann D, Hecht SS. Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Research. 45: 935-44. PMID 3882226  0.88
1985 Hecht SS, Radok L, Amin S, Huie K, Melikian AA, Hoffmann D, Pataki J, Harvey RG. Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin. Cancer Research. 45: 1449-52. PMID 3838497  0.88
1984 Hoffmann D, Rivenson A, Amin S, Hecht SS. Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats. Journal of Cancer Research and Clinical Oncology. 108: 81-6. PMID 6746721 DOI: 10.1007/BF00390978  0.32
1984 Hecht SS, Morrison JB, Young R. N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine. Carcinogenesis. 5: 979-81. PMID 6733859 DOI: 10.1093/carcin/5.7.979  0.96
1984 Melikian AA, Amin S, Hecht SS, Hoffmann D, Pataki J, Harvey RG. Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro. Cancer Research. 44: 2524-9. PMID 6547075  0.88
1984 Hecht SS. N-nitroso-2-hydroxymorpholine, a mutagenic metabolite of n-nitrosodiethanolamine Carcinogenesis. 5: 1745-1747. PMID 6499128 DOI: 10.1093/carcin/5.12.1745  0.96
1983 Melikian AA, LaVoie EJ, Hecht SS, Hoffmann D. 5-Methylchrysene metabolism in mouse epidermis in vivo, diol epoxide--DNA adduct persistence, and diol epoxide reactivity with DNA as potential factors influencing the predominance of 5-methylchrysene-1,2-diol-3,4-epoxide--DNA adducts in mouse epidermis. Carcinogenesis. 4: 843-9. PMID 6872139 DOI: 10.1093/carcin/4.7.843  0.48
1983 Hoffmann D, Wynder EL, Rivenson A, LaVoie EJ, Hecht SS. Skin bioassays in tobacco carcinogenesis Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale Des Tumeurs. 26: 43-67. PMID 6844647 DOI: 10.1159/000407252  0.96
1983 Brunnemann KD, Hecht SS, Hoffmann D. N-nitrosamines: environmental occurrence, in vivo formation and metabolism. Journal of Toxicology. Clinical Toxicology. 19: 661-88. PMID 6761448 DOI: 10.3109/15563658208990397  0.4
1983 Morrison JB, Hecht SS, Wenninger JA. N-nitroso-N-methyloctadecylamine in hair-care products. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 21: 69-73. PMID 6681794 DOI: 10.1016/0278-6915(83)90270-3  0.96
1983 Hecht SS, Adams JD, Numoto S, Hoffmann D. Induction of respiratory tract tumors in syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation Carcinogenesis. 4: 1287-1290. PMID 6616756 DOI: 10.1093/carcin/4.10.1287  0.96
1983 Hoffmann D, Hecht SS, Wynder EL. Tumor promoters and cocarcinogens in tobacco carcinogenesis. Environmental Health Perspectives. 50: 247-57. PMID 6409604 DOI: 10.1289/ehp.8350247  0.44
1982 Hecht SS, Morrison JB, Wenninger JA. N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 20: 165-9. PMID 7200935 DOI: 10.1016/S0278-6915(82)80242-1  0.96
1982 Lavoie EJ, Hecht SS, Bedenko V, Hoffmann D. Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene Carcinogenesis. 3: 841-846. PMID 7127666 DOI: 10.1093/carcin/3.8.841  0.96
1982 Amin S, Lavoie EJ, Hecht SS. Identification of metabolites of benzo[b]fluoranthene Carcinogenesis. 3: 171-174. PMID 7067045 DOI: 10.1093/carcin/3.2.171  0.96
1982 Morrison JB, Hecht SS. N-Nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in household dishwashing liquids. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 20: 583-6. PMID 6890512 DOI: 10.1016/S0278-6915(82)80067-7  0.96
1981 Hecht SS, Chen CB, Hoffmann D. Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine. Journal of Medicinal Chemistry. 23: 1175-8. PMID 7452667 DOI: 10.1021/jm00185a005  0.44
1981 McCoy GD, Hecht SS, Wynder EL. The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers. Preventive Medicine. 9: 622-9. PMID 7433424 DOI: 10.1016/0091-7435(80)90034-1  0.4
1981 El-Bayoumy K, LaVoie EJ, Tulley-Freiler L, Hecht SS. Effects of ortho-methyl substituents on the mutagenicity of aminobiphenyls and aminonaphthalenes Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 90: 345-354. PMID 7038458 DOI: 10.1016/0165-1218(81)90057-4  0.96
1981 El-Bayoumy K, Lavoie EJ, Hecht SS, Fow EA, Hoffmann D. The influence of methyl substitution on the mutagenicity of nitronaphthalenes and nitrobiphenyls Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 81: 143-153. PMID 7017386 DOI: 10.1016/0027-5107(81)90029-4  0.96
1981 Hecht SS, Chen CB, Young R, Hoffmann D. Mass Spectra of Tobacco Alkaloid - Derived Nitrosamines, their Metabolites, and Related Compounds BeiträGe Zur Tabakforschung / Contributions to Tobacco Research. 11. DOI: 10.2478/cttr-2013-0498  0.32
1980 Hecht SS, Amin S, Rivenson A, Hoffmann D. Tumor initiating activity of 5,11-dimethylchrysene and the structural requirements favoring carcinogenicity of methylated polynuclear aromatic hydrocarbons. Cancer Letters. 8: 65-70. PMID 509421 DOI: 10.1016/0304-3835(79)90024-7  0.32
1979 Hecht SS, LaVole E, Mazzarese R, Hirota N, Ohmori T, Hoffmann D. Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes. Journal of the National Cancer Institute. 63: 855-61. PMID 288940 DOI: 10.1093/jnci/63.3.855  0.52
1978 Hecht SS, Chen CB, Hirota N, Ornaf RM, Tso TC, Hoffmann D. Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice. Journal of the National Cancer Institute. 60: 819-24. PMID 633391 DOI: 10.1093/jnci/60.4.819  0.52
1978 Hecht SS, Chen CB, Ornaf RM, Jacobs E, Adams JD, Hoffmann D. Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring. The Journal of Organic Chemistry. 43: 72-6. PMID 619049 DOI: 10.1021/jo00395a017  0.48
1978 Hecht SS, Loy M, Mazzarese R, Hoffmann D. Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene. Journal of Medicinal Chemistry. 21: 38-44. PMID 338903 DOI: 10.1021/jm00199a007  0.36
1978 Browne CE, Dobbs TK, Hecht SS, Eisenbraun EJ. Stereochemical assignment of (E)- and (Z)-2-(1-naphthyl)-1-phenylpropene and their photocyclization to 5-methylchrysene Journal of Organic Chemistry. 43: 1656-1660.  0.96
1977 Hilfrich J, Hecht SS, Hoffmann D. A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters. Cancer Letters. 2: 169-75. PMID 837363 DOI: 10.1016/S0304-3835(77)80007-4  0.68
1977 Hecht SS, Chen CB, Dong M, Ornaf RM, Hoffmann D, Tso TC. Chemical Studies on Tobacco Smoke: LI: Studies on Non-Volatile Nitrosamines in Tobacco BeiträGe Zur Tabakforschung / Contributions to Tobacco Research. 9: 1-6. DOI: 10.2478/cttr-2013-0419  0.32
1976 Hoffmann D, Raineri R, Hecht SS, Maronpot R, Wynder EL. A study of tobacco carcinogenesis. XIV. Effects of N'-nitrosonornicotine and N'-nitrosonanabasine in rats. Journal of the National Cancer Institute. 55: 977-81. PMID 1237631 DOI: 10.1093/jnci/55.4.977  0.6
1976 Hecht SS, Ornaf RM, Hoffmann D. Determination of N'-nitrosonornicotine in tobacco by high speed liquid chromatography. Analytical Chemistry. 47: 2046-8. PMID 1190465 DOI: 10.1021/ac60362a037  0.68
1975 Hecht SS, Bondinell WE, Hoffmann D. Chrysene and methylchrysenes: presence in tobacco smoke and carcinogenicity. Journal of the National Cancer Institute. 53: 1121-33. PMID 4427391 DOI: 10.1093/jnci/53.4.1121  0.52
1975 Hecht SS, Ornaf RM, Hoffmann D. Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications. Journal of the National Cancer Institute. 54: 1237-44. PMID 236398 DOI: 10.1093/jnci/54.5.1237  0.64
1975 Hecht SS, Thorne RL, Maronpot RR, Hoffmann D. A study of tobacco carcinogenesis. XIII. Tumor-promoting subfractions of the weakly acidic fraction. Journal of the National Cancer Institute. 55: 1329-36. PMID 1547 DOI: 10.1093/jnci/55.6.1329  0.88
1974 Hoffmann D, Hecht SS, Ornaf RM, Wynder EL. N'-nitrosonornicotine in tobacco. Science (New York, N.Y.). 186: 265-7. PMID 4414773 DOI: 10.1126/science.186.4160.265  0.6
1972 Hecht SS. Reaction of hydrazine with 1,2-diphenyi-3-dibenzoylmethylenecyclopropene and 1,2-diphenyl-3-diacetylmethylenecyclopropene; formation of pyridazines Tetrahedron Letters. 13: 3731-3734. DOI: 10.1016/S0040-4039(01)94148-6  0.96
1970 Hecht SS. Alkylation of metal derivatives of 1,3-diphenyl-1,3-propanedione with 1,2-diphenyl-3,3-dichlorocyclopropene Tetrahedron Letters. 11: 4385-4388. DOI: 10.1016/S0040-4039(00)89438-1  0.96
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