Chengguo Xing - Publications

Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Pharmaceutical Chemistry, Organic Chemistry

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhou B, Jiang P, Lu J, Xing C. Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones. Archiv Der Pharmazie. PMID 27214789 DOI: 10.1002/ardp.201500434  0.96
2016 Puppala M, Zhao X, Casemore D, Zhou B, Aridoss G, Narayanapillai S, Xing C. 4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions. Bioorganic & Medicinal Chemistry. PMID 26867486 DOI: 10.1016/j.bmc.2016.01.056  0.96
2016 Narayanapillai S, von Weymarn L, Carmella S, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy S, Xing C. Dietary Dihydromethysticin (DHM) Increases Glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-Butanol (NNAL) in A/J Mice, Potentially Enhancing its Detoxification. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26744252 DOI: 10.1124/dmd.115.068387  0.96
2015 Savage KM, Stough CK, Byrne GJ, Scholey A, Bousman C, Murphy J, Macdonald P, Suo C, Hughes M, Thomas S, Teschke R, Xing C, Sarris J. Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial. Trials. 16: 493. PMID 26527536 DOI: 10.1186/s13063-015-0986-5  0.96
2015 Zhang J, Li L, Hale TW, Chee W, Xing C, Jiang C, Lü J. Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women. Plos One. 10: e0114992. PMID 25695490 DOI: 10.1371/journal.pone.0114992  0.96
2015 Shi S, Wang Q, Xu J, Jang JH, Padilla MT, Nyunoya T, Xing C, Zhang L, Lin Y. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget. 6: 1640-51. PMID 25682199  0.96
2014 Martin AC, Johnston E, Xing C, Hegeman AD. Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster). Plos One. 9: e111572. PMID 25365244 DOI: 10.1371/journal.pone.0111572  0.96
2014 Narayanapillai SC, Leitzman P, O'Sullivan MG, Xing C. Flavokawains A and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice Chemical Research in Toxicology. 27: 1871-1876. PMID 25185080 DOI: 10.1021/tx5003194  0.96
2014 Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C. Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 35: 2365-72. PMID 25053626 DOI: 10.1093/carcin/bgu149  0.96
2014 Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. The Journal of Biological Chemistry. 289: 11873-96. PMID 24616095 DOI: 10.1074/jbc.M114.552562  0.96
2014 Zhuang C, Narayanapillai S, Zhang W, Sham YY, Xing C. Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search. Journal of Medicinal Chemistry. 57: 1121-6. PMID 24417449 DOI: 10.1021/jm4017174  0.96
2014 Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O'Sullivan MG, Hecht SS, Lu J, Xing C. Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 7: 86-96. PMID 24403291 DOI: 10.1158/1940-6207.CAPR-13-0301  0.96
2013 Bleeker NP, Cornea RL, Thomas DD, Xing C. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Molecular Pharmaceutics. 10: 4358-66. PMID 24079514 DOI: 10.1021/mp400458u  0.96
2013 Hermanson DL, Das SG, Li Y, Xing C. Overexpression of Mcl-1 confers multidrug resistance, whereas topoisomerase IIβ downregulation introduces mitoxantrone-specific drug resistance in acute myeloid leukemia. Molecular Pharmacology. 84: 236-43. PMID 23696245 DOI: 10.1124/mol.113.086140  0.36
2013 Das SG, Hermanson DL, Bleeker N, Lowman X, Li Y, Kelekar A, Xing C. Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy. Acs Chemical Biology. 8: 327-35. PMID 23102022 DOI: 10.1021/cb300460f  0.36
2012 Zhang Y, Srinivasan B, Xing C, Lü J. A new chalcone derivative (E)-3-(4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one suppresses prostate cancer involving p53-mediated cell cycle arrests and apoptosis. Anticancer Research. 32: 3689-98. PMID 22993307  0.36
2012 Warmka JK, Solberg EL, Zeliadt NA, Srinivasan B, Charlson AT, Xing C, Wattenberg EV. Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog. Biochemical and Biophysical Research Communications. 424: 488-92. PMID 22771807 DOI: 10.1016/j.bbrc.2012.06.140  0.36
2012 Aridoss G, Zhou B, Hermanson DL, Bleeker NP, Xing C. Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment. Journal of Medicinal Chemistry. 55: 5566-81. PMID 22582991 DOI: 10.1021/jm300515q  0.36
2011 Das SG, Srinivasan B, Hermanson DL, Bleeker NP, Doshi JM, Tang R, Beck WT, Xing C. Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues. Journal of Medicinal Chemistry. 54: 5937-48. PMID 21780800 DOI: 10.1021/jm200764t  0.96
2011 Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C. Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. The American Journal of Chinese Medicine. 39: 727-42. PMID 21721153 DOI: 10.1142/S0192415X11009202  0.96
2011 Srinivasan B, Li Y, Jing Y, Xing C, Slaton J, Wang JP. A three-layer competition-based giant magnetoresistive assay for direct quantification of endoglin from human urine. Analytical Chemistry. 83: 2996-3002. PMID 21417448 DOI: 10.1021/ac2005229  0.36
2011 Srinivasan B, Johnson TE, Xing C. Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. Bioorganic & Medicinal Chemistry Letters. 21: 555-7. PMID 21112783 DOI: 10.1016/j.bmcl.2010.10.063  0.96
2010 Li Y, Srinivasan B, Jing Y, Yao X, Hugger MA, Wang JP, Xing C. Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera. Journal of the American Chemical Society. 132: 4388-92. PMID 20192199 DOI: 10.1021/ja910406a  0.36
2010 Zhang Q, Srinivasan B, Li Y, Jing Y, Xing C, Chang J, Wang JP. A new and facile method for measurement of apparent density of monodisperse polymer beads. Talanta. 80: 1681-5. PMID 20152396 DOI: 10.1016/j.talanta.2009.10.004  0.36
2009 Li Y, Jing Y, Yao X, Srinivasan B, Xu Y, Xing C, Wang JP. Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5432-5. PMID 19963642 DOI: 10.1109/IEMBS.2009.5332479  0.36
2009 Srinivasan B, Johnson TE, Lad R, Xing C. Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. Journal of Medicinal Chemistry. 52: 7228-35. PMID 19883086 DOI: 10.1021/jm901278z  0.96
2009 Das SG, Doshi JM, Tian D, Addo SN, Srinivasan B, Hermanson DL, Xing C. Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. Journal of Medicinal Chemistry. 52: 5937-49. PMID 19743858 DOI: 10.1021/jm9005059  0.96
2009 Shaik AA, Hermanson DL, Xing C. Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. Bioorganic & Medicinal Chemistry Letters. 19: 5732-6. PMID 19716299 DOI: 10.1016/j.bmcl.2009.08.003  0.36
2009 Hermanson D, Addo SN, Bajer AA, Marchant JS, Das SG, Srinivasan B, Al-Mousa F, Michelangeli F, Thomas DD, Lebien TW, Xing C. Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria. Molecular Pharmacology. 76: 667-78. PMID 19561125 DOI: 10.1124/mol.109.055830  0.96
2009 Srinivasan B, Li Y, Jing Y, Xu Y, Yao X, Xing C, Wang JP. A detection system based on giant magnetoresistive sensors and high-moment magnetic nanoparticles demonstrates zeptomole sensitivity: potential for personalized medicine. Angewandte Chemie (International Ed. in English). 48: 2764-7. PMID 19288507 DOI: 10.1002/anie.200806266  0.36
2008 Xing C, Johnson TE, Limburg PJ. Diets, phytochemicals, and chemoprevention of tumorigenesis. Journal of Dietary Supplements. 5: 95-105. PMID 22432428 DOI: 10.1080/19390210802332877  0.96
2008 Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, Upadhyaya P, Ruvolo PP, Hecht SS, Xing C. Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 1: 430-8. PMID 19138990 DOI: 10.1158/1940-6207.CAPR-08-0027  0.96
2008 Gupte A, Boshoff HI, Wilson DJ, Neres J, Labello NP, Somu RV, Xing C, Barry CE, Aldrich CC. Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 51: 7495-507. PMID 19053762 DOI: 10.1021/jm8008037  0.96
2008 Wang L, Sloper DT, Addo SN, Tian D, Slaton JW, Xing C. WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth. Cancer Research. 68: 4377-83. PMID 18519699 DOI: 10.1158/0008-5472.CAN-07-6590  0.4
2008 Tian D, Das SG, Doshi JM, Peng J, Lin J, Xing C. sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. Cancer Letters. 259: 198-208. PMID 18037229 DOI: 10.1016/j.canlet.2007.10.012  0.96
2008 Wang L, Kong F, Kokoski CL, Andrews DW, Xing C. Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorganic & Medicinal Chemistry Letters. 18: 236-40. PMID 18023349 DOI: 10.1016/j.bmcl.2007.10.088  0.96
2008 Doshi JM, Xing C. Antagonists against anti-apoptotic Bcl-2 family proteins for cancer treatment Mini-Reviews in Organic Chemistry. 5: 171-178. DOI: 10.2174/157019308785161639  0.96
2007 Doshi JM, Tian D, Xing C. Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. Molecular Pharmaceutics. 4: 919-28. PMID 17874842 DOI: 10.1021/mp7000846  0.96
2007 Xing C, Wang L, Tang X, Sham YY. Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. Bioorganic & Medicinal Chemistry. 15: 2167-76. PMID 17227711 DOI: 10.1016/j.bmc.2006.12.020  0.96
2006 Doshi JM, Tian D, Xing C. Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. Journal of Medicinal Chemistry. 49: 7731-9. PMID 17181155 DOI: 10.1021/jm060968r  0.96
2004 Xing C, LaPorte JR, Barbay JK, Myers AG. Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proceedings of the National Academy of Sciences of the United States of America. 101: 5862-6. PMID 15079082 DOI: 10.1073/pnas.0307476101  0.96
2000 Xing C, Skibo EB. Sigmatropic reactions of the aziridinyl semiquinone species. Why aziridinyl benzoquinones are metabolically more stable than aziridinyl indoloquinones Biochemistry. 39: 10770-10780. PMID 10978162 DOI: 10.1021/bi000885r  0.96
1998 Skibo EB, Xing C. Chemistry and DNA alkylation reactions of aziridinyl quinones: Development of an efficient alkylating agent of the phosphate backbone Biochemistry. 37: 15199-15213. PMID 9790684 DOI: 10.1021/bi981204j  0.96
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