David Dale Thomas - Publications

1979- Biochemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Structural Biology

236 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Sandford SM, Taylor SS, Veglia G. Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Communications Biology. 4: 321. PMID 33692454 DOI: 10.1038/s42003-021-01819-6  0.4
2021 Li A, Yuen SL, Stroik DR, Kleinboehl E, Cornea RL, Thomas DD. The transmembrane peptide DWORF activates SERCA2a via dual mechanisms. The Journal of Biological Chemistry. 100412. PMID 33581112 DOI: 10.1016/j.jbc.2021.100412  1
2021 Majumdar A, Burban DJ, Muretta JM, Thompson AR, Engel TA, Rasmussen DM, Subrahmanian MV, Veglia G, Thomas DD, Levinson NM. Allostery governs Cdk2 activation and differential recognition of CDK inhibitors. Nature Chemical Biology. PMID 33526892 DOI: 10.1038/s41589-020-00725-y  0.52
2021 Lo CH, Schaaf TM, Thomas DD, Sachs JN. Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators. Methods in Molecular Biology (Clifton, N.J.). 2248: 121-137. PMID 33185872 DOI: 10.1007/978-1-0716-1130-2_9  1
2020 Nelson SED, Weber DK, Rebbeck RT, Cornea RL, Veglia G, Thomas DD. Met125 is essential for maintaining the structural integrity of calmodulin's C-terminal domain. Scientific Reports. 10: 21320. PMID 33288831 DOI: 10.1038/s41598-020-78270-w  1
2020 Autry JM, Karim CB, Perumbakkam S, Finno CJ, McKenzie EC, Thomas DD, Valberg SJ. Sarcolipin Exhibits Abundant RNA Transcription and Minimal Protein Expression in Horse Gluteal Muscle. Veterinary Sciences. 7. PMID 33202832 DOI: 10.3390/vetsci7040178  1
2020 Nikolaienko R, Bovo E, Rebbeck RT, Kahn D, Thomas DD, Cornea RL, Zima AV. The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor. Redox Biology. 37: 101729. PMID 32980662 DOI: 10.1016/j.redox.2020.101729  1
2020 Autry JM, Karim CB, Cocco M, Carlson SF, Thomas DD, Valberg SJ. Purification of sarcoplasmic reticulum vesicles from horse gluteal muscle. Analytical Biochemistry. 113965. PMID 32956693 DOI: 10.1016/j.ab.2020.113965  1
2020 Guhathakurta P, Phung LA, Prochniewicz E, Lichtenberger S, Wilson A, Thomas DD. Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle. The Journal of Biological Chemistry. PMID 32788211 DOI: 10.1074/jbc.RA120.014445  0.52
2020 Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas D, Langen R, Sachs JN. Discovery of small molecule inhibitors of huntingtin exon 1 aggregation by FRET-based high-throughput screening in living cells. Acs Chemical Neuroscience. PMID 32568514 DOI: 10.1021/acschemneuro.0c00226  0.32
2020 Schaaf TM, Kleinboehl E, Yuen SL, Roelike LN, Svensson B, Thompson AR, Cornea RL, Thomas DD. Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca Transport. Cells. 9. PMID 32397211 DOI: 10.3390/cells9051170  1
2020 McCarthy MR, Savich Y, Cornea RL, Thomas DD. Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release. Biophysical Journal. PMID 32049056 DOI: 10.1016/j.bpj.2020.01.010  1
2020 Rebbeck RT, Singh DP, Janicek KA, Bers DM, Thomas DD, Launikonis BS, Cornea RL. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca assays. Scientific Reports. 10: 1791. PMID 32019969 DOI: 10.1038/s41598-020-58461-1  1
2020 Lindsay A, Baumann CW, Rebbeck RT, Yuen SL, Southern WM, Hodges JS, Cornea RL, Thomas DD, Ervasti JM, Lowe DA. Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators. Skeletal Muscle. 10: 3. PMID 32007101 DOI: 10.1186/s13395-020-0221-2  1
2019 Stroik DR, Ceholski DK, Bidwell PA, Mleczko J, Thanel PF, Kamdar F, Autry JM, Cornea RL, Thomas DD. Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs. Journal of Molecular and Cellular Cardiology. PMID 31751570 DOI: 10.1016/j.yjmcc.2019.11.147  1
2019 Martin PD, Svensson B, Thomas DD, Stoll S. Trajectory-Based Simulation of EPR Spectra: Models of Rotational Motion for Spin Labels on Proteins. The Journal of Physical Chemistry. B. PMID 31693365 DOI: 10.1021/acs.jpcb.9b02693  1
2019 Lo CH, Lim CK, Ding Z, Wickramasinghe SP, Braun AR, Ashe KH, Rhoades E, Thomas DD, Sachs JN. Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31653529 DOI: 10.1016/j.jalz.2019.06.4954  0.32
2019 Lo CH, Schaaf TM, Grant BD, Lim CK, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN. Noncompetitive inhibitors of TNFR1 probe conformational activation states. Science Signaling. 12. PMID 31363069 DOI: 10.1126/scisignal.aav5637  1
2019 Binder BP, Thompson AR, Thomas DD. Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label. Biophysical Journal. PMID 31301803 DOI: 10.1016/j.bpj.2019.04.042  0.56
2019 Savich Y, Binder BP, Thompson AR, Thomas DD. Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels. The Journal of General Physiology. PMID 31227551 DOI: 10.1085/jgp.201812210  0.56
2019 Valberg SJ, Soave K, Williams ZJ, Perumbakkam S, Schott M, Finno CJ, Petersen JL, Fenger C, Autry JM, Thomas DD. Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis. Journal of Veterinary Internal Medicine. PMID 30720217 DOI: 10.1111/jvim.15425  1
2018 Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM. Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states. Proceedings of the National Academy of Sciences of the United States of America. PMID 30518564 DOI: 10.1073/pnas.1811158115  0.52
2018 Schaaf TM, Li A, Grant BD, Peterson K, Yuen S, Bawaskar P, Kleinboehl E, Li J, Thomas DD, Gillispie GD. Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening. Biosensors. 8. PMID 30352972 DOI: 10.3390/bios8040099  1
2018 Phung LA, Karvinen SM, Colson BA, Thomas DD, Lowe DA. Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice. Plos One. 13: e0199062. PMID 30226869 DOI: 10.1371/journal.pone.0199062  0.44
2018 Guhathakurta P, Prochniewicz E, Thomas DD. Actin-Myosin Interaction: Structure, Function and Drug Discovery. International Journal of Molecular Sciences. 19. PMID 30189615 DOI: 10.3390/ijms19092628  0.52
2018 Stroik DR, Yuen SL, Janicek KA, Schaaf TM, Li J, Ceholski DK, Hajjar RJ, Cornea RL, Thomas DD. Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells. Scientific Reports. 8: 12560. PMID 30135432 DOI: 10.1038/s41598-018-29685-z  1
2018 Her C, Thompson AR, Karim CB, Thomas DD. Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels. Scientific Reports. 8: 10681. PMID 30013092 DOI: 10.1038/s41598-018-29064-8  0.84
2018 Fealey ME, Horn B, Coffman C, Miller R, Lin AY, Thompson AR, Schramel J, Groth E, Hinderliter A, Cembran A, Thomas DD. Dynamics of Dystrophin's Actin-Binding Domain. Biophysical Journal. PMID 30007583 DOI: 10.1016/j.bpj.2018.05.039  0.52
2018 Martin PD, James ZM, Thomas DD. Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophysical Journal. 114: 2573-2583. PMID 29874608 DOI: 10.1016/j.bpj.2018.04.035  0.84
2018 Guhathakurta P, Prochniewicz E, Grant BD, Peterson KC, Thomas DD. High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin-myosin structure and function. The Journal of Biological Chemistry. PMID 29866882 DOI: 10.1074/jbc.RA118.002702  1
2018 Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, et al. Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology. PMID 29752948 DOI: 10.1016/j.yjmcc.2018.05.007  1
2018 Nelson SED, Ha KN, Gopinath T, Exline MH, Mascioni A, Thomas DD, Veglia G. Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers. Biochimica Et Biophysica Acta. PMID 29501609 DOI: 10.1016/j.bbamem.2018.02.030  0.4
2018 Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. Elife. 7. PMID 29465396 DOI: 10.7554/eLife.32766  0.52
2018 Fealey ME, Binder BP, Uversky VN, Hinderliter A, Thomas DD. Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR. Biophysical Journal. 114: 550-561. PMID 29414700 DOI: 10.1016/j.bpj.2017.12.013  0.56
2017 Avery AW, Fealey ME, Wang F, Orlova A, Thompson AR, Thomas DD, Hays TS, Egelman EH. Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation. Nature Communications. 8: 1350. PMID 29116080 DOI: 10.1038/s41467-017-01367-w  0.52
2017 Elam WA, Cao W, Kang H, Huehn A, Hocky GM, Prochniewicz E, Schramm AC, Negrón K, Garcia J, Bonello TT, Gunning PW, Thomas DD, Voth GA, Sindelar CV, De La Cruz EM. Phosphomimetic S3D-Cofilin Binds But Only Weakly Severs Actin Filaments. The Journal of Biological Chemistry. PMID 28939776 DOI: 10.1074/jbc.M117.808378  0.52
2017 Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN. Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-induced Apoptosis by Disrupting Receptor-Receptor Interactions. Journal of Molecular Biology. PMID 28834692 DOI: 10.1016/j.jmb.2017.08.009  0.32
2017 Guhathakurta P, Prochniewicz E, Roopnarine O, Rohde JA, Thomas DD. A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure. Biophysical Journal. 113: 91-100. PMID 28700929 DOI: 10.1016/j.bpj.2017.05.027  0.52
2017 Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors. Slas Discovery. 2472555217706478. PMID 28530838 DOI: 10.1177/2472555217706478  1
2016 Her C, McCaffrey JE, Thomas DD, Karim CB. Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin. Biophysical Journal. 111: 2387-2394. PMID 27926840 DOI: 10.1016/j.bpj.2016.10.025  0.84
2016 Schaaf TM, Peterson KC, Grant BD, Bawaskar P, Yuen S, Li J, Muretta JM, Gillispie GD, Thomas DD. High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA. Journal of Biomolecular Screening. PMID 27899691 DOI: 10.1177/1087057116680151  1
2016 Schaaf TM, Peterson KC, Grant BD, Thomas DD, Gillispie GD. Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells. Journal of Biomolecular Screening. PMID 27879398 DOI: 10.1177/1087057116679637  1
2016 Bian T, Autry JM, Casemore D, Li J, Thomas DD, He G, Xing C. Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles. Biochemical and Biophysical Research Communications. PMID 27815070 DOI: 10.1016/j.bbrc.2016.10.096  1
2016 Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL. High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels. Journal of Biomolecular Screening. PMID 27760856 DOI: 10.1177/1087057116674312  1
2016 Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW. A novel FRET-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters. Antimicrobial Agents and Chemotherapy. PMID 27736766 DOI: 10.1128/AAC.00218-16  1
2016 Autry JM, Thomas DD, Espinoza-Fonseca LM. Sarcolipin promotes uncoupling of the SERCA Ca(2+) pump by inducing a structural rearrangement in the energy-transduction domain. Biochemistry. PMID 27731980 DOI: 10.1021/acs.biochem.6b00728  1
2016 Swanson CJ, Sommese RF, Petersen KJ, Ritt M, Karslake J, Thomas DD, Sivaramakrishnan S. Calcium Stimulates Self-Assembly of Protein Kinase C α In Vitro. Plos One. 11: e0162331. PMID 27706148 DOI: 10.1371/journal.pone.0162331  1
2016 Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, et al. Oxidation increases the strength of the methionine-aromatic interaction. Nature Chemical Biology. PMID 27547920 DOI: 10.1038/nchembio.2159  1
2016 Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL. S100A1 does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor/calmodulin complex. The Journal of Biological Chemistry. PMID 27226555 DOI: 10.1074/jbc.M115.713107  1
2016 Colson BA, Thompson AR, Espinoza-Fonseca LM, Thomas DD. Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26908877 DOI: 10.1073/pnas.1521281113  0.52
2016 Avery AW, Crain J, Thomas DD, Hays TS. A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding. Scientific Reports. 6: 21375. PMID 26883385 DOI: 10.1038/srep21375  1
2016 Svensson B, Autry JM, Thomas DD. Molecular Modeling of Fluorescent SERCA Biosensors. Methods in Molecular Biology (Clifton, N.J.). 1377: 503-22. PMID 26695057 DOI: 10.1007/978-1-4939-3179-8_42  1
2015 McCaffrey JE, James ZM, Svensson B, Binder BP, Thomas DD. A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 262: 50-56. PMID 26720587 DOI: 10.1016/j.jmr.2015.12.005  1
2015 Muretta JM, Rohde JA, Johnsrud DO, Cornea S, Thomas DD. Direct real-time detection of the structural and biochemical events in the myosin power stroke. Proceedings of the National Academy of Sciences of the United States of America. 112: 14272-7. PMID 26578772 DOI: 10.1073/pnas.1514859112  1
2015 Karim CB, Michel Espinoza-Fonseca L, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. Erratum: Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. Scientific Reports. 5: 15872. PMID 26513659 DOI: 10.1038/srep15872  0.84
2015 Thompson AR, Binder BP, McCaffrey JE, Svensson B, Thomas DD. Bifunctional Spin Labeling of Muscle Proteins: Accurate Rotational Dynamics, Orientation, and Distance by EPR. Methods in Enzymology. 564: 101-23. PMID 26477249 DOI: 10.1016/bs.mie.2015.06.029  1
2015 Karim CB, Michel Espinoza-Fonseca L, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. Scientific Reports. 5: 14557. PMID 26411306 DOI: 10.1038/srep14557  1
2015 Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. Journal of Molecular and Cellular Cardiology. PMID 26092277 DOI: 10.1016/j.yjmcc.2015.06.009  1
2015 Binder BP, Cornea S, Thompson AR, Moen RJ, Thomas DD. High-resolution helix orientation in actin-bound myosin determined with a bifunctional spin label. Proceedings of the National Academy of Sciences of the United States of America. 112: 7972-7. PMID 26056276 DOI: 10.1073/pnas.1500625112  1
2015 Alamo L, Li XE, Espinoza-Fonseca LM, Pinto A, Thomas DD, Lehman W, Padrón R. Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back. Molecular Biosystems. 11: 2180-9. PMID 26038302 DOI: 10.1039/c5mb00163c  1
2015 Espinoza-Fonseca LM, Alamo L, Pinto A, Thomas DD, Padrón R. Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition. Molecular Biosystems. 11: 2167-79. PMID 26038232 DOI: 10.1039/c5mb00162e  1
2015 Espinoza-Fonseca LM, Autry JM, Thomas DD. Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state. Biochemical and Biophysical Research Communications. 463: 37-41. PMID 25983321 DOI: 10.1016/j.bbrc.2015.05.012  1
2015 Iram SH, Gruber SJ, Raguimova ON, Thomas DD, Robia SL. ATP-Binding Cassette Transporter Structure Changes Detected by Intramolecular Fluorescence Energy Transfer for High-Throughput Screening. Molecular Pharmacology. 88: 84-94. PMID 25924616 DOI: 10.1124/mol.114.096792  1
2015 Espinoza-Fonseca LM, Autry JM, Ramírez-Salinas GL, Thomas DD. Atomic-level mechanisms for phospholamban regulation of the calcium pump. Biophysical Journal. 108: 1697-708. PMID 25863061 DOI: 10.1016/j.bpj.2015.03.004  1
2015 Guhathakurta P, Prochniewicz E, Thomas DD. Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain. Proceedings of the National Academy of Sciences of the United States of America. 112: 4660-5. PMID 25825773 DOI: 10.1073/pnas.1420101112  1
2015 Ablorh NA, Thomas DD. Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy. Biophysical Reviews. 7: 63-76. PMID 25774229 DOI: 10.1007/s12551-014-0157-z  1
2015 McCaffrey JE, James ZM, Thomas DD. Optimization of bicelle lipid composition and temperature for EPR spectroscopy of aligned membranes. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 250: 71-5. PMID 25514061 DOI: 10.1016/j.jmr.2014.09.026  1
2015 McCarthy MR, Thompson AR, Nitu F, Moen RJ, Olenek MJ, Klein JC, Thomas DD. Impact of methionine oxidation on calmodulin structural dynamics. Biochemical and Biophysical Research Communications. 456: 567-72. PMID 25478640 DOI: 10.1016/j.bbrc.2014.11.091  1
2015 Colson BA, Petersen KJ, Collins BC, Lowe DA, Thomas DD. The myosin super-relaxed state is disrupted by estradiol deficiency. Biochemical and Biophysical Research Communications. 456: 151-5. PMID 25446114 DOI: 10.1016/j.bbrc.2014.11.050  1
2014 Petersen KJ, Peterson KC, Muretta JM, Higgins SE, Gillispie GD, Thomas DD. Fluorescence lifetime plate reader: resolution and precision meet high-throughput. The Review of Scientific Instruments. 85: 113101. PMID 25430092 DOI: 10.1063/1.4900727  1
2014 Svensson B, Oda T, Nitu FR, Yang Y, Cornea I, Chen-Izu Y, Fessenden JD, Bers DM, Thomas DD, Cornea RL. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophysical Journal. 107: 2037-48. PMID 25418089 DOI: 10.1016/j.bpj.2014.09.029  1
2014 Moen RJ, Cornea S, Oseid DE, Binder BP, Klein JC, Thomas DD. Redox-sensitive residue in the actin-binding interface of myosin. Biochemical and Biophysical Research Communications. 453: 345-9. PMID 25264102 DOI: 10.1016/j.bbrc.2014.09.072  1
2014 Ablorh NA, Dong X, James ZM, Xiong Q, Zhang J, Thomas DD, Karim CB. Synthetic phosphopeptides enable quantitation of the content and function of the four phosphorylation states of phospholamban in cardiac muscle. The Journal of Biological Chemistry. 289: 29397-405. PMID 25190804 DOI: 10.1074/jbc.M114.556621  0.96
2014 Mahalingam M, Girgenrath T, Svensson B, Thomas DD, Cornea RL, Fessenden JD. Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer. Structure (London, England : 1993). 22: 1322-32. PMID 25132084 DOI: 10.1016/j.str.2014.07.003  1
2014 Espinoza-Fonseca LM, Colson BA, Thomas DD. Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain. Molecular Biosystems. 10: 2693-8. PMID 25091814 DOI: 10.1039/c4mb00364k  1
2014 Dong X, Thomas DD. Time-resolved FRET reveals the structural mechanism of SERCA-PLB regulation. Biochemical and Biophysical Research Communications. 449: 196-201. PMID 24813991 DOI: 10.1016/j.bbrc.2014.04.166  1
2014 Espinoza-Fonseca LM, Autry JM, Thomas DD. Microsecond molecular dynamics simulations of Mg²⁺- and K⁺-bound E1 intermediate states of the calcium pump. Plos One. 9: e95979. PMID 24760008 DOI: 10.1371/journal.pone.0095979  1
2014 Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN. Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation. Biophysical Journal. 106: L21-4. PMID 24655519 DOI: 10.1016/j.bpj.2014.01.044  1
2014 Gruber SJ, Cornea RL, Li J, Peterson KC, Schaaf TM, Gillispie GD, Dahl R, Zsebo KM, Robia SL, Thomas DD. Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells. Journal of Biomolecular Screening. 19: 215-22. PMID 24436077 DOI: 10.1177/1087057113510740  1
2014 Moen RJ, Klein JC, Thomas DD. Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins. Exercise and Sport Sciences Reviews. 42: 30-6. PMID 24188980 DOI: 10.1249/JES.0000000000000004  1
2013 Greaser ML, Potter JD, Thomas DD, Strasburg GM, Lehrer SS, Wang CL, Grabarek Z. John Gergely (1919-2013): a pillar in the muscle protein field. Journal of Muscle Research and Cell Motility. 34: 441-6. PMID 24264290 DOI: 10.1007/s10974-013-9370-9  1
2013 Muretta JM, Behnke-Parks WM, Major J, Petersen KJ, Goulet A, Moores CA, Thomas DD, Rosenfeld SS. Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study. The Journal of Biological Chemistry. 288: 34839-49. PMID 24145034 DOI: 10.1074/jbc.M113.518845  1
2013 Pallikkuth S, Blackwell DJ, Hu Z, Hou Z, Zieman DT, Svensson B, Thomas DD, Robia SL. Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase. Biophysical Journal. 105: 1812-21. PMID 24138857 DOI: 10.1016/j.bpj.2013.08.045  1
2013 Bleeker NP, Cornea RL, Thomas DD, Xing C. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Molecular Pharmaceutics. 10: 4358-66. PMID 24079514 DOI: 10.1021/mp400458u  1
2013 Muretta JM, Thomas DD. Mutation that causes hypertrophic cardiomyopathy increases force production in human β-cardiac myosin. Proceedings of the National Academy of Sciences of the United States of America. 110: 12507-8. PMID 23852727 DOI: 10.1073/pnas.1310669110  1
2013 Trivedi DV, Muretta JM, Swenson AM, Thomas DD, Yengo CM. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry. 52: 4710-22. PMID 23725637 DOI: 10.1021/bi4004364  1
2013 Muretta JM, Petersen KJ, Thomas DD. Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain. Proceedings of the National Academy of Sciences of the United States of America. 110: 7211-6. PMID 23589853 DOI: 10.1073/pnas.1222257110  1
2013 Prochniewicz E, Guhathakurta P, Thomas DD. The structural dynamics of actin during active interaction with myosin depends on the isoform of the essential light chain. Biochemistry. 52: 1622-30. PMID 23339370 DOI: 10.1021/bi3014467  1
2013 Moen RJ, Thomas DD, Klein JC. Conformationally trapping the actin-binding cleft of myosin with a bifunctional spin label. The Journal of Biological Chemistry. 288: 3016-24. PMID 23250750 DOI: 10.1074/jbc.M112.428565  1
2013 Cornea RL, Gruber SJ, Lockamy EL, Muretta JM, Jin D, Chen J, Dahl R, Bartfai T, Zsebo KM, Gillispie GD, Thomas DD. High-throughput FRET assay yields allosteric SERCA activators. Journal of Biomolecular Screening. 18: 97-107. PMID 22923787 DOI: 10.1177/1087057112456878  1
2012 Colson BA, Rybakova IN, Prochniewicz E, Moss RL, Thomas DD. Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 109: 20437-42. PMID 23169656 DOI: 10.1073/pnas.1213027109  0.52
2012 James ZM, McCaffrey JE, Torgersen KD, Karim CB, Thomas DD. Protein-protein interactions in calcium transport regulation probed by saturation transfer electron paramagnetic resonance. Biophysical Journal. 103: 1370-8. PMID 22995510 DOI: 10.1016/j.bpj.2012.08.032  1
2012 Autry JM, Rubin JE, Svensson B, Li J, Thomas DD. Nucleotide activation of the Ca-ATPase. The Journal of Biological Chemistry. 287: 39070-82. PMID 22977248 DOI: 10.1074/jbc.M112.404434  1
2012 Colson BA, Gruber SJ, Thomas DD. Structural dynamics of muscle protein phosphorylation. Journal of Muscle Research and Cell Motility. 33: 419-29. PMID 22930331 DOI: 10.1007/s10974-012-9317-6  1
2012 Hou Z, Hu Z, Blackwell DJ, Miller TD, Thomas DD, Robia SL. 2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding. Plos One. 7: e40369. PMID 22808146 DOI: 10.1371/journal.pone.0040369  1
2012 Guhathakurta P, Prochniewicz E, Muretta JM, Titus MA, Thomas DD. Allosteric communication in Dictyostelium myosin II. Journal of Muscle Research and Cell Motility. 33: 305-12. PMID 22752265 DOI: 10.1007/s10974-012-9304-y  1
2012 Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, et al. Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes & Development. 26: 1041-54. PMID 22588718 DOI: 10.1101/gad.184325.111  1
2012 Lin AY, Prochniewicz E, Henderson DM, Li B, Ervasti JM, Thomas DD. Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design. Journal of Molecular Biology. 420: 87-98. PMID 22504225 DOI: 10.1016/j.jmb.2012.04.005  1
2012 Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. The Journal of Biological Chemistry. 287: 21265-78. PMID 22496450 DOI: 10.1074/jbc.M111.306480  1
2012 Gruber SJ, Haydon S, Thomas DD. Phospholamban mutants compete with wild type for SERCA binding in living cells Biochemical and Biophysical Research Communications. 420: 236-240. PMID 22405774 DOI: 10.1016/j.bbrc.2012.02.125  1
2012 Mello RN, Thomas DD. Three distinct actin-attached structural states of myosin in muscle fibers Biophysical Journal. 102: 1088-1096. PMID 22404931 DOI: 10.1016/j.bpj.2011.11.4027  1
2012 Li J, James ZM, Dong X, Karim CB, Thomas DD. Structural and functional dynamics of an integral membrane protein complex modulated by lipid headgroup charge. Journal of Molecular Biology. 418: 379-89. PMID 22381409 DOI: 10.1016/j.jmb.2012.02.011  1
2012 Ablorh NA, Miller T, Nitu F, Gruber SJ, Karim C, Thomas DD. Accurate quantitation of phospholamban phosphorylation by immunoblot. Analytical Biochemistry. 425: 68-75. PMID 22369895 DOI: 10.1016/j.ab.2012.01.028  1
2012 Henderson DM, Lin AY, Thomas DD, Ervasti JM. The carboxy-terminal third of dystrophin enhances actin binding activity. Journal of Molecular Biology. 416: 414-24. PMID 22226838 DOI: 10.1016/j.jmb.2011.12.040  1
2011 Espinoza-Fonseca LM, Thomas DD. Atomic-level characterization of the activation mechanism of serca by calcium Plos One. 6. PMID 22046418 DOI: 10.1371/journal.pone.0026936  1
2011 Klein JC, Moen RJ, Smith EA, Titus MA, Thomas DD. Structural and functional impact of site-directed methionine oxidation in myosin. Biochemistry. 50: 10318-27. PMID 21988699 DOI: 10.1021/bi201279u  1
2011 Prochniewicz E, Pierre A, McCullough BR, Chin HF, Cao W, Saunders LP, Thomas DD, De La Cruz EM. Actin filament dynamics in the actomyosin VI complex is regulated allosterically by calcium-calmodulin light chain. Journal of Molecular Biology. 413: 584-92. PMID 21910998 DOI: 10.1016/j.jmb.2011.08.058  1
2011 Moen RJ, Johnsrud DO, Thomas DD, Titus MA. Characterization of a myosin VII MyTH/FERM domain. Journal of Molecular Biology. 413: 17-23. PMID 21875595 DOI: 10.1016/j.jmb.2011.08.036  1
2011 Lin AY, Prochniewicz E, James ZM, Svensson B, Thomas DD. Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism. Proceedings of the National Academy of Sciences of the United States of America. 108: 12729-33. PMID 21768337 DOI: 10.1073/pnas.1106453108  1
2011 Autry JM, Rubin JE, Pietrini SD, Winters DL, Robia SL, Thomas DD. Oligomeric interactions of sarcolipin and the Ca-ATPase. The Journal of Biological Chemistry. 286: 31697-706. PMID 21737843 DOI: 10.1074/jbc.M111.246843  1
2011 Wilson DJ, Shi C, Duckworth BP, Muretta JM, Manjunatha U, Sham YY, Thomas DD, Aldrich CC. A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis. Analytical Biochemistry. 416: 27-38. PMID 21621502 DOI: 10.1016/j.ab.2011.05.003  1
2011 Lockamy EL, Cornea RL, Karim CB, Thomas DD. Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure. Biochemical and Biophysical Research Communications. 408: 388-92. PMID 21510919 DOI: 10.1016/j.bbrc.2011.04.023  1
2011 Gustavsson M, Traaseth NJ, Karim CB, Lockamy EL, Thomas DD, Veglia G. Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase. Journal of Molecular Biology. 408: 755-65. PMID 21419777 DOI: 10.1016/j.jmb.2011.03.015  1
2011 Nesmelov YE, Agafonov RV, Negrashov IV, Blakely SE, Titus MA, Thomas DD. Structural kinetics of myosin by transient time-resolved FRET. Proceedings of the National Academy of Sciences of the United States of America. 108: 1891-6. PMID 21245357 DOI: 10.1073/pnas.1012320108  1
2010 Nesmelov YE, Thomas DD. Protein structural dynamics revealed by site-directed spin labeling and multifrequency EPR. Biophysical Reviews. 2: 91-99. PMID 21687819 DOI: 10.1007/s12551-010-0032-5  0.48
2010 Muretta JM, Kyrychenko A, Ladokhin AS, Kast DJ, Gillispie GD, Thomas DD. High-performance time-resolved fluorescence by direct waveform recording. The Review of Scientific Instruments. 81: 103101. PMID 21034069 DOI: 10.1063/1.3480647  1
2010 Cornea RL, Nitu FR, Samsó M, Thomas DD, Fruen BR. Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. The Journal of Biological Chemistry. 285: 19219-26. PMID 20404344 DOI: 10.1074/jbc.M109.066944  1
2010 Prochniewicz E, Chin HF, Henn A, Hannemann DE, Olivares AO, Thomas DD, De La Cruz EM. Myosin isoform determines the conformational dynamics and cooperativity of actin filaments in the strongly bound actomyosin complex. Journal of Molecular Biology. 396: 501-9. PMID 19962990 DOI: 10.1016/j.jmb.2009.11.063  1
2009 Agafonov RV, Negrashov IV, Tkachev YV, Blakely SE, Titus MA, Thomas DD, Nesmelov YE. Structural dynamics of the myosin relay helix by time-resolved EPR and FRET. Proceedings of the National Academy of Sciences of the United States of America. 106: 21625-30. PMID 19966224 DOI: 10.1073/pnas.0909757106  1
2009 Becucci L, Guidelli R, Karim CB, Thomas DD, Veglia G. The role of sarcolipin and ATP in the transport of phosphate ion into the sarcoplasmic reticulum. Biophysical Journal. 97: 2693-9. PMID 19917222 DOI: 10.1016/j.bpj.2009.08.035  1
2009 Hermanson D, Addo SN, Bajer AA, Marchant JS, Das SG, Srinivasan B, Al-Mousa F, Michelangeli F, Thomas DD, Lebien TW, Xing C. Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria. Molecular Pharmacology. 76: 667-78. PMID 19561125 DOI: 10.1124/mol.109.055830  1
2009 Becucci L, Cembran A, Karim CB, Thomas DD, Guidelli R, Gao J, Veglia G. On the function of pentameric phospholamban: ion channel or storage form? Biophysical Journal. 96: L60-2. PMID 19450461 DOI: 10.1016/j.bpj.2009.03.013  1
2009 Prochniewicz E, Henderson D, Ervasti JM, Thomas DD. Dystrophin and utrophin have distinct effects on the structural dynamics of actin. Proceedings of the National Academy of Sciences of the United States of America. 106: 7822-7. PMID 19416869 DOI: 10.1073/pnas.0812007106  1
2009 Thomas DD, Kast D, Korman VL. Site-directed spectroscopic probes of actomyosin structural dynamics. Annual Review of Biophysics. 38: 347-69. PMID 19416073 DOI: 10.1146/annurev.biophys.35.040405.102118  1
2009 Karon BS, Hoyer JD, Stubbs JR, Thomas DD. Changes in Band 3 oligomeric state precede cell membrane phospholipid loss during blood bank storage of red blood cells. Transfusion. 49: 1435-42. PMID 19389033 DOI: 10.1111/j.1537-2995.2009.02133.x  1
2009 Ablorh NA, Nitu F, Engebretsen K, Thomas DD, Holger JS. Insulin-dependent rescue from cardiogenic shock is not mediated by phospholamban phosphorylation. Clinical Toxicology (Philadelphia, Pa.). 47: 296-302. PMID 19365773 DOI: 10.1080/15563650902870269  0.56
2009 Cornea RL, Nitu F, Gruber S, Kohler K, Satzer M, Thomas DD, Fruen BR. FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Proceedings of the National Academy of Sciences of the United States of America. 106: 6128-33. PMID 19332786 DOI: 10.1073/pnas.0813010106  1
2009 Balog EM, Lockamy EL, Thomas DD, Ferrington DA. Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry. 48: 3005-16. PMID 19231837 DOI: 10.1021/bi802117k  0.6
2008 Mahaney JE, Thomas DD, Farrance IK, Froehlich JP. Intermolecular interactions in the mechanism of skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1): evidence for a triprotomer. Biochemistry. 47: 13711-25. PMID 19046074 DOI: 10.1021/bi801024a  1
2008 Prochniewicz E, Spakowicz D, Thomas DD. Changes in actin structural transitions associated with oxidative inhibition of muscle contraction Biochemistry. 47: 11811-11817. PMID 18855423 DOI: 10.1021/bi801080x  1
2008 Thompson AR, Naber N, Wilson C, Cooke R, Thomas DD. Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2. Biophysical Journal. 95: 5238-46. PMID 18805936 DOI: 10.1529/biophysj.108.138982  0.52
2008 Agafonov RV, Nesmelov YE, Titus MA, Thomas DD. Muscle and nonmuscle myosins probed by a spin label at equivalent sites in the force-generating domain. Proceedings of the National Academy of Sciences of the United States of America. 105: 13397-402. PMID 18765799 DOI: 10.1073/pnas.0801342105  1
2008 Klein JC, Burr AR, Svensson B, Kennedy DJ, Allingham J, Titus MA, Rayment I, Thomas DD. Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR. Proceedings of the National Academy of Sciences of the United States of America. 105: 12867-72. PMID 18725645 DOI: 10.1073/pnas.0802286105  1
2008 Espinoza-Fonseca LM, Kast D, Thomas DD. Thermodynamic and structural basis of phosphorylation-induced disorder-to-order transition in the regulatory light chain of smooth muscle myosin Journal of the American Chemical Society. 130: 12208-12209. PMID 18715003 DOI: 10.1021/ja803143g  1
2008 Nesmelov YE, Agafonov RV, Burr AR, Weber RT, Thomas DD. Structure and dynamics of the force-generating domain of myosin probed by multifrequency electron paramagnetic resonance. Biophysical Journal. 95: 247-56. PMID 18339764 DOI: 10.1529/biophysj.107.124305  0.48
2008 Winters DL, Autry JM, Svensson B, Thomas DD. Interdomain fluorescence resonance energy transfer in SERCA probed by cyan-fluorescent protein fused to the actuator domain. Biochemistry. 47: 4246-56. PMID 18338856 DOI: 10.1021/bi702089j  1
2008 Prochniewicz E, Lowe DA, Spakowicz DJ, Higgins L, O'Conor K, Thompson LV, Ferrington DA, Thomas DD. Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers. American Journal of Physiology. Cell Physiology. 294: C613-26. PMID 18003749 DOI: 10.1152/ajpcell.00232.2007  1
2008 Surek JT, Thomas DD. A paramagnetic molecular voltmeter Journal of Magnetic Resonance. 190: 7-25. PMID 17964835 DOI: 10.1016/j.jmr.2007.09.020  1
2007 Robia SL, Campbell KS, Kelly EM, Hou Z, Winters DL, Thomas DD. Förster transfer recovery reveals that phospholamban exchanges slowly from pentamers but rapidly from the SERCA regulatory complex. Circulation Research. 101: 1123-9. PMID 17975108 DOI: 10.1161/CIRCRESAHA.107.159947  1
2007 Ha KN, Traaseth NJ, Verardi R, Zamoon J, Cembran A, Karim CB, Thomas DD, Veglia G. Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics. The Journal of Biological Chemistry. 282: 37205-14. PMID 17908690 DOI: 10.1074/jbc.M704056200  1
2007 Traaseth NJ, Verardi R, Torgersen KD, Karim CB, Thomas DD, Veglia G. Spectroscopic validation of the pentameric structure of phospholamban. Proceedings of the National Academy of Sciences of the United States of America. 104: 14676-81. PMID 17804809 DOI: 10.1073/pnas.0701016104  1
2007 Prochniewicz E, Thompson LV, Thomas DD. Age-related decline in actomyosin structure and function. Experimental Gerontology. 42: 931-8. PMID 17706387 DOI: 10.1016/j.exger.2007.06.015  1
2007 Galdeen SA, Stephens S, Thomas DD, Titus MA. Talin influences the dynamics of the myosin VII-membrane interaction. Molecular Biology of the Cell. 18: 4074-84. PMID 17671169 DOI: 10.1091/mbc.E06-07-0586  1
2007 Becucci L, Guidelli R, Karim CB, Thomas DD, Veglia G. An electrochemical investigation of sarcolipin reconstituted into a mercury-supported lipid bilayer. Biophysical Journal. 93: 2678-87. PMID 17586575 DOI: 10.1529/biophysj.107.109280  1
2007 Nesmelov YE, Karim CB, Song L, Fajer PG, Thomas DD. Rotational dynamics of phospholamban determined by multifrequency electron paramagnetic resonance. Biophysical Journal. 93: 2805-12. PMID 17573437 DOI: 10.1529/biophysj.107.108910  1
2007 Espinoza-Fonseca LM, Kast D, Thomas DD. Molecular dynamics simulations reveal a disorder-to-order transition on phosphorylation of smooth muscle myosin Biophysical Journal. 93: 2083-2090. PMID 17545237 DOI: 10.1529/biophysj.106.095802  1
2007 Karim CB, Zhang Z, Thomas DD. Synthesis of TOAC spin-labeled proteins and reconstitution in lipid membranes Nature Protocols. 2: 42-49. PMID 17401337 DOI: 10.1038/nprot.2007.2  1
2007 Zhang Z, Remmer HA, Thomas DD, Karim CB. Backbone dynamics determined by electron paramagnetic resonance to optimize solid-phase peptide synthesis of TOAC-labeled phospholamban. Biopolymers. 88: 29-35. PMID 17066471 DOI: 10.1002/bip.20618  0.84
2006 Lowe DA, Williams BO, Thomas DD, Grange RW. Molecular and cellular contractile dysfunction of dystrophic muscle from young mice. Muscle & Nerve. 34: 92-100. PMID 16634063 DOI: 10.1002/mus.20562  1
2006 Karim CB, Zhang Z, Howard EC, Torgersen KD, Thomas DD. Phosphorylation-dependent conformational switch in spin-labeled phospholamban bound to SERCA. Journal of Molecular Biology. 358: 1032-40. PMID 16574147 DOI: 10.1016/j.jmb.2006.02.051  1
2006 Buffy JJ, Buck-Koehntop BA, Porcelli F, Traaseth NJ, Thomas DD, Veglia G. Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy. Journal of Molecular Biology. 358: 420-9. PMID 16519897 DOI: 10.1016/j.jmb.2006.02.005  1
2006 Zhang J, Wallar BJ, Popescu CV, Renner DB, Thomas DD, Lipscomb JD. Methane monooxygenase hydroxylase and B component interactions. Biochemistry. 45: 2913-26. PMID 16503646 DOI: 10.1021/bi052256t  1
2006 Traverse JH, Nesmelov YE, Crampton M, Lindstrom P, Thomas DD, Bache RJ. Measurement of myocardial free radical production during exercise using EPR spectroscopy. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2453-8. PMID 16415082 DOI: 10.1152/ajpheart.00412.2005  0.48
2006 Korman VL, Anderson SE, Prochniewicz E, Titus MA, Thomas DD. Structural dynamics of the actin-myosin interface by site-directed spectroscopy. Journal of Molecular Biology. 356: 1107-17. PMID 16406406 DOI: 10.1016/j.jmb.2005.10.024  1
2005 Prochniewicz E, Janson N, Thomas DD, De la Cruz EM. Cofilin increases the torsional flexibility and dynamics of actin filaments. Journal of Molecular Biology. 353: 990-1000. PMID 16213521 DOI: 10.1016/j.jmb.2005.09.021  1
2005 Prochniewicz E, Thomas DD, Thompson LV. Age-related decline in actomyosin function. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 60: 425-31. PMID 15933379  1
2005 Robia SL, Flohr NC, Thomas DD. Phospholamban pentamer quaternary conformation determined by in-gel fluorescence anisotropy. Biochemistry. 44: 4302-11. PMID 15766259 DOI: 10.1021/bi0478446  1
2005 Paterlini MG, Thomas DD. The α-helical propensity of the cytoplasmic domain of phospholamban: A molecular dynamics simulation of the effect of phosphorylation and mutation Biophysical Journal. 88: 3243-3251. PMID 15764655 DOI: 10.1529/biophysj.104.054460  1
2005 Nelson WD, Blakely SE, Nesmelov YE, Thomas DD. Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin Proceedings of the National Academy of Sciences of the United States of America. 102: 4000-4005. PMID 15753305 DOI: 10.1073/pnas.0401664102  1
2005 Fruen BR, Balog EM, Schafer J, Nitu FR, Thomas DD, Cornea RL. Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin. Biochemistry. 44: 278-84. PMID 15628869 DOI: 10.1021/bi048246u  1
2004 Karim CB, Kirby TL, Zhang Z, Nesmelov Y, Thomas DD. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proceedings of the National Academy of Sciences of the United States of America. 101: 14437-42. PMID 15448204 DOI: 10.1073/pnas.0402801101  0.84
2004 Prochniewicz E, Walseth TF, Thomas DD. Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. Biochemistry. 43: 10642-52. PMID 15311925 DOI: 10.1021/bi049914e  1
2004 Metcalfe EE, Zamoon J, Thomas DD, Veglia G. (1)H/(15)N heteronuclear NMR spectroscopy shows four dynamic domains for phospholamban reconstituted in dodecylphosphocholine micelles. Biophysical Journal. 87: 1205-14. PMID 15298923 DOI: 10.1529/biophysj.103.038844  1
2004 Mueller B, Karim CB, Negrashov IV, Kutchai H, Thomas DD. Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer. Biochemistry. 43: 8754-65. PMID 15236584 DOI: 10.1021/bi049732k  0.84
2004 Kirby TL, Karim CB, Thomas DD. Electron Paramagnetic Resonance Reveals a Large-Scale Conformational Change in the Cytoplasmic Domain of Phospholamban upon Binding to the Sarcoplasmic Reticulum Ca-ATPase Biochemistry. 43: 5842-5852. PMID 15134458 DOI: 10.1021/bi035749b  1
2004 Mahaney JE, Thomas DD, Froehlich JP. The time-dependent distribution of phosphorylated intermediates in native sarcoplasmic reticulum Ca2+-ATPase from skeletal muscle is not compatible with a linear kinetic model. Biochemistry. 43: 4400-16. PMID 15065885 DOI: 10.1021/bi035068g  1
2004 Lowe DA, Warren GL, Snow LM, Thompson LV, Thomas DD. Muscle activity and aging affect myosin structural distribution and force generation in rat fibers. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 498-506. PMID 14514706 DOI: 10.1152/japplphysiol.00842.2003  1
2003 Zamoon J, Mascioni A, Thomas DD, Veglia G. NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles. Biophysical Journal. 85: 2589-98. PMID 14507721 DOI: 10.1016/S0006-3495(03)74681-5  1
2003 LaConte LE, Baker JE, Thomas DD. Transient kinetics and mechanics of myosin's force-generating rotation in muscle: resolution of millisecond rotational transitions in the spin-labeled myosin light-chain domain. Biochemistry. 42: 9797-803. PMID 12911323 DOI: 10.1021/bi034288r  0.44
2003 Reddy LG, Cornea RL, Winters DL, McKenna E, Thomas DD. Defining the molecular components of calcium transport regulation in a reconstituted membrane system. Biochemistry. 42: 4585-92. PMID 12693956 DOI: 10.1021/bi026995a  1
2003 Balog EM, Norton LE, Bloomquist RA, Cornea RL, Black DJ, Louis CF, Thomas DD, Fruen BR. Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1. The Journal of Biological Chemistry. 278: 15615-21. PMID 12586832 DOI: 10.1074/jbc.M209180200  1
2002 Lidke DS, Thomas DD. Coordination of the two heads of myosin during muscle contraction. Proceedings of the National Academy of Sciences of the United States of America. 99: 14801-6. PMID 12417762 DOI: 10.1073/pnas.232161999  1
2002 LaConte LE, Voelz V, Nelson W, Enz M, Thomas DD. Molecular dynamics simulation of site-directed spin labeling: experimental validation in muscle fibers. Biophysical Journal. 83: 1854-66. PMID 12324407 DOI: 10.1016/S0006-3495(02)73950-7  0.44
2002 Lowe DA, Thomas DD, Thompson LV. Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers. American Journal of Physiology. Cell Physiology. 283: C187-92. PMID 12055087 DOI: 10.1152/ajpcell.00008.2002  1
2002 Thomas DD, Prochniewicz E, Roopnarine O. Changes in actin and myosin structural dynamics due to their weak and strong interactions. Results and Problems in Cell Differentiation. 36: 7-19. PMID 11892285  1
2002 Mascioni A, Karim C, Barany G, Thomas DD, Veglia G. Structure and orientation of sarcolipin in lipid environments. Biochemistry. 41: 475-82. PMID 11781085 DOI: 10.1021/bi011243m  1
2001 Prochniewicz E, Thomas DD. Site-specific mutations in the myosin binding sites of actin affect structural transitions that control myosin binding Biochemistry. 40: 13933-13940. PMID 11705383 DOI: 10.1021/bi010893n  1
2001 Nesmelov YE, Surek JT, Thomas DD. Enhanced EPR sensitivity from a ferroelectric cavity insert Journal of Magnetic Resonance. 153: 7-14. PMID 11700076 DOI: 10.1006/jmre.2001.2415  1
2001 Karim CB, Paterlini MG, Reddy LG, Hunter GW, Barany G, Thomas DD. Role of cysteine residues in structural stability and function of a transmembrane helix bundle. The Journal of Biological Chemistry. 276: 38814-9. PMID 11477077 DOI: 10.1074/jbc.M104006200  1
2001 Hellstern S, Pegoraro S, Karim CB, Lustig A, Thomas DD, Moroder L, Engel J. Sarcolipin, the shorter homologue of phospholamban, forms oligomeric structures in detergent micelles and in liposomes. The Journal of Biological Chemistry. 276: 30845-52. PMID 11413134 DOI: 10.1074/jbc.M102495200  0.84
2001 Orlova A, Rybakova IN, Prochniewicz E, Thomas DD, Ervasti JM, Egelman EH. Binding of dystrophin's tandem calponin homology domain to F-actin is modulated by actin's structure. Biophysical Journal. 80: 1926-31. PMID 11259305 DOI: 10.1016/S0006-3495(01)76162-0  1
2001 Thompson LV, Lowe DA, Ferrington DA, Thomas DD. Electron paramagnetic resonance: A high-resolution tool for muscle physiology Exercise and Sport Sciences Reviews. 29: 3-6. PMID 11210444  1
2001 Lowe DA, Surer JT, Thomas DD, Thompson LV. Electron paramagnetic resonance reveals age-related myosin structural changes in rat skeletal muscle fibers American Journal of Physiology - Cell Physiology. 280. PMID 11171573  1
2000 Baker JE, LaConte LE, Thomas DD, Brust-Mascher I. Muscle chemistry and force. Biophysical Journal. 79: 1687-8. PMID 11041630 DOI: 10.1016/S0006-3495(00)76419-8  0.44
2000 Baker JE, Thomas DD. A thermodynamic muscle model and a chemical basis for A.V. Hill's muscle equation Journal of Muscle Research and Cell Motility. 21: 335-344. PMID 11032344 DOI: 10.1023/A:1005615925390  1
1999 Prochniewicz E, Thomas DD. Differences in structural dynamics of muscle and yeast actin accompany differences in functional interactions with myosin Biochemistry. 38: 14860-14867. PMID 10555968 DOI: 10.1021/bi991343g  1
1999 Baker JE, LaConte LE, Brust-Mascher I, Thomas DD. Mechanochemical coupling in spin-labeled, active, isometric muscle. Biophysical Journal. 77: 2657-64. PMID 10545366 DOI: 10.1016/S0006-3495(99)77100-6  0.44
1999 Brust-Mascher I, LaConte LE, Baker JE, Thomas DD. Myosin light-chain domain rotates upon muscle activation but not ATP hydrolysis. Biochemistry. 38: 12607-13. PMID 10504229 DOI: 10.1021/BI9905967  0.44
1999 Ramachandran S, Thomas DD. Rotational dynamics of the regulatory light chain in scallop muscle detected by time-resolved phosphorescence anisotropy Biochemistry. 38: 9097-9104. PMID 10413484 DOI: 10.1021/bi9902945  1
1998 Roopnarine O, Szent-Györgyi AG, Thomas DD. Microsecond rotational dynamics of spin-labeled myosin regulatory light chain induced by relaxation and contraction of scallop muscle. Biochemistry. 37: 14428-36. PMID 9772169 DOI: 10.1021/bi9808363  1
1998 Baker JE, Brust-Mascher I, Ramachandran S, LaConte LE, Thomas DD. A large and distinct rotation of the myosin light chain domain occurs upon muscle contraction. Proceedings of the National Academy of Sciences of the United States of America. 95: 2944-9. PMID 9501195 DOI: 10.1073/pnas.95.6.2944  0.44
1997 Prochniewicz E, Thomas DD. Perturbations of functional interactions with myosin induce long-range allosteric and cooperative structural changes in actin Biochemistry. 36: 12845-12853. PMID 9335542 DOI: 10.1021/bi971201r  1
1996 Roopnarine O, Thomas DD. Orientation of intermediate nucleotide states of indane dione spin-labeled myosin heads in muscle fibers. Biophysical Journal. 70: 2795-806. PMID 8744317 DOI: 10.1016/S0006-3495(96)79849-1  1
1996 Prochniewicz E, Zhang Q, Janmey PA, Thomas DD. Cooperativity in F-actin: Binding of gelsolin at the barbed end affects structure and dynamics of the whole filament Journal of Molecular Biology. 260: 756-766. PMID 8709153 DOI: 10.1006/jmbi.1996.0435  1
1996 Prochniewicz E, Zhang Q, Howard EC, Thomas DD. Microsecond rotational dynamics of actin: spectroscopic detection and theoretical simulation. Journal of Molecular Biology. 255: 446-57. PMID 8568889 DOI: 10.1006/jmbi.1996.0037  1
1995 Thomas DD, Ramachandran S, Roopnarine O, Hayden DW, Ostap EM, Rayment I, Reisler K, Kinosita K. The mechanism of force generation in myosin: A disorder-to-order transition, coupled to internal structural changes Biophysical Journal. 68: 135s-141s. PMID 7787056  1
1995 Roopnarine O, Thomas DD. Orientational dynamics of indane dione spin-labeled myosin heads in relaxed and contracting skeletal muscle fibers. Biophysical Journal. 68: 1461-71. PMID 7787032 DOI: 10.1016/S0006-3495(95)80319-X  1
1995 Ostap EM, Barnett VA, Thomas DD. Resolution of three structural states of spin-labeled myosin in contracting muscle. Biophysical Journal. 69: 177-88. PMID 7669895 DOI: 10.1016/S0006-3495(95)79888-5  1
1994 Berger CL, Thomas DD. Rotational dynamics of actin-bound intermediates of the myosin adenosine triphosphatase cycle in myofibrils. Biophysical Journal. 67: 250-61. PMID 7918993 DOI: 10.1016/S0006-3495(94)80476-X  1
1994 Roopnarine O, Thomas DD. A spin label that binds to myosin heads in muscle fibers with its principal axis parallel to the fiber axis. Biophysical Journal. 67: 1634-45. PMID 7819495 DOI: 10.1016/S0006-3495(94)80636-8  1
1993 Roopnarine O, Hideg K, Thomas DD. Saturation transfer electron parametric resonance of an indane-dione spin-label. Calibration with hemoglobin and application to myosin rotational dynamics. Biophysical Journal. 64: 1896-907. PMID 8396449 DOI: 10.1016/S0006-3495(93)81561-3  1
1993 Ostap EM, White HD, Thomas DD. Transient detection of spin-labeled myosin subfragment 1 conformational states during ATP hydrolysis. Biochemistry. 32: 6712-20. PMID 8392368  1
1993 Berger CL, Thomas DD. Rotational dynamics of actin-bound myosin heads in active myofibrils. Biochemistry. 32: 3812-21. PMID 8385491  1
1993 Thomas DD. Pollard to actomyosin: 'Freeze! Don't even move your head' Biophysical Journal. 64: 297-298. PMID 8384499  1
1993 Prochniewicz E, Katayama E, Yanagida T, Thomas DD. Cooperativity in F-actin: Chemical modifications of actin monomers affect the functional interactions of myosin with unmodified monomers in the same actin filament Biophysical Journal. 65: 113-123. PMID 8369420  1
1993 Naber N, Ostap EM, Thomas DD, Cooke R. Orientation and rotational dynamics of spin-labeled phalloidin bound to actin in muscle fibers. Proteins. 17: 347-54. PMID 8108377 DOI: 10.1002/prot.340170403  1
1992 Tanner JW, Thomas DD, Goldman YE. Transients in orientation of a fluorescent cross-bridge probe following photolysis of caged nucleotides in skeletal muscle fibres. Journal of Molecular Biology. 223: 185-203. PMID 1530978 DOI: 10.1016/0022-2836(92)90725-Y  1
1992 Ostap EM, Yanagida T, Thomas DD. Orientational distribution of spin-labeled actin oriented by flow. Biophysical Journal. 63: 966-75. PMID 1330042 DOI: 10.1016/S0006-3495(92)81684-3  1
1992 Alessi DR, Corrie JE, Fajer PG, Ferenczi MA, Thomas DD, Trayer IP, Trentham DR. Synthesis and properties of a conformationally restricted spin-labeled analog of ATP and its interaction with myosin and skeletal muscle. Biochemistry. 31: 8043-54. PMID 1324724  1
1991 Fajer PG, Fajer EA, Schoenberg M, Thomas DD. Orientational disorder and motion of weakly attached cross-bridges Biophysical Journal. 60: 642-649. PMID 1657230  1
1991 Ostap EM, Thomas DD. Rotational dynamics of spin-labeled F-actin during activation of myosin S1 ATPase using caged ATP. Biophysical Journal. 59: 1235-41. PMID 1651780 DOI: 10.1016/S0006-3495(91)82338-4  1
1990 Fajer PG, Fajer EA, Thomas DD. Myosin heads have a broad orientational distribution during isometric muscle contraction: Time-resolved EPR studies using caged ATP Proceedings of the National Academy of Sciences of the United States of America. 87: 5538-5542. PMID 2164688  1
1990 Stein RA, Ludescher RD, Dahlberg PS, Fajer PG, Bennett RL, Thomas DD. Time-resolved rotational dynamics of phosphorescent-labeled myosin heads in contracting muscle fibers. Biochemistry. 29: 10023-31. PMID 1703000  1
1989 Berger CL, Svensson EC, Thomas DD. Photolysis of a photolabile precursor of ATP (caged ATP) induces microsecond rotational motions of myosin heads bound to actin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8753-7. PMID 2554328 DOI: 10.1073/pnas.86.22.8753  1
1989 Barnett VA, Thomas DD. Microsecond rotational motion of spin-labeled myosin heads during isometric muscle contraction. Saturation transfer electron paramagnetic resonance. Biophysical Journal. 56: 517-23. PMID 2551405 DOI: 10.1016/S0006-3495(89)82698-0  1
1988 Thomas DD, Fajer PG, Fajer EA, Brunsvold NJ, Svensson EC. EPR evidence for nucleotide effects on attached cross-bridges Advances in Experimental Medicine and Biology. 226: 241-253. PMID 2841826  1
1988 Fajer PG, Fajer EA, Brunsvold NJ, Thomas DD. Effects of AMPPNP on the orientation and rotational dynamics of spin-labeled muscle cross-bridges Biophysical Journal. 53: 513-524. PMID 2838098  1
1988 Ludescher RD, Thomas DD. Microsecond rotational dynamics of phosphorescent-labeled muscle cross-bridges. Biochemistry. 27: 3343-51. PMID 2455541 DOI: 10.1021/bi00409a034  1
1988 Ludescher RD, Eads TM, Thomas DD. Ionic effects on the rotational dynamics of cross-bridges in myosin filaments, measured by triplet absorption anisotropy. Journal of Molecular Biology. 200: 89-99. PMID 2454317 DOI: 10.1016/0022-2836(88)90335-X  1
1987 Thomas DD. Spectroscopic probes of muscle cross-bridge rotation Annual Review of Physiology. 49: 691-709. PMID 3032079  1
1987 Barnett VA, Thomas DD. Resolution of conformational states of spin-labeled myosin during steady-state ATP hydrolysis. Biochemistry. 26: 314-23. PMID 3030402  1
1986 Svensson EC, Thomas DD. ATP induces microsecond rotational motions of myosin heads crosslinked to actin Biophysical Journal. 50: 999-1002. PMID 3790699 DOI: 10.1016/S0006-3495(86)83541-X  1
1984 Eads TM, Thomas DD, Austin RH. Microsecond rotational motions of eosin-labeled myosin measured by time-resolved anisotropy of absorption and phosphorescence. Journal of Molecular Biology. 179: 55-81. PMID 6209402 DOI: 10.1016/0022-2836(84)90306-1  1
1984 Barnett VA, Thomas DD. Saturation transfer electron paramagnetic resonance of spin-labeled muscle fibers. Dependence of myosin head rotational motion on sarcomere length. Journal of Molecular Biology. 179: 83-102. PMID 6094826 DOI: 10.1016/0022-2836(84)90307-3  1
1982 Stryer L, Thomas DD, Carlsen WF. Fluorescence energy transfer measurements of distances in rhodopsin and the purple membrane protein. Methods in Enzymology. 81: 668-78. PMID 7098907 DOI: 10.1016/S0076-6879(82)81092-6  1
1982 Thomas DD, Stryer L. Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes. Journal of Molecular Biology. 154: 145-57. PMID 7077659 DOI: 10.1016/0022-2836(82)90422-3  1
1982 Stryer L, Thomas DD, Meares CF. Diffusion-enhanced fluorescence energy transfer. Annual Review of Biophysics and Bioengineering. 11: 203-22. PMID 7049062 DOI: 10.1146/annurev.bb.11.060182.001223  1
1982 Cooke R, Crowder MS, Thomas DD. Orientation of spin labels attached to cross-bridges in contracting muscle fibres Nature. 300: 776-778. PMID 6294531 DOI: 10.1038/300776a0  1
1980 Thomas DD, Cooke R. Orientation of spin-labeled myosin heads in glycerinated muscle fibers Biophysical Journal. 32: 891-906. PMID 6266539  1
1980 Thomas DD, Ishiwata S, Seidel JC, Gergely J. Submillisecond rotational dynamics of spin-labeled myosin heads in myofibrils Biophysical Journal. 32: 873-889. PMID 6266538  1
1979 Thomas DD, Seidel JC, Gergely J. Rotational dynamics of spin-labeled F-actin in the sub-millisecond time range Journal of Molecular Biology. 132: 257-273. PMID 230351 DOI: 10.1016/0022-2836(79)90259-6  1
1978 Thomas DD, Carlsen WF, Stryer L. Fluorescence energy transfer in the rapid-diffusion limit. Proceedings of the National Academy of Sciences of the United States of America. 75: 5746-50. PMID 16592590  1
1978 Thomas DD. Large-scale rotational motions of proteins detected by electron paramagnetic resonance and fluorescence Biophysical Journal. 24: 439-462. PMID 215240  1
1975 Thomas DD, Seidel JC, Gergely J, Hyde JS. The quantitative measurement of rotational motion of the subfragment-1 region of myosin by saturation transfer epr spectroscopy. Journal of Supramolecular Structure. 3: 376-90. PMID 172739 DOI: 10.1002/jss.400030410  1
1975 Thomas DD, Seidel JC, Hyde JS, Gergely J. Motion of subfragment-1 in myosin and its supramolecular complexes: saturation transfer electron paramagnetic resonance. Proceedings of the National Academy of Sciences of the United States of America. 72: 1729-33. PMID 168572  1
1965 McConnell HM, Hoffman BM, Thomas DD, Gamble FR. CHEMICAL ENHANCEMENT OF SUPERCONDUCTIVITY. Proceedings of the National Academy of Sciences of the United States of America. 54: 371-4. PMID 16591299  0.84
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