Stefan Nikolaus Gradl - Publications

Affiliations: 
2005 University of California, Berkeley, Berkeley, CA 

11 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Zak M, Hurley CA, Ward SI, Bergeron P, Barrett K, Balazs M, Blair WS, Bull R, Chakravarty P, Chang C, Crackett P, Deshmukh G, DeVoss J, Dragovich PS, Eigenbrot C, ... ... Gradl S, et al. Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. Journal of Medicinal Chemistry. 56: 4764-85. PMID 23659214 DOI: 10.1021/jm4004895  1
2013 Musshoff F, Wolters T, Lott S, Ippisch J, Gradl S, Madea B. Optimization and validation of CEDIA drugs of abuse immunoassay tests in serum and urine on an Olympus AU 400. Drug Testing and Analysis. 5: 366-71. PMID 23386567 DOI: 10.1002/dta.1454  1
2012 Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, et al. Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2. Journal of Medicinal Chemistry. 55: 6176-93. PMID 22698084 DOI: 10.1021/jm300628c  1
2012 Mathieu S, Gradl SN, Ren L, Wen Z, Aliagas I, Gunzner-Toste J, Lee W, Pulk R, Zhao G, Alicke B, Boggs JW, Buckmelter AJ, Choo EF, Dinkel V, Gloor SL, et al. Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. Journal of Medicinal Chemistry. 55: 2869-81. PMID 22335519 DOI: 10.1021/jm300016v  1
2012 Ren L, Laird ER, Buckmelter AJ, Dinkel V, Gloor SL, Grina J, Newhouse B, Rasor K, Hastings G, Gradl SN, Rudolph J. Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties Bioorganic and Medicinal Chemistry Letters. 22: 1165-1168. PMID 22196124 DOI: 10.1016/j.bmcl.2011.11.092  1
2011 Wenglowsky S, Ahrendt KA, Buckmelter AJ, Feng B, Gloor SL, Gradl S, Grina J, Hansen JD, Laird ER, Lunghofer P, Mathieu S, Moreno D, Newhouse B, Ren L, Risom T, et al. Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. 21: 5533-7. PMID 21802293 DOI: 10.1016/j.bmcl.2011.06.097  1
2007 Gradl SN, Trauner D. The Meerwein-Eschenmoser-Claisen Rearrangement The Claisen Rearrangement: Methods and Applications. 367-396. DOI: 10.1002/9783527610549.ch7  1
2006 Miller AK, Hughes CC, Kennedy-Smith JJ, Gradl SN, Trauner D. Total synthesis of (-)-heptemerone B and (-)-guanacastepene E. Journal of the American Chemical Society. 128: 17057-62. PMID 17177458 DOI: 10.1021/ja0660507  1
2003 Liang G, Gradl SN, Trauner D. Efficient Nazarov cyclizations of 2-alkoxy-1,4-pentadien-3-ones. Organic Letters. 5: 4931-4. PMID 14682732 DOI: 10.1021/ol036019z  1
2003 Gradl SN, Felix JP, Isacoff EY, Garcia ML, Trauner D. Protein surface recognition by rational design: nanomolar ligands for potassium channels. Journal of the American Chemical Society. 125: 12668-9. PMID 14558789 DOI: 10.1021/ja036155z  1
2002 Gradl SN, Kennedy-Smith JJ, Kim J, Trauner D. A practical variant of the Claisen-Eschenmoser rearrangement: Synthesis of unsaturated morpholine amides Synlett. 411-414.  1
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