| Year |
Citation |
Score |
| 2019 |
Collie GW, Koh CM, O'Neill DJ, Stubbs CJ, Khurana P, Eddershaw A, Snijder A, Mauritzson F, Barlind L, Dale IL, Shaw J, Phillips C, Hennessy EJ, Cheung T, Narvaez AJ. Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors. Acs Medicinal Chemistry Letters. 10: 1322-1327. PMID 31531204 DOI: 10.1021/Acsmedchemlett.9B00276 |
0.335 |
|
| 2018 |
Cidado J, Secrist JP, Gibbons FD, Hennessy EJ, Ioannidis S, Clark EA. Abstract 311: AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models Cancer Research. 78: 311-311. DOI: 10.1158/1538-7445.Am2018-311 |
0.314 |
|
| 2017 |
Hennessy EJ, Cornebise M, Gingipalli L, Grebe T, Hande S, Hoesch V, Huynh H, Throner S, Varnes J, Wu Y. Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling Tetrahedron Letters. 58: 1709-1713. DOI: 10.1016/J.Tetlet.2017.03.056 |
0.396 |
|
| 2016 |
McCoull W, Hennessy EJ, Blades K, Chuaqui C, Dowling JE, Ferguson AD, Goldberg FW, Howe N, Jones CR, Kemmitt PD, Lamont G, Varnes JG, Ward RA, Yang B. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. Acs Medicinal Chemistry Letters. 7: 1118-1123. PMID 27994749 DOI: 10.1021/Acsmedchemlett.6B00322 |
0.377 |
|
| 2016 |
Hennessy EJ, Chuaqui C, Ashton S, Colclough N, Cross DA, Debreczeni JÉ, Eberlein C, Gingipalli L, Klinowska TC, Orme JP, Sha L, Wu X. Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation. Acs Medicinal Chemistry Letters. 7: 514-519. PMID 27190603 DOI: 10.1021/Acsmedchemlett.6B00058 |
0.335 |
|
| 2016 |
Hennessy EJ. Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity. Bioorganic & Medicinal Chemistry Letters. PMID 26988306 DOI: 10.1016/J.Bmcl.2016.03.032 |
0.361 |
|
| 2015 |
Hennessy EJ, Oza V, Adam A, Byth K, Castriotta L, Grewal G, Hamilton GA, Kamhi VM, Lewis P, Li D, Lyne P, Öster L, Rooney MT, Saeh JC, Sha L, et al. Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity. Journal of Medicinal Chemistry. 58: 7057-75. PMID 26291341 DOI: 10.1021/Acs.Jmedchem.5B01078 |
0.363 |
|
| 2015 |
Hird AW, Aquila BM, Hennessy EJ, Vasbinder MM, Yang B. Small molecule inhibitor of apoptosis proteins antagonists: a patent review. Expert Opinion On Therapeutic Patents. 25: 755-74. PMID 25980951 DOI: 10.1517/13543776.2015.1041922 |
0.309 |
|
| 2015 |
Hennessy EJ, Grewal G, Byth K, Kamhi VM, Li D, Lyne P, Oza V, Ronco L, Rooney MT, Saeh JC, Su Q. Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 2041-5. PMID 25890801 DOI: 10.1016/J.Bmcl.2015.03.095 |
0.359 |
|
| 2014 |
Yang B, Lamb ML, Zhang T, Hennessy EJ, Grewal G, Sha L, Zambrowski M, Block MH, Dowling JE, Su N, Wu J, Deegan T, Mikule K, Wang W, Kaspera R, et al. Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening. Journal of Medicinal Chemistry. 57: 9958-70. PMID 25458601 DOI: 10.1021/Jm501179R |
0.406 |
|
| 2014 |
Hird AW, Aquila BM, Block MH, Hennessy EJ, Kamhi VM, Omer CA, Laing NM, Saeh JC, Sha L, Yang B. Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 1820-4. PMID 24631189 DOI: 10.1016/J.Bmcl.2014.02.016 |
0.441 |
|
| 2014 |
McCoull W, Hennessy EJ, Blades K, Box MR, Chuaqui C, Dowling JE, Davies CD, Ferguson AD, Goldberg FW, Howe NJ, Kemmitt PD, Lamont GM, Madden K, McWhirter C, Varnes JG, et al. Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity Medchemcomm. 5: 1533-1539. DOI: 10.1039/C4Md00280F |
0.37 |
|
| 2013 |
Hennessy EJ, Adam A, Aquila BM, Castriotta LM, Cook D, Hattersley M, Hird AW, Huntington C, Kamhi VM, Laing NM, Li D, MacIntyre T, Omer CA, Oza V, Patterson T, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). Journal of Medicinal Chemistry. 56: 9897-919. PMID 24320998 DOI: 10.1021/Jm401075X |
0.372 |
|
| 2013 |
Vasbinder MM, Aquila B, Augustin M, Chen H, Cheung T, Cook D, Drew L, Fauber BP, Glossop S, Grondine M, Hennessy E, Johannes J, Lee S, Lyne P, Mörtl M, et al. Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors. Journal of Medicinal Chemistry. 56: 1996-2015. PMID 23398453 DOI: 10.1021/Jm301658D |
0.346 |
|
| 2013 |
Saeh JC, Aquila B, Russell D, Hennessy E, Hird A, Vasbinder M, Ferguson A, Yang B, Hattersley M, Laing N, MacIntyre T, Patterson T, Repik G, Rooney M, Wang H, et al. Abstract B100: Structure-based design of AZ7732 a novel in vivo active beta-alanine-derived pan-IAP inhibitor. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B100 |
0.386 |
|
| 2012 |
Hennessy EJ, Saeh JC, Sha L, MacIntyre T, Wang H, Larsen NA, Aquila BM, Ferguson AD, Laing NM, Omer CA. Discovery of aminopiperidine-based Smac mimetics as IAP antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 1690-4. PMID 22264476 DOI: 10.1016/J.Bmcl.2011.12.109 |
0.41 |
|
| 2008 |
Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America. 105: 7159-64. PMID 18480256 DOI: 10.1073/Pnas.0801934105 |
0.425 |
|
| 2005 |
Hennessy EJ, Buchwald SL. Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination. The Journal of Organic Chemistry. 70: 7371-5. PMID 16122261 DOI: 10.1021/Jo051096O |
0.49 |
|
| 2004 |
Hennessy EJ, Buchwald SL. Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C—H Functionalization. Cheminform. 35. DOI: 10.1002/chin.200404090 |
0.388 |
|
| 2003 |
Hennessy EJ, Buchwald SL. Synthesis of substituted oxindoles from alpha-chloroacetanilides via palladium-catalyzed C[bond]H functionalization. Journal of the American Chemical Society. 125: 12084-5. PMID 14518981 DOI: 10.1021/Ja037546G |
0.48 |
|
| 2002 |
Hennessy EJ, Buchwald SL. A general and mild copper-catalyzed arylation of diethyl malonate. Organic Letters. 4: 269-72. PMID 11796067 DOI: 10.1021/Ol017038G |
0.457 |
|
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