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Wayne Chou - Publications

Affiliations: 
2008- Chemistry Brown University, Providence, RI 
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Blank PN, Harris GG, Chou WKW, Duan L, Cane DE, Christianson DW. Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry. PMID 28967743 DOI: 10.1021/Acs.Biochem.7B00895  0.503
2017 Pemberton TA, Chen M, Harris GG, Chou WK, Duan L, Köksal M, Genshaft AS, Cane DE, Christianson DW. Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry. PMID 28362483 DOI: 10.1021/Acs.Biochem.7B00137  0.459
2017 Chou WK, Gould CA, Cane DE. Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate. The Journal of Antibiotics. PMID 28246382 DOI: 10.1038/Ja.2017.24  0.474
2016 Li Z, Gao R, Hao Q, Zhao H, Cheng L, He F, Liu L, Liu X, Chou WK, Zhu H, Cane DE. The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene. Biochemistry. 55: 6599-6604. PMID 27933789 DOI: 10.1021/Acs.Biochem.6B01004  0.454
2016 Chen M, Chou WK, Al-Lami N, Faraldos JA, Allemann RK, Cane DE, Christianson DW. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry. PMID 27172425 DOI: 10.1021/Acs.Biochem.6B00343  0.47
2016 Chen M, Chou WK, Toyomasu T, Cane DE, Christianson DW. Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. Acs Chemical Biology. PMID 26734760 DOI: 10.1021/Acschembio.5B00960  0.507
2015 Harris GG, Lombardi PM, Pemberton TA, Matsui T, Weiss TM, Cole KE, Köksal M, Murphy FV, Vedula LS, Chou WK, Cane DE, Christianson DW. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry. PMID 26598179 DOI: 10.1021/Acs.Biochem.5B01143  0.473
2014 Li R, Chou WK, Himmelberger JA, Litwin KM, Harris GG, Cane DE, Christianson DW. Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase. Biochemistry. 53: 1155-68. PMID 24517311 DOI: 10.1021/Bi401643U  0.519
2013 Köksal M, Chou WK, Cane DE, Christianson DW. Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase. Biochemistry. 52: 5247-55. PMID 23844678 DOI: 10.1021/Bi400797C  0.527
2012 Köksal M, Chou WK, Cane DE, Christianson DW. Structure of 2-methylisoborneol synthase from Streptomyces coelicolor and implications for the cyclization of a noncanonical C-methylated monoterpenoid substrate. Biochemistry. 51: 3011-20. PMID 22455514 DOI: 10.1021/Bi201827A  0.508
2012 Köksal M, Chou WK, Cane DE, Christianson DW. Structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification. Biochemistry. 51: 3003-10. PMID 22455498 DOI: 10.1021/Bi300109C  0.506
2011 Chou WK, Ikeda H, Cane DE. Cloning and characterization of Pfl_1841, a 2-methylenebornane synthase in Pseudomonas fluorescens PfO-1. Tetrahedron. 67: 6627-6632. PMID 21804650 DOI: 10.1016/J.Tet.2011.05.084  0.485
2011 Hu Y, Chou WK, Hopson R, Cane DE. Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases. Chemistry & Biology. 18: 32-7. PMID 21276937 DOI: 10.1016/J.Chembiol.2010.11.008  0.577
2011 Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT. Biosynthesis of 2-methylisoborneol in cyanobacteria. Environmental Science & Technology. 45: 992-8. PMID 21174459 DOI: 10.1021/Es102992P  0.473
2010 Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. Journal of the American Chemical Society. 132: 8850-1. PMID 20536237 DOI: 10.1021/Ja103087W  0.514
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