Year |
Citation |
Score |
2024 |
Mazzaferro S, Kang G, Natarajan K, Hibbs RE, Sine SM. Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. British Journal of Pharmacology. PMID 38454578 DOI: 10.1111/bph.16321 |
0.307 |
|
2024 |
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE. Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. Cell. 187: 1160-1176.e21. PMID 38382524 DOI: 10.1016/j.cell.2024.01.032 |
0.415 |
|
2022 |
Mazzaferro S, Msekela DJ, Cooper EC, Maheshwari A, Sine SM. Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening. International Journal of Molecular Sciences. 23. PMID 36292983 DOI: 10.3390/ijms232012124 |
0.381 |
|
2021 |
Mazzaferro S, Strikwerda JR, Sine SM. Stoichiometry-selective modulation of α4β2 nicotinic acetylcholine receptors by divalent cations. British Journal of Pharmacology. PMID 34768309 DOI: 10.1111/bph.15723 |
0.327 |
|
2021 |
Strikwerda JR, Sine SM. Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor. Elife. 10. PMID 33821794 DOI: 10.7554/eLife.66225 |
0.337 |
|
2021 |
Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell. PMID 33735609 DOI: 10.1016/j.cell.2021.02.049 |
0.732 |
|
2020 |
Natarajan K, Mukhtasimova N, Corradi J, Lasala M, Bouzat C, Sine SM. Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor. The Journal of General Physiology. 152. PMID 32702089 DOI: 10.1085/Jgp.202012606 |
0.463 |
|
2020 |
Mazzaferro S, Whiteman ST, Alcaino C, Beyder A, Sine SM. NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor. Cellular and Molecular Life Sciences : Cmls. PMID 32676916 DOI: 10.1007/S00018-020-03592-X |
0.409 |
|
2020 |
Shen XM, Di L, Shen S, Zhao Y, Neumeyer AM, Selcen D, Sine SM, Engel AG. A novel fast-channel myasthenia caused by mutation in β subunit of AChR reveals subunit-specific contribution of the intracellular M1-M2 linker to channel gating. Experimental Neurology. 113375. PMID 32504635 DOI: 10.1016/J.Expneurol.2020.113375 |
0.458 |
|
2019 |
Shen XM, Milone M, Wang HL, Banwell B, Selcen D, Sine SM, Engel AG. Slow-channel myasthenia due to novel mutation in M2 domain of AChR delta subunit. Annals of Clinical and Translational Neurology. PMID 31560172 DOI: 10.1002/Acn3.50902 |
0.443 |
|
2019 |
Sine SM, Strikwerda JR, Mazzaferro S. Structural basis for α-bungarotoxin insensitivity of neuronal nicotinic acetylcholine receptors. Neuropharmacology. 107660. PMID 31163179 DOI: 10.1016/J.Neuropharm.2019.05.037 |
0.486 |
|
2018 |
Mukhtasimova N, Sine SM. Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel. The Journal of General Physiology. PMID 29680816 DOI: 10.1085/Jgp.201711881 |
0.502 |
|
2018 |
Shen XM, Brengman JM, Shen S, Durmus H, Preethish-Kumar V, Yuceyar N, Vengalil S, Nalini A, Deymeer F, Sine SM, Engel AG. Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor ε-subunit. Jci Insight. 3. PMID 29367459 DOI: 10.1172/Jci.Insight.97826 |
0.482 |
|
2017 |
Bouzat C, Sine SM. Nicotinic Acetylcholine Receptors at the Single-Channel Level. British Journal of Pharmacology. PMID 28261794 DOI: 10.1111/Bph.13770 |
0.528 |
|
2016 |
Mazzaferro S, Bermudez I, Sine SM. α4β2 Nicotinic Acetylcholine Receptors: relationships between subunit stoichiometry and function at the single channel level. The Journal of Biological Chemistry. PMID 28031459 DOI: 10.1074/Jbc.M116.764183 |
0.497 |
|
2016 |
Mukhtasimova N, daCosta CJ, Sine SM. Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR. The Journal of General Physiology. 148: 43-63. PMID 27353445 DOI: 10.1085/Jgp.201611584 |
0.459 |
|
2015 |
Shen XM, Brengman J, Neubauer D, Sine SM, Engel AG. Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant AChR Cys-Loop Aspartates. The Journal of Biological Chemistry. PMID 26698174 DOI: 10.1074/Jbc.M115.683995 |
0.526 |
|
2015 |
daCosta CJ, Free CR, Sine SM. Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors. Nature Communications. 6: 8057. PMID 26282895 DOI: 10.1038/Ncomms9057 |
0.511 |
|
2015 |
Engel AG, Shen XM, Selcen D, Sine SM. Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment. The Lancet. Neurology. 14: 420-34. PMID 25792100 DOI: 10.1016/S1474-4422(14)70201-7 |
0.404 |
|
2013 |
Andersen N, Corradi J, Sine SM, Bouzat C. Stoichiometry for activation of neuronal α7 nicotinic receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 20819-24. PMID 24297903 DOI: 10.1073/Pnas.1315775110 |
0.591 |
|
2013 |
Sine SM, Huang S, Li SX, daCosta CJ, Chen L. Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors. The Biochemical Journal. 454: 311-21. PMID 23802200 DOI: 10.1042/Bj20130638 |
0.436 |
|
2013 |
Huang S, Li SX, Bren N, Cheng K, Gomoto R, Chen L, Sine SM. Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera. The Biochemical Journal. 454: 303-10. PMID 23800261 DOI: 10.1042/Bj20130636 |
0.433 |
|
2013 |
daCosta CJ, Sine SM. Stoichiometry for drug potentiation of a pentameric ion channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 6595-600. PMID 23576748 DOI: 10.1073/Pnas.1301909110 |
0.499 |
|
2013 |
Mukhtasimova N, Sine SM. Nicotinic receptor transduction zone: invariant arginine couples to multiple electron-rich residues. Biophysical Journal. 104: 355-67. PMID 23442857 DOI: 10.1016/J.Bpj.2012.12.013 |
0.56 |
|
2013 |
Engel AG, Shen XM, Selcen D, Sine S. New horizons for congenital myasthenic syndromes. Annals of the New York Academy of Sciences. 1275: 54-62. PMID 23278578 DOI: 10.1111/J.1749-6632.2012.06803.X |
0.347 |
|
2012 |
Sine SM. End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiological Reviews. 92: 1189-234. PMID 22811427 DOI: 10.1152/Physrev.00015.2011 |
0.415 |
|
2012 |
Shen XM, Brengman JM, Sine SM, Engel AG. Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating. The Journal of Clinical Investigation. 122: 2613-21. PMID 22728938 DOI: 10.1172/Jci63415 |
0.467 |
|
2012 |
Shen XM, Brengman JM, Edvardson S, Sine SM, Engel AG. Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site. Neurology. 79: 449-54. PMID 22592360 DOI: 10.1212/WNL.0b013e31825b5bda |
0.394 |
|
2012 |
Wang HL, Cheng X, Sine SM. Intramembrane proton binding site linked to activation of bacterial pentameric ion channel. The Journal of Biological Chemistry. 287: 6482-9. PMID 22084238 DOI: 10.1074/Jbc.M111.305839 |
0.432 |
|
2012 |
Bouzat CB, Andersen ND, Corradi J, Sine SM. Contribution of Agonist Binding Sites and Coupling Regions to Activation and Desensitization of Homomeric Cys-Loop Receptors Biophysical Journal. 102: 418a. DOI: 10.1016/J.Bpj.2011.11.2286 |
0.585 |
|
2011 |
daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM. Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13870-9. PMID 21957249 DOI: 10.1523/Jneurosci.2652-11.2011 |
0.481 |
|
2011 |
Li SX, Huang S, Bren N, Noridomi K, Dellisanti CD, Sine SM, Chen L. Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist. Nature Neuroscience. 14: 1253-9. PMID 21909087 DOI: 10.1038/Nn.2908 |
0.463 |
|
2011 |
Andersen N, Corradi J, Bartos M, Sine SM, Bouzat C. Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 3662-9. PMID 21389221 DOI: 10.1523/Jneurosci.5940-10.2011 |
0.549 |
|
2011 |
Shen X, Brengman J, Sine S, Engel A. P5.21 Novel mutation in the AChR alpha subunit C-loop dictates fast-channel kinetics by hindering channel opening triggered by agonists binding Neuromuscular Disorders. 21: 730. DOI: 10.1016/J.Nmd.2011.06.1050 |
0.528 |
|
2011 |
daCosta CJ, Free CR, Sine SM. Potentiation of the Human α7 Acetylcholine Receptor: A Single-Channel Study Biophysical Journal. 100: 347a. DOI: 10.1016/J.Bpj.2010.12.2094 |
0.451 |
|
2011 |
Andersen N, Corradi J, Bartos M, Sine SM, Bouzat CB. Number of Extracellular-Transmembrane Interfaces Required for Activation of Homomeric Cys-Loop Receptors Biophysical Journal. 100: 277a. DOI: 10.1016/J.Bpj.2010.12.1720 |
0.598 |
|
2010 |
Sine SM, Wang HL, Hansen S, Taylor P. On the origin of ion selectivity in the Cys-loop receptor family. Journal of Molecular Neuroscience : Mn. 40: 70-6. PMID 19728176 DOI: 10.1007/S12031-009-9260-1 |
0.722 |
|
2010 |
Wang H, Sine SM. Molecular Dynamics Simulation Reveals a Possible Mechanism of Activation of the Prokaryotic Proton Activated Channel Glic Biophysical Journal. 98: 133a. DOI: 10.1016/J.Bpj.2009.12.720 |
0.412 |
|
2009 |
Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA. Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor. Biophysical Journal. 96: 4502-13. PMID 19486673 DOI: 10.1016/J.Bpj.2009.03.018 |
0.502 |
|
2009 |
Rayes D, De Rosa MJ, Sine SM, Bouzat C. Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6022-32. PMID 19420269 DOI: 10.1523/Jneurosci.0627-09.2009 |
0.608 |
|
2009 |
Wang HL, Toghraee R, Papke D, Cheng XL, McCammon JA, Ravaioli U, Sine SM. Single-channel current through nicotinic receptor produced by closure of binding site C-loop. Biophysical Journal. 96: 3582-90. PMID 19413963 DOI: 10.1016/J.Bpj.2009.02.020 |
0.506 |
|
2009 |
Mukhtasimova N, Lee WY, Wang HL, Sine SM. Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature. 459: 451-4. PMID 19339970 DOI: 10.1038/Nature07923 |
0.708 |
|
2009 |
Lee WY, Free CR, Sine SM. Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3189-99. PMID 19279256 DOI: 10.1523/Jneurosci.6185-08.2009 |
0.632 |
|
2009 |
Bouzat CB, Rayes D, De Rosa MJ, Sine SM. Electrical Fingerprinting Reveals Agonist Binding Sites Required for Activation of Homo-pentameric Cys-loop Receptors Biophysical Journal. 96: 167a. DOI: 10.1016/J.Bpj.2008.12.772 |
0.538 |
|
2009 |
Mukhtasimoova NF, Lee WY, Wang H, Sine SM. Detection and Trapping of Elusive Priming Intermediates Towards Open Nicotinic Receptor Channel Biophysical Journal. 96: 167a. DOI: 10.1016/J.Bpj.2008.12.770 |
0.57 |
|
2008 |
Hansen SB, Wang HL, Taylor P, Sine SM. An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance. The Journal of Biological Chemistry. 283: 36066-70. PMID 18940802 DOI: 10.1074/Jbc.C800194200 |
0.711 |
|
2008 |
Bouzat C, Bartos M, Corradi J, Sine SM. The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7808-19. PMID 18667613 DOI: 10.1523/Jneurosci.0448-08.2008 |
0.503 |
|
2008 |
Lee WY, Free CR, Sine SM. Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating. The Journal of General Physiology. 132: 265-78. PMID 18663134 DOI: 10.1085/Jgp.200810014 |
0.689 |
|
2008 |
Engel AG, Shen XM, Selcen D, Sine SM. Further observations in congenital myasthenic syndromes. Annals of the New York Academy of Sciences. 1132: 104-13. PMID 18567859 DOI: 10.1196/Annals.1405.039 |
0.353 |
|
2008 |
Sine SM, Gao F, Lee WY, Mukhtasimova N, Wang HL, Engel AG. Recent structural and mechanistic insights into endplate acetylcholine receptors. Annals of the New York Academy of Sciences. 1132: 53-60. PMID 18567853 DOI: 10.1196/Annals.1405.041 |
0.698 |
|
2008 |
Wu TY, Smith CM, Sine SM, Levandoski MM. Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Molecular Pharmacology. 74: 466-75. PMID 18458055 DOI: 10.1124/Mol.107.044388 |
0.541 |
|
2008 |
Shen XM, Fukuda T, Ohno K, Sine SM, Engel AG. Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating. The Journal of Clinical Investigation. 118: 1867-76. PMID 18398509 DOI: 10.1172/Jci34527 |
0.515 |
|
2008 |
Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM. Control of cation permeation through the nicotinic receptor channel. Plos Computational Biology. 4: e41. PMID 18282090 DOI: 10.1371/Journal.Pcbi.0040041 |
0.593 |
|
2007 |
Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA. Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor. Biophysical Journal. 93: 2622-34. PMID 17573436 DOI: 10.1529/Biophysj.107.109843 |
0.405 |
|
2007 |
Ivanov I, Cheng X, Sine SM, McCammon JA. Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family. Journal of the American Chemical Society. 129: 8217-24. PMID 17552523 DOI: 10.1021/Ja070778L |
0.516 |
|
2007 |
Mukhtasimova N, Sine SM. An intersubunit trigger of channel gating in the muscle nicotinic receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4110-9. PMID 17428989 DOI: 10.1523/Jneurosci.0025-07.2007 |
0.604 |
|
2006 |
Cheng X, Wang H, Grant B, Sine SM, McCammon JA. Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. Plos Computational Biology. 2: e134. PMID 17009865 DOI: 10.1371/Journal.Pcbi.0020134 |
0.577 |
|
2006 |
Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM. Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop. Molecular Pharmacology. 70: 1230-5. PMID 16847142 DOI: 10.1124/Mol.106.027185 |
0.696 |
|
2006 |
Shen XM, Deymeer F, Sine SM, Engel AG. Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown. Annals of Neurology. 60: 128-36. PMID 16685696 DOI: 10.1002/Ana.20861 |
0.499 |
|
2006 |
Sine SM, Engel AG. Recent advances in Cys-loop receptor structure and function. Nature. 440: 448-55. PMID 16554804 DOI: 10.1038/Nature04708 |
0.498 |
|
2005 |
Lee WY, Sine SM. Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature. 438: 243-7. PMID 16281039 DOI: 10.1038/Nature04156 |
0.738 |
|
2005 |
Rayes D, Spitzmaul G, Sine SM, Bouzat C. Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors. Molecular Pharmacology. 68: 1475-83. PMID 16118362 DOI: 10.1124/Mol.105.015438 |
0.553 |
|
2005 |
Mukhtasimova N, Free C, Sine SM. Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor. The Journal of General Physiology. 126: 23-39. PMID 15955875 DOI: 10.1085/Jgp.200509283 |
0.63 |
|
2005 |
Engel AG, Sine SM. Current understanding of congenital myasthenic syndromes. Current Opinion in Pharmacology. 5: 308-21. PMID 15907919 DOI: 10.1016/J.Coph.2004.12.007 |
0.394 |
|
2005 |
Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain. Biophysical Journal. 88: 2564-76. PMID 15665135 DOI: 10.1529/Biophysj.104.053934 |
0.665 |
|
2005 |
Shen XM, Ohno K, Sine SM, Engel AG. Subunit-specific contribution to agonist binding and channel gating revealed by inherited mutation in muscle acetylcholine receptor M3-M4 linker. Brain : a Journal of Neurology. 128: 345-55. PMID 15615813 DOI: 10.1093/Brain/Awh364 |
0.53 |
|
2005 |
Gao F, Bren N, Burghardt TP, Hansen S, Henchman RH, Taylor P, McCammon JA, Sine SM. Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence. The Journal of Biological Chemistry. 280: 8443-51. PMID 15591050 DOI: 10.1074/Jbc.M412389200 |
0.725 |
|
2005 |
Pennington RA, Gao F, Sine SM, Prince RJ. Structural basis for epibatidine selectivity at desensitized nicotinic receptors. Molecular Pharmacology. 67: 123-31. PMID 15496507 DOI: 10.1124/Mol.104.003665 |
0.748 |
|
2004 |
Ellison M, Gao F, Wang HL, Sine SM, McIntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry. 43: 16019-26. PMID 15609996 DOI: 10.1021/Bi048918G |
0.479 |
|
2004 |
Lee WY, Sine SM. Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding. The Journal of General Physiology. 124: 555-67. PMID 15504901 DOI: 10.1085/Jgp.200409077 |
0.735 |
|
2004 |
Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, Sine SM. Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature. 430: 896-900. PMID 15318223 DOI: 10.1038/Nature02753 |
0.743 |
|
2004 |
Sine SM, Wang HL, Gao F. Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor. Current Medicinal Chemistry. 11: 559-67. PMID 15032604 DOI: 10.2174/0929867043455855 |
0.532 |
|
2004 |
Sine SM, Engel AG, Wang HL, Ohno K. Molecular insights into acetylcholine receptor structure and function revealed by mutations causing congenital myasthenic syndromes Advances in Molecular and Cell Biology. 32: 95-119. DOI: 10.1016/S1569-2558(03)32005-3 |
0.356 |
|
2003 |
Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: A diverse array of molecular targets. Journal of Neurocytology. 32: 1017-37. PMID 15034283 DOI: 10.1023/B:Neur.0000020639.22895.28 |
0.371 |
|
2003 |
Engel AG, Ohno K, Shen XM, Sine SM. Congenital myasthenic syndromes: multiple molecular targets at the neuromuscular junction. Annals of the New York Academy of Sciences. 998: 138-60. PMID 14592871 DOI: 10.1196/Annals.1254.016 |
0.403 |
|
2003 |
Sine SM, Wang HL, Ohno K, Shen XM, Lee WY, Engel AG. Mechanistic diversity underlying fast channel congenital myasthenic syndromes. Annals of the New York Academy of Sciences. 998: 128-37. PMID 14592870 DOI: 10.1196/Annals.1254.015 |
0.65 |
|
2003 |
Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation. Biophysical Journal. 85: 3007-18. PMID 14581202 DOI: 10.1016/S0006-3495(03)74720-1 |
0.671 |
|
2003 |
Wang HL, Gao F, Bren N, Sine SM. Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain. The Journal of Biological Chemistry. 278: 32284-91. PMID 12799358 DOI: 10.1074/Jbc.M304366200 |
0.541 |
|
2003 |
Engel AG, Ohno K, Sine SM. Sleuthing molecular targets for neurological diseases at the neuromuscular junction. Nature Reviews. Neuroscience. 4: 339-52. PMID 12728262 DOI: 10.1038/Nrn1101 |
0.342 |
|
2003 |
Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM. Curariform antagonists bind in different orientations to acetylcholine-binding protein. The Journal of Biological Chemistry. 278: 23020-6. PMID 12682067 DOI: 10.1074/Jbc.M301151200 |
0.801 |
|
2003 |
Shen XM, Ohno K, Tsujino A, Brengman JM, Gingold M, Sine SM, Engel AG. Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating. The Journal of Clinical Investigation. 111: 497-505. PMID 12588888 DOI: 10.1172/Jci16997 |
0.616 |
|
2003 |
Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: progress over the past decade. Muscle & Nerve. 27: 4-25. PMID 12508290 DOI: 10.1002/Mus.10269 |
0.409 |
|
2002 |
Sine SM. The nicotinic receptor ligand binding domain. Journal of Neurobiology. 53: 431-46. PMID 12436411 DOI: 10.1002/Neu.10139 |
0.6 |
|
2002 |
Engel AG, Ohno K, Sine SM. The spectrum of congenital myasthenic syndromes. Molecular Neurobiology. 26: 347-67. PMID 12428764 DOI: 10.1385/Mn:26:2-3:347 |
0.436 |
|
2002 |
Sine SM, Shen XM, Wang HL, Ohno K, Lee WY, Tsujino A, Brengmann J, Bren N, Vajsar J, Engel AG. Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. The Journal of General Physiology. 120: 483-96. PMID 12356851 DOI: 10.1085/Jgp.20028568 |
0.756 |
|
2002 |
Prince RJ, Pennington RA, Sine SM. Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors. The Journal of General Physiology. 120: 369-93. PMID 12198092 DOI: 10.1085/Jgp.20028583 |
0.727 |
|
2002 |
Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P. Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry. 41: 7895-906. PMID 12069578 DOI: 10.1021/Bi025732D |
0.67 |
|
2002 |
Sine SM, Wang HL, Bren N. Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain. The Journal of Biological Chemistry. 277: 29210-23. PMID 12011092 DOI: 10.1074/Jbc.M203396200 |
0.517 |
|
2002 |
Bouzat C, Gumilar F, del Carmen Esandi M, Sine SM. Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor. Biophysical Journal. 82: 1920-9. PMID 11916850 DOI: 10.1016/S0006-3495(02)75541-0 |
0.526 |
|
2002 |
Ibañez-Tallon I, Miwa JM, Wang HL, Adams NC, Crabtree GW, Sine SM, Heintz N. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron. 33: 893-903. PMID 11906696 DOI: 10.1016/S0896-6273(02)00632-3 |
0.44 |
|
2002 |
Molles BE, Rezai P, Kline EF, McArdle JJ, Sine SM, Taylor P. Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 277: 5433-40. PMID 11724791 DOI: 10.1074/Jbc.M109232200 |
0.614 |
|
2000 |
Malany S, Osaka H, Sine SM, Taylor P. Orientation of alpha-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor. Biochemistry. 39: 15388-98. PMID 11112524 DOI: 10.1021/Bi001825O |
0.587 |
|
2000 |
Wang HL, Ohno K, Milone M, Brengman JM, Evoli A, Batocchi AP, Middleton LT, Christodoulou K, Engel AG, Sine SM. Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. The Journal of General Physiology. 116: 449-62. PMID 10962020 DOI: 10.1085/Jgp.116.3.449 |
0.51 |
|
2000 |
Grosman C, Salamone FN, Sine SM, Auerbach A. The extracellular linker of muscle acetylcholine receptor channels is a gating control element. The Journal of General Physiology. 116: 327-40. PMID 10962011 DOI: 10.1085/Jgp.116.3.327 |
0.549 |
|
2000 |
Bouzat C, Barrantes F, Sine S. Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics. The Journal of General Physiology. 115: 663-72. PMID 10779322 DOI: 10.1085/Jgp.115.5.663 |
0.524 |
|
2000 |
Bren N, Sine SM. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. The Journal of Biological Chemistry. 275: 12692-700. PMID 10777563 DOI: 10.1074/Jbc.275.17.12692 |
0.497 |
|
2000 |
Osaka H, Malany S, Molles BE, Sine SM, Taylor P. Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 275: 5478-84. PMID 10681526 DOI: 10.1074/Jbc.275.8.5478 |
0.626 |
|
2000 |
Quiram PA, McIntosh JM, Sine SM. Pairwise interactions between neuronal alpha(7) acetylcholine receptors and alpha-conotoxin PnIB. The Journal of Biological Chemistry. 275: 4889-96. PMID 10671525 DOI: 10.1074/jbc.275.7.4889 |
0.452 |
|
1999 |
Quiram PA, Ohno K, Milone M, Patterson MC, Pruitt NJ, Brengman JM, Sine SM, Engel AG. Mutation causing congenital myasthenia reveals acetylcholine receptor beta/delta subunit interaction essential for assembly. The Journal of Clinical Investigation. 104: 1403-10. PMID 10562302 DOI: 10.1172/Jci8179 |
0.423 |
|
1999 |
Prince RJ, Sine SM. Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models. The Journal of Biological Chemistry. 274: 19623-9. PMID 10391899 DOI: 10.1074/Jbc.274.28.19623 |
0.746 |
|
1999 |
Quiram PA, Jones JJ, Sine SM. Pairwise interactions between neuronal alpha7 acetylcholine receptors and alpha-conotoxin ImI. The Journal of Biological Chemistry. 274: 19517-24. PMID 10391883 DOI: 10.1074/Jbc.274.28.19517 |
0.523 |
|
1999 |
Wang HL, Milone M, Ohno K, Shen XM, Tsujino A, Batocchi AP, Tonali P, Brengman J, Engel AG, Sine SM. Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating. Nature Neuroscience. 2: 226-33. PMID 10195214 DOI: 10.1038/6326 |
0.546 |
|
1999 |
Osaka H, Malany S, Kanter JR, Sine SM, Taylor P. Subunit interface selectivity of the alpha-neurotoxins for the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 9581-6. PMID 10092644 DOI: 10.1074/Jbc.274.14.9581 |
0.683 |
|
1999 |
Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: recent advances. Archives of Neurology. 56: 163-7. PMID 10025421 DOI: 10.1001/Archneur.56.2.163 |
0.447 |
|
1999 |
Wang H, Milone M, Ohno K, Shen X, Tsujino A, Batocchi AP, Tonali P, Brengman J, Engel AG, Sine SM. Erratum: Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating Nature Neuroscience. 2: 485-485. DOI: 10.1038/8161 |
0.358 |
|
1998 |
Engel AG, Ohno K, Sine SM. Congenital myasthenic syndromes: experiments of nature. Journal of Physiology, Paris. 92: 113-7. PMID 9782453 DOI: 10.1016/S0928-4257(98)80147-2 |
0.383 |
|
1998 |
Sine SM, Bren N, Quiram PA. Molecular dissection of subunit interfaces in the nicotinic acetylcholine receptor. Journal of Physiology, Paris. 92: 101-5. PMID 9782451 DOI: 10.1016/S0928-4257(98)80145-9 |
0.55 |
|
1998 |
Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I. Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure. Journal of Physiology, Paris. 92: 79-83. PMID 9782448 DOI: 10.1016/S0928-4257(98)80142-3 |
0.606 |
|
1998 |
Prince RJ, Sine SM. Epibatidine activates muscle acetylcholine receptors with unique site selectivity. Biophysical Journal. 75: 1817-27. PMID 9746523 DOI: 10.1016/S0006-3495(98)77623-4 |
0.769 |
|
1998 |
Quiram PA, Sine SM. Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. The Journal of Biological Chemistry. 273: 11007-11. PMID 9556581 DOI: 10.1074/Jbc.273.18.11007 |
0.517 |
|
1998 |
Quiram PA, Sine SM. Identification of residues in the neuronal alpha7 acetylcholine receptor that confer selectivity for conotoxin ImI. The Journal of Biological Chemistry. 273: 11001-6. PMID 9556580 DOI: 10.1074/Jbc.273.18.11001 |
0.451 |
|
1998 |
Sugiyama N, Marchot P, Kawanishi C, Osaka H, Molles B, Sine SM, Taylor P. Residues at the subunit interfaces of the nicotinic acetylcholine receptor that contribute to alpha-conotoxin M1 binding. Molecular Pharmacology. 53: 787-94. PMID 9547372 DOI: 10.1124/Mol.53.4.787 |
0.604 |
|
1998 |
Milone M, Wang HL, Ohno K, Prince R, Fukudome T, Shen XM, Brengman JM, Griggs RC, Sine SM, Engel AG. Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit. Neuron. 20: 575-88. PMID 9539130 DOI: 10.1016/S0896-6273(00)80996-4 |
0.684 |
|
1998 |
Prince RJ, Sine SM. Epibatidine binds with unique site and state selectivity to muscle nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 273: 7843-9. PMID 9525877 DOI: 10.1074/Jbc.273.14.7843 |
0.749 |
|
1998 |
Engel AG, Ohno K, Wang HL, Milone M, Sine SM. Molecular basis of congenital myasthenic syndromes: Mutations in the acetylcholine receptor Neuroscientist. 4: 185-194. DOI: 10.1177/107385849800400314 |
0.465 |
|
1998 |
Osaka H, Ackerman EJ, Kanter J, Tsigelny I, Sine SM, Taylor P. 80Binding orientation of the α-neurotoxins with the nicotinic acetylcholine receptor Journal of Physiology-Paris. 92: 476-477. DOI: 10.1016/S0928-4257(99)80092-8 |
0.619 |
|
1998 |
Molles B, Kline E, Sine S, McArdle J, Taylor P. 74Probing the structure of the ligand binding site on the muscle nicotinic receptor with Waglerin peptides Journal of Physiology-Paris. 92: 470-471. DOI: 10.1016/S0928-4257(99)80086-2 |
0.613 |
|
1997 |
Bren N, Sine SM. Identification of residues in the adult nicotinic acetylcholine receptor that confer selectivity for curariform antagonists. The Journal of Biological Chemistry. 272: 30793-8. PMID 9388220 DOI: 10.1074/Jbc.272.49.30793 |
0.551 |
|
1997 |
Sine SM. Identification of equivalent residues in the gamma, delta, and epsilon subunits of the nicotinic receptor that contribute to alpha-bungarotoxin binding. The Journal of Biological Chemistry. 272: 23521-7. PMID 9295287 DOI: 10.1074/Jbc.272.38.23521 |
0.549 |
|
1997 |
Wang HL, Auerbach A, Bren N, Ohno K, Engel AG, Sine SM. Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. The Journal of General Physiology. 109: 757-66. PMID 9222901 DOI: 10.1085/Jgp.109.6.757 |
0.595 |
|
1997 |
Milone M, Wang HL, Ohno K, Fukudome T, Pruitt JN, Bren N, Sine SM, Engel AG. Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5651-65. PMID 9221765 DOI: 10.1523/Jneurosci.17-15-05651.1997 |
0.571 |
|
1997 |
Tsigelny I, Sugiyama N, Sine SM, Taylor P. A model of the nicotinic receptor extracellular domain based on sequence identity and residue location. Biophysical Journal. 73: 52-66. PMID 9199771 DOI: 10.1016/S0006-3495(97)78047-0 |
0.681 |
|
1997 |
Ohno K, Quiram PA, Milone M, Wang HL, Harper MC, Pruitt JN, Brengman JM, Pao L, Fischbeck KH, Crawford TO, Sine SM, Engel AG. Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations. Human Molecular Genetics. 6: 753-66. PMID 9158150 DOI: 10.1093/Hmg/6.5.753 |
0.426 |
|
1997 |
Engel AG, Ohno K, Milone M, Sine SM. Congenital myasthenic syndromes caused by mutations in acetylcholine receptor genes Neurology. 48: S28-S35. DOI: 10.1212/Wnl.48.Suppl_5.28S |
0.505 |
|
1997 |
Milone M, Wang HL, Ohno K, Fukudome T, Pruitt J, Bren N, Sine SM, Engel AG. Slow-channel myasthenie syndrome caused by enhanced activation and agonist binding affinity due to mutation in the M2 domain of the ACHR α subunit Italian Journal of Neurological Sciences. 18: 24. |
0.426 |
|
1996 |
Engel AG, Ohno K, Bouzat C, Sine SM, Griggs RC. End-plate acetylcholine receptor deficiency due to nonsense mutations in the epsilon subunit. Annals of Neurology. 40: 810-7. PMID 8957026 DOI: 10.1002/Ana.410400521 |
0.477 |
|
1996 |
Fu DX, Sine SM. Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 271: 31479-84. PMID 8940161 DOI: 10.1074/Jbc.271.49.31479 |
0.65 |
|
1996 |
Akk G, Sine S, Auerbach A. Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. The Journal of Physiology. 496: 185-96. PMID 8910207 DOI: 10.1113/Jphysiol.1996.Sp021676 |
0.415 |
|
1996 |
Engel AG, Ohno K, Milone M, Wang HL, Nakano S, Bouzat C, Pruitt JN, Hutchinson DO, Brengman JM, Bren N, Sieb JP, Sine SM. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Human Molecular Genetics. 5: 1217-27. PMID 8872460 DOI: 10.1093/Hmg/5.9.1217 |
0.499 |
|
1996 |
Prince RJ, Sine SM. Molecular dissection of subunit interfaces in the acetylcholine receptor. Identification of residues that determine agonist selectivity. The Journal of Biological Chemistry. 271: 25770-7. PMID 8824205 DOI: 10.1074/Jbc.271.42.25770 |
0.772 |
|
1996 |
Ohno K, Wang HL, Milone M, Bren N, Brengman JM, Nakano S, Quiram P, Pruitt JN, Sine SM, Engel AG. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit. Neuron. 17: 157-70. PMID 8755487 DOI: 10.1016/S0896-6273(00)80289-5 |
0.517 |
|
1995 |
Chen J, Zhang Y, Akk G, Sine S, Auerbach A. Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophysical Journal. 69: 849-59. PMID 8519985 DOI: 10.1016/S0006-3495(95)79959-3 |
0.544 |
|
1995 |
Sine SM, Ohno K, Bouzat C, Auerbach A, Milone M, Pruitt JN, Engel AG. Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron. 15: 229-39. PMID 7619526 DOI: 10.1016/0896-6273(95)90080-2 |
0.563 |
|
1995 |
Sine SM, Kreienkamp HJ, Bren N, Maeda R, Taylor P. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity. Neuron. 15: 205-11. PMID 7619523 DOI: 10.1016/0896-6273(95)90077-2 |
0.617 |
|
1995 |
Ohno K, Hutchinson DO, Milone M, Brengman JM, Bouzat C, Sine SM, Engel AG. Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit. Proceedings of the National Academy of Sciences of the United States of America. 92: 758-62. PMID 7531341 DOI: 10.1073/Pnas.92.3.758 |
0.531 |
|
1994 |
Sine SM, Quiram P, Papanikolaou F, Kreienkamp HJ, Taylor P. Conserved tyrosines in the α subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists Journal of Biological Chemistry. 269: 8808-8816. PMID 8132615 |
0.654 |
|
1994 |
Bouzat C, Bren N, Sine SM. Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors. Neuron. 13: 1395-402. PMID 7993630 DOI: 10.1016/0896-6273(94)90424-3 |
0.546 |
|
1994 |
Fu DX, Sine SM. Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions. The Journal of Biological Chemistry. 269: 26152-7. PMID 7929328 |
0.651 |
|
1994 |
Kreienkamp HJ, Sine SM, Maeda RK, Taylor P. Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 269: 8108-14. PMID 7907588 |
0.585 |
|
1993 |
Sine SM. Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of residues that determine curare selectivity Proceedings of the National Academy of Sciences of the United States of America. 90: 9436-9440. PMID 8415719 DOI: 10.1073/Pnas.90.20.9436 |
0.595 |
|
1991 |
Sine SM, Claudio T. Stable expression of the mouse nicotinic acetylcholine receptor in mouse fibroblasts comparison of receptors in native and transfected cells Journal of Biological Chemistry. 266: 13679-13689. PMID 1713208 |
0.425 |
|
1991 |
Sine SM, Claudio T. γ- and δ-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor Journal of Biological Chemistry. 266: 19369-19377. PMID 1680865 |
0.486 |
|
1991 |
Sine S, Claudio T. Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor. Journal of Biological Chemistry. 266: 19369-19377. DOI: 10.1016/s0021-9258(18)55007-9 |
0.449 |
|
1990 |
Sine SM, Claudio T, Sigworth FJ. Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. The Journal of General Physiology. 96: 395-437. PMID 1698917 DOI: 10.1085/Jgp.96.2.395 |
0.439 |
|
1988 |
Sine SM. Functional properties of human skeletal muscle acetylcholine receptors expressed by the TE671 cell line Journal of Biological Chemistry. 263: 18052-18062. PMID 2461364 |
0.495 |
|
1988 |
Claudio T, Paulson HL, Hartman D, Sine S, Sigworth FJ. Chapter 11 Establishing a Stable Expression System for Studies of Acetylcholine Receptors Current Topics in Membranes and Transport. 33: 219-247. DOI: 10.1016/S0070-2161(08)60901-6 |
0.308 |
|
1988 |
Sine SM, Steinbach JH. Chapter 7 Function of Mammalian Nicotinic Acetylcholine Receptors: Agonist Concentration Dependence of Single Channel Current Kinetics Current Topics in Membranes and Transport. 33: 133-145. DOI: 10.1016/S0070-2161(08)60897-7 |
0.446 |
|
1987 |
Claudio T, Green WN, Hartman DS, Hayden D, Paulson HL, Sigworth FJ, Sine SM, Swedlund A. Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts. Science (New York, N.Y.). 238: 1688-94. PMID 3686008 DOI: 10.1126/Science.3686008 |
0.38 |
|
1987 |
Sine SM, Steinbach JH. Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist Journal of Physiology. 325-359. PMID 2443668 DOI: 10.1113/Jphysiol.1987.Sp016496 |
0.479 |
|
1987 |
Steinbach JH, Sine SM. Function of nicotinic acetylcholine receptors Society of General Physiologists Series. 41: 19-42. PMID 2436310 |
0.395 |
|
1986 |
Sine SM, Steinbach JH. Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by low concentrations of agonist The Journal of Physiology. 373: 129-162. PMID 2427693 DOI: 10.1113/jphysiol.1986.sp016039 |
0.396 |
|
1986 |
Sine SM, Steinbach JH. Acetylcholine receptor activation by a site‐selective ligand: nature of brief open and closed states in BC3H‐1 cells The Journal of Physiology. 370: 357-379. PMID 2420977 DOI: 10.1113/Jphysiol.1986.Sp015939 |
0.568 |
|
1984 |
Sine SM, Steinbach JH. Agonists block currents through acetylcholine receptor channels Biophysical Journal. 46: 277-284. PMID 6478036 DOI: 10.1016/S0006-3495(84)84022-9 |
0.436 |
|
1984 |
Sine SM, Steinbach JH. Activation of a nicotinic acetylcholine receptor Biophysical Journal. 45: 175-185. PMID 6324901 DOI: 10.1016/S0006-3495(84)84146-6 |
0.496 |
|
1982 |
Taylor P, Sine SM. Ligand occupation and the functional states of the nicotinic-cholinergic receptor Trends in Pharmacological Sciences. 3: 197-200. DOI: 10.1016/0165-6147(82)91091-4 |
0.664 |
|
1980 |
Sine SM, Taylor P. The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra α-toxin Journal of Biological Chemistry. 255: 10144-10156. PMID 7430118 |
0.469 |
|
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