| Year |
Citation |
Score |
| 2024 |
Gong Q, Sharma M, Kuan EL, Glass MC, Chander A, Singh M, Graybuck LT, Thomson ZJ, LaFrance CM, Zaim SR, Peng T, Okada LY, Genge PC, Henderson KE, Dornisch EM, ... ... Wherry EJ, et al. Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults. Biorxiv : the Preprint Server For Biology. PMID 39314416 DOI: 10.1101/2024.09.10.612119 |
0.317 |
|
| 2024 |
Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, ... Wherry EJ, et al. LAG-3 and PD-1 synergize on CD8 T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity. Cell. 187: 4355-4372.e22. PMID 39121848 DOI: 10.1016/j.cell.2024.07.016 |
0.468 |
|
| 2024 |
Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Mathew D, Chen Q, Khan O, Wu JE, Alcalde V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, ... ... Wherry EJ, et al. LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity. Cell. 187: 4336-4354.e19. PMID 39121847 DOI: 10.1016/j.cell.2024.07.018 |
0.568 |
|
| 2024 |
Mathew D, Marmarelis ME, Foley C, Bauml JM, Ye D, Ghinnagow R, Ngiow SF, Klapholz M, Jun S, Zhang Z, Zorc R, Davis CW, Diehn M, Giles JR, Huang AC, ... ... Wherry EJ, et al. Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients. Science (New York, N.Y.). 384: eadf1329. PMID 38900877 DOI: 10.1126/science.adf1329 |
0.443 |
|
| 2024 |
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, ... ... Wherry EJ, et al. Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nature Immunology. PMID 38267693 DOI: 10.1038/s41590-024-01757-5 |
0.46 |
|
| 2024 |
Maymí VI, Zhu H, Jager M, Johnson S, Getchell R, Casey JW, Grenier JK, Wherry EJ, Smith NL, Grimson A, Rudd BD. Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 38231127 DOI: 10.4049/jimmunol.2300396 |
0.551 |
|
| 2024 |
Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, ... ... Wherry EJ, et al. Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial. Nature Cancer. PMID 38216766 DOI: 10.1038/s43018-023-00709-6 |
0.39 |
|
| 2023 |
Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, ... ... Wherry EJ, et al. Stat5 opposes the transcription factor Tox and rewires exhausted CD8 T cells toward durable effector-like states during chronic antigen exposure. Immunity. 56: 2699-2718.e11. PMID 38091951 DOI: 10.1016/j.immuni.2023.11.005 |
0.489 |
|
| 2023 |
Cai C, Gao Y, Adamo S, Rivera-Ballesteros O, Hansson L, Österborg A, Bergman P, Sandberg JK, Ljunggren HG, Björkström NK, Strålin K, Llewellyn-Lacey S, Price DA, Qin C, Grifoni A, ... ... Wherry EJ, et al. SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19. Science Immunology. 8: eadh0687. PMID 38064569 DOI: 10.1126/sciimmunol.adh0687 |
0.541 |
|
| 2023 |
Hsu J, Donahue RN, Katragadda M, Lowry J, Huang W, Srinivasan K, Guntas G, Tang J, Servattalab R, Moisan J, Tsai YT, Stoop A, Palakurthi S, Chopra R, Liu K, ... Wherry EJ, et al. A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity. Science Translational Medicine. 15: eadi0258. PMID 38019931 DOI: 10.1126/scitranslmed.adi0258 |
0.532 |
|
| 2023 |
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, ... ... Wherry EJ, et al. Trimodal single-cell profiling reveals a novel pediatric CD8αα T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nature Immunology. PMID 37845489 DOI: 10.1038/s41590-023-01641-8 |
0.451 |
|
| 2023 |
Giles JR, Globig AM, Kaech SM, Wherry EJ. CD8 T cells in the cancer-immunity cycle. Immunity. 56: 2231-2253. PMID 37820583 DOI: 10.1016/j.immuni.2023.09.005 |
0.723 |
|
| 2023 |
Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, ... ... Wherry EJ, et al. Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nature Immunology. PMID 37735592 DOI: 10.1038/s41590-023-01613-y |
0.467 |
|
| 2023 |
Wu JE, Manne S, Ngiow SF, Baxter AE, Huang H, Freilich E, Clark ML, Lee JH, Chen Z, Khan O, Staupe RP, Huang YJ, Shi J, Giles JR, Wherry EJ. In vitro modeling of CD8 T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40. Science Immunology. 8: eade3369. PMID 37595022 DOI: 10.1126/sciimmunol.ade3369 |
0.472 |
|
| 2023 |
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state, and its deletion improves checkpoint blockade. Cell Reports. 42: 112905. PMID 37527035 DOI: 10.1016/j.celrep.2023.112905 |
0.599 |
|
| 2023 |
Baxter AE, Huang H, Giles JR, Chen Z, Wu JE, Drury S, Dalton K, Park SL, Torres L, Simone BW, Klapholz M, Ngiow SF, Freilich E, Manne S, Alcalde V, ... ... Wherry EJ, et al. The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8 T cells. Immunity. 56: 1320-1340.e10. PMID 37315535 DOI: 10.1016/j.immuni.2023.05.008 |
0.519 |
|
| 2023 |
Wu JE, Manne S, Ngiow SF, Baxter AE, Huang H, Freilich E, Clark ML, Lee JH, Chen Z, Khan O, Staupe RP, Huang YJ, Shi J, Giles JR, Wherry EJ. Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40. Biorxiv : the Preprint Server For Biology. PMID 37131713 DOI: 10.1101/2023.04.17.537229 |
0.484 |
|
| 2023 |
Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, ... Wherry EJ, et al. Human T follicular helper clones seed the germinal center-resident regulatory pool. Science Immunology. 8: eade8162. PMID 37027481 DOI: 10.1126/sciimmunol.ade8162 |
0.547 |
|
| 2023 |
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state and its deletion improves checkpoint blockade. Biorxiv : the Preprint Server For Biology. PMID 36824931 DOI: 10.1101/2023.02.16.528833 |
0.574 |
|
| 2023 |
Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, ... ... Wherry EJ, et al. Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies. Biorxiv : the Preprint Server For Biology. PMID 36798171 DOI: 10.1101/2023.02.05.527215 |
0.461 |
|
| 2023 |
Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Nature Cancer. PMID 36646856 DOI: 10.1038/s43018-022-00490-y |
0.429 |
|
| 2022 |
Nicolas A, Sannier G, Dubé M, Nayrac M, Tauzin A, Painter MM, Goel RR, Laporte M, Gendron-Lepage G, Medjahed H, Williams JC, Brassard N, Niessl J, Gokool L, Morrisseau C, ... ... Wherry EJ, et al. Extended SARS-CoV-2 mRNA vaccine prime-boost intervals enhances B cell immunity with limited impact on T cells. Iscience. 105904. PMID 36594081 DOI: 10.1016/j.isci.2022.105904 |
0.473 |
|
| 2022 |
Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, ... ... Wherry EJ, et al. Author Correction: Decade-long leukaemia remissions with persistence of CD4 CAR T cells. Nature. PMID 36477542 DOI: 10.1038/s41586-022-05376-8 |
0.514 |
|
| 2022 |
Daniel B, Yost KE, Hsiung S, Sandor K, Xia Y, Qi Y, Hiam-Galvez KJ, Black M, J Raposo C, Shi Q, Meier SL, Belk JA, Giles JR, Wherry EJ, Chang HY, et al. Divergent clonal differentiation trajectories of T cell exhaustion. Nature Immunology. PMID 36289450 DOI: 10.1038/s41590-022-01337-5 |
0.545 |
|
| 2022 |
Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, ... ... Wherry EJ, et al. Shared and distinct biological circuits in effector, memory and exhausted CD8 T cells revealed by temporal single-cell transcriptomics and epigenetics. Nature Immunology. PMID 36271148 DOI: 10.1038/s41590-022-01338-4 |
0.622 |
|
| 2022 |
Wherry EJ, Barouch DH. T cell immunity to COVID-19 vaccines. Science (New York, N.Y.). 377: 821-822. PMID 35981045 DOI: 10.1126/science.add2897 |
0.345 |
|
| 2022 |
Herati RS, Knorr DA, Vella LA, Silva LV, Chilukuri L, Apostolidis SA, Huang AC, Muselman A, Manne S, Kuthuru O, Staupe RP, Adamski SA, Kannan S, Kurupati RK, Ertl HCJ, ... ... Wherry EJ, et al. PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology. 23: 1183-1192. PMID 35902637 DOI: 10.1038/s41590-022-01274-3 |
0.325 |
|
| 2022 |
Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, ... ... Wherry EJ, et al. Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial. Nature Medicine. PMID 35662283 DOI: 10.1038/s41591-022-01829-9 |
0.314 |
|
| 2022 |
Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA. Autoreactive CD8 T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nature Immunology. 23: 868-877. PMID 35618829 DOI: 10.1038/s41590-022-01210-5 |
0.582 |
|
| 2022 |
Alanio C, Binder ZA, Chang RB, Nasrallah MP, Delman D, Li JH, Tang OY, Zhang LY, Zhang JV, Wherry EJ, O'Rourke DM, Beatty GL. Immunological features in de novo and recurrent glioblastoma associate with survival outcomes. Cancer Immunology Research. PMID 35507919 DOI: 10.1158/2326-6066.CIR-21-1050 |
0.369 |
|
| 2022 |
Stelekati E, Cai Z, Manne S, Chen Z, Beltra JC, Buchness LA, Leng X, Ristin S, Nzingha K, Ekshyyan V, Niavi C, Abdel-Hakeem MS, Ali MA, Drury S, Lau CW, ... ... Wherry EJ, et al. MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection. Proceedings of the National Academy of Sciences of the United States of America. 119: e2106083119. PMID 35446623 DOI: 10.1073/pnas.2106083119 |
0.488 |
|
| 2022 |
Vardhana S, Baldo L, Morice WG, Wherry EJ. Understanding T-cell responses to COVID-19 is essential for informing public health strategies. Science Immunology. eabo1303. PMID 35324269 DOI: 10.1126/sciimmunol.abo1303 |
0.381 |
|
| 2022 |
Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, ... ... Wherry EJ, et al. Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Immunity. 55: 557-574.e7. PMID 35263570 DOI: 10.1016/j.immuni.2022.02.004 |
0.54 |
|
| 2022 |
Lederer K, Bettini E, Parvathaneni K, Painter MM, Agarwal D, Lundgreen KA, Weirick M, Muralidharan K, Castaño D, Goel RR, Xu X, Drapeau EM, Gouma S, Ort JT, Awofolaju M, ... ... Wherry EJ, et al. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Cell. PMID 35202565 DOI: 10.1016/j.cell.2022.01.027 |
0.364 |
|
| 2022 |
Tsao HW, Kaminski J, Kurachi M, Barnitz RA, DiIorio MA, LaFleur MW, Ise W, Kurosaki T, Wherry EJ, Haining WN, Yosef N. Batf-mediated epigenetic control of effector CD8 T cell differentiation. Science Immunology. 7: eabi4919. PMID 35179948 DOI: 10.1126/sciimmunol.abi4919 |
0.458 |
|
| 2022 |
Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, ... ... Wherry EJ, et al. Decade-long leukaemia remissions with persistence of CD4 CAR T cells. Nature. PMID 35110735 DOI: 10.1038/s41586-021-04390-6 |
0.563 |
|
| 2021 |
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of Experimental Medicine. 219. PMID 34882194 DOI: 10.1084/jem.20201599 |
0.527 |
|
| 2021 |
Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, ... ... Wherry EJ, et al. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science (New York, N.Y.). eabm0829. PMID 34648302 DOI: 10.1126/science.abm0829 |
0.311 |
|
| 2021 |
Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nature Immunology. PMID 34588688 DOI: 10.1038/s41590-021-01057-2 |
0.456 |
|
| 2021 |
Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, ... ... Wherry EJ, et al. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Medrxiv : the Preprint Server For Health Sciences. PMID 34580676 DOI: 10.1101/2021.09.16.21263686 |
0.362 |
|
| 2021 |
Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Brunazzi EA, Ngiow SF, Harusato A, Sharpe AH, Wherry EJ, Taniuchi I, Workman CJ, Vignali DAA. A Cre-driven allele-conditioning line to interrogate CD4 conventional T cells. Immunity. PMID 34551314 DOI: 10.1016/j.immuni.2021.08.029 |
0.549 |
|
| 2021 |
Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, ... ... Wherry EJ, et al. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nature Medicine. PMID 34522051 DOI: 10.1038/s41591-021-01507-2 |
0.457 |
|
| 2021 |
Chong EA, Alanio C, Svoboda J, Nasta SD, Landsburg DJ, Lacey SF, Ruella M, Bhattacharyya S, Wherry EJ, Schuster SJ. Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy. Blood. PMID 34496014 DOI: 10.1182/blood.2021012634 |
0.534 |
|
| 2021 |
Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, ... ... Wherry EJ, et al. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern. Biorxiv : the Preprint Server For Biology. PMID 34462751 DOI: 10.1101/2021.08.23.457229 |
0.324 |
|
| 2021 |
Painter MM, Mathew D, Goel RR, Apostolidis SA, Pattekar A, Kuthuru O, Baxter AE, Herati RS, Oldridge DA, Gouma S, Hicks P, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, ... ... Wherry EJ, et al. Rapid induction of antigen-specific CD4 T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity. PMID 34453880 DOI: 10.1016/j.immuni.2021.08.001 |
0.473 |
|
| 2021 |
Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nature Immunology. 22: 1008-1019. PMID 34312545 DOI: 10.1038/s41590-021-00975-5 |
0.582 |
|
| 2021 |
Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA, Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, ... ... Wherry EJ, et al. CD8 T cells contribute to survival in patients with COVID-19 and hematologic cancer. Nature Medicine. PMID 34017137 DOI: 10.1038/s41591-021-01386-7 |
0.376 |
|
| 2021 |
McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, ... ... Wherry EJ, et al. Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell Reports. 35: 109120. PMID 33979613 DOI: 10.1016/j.celrep.2021.109120 |
0.527 |
|
| 2021 |
Muroyama Y, Wherry EJ. Memory T-Cell Heterogeneity and Terminology. Cold Spring Harbor Perspectives in Biology. 13. PMID 33782027 DOI: 10.1101/cshperspect.a037929 |
0.604 |
|
| 2021 |
Benallegue N, Kebir H, Kapoor R, Crockett A, Li C, Cheslow L, Abdel-Hakeem MS, Gesualdi J, Miller MC, Wherry EJ, Church ME, Blanco MA, Alvarez JI. The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. Brain : a Journal of Neurology. PMID 33723591 DOI: 10.1093/brain/awab083 |
0.497 |
|
| 2021 |
Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, et al. Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8 T cells. Nature Immunology. PMID 33658708 DOI: 10.1038/s41590-021-00906-4 |
0.425 |
|
| 2021 |
Vella LA, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, ... ... Wherry EJ, et al. Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Science Immunology. 6. PMID 33653907 DOI: 10.1126/sciimmunol.abf7570 |
0.303 |
|
| 2021 |
Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, ... ... Wherry EJ, et al. In vivo CD8 T cell CRISPR screening reveals control by Fli1 in infection and cancer. Cell. PMID 33636129 DOI: 10.1016/j.cell.2021.02.019 |
0.579 |
|
| 2021 |
Yao C, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D'Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, et al. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8 T cells. Nature Immunology. PMID 33574619 DOI: 10.1038/s41590-021-00868-7 |
0.524 |
|
| 2021 |
Huang A, Bange E, Han N, Wileyto EP, Kim J, Gouma S, Robinson J, Greenplate A, Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman A, Ittner C, ... ... Wherry E, et al. CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer. Research Square. PMID 33564756 DOI: 10.21203/rs.3.rs-162289/v1 |
0.413 |
|
| 2021 |
Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, ... ... Wherry EJ, et al. Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine. PMID 33547459 DOI: 10.1038/s41591-021-01248-2 |
0.45 |
|
| 2021 |
Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, ... ... Wherry EJ, et al. Inhibitory signaling sustains a distinct early memory CD8 T cell precursor that is resistant to DNA damage. Science Immunology. 6. PMID 33452106 DOI: 10.1126/sciimmunol.abe3702 |
0.838 |
|
| 2021 |
Pattekar A, Mayer LS, Lau CW, Liu C, Palko O, Bewtra M, Consortium HPAP, Lindesmith LC, Brewer-Jensen PD, Baric RS, Betts MR, Naji A, Wherry EJ, Tomov VT. Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues. Cellular and Molecular Gastroenterology and Hepatology. PMID 33444817 DOI: 10.1016/j.jcmgh.2020.12.012 |
0.477 |
|
| 2020 |
Buggert M, Vella LA, Nguyen S, Wu VH, Chen Z, Sekine T, Perez-Potti A, Maldini CR, Manne S, Darko S, Ransier A, Kuri-Cervantes L, Japp AS, Brody IB, Ivarsson MA, ... ... Wherry EJ, et al. The Identity of Human Tissue-Emigrant CD8 T Cells. Cell. PMID 33306960 DOI: 10.1016/j.cell.2020.11.019 |
0.519 |
|
| 2020 |
Vella L, Giles JR, Baxter AE, Oldridge DA, Diorio C, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, ... ... Wherry EJ, et al. Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 32995826 DOI: 10.1101/2020.09.25.20201863 |
0.303 |
|
| 2020 |
Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, ... ... Wherry EJ, et al. PPT1 Inhibition enhances the anti-tumor activity of anti-PD-1 antibody in melanoma. Jci Insight. PMID 32780726 DOI: 10.1172/Jci.Insight.133225 |
0.412 |
|
| 2020 |
Chen Z, Wherry EJ. T cell responses in patients with COVID-19. Nature Reviews Immunology. 20: 529-536. PMID 32728222 DOI: 10.1038/S41577-020-0402-6 |
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| 2020 |
Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, ... ... Wherry EJ, et al. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science (New York, N.Y.). PMID 32669297 DOI: 10.1126/Science.Abc8511 |
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Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman AR, Agyekum RS, Mathew D, Baxter AE, Vella LA, Kuthuru O, Apostolidis SA, Bershaw L, Dougherty J, Greenplate AR, ... ... Wherry EJ, et al. Comprehensive mapping of immune perturbations associated with severe COVID-19. Science Immunology. 5. PMID 32669287 DOI: 10.1126/Sciimmunol.Abd7114 |
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| 2020 |
Pauken KE, Godec J, Odorizzi PM, Brown KE, Yates KB, Ngiow SF, Burke KP, Maleri S, Grande SM, Francisco LM, Ali MA, Imam S, Freeman GJ, Haining WN, Wherry EJ, et al. The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection. Cell Reports. 31: 107827. PMID 32610128 DOI: 10.1016/J.Celrep.2020.107827 |
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| 2020 |
Jeong YH, Walsh MC, Yu J, Shen H, Wherry EJ, Choi Y. Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to . Journal of Immunology (Baltimore, Md. : 1950). PMID 32540996 DOI: 10.4049/Jimmunol.1901423 |
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| 2020 |
Kuri-Cervantes L, Pampena MB, Meng W, Rosenfeld AM, Ittner CAG, Weisman AR, Agyekum R, Mathew D, Baxter AE, Vella L, Kuthuru O, Apostolidis S, Bershaw L, Dougherty J, Greenplate AR, ... ... Wherry EJ, et al. Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 32511394 DOI: 10.1101/2020.05.18.101717 |
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| 2020 |
Mathew D, Giles JR, Baxter AE, Greenplate AR, Wu JE, Alanio C, Oldridge DA, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, ... ... Wherry EJ, et al. Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions. Biorxiv : the Preprint Server For Biology. PMID 32511371 DOI: 10.1101/2020.05.20.106401 |
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| 2020 |
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, ... ... Wherry EJ, et al. Developmental Relationships of Four Exhausted CD8 T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity. PMID 32396847 DOI: 10.1016/J.Immuni.2020.04.014 |
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| 2020 |
Johnson JL, Rosenthal RL, Knox JJ, Myles A, Naradikian MS, Madej J, Kostiv M, Rosenfeld AM, Meng W, Christensen SR, Hensley SE, Yewdell J, Canaday DH, Zhu J, McDermott AB, ... ... Wherry EJ, et al. The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans. Immunity. PMID 32353250 DOI: 10.1016/J.Immuni.2020.03.020 |
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| 2020 |
Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, et al. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. The Journal of Experimental Medicine. 217. PMID 32150623 DOI: 10.1084/Jem.20190888 |
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| 2020 |
Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ. Reinvigorating NIH Grant Peer Review. Immunity. 52: 1-3. PMID 31940266 DOI: 10.1016/J.Immuni.2019.12.016 |
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| 2020 |
O'Boyle KC, Ohtani T, Manne S, Bengsch B, Henrickson SE, Wherry EJ, Alanio C. Exploration of T-Cell Diversity Using Mass Cytometry. Methods in Molecular Biology (Clifton, N.J.). 2111: 1-20. PMID 31933194 DOI: 10.1007/978-1-0716-0266-9_1 |
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| 2020 |
Shah PD, Huang ACC, Xu X, Zhang PJ, Orlowski R, Matlawski T, Shea J, Cervini A, Amaravadi RK, Tchou JC, Schuchter LM, Wherry EJ, Linette GP, Mick R, Kulikovskaya I, et al. Phase I trial of autologous cMET-directed CAR-t cells administered intravenously in patients with melanoma & breast carcinoma. Journal of Clinical Oncology. 38: 10035-10035. DOI: 10.1200/Jco.2020.38.15_Suppl.10035 |
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| 2019 |
Chen Z, Ji Z, Ngiow SF, Manne S, Cai Z, Huang AC, Johnson J, Staupe RP, Bengsch B, Xu C, Yu S, Kurachi M, Herati RS, Vella LA, Baxter AE, ... ... Wherry EJ, et al. TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. Immunity. PMID 31606264 DOI: 10.1016/J.Immuni.2019.09.013 |
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| 2019 |
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, ... Wherry EJ, et al. Defining 'T cell exhaustion'. Nature Reviews. Immunology. PMID 31570879 DOI: 10.1038/S41577-019-0221-9 |
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| 2019 |
Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, ... ... Wherry EJ, et al. Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. The Journal of Allergy and Clinical Immunology. PMID 31445098 DOI: 10.1016/J.Jaci.2019.08.007 |
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| 2019 |
Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, Wherry EJ, Zhang NR, Ishwaran H, Hellmann MD, Wolchok JD, et al. Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade. Cell. 178: 933-948.e14. PMID 31398344 DOI: 10.1016/J.Cell.2019.07.019 |
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| 2019 |
Vella LA, Buggert M, Manne S, Herati RS, Sayin I, Kuri-Cervantes L, Bukh Brody I, O'Boyle KC, Kaprielian H, Giles JR, Nguyen S, Muselman A, Antel JP, Bar-Or A, Johnson ME, ... ... Wherry EJ, et al. T follicular helper cells in human efferent lymph retain lymphoid characteristics. The Journal of Clinical Investigation. 130. PMID 31264971 DOI: 10.1172/Jci125628 |
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| 2019 |
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, ... ... Wherry EJ, et al. Single-cell RNA-seq reveals TOX as a key regulator of CD8 T cell persistence in chronic infection. Nature Immunology. PMID 31209400 DOI: 10.1038/S41590-019-0403-4 |
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| 2019 |
Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP, ... ... Wherry EJ, et al. TOX transcriptionally and epigenetically programs CD8 T cell exhaustion. Nature. PMID 31207603 DOI: 10.1038/S41586-019-1325-X |
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Kotzin JJ, Iseka F, Wright J, Basavappa MG, Clark ML, Ali MA, Abdel-Hakeem MS, Robertson TF, Mowel WK, Joannas L, Neal VD, Spencer SP, Syrett CM, Anguera MC, Williams A, ... Wherry EJ, et al. The long noncoding RNA regulates CD8 T cells in response to viral infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31138702 DOI: 10.1073/Pnas.1819457116 |
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| 2019 |
Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, D'Andrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, ... ... Wherry EJ, et al. A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma. Nature Medicine. PMID 30804515 DOI: 10.1038/S41591-019-0357-Y |
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McLane LM, Abdel-Hakeem MS, Wherry EJ. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. Annual Review of Immunology. PMID 30676822 DOI: 10.1146/Annurev-Immunol-041015-055318 |
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Giles JR, Huang AC, Manne S, Henao-Meji J, Wherry EJ. Abstract B012: Characterizing tumor-induced exhaustion in melanoma patients treated with neoadjuvant pembrolizumab Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B012 |
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| 2019 |
Khan O, Giles JR, McDonald S, Wherry EJ. Abstract A197: The HMG transcription factor TOX induces a transcriptional and epigenetic program of CD8+ T-cell exhaustion in chronic infection and cancer Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A197 |
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Abdel-Hakeem MS, Beltra J, Chen Z, Johnson J, Manne S, Ali M, Wherry EJ. Abstract A166: Reprogramming of exhausted T-cells following cure of chronic viral infection Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A166 |
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Alanio C, Bengsch B, Gies JR, Henrickson S, Weng NP, Ritz-Romeo JA, O'Hara M, Melenhorst JJ, Lacey S, Young RM, June CH, Wherry EJ. Abstract A123: Skewed CD4 and CD8 T-cell differentiation in pancreatic cancer patients Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A123 |
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Zappasodi R, Budhu S, Hellmann MD, Postow MA, Senbabaoglu Y, Manne S, Gasmi B, Liu C, Zhong H, Li Y, Huang AC, Hirschhorn-Cymerman D, Panageas KS, Wherry EJ, Merghoub T, et al. Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer Cell. 34: 691. PMID 30300585 DOI: 10.1016/j.ccell.2018.09.007 |
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| 2018 |
Bajor DL, Mick R, Riese MJ, Huang AC, Sullivan B, Richman LP, Torigian DA, George SM, Stelekati E, Chen F, Melenhorst JJ, Lacey SF, Xu X, Wherry EJ, Gangadhar TC, et al. Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma. Oncoimmunology. 7: e1468956. PMID 30288340 DOI: 10.1080/2162402X.2018.1468956 |
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Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, ... ... Wherry EJ, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. PMID 30089911 DOI: 10.1038/S41586-018-0392-8 |
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Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin JH, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, ... ... Wherry EJ, et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity. PMID 29958801 DOI: 10.1016/J.Immuni.2018.06.006 |
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Zappasodi R, Budhu S, Hellmann MD, Postow MA, Senbabaoglu Y, Manne S, Gasmi B, Liu C, Zhong H, Li Y, Huang AC, Hirschhorn-Cymerman D, Panageas KS, Wherry EJ, Merghoub T, et al. Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer Cell. 33: 1017-1032.e7. PMID 29894689 DOI: 10.1016/J.Ccell.2018.05.009 |
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Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, ... ... Wherry EJ, et al. Identification and characterization of HIV-specific resident memory CD8 T cells in human lymphoid tissue. Science Immunology. 3. PMID 29858286 DOI: 10.1126/Sciimmunol.Aar4526 |
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| 2018 |
Taylor MD, Burn TN, Wherry EJ, Behrens EM. CD8 T Cell Memory Increases Immunopathology in the Perforin-Deficient Model of Hemophagocytic Lymphohistiocytosis Secondary to TNF-α. Immunohorizons. 2: 67-73. PMID 29795796 DOI: 10.4049/immunohorizons.1800003 |
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Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH. Spatial distribution and function of T follicular regulatory cells in human lymph nodes. The Journal of Experimental Medicine. PMID 29769249 DOI: 10.1084/Jem.20171940 |
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Stelekati E, Chen Z, Manne S, Kurachi M, Ali MA, Lewy K, Cai Z, Nzingha K, McLane LM, Hope JL, Fike AJ, Katsikis PD, Wherry EJ. Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155. Cell Reports. 23: 2142-2156. PMID 29768211 DOI: 10.1016/J.Celrep.2018.04.038 |
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| 2018 |
Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ. Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells. Immunity. 48: 1029-1045.e5. PMID 29768164 DOI: 10.1016/J.Immuni.2018.04.026 |
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Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, ... ... Wherry EJ, et al. Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine. PMID 29713085 DOI: 10.1038/S41591-018-0010-1 |
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Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg J, Eller MA, Streeck H, Jansson M, ... ... Wherry EJ, et al. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. Plos Pathogens. 14: e1006973. PMID 29652923 DOI: 10.1371/Journal.Ppat.1006973 |
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Johnson JL, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, Pear WS, Bhandoola A, Wherry EJ, Vahedi G. Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity. 48: 243-257.e10. PMID 29466756 DOI: 10.1016/J.Immuni.2018.01.012 |
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Henrickson SE, Manne S, Dolfi DV, Mansfield KD, Parkhouse K, Mistry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports. 22: 411-426. PMID 29320737 DOI: 10.1016/J.Celrep.2017.12.043 |
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Henrickson SE, Bengsch B, Manne S, O'Boyle KC, Herati RS, Vella LA, Hensley SE, Rabinowitz JR, Coffin S, Wherry EJ. Chronic Allergen Stimulation Yields T cell Dysfunction in Obese Asthmatics Journal of Allergy and Clinical Immunology. 141: AB285. DOI: 10.1016/J.Jaci.2017.12.907 |
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Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, et al. The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1. Frontiers in Immunology. 8: 1696. PMID 29358931 DOI: 10.3389/Fimmu.2017.01696 |
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Carty SA, Gohil M, Banks LB, Cotton RM, Johnson ME, Stelekati E, Wells AD, Wherry EJ, Koretzky GA, Jordan MS. The Loss of TET2 Promotes CD8(+) T Cell Memory Differentiation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29150566 DOI: 10.4049/Jimmunol.1700559 |
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Vella LA, Herati RS, Wherry EJ. CD4+ T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective. Trends in Molecular Medicine. 23: 1072-1087. PMID 29137933 DOI: 10.1016/J.Molmed.2017.10.001 |
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Tomov VT, Palko O, Lau CW, Pattekar A, Sun Y, Tacheva R, Bengsch B, Manne S, Cosma GL, Eisenlohr LC, Nice TJ, Virgin HW, Wherry EJ. Differentiation and Protective Capacity of Virus-Specific CD8(+) T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche. Immunity. PMID 29031786 DOI: 10.1016/J.Immuni.2017.09.017 |
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Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, ... ... Wherry EJ, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 47: 435-449.e8. PMID 28930659 DOI: 10.1016/J.Immuni.2017.08.012 |
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Chen Z, Stelekati E, Kurachi M, Yu S, Cai Z, Manne S, Khan O, Yang X, Wherry EJ. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Cell Reports. 20: 2584-2597. PMID 28903040 DOI: 10.1016/J.Celrep.2017.08.060 |
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Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ. Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function. Nature Protocols. 12: 1980-1998. PMID 28858287 DOI: 10.1038/Nprot.2017.083 |
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Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. Plos Pathogens. 13: e1006544. PMID 28827827 DOI: 10.1371/Journal.Ppat.1006544 |
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Herati RS, Muselman A, Vella L, Bengsch B, Parkhouse K, Del Alcazar D, Kotzin J, Doyle SA, Tebas P, Hensley SE, Su LF, Schmader KE, Wherry EJ. Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells. Science Immunology. 2. PMID 28620653 DOI: 10.1126/Sciimmunol.Aag2152 |
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Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, ... ... Wherry EJ, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. PMID 28397821 DOI: 10.1038/Nature22079 |
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Bengsch B, Ohtani T, Herati RS, Bovenschen N, Chang KM, Wherry EJ. Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. Journal of Immunological Methods. PMID 28322863 DOI: 10.1016/J.Jim.2017.03.009 |
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Fraietta JA, Lacey SF, Orlando E, Pruteanu J, Gohil M, Wang Y, Boesteanu A, OConnor R, Ambrose DE, Hwang W, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Parakandi H, ... ... Wherry EJ, et al. Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia Blood. 130: 3181-3181. DOI: 10.1182/Blood.V130.Suppl_1.3181.3181 |
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Wolchok JD, Wherry EJ. Webinar | Deciphering cancer: Modulating immunoregulatory pathways to treat tumors Science. 355: 210-210. DOI: 10.1126/Science.355.6321.210-B |
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Tomov V, Palko O, Lau CW, Bewtra M, Wherry EJ. Human Norovirus-Specific T Cell Responses Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)33394-2 |
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| 2016 |
Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, ... ... Wherry EJ, et al. Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell. 167: 1540-1554.e12. PMID 27912061 DOI: 10.1016/J.Cell.2016.11.022 |
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Barton BM, Xu R, Wherry EJ, Porrett PM. Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells. Journal of Leukocyte Biology. PMID 27810945 DOI: 10.1189/Jlb.1A0316-135R |
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Sen DR, Kaminski J, Barnitz RA, Kurachi M, Gerdemann U, Yates KB, Tsao HW, Godec J, LaFleur MW, Brown FD, Tonnerre P, Chung RT, Tully DC, Allen TM, Frahm N, ... ... Wherry EJ, et al. The epigenetic landscape of T cell exhaustion. Science (New York, N.Y.). PMID 27789799 DOI: 10.1126/science.aae0491 |
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Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen D, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, ... ... Wherry EJ, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science (New York, N.Y.). PMID 27789795 DOI: 10.1126/Science.Aaf2807 |
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Su LF, Del Alcazar D, Stelekati E, Wherry EJ, Davis MM. Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood. Proceedings of the National Academy of Sciences of the United States of America. PMID 27681619 DOI: 10.1073/Pnas.1611723113 |
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| 2016 |
Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, ... ... Wherry EJ, et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. PMID 27525555 DOI: 10.1038/Nature19346 |
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Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, Stelekati E, McLane LM, Paley MA, Delgoffe GM, Wherry EJ. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. PMID 27496729 DOI: 10.1016/J.Immuni.2016.07.008 |
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| 2016 |
Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ. Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 27430722 DOI: 10.4049/Jimmunol.1500368 |
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Naradikian MS, Myles A, Beiting DP, Roberts KJ, Dawson L, Herati RS, Bengsch B, Linderman SL, Stelekati E, Spolski R, Wherry EJ, Hunter C, Hensley SE, Leonard WJ, Cancro MP. Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 27430719 DOI: 10.4049/Jimmunol.1600522 |
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Nice TJ, Osborne LC, Tomov VT, Artis D, Wherry EJ, Virgin HW. Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity. Plos Pathogens. 12: e1005684. PMID 27327515 DOI: 10.1371/Journal.Ppat.1005684 |
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|
| 2016 |
Attanasio J, Wherry EJ. Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. Immunity. 44: 1052-68. PMID 27192569 DOI: 10.1016/J.Immuni.2016.04.022 |
0.369 |
|
| 2016 |
Minn AJ, Wherry EJ. Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling. Cell. 165: 272-5. PMID 27058661 DOI: 10.1016/J.Cell.2016.03.031 |
0.306 |
|
| 2016 |
Riou C, Strickland N, Soares AP, Corleis B, Kwon DS, Wherry EJ, Wilkinson RJ, Burgers WA. HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 26927799 DOI: 10.4049/Jimmunol.1502094 |
0.489 |
|
| 2016 |
Carty SA, Gohil M, Banks LB, Johnson ME, Stelekati E, Wells AD, Wherry EJ, Koretzky GA, Jordan MS. The Methylcytosine Dioxygenase TET2 Regulates CD8+ T Cell Memory Differentiation Blood. 128: 3692-3692. DOI: 10.1182/Blood.V128.22.3692.3692 |
0.681 |
|
| 2016 |
Victor CT, Rech A, Maity A, Rengan R, Pauken K, Stelekati E, Benci J, Xu B, Dada H, Odorizzi P, Herati R, Mansfield K, Patsch D, Amaravadi R, Schuchter L, ... ... Wherry EJ, et al. Abstract A056: Mechanisms of tumor response and resistance to radiation and dual checkpoint blockade in mice and patients Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A056 |
0.473 |
|
| 2016 |
Wherry EJ. Abstract IA06: Molecular basis of T cell exhaustion: Insights for immunotherapy Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-Ia06 |
0.648 |
|
| 2016 |
Pauken KE, Sammons MA, Odorizzi PM, Manne SK, Godec J, Khan O, Sen D, Kurachi M, Barnitz RA, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, ... Wherry EJ, et al. Abstract B104: Impact of PD-1 blockade on epigenetic and transcriptional reprogramming of exhausted T cells Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B104 |
0.627 |
|
| 2015 |
Pauken KE, Wherry EJ. SnapShot: T Cell Exhaustion. Cell. 163: 1038-1038.e1. PMID 26544946 DOI: 10.1016/J.Cell.2015.10.054 |
0.637 |
|
| 2015 |
Rood JE, Rao S, Paessler M, Kreiger PA, Chu N, Stelekati E, Wherry EJ, Behrens EM. ST2 contributes to T cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice. Blood. PMID 26518437 DOI: 10.1182/Blood-2015-07-659813 |
0.602 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. Plos Pathogens. 11: e1005177. PMID 26485519 DOI: 10.1371/Journal.Ppat.1005177 |
0.684 |
|
| 2015 |
Lee JE, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses. Plos One. 10: e0137776. PMID 26367121 DOI: 10.1371/Journal.Pone.0137776 |
0.682 |
|
| 2015 |
Zehn D, Wherry EJ. Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model. Advances in Experimental Medicine and Biology. 850: 137-52. PMID 26324351 DOI: 10.1007/978-3-319-15774-0_10 |
0.532 |
|
| 2015 |
Crosby EJ, Clark M, Novais FO, Wherry EJ, Scott P. Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbate Disease in Mice Coinfected with Leishmania major. Journal of Immunology (Baltimore, Md. : 1950). PMID 26290604 DOI: 10.4049/Jimmunol.1500855 |
0.545 |
|
| 2015 |
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nature Reviews. Immunology. 15: 486-99. PMID 26205583 DOI: 10.1038/Nri3862 |
0.626 |
|
| 2015 |
Beiting DP, Hidano S, Baggs JE, Geskes JM, Fang Q, Wherry EJ, Hunter CA, Roos DS, Cherry S. The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii. Plos Biology. 13: e1002200. PMID 26196739 DOI: 10.1371/Journal.Pbio.1002200 |
0.536 |
|
| 2015 |
Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. The Journal of Experimental Medicine. 212: 1125-37. PMID 26034050 DOI: 10.1084/Jem.20142237 |
0.802 |
|
| 2015 |
Pombo C, Wherry EJ, Gostick E, Price DA, Betts MR. Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers. The Journal of Infectious Diseases. PMID 25883386 DOI: 10.1093/Infdis/Jiv226 |
0.575 |
|
| 2015 |
Schlie K, Westerback A, DeVorkin L, Hughson LR, Brandon JM, MacPherson S, Gadawski I, Townsend KN, Poon VI, Elrick MA, Côté HCF, Abraham N, Wherry EJ, Mizushima N, Lum JJ. Survival of effector CD8+ T cells during influenza infection is dependent on autophagy Journal of Immunology. 194: 4277-4286. PMID 25833396 DOI: 10.4049/Jimmunol.1402571 |
0.679 |
|
| 2015 |
Pauken KE, Wherry EJ. Overcoming T cell exhaustion in infection and cancer. Trends in Immunology. 36: 265-76. PMID 25797516 DOI: 10.1016/J.It.2015.02.008 |
0.456 |
|
| 2015 |
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, ... ... Wherry EJ, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 520: 373-7. PMID 25754329 DOI: 10.1038/Nature14292 |
0.529 |
|
| 2015 |
Bengsch B, Wherry EJ. The importance of cooperation: partnerless NFAT induces T cell exhaustion. Immunity. 42: 203-5. PMID 25692694 DOI: 10.1016/J.Immuni.2015.01.023 |
0.521 |
|
| 2015 |
Winograd R, Byrne KT, Evans RA, Odorizzi PM, Meyer AR, Bajor DL, Clendenin C, Stanger BZ, Furth EE, Wherry EJ, Vonderheide RH. Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma. Cancer Immunology Research. 3: 399-411. PMID 25678581 DOI: 10.1158/2326-6066.Cir-14-0215 |
0.461 |
|
| 2015 |
Kahan SM, Wherry EJ, Zajac AJ. T cell exhaustion during persistent viral infections. Virology. 479: 180-93. PMID 25620767 DOI: 10.1016/J.Virol.2014.12.033 |
0.636 |
|
| 2015 |
Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, et al. Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science (New York, N.Y.). 347: 278-82. PMID 25593185 DOI: 10.1126/Science.Aaa2148 |
0.718 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. Terminally exhausted CD8 + T cells marked by high levels of CD39 are most impaired in their effector function. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G007 |
0.553 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 is highly up-regulated by exhausted CD8 + T cells in a mouse model of chronic infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G005 |
0.591 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 expression correlates with PD-1 expression and viral load in chronic viral infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G003 |
0.424 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 expressed by CD8 + T cells in HCV infection is enzymatically active. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G002 |
0.539 |
|
| 2015 |
Carty SA, Gohil M, Stelekati E, Banks LB, Wherry EJ, Koretzky GA, Jordan MS. TET2 Regulates CD8+ T Cell Responses to Acute and Chronic Viral Infection Blood. 126: 2227-2227. DOI: 10.1182/Blood.V126.23.2227.2227 |
0.705 |
|
| 2015 |
Wherry EJ. Abstract IA01: Molecular basis of T cell exhaustion: Insights for immunotherapy Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-Ia01 |
0.666 |
|
| 2015 |
Rech AJ, Twyman C, Maity A, Rengan R, Pauken KE, Stelekati E, Xu B, Dada H, Odorizzi PM, Herati RD, Mansfield KD, Patsch D, Amaravadi R, Schuchter L, Ishwaran H, ... ... Wherry EJ, et al. Abstract A52: Radiation and dual PD-L1 and CTLA4 checkpoint blockade non-redundantly improves tumor resistance, response, and immunity Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A52 |
0.43 |
|
| 2015 |
Bajor DL, Mick R, Riese MJ, Lee RP, Xu X, Torigian DA, Stelekati E, Sweeney M, Sullivan BJ, Schuchter LM, Amaravadi R, Wherry EJ, Vonderheide RH. Abstract A38: Phase I study of combination immunotherapy with agonistic CD40 monoclonal antibody (mAb) CP-870,893 (αCD40) and anti-CTLA-4 antibody tremelimumab (treme) in patients with metastatic melanoma Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-A38 |
0.431 |
|
| 2015 |
Bajor DL, Mick R, Riese MJ, Richman LP, Xu X, Torigian DA, Stelekati E, Sweeney M, Sullivan B, Schuchter LM, Amaravadi R, Wherry EJ, Vonderheide RH. Abstract CT137: Combination of agonistic CD40 monoclonal antibody CP-870,893 and anti-CTLA-4 antibody tremelimumab in patients with metastatic melanoma Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ct137 |
0.45 |
|
| 2015 |
Rech AJ, Victor CT, Maity A, Rengan R, Pauken KE, Stelekati E, Benci J, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, ... ... Wherry EJ, et al. Abstract 2858: Radiation and dual immune checkpoint blockade overcome tumor resistance and distinctly improve immunity Cancer Research. 75: 2858-2858. DOI: 10.1158/1538-7445.Am2015-2858 |
0.434 |
|
| 2014 |
Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, et al. Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity. 41: 1001-12. PMID 25526311 DOI: 10.1016/J.Immuni.2014.12.011 |
0.585 |
|
| 2014 |
Pauken KE, Wherry EJ. TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit. Cancer Cell. 26: 785-7. PMID 25490444 DOI: 10.1016/J.Ccell.2014.11.016 |
0.551 |
|
| 2014 |
Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nature Immunology. 15: 1104-15. PMID 25396352 DOI: 10.1038/Ni.3031 |
0.597 |
|
| 2014 |
Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ. Circulating CXCR5+PD-1+response predicts influenza vaccine antibody responses in young adults but not elderly adults Journal of Immunology. 193: 3528-3537. PMID 25172499 DOI: 10.4049/Jimmunol.1302503 |
0.339 |
|
| 2014 |
Osborne LC, Monticelli LA, Nice TJ, Sutherland TE, Siracusa MC, Hepworth MR, Tomov VT, Kobuley D, Tran SV, Bittinger K, Bailey AG, Laughlin AL, Boucher JL, Wherry EJ, Bushman FD, et al. Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science (New York, N.Y.). 345: 578-82. PMID 25082704 DOI: 10.1126/Science.1256942 |
0.329 |
|
| 2014 |
Chaix J, Nish SA, Lin WH, Rothman NJ, Ding L, Wherry EJ, Reiner SL. Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. Journal of Immunology (Baltimore, Md. : 1950). 193: 1013-6. PMID 24973450 DOI: 10.4049/Jimmunol.1400488 |
0.601 |
|
| 2014 |
Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Puré E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM. Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4262-73. PMID 24919573 DOI: 10.1158/1078-0432.Ccr-13-2627 |
0.469 |
|
| 2014 |
Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, ... Wherry EJ, et al. Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity. 40: 801-13. PMID 24837104 DOI: 10.1016/J.Immuni.2014.04.010 |
0.85 |
|
| 2014 |
Barnett LG, Simkins HMA, Barnett BE, Korn LL, Johnson AL, Wherry EJ, Wu GF, Laufer TM. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation Journal of Immunology. 192: 3607-3617. PMID 24646739 DOI: 10.4049/Jimmunol.1301284 |
0.654 |
|
| 2014 |
Schadler KL, Crosby EJ, Zhou AY, Bhang DH, Braunstein L, Baek KH, Crawford D, Crawford A, Angelosanto J, Wherry EJ, Ryeom S. Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. Cancer Research. 74: 2171-81. PMID 24590059 DOI: 10.1158/0008-5472.Can-13-0094 |
0.534 |
|
| 2014 |
Crosby EJ, Goldschmidt MH, Wherry EJ, Scott P. Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. Plos Pathogens. 10: e1003970. PMID 24586170 DOI: 10.1371/Journal.Ppat.1003970 |
0.659 |
|
| 2014 |
Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, Yates K, Godec J, Klatt MG, Regev A, Wherry EJ, Haining WN. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nature Immunology. 15: 373-83. PMID 24584090 DOI: 10.1038/Ni.2834 |
0.605 |
|
| 2014 |
Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. Journal of Immunology (Baltimore, Md. : 1950). 192: 3190-9. PMID 24567531 DOI: 10.4049/Jimmunol.1302985 |
0.659 |
|
| 2014 |
Crawford A, Angelosanto JM, Kao C, Doering TA, Odorizzi PM, Barnett BE, Wherry EJ. Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. Immunity. 40: 289-302. PMID 24530057 DOI: 10.1016/J.Immuni.2014.01.005 |
0.677 |
|
| 2014 |
Beiting DP, Peixoto L, Akopyants NS, Beverley SM, Wherry EJ, Christian DA, Hunter CA, Brodsky IE, Roos DS. Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. Plos One. 9: e88398. PMID 24505488 DOI: 10.1371/Journal.Pone.0088398 |
0.531 |
|
| 2014 |
Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, et al. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 146: 550-61. PMID 24148617 DOI: 10.1053/J.Gastro.2013.10.022 |
0.54 |
|
| 2014 |
Turner DL, Bickham KL, Thome JJ, Kim CY, D'Ovidio F, Wherry EJ, Farber DL. Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunology. 7: 501-10. PMID 24064670 DOI: 10.1038/Mi.2013.67 |
0.554 |
|
| 2014 |
Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM. AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 28-41. PMID 23778424 DOI: 10.1038/Mt.2013.134 |
0.563 |
|
| 2013 |
Parzych EM, DiMenna LJ, Latimer BP, Small JC, Kannan S, Manson B, Lasaro MO, Wherry EJ, Ertl HC. Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice. Biomed Research International. 2013: 876314. PMID 24187666 DOI: 10.1155/2013/876314 |
0.354 |
|
| 2013 |
Dolfi DV, Mansfield KD, Kurupati RK, Kannan S, Doyle SA, Ertl HC, Schmader KE, Wherry EJ. Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. Plos One. 8: e77164. PMID 24155927 DOI: 10.1371/Journal.Pone.0077164 |
0.527 |
|
| 2013 |
Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. The Journal of Experimental Medicine. 210: 1823-37. PMID 23960191 DOI: 10.1084/Jem.20122332 |
0.391 |
|
| 2013 |
Buchlis G, Odorizzi P, Soto PC, Pearce OM, Hui DJ, Jordan MS, Varki A, Wherry EJ, High KA. Enhanced T cell function in a mouse model of human glycosylation. Journal of Immunology (Baltimore, Md. : 1950). 191: 228-37. PMID 23709682 DOI: 10.4049/Jimmunol.1202905 |
0.572 |
|
| 2013 |
Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 498: 113-7. PMID 23698371 DOI: 10.1038/Nature12240 |
0.577 |
|
| 2013 |
Bedoya F, Cheng GS, Leibow A, Zakhary N, Weissler K, Garcia V, Aitken M, Kropf E, Garlick DS, Wherry EJ, Erikson J, Caton AJ. Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 6115-25. PMID 23667113 DOI: 10.4049/Jimmunol.1203302 |
0.601 |
|
| 2013 |
Gracias DT, Stelekati E, Hope JL, Boesteanu AC, Doering TA, Norton J, Mueller YM, Fraietta JA, Wherry EJ, Turner M, Katsikis PD. The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nature Immunology. 14: 593-602. PMID 23603793 DOI: 10.1038/Ni.2576 |
0.532 |
|
| 2013 |
Tomov VT, Osborne LC, Dolfi DV, Sonnenberg GF, Monticelli LA, Mansfield K, Virgin HW, Artis D, Wherry EJ. Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. Journal of Virology. 87: 7015-31. PMID 23596300 DOI: 10.1128/Jvi.03389-12 |
0.641 |
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| 2013 |
Odorizzi PM, Wherry EJ. Immunology. An interferon paradox. Science (New York, N.Y.). 340: 155-6. PMID 23580520 DOI: 10.1126/Science.1237568 |
0.328 |
|
| 2013 |
Laidlaw BJ, Decman V, Ali MA, Abt MC, Wolf AI, Monticelli LA, Mozdzanowska K, Angelosanto JM, Artis D, Erikson J, Wherry EJ. Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity. Plos Pathogens. 9: e1003207. PMID 23516357 DOI: 10.1371/Journal.Ppat.1003207 |
0.46 |
|
| 2013 |
Jackson SR, Berrien-Elliott MM, Meyer JM, Wherry EJ, Teague RM. CD8+ T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor. Immunological Investigations. 42: 204-20. PMID 23461613 DOI: 10.3109/08820139.2012.751397 |
0.683 |
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| 2013 |
McLane LM, Banerjee PP, Cosma GL, Makedonas G, Wherry EJ, Orange JS, Betts MR. Differential localization of T-bet and Eomes in CD8 T cell memory populations Journal of Immunology. 190: 3207-3215. PMID 23455505 DOI: 10.4049/Jimmunol.1201556 |
0.65 |
|
| 2013 |
Dolfi DV, Mansfield KD, Polley AM, Doyle SA, Freeman GJ, Pircher H, Schmader KE, Wherry EJ. Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. Journal of Leukocyte Biology. 93: 825-36. PMID 23440501 DOI: 10.1189/Jlb.0912438 |
0.61 |
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| 2013 |
Paley MA, Gordon SM, Bikoff EK, Robertson EJ, Wherry EJ, Reiner SL. Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes. Journal of Leukocyte Biology. 93: 307-15. PMID 23192430 DOI: 10.1189/jlb.0812400 |
0.789 |
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| 2013 |
Wherry EJ. Molecular Basis of T-Cell Exhaustion Blood. 122. DOI: 10.1182/Blood.V122.21.Sci-38.Sci-38 |
0.662 |
|
| 2013 |
Barnitz RA, Kurachi M, Lemieux ME, Yosef N, DiIorio MA, Yates KB, Godec J, Odorizzi P, Regev A, Wherry EJ, Haining WN. The Transcription Factor BATF Controls CD8+ T Cell Effector Differentiation Blood. 122: 189-189. DOI: 10.1182/Blood.V122.21.189.189 |
0.647 |
|
| 2012 |
Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science (New York, N.Y.). 338: 1220-5. PMID 23197535 DOI: 10.1126/Science.1229620 |
0.835 |
|
| 2012 |
Doering TA, Crawford A, Angelosanto JM, Paley MA, Ziegler CG, Wherry EJ. Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity. 37: 1130-44. PMID 23159438 DOI: 10.1016/J.Immuni.2012.08.021 |
0.808 |
|
| 2012 |
Stelekati E, Wherry EJ. Chronic bystander infections and immunity to unrelated antigens. Cell Host & Microbe. 12: 458-69. PMID 23084915 DOI: 10.1016/J.Chom.2012.10.001 |
0.401 |
|
| 2012 |
Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 37: 158-70. PMID 22705104 DOI: 10.1016/J.Immuni.2012.04.011 |
0.704 |
|
| 2012 |
Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host & Microbe. 11: 643-53. PMID 22704624 DOI: 10.1016/J.Chom.2012.04.016 |
0.609 |
|
| 2012 |
Angelosanto JM, Blackburn SD, Crawford A, Wherry EJ. Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection. Journal of Virology. 86: 8161-70. PMID 22623779 DOI: 10.1128/JVI.00889-12 |
0.641 |
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| 2012 |
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Odorizzi PM, Wherry EJ. Inhibitory receptors on lymphocytes: insights from infections. Journal of Immunology (Baltimore, Md. : 1950). 188: 2957-65. PMID 22442493 DOI: 10.4049/Jimmunol.1100038 |
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Harris JE, Harris TH, Weninger W, Wherry EJ, Hunter CA, Turka LA. A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⺠T-cell accumulation in the skin. The Journal of Investigative Dermatology. 132: 1869-76. PMID 22297636 DOI: 10.1038/Jid.2011.463 |
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Decman V, Laidlaw BJ, Doering TA, Leng J, Ertl HC, Goldstein DR, Wherry EJ. Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors. Journal of Immunology (Baltimore, Md. : 1950). 188: 1933-41. PMID 22246631 DOI: 10.4049/Jimmunol.1101098 |
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Wang T, Huang C, Lopez-Coral A, Slentz-Kesler KA, Xiao M, Wherry EJ, Kaufman RE. K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. Journal of Leukocyte Biology. 91: 449-59. PMID 22184754 DOI: 10.1189/Jlb.1011498 |
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Iyer SS, Chatraw JH, Tan WG, Wherry EJ, Becker TC, Ahmed R, Kapasi ZF. Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 77-84. PMID 22116826 DOI: 10.4049/Jimmunol.1004027 |
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Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. Journal of Immunology (Baltimore, Md. : 1950). 187: 5510-4. PMID 22058417 DOI: 10.4049/Jimmunol.1102243 |
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Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, ... ... Wherry EJ, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature Immunology. 12: 1045-54. PMID 21946417 DOI: 10.1031/Ni.2131 |
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Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 477: 229-33. PMID 21841801 DOI: 10.1038/Nature10329 |
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Crawford A, Angelosanto JM, Nadwodny KL, Blackburn SD, Wherry EJ. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. Plos Pathogens. 7: e1002098. PMID 21814510 DOI: 10.1371/Journal.Ppat.1002098 |
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Wherry EJ. T cell exhaustion. Nature Immunology. 12: 492-9. PMID 21739672 DOI: 10.1038/Ni.2035 |
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Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nature Immunology. 12: 663-71. PMID 21623380 DOI: 10.1038/Ni.2046 |
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Zediak VP, Wherry EJ, Berger SL. The contribution of epigenetic memory to immunologic memory. Current Opinion in Genetics & Development. 21: 154-9. PMID 21330128 DOI: 10.1016/J.Gde.2011.01.016 |
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Zediak VP, Johnnidis JB, Wherry EJ, Berger SL. Cutting edge: persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status. Journal of Immunology (Baltimore, Md. : 1950). 186: 2705-9. PMID 21278341 DOI: 10.4049/Jimmunol.1003741 |
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Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 117: 3123-30. PMID 21233312 DOI: 10.1182/Blood-2010-11-318485 |
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Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. Journal of Immunology (Baltimore, Md. : 1950). 185: 4988-92. PMID 20935204 DOI: 10.4049/Jimmunol.1002042 |
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Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, ... ... Wherry EJ, et al. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nature Medicine. 16: 1147-51. PMID 20890291 DOI: 10.1038/Nm.2232 |
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Wiehagen KR, Corbo E, Schmidt M, Shin H, Wherry EJ, Maltzman JS. Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells Blood. 116: 5560-5570. PMID 20884806 DOI: 10.1182/Blood-2010-06-292458 |
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Smith-Garvin JE, Burns JC, Gohil M, Zou T, Kim JS, Maltzman JS, Wherry EJ, Koretzky GA, Jordan MS. T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood. 116: 5548-59. PMID 20847203 DOI: 10.1182/Blood-2010-06-292748 |
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Paley MA, Wherry EJ. TCF-1 flips the switch on Eomes. Immunity. 33: 145-7. PMID 20732636 DOI: 10.1016/J.Immuni.2010.08.008 |
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Samimi S, Benoit B, Evans K, Wherry EJ, Showe L, Wysocka M, Rook AH. Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppression. Archives of Dermatology. 146: 1382-8. PMID 20713771 DOI: 10.1001/Archdermatol.2010.200 |
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Angelosanto JM, Wherry EJ. Transcription factor regulation of CD8+ T-cell memory and exhaustion. Immunological Reviews. 236: 167-75. PMID 20636816 DOI: 10.1111/J.1600-065X.2010.00927.X |
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Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Current Opinion in Immunology. 22: 397-401. PMID 20427170 DOI: 10.1016/J.Coi.2010.03.007 |
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Decman V, Laidlaw BJ, Dimenna LJ, Abdulla S, Mozdzanowska K, Erikson J, Ertl HC, Wherry EJ. Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection. Journal of Immunology (Baltimore, Md. : 1950). 184: 5151-9. PMID 20368274 DOI: 10.4049/Jimmunol.0902063 |
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Makedonas G, Hutnick N, Haney D, Amick AC, Gardner J, Cosma G, Hersperger AR, Dolfi D, Wherry EJ, Ferrari G, Betts MR. Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. Plos Pathogens. 6: e1000798. PMID 20221423 DOI: 10.1371/Journal.Ppat.1000798 |
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Haining WN, Wherry EJ. Integrating genomic signatures for immunologic discovery. Immunity. 32: 152-61. PMID 20189480 DOI: 10.1016/J.Immuni.2010.02.001 |
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Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS, Fraser KA, Webby RJ, Brinkmann V, Butcher EC, Newell KA, et al. Dynamic T cell migration program provides resident memory within intestinal epithelium. The Journal of Experimental Medicine. 207: 553-64. PMID 20156972 DOI: 10.1084/Jem.20090858 |
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Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ. Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion. Journal of Virology. 84: 2078-89. PMID 19955307 DOI: 10.1128/Jvi.01579-09 |
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Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 31: 309-20. PMID 19664943 DOI: 10.1016/J.Immuni.2009.06.019 |
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Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 138: 30-50. PMID 19596234 DOI: 10.1016/J.Cell.2009.06.036 |
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Zhang Z, Jin B, Zhang JY, Xu B, Wang H, Shi M, Wherry EJ, Lau GK, Wang FS. Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients. Journal of Hepatology. 50: 1163-73. PMID 19395117 DOI: 10.1016/J.Jhep.2009.01.026 |
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Crawford A, Wherry EJ. The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses. Current Opinion in Immunology. 21: 179-86. PMID 19264470 DOI: 10.1016/J.Coi.2009.01.010 |
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Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. Plos Pathogens. 5: e1000313. PMID 19247441 DOI: 10.1371/Journal.Ppat.1000313 |
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Wilson EH, Harris TH, Mrass P, John B, Tait ED, Wu GF, Pepper M, Wherry EJ, Dzierzinski F, Roos D, Haydon PG, Laufer TM, Weninger W, Hunter CA. Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. Immunity. 30: 300-11. PMID 19167248 DOI: 10.1016/J.Immuni.2008.12.013 |
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Wolf AI, Buehler D, Hensley SE, Cavanagh LL, Wherry EJ, Kastner P, Chan S, Weninger W. Plasmacytoid dendritic cells are dispensable during primary influenza virus infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 871-9. PMID 19124730 DOI: 10.4049/Jimmunol.182.2.871 |
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Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nature Immunology. 10: 29-37. PMID 19043418 DOI: 10.1038/Ni.1679 |
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Banerjee A, Gordon SM, Intlekofer AM, Wherry EJ, Reiner SL. Defective Central Memory CD8+ T Cell Differentiation in the Absence of Eomesodermin. Blood. 114: 2662-2662. DOI: 10.1182/Blood.V114.22.2662.2662 |
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Blackburn SD, Shin H, Freeman GJ, Wherry EJ. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proceedings of the National Academy of Sciences of the United States of America. 105: 15016-21. PMID 18809920 DOI: 10.1073/Pnas.0801497105 |
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Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1859-68. PMID 18641323 DOI: 10.4049/Jimmunol.181.3.1859 |
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Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (New York, N.Y.). 321: 408-11. PMID 18635804 DOI: 10.1126/Science.1159806 |
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Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM. Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology. 134: 1927-37, 1937.e1-2. PMID 18549878 DOI: 10.1053/J.Gastro.2008.02.033 |
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Zhang Z, Zhang JY, Wherry EJ, Jin B, Xu B, Zou ZS, Zhang SY, Li BS, Wang HF, Wu H, Lau GK, Fu YX, Wang FS. Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology. 134: 1938-49, 1949.e1-3. PMID 18455515 DOI: 10.1053/J.Gastro.2008.03.037 |
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Chatraw JH, Wherry EJ, Ahmed R, Kapasi ZF. Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors. The Journal of Nutrition. 138: 806-12. PMID 18356339 DOI: 10.1093/Jn/138.4.806 |
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Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. The Journal of Experimental Medicine. 205: 543-55. PMID 18332181 DOI: 10.1084/Jem.20071949 |
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Lasaro MO, Tatsis N, Hensley SE, Whitbeck JC, Lin SW, Rux JJ, Wherry EJ, Cohen GH, Eisenberg RJ, Ertl HC. Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses. Nature Medicine. 14: 205-12. PMID 18193057 DOI: 10.1038/Nm1704 |
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Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ. Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 179: 6704-14. PMID 17982060 DOI: 10.4049/Jimmunol.179.10.6704 |
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Masopust D, Vezys V, Wherry EJ, Ahmed R. A brief history of CD8 T cells. European Journal of Immunology. 37: S103-10. PMID 17972353 DOI: 10.1002/Eji.200737584 |
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Crawford A, Wherry EJ. Inhibitory receptors: whose side are they on? Nature Immunology. 8: 1201-3. PMID 17952048 DOI: 10.1038/Ni1107-1201 |
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Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H, Wherry EJ, Reiner SL. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. The Journal of Experimental Medicine. 204: 2015-21. PMID 17698591 DOI: 10.1084/Jem.20070841 |
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Shin H, Wherry EJ. CD8 T cell dysfunction during chronic viral infection. Current Opinion in Immunology. 19: 408-15. PMID 17656078 DOI: 10.1016/J.Coi.2007.06.004 |
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Tatsis N, Fitzgerald JC, Reyes-Sandoval A, Harris-McCoy KC, Hensley SE, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood. 110: 1916-23. PMID 17510320 DOI: 10.1182/Blood-2007-02-062117 |
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Shin H, Blackburn SD, Blattman JN, Wherry EJ. Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. The Journal of Experimental Medicine. 204: 941-9. PMID 17420267 DOI: 10.1084/Jem.20061937 |
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Blackburn SD, Wherry EJ. IL-10, T cell exhaustion and viral persistence. Trends in Microbiology. 15: 143-146. PMID 17336072 DOI: 10.1016/J.Tim.2007.02.006 |
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Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nature Immunology. 8: 239-45. PMID 17304234 DOI: 10.1038/Ni1443 |
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Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, Hanson HL, Steinberg JP, Masopust D, Wherry EJ, Altman JD, Rouse BT, Freeman GJ, Ahmed R, Grakoui A. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. Journal of Virology. 81: 2545-53. PMID 17182670 DOI: 10.1128/Jvi.02021-06 |
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Takemoto N, Intlekofer AM, Northrup JT, Wherry EJ, Reiner SL. Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 177: 7515-9. PMID 17114419 DOI: 10.4049/Jimmunol.177.11.7515 |
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Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. The Journal of Experimental Medicine. 203: 2223-7. PMID 17000870 DOI: 10.1084/Jem.20061800 |
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Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD. HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. Virology. 353: 366-73. PMID 16860834 DOI: 10.1016/J.Virol.2006.06.017 |
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Intlekofer AM, Wherry EJ, Reiner SL. Not-so-great expectations: re-assessing the essence of T-cell memory. Immunological Reviews. 211: 203-13. PMID 16824129 DOI: 10.1111/J.0105-2896.2006.00396.X |
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Crotty S, McCausland MM, Aubert RD, Wherry EJ, Ahmed R. Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease. Blood. 108: 3085-93. PMID 16788096 DOI: 10.1182/Blood-2006-04-018929 |
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Wherry EJ, Golovina TN, Morrison SE, Sinnathamby G, McElhaugh MJ, Shockey DC, Eisenlohr LC. Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope. Journal of Immunology (Baltimore, Md. : 1950). 176: 2249-61. PMID 16455981 DOI: 10.4049/Jimmunol.176.4.2249 |
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Masopust D, Vezys V, Wherry EJ, Barber DL, Ahmed R. Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. Journal of Immunology (Baltimore, Md. : 1950). 176: 2079-83. PMID 16455963 DOI: 10.4049/Jimmunol.176.4.2079 |
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Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Erratum: Corrigendum: Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Nature Immunology. 7: 113-113. DOI: 10.1038/Ni0106-113 |
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Haining WN, Ebert B, Subramanian A, Kaech S, Ahmed R, Nadler L, Wherry EJ, Golub T. Su.66. Memory T-Cells in Mice and Humans Share a Common Molecular Program of Differentiation Regardless of Phenotype, Lineage Or Species Clinical Immunology. 119: S182-S183. DOI: 10.1016/J.Clim.2006.04.493 |
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Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/Ni1268 |
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Wherry EJ, Blattman JN, Ahmed R. Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. Journal of Virology. 79: 8960-8. PMID 15994790 DOI: 10.1128/Jvi.79.14.8960-8968.2005 |
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Miller JD, Masopust D, Wherry EJ, Kaech S, Silvestri G, Ahmed R. Differentiation of CD8 T cells in response to acute and chronic viral infections: Implications for HIV vaccine development Current Drug Targets - Infectious Disorders. 5: 121-129. PMID 15975018 DOI: 10.2174/1568005054201544 |
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| 2005 |
Becker TC, Coley SM, Wherry EJ, Ahmed R. Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 174: 1269-73. PMID 15661882 DOI: 10.4049/Jimmunol.174.3.1269 |
0.818 |
|
| 2005 |
Haining WN, Ebert B, Subramanian A, Kaech S, Nadler L, Golub T, Wherry EJ. Transcriptional Mapping of T Cell Memory Reveals That Chronic Viral Infection Arrests Memory Differentiation. Blood. 106: 328-328. DOI: 10.1182/Blood.V106.11.328.328 |
0.772 |
|
| 2004 |
Mandal M, Kawamura KS, Wherry EJ, Ahmed R, Lee KD. Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity. Molecular Pharmaceutics. 1: 2-8. PMID 15832496 DOI: 10.1021/Mp034021M |
0.578 |
|
| 2004 |
Gourley TS, Wherry EJ, Masopust D, Ahmed R. Generation and maintenance of immunological memory. Seminars in Immunology. 16: 323-33. PMID 15528077 DOI: 10.1016/J.Smim.2004.08.013 |
0.646 |
|
| 2004 |
Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 101: 16004-9. PMID 15505208 DOI: 10.1073/Pnas.0407192101 |
0.878 |
|
| 2004 |
Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. Journal of Virology. 78: 5535-45. PMID 15140950 DOI: 10.1128/Jvi.78.11.5535-5545.2004 |
0.742 |
|
| 2004 |
Wu Z, Roberts M, Porter M, Walker F, Wherry EJ, Kelly J, Gadina M, Silva EM, DosReis GA, Lopes MF, O'Shea J, Leonard WJ, Ahmed R, Siegel RM. Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. Journal of Immunology (Baltimore, Md. : 1950). 172: 6313-23. PMID 15128821 DOI: 10.4049/Jimmunol.172.10.6313 |
0.766 |
|
| 2004 |
Masopust D, Kaech SM, Wherry EJ, Ahmed R. The role of programming in memory T-cell development. Current Opinion in Immunology. 16: 217-25. PMID 15023416 DOI: 10.1016/J.Coi.2004.02.005 |
0.773 |
|
| 2003 |
Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunology. 4: 1191-8. PMID 14625547 DOI: 10.1038/Ni1009 |
0.766 |
|
| 2003 |
van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Sette A, Ahmed R. Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology. 315: 93-102. PMID 14592762 DOI: 10.1016/J.Virol.2003.07.001 |
0.836 |
|
| 2003 |
Barber DL, Wherry EJ, Ahmed R. Cutting edge: rapid in vivo killing by memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 27-31. PMID 12816979 DOI: 10.4049/Jimmunol.171.1.27 |
0.753 |
|
| 2003 |
Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. Heterologous immunity provides a potent barrier to transplantation tolerance. The Journal of Clinical Investigation. 111: 1887-95. PMID 12813024 DOI: 10.1172/Jci17477 |
0.842 |
|
| 2003 |
Kersh EN, Kaech SM, Onami TM, Moran M, Wherry EJ, Miceli MC, Ahmed R. TCR signal transduction in antigen-specific memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 5455-63. PMID 12759421 DOI: 10.4049/Jimmunol.170.11.5455 |
0.8 |
|
| 2003 |
Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nature Medicine. 9: 540-7. PMID 12692546 DOI: 10.1038/Nm866 |
0.826 |
|
| 2003 |
Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. Journal of Virology. 77: 4911-27. PMID 12663797 DOI: 10.1128/Jvi.77.8.4911-4927.2003 |
0.851 |
|
| 2003 |
Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunology. 4: 225-34. PMID 12563257 DOI: 10.1038/Ni889 |
0.852 |
|
| 2002 |
Wherry EJ, Becker TC, Boone D, Kaja MK, Ma A, Ahmed R. Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha. Advances in Experimental Medicine and Biology. 512: 165-75. PMID 12405201 DOI: 10.1007/978-1-4615-0757-4_22 |
0.819 |
|
| 2002 |
Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R. Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. Journal of Immunology (Baltimore, Md. : 1950). 169: 3760-70. PMID 12244170 DOI: 10.4049/Jimmunol.169.7.3760 |
0.867 |
|
| 2002 |
Becker TC, Wherry EJ, Boone D, Murali-Krishna K, Antia R, Ma A, Ahmed R. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. The Journal of Experimental Medicine. 195: 1541-8. PMID 12070282 DOI: 10.1084/Jem.20020369 |
0.831 |
|
| 2002 |
Kaech SM, Wherry EJ, Ahmed R. Effector and memory T-cell differentiation: implications for vaccine development. Nature Reviews. Immunology. 2: 251-62. PMID 12001996 DOI: 10.1038/Nri778 |
0.791 |
|
| 2002 |
Wherry EJ, McElhaugh MJ, Eisenlohr LC. Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope. Journal of Immunology (Baltimore, Md. : 1950). 168: 4455-61. PMID 11970989 DOI: 10.4049/Jimmunol.168.9.4455 |
0.509 |
|
| 1999 |
Wherry EJ, Puorro KA, Porgador A, Eisenlohr LC. The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained. Journal of Immunology (Baltimore, Md. : 1950). 163: 3735-45. PMID 10490969 |
0.48 |
|
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