| Year |
Citation |
Score |
| 2024 |
Couce A, Limdi A, Magnan M, Owen SV, Herren CM, Lenski RE, Tenaillon O, Baym M. Changing fitness effects of mutations through long-term bacterial evolution. Science (New York, N.Y.). 383: eadd1417. PMID 38271521 DOI: 10.1126/science.add1417 |
0.447 |
|
| 2023 |
Choudhury A, Gachet B, Dixit Z, Faure R, Gill RT, Tenaillon O. Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs. Nature Communications. 14: 6319. PMID 37813857 DOI: 10.1038/s41467-023-41882-7 |
0.398 |
|
| 2023 |
Vigué L, Tenaillon O. Predicting the effect of mutations to investigate recent events of selection across 60,472 strains. Proceedings of the National Academy of Sciences of the United States of America. 120: e2304177120. PMID 37487088 DOI: 10.1073/pnas.2304177120 |
0.39 |
|
| 2022 |
Tenaillon O, Matic I. [The impact of neutral mutations on genome evolvability]. Medecine Sciences : M/S. 38: 777-785. PMID 36219077 DOI: 10.1051/medsci/2022122 |
0.482 |
|
| 2022 |
Vigué L, Croce G, Petitjean M, Ruppé E, Tenaillon O, Weigt M. Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes. Nature Communications. 13: 4030. PMID 35821377 DOI: 10.1038/s41467-022-31643-3 |
0.319 |
|
| 2022 |
Birgy A, Magnan M, Hobson CA, Figliuzzi M, Panigoni K, Codde C, Tenaillon O, Jacquier H. Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1. Antibiotics (Basel, Switzerland). 11. PMID 35625296 DOI: 10.3390/antibiotics11050652 |
0.326 |
|
| 2021 |
Consuegra J, Gaffé J, Lenski RE, Hindré T, Barrick JE, Tenaillon O, Schneider D. Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria. Nature Communications. 12: 980. PMID 33579917 DOI: 10.1038/s41467-021-21210-7 |
0.502 |
|
| 2021 |
Bridier-Nahmias A, Launay A, Bleibtreu A, Magnan M, Walewski V, Chatel J, Dion S, Robbe-Saule V, Clermont O, Norel F, Denamur E, Tenaillon O. Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play. Msphere. 6. PMID 33408235 DOI: 10.1128/mSphere.01176-20 |
0.418 |
|
| 2020 |
Escudero JA, Nivina A, Kemble HE, Loot C, Tenaillon O, Mazel D. Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions. Elife. 9. PMID 33319743 DOI: 10.7554/eLife.58061 |
0.313 |
|
| 2020 |
Kemble H, Eisenhauer C, Couce A, Chapron A, Magnan M, Gautier G, Le Nagard H, Nghe P, Tenaillon O. Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway. Science Advances. 6: eabb2236. PMID 32537514 DOI: 10.1126/Sciadv.Abb2236 |
0.375 |
|
| 2020 |
Tenaillon O, Matic I. The Impact of Neutral Mutations on Genome Evolvability. Current Biology : Cb. 30: R527-R534. PMID 32428494 DOI: 10.1016/J.Cub.2020.03.056 |
0.565 |
|
| 2020 |
Caméléna F, Morel F, Merimèche M, Decousser JW, Jacquier H, Clermont O, Darty M, Mainardis M, Cambau E, Tenaillon O, Denamur E, Berçot B. Genomic characterization of 16S rRNA methyltransferase-producing Escherichia coli isolates from the Parisian area, France. The Journal of Antimicrobial Chemotherapy. PMID 32300786 DOI: 10.1093/Jac/Dkaa105 |
0.301 |
|
| 2020 |
Choudhury A, Fenster JA, Fankhauser RG, Kaar JL, Tenaillon O, Gill RT. CRISPR/Cas9 recombineering-mediated deep mutational scanning of essential genes in Escherichia coli. Molecular Systems Biology. 16: e9265. PMID 32175691 DOI: 10.15252/Msb.20199265 |
0.535 |
|
| 2020 |
Hobson CA, Bonacorsi S, Hocquet D, Baruchel A, Fahd M, Storme T, Tang R, Doit C, Tenaillon O, Birgy A. Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam. Scientific Reports. 10: 589. PMID 31953453 DOI: 10.1038/S41598-020-57505-W |
0.463 |
|
| 2019 |
Kemble H, Nghe P, Tenaillon O. Recent insights into the genotype-phenotype relationship from massively parallel genetic assays. Evolutionary Applications. 12: 1721-1742. PMID 31548853 DOI: 10.1111/Eva.12846 |
0.428 |
|
| 2019 |
Ghalayini M, Magnan M, Dion S, Zatout O, Bourguignon L, Tenaillon O, Lescat M. Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon. Molecular Ecology. PMID 31482587 DOI: 10.1111/Mec.15232 |
0.404 |
|
| 2019 |
Mahérault AC, Kemble H, Magnan M, Gachet B, Roche D, Nagard HL, Tenaillon O, Denamur E, Branger C, Landraud L. acquisition and evolution of gene bearing plasmids in : advantage of the F2:A1:B- IncF pandemic plasmid over IncC plasmids. Antimicrobial Agents and Chemotherapy. PMID 31332067 DOI: 10.1128/Aac.01130-19 |
0.308 |
|
| 2019 |
Couce A, Tenaillon O. Mutation bias and GC content shape antimutator invasions. Nature Communications. 10: 3114. PMID 31308380 DOI: 10.1038/S41467-019-11217-6 |
0.557 |
|
| 2018 |
Ghalayini M, Launay A, Bridier-Nahmias A, Clermont O, Denamur E, Lescat M, Tenaillon O. Evolution of a Dominant Natural Isolate of Escherichia coli in the Human Gut over the Course of a Year Suggests a Neutral Evolution with Reduced Effective Population Size. Applied and Environmental Microbiology. 84. PMID 29305507 DOI: 10.1128/Aem.02377-17 |
0.495 |
|
| 2017 |
Couce A, Caudwell LV, Feinauer C, Hindré T, Feugeas JP, Weigt M, Lenski RE, Schneider D, Tenaillon O. Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria. Proceedings of the National Academy of Sciences of the United States of America. 114: E9026-E9035. PMID 29073099 DOI: 10.1073/Pnas.1705887114 |
0.585 |
|
| 2017 |
Bosshard L, Dupanloup I, Tenaillon O, Bruggmann R, Ackermann M, Peischl S, Excoffier L. Accumulation of Deleterious Mutations During Bacterial Range Expansions. Genetics. PMID 28821588 DOI: 10.1534/Genetics.117.300144 |
0.549 |
|
| 2017 |
Lescat M, Launay A, Ghalayini M, Magnan M, Glodt J, Pintard C, Dion S, Denamur E, Tenaillon O. Using long-term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin-treated mouse gut. Molecular Ecology. 26: 1802-1817. PMID 27661780 DOI: 10.1111/Mec.13851 |
0.56 |
|
| 2016 |
Tenaillon O, Barrick JE, Ribeck N, Deatherage DE, Blanchard JL, Dasgupta A, Wu GC, Wielgoss S, Cruveiller S, Médigue C, Schneider D, Lenski RE. Tempo and mode of genome evolution in a 50,000-generation experiment. Nature. PMID 27479321 DOI: 10.1038/Nature18959 |
0.742 |
|
| 2016 |
Feugeas JP, Tourret J, Launay A, Bouvet O, Hoede C, Denamur E, Tenaillon O. Links between Transcription, Environmental Adaptation and Gene Variability in Escherichia coli: Correlations between Gene Expression and Gene Variability Reflect Growth Efficiencies. Molecular Biology and Evolution. 33: 2515-29. PMID 27352853 DOI: 10.1093/Molbev/Msw105 |
0.35 |
|
| 2016 |
Figliuzzi M, Jacquier H, Schug A, Tenaillon O, Weigt M. Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 Molecular Biology and Evolution. 33: 268-280. PMID 26446903 DOI: 10.1093/Molbev/Msv211 |
0.488 |
|
| 2015 |
Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Achard H, Denamur M, Cywes-Bentley C, ... ... Tenaillon O, et al. Emergence of Antimicrobial Resistant Escherichia coli of Animal Origin Spreading in Humans. Molecular Biology and Evolution. PMID 26613786 DOI: 10.1093/Molbev/Msv280 |
0.357 |
|
| 2015 |
Rodríguez-Verdugo A, Tenaillon O, Gaut BS. First-step mutations during adaptation restore the expression of hundreds of genes. Molecular Biology and Evolution. PMID 26500250 DOI: 10.1093/Molbev/Msv228 |
0.498 |
|
| 2015 |
Long A, Liti G, Luptak A, Tenaillon O. Elucidating the molecular architecture of adaptation via evolve and resequence experiments. Nature Reviews. Genetics. PMID 26347030 DOI: 10.1038/Nrg3937 |
0.382 |
|
| 2015 |
Rodríguez-Beltrán J, Tourret J, Tenaillon O, López E, Bourdelier E, Costas C, Matic I, Denamur E, Blázquez J. High Recombinant Frequency in Extraintestinal Pathogenic Escherichia coli Strains. Molecular Biology and Evolution. 32: 1708-16. PMID 25804522 DOI: 10.1093/Molbev/Msv072 |
0.423 |
|
| 2014 |
Blanquart F, Achaz G, Bataillon T, Tenaillon O. Properties of selected mutations and genotypic landscapes under Fisher's geometric model. Evolution; International Journal of Organic Evolution. 68: 3537-54. PMID 25311558 DOI: 10.1111/Evo.12545 |
0.488 |
|
| 2014 |
Lescat M, Reibel F, Pintard C, Dion S, Glodt J, Gateau C, Launay A, Ledda A, Cruvellier S, Tourret J, Tenaillon O. The conserved nhaAR operon is drastically divergent between B2 and non-B2 Escherichia coli and is involved in extra-intestinal virulence. Plos One. 9: e108738. PMID 25268639 DOI: 10.1371/Journal.Pone.0108738 |
0.343 |
|
| 2014 |
Raeside C, Gaffé J, Deatherage DE, Tenaillon O, Briska AM, Ptashkin RN, Cruveiller S, Médigue C, Lenski RE, Barrick JE, Schneider D. Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli. Mbio. 5: e01377-14. PMID 25205090 DOI: 10.1128/Mbio.01377-14 |
0.424 |
|
| 2014 |
Plucain J, Hindré T, Le Gac M, Tenaillon O, Cruveiller S, Médigue C, Leiby N, Harcombe WR, Marx CJ, Lenski RE, Schneider D. Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli. Science (New York, N.Y.). 343: 1366-9. PMID 24603152 DOI: 10.1126/Science.1248688 |
0.543 |
|
| 2014 |
Achaz G, Rodriguez-Verdugo A, Gaut BS, Tenaillon O. The reproducibility of adaptation in the light of experimental evolution with whole genome sequencing. Advances in Experimental Medicine and Biology. 781: 211-31. PMID 24277302 DOI: 10.1007/978-94-007-7347-9_11 |
0.447 |
|
| 2013 |
DÃaz-Muñoz SL, Tenaillon O, Goldhill D, Brao K, Turner PE, Chao L. Electrophoretic mobility confirms reassortment bias among geographic isolates of segmented RNA phages. Bmc Evolutionary Biology. 13: 206. PMID 24059872 DOI: 10.1186/1471-2148-13-206 |
0.412 |
|
| 2013 |
Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O. Capturing the mutational landscape of the beta-lactamase TEM-1. Proceedings of the National Academy of Sciences of the United States of America. 110: 13067-72. PMID 23878237 DOI: 10.1073/Pnas.1215206110 |
0.519 |
|
| 2013 |
Maharjan RP, Gaffé J, Plucain J, Schliep M, Wang L, Feng L, Tenaillon O, Ferenci T, Schneider D. A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli. Bmc Genomics. 14: 441. PMID 23822838 DOI: 10.1186/1471-2164-14-441 |
0.417 |
|
| 2013 |
Bleibtreu A, Gros PA, Laouénan C, Clermont O, Le Nagard H, Picard B, Tenaillon O, Denamur E. Fitness, stress resistance, and extraintestinal virulence in Escherichia coli. Infection and Immunity. 81: 2733-42. PMID 23690401 DOI: 10.1128/Iai.01329-12 |
0.344 |
|
| 2013 |
Rodríguez-Verdugo A, Gaut BS, Tenaillon O. Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress. Bmc Evolutionary Biology. 13: 50. PMID 23433244 DOI: 10.1186/1471-2148-13-50 |
0.523 |
|
| 2013 |
Wielgoss S, Barrick JE, Tenaillon O, Wiser MJ, Dittmar WJ, Cruveiller S, Chane-Woon-Ming B, Médigue C, Lenski RE, Schneider D. Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load. Proceedings of the National Academy of Sciences of the United States of America. 110: 222-7. PMID 23248287 DOI: 10.1073/Pnas.1219574110 |
0.739 |
|
| 2012 |
Tenaillon O, Rodríguez-Verdugo A, Gaut RL, McDonald P, Bennett AF, Long AD, Gaut BS. The molecular diversity of adaptive convergence. Science (New York, N.Y.). 335: 457-61. PMID 22282810 DOI: 10.1126/Science.1212986 |
0.564 |
|
| 2011 |
Wielgoss S, Barrick JE, Tenaillon O, Cruveiller S, Chane-Woon-Ming B, Médigue C, Lenski RE, Schneider D. Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli. G3 (Bethesda, Md.). 1: 183-186. PMID 22207905 DOI: 10.1534/G3.111.000406 |
0.712 |
|
| 2011 |
Le Nagard H, Chao L, Tenaillon O. The emergence of complexity and restricted pleiotropy in adapting networks. Bmc Evolutionary Biology. 11: 326. PMID 22059952 DOI: 10.1186/1471-2148-11-326 |
0.318 |
|
| 2011 |
Billard-Pomares T, Tenaillon O, Le Nagard H, Rouy Z, Cruveiller S, Médigue C, Arlet G, Denamur E, Branger C. Complete nucleotide sequence of plasmid pTN48, encoding the CTX-M-14 extended-spectrum β-lactamase from an Escherichia coli O102-ST405 strain. Antimicrobial Agents and Chemotherapy. 55: 1270-3. PMID 21173179 DOI: 10.1128/Aac.01108-10 |
0.313 |
|
| 2010 |
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, Balliau T, Zivy M, Le Nagard H, Cruveiller S, Cruvellier S, ... ... Tenaillon O, et al. Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections. Plos Pathogens. 6: e1001125. PMID 20941353 DOI: 10.1371/Journal.Ppat.1001125 |
0.391 |
|
| 2010 |
Tenaillon O, Skurnik D, Picard B, Denamur E. The population genetics of commensal Escherichia coli. Nature Reviews. Microbiology. 8: 207-17. PMID 20157339 DOI: 10.1038/Nrmicro2298 |
0.373 |
|
| 2009 |
Lescat M, Calteau A, Hoede C, Barbe V, Touchon M, Rocha E, Tenaillon O, Médigue C, Johnson JR, Denamur E. A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A. Antimicrobial Agents and Chemotherapy. 53: 2283-8. PMID 19364861 DOI: 10.1128/Aac.00123-09 |
0.383 |
|
| 2009 |
Gros PA, Tenaillon O. Selection for chaperone-like mediated genetic robustness at low mutation rate: impact of drift, epistasis and complexity. Genetics. 182: 555-64. PMID 19307609 DOI: 10.1534/genetics.108.099366 |
0.41 |
|
| 2009 |
Gros PA, Le Nagard H, Tenaillon O. The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation. Genetics. 182: 277-93. PMID 19279327 DOI: 10.1534/Genetics.108.099127 |
0.5 |
|
| 2009 |
Touchon M, Hoede C, Tenaillon O, Barbe V, Baeriswyl S, Bidet P, Bingen E, Bonacorsi S, Bouchier C, Bouvet O, Calteau A, Chiapello H, Clermont O, Cruveiller S, Danchin A, et al. Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths. Plos Genetics. 5: e1000344. PMID 19165319 DOI: 10.1371/Journal.Pgen.1000344 |
0.444 |
|
| 2009 |
Schubert S, Darlu P, Clermont O, Wieser A, Magistro G, Hoffmann C, Weinert K, Tenaillon O, Matic I, Denamur E. Role of intraspecies recombination in the spread of pathogenicity islands within the Escherichia coli species. Plos Pathogens. 5: e1000257. PMID 19132082 DOI: 10.1371/Journal.Ppat.1000257 |
0.335 |
|
| 2008 |
Clermont O, Lescat M, O'Brien CL, Gordon DM, Tenaillon O, Denamur E. Evidence for a human-specific Escherichia coli clone. Environmental Microbiology. 10: 1000-6. PMID 18177373 DOI: 10.1111/J.1462-2920.2007.01520.X |
0.301 |
|
| 2008 |
Marais GA, Calteau A, Tenaillon O. Mutation rate and genome reduction in endosymbiotic and free-living bacteria. Genetica. 134: 205-10. PMID 18046510 DOI: 10.1007/S10709-007-9226-6 |
0.442 |
|
| 2007 |
Le Gall T, Clermont O, Gouriou S, Picard B, Nassif X, Denamur E, Tenaillon O. Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains. Molecular Biology and Evolution. 24: 2373-84. PMID 17709333 DOI: 10.1093/Molbev/Msm172 |
0.368 |
|
| 2007 |
Nora T, Charpentier C, Tenaillon O, Hoede C, Clavel F, Hance AJ. Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment. Journal of Virology. 81: 7620-8. PMID 17494080 DOI: 10.1128/Jvi.00083-07 |
0.456 |
|
| 2007 |
Silander OK, Tenaillon O, Chao L. Understanding the evolutionary fate of finite populations: the dynamics of mutational effects. Plos Biology. 5: e94. PMID 17407380 DOI: 10.1371/Journal.Pbio.0050094 |
0.539 |
|
| 2007 |
Tenaillon O, Silander OK, Uzan JP, Chao L. Quantifying organismal complexity using a population genetic approach. Plos One. 2: e217. PMID 17299597 DOI: 10.1371/Journal.Pone.0000217 |
0.326 |
|
| 2006 |
Hoede C, Denamur E, Tenaillon O. Selection acts on DNA secondary structures to decrease transcriptional mutagenesis. Plos Genetics. 2: e176. PMID 17083275 DOI: 10.1371/Journal.Pgen.0020176 |
0.465 |
|
| 2006 |
Charpentier C, Nora T, Tenaillon O, Clavel F, Hance AJ. Extensive recombination among human immunodeficiency virus type 1 quasispecies makes an important contribution to viral diversity in individual patients. Journal of Virology. 80: 2472-82. PMID 16474154 DOI: 10.1128/Jvi.80.5.2472-2482.2006 |
0.369 |
|
| 2005 |
Montville R, Froissart R, Remold SK, Tenaillon O, Turner PE. Evolution of mutational robustness in an RNA virus. Plos Biology. 3: e381. PMID 16248678 DOI: 10.1371/Journal.Pbio.0030381 |
0.516 |
|
| 2005 |
Denamur E, Tenaillon O, Deschamps C, Skurnik D, Ronco E, Gaillard JL, Picard B, Branger C, Matic I. Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli. Genetics. 171: 825-7. PMID 15965238 DOI: 10.1534/Genetics.105.045526 |
0.473 |
|
| 2004 |
Tenaillon O, Denamur E, Matic I. Evolutionary significance of stress-induced mutagenesis in bacteria. Trends in Microbiology. 12: 264-70. PMID 15165604 DOI: 10.1016/J.Tim.2004.04.002 |
0.376 |
|
| 2004 |
Tenaillon MI, U'Ren J, Tenaillon O, Gaut BS. Selection versus demography: a multilocus investigation of the domestication process in maize. Molecular Biology and Evolution. 21: 1214-25. PMID 15014173 DOI: 10.1093/Molbev/Msh102 |
0.363 |
|
| 2003 |
Bjedov I, Tenaillon O, Gérard B, Souza V, Denamur E, Radman M, Taddei F, Matic I. Stress-induced mutagenesis in bacteria. Science (New York, N.Y.). 300: 1404-9. PMID 12775833 DOI: 10.1126/Science.1082240 |
0.4 |
|
| 2003 |
Bjedov I, Lecointre G, Tenaillon O, Vaury C, Radman M, Taddei F, Denamur E, Matic I. Polymorphism of genes encoding SOS polymerases in natural populations of Escherichia coli. Dna Repair. 2: 417-26. PMID 12606122 DOI: 10.1016/S1568-7864(02)00241-0 |
0.334 |
|
| 2001 |
Giraud A, Matic I, Tenaillon O, Clara A, Radman M, Fons M, Taddei F. Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut. Science (New York, N.Y.). 291: 2606-8. PMID 11283373 DOI: 10.1126/Science.1056421 |
0.551 |
|
| 2001 |
Tenaillon O, Taddei F, Radmian M, Matic I. Second-order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of adaptation. Research in Microbiology. 152: 11-6. PMID 11281320 DOI: 10.1016/S0923-2508(00)01163-3 |
0.52 |
|
| 2000 |
Denamur E, Lecointre G, Darlu P, Tenaillon O, Acquaviva C, Sayada C, Sunjevaric I, Rothstein R, Elion J, Taddei F, Radman M, Matic I. Evolutionary implications of the frequent horizontal transfer of mismatch repair genes. Cell. 103: 711-21. PMID 11114328 DOI: 10.1016/S0092-8674(00)00175-6 |
0.529 |
|
| 2000 |
Tenaillon O, Le Nagard H, Godelle B, Taddei F. Mutators and sex in bacteria: conflict between adaptive strategies. Proceedings of the National Academy of Sciences of the United States of America. 97: 10465-70. PMID 10973474 DOI: 10.1073/Pnas.180063397 |
0.496 |
|
| 1999 |
Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B. Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria. Genetics. 152: 485-93. PMID 10353893 |
0.471 |
|
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