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Vladimir Yarov-Yarovoy - Publications

Affiliations: 
University of California, Davis, Davis, CA 
Area:
Ion channels, membrane proteins, computational protein structure prediction and design
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131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Woltz RL, Zheng Y, Choi W, Ngo K, Trinh P, Ren L, Thai PN, Harris BJ, Han Y, Rouen KC, Mateos DL, Jian Z, Chen-Izu Y, Dickson EJ, Yamoah EN, ... Yarov-Yarovoy V, et al. Atomistic mechanisms of the regulation of small-conductance Ca-activated K channel (SK2) by PIP2. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318900121. PMID 39288178 DOI: 10.1073/pnas.2318900121  0.459
2024 Harris BJ, Nguyen PT, Zhou G, Wulff H, DiMaio F, Yarov-Yarovoy V. Toward high-resolution modeling of small molecule-ion channel interactions. Frontiers in Pharmacology. 15: 1411428. PMID 38919257 DOI: 10.3389/fphar.2024.1411428  0.411
2024 Nguyen PT, Harris BJ, Mateos DL, González AH, Murray AM, Yarov-Yarovoy V. Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold. Channels (Austin, Tex.). 18: 2325032. PMID 38445990 DOI: 10.1080/19336950.2024.2325032  0.458
2024 Ngo K, Yarov-Yarovoy V, Clancy CE, Vorobyov I. Harnessing AlphaFold to reveal state secrets: Prediction of hERG closed and inactivated states. Biorxiv : the Preprint Server For Biology. PMID 38352360 DOI: 10.1101/2024.01.27.577468  0.3
2023 Ngo K, Lopez Mateos D, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel. The Journal of General Physiology. 156. PMID 38127314 DOI: 10.1085/jgp.202313368  0.391
2023 Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of hERG channel-drug interactions using Rosetta. Frontiers in Pharmacology. 14: 1244166. PMID 38035013 DOI: 10.3389/fphar.2023.1244166  0.468
2023 Ng LC, Harris BJ, Larmore M, Ta MC, Vien TN, Tokars VL, Yarov-Yarovoy V, DeCaen PG. Energetic landscape of polycystin channel gating. Embo Reports. e56783. PMID 37158562 DOI: 10.15252/embr.202356783  0.455
2023 Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na1.7. Frontiers in Pharmacology. 14: 1156855. PMID 37007002 DOI: 10.3389/fphar.2023.1156855  0.45
2023 Ngo K, Mateos DL, Rouen K, Han Y, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na 1.7 Channel. Biorxiv : the Preprint Server For Biology. PMID 36909474 DOI: 10.1101/2023.02.27.530360  0.418
2023 Li S, Nguyen PT, Vu S, Yarov-Yarovoy V, Zheng J. TRPV1 Opening is Stabilized Equally by Its Four Subunits. Biorxiv : the Preprint Server For Biology. PMID 36747729 DOI: 10.1101/2023.01.26.525787  0.303
2023 Mateos DL, Yarov-Yarovoy V. Structural modeling of peptide toxin-ion channel interactions using RosettaDock. Proteins. PMID 36729043 DOI: 10.1002/prot.26474  0.378
2022 Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463  0.479
2022 Mazola Y, Márquez Montesinos JCE, Ramírez D, Zúñiga L, Decher N, Ravens U, Yarov-Yarovoy V, González W. Common Structural Pattern for Flecainide Binding in Atrial-Selective K1.5 and Na1.5 Channels: A Computational Approach. Pharmaceutics. 14. PMID 35890252 DOI: 10.3390/pharmaceutics14071356  0.369
2022 George K, Lopez-Mateos D, Abd El-Aziz TM, Xiao Y, Kline J, Bao H, Raza S, Stockand JD, Cummins TR, Fornelli L, Rowe MP, Yarov-Yarovoy V, Rowe AH. Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits Na1.8 via Interactions With the DI Voltage Sensor and DII Pore Module. Frontiers in Pharmacology. 13: 846992. PMID 35662692 DOI: 10.3389/fphar.2022.846992  0.421
2022 Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. Structural insights into TRPV2 activation by small molecules. Nature Communications. 13: 2334. PMID 35484159 DOI: 10.1038/s41467-022-30083-3  0.337
2022 Nguyen PT, Yarov-Yarovoy V. Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels. Frontiers in Pharmacology. 13: 842032. PMID 35153801 DOI: 10.3389/fphar.2022.842032  0.32
2020 Ledford HA, Park S, Muir D, Woltz RL, Ren L, Nguyen PT, Sirish P, Wang W, Sihn CR, George AL, Knollmann BC, Yamoah EN, Yarov-Yarovoy V, Zhang XD, Chiamvimonvat N. Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation. The Journal of General Physiology. 152. PMID 33211795 DOI: 10.1085/jgp.202012667  0.4
2020 Yang F, Xu L, Lee BH, Xiao X, Yarov-Yarovoy V, Zheng J. An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 2000575. PMID 33101845 DOI: 10.1002/advs.202000575  0.439
2020 Li G, Woltz RL, Wang CY, Ren L, He PX, Yu SD, Liu XQ, Yarov-Yarovoy V, Hu D, Chiamvimonvat N, Wu L. Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3. Frontiers in Pharmacology. 11: 1182. PMID 32848785 DOI: 10.3389/Fphar.2020.01182  0.363
2020 Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. Acs Chemical Neuroscience. PMID 32579336 DOI: 10.1021/Acschemneuro.0C00276  0.547
2020 Perez-Flores MC, Lee JH, Park S, Zhang XD, Sihn CR, Ledford HA, Wang W, Kim HJ, Timofeyev V, Yarov-Yarovoy V, Chiamvimonvat N, Rabbitt RD, Yamoah EN. Cooperativity of K7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. Science Advances. 6: eaba1104. PMID 32285007 DOI: 10.1126/Sciadv.Aba1104  0.451
2020 Rudell JC, Borges LS, Yarov-Yarovoy V, Ferns M. The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. Frontiers in Molecular Neuroscience. 13: 48. PMID 32265653 DOI: 10.3389/Fnmol.2020.00048  0.322
2020 Yang PC, DeMarco KR, Aghasafari P, Jeng MT, Dawson JR, Bekker S, Noskov S, Yarov-Yarovoy V, Vorobyov I, Clancy CE. A Computational Pipeline to Predict Cardiotoxicity:From the Atom to the Rhythm. Circulation Research. PMID 32091972 DOI: 10.1161/Circresaha.119.316404  0.367
2020 Craig RA, Garrison CE, Nguyen PT, Yarov-Yarovoy V, Du Bois J. Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels. Acs Chemical Neuroscience. PMID 31951114 DOI: 10.1021/Acschemneuro.9B00621  0.511
2020 Emigh AM, DeMarco K, Furutani K, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Predicting Arrhythmogenicity: Structural Modeling of Safe and Unsafe hERG Blockers Biophysical Journal. 118: 117a. DOI: 10.1016/J.Bpj.2019.11.779  0.302
2020 Harris BJ, Nguyen PT, Yarov-Yarovoy V. Structural Modeling of Ion Channel - Small Molecule Interactions using Rosetta's Galiganddock Biophysical Journal. 118: 587a. DOI: 10.1016/J.Bpj.2019.11.3183  0.468
2020 Thapa P, Fletcher-Taylor S, Sepela RJ, Yarov-Yarovoy V, Sack JT, Cohen BE. Observation of Multiple Potassium Channel Closed State Structures by Voltage Clamp Spectroscopy Biophysical Journal. 118: 262a. DOI: 10.1016/J.Bpj.2019.11.1520  0.515
2020 Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 118: 212a. DOI: 10.1016/J.Bpj.2019.11.1265  0.484
2019 Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. The Trials and Tribulations of Structure Assisted Design of K Channel Activators. Frontiers in Pharmacology. 10: 972. PMID 31616290 DOI: 10.3389/Fphar.2019.00972  0.439
2019 Yarov-Yarovoy V, DeCaen P. The Sodium Channel Voltage Sensor Slides to Rest. Trends in Pharmacological Sciences. PMID 31495454 DOI: 10.1016/J.Tips.2019.08.009  0.486
2019 Ng LCT, Vien TN, Yarov-Yarovoy V, DeCaen PG. Opening TRPP2 () requires the transfer of gating charges. Proceedings of the National Academy of Sciences of the United States of America. PMID 31315976 DOI: 10.1073/Pnas.1902917116  0.547
2019 Dong Y, Yin Y, Vu S, Yang F, Yarov-Yarovoy V, Tian Y, Zheng J. A distinct structural mechanism underlies TRPV1 activation by piperine. Biochemical and Biophysical Research Communications. PMID 31213294 DOI: 10.1016/J.Bbrc.2019.06.039  0.486
2019 Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Antibodies and venom peptides: new modalities for ion channels. Nature Reviews. Drug Discovery. PMID 30728472 DOI: 10.1038/S41573-019-0013-8  0.512
2019 Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728299 DOI: 10.1073/Pnas.1817446116  0.406
2019 Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the HERG Channel in an Inactivated State and its Drug Interactions Biophysical Journal. 116: 104a. DOI: 10.1016/j.bpj.2018.11.598  0.397
2019 Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Structural Modeling of Drug Interactions with hERG Channel in Open and Closed States Biophysical Journal. 116: 249a-250a. DOI: 10.1016/J.Bpj.2018.11.1363  0.493
2018 Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J. The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel. Nature Communications. 9: 2879. PMID 30038260 DOI: 10.1016/J.Bpj.2018.11.2439  0.475
2018 Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Assessing the Structural Basis of μ-Conotoxin KIIIA Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.3431  0.517
2018 Ledford HA, Park S, Sirish P, Emigh AM, Xu W, Timofeyev V, Priest JR, Perez MV, Ashley EA, Yarov-Yarovoy V, Zhang X, Chiamvimonvat N. Ring Finger Protein 207 Degrades T613M Kv11.1 Channel Biophysical Journal. 114: 625a. DOI: 10.1016/J.Bpj.2017.11.3379  0.449
2018 Vorobyov I, Brown BM, DeMarco KR, Noskov SY, Yarov-Yarovoy V, Wulff H, Clancy CE. Molecular Determinants of Steroid Hormone and Drug Induced Arrhythmogenesis via hERG Channel Block Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2670  0.451
2018 Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural Modeling of hERG Channel Interactions with Drugs using Rosetta Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2667  0.487
2018 Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of Local Anesthetic and Antiarrhythmic Drug Binding to the Human Cardiac Voltage Gated Sodium Channel Biophysical Journal. 114: 39a. DOI: 10.1016/J.Bpj.2017.11.263  0.499
2018 Shim H, Wulff H, DeMarco K, Yarov-yarovoy V. Structural Modeling of Full-Length KCa Channels using Rosetta Biophysical Journal. 114: 307a. DOI: 10.1016/J.Bpj.2017.11.1743  0.508
2017 Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Molecular Pharmacology. PMID 28760780 DOI: 10.1124/Mol.117.109421  0.433
2017 Tang C, Zhou X, Nguyen PT, Zhang Y, Hu Z, Zhang C, Yarov-Yarovoy V, DeCaen PG, Liang S, Liu Z. A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28400471 DOI: 10.1016/J.Toxicon.2018.10.138  0.512
2017 Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG. Gain-of-Function Mutation of a Voltage-Gated Sodium Channel NaV1.7 Associated with Peripheral Pain and Impaired Limb Development. The Journal of Biological Chemistry. PMID 28381558 DOI: 10.1074/Jbc.M117.778779  0.427
2017 Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Molecular Pharmacology. PMID 28126850 DOI: 10.1124/Mol.116.108068  0.513
2017 Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Allen TW, Yarov-Yarovoy V. An Open State Model of the Navab Channel Explored by Rosetta and Molecular Dynamics Simulation Biophysical Journal. 112: 105a. DOI: 10.1016/J.Bpj.2016.11.599  0.557
2017 DeMarco KR, Nguyen PT, Allen TW, Yarov-Yarovoy V, Clancy CE, Vorobyov I. State-Dependent Structural Modeling and Atomistic Simulations of the hERG Potassium Channel Biophysical Journal. 112: 542a. DOI: 10.1016/J.Bpj.2016.11.2929  0.49
2017 Shim H, Brown B, Nguyen HM, Yarov-Yarovoy V, Wulff H. Rational Design of K Ca 2 Channel Activators Biophysical Journal. 112: 412a-413a. DOI: 10.1016/J.Bpj.2016.11.2567  0.396
2017 Kimball IH, Nguyen PT, Yam J, Pressly B, York R, Sack JT, Yarov-Yarovoy V. Tarantula Toxin SGTx-1 alters Gating Kinetics of Human Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1316  0.57
2016 Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. The Journal of Physiology. PMID 27861921 DOI: 10.1113/Jp272864  0.468
2016 Yang F, Vu S, Yarov-Yarovoy V, Zheng J. Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298359 DOI: 10.1073/Pnas.1604180113  0.517
2016 Brown BM, Shim H, Yarov-Yarovoy V, Wulff H. Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121 Biophysical Journal. 110: 114a. DOI: 10.1016/J.Bpj.2015.11.667  0.477
2016 DeMarco K, Boiteux C, Allen TW, Yarov-Yarovoy V, Clancy CE. Molecular Scale Prediction of Lidocaine Interaction with the Pore Domain of Human Nav1.5 Biophysical Journal. 110: 107a. DOI: 10.1016/J.Bpj.2015.11.636  0.477
2016 Tilley DC, Fleishman S, Sack JT, Yarov-Yarovoy V. What Determines the Charybdotoxin Specificity Among Kv1 Potassium Channels? Biophysical Journal. 110: 106a-107a. DOI: 10.1016/J.Bpj.2015.11.631  0.521
2016 Nguyen D, Yarov-Yarovoy V. Design Principles of Membrane Protein Structures Biophysical Journal. 110: 56a. DOI: 10.1016/J.Bpj.2015.11.367  0.312
2016 Nguyen HM, Singh L, Wulff H, Yarov-Yarovoy V. Validation of KCa3.1 Channel Small Molecules Interaction Sites Predicted by Rosetta Biophysical Journal. 110: 447a. DOI: 10.1016/J.Bpj.2015.11.2405  0.53
2016 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Exploring Structural Interactions of Tarantula Toxins with Lipid Membranes using Rosetta and Molecular Dynamics Simulation Biophysical Journal. 110: 447a. DOI: 10.1016/J.Bpj.2015.11.2404  0.475
2016 Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Mapping the Nav1.7 Channel Interaction with the Conotoxin KIIIA Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2358  0.543
2015 Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE. Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels. Structure (London, England : 1993). PMID 26749449 DOI: 10.1016/J.Str.2015.11.011  0.551
2015 Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. The Journal of Biological Chemistry. PMID 26515070 DOI: 10.1074/Jbc.M115.668236  0.464
2015 Yang S, Yang F, Wei N, Hong J, Li B, Luo L, Rong M, Yarov-Yarovoy V, Zheng J, Wang K, Lai R. A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. Nature Communications. 6: 8297. PMID 26420335 DOI: 10.1038/Ncomms9297  0.446
2015 Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J. A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function. The Journal of Biological Chemistry. 290: 21086-100. PMID 26100638 DOI: 10.1074/Jbc.M115.645671  0.497
2015 Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J. Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nature Chemical Biology. 11: 518-24. PMID 26053297 DOI: 10.1038/Nchembio.1835  0.51
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428  0.472
2015 Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Author response: Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels Elife. DOI: 10.7554/Elife.06774.017  0.431
2015 Wulff H, Yarov-Yarovoy V. Small Molecule Modulation of Voltage-Gated Ion Channels Biophysical Journal. 108: 177a. DOI: 10.1016/J.Bpj.2014.11.977  0.563
2015 Yang F, Xiao X, Cheng W, Yang W, Yarov-Yarovoy V, Zheng J. Molecular Mechanism of TRPV1 Activation by Capsaicin Biophysical Journal. 108: 1-4. DOI: 10.1016/J.Bpj.2014.11.696  0.5
2015 Nguyen HM, Wulff H, Yarov-Yarovoy V. Validation of KCa3.1 Channel Nifedipine Interaction Site Predicted by Rosetta Modeling Method Biophysical Journal. 108: 582a-583a. DOI: 10.1016/J.Bpj.2014.11.3181  0.568
2015 Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW. Sodium Selective Conduction, Inactivation and Inhibition Mechanisms using the Bacterial NavAb Channel Biophysical Journal. 108: 574a. DOI: 10.1016/J.Bpj.2014.11.3141  0.552
2015 Nguyen PT, Kimball IH, Eum KS, Cohen BE, Sack JT, Yarov-Yarovoy V. Understanding the State Dependence of Voltage Sensor Toxin Action on Voltage Gated Sodium Channels Biophysical Journal. 108: 574a. DOI: 10.1016/J.Bpj.2014.11.3139  0.534
2015 Brown BM, Coleman N, Yarov-Yarovoy V, Wulff H. Positive KCa Channel Gating Modulators with Selectivity for KCa3.1 Biophysical Journal. 108: 20a. DOI: 10.1016/J.Bpj.2014.11.134  0.507
2014 Yarov-Yarovoy V, Allen TW, Clancy CE. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discovery Today. Disease Models. 14: 3-10. PMID 26635886 DOI: 10.1016/J.Ddmod.2014.04.001  0.336
2014 Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E4789-96. PMID 25331865 DOI: 10.1073/Pnas.1406876111  0.54
2014 Boiteux C, Vorobyov I, French RJ, French C, Yarov-Yarovoy V, Allen TW. Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 111: 13057-62. PMID 25136136 DOI: 10.1073/Pnas.1408710111  0.563
2014 Rafizadeh S, Zhang Z, Woltz RL, Kim HJ, Myers RE, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yarov-Yarovoy V, Yamoah EN, Chiamvimonvat N. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proceedings of the National Academy of Sciences of the United States of America. 111: 9989-94. PMID 24951510 DOI: 10.1073/Pnas.1323541111  0.5
2014 Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA. Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor (vol 108, pg 15426, 2011) Proceedings of the National Academy of Sciences of the United States of America. 111: 3645-3645. DOI: 10.1073/Pnas.1401985111  0.421
2014 Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE. Residues Critical for Voltage-Sensor Transitions Determining Gating Properties of Cav1.1 Biophysical Journal. 106: 136a. DOI: 10.1016/J.Bpj.2013.11.796  0.516
2014 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of Toxin Interactions with the Human Voltage-Gated Sodium Channel Pore Biophysical Journal. 106: 130a. DOI: 10.1016/J.Bpj.2013.11.768  0.557
2014 Rafizadeh S, Zhang Z, Woltz R, Kim HJ, Lu L, Tuteja D, Singapuri A, Bigdeli AA, Harchache SB, Knowlton AA, Yamoah EN, Yarov-Yarovoy V, Chiamvimonvat N. Functional Interaction with Filamin a Enhances Atrial-Specific Small Conductance Ca2 Activated K+ Channel (SK2) Surface Membrane Expression Biophysical Journal. 106: 118a. DOI: 10.1016/J.Bpj.2013.11.710  0.497
2014 Yang F, Yarov-Yarovoy V, Zheng J. A Structural Framework for the Polymodal Pain Sensor TRPV1 Biophysical Journal. 106: 756a. DOI: 10.1016/J.Bpj.2013.11.4162  0.471
2014 Zamanian M, Bae C, Tilley D, Gupta K, Sack J, Yarov-Yarovoy V, Kim JI, Swartz K. Common Interaction Surfaces for Tarantula Toxins Targeting Kv and ASIC Channels Biophysical Journal. 106: 737-738. DOI: 10.1016/J.Bpj.2013.11.4065  0.534
2014 Tilley DC, Kaakati R, Yarov-Yarovoy V, Sack JT. Rosetta Structural Modeling of Tarantula Toxin Binding to Voltage Sensors Biophysical Journal. 106: 737a. DOI: 10.1016/J.Bpj.2013.11.4064  0.457
2014 Yarov-Yarovoy V, Wulff H. Structural Modeling of KCa3.1 Channel Interaction with Small Molecules Biophysical Journal. 106: 542a. DOI: 10.1016/J.Bpj.2013.11.3022  0.572
2014 Fomina A, Yarov-Yarovoy V. Structural Modeling of Hexameric and Tetrameric Ion Conduction Pathways of Orai1 Channel Biophysical Journal. 106: 3-4. DOI: 10.1016/J.Bpj.2013.11.1816  0.546
2013 Wulff H, Yarov-Yarovoy V. Channels: Sticking to nooks and crannies. Nature Chemical Biology. 9: 473-4. PMID 23868316 DOI: 10.1038/Nchembio.1292  0.539
2013 Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. First insights into structure-function relationships of alkylglycerol monooxygenase Pteridines. 24: 99-103. DOI: 10.1515/Pterid-2013-0007  0.331
2013 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of the Human Nav1.7 Sodium Channel Pore Biophysical Journal. 104: 137a. DOI: 10.1016/J.Bpj.2012.11.783  0.55
2013 Yuen GK, Mamikonian L, Li J, Yarov-Yarovoy V, Bossuyt J, Bers DM. The PLM Homotetramer has a Structural Basis that Parallels that of PLB: The Leucine Zipper Biophysical Journal. 104: 407a. DOI: 10.1016/J.Bpj.2012.11.2270  0.364
2013 Yang F, Yarov-Yarovoy V, Zheng J. Modeling Temperature-Dependent Ion Channel Protein Structural Changes with Rosetta Biophysical Journal. 104: 229a-230a. DOI: 10.1016/J.Bpj.2012.11.1295  0.449
2013 Tilley DC, Eum KS, Cohen BE, Yarov-Yarovoy V, Sack JT. Fluorescently Labeled Tarantula Toxin Reveals Voltage Dependent Adhesion to K+ Channels Biophysical Journal. 104: 197a. DOI: 10.1016/J.Bpj.2012.11.1111  0.565
2012 Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM. Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proceedings of the National Academy of Sciences of the United States of America. 109: 20756-61. PMID 23185013 DOI: 10.1073/Pnas.1207866109  0.305
2012 Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B. An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. The Journal of General Physiology. 140: 587-94. PMID 23183694 DOI: 10.1085/Jgp.201210873  0.493
2012 Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels. The Journal of Biological Chemistry. 287: 30719-28. PMID 22761417 DOI: 10.1074/Jbc.M112.370742  0.515
2012 Cui Y, Yang F, Cao X, Yarov-Yarovoy V, Wang K, Zheng J. Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. The Journal of General Physiology. 139: 273-83. PMID 22412190 DOI: 10.1085/Jgp.201110724  0.434
2012 Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. The Biochemical Journal. 443: 279-86. PMID 22220568 DOI: 10.1042/Bj20111509  0.332
2012 Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA. Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 109: E93-102. PMID 22160714 DOI: 10.1073/Pnas.1118434109  0.575
2012 Yarov-Yarovoy V. Structural Modeling of a Human Voltage-Gated Sodium Channel Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3286  0.569
2012 Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. Mapping the Receptor Sites for a β-Scorpion Toxin on the Pore Module in Domain III of Voltage-Gated Sodium Channels Biophysical Journal. 102: 325a. DOI: 10.1016/J.Bpj.2011.11.1782  0.548
2011 DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 108: 18825-30. PMID 22042870 DOI: 10.1073/Pnas.1116449108  0.478
2011 Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA. Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 108: 15426-31. PMID 21876146 DOI: 10.1073/Pnas.1112320108  0.482
2011 Kisiela DI, Kramer JJ, Tchesnokova V, Aprikian P, Yarov-Yarovoy V, Clegg S, Sokurenko EV. Allosteric catch bond properties of the FimH adhesin from Salmonella enterica serovar Typhimurium. The Journal of Biological Chemistry. 286: 38136-47. PMID 21795699 DOI: 10.1074/Jbc.M111.237511  0.332
2011 Zhang JZ, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, Gurevitz M, Catterall WA. Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels. The Journal of Biological Chemistry. 286: 33641-51. PMID 21795675 DOI: 10.1074/Jbc.M111.282509  0.512
2011 DeCaen PG, Yarov-Yarovoy V, Scheuer T, Catterall WA. Disulfide Locking Reveals Interaction of the Gating Charges with a Negative Charge in the S1 Segment During Activation of the NaChBac Voltage Sensor Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2500  0.464
2011 Yarov-Yarovoy VM, DeCaen P, Scheuer T, Baker D, Catterall WA. High-Resolution Structural Modeling of Voltage-Dependent Conformational Changes in the Voltage Sensor of NaChBac Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2499  0.491
2011 Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, Catterall WA. Molecular Determinants for Alpha-Scorpion Toxin Binding to the Resting State of a Voltage Sensor of Brain Sodium Channels Biophysical Journal. 100: 422a. DOI: 10.1016/J.Bpj.2010.12.2498  0.541
2010 Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY. Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins. 78: 2922-34. PMID 20740484 DOI: 10.1002/Prot.22815  0.572
2010 Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K. Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophysical Journal. 98: 2189-98. PMID 20483327 DOI: 10.1016/J.Bpj.2010.02.056  0.512
2010 Catterall WA, Yarov-Yarovoy V. Helical motion of an S4 voltage sensor revealed by gating pore currents. Channels (Austin, Tex.). 4: 75-7. PMID 20139706 DOI: 10.4161/Chan.4.2.10998  0.496
2010 Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K. Refinement and Validation of Atomic Models of the Kv1.2 Potassium Channel Through Molecular Dynamics and Gating Charge Calculations Biophysical Journal. 98: 520a-521a. DOI: 10.1016/J.Bpj.2009.12.2830  0.526
2009 DeCaen PG, Yarov-Yarovoy V, Sharp EM, Scheuer T, Catterall WA. Sequential formation of ion pairs during activation of a sodium channel voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 106: 22498-503. PMID 20007787 DOI: 10.1073/Pnas.0912307106  0.459
2009 Lees-Miller JP, Subbotina JO, Guo J, Yarov-Yarovoy V, Noskov SY, Duff HJ. Interactions of H562 in the S5 helix with T618 and S621 in the pore helix are important determinants of hERG1 potassium channel structure and function. Biophysical Journal. 96: 3600-10. PMID 19413965 DOI: 10.1016/J.Bpj.2009.01.028  0.465
2009 Khalili-Araghi F, Jogini V, Yarov-Yarovoy V, Tajkhorshid E, Roux B, Schulten K. Molecular Dynamics Simulation of the Kv1.2 Potassium Channel Biophysical Journal. 96: 191a-192a. DOI: 10.1016/J.Bpj.2008.12.899  0.528
2009 Yarov-Yarovoy VM, DeCaen P, Scheuer T, Catterall WA. Structural Modeling of Intermediate States of the Gating Pore of NaChBac Biophysical Journal. 96: 253a. DOI: 10.1016/J.Bpj.2008.12.1250  0.427
2008 DeCaen PG, Yarov-Yarovoy V, Zhao Y, Scheuer T, Catterall WA. Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15142-7. PMID 18809926 DOI: 10.1073/Pnas.0806486105  0.533
2007 Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. Closing in on the resting state of the Shaker K(+) channel. Neuron. 56: 124-40. PMID 17920020 DOI: 10.1016/J.Neuron.2007.09.023  0.55
2007 Catterall WA, Cestèle S, Yarov-Yarovoy V, Yu FH, Konoki K, Scheuer T. Voltage-gated ion channels and gating modifier toxins. Toxicon : Official Journal of the International Society On Toxinology. 49: 124-41. PMID 17239913 DOI: 10.1016/J.Toxicon.2006.09.022  0.575
2006 Hulme JT, Yarov-Yarovoy V, Lin TW, Scheuer T, Catterall WA. Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domain. The Journal of Physiology. 576: 87-102. PMID 16809371 DOI: 10.1113/jphysiol.2006.111799  0.399
2006 Cestèle S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, Catterall WA. Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. The Journal of Biological Chemistry. 281: 21332-44. PMID 16679310 DOI: 10.1074/Jbc.M603814200  0.473
2006 Yarov-Yarovoy V, Baker D, Catterall WA. Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proceedings of the National Academy of Sciences of the United States of America. 103: 7292-7. PMID 16648251 DOI: 10.1073/Pnas.0602350103  0.603
2006 Yarov-Yarovoy V, Schonbrun J, Baker D. Multipass membrane protein structure prediction using Rosetta. Proteins. 62: 1010-25. PMID 16372357 DOI: 10.1002/Prot.20817  0.414
2005 Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacological Reviews. 57: 387-95. PMID 16382097 DOI: 10.1124/Pr.57.4.13  0.4
2004 Zhao Y, Yarov-Yarovoy V, Scheuer T, Catterall WA. A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron. 41: 859-65. PMID 15046719 DOI: 10.1016/S0896-6273(04)00116-3  0.556
2003 Liu G, Yarov-Yarovoy V, Nobbs M, Clare JJ, Scheuer T, Catterall WA. Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels. Neuropharmacology. 44: 413-22. PMID 12604088 DOI: 10.1016/S0028-3908(02)00400-8  0.471
2002 Yarov-Yarovoy V, McPhee JC, Idsvoog D, Pate C, Scheuer T, Catterall WA. Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. The Journal of Biological Chemistry. 277: 35393-401. PMID 12130650 DOI: 10.1074/Jbc.M206126200  0.446
2001 Yarov-Yarovoy V, Brown J, Sharp EM, Clare JJ, Scheuer T, Catterall WA. Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit. The Journal of Biological Chemistry. 276: 20-7. PMID 11024055 DOI: 10.1074/Jbc.M006992200  0.489
1998 Jabůrek M, Yarov-Yarovoy V, Paucek P, Garlid KD. State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate Journal of Biological Chemistry. 273: 13578-13582. DOI: 10.1074/Jbc.273.22.13578  0.437
1997 Yarov-Yarovoy V, Paucek P, Jabůrek M, Garlid KD. The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol Biochimica Et Biophysica Acta. 1321: 128-136. PMID 9332501 DOI: 10.1016/S0005-2728(97)00051-0  0.382
1996 Paucek P, Yarov-Yarovoy V, Sun X, Garlid KD. Inhibition of the Mitochondrial KATP Channel by Long-chain Acyl-CoA Esters and Activation by Guanine Nucleotides Journal of Biological Chemistry. 271: 32084-32088. PMID 8943260 DOI: 10.1074/Jbc.271.50.32084  0.375
1996 Garlid KD, Paucek P, Yarov-Yarovoy V, Sun X, Schindler PA. The mitochondrial KATP channel as a receptor for potassium channel openers. The Journal of Biological Chemistry. 271: 8796-9. PMID 8621517 DOI: 10.1074/Jbc.271.15.8796  0.479
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