Year |
Citation |
Score |
2020 |
Walvekar AS, Kadamur G, Sreedharan S, Gupta R, Srinivasan R, Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. The Journal of Biological Chemistry. 295: 18390-18405. PMID 33453842 DOI: 10.1074/jbc.RA120.014248 |
0.325 |
|
2020 |
Srinivasan R, Walvekar AS, Rashida Z, Seshasayee A, Laxman S. Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program. Plos Genetics. 16: e1009252. PMID 33378328 DOI: 10.1371/journal.pgen.1009252 |
0.308 |
|
2020 |
Walvekar AS, Kadamur G, Sreedharan S, Gupta R, Srinivasan R, Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. The Journal of Biological Chemistry. PMID 33122193 DOI: 10.1074/jbc.RA120.014248 |
0.328 |
|
2020 |
Bhatia M, Thakur J, Suyal S, Oniel R, Chakraborty R, Pradhan S, Sharma M, Sengupta S, Laxman S, Masakapalli SK, Bachhawat AK. Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism. The Journal of Biological Chemistry. PMID 32934008 DOI: 10.1074/Jbc.Ra120.015129 |
0.421 |
|
2020 |
Varahan S, Sinha V, Walvekar A, Krishna S, Laxman S. Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community. Elife. 9. PMID 32876564 DOI: 10.7554/Elife.57609 |
0.335 |
|
2020 |
Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. The Rad53-Spt21 and Tel1 axes couple glucose tolerance to histone dosage and subtelomeric silencing. Nature Communications. 11: 4154. PMID 32814778 DOI: 10.1038/S41467-020-17961-4 |
0.327 |
|
2019 |
Walvekar AS, Laxman S. Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast. Frontiers in Microbiology. 10: 2624. PMID 31798560 DOI: 10.3389/Fmicb.2019.02624 |
0.415 |
|
2019 |
Gupta R, Laxman S. tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state. Current Genetics. PMID 31758251 DOI: 10.1007/S00294-019-01045-Y |
0.433 |
|
2019 |
Shaw E, Talwadekar M, Rashida Z, Mohan N, Acharya A, Khatri S, Laxman S, Kolthur-Seetharam U. Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria. Molecular and Cellular Biology. PMID 31685549 DOI: 10.1128/Mcb.00212-19 |
0.358 |
|
2019 |
Vengayil V, Rashida Z, Laxman S. The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability. The Journal of Biological Chemistry. PMID 31604822 DOI: 10.1074/Jbc.Ra119.009822 |
0.32 |
|
2019 |
Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. Elife. 8. PMID 31259691 DOI: 10.7554/Elife.44795 |
0.429 |
|
2019 |
Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S. Metabolic constraints drive self-organization of specialized cell groups. Elife. 8. PMID 31241462 DOI: 10.7554/Elife.46735 |
0.337 |
|
2019 |
Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S. Author response: Metabolic constraints drive self-organization of specialized cell groups Elife. DOI: 10.7554/Elife.46735.033 |
0.302 |
|
2019 |
Gupta R, Walvekar AS, Liang S, Rashida Z, Shah P, Laxman S. Author response: A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis Elife. DOI: 10.7554/Elife.44795.031 |
0.362 |
|
2018 |
Walvekar AS, Srinivasan R, Gupta R, Laxman S. Methionine coordinates a hierarchically organized anabolic program enabling proliferation. Molecular Biology of the Cell. mbcE18080515. PMID 30354837 DOI: 10.1091/Mbc.E18-08-0515 |
0.397 |
|
2018 |
Krishna S, Laxman S. A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states. Molecular Biology of the Cell. mbcE18010017. PMID 30044724 DOI: 10.1091/Mbc.E18-01-0017 |
0.345 |
|
2017 |
Laxman S. Conceptualizing Eukaryotic Metabolic Sensing and Signaling. Journal of the Indian Institute of Science. 97: 59-77. PMID 29176927 DOI: 10.1007/S41745-016-0013-1 |
0.41 |
|
2017 |
Deshpande AA, Bhatia M, Laxman S, Bachhawat AK. Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload. Microbial Cell (Graz, Austria). 4: 112-126. PMID 28435838 DOI: 10.15698/Mic2017.04.567 |
0.401 |
|
2016 |
Erkut C, Gade VR, Laxman S, Kurzchalia TV. The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast. Elife. 5. PMID 27090086 DOI: 10.7554/Elife.13614 |
0.339 |
|
2016 |
Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu B, MacMillan JB, De Brabander JK, Veech RL, Uyeda K. Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor. The Journal of Biological Chemistry. PMID 26984404 DOI: 10.1074/Jbc.M115.708982 |
0.606 |
|
2015 |
Dhawan J, Laxman S. Decoding the stem cell quiescence cycle - lessons from yeast for regenerative biology. Journal of Cell Science. 128: 4467-74. PMID 26672015 DOI: 10.1242/Jcs.177758 |
0.338 |
|
2015 |
Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Reports. 12: 371-9. PMID 26166573 DOI: 10.1016/J.Celrep.2015.06.042 |
0.624 |
|
2014 |
Laxman S, Sutter BM, Shi L, Tu BP. Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites. Science Signaling. 7: ra120. PMID 25515537 DOI: 10.1126/Scisignal.2005948 |
0.654 |
|
2014 |
Laxman S, Tu BP, McKnight SL. Concerted effort: oscillations in global gene expression during nematode development. Molecular Cell. 53: 363-4. PMID 24507713 DOI: 10.1016/J.Molcel.2014.01.023 |
0.636 |
|
2014 |
Laxman S, Sutter BM, Tu BP. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A. Autophagy. 10: 386-7. PMID 24362312 DOI: 10.4161/Auto.27485 |
0.651 |
|
2013 |
Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP. Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell. 154: 416-29. PMID 23870129 DOI: 10.1016/J.Cell.2013.06.043 |
0.649 |
|
2013 |
Sutter BM, Wu X, Laxman S, Tu BP. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell. 154: 403-15. PMID 23870128 DOI: 10.1016/J.Cell.2013.06.041 |
0.623 |
|
2013 |
Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, et al. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Proceedings of the National Academy of Sciences of the United States of America. 110: 9728-33. PMID 23716694 DOI: 10.1073/Pnas.1303220110 |
0.597 |
|
2011 |
Laxman S, Tu BP. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. Plos One. 6: e26081. PMID 22043304 DOI: 10.1371/Journal.Pone.0026081 |
0.626 |
|
2011 |
Narula A, Laxman S, Beavo JA. Phosphodiesterase 10 Xpharm: the Comprehensive Pharmacology Reference. 1-11. DOI: 10.1016/B978-008055232-3.60551-3 |
0.432 |
|
2010 |
Laxman S, Tu BP. Systems approaches for the study of metabolic cycles in yeast. Current Opinion in Genetics & Development. 20: 599-604. PMID 21051220 DOI: 10.1016/J.Gde.2010.09.008 |
0.611 |
|
2010 |
Laxman S, Sutter BM, Tu BP. Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters. Plos One. 5: e12595. PMID 20830298 DOI: 10.1371/Journal.Pone.0012595 |
0.612 |
|
2007 |
Laxman S, Beavo JA. Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents. Molecular Interventions. 7: 203-15. PMID 17827441 DOI: 10.1124/Mi.7.4.7 |
0.532 |
|
2006 |
Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proceedings of the National Academy of Sciences of the United States of America. 103: 19194-9. PMID 17142316 DOI: 10.1073/Pnas.0608971103 |
0.5 |
|
2006 |
Díaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascón A. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. The Biochemical Journal. 399: 305-14. PMID 16776650 DOI: 10.1042/Bj20060757 |
0.527 |
|
2006 |
Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature. Molecular and Biochemical Parasitology. 145: 133-5. PMID 16280178 DOI: 10.1016/J.Molbiopara.2005.09.018 |
0.499 |
|
2005 |
Laxman S, Rascón A, Beavo JA. Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain. The Journal of Biological Chemistry. 280: 3771-9. PMID 15563461 DOI: 10.1074/Jbc.M408111200 |
0.515 |
|
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