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Kevin J. Sampson, Ph.D. - Publications

Affiliations: 
2004 Duke University, Durham, NC 
Area:
Biomedical Engineering, Neuroscience Biology, General Biophysics, Medical Biophysics
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zou X, Shanmugam SK, Kanner SA, Sampson KJ, Kass RS, Colecraft HM. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex. Elife. 12. PMID 37650513 DOI: 10.7554/eLife.83466  0.338
2022 Zou X, Wu X, Sampson KJ, Colecraft HM, Larsson HP, Kass RS. Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. Frontiers in Physiology. 13: 902224. PMID 36505078 DOI: 10.3389/fphys.2022.902224  0.375
2022 Redel-Traub G, Sampson KJ, Kass RS, Bohnen MS. Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension. Biomolecules. 12. PMID 36291551 DOI: 10.3390/biom12101341  0.304
2022 Chen L, Peng G, Comollo TW, Zou X, Sampson KJ, Larsson HP, Kass RS. Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements. Frontiers in Physiology. 13: 903050. PMID 35957984 DOI: 10.3389/fphys.2022.903050  0.388
2022 Comollo TW, Zou X, Zhang C, Kesters D, Hof T, Sampson KJ, Kass RS. Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers. Channels (Austin, Tex.). 16: 173-184. PMID 35949058 DOI: 10.1080/19336950.2022.2106025  0.416
2021 Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan WL, Sampson KJ, Kass RS, Mercola M, Cashman JR. Human iPSC-derived Cardiomyocytes and Pyridyl-Phenyl Mexiletine Analogs. Bioorganic & Medicinal Chemistry Letters. 128162. PMID 34062251 DOI: 10.1016/j.bmcl.2021.128162  0.336
2021 Cashman JR, Ryan D, McKeithan WL, Okolotowicz K, Gomez-Galeno J, Johnson M, Sampson KJ, Kass RS, Pezhouman A, Karagueuzian HS, Mercola M. Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes. Journal of Medicinal Chemistry. PMID 33942619 DOI: 10.1021/acs.jmedchem.0c01545  0.377
2020 McKeithan WL, Feyen DAM, Bruyneel AAN, Okolotowicz KJ, Ryan DA, Sampson KJ, Potet F, Savchenko A, Gómez-Galeno J, Vu M, Serrano R, George AL, Kass RS, Cashman JR, Mercola M. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity. Cell Stem Cell. PMID 32931730 DOI: 10.1016/J.Stem.2020.08.003  0.423
2019 Wu X, Perez ME, Sampson KJ, Kass RS, Larsson PH. Determining Functional KCNQ1/KCNE1 Subunit Interactions in the KCNQ1/KCNE1 Channel Biophysical Journal. 116: 539a. DOI: 10.1016/J.Bpj.2018.11.2900  0.435
2017 Bohnen MS, Roman-Campos D, Terrenoire C, Jnani J, Sampson KJ, Chung WK, Kass RS. The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery. Journal of the American Heart Association. 6. PMID 28889099 DOI: 10.1161/Jaha.117.006465  0.377
2017 Osteen JD, Sampson K, Iyer V, Julius D, Bosmans F. Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28607094 DOI: 10.1073/Pnas.1621263114  0.477
2017 Peng G, Barro-Soria R, Sampson KJ, Larsson HP, Kass RS. Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations. Scientific Reports. 7: 45911. PMID 28383569 DOI: 10.1038/Srep45911  0.506
2017 Bohnen MS, Peng G, Robey SH, Terrenoire C, Iyer V, Sampson KJ, Kass RS. Molecular Pathophysiology of Congenital Long QT Syndrome. Physiological Reviews. 97: 89-134. PMID 27807201 DOI: 10.1152/Physrev.00008.2016  0.497
2016 Chen L, Sampson KJ, Kass RS. Cardiac Delayed Rectifier Potassium Channels in Health and Disease. Cardiac Electrophysiology Clinics. 8: 307-22. PMID 27261823 DOI: 10.1016/J.Ccep.2016.01.004  0.513
2016 Lorberbaum T, Sampson KJ, Woosley RL, Kass RS, Tatonetti NP. An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval. Drug Safety. PMID 26860921 DOI: 10.1007/S40264-016-0393-1  0.321
2015 Iyer V, Roman-Campos D, Sampson KJ, Kang G, Fishman GI, Kass RS. Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3. Scientific Reports. 5: 13287. PMID 26289036 DOI: 10.1038/Srep13287  0.396
2015 Bohnen MS, Iyer V, Sampson KJ, Kass RS. Novel mechanism of transient outward potassium channel current regulation in the heart: implications for cardiac electrophysiology in health and disease. Circulation Research. 116: 1633-5. PMID 25953919 DOI: 10.1161/Circresaha.115.306438  0.488
2015 Robey SH, Sampson KJ, Kass RS. Single-Channel Analysis of the Molecular Pharmacology of the Long QT Syndrome Variant 3 Biophysical Journal. 108: 584a-585a. DOI: 10.1016/J.Bpj.2014.11.3190  0.562
2015 Peng G, Sampson KJ, Barro-Soria R, Larsson HP, Kass RS. Two KCNQ1 Mutations Associated with Familial Atrial Fibrillation, S140G and V141M, Demonstrate Distinct Voltage Sensor Phenotypes Biophysical Journal. 108: 427a. DOI: 10.1016/J.Bpj.2014.11.2335  0.472
2015 Barro-Soria R, Peng G, Sampson KJ, Kass RS, Larsson HP. KCNE3 Stabilizes the Voltage Sensor S4 of KCNQ1 Channel, KCNE1 Uncouples S4 and the Gate Biophysical Journal. 108: 276a. DOI: 10.1016/J.Bpj.2014.11.1511  0.525
2014 Iyer V, Sampson KJ, Kass RS. Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber. Plos One. 9: e97720. PMID 24892747 DOI: 10.1371/Journal.Pone.0097720  0.447
2014 Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP. KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps. Nature Communications. 5: 3750. PMID 24769622 DOI: 10.1038/Ncomms4750  0.495
2014 Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson K, Kass RS, Larsson HP. KCNE1 Separates the Main Voltage Sensor Movement and Channel Opening in KCNQ1/KCNE1 Channels Biophysical Journal. 106: 142a. DOI: 10.1016/J.Bpj.2013.11.825  0.509
2013 Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, et al. Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Circulation Research. 112: 1310-22. PMID 23532596 DOI: 10.1161/Circresaha.112.300227  0.469
2013 Terrenoire C, Wang K, Tung KW, Chung WK, Pass RH, Lu JT, Jean JC, Omari A, Sampson KJ, Kotton DN, Keller G, Kass RS. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. The Journal of General Physiology. 141: 61-72. PMID 23277474 DOI: 10.1083/Jcb2001Oia3  0.492
2013 Barro-Soria R, Osteen JD, Sampson KJ, Perez ME, Kass RS, Larsson HP. Long QT Mutations and KCNE1 β-Subunit Modulate S4 Movement in KCNQ1 Channel Biophysical Journal. 104: 357a. DOI: 10.1016/J.Bpj.2012.11.1982  0.525
2012 Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP. Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 7103-8. PMID 22509038 DOI: 10.1073/Pnas.1201582109  0.458
2012 Glaaser IW, Osteen JD, Puckerin A, Sampson KJ, Jin X, Kass RS. Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation. Nature Communications. 3: 706. PMID 22426227 DOI: 10.1038/Ncomms1717  0.492
2012 Chan PJ, Osteen JD, Xiong D, Bohnen MS, Doshi D, Sampson KJ, Marx SO, Karlin A, Kass RS. Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1. The Journal of General Physiology. 139: 135-44. PMID 22250012 DOI: 10.1085/Jgp.201110672  0.518
2012 Iyer V, Sampson K, Kass R. Computational Predictions of Tissue-Specific Consequences of Long QT Mutations: Role of the Purkinje Fiber Biophysical Journal. 102: 543a. DOI: 10.1016/J.Bpj.2011.11.2963  0.509
2012 Wang K, Terrenoire C, Sampson KJ, Lyer V, Chan Tung KW, Lu J, Chung W, Pass RH, Keller G, Kotton DN, Kass RS. Patient-Specific Inducible Pluripotent Stem Cells Reveal Mechanism of Personalized Therapy for an Inherited Cardiac Arrhythmia Biophysical Journal. 102: 539a. DOI: 10.1016/J.Bpj.2011.11.2947  0.45
2012 Osteen JD, Robey SH, Barro R, Rebolledo S, Sampson KJ, Larsson HP, Kass RS. Allosteric Properties of KCNQ1 (Kv7.1) Channel Gating Detected by Voltage Clamp Fluorometry Biophysical Journal. 102: 332a. DOI: 10.1016/J.Bpj.2011.11.1819  0.465
2012 Barro-Soria R, Osteen JD, Sampson KJ, Perez ME, Kass RS, Larsson P. Activation of Voltage Sensing Domains during KCNQ1 Channel Opening: Concerted or Independent? Biophysical Journal. 102: 332a. DOI: 10.1016/J.Bpj.2011.11.1817  0.547
2011 Wang K, Terrenoire C, Sampson KJ, Iyer V, Osteen JD, Lu J, Keller G, Kotton DN, Kass RS. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. The Journal of Physiology. 589: 6093-104. PMID 22025662 DOI: 10.1113/Jphysiol.2011.220863  0.51
2011 Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS. A novel Beta Subunit Mechanism in a Critical Heart K Channel: KCNE1 Alters the Voltage Sensor Movements Necessary to Open the KCNQ1 Channel Gate Biophysical Journal. 100: 29a-30a. DOI: 10.1016/J.Bpj.2010.12.365  0.498
2011 Wang K, Terrenoire C, Sampson KJ, Osteen JD, Lu J, Gagliardi M, Keller G, Kass RS. Biophysical Characterization of Iks Channels in Cardiomyocytes Derived from Human Embryonic Stem Cells Reveals Insights Into Stoichiometry of KCNQ1-KCNE1 Complex Biophysical Journal. 100: 439a. DOI: 10.1016/J.Bpj.2010.12.2588  0.466
2010 Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate. Proceedings of the National Academy of Sciences of the United States of America. 107: 22710-5. PMID 21149716 DOI: 10.1073/Pnas.1016300108  0.504
2010 Osteen JD, Sampson KJ, Kass RS. The cardiac IKs channel, complex indeed. Proceedings of the National Academy of Sciences of the United States of America. 107: 18751-2. PMID 20974964 DOI: 10.1073/Pnas.1014150107  0.517
2010 Sampson KJ, Kass RS. Location, location, regulation: a novel role for β-spectrin in the heart. The Journal of Clinical Investigation. 120: 3434-7. PMID 20877007 DOI: 10.1172/Jci44810  0.495
2010 Sampson KJ, Iyer V, Marks AR, Kass RS. A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome. The Journal of Physiology. 588: 2643-55. PMID 20498233 DOI: 10.1113/Jphysiol.2010.187328  0.513
2010 Sampson KJ, Kass RS. Molecular mechanisms of adrenergic stimulation in the heart. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 7: 1151-3. PMID 20156590 DOI: 10.1016/J.Hrthm.2010.02.013  0.424
2010 Terrenoire C, Wang GK, Adler E, Kaplan AD, Sampson K, Lu J, Kass RS. KCNQ1/KCNE1 K+ Channels Associated with Long QT Syndrome are Expressed in Early Stage Human Embryonic Stem Cell-Derived Cardiomyocytes Biophysical Journal. 98: 335a. DOI: 10.1016/J.Bpj.2009.12.1817  0.528
2008 Sampson KJ, Terrenoire C, Cervantes DO, Kaba RA, Peters NS, Kass RS. Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an I Ks transgenic mouse. The Journal of Physiology. 586: 627-37. PMID 18006587 DOI: 10.1113/Jphysiol.2007.141333  0.471
2007 Bankston JR, Sampson KJ, Kateriya S, Glaaser IW, Malito DL, Chung WK, Kass RS. A novel LQT-3 mutation disrupts an inactivation gate complex with distinct rate-dependent phenotypic consequences. Channels (Austin, Tex.). 1: 273-80. PMID 18708744 DOI: 10.4161/Chan.4956  0.526
2007 Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS. Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 20990-5. PMID 18093912 DOI: 10.1073/Pnas.0710527105  0.487
2007 Bankston JR, Yue M, Chung W, Spyres M, Pass RH, Silver E, Sampson KJ, Kass RS. A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. Plos One. 2: e1258. PMID 18060054 DOI: 10.1371/Journal.Pone.0001258  0.494
2006 Fredj S, Lindegger N, Sampson KJ, Carmeliet P, Kass RS. Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes. Circulation Research. 99: 1225-32. PMID 17082480 DOI: 10.1161/01.Res.0000251305.25604.B0  0.473
2006 Fredj S, Sampson KJ, Liu H, Kass RS. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. British Journal of Pharmacology. 148: 16-24. PMID 16520744 DOI: 10.1038/Sj.Bjp.0706709  0.539
2005 Sampson KJ, Henriquez CS. Electrotonic influences on action potential duration dispersion in small hearts: a simulation study. American Journal of Physiology. Heart and Circulatory Physiology. 289: H350-60. PMID 15734889 DOI: 10.1152/Ajpheart.00507.2004  0.605
2005 Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circulation Research. 96: e25-34. PMID 15731462 DOI: 10.1161/01.Res.0000160555.58046.9A  0.468
2004 Shao H, Sampson KJ, Pormann JB, Rose DJ, Henriquez CS. A resistor interpretation of general anisotropic cardiac tissue. Mathematical Biosciences. 187: 155-74. PMID 14739082 DOI: 10.1016/J.Mbs.2003.10.005  0.551
2002 Sampson KJ, Henriquez CS. Interplay of ionic and structural heterogeneity on functional action potential duration gradients: Implications for arrhythmogenesis. Chaos (Woodbury, N.Y.). 12: 819-828. PMID 12779610 DOI: 10.1063/1.1497735  0.603
2001 Sampson KJ, Henriquez CS. Simulation and prediction of functional block in the presence of structural and ionic heterogeneity. American Journal of Physiology. Heart and Circulatory Physiology. 281: H2597-603. PMID 11709428 DOI: 10.1152/Ajpheart.2001.281.6.H2597  0.593
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