Whasil Lee, Ph.D.

Affiliations: 
2018- Biomedical Engineering / Pharmacology and Physiology University of Rochester, Rochester, NY 
Area:
Mechanotransduction, Cell mechanics
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"Whasil Lee"

Parents

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Tony F. Heinz grad student 2003-2005 Columbia (Chemistry Tree)
Vann Bennett grad student 2006-2011 Duke (Chemistry Tree)
Piotr E. Marszalek grad student 2006-2011 Duke
Farshid Guilak post-doc 2011-2018 Duke Medical School (Biomechanics Tree)
Wolfgang Liedtke post-doc 2011-2018 Duke Medical School

Collaborators

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Jörg Grandl collaborator 2014- Duke (Neurotree)
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Publications

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Lee W, Nims RJ, Savadipour A, et al. (2021) Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118
Lee W, Guilak F, Liedtke W. (2017) Role of Piezo Channels in Joint Health and Injury. Current Topics in Membranes. 79: 263-273
Kanju P, Chen Y, Lee W, et al. (2016) Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Scientific Reports. 6: 26894
Lee W, Leddy HA, Chen Y, et al. (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22
Chen Y, Kanju P, Fang Q, et al. (2014) TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain. 155: 2662-72
Lee W, Strümpfer J, Bennett V, et al. (2012) Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats. The Journal of Biological Chemistry. 287: 19115-21
Lee W, Zeng X, Rotolo K, et al. (2012) Mechanical anisotropy of ankyrin repeats. Biophysical Journal. 102: 1118-26
Lee W, Strümpfer J, Bennett V, et al. (2012) Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats (Journal of Biological Chemistry (2012) 287, (19115-19121) DOI: 10.1074/jbc.A112.365569) Journal of Biological Chemistry. 287: 35539
Lee W, Zeng X, Zhou HX, et al. (2010) Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. The Journal of Biological Chemistry. 285: 38167-72
Kim M, Abdi K, Lee G, et al. (2010) Fast and forceful refolding of stretched alpha-helical solenoid proteins. Biophysical Journal. 98: 3086-92
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