Whasil Lee, Ph.D.
Affiliations: | 2018- | Biomedical Engineering / Pharmacology and Physiology | University of Rochester, Rochester, NY |
Area:
Mechanotransduction, Cell mechanicsGoogle:
"Whasil Lee"Parents
Sign in to add mentor| Tony F. Heinz | grad student | 2003-2005 | Columbia (Chemistry Tree) |
| Vann Bennett | grad student | 2006-2011 | Duke (Chemistry Tree) |
| Piotr E. Marszalek | grad student | 2006-2011 | Duke |
| Farshid Guilak | post-doc | 2011-2018 | Duke Medical School (Biomechanics Tree) |
| Wolfgang Liedtke | post-doc | 2011-2018 | Duke Medical School |
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Publications
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| Gao W, Hasan H, Anderson DE, et al. (2022) The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis. Frontiers in Cell and Developmental Biology. 10: 885224 |
| Lee W, Nims RJ, Savadipour A, et al. (2021) Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Lee W, Guilak F, Liedtke W. (2017) Role of Piezo Channels in Joint Health and Injury. Current Topics in Membranes. 79: 263-273 |
| Kanju P, Chen Y, Lee W, et al. (2016) Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Scientific Reports. 6: 26894 |
| Lee W, Leddy H, McNulty A, et al. (2016) Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression Biophysical Journal. 110: 349a |
| Lee W, Leddy HA, Chen Y, et al. (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22 |
| Chen Y, Kanju P, Fang Q, et al. (2014) TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain. 155: 2662-72 |
| Lee W, Leddy H, Guilak F, et al. (2014) Characterization of Mechanotransensitivity of Articular Chondrocytes Biophysical Journal. 106: 389a-390a |
| Lee W, Strümpfer J, Bennett V, et al. (2012) Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats. The Journal of Biological Chemistry. 287: 19115-21 |
| Lee W, Zeng X, Rotolo K, et al. (2012) Mechanical anisotropy of ankyrin repeats. Biophysical Journal. 102: 1118-26 |