Shelly B. Flagel - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Behavioral Neuroscience, Addiction

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 King CP, Chitre AS, Leal-Gutiérrez JD, Tripi JA, Hughson AR, Horvath AP, Lamparelli AC, George A, Martin C, St Pierre CL, Bimschleger HV, Gao J, Cheng R, Nguyen KM, Holl KL, ... ... Flagel SB, et al. Genome-Wide Association Study in Outbred Heterogeneous Stock Rats Identifies Multiple Loci for the Incentive Salience of Reward Cues. Biorxiv : the Preprint Server For Biology. PMID 38559127 DOI: 10.1101/2024.03.13.584852  0.629
2023 Iglesias AG, Chiu AS, Wong J, Campus P, Li F, Liu ZN, Bhatti JK, Patel SA, Deisseroth K, Akil H, Burgess CR, Flagel SB. Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 37709540 DOI: 10.1523/JNEUROSCI.0848-23.2023  0.841
2023 Wright SN, Leger BS, Rosenthal SB, Liu SN, Jia T, Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Garcia Martinez A, George A, Gileta AF, Han W, Netzley AH, ... ... Flagel SB, et al. Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks. Cell Reports. 42: 112873. PMID 37527041 DOI: 10.1016/j.celrep.2023.112873  0.662
2023 Iglesias AG, Chiu AS, Wong J, Campus P, Li F, Liu ZN, Patel SA, Deisseroth K, Akil H, Burgess CR, Flagel SB. Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping. Biorxiv : the Preprint Server For Biology. PMID 37205506 DOI: 10.1101/2023.05.03.539324  0.846
2023 Chitre AS, Polesskaya O, Munro D, Cheng R, Mohammadi P, Holl K, Gao J, Bimschleger H, Martinez AG, George A, Gileta AF, Horvath A, Hughson A, Ishiwari K, King CP, ... ... Flagel SB, et al. Exponential increase in QTL detection with increased sample size. Genetics. PMID 36974931 DOI: 10.1093/genetics/iyad054  0.664
2023 Colaizzi JM, Flagel SB, Gearhardt AN, Borowitz MA, Kuplicki R, Zotev V, Clark G, Coronado J, Abbott T, Paulus MP. The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth. Scientific Reports. 13: 4402. PMID 36928057 DOI: 10.1038/s41598-023-30906-3  0.389
2023 Chitre AS, Hebda-Bauer EK, Blandino P, Bimschleger H, Nguyen KM, Maras P, Li F, Ozel AB, Pan Y, Polesskaya O, Cheng R, Flagel SB, Watson SJ, Li J, Akil H, et al. Genome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traits. Frontiers in Genetics. 13: 1003074. PMID 36712851 DOI: 10.3389/fgene.2022.1003074  0.468
2022 Parsegian A, García-Fuster MJ, Hebda-Bauer E, Watson SJ, Flagel SB, Akil H. Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes. Frontiers in Psychiatry. 13: 1024617. PMID 36311521 DOI: 10.3389/fpsyt.2022.1024617  0.516
2022 Gileta AF, Fitzpatrick CJ, Chitre AS, St Pierre CL, Joyce EV, Maguire RJ, McLeod AM, Gonzales NM, Williams AE, Morrow JD, Robinson TE, Flagel SB, Palmer AA. Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies. Plos Genetics. 18: e1010234. PMID 35639796 DOI: 10.1371/journal.pgen.1010234  0.543
2021 Flagel SB, Robinson TE, Sarter M. Comment on Pohorala et al.: Sign-tracking as a predictor of addiction vulnerability. Psychopharmacology. PMID 34308488 DOI: 10.1007/s00213-021-05927-3  0.401
2021 Kuhn BN, Campus P, Klumpner MS, Chang SE, Iglesias AG, Flagel SB. Correction to: Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats. Psychopharmacology. PMID 34286346 DOI: 10.1007/s00213-021-05919-3  0.816
2021 Iglesias AG, Flagel SB. The Paraventricular Thalamus as a Critical Node of Motivated Behavior the Hypothalamic-Thalamic-Striatal Circuit. Frontiers in Integrative Neuroscience. 15: 706713. PMID 34220458 DOI: 10.3389/fnint.2021.706713  0.357
2021 Kuhn BN, Campus P, Klumpner MS, Chang SE, Iglesias AG, Flagel SB. Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats. Psychopharmacology. PMID 34181035 DOI: 10.1007/s00213-021-05894-9  0.843
2021 Krueger LD, Chang SE, Motoc M, Chojecki M, Freeman ZT, Flagel SB. Effects of Pair Housing on Patency of Jugular Catheters in Rats (Rattus norvegicus). Journal of the American Association For Laboratory Animal Science : Jaalas. PMID 33863401 DOI: 10.30802/AALAS-JAALAS-20-000071  0.324
2021 Lopez SA, Mubarak E, Yang C, Parsegian A, Klumpner M, Campus P, Flagel SB. Male goal-tracker and sign-tracker rats do not differ in neuroendocrine or behavioral measures of stress-reactivity. Eneuro. PMID 33731330 DOI: 10.1523/ENEURO.0384-20.2021  0.814
2021 King CP, Tripi JA, Hughson AR, Horvath AP, Lamparelli AC, Holl KL, Chitre AS, Polesskaya O, Ishiwari K, Solberg Woods LC, Palmer AA, Robinson TE, Flagel SB, Meyer PJ. Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. Scientific Reports. 11: 2223. PMID 33500444 DOI: 10.1038/s41598-020-80798-w  0.787
2020 Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Bimschleger H, Garcia Martinez A, George T, Gileta AF, Han W, Horvath A, Hughson A, Ishiwari K, King CP, Lamparelli A, ... ... Flagel SB, et al. Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose. Obesity (Silver Spring, Md.). PMID 32860487 DOI: 10.1002/Oby.22927  0.7
2020 Haight JL, Campus P, Maria-Rios CE, Johnson AM, Klumpner MS, Kuhn BN, Covelo IR, Morrow JD, Flagel SB. The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues. Psychopharmacology. PMID 32852601 DOI: 10.1007/S00213-020-05651-4  0.797
2020 Lopez SA, Flagel SB. A proposed role for glucocorticoids in mediating dopamine-dependent cue-reward learning. Stress (Amsterdam, Netherlands). 1-41. PMID 32396486 DOI: 10.1080/10253890.2020.1768240  0.48
2020 Colaizzi JM, Flagel SB, Joyner MA, Gearhardt AN, Stewart JL, Paulus MP. Mapping sign-tracking and goal-tracking onto human behaviors. Neuroscience and Biobehavioral Reviews. 111: 84-94. PMID 31972203 DOI: 10.1016/J.Neubiorev.2020.01.018  0.431
2020 Flagel S, Lopez S, Kennedy R. Individual Differences in Cue-Reward Learning are Mediated by “Stress” Hormones in a Sex-Dependent Manner Biological Psychiatry. 87: S62. DOI: 10.1016/J.Biopsych.2020.02.181  0.446
2019 Campus P, Covelo IR, Kim Y, Parsegian A, Kuhn BN, Lopez SA, Neumaier JF, Ferguson SM, Solberg Woods LC, Sarter M, Flagel SB. The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats. Elife. 8. PMID 31502538 DOI: 10.7554/Elife.49041  0.827
2019 Hughson AR, Horvath AP, Holl K, Palmer AA, Solberg Woods LC, Robinson TE, Flagel SB. Incentive salience attribution, "sensation-seeking" and "novelty-seeking" are independent traits in a large sample of male and female heterogeneous stock rats. Scientific Reports. 9: 2351. PMID 30787409 DOI: 10.1038/S41598-019-39519-1  0.652
2019 Campus P, Covelo IR, Kim Y, Parsegian A, Kuhn BN, Lopez SA, Neumaier JF, Ferguson SM, Woods LCS, Sarter M, Flagel SB. Author response: The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats Elife. DOI: 10.7554/Elife.49041.046  0.82
2019 Flagel S. The paraventricular nucleus of the thalamus: A critical node for mediating individual differences in cue-motivated behaviors Ibro Reports. 6: S42. DOI: 10.1016/j.ibror.2019.07.126  0.332
2018 Wardle MC, Lopez-Gamundi P, Flagel SB. Measuring appetitive conditioned responses in humans. Physiology & Behavior. PMID 29408238 DOI: 10.1016/J.Physbeh.2018.02.004  0.442
2018 Joyner MA, Gearhardt AN, Flagel SB. A Translational Model to Assess Sign-Tracking and Goal-Tracking Behavior in Children. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 43: 228-229. PMID 29192653 DOI: 10.1038/Npp.2017.196  0.303
2017 Kuhn BN, Klumpner MS, Covelo IR, Campus P, Flagel SB. Transient inactivation of the paraventricular nucleus of the thalamus enhances cue-induced reinstatement in goal-trackers, but not sign-trackers. Psychopharmacology. PMID 29285634 DOI: 10.1007/S00213-017-4816-1  0.826
2017 Mabrouk OS, Han JL, Wong JT, Akil H, Kennedy RT, Flagel SB. In vivo neurochemical profile of selectively bred high-responder and low-responder rats reveals baseline, cocaine- and novelty-evoked differences in monoaminergic systems. Acs Chemical Neuroscience. PMID 29161023 DOI: 10.1021/Acschemneuro.7B00294  0.614
2017 Turner CA, Flagel SB, Blandino P, Watson SJ, Akil H. Utilizing a unique animal model to better understand human temperament. Current Opinion in Behavioral Sciences. 14: 108-114. PMID 28966969 DOI: 10.1016/J.Cobeha.2017.02.002  0.555
2017 Flagel SB, Robinson TE. Neurobiological Basis of Individual Variation in Stimulus-Reward Learning. Current Opinion in Behavioral Sciences. 13: 178-185. PMID 28670608 DOI: 10.1016/j.cobeha.2016.12.004  0.708
2017 García-Fuster MJ, Parsegian A, Watson SJ, Akil H, Flagel SB. Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats. Psychopharmacology. PMID 28210781 DOI: 10.1007/s00213-017-4566-0  0.626
2016 Haight JL, Fuller ZL, Fraser KM, Flagel SB. A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus. Neuroscience. PMID 27793779 DOI: 10.1016/J.Neuroscience.2016.10.043  0.828
2016 Flagel SB, Chaudhury S, Waselus M, Kelly R, Sewani S, Clinton SM, Thompson RC, Watson SJ, Akil H. Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114539 DOI: 10.1073/Pnas.1520491113  0.772
2016 Fraser KM, Haight JL, Gardner EL, Flagel SB. Examining the role of dopamine D2 and D3 receptors in Pavlovian conditioned approach behaviors. Behavioural Brain Research. PMID 26909847 DOI: 10.1016/J.Bbr.2016.02.022  0.799
2016 Morrow JD, Flagel SB. Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior. Progress in Brain Research. 223: 3-18. PMID 26806768 DOI: 10.1016/Bs.Pbr.2015.09.004  0.447
2015 Haight JL, Fraser KM, Akil H, Flagel SB. Lesions of the paraventricular nucleus of the thalamus differentially affect sign- and goal-tracking conditioned responses. The European Journal of Neuroscience. 42: 2478-88. PMID 26228683 DOI: 10.1111/Ejn.13031  0.835
2015 Pitchers KK, Flagel SB, O'Donnell EG, Woods LC, Sarter M, Robinson TE. Individual variation in the propensity to attribute incentive salience to a food cue: influence of sex. Behavioural Brain Research. 278: 462-9. PMID 25446811 DOI: 10.1016/j.bbr.2014.10.036  0.652
2015 Yager LM, Pitchers KK, Flagel SB, Robinson TE. Individual variation in the motivational and neurobiological effects of an opioid cue. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1269-77. PMID 25425322 DOI: 10.1038/Npp.2014.314  0.838
2015 Lesaint F, Sigaud O, Clark JJ, Flagel SB, Khamassi M. Experimental predictions drawn from a computational model of sign-trackers and goal-trackers. Journal of Physiology, Paris. 109: 78-86. PMID 24954026 DOI: 10.1016/J.Jphysparis.2014.06.001  0.489
2014 Huys QJ, Tobler PN, Hasler G, Flagel SB. The role of learning-related dopamine signals in addiction vulnerability. Progress in Brain Research. 211: 31-77. PMID 24968776 DOI: 10.1016/B978-0-444-63425-2.00003-9  0.406
2014 Haight JL, Flagel SB. A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses. Frontiers in Behavioral Neuroscience. 8: 79. PMID 24672443 DOI: 10.3389/Fnbeh.2014.00079  0.868
2014 Lesaint F, Sigaud O, Flagel SB, Robinson TE, Khamassi M. Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations. Plos Computational Biology. 10: e1003466. PMID 24550719 DOI: 10.1371/Journal.Pcbi.1003466  0.64
2014 Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA. Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology. 76: 250-8. PMID 23791960 DOI: 10.1016/J.Neuropharm.2013.05.047  0.598
2014 Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H. Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology. 76: 425-36. PMID 23639434 DOI: 10.1016/J.Neuropharm.2013.04.033  0.772
2013 Fitzpatrick CJ, Gopalakrishnan S, Cogan ES, Yager LM, Meyer PJ, Lovic V, Saunders BT, Parker CC, Gonzales NM, Aryee E, Flagel SB, Palmer AA, Robinson TE, Morrow JD. Variation in the form of Pavlovian conditioned approach behavior among outbred male Sprague-Dawley rats from different vendors and colonies: sign-tracking vs. goal-tracking. Plos One. 8: e75042. PMID 24098363 DOI: 10.1371/Journal.Pone.0075042  0.773
2013 Waselus M, Flagel SB, Jedynak JP, Akil H, Robinson TE, Watson SJ. Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats. Neuroscience. 248: 571-84. PMID 23811073 DOI: 10.1016/J.Neuroscience.2013.06.042  0.814
2013 Perez-Sepulveda JA, Flagel SB, Garcia-Fuster MJ, Slusky RJ, Aldridge JW, Watson S, Akil H. Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience. 248: 436-47. PMID 23806722 DOI: 10.1016/j.neuroscience.2013.06.015  0.581
2012 García-Fuster MJ, Flagel SB, Mahmood ST, Watson SJ, Akil H. Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. Plos One. 7: e42092. PMID 22860061 DOI: 10.1371/journal.pone.0042092  0.527
2012 Clinton SM, Turner CA, Flagel SB, Simpson DN, Watson SJ, Akil H. Neonatal fibroblast growth factor treatment enhances cocaine sensitization. Pharmacology, Biochemistry, and Behavior. 103: 6-17. PMID 22819969 DOI: 10.1016/J.Pbb.2012.07.006  0.751
2012 Meyer PJ, Lovic V, Saunders BT, Yager LM, Flagel SB, Morrow JD, Robinson TE. Quantifying individual variation in the propensity to attribute incentive salience to reward cues. Plos One. 7: e38987. PMID 22761718 DOI: 10.1371/Journal.Pone.0038987  0.824
2011 Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE. A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience. 196: 80-96. PMID 21945724 DOI: 10.1016/J.Neuroscience.2011.09.004  0.747
2011 García-Fuster MJ, Flagel SB, Mahmood ST, Mayo LM, Thompson RC, Watson SJ, Akil H. Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2303-17. PMID 21796105 DOI: 10.1038/npp.2011.119  0.567
2011 Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H. A selective role for dopamine in stimulus-reward learning. Nature. 469: 53-7. PMID 21150898 DOI: 10.1038/nature09588  0.802
2011 Burghardt PR, Flagel SB, Burghardt KJ, Britton SL, Gerard-Koch L, Watson SJ, Akil H. Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 390-401. PMID 20927049 DOI: 10.1038/npp.2010.144  0.566
2010 Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 388-400. PMID 19794408 DOI: 10.1038/npp.2009.142  0.84
2009 Turner CA, Capriles N, Flagel SB, Perez JA, Clinton SM, Watson SJ, Akil H. Neonatal FGF2 alters cocaine self-administration in the adult rat. Pharmacology, Biochemistry, and Behavior. 92: 100-4. PMID 19014962 DOI: 10.1016/J.Pbb.2008.10.018  0.801
2009 Robinson TE, Flagel SB. Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differences. Biological Psychiatry. 65: 869-73. PMID 18930184 DOI: 10.1016/j.biopsych.2008.09.006  0.622
2009 Flagel SB, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction. Neuropharmacology. 56: 139-48. PMID 18619474 DOI: 10.1016/j.neuropharm.2008.06.027  0.754
2008 Turner CA, Flagel SB, Clinton SM, Akil H, Watson SJ. Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat. Neuroscience Letters. 446: 105-7. PMID 18824081 DOI: 10.1016/J.Neulet.2008.09.037  0.764
2008 Briand LA, Flagel SB, Garcia-Fuster MJ, Watson SJ, Akil H, Sarter M, Robinson TE. Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2969-80. PMID 18305460 DOI: 10.1038/npp.2008.18  0.789
2008 Briand LA, Flagel SB, Seeman P, Robinson TE. Cocaine self-administration produces a persistent increase in dopamine D2 High receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 551-6. PMID 18284941 DOI: 10.1016/j.euroneuro.2008.01.002  0.771
2008 Flagel SB, Watson SJ, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behavioural Brain Research. 186: 48-56. PMID 17719099 DOI: 10.1016/j.bbr.2007.07.022  0.75
2007 Flagel SB, Robinson TE. Quantifying the psychomotor activating effects of cocaine in the rat. Behavioural Pharmacology. 18: 297-302. PMID 17551322 DOI: 10.1097/FBP.0b013e3281f522a4  0.616
2007 Flagel SB, Watson SJ, Robinson TE, Akil H. Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats. Psychopharmacology. 191: 599-607. PMID 16972103 DOI: 10.1007/s00213-006-0535-8  0.732
2004 Flagel S, Simmons T, Robinson T, Akil H. P26 INDIVIDUAL DIFFERENCES IN PAVLOVIAN CONDITIONED APPROACH BEHAVIOR Behavioural Pharmacology. 15: A15-A16. DOI: 10.1097/00008877-200409000-00066  0.633
2003 Flagel SB, Vázquez DM, Robinson TE. Manipulations during the second, but not the first, week of life increase susceptibility to cocaine self-administration in female rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1741-51. PMID 12888774 DOI: 10.1038/Sj.Npp.1300228  0.597
2002 Flagel SB, Vázquez DM, Watson SJ, Neal CR. Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R55-63. PMID 11742823 DOI: 10.1152/Ajpregu.2002.282.1.R55  0.308
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