| Year |
Citation |
Score |
| 2023 |
Song Q, Ruiz J, Xing F, Lo HW, Craddock L, Pullikuth AK, Miller LD, Soike MH, O'Neill SS, Watabe K, Chan MD, Su J. Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment. Communications Biology. 6: 760. PMID 37479733 DOI: 10.1038/s42003-023-05124-2 |
0.345 |
|
| 2023 |
Arrigo A, Regua AT, Najjar MK, Lo HW. Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy. Cancers. 15. PMID 37173921 DOI: 10.3390/cancers15092455 |
0.366 |
|
| 2022 |
Doheny D, Manore S, Sirkisoon SR, Zhu D, Aguayo NR, Harrison A, Najjar M, Anguelov M, Cox AO, Furdui CM, Watabe K, Hollis T, Thomas A, Strowd R, Lo HW. An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1. Cancers. 14. PMID 36077791 DOI: 10.3390/cancers14174256 |
0.327 |
|
| 2022 |
Wong GL, Manore SG, Doheny DL, Lo HW. STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges. Seminars in Cancer Biology. PMID 35995341 DOI: 10.1016/j.semcancer.2022.08.003 |
0.342 |
|
| 2022 |
Regua AT, Najjar M, Lo HW. RET signaling pathway and RET inhibitors in human cancer. Frontiers in Oncology. 12: 932353. PMID 35957881 DOI: 10.3389/fonc.2022.932353 |
0.401 |
|
| 2021 |
Regua AT, Aguayo NR, Jalboush SA, Doheny DL, Manore SG, Zhu D, Wong GL, Arrigo A, Wagner CJ, Yu Y, Thomas A, Chan MD, Ruiz J, Jin G, Strowd R, ... ... Lo HW, et al. TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers. Cancers. 13. PMID 34066153 DOI: 10.3390/cancers13102340 |
0.346 |
|
| 2021 |
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, ... ... Lo HW, et al. Correction: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. PMID 33654200 DOI: 10.1038/s41388-020-01620-5 |
0.333 |
|
| 2020 |
Wang G, Wang J, Chang A, Cheng D, Huang S, Wu D, Sirkisoon S, Yang S, Lin HK, Lo HW, Xiang R, Sun P. Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2. Oncogene. PMID 32989258 DOI: 10.1038/s41388-020-01481-y |
0.323 |
|
| 2020 |
Doheny D, Manore SG, Wong GL, Lo HW. Hedgehog Signaling and Truncated GLI1 in Cancer. Cells. 9. PMID 32957513 DOI: 10.3390/Cells9092114 |
0.475 |
|
| 2020 |
Doheny D, Sirkisoon S, Carpenter RL, Aguayo NR, Regua AT, Anguelov M, Manore SG, Arrigo A, Jalboush SA, Wong GL, Yu Y, Wagner CJ, Chan M, Ruiz J, Thomas A, ... ... Lo HW, et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis. Oncogene. PMID 32929154 DOI: 10.1038/S41388-020-01454-1 |
0.457 |
|
| 2020 |
Wong GL, Abu Jalboush S, Lo HW. Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis. Cancers. 12. PMID 32646059 DOI: 10.3390/Cancers12071827 |
0.364 |
|
| 2020 |
Pan L, Chen X, Fu S, Yu W, Li C, Wang T, Lo HW, Lin J. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. Breast Cancer Research and Treatment. PMID 32240456 DOI: 10.1007/S10549-020-05613-6 |
0.425 |
|
| 2020 |
Pan L, Chen X, Fu S, Li C, Lo H, Lin J. Abstract P5-05-11: Novel small molecule STAT3 inhibitors induce apoptosis and suppress cell migration and tumor growth in triple-negative breast cancer cells Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P5-05-11 |
0.451 |
|
| 2020 |
Doheny DL, Sirkisoon SR, Rimkus T, Zhu D, Aguayo NR, Harrison A, Anguelov M, Manore S, Xing F, Metheny-Barlow LJ, Watabe K, Thomas A, Masters AH, Strowd R, Lo H. Abstract 5025: Antifungal ketoconazole inhibits tumor-specific transcription factor tGLI1 leading to suppression of breast cancer stem cells and brain metastasis Cancer Research. 80: 5025-5025. DOI: 10.1158/1538-7445.Am2020-5025 |
0.458 |
|
| 2020 |
Doheny D, Sirkisoon S, Rimkus T, Zhu D, Aguayo N, Anguelov M, Manore S, Regua A, Thomas A, Henson-Masters A, Strowd R, Lo H. 54. tGLI1 IS AN ACTIONABLE THERAPEUTIC TARGET IN BREAST CANCER BRAIN METASTASES Neuro-Oncology Advances. 2: ii11-ii11. DOI: 10.1093/noajnl/vdaa073.042 |
0.351 |
|
| 2019 |
Regua AT, Doheny D, Arrigo A, Lo HW. Trk receptor tyrosine kinases in metastasis and cancer therapy. Discovery Medicine. 28: 195-203. PMID 31928627 |
0.386 |
|
| 2019 |
Soike MH, Logue J, Qasem S, Hughes RT, McTyre E, Su J, Triozzi P, Bendandi M, Lo HW, Ahmed T, O'Neill SS, Debinski W, Pasche B, Watabe K, Miller LD, et al. CD138 plasma cells may predict brain metastasis recurrence following resection and stereotactic radiosurgery. Scientific Reports. 9: 14385. PMID 31591443 DOI: 10.1038/S41598-019-50298-7 |
0.333 |
|
| 2019 |
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Regua AT, Arrigo A, Anguelov M, ... ... Lo HW, et al. TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment. Oncogene. PMID 31462709 DOI: 10.1038/S41388-019-0959-3 |
0.464 |
|
| 2019 |
Sharma S, Wu SY, Jimenez H, Xing F, Zhu D, Liu Y, Wu K, Tyagi A, Zhao D, Lo HW, Metheny-Barlow L, Sun P, Bourland JD, Chan MD, Thomas A, et al. Ca and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF. Ebiomedicine. PMID 31129098 DOI: 10.1016/J.Ebiom.2019.05.038 |
0.371 |
|
| 2019 |
Dohm A, Su J, McTyre ER, Taylor JM, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow LJ, O'Neill S, Bellinger C, Dotson T, Pasche B, Watabe K, Chan MD, et al. Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial. The International Journal of Biological Markers. 1724600818803104. PMID 30854931 DOI: 10.1177/1724600818803104 |
0.347 |
|
| 2019 |
Tian J, Chen X, Fu S, Zhang R, Pan L, Cao Y, Wu X, Xiao H, Lin HJ, Lo HW, Zhang Y, Lin J. Bazedoxifene is a novel IL-6/GP130 inhibitor for treating triple-negative breast cancer. Breast Cancer Research and Treatment. PMID 30852762 DOI: 10.1007/S10549-019-05183-2 |
0.396 |
|
| 2019 |
Fu S, Chen X, Lo HW, Lin J. Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer. Cancer Letters. PMID 30707920 DOI: 10.1016/J.Canlet.2019.01.026 |
0.454 |
|
| 2019 |
Tenvooren I, Jenks MZ, Rashid H, Cook KL, Muhlemann JK, Sistrunk C, Holmes J, Wang K, Bonin K, Hodges K, Lo HW, Shaikh A, Camarillo IG, Lelièvre SA, Seewaldt V, et al. Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland. Oncogene. PMID 30670780 DOI: 10.1038/S41388-019-0687-8 |
0.335 |
|
| 2019 |
Sirkisoon SR, Carpenter RL, Rimkus T, Doheny D, Zhu D, Aguayo NR, Anguelov M, Arrigo A, Xing F, Chan M, Ruiz J, Metheny-Barlow LJ, Strowd R, Lin J, Pasche BC, ... ... Lo H, et al. Abstract 3689: Tumor-specific gain-of-function tGLI1 transcription factor is a novel mediator of breast cancer stem cells and a novel transcriptional activator of cancer stemness genes Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3689 |
0.435 |
|
| 2019 |
Rimkus TK, Zhu D, Carpenter RL, Paw I, Arrigo A, Sirkisoon S, Doheny D, Aguayo N, Lee J, Jin G, Spooner E, Pasche B, Debinski W, Lo H. Abstract 3481: Roles of tumor suppressor candidate 2 (TUSC2) in glioblastoma progression and gliomagenesis Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3481 |
0.321 |
|
| 2019 |
Sirkisoon S, Carpenter R, Rimkus T, Doheny D, Zhu D, Aguayo N, Anguelov M, Arrigo A, Regua A, Xing F, Chan M, Metheny-Barlow L, Watabe K, Lo H. BSCI-13. TUMOR-SPECIFIC tGLI1 TRANSCRIPTION FACTOR MEDIATES BREAST CANCER BRAIN METASTASIS VIA ACTIVATING METASTASIS-INITIATING CANCER STEM CELLS AND ASTROCYTES IN THE TUMOR MICROENVIRONMENT Neuro-Oncology Advances. 1: i3-i3. DOI: 10.1093/noajnl/vdz014.011 |
0.379 |
|
| 2019 |
Doheny D, Sirkisoon S, Rimkus T, Zhu D, Aguayo N, Harrison A, Anguelov M, Xing F, Metheny-Barlow L, Watabe K, Thomas A, Masters AH, Strowd R, Lo H. BSCI-02. tGLI1 IS A NOVEL, ACTIONABLE TARGET FOR THE TREATMENT OF BREAST CANCER BRAIN METASTASES Neuro-Oncology Advances. 1: i1-i1. DOI: 10.1093/noajnl/vdz014.001 |
0.333 |
|
| 2018 |
Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, ... ... Lo HW, et al. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Research. PMID 30026327 DOI: 10.1158/0008-5472.Can-18-1102 |
0.436 |
|
| 2018 |
Lange AM, Lo HW. Inhibiting TRK Proteins in Clinical Cancer Therapy. Cancers. 10. PMID 29617282 DOI: 10.3390/Cancers10040105 |
0.469 |
|
| 2018 |
Rimkus TK, Carpenter RL, Sirkisoon SR, Zhu D, Pasche B, Chan MD, Lesser GJ, Tatter SB, Watabe K, Debinski W, Lo HW. Truncated glioma-associated oncogene homolog 1 (tGLI1) mediates mesenchymal glioblastoma via transcriptional activation of CD44. Cancer Research. PMID 29463580 DOI: 10.1158/0008-5472.Can-17-2933 |
0.435 |
|
| 2018 |
Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW. Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Oncogene. PMID 29449694 DOI: 10.1038/S41388-018-0132-4 |
0.436 |
|
| 2018 |
Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, et al. Use of non-ionizing electromagnetic fields for the treatment of cancer. Frontiers in Bioscience (Landmark Edition). 23: 284-297. PMID 28930547 DOI: 10.2741/4591 |
0.366 |
|
| 2017 |
Lanier CM, McTyre E, LeCompte M, Cramer CK, Hughes R, Watabe K, Lo HW, O'Neill S, Munley MT, Laxton AW, Tatter SB, Ruiz J, Chan MD. The number of prior lines of systemic therapy as a prognostic factor for patients with brain metastases treated with stereotactic radiosurgery: Results of a large single institution retrospective analysis. Clinical Neurology and Neurosurgery. 165: 24-28. PMID 29289917 DOI: 10.1016/J.Clineuro.2017.12.021 |
0.318 |
|
| 2017 |
Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, ... Lo HW, et al. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. 8: 73947-73963. PMID 29088759 DOI: 10.18632/Oncotarget.18166 |
0.428 |
|
| 2017 |
Rimkus T, Sirkisoon S, Harrison A, Lo HW. Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers. Discovery Medicine. 23: 325-330. PMID 28715648 |
0.382 |
|
| 2017 |
Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, ... Lo HW, et al. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. PMID 28598816 DOI: 10.18632/oncotarget.18166 |
0.322 |
|
| 2017 |
Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. PMID 28511975 DOI: 10.1016/J.Jocn.2017.04.033 |
0.356 |
|
| 2017 |
Dohm A, Su J, McTyre E, Soike M, Miller L, Petty W, Xing F, Lo H, Metheny-Barlow L, Watabe K, Chan M, Ruiz J, Pasche B. Determination of Tumor Gene Expression in Non–small Cell Lung Cancer Patients Who Develop Brain Metastasis Diagnosis: Analysis of a Prospective Trial International Journal of Radiation Oncology*Biology*Physics. 99: E453. DOI: 10.1016/J.Ijrobp.2017.06.1687 |
0.315 |
|
| 2016 |
Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW. Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers. 8. PMID 26891329 DOI: 10.3390/Cancers8020022 |
0.443 |
|
| 2016 |
Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW. EGFR and HER2 signaling in breast cancer brain metastasis. Frontiers in Bioscience (Elite Edition). 8: 245-63. PMID 26709660 DOI: 10.2741/765 |
0.415 |
|
| 2016 |
Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S. Biology and treatment of metastasis of sarcoma to the brain. Frontiers in Bioscience (Elite Edition). 8: 233-44. PMID 26709659 DOI: 10.2741/E764 |
0.358 |
|
| 2015 |
Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW. The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Oncotarget. 6: 22653-65. PMID 26093087 DOI: 10.18632/Oncotarget.4248 |
0.355 |
|
| 2015 |
Paw I, Carpenter RC, Watabe K, Debinski W, Lo HW. Mechanisms regulating glioma invasion. Cancer Letters. 362: 1-7. PMID 25796440 DOI: 10.1016/J.Canlet.2015.03.015 |
0.38 |
|
| 2015 |
Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K. miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-α Oncogene. PMID 25659578 DOI: 10.1038/Onc.2014.412 |
0.367 |
|
| 2015 |
Carpenter RL, Paw I, Dewhirst MW, Lo H. Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial–mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells Oncogene. 34: 546-557. PMID 24469056 DOI: 10.1038/Onc.2013.582 |
0.395 |
|
| 2015 |
Carpenter RL, Paw I, Sirkisoon S, Xing F, Gibo D, Watabe K, Debinski W, Lo H. Abstract 4165: The gain-of-function truncated GLI1 (TGLI1) promotes glioblastoma angiogenesis by direct upregulation of VEGF-C and TEM7 expression Cancer Research. 75: 4165-4165. DOI: 10.1158/1538-7445.Am2015-4165 |
0.397 |
|
| 2014 |
Carpenter RL, Lo HW. STAT3 Target Genes Relevant to Human Cancers. Cancers. 6: 897-925. PMID 24743777 DOI: 10.3390/cancers6020897 |
0.377 |
|
| 2014 |
Zhu H, Carpenter RL, Han W, Lo HW. The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth. Cancer Letters. 343: 51-61. PMID 24045042 DOI: 10.1016/J.Canlet.2013.09.014 |
0.409 |
|
| 2013 |
Carpenter RL, Lo HW. Regulation of Apoptosis by HER2 in Breast Cancer. Journal of Carcinogenesis & Mutagenesis. 2013. PMID 27088047 DOI: 10.4172/2157-2518.S7-003 |
0.452 |
|
| 2013 |
Carpenter RL, Han W, Paw I, Lo HW. HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. Plos One. 8: e78836. PMID 24236056 DOI: 10.1371/Journal.Pone.0078836 |
0.452 |
|
| 2013 |
Lo HW. Akt destabilizes p57 (Kip2) : Akt at the converging crossroad? Cell Cycle (Georgetown, Tex.). 12: 870-1. PMID 23470457 DOI: 10.4161/Cc.24155 |
0.488 |
|
| 2013 |
Han W, Carpenter RL, Cao X, Lo HW. STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3. Molecular Carcinogenesis. 52: 959-69. PMID 22693070 DOI: 10.1002/Mc.21936 |
0.498 |
|
| 2012 |
Carpenter RL, Lo HW. Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer. Journal of Thoracic Disease. 4: 639-42. PMID 23205292 DOI: 10.3978/J.Issn.2072-1439.2012.10.09 |
0.419 |
|
| 2012 |
Huang X, Yuan F, Liang M, Lo HW, Shinohara ML, Robertson C, Zhong P. M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. Plos One. 7: e41632. PMID 22911830 DOI: 10.1371/Journal.Pone.0041632 |
0.349 |
|
| 2012 |
Carpenter RL, Lo HW. Identification, functional characterization, and pathobiological significance of GLI1 isoforms in human cancers. Vitamins and Hormones. 88: 115-40. PMID 22391302 DOI: 10.1016/B978-0-12-394622-5.00006-7 |
0.48 |
|
| 2012 |
Carpenter RL, Lo HW. Hedgehog pathway and GLI1 isoforms in human cancer. Discovery Medicine. 13: 105-13. PMID 22369969 |
0.409 |
|
| 2012 |
Han W, Lo HW. Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Letters. 318: 124-34. PMID 22261334 DOI: 10.1016/J.Canlet.2012.01.011 |
0.47 |
|
| 2012 |
Cao X, Geradts J, Dewhirst M, Lo H. Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells Oncogene. 31: 104-115. PMID 21666711 DOI: 10.1038/Onc.2011.219 |
0.402 |
|
| 2011 |
Cao X, Zhu H, Ali-Osman F, Lo HW. EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis. Molecular Cancer. 10: 26. PMID 21388543 DOI: 10.1186/1476-4598-10-26 |
0.611 |
|
| 2011 |
Cao X, Dewhirst M, Ali-Osman F, Lo H. Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression Cancer Research. 71: 2337-2337. DOI: 10.1158/1538-7445.Am2011-2337 |
0.658 |
|
| 2010 |
Zhu H, Lo HW. The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases. Current Genomics. 11: 238-45. PMID 21119888 DOI: 10.2174/138920210791233108 |
0.457 |
|
| 2010 |
Lo HW. Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas. Current Cancer Drug Targets. 10: 840-8. PMID 20718706 DOI: 10.2174/156800910793357970 |
0.371 |
|
| 2010 |
Lo HW. Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications. Discovery Medicine. 10: 44-51. PMID 20670598 |
0.366 |
|
| 2010 |
Zhu H, Cao X, Ali-Osman F, Keir S, Lo HW. EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Letters. 294: 101-10. PMID 20153921 DOI: 10.1016/J.Canlet.2010.01.028 |
0.624 |
|
| 2010 |
Lo HW, Cao X, Zhu H, Ali-Osman F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Molecular Cancer Research : McR. 8: 232-45. PMID 20145033 DOI: 10.1158/1541-7786.Mcr-09-0391 |
0.651 |
|
| 2010 |
Lo HW. EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance. Current Molecular Pharmacology. 3: 37-52. PMID 20030624 DOI: 10.2174/1874467211003010037 |
0.418 |
|
| 2010 |
Zhu H, Cao X, Keir S, Ali-Osman F, Lo H. Abstract LB-225: EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-225 |
0.653 |
|
| 2010 |
Zhu H, Cao X, Ali-Osman F, Lo H. Abstract 414: Identification and functional characterization of a novel tumor-specific gain-of-function GLI1 splice variant that promotes cancer migration and invasion Cancer Research. 70: 414-414. DOI: 10.1158/1538-7445.Am10-414 |
0.663 |
|
| 2010 |
Lo H, Cao X, Zhu H, Ali-Osman F. Abstract 3117: COX-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes Cancer Research. 70: 3117-3117. DOI: 10.1158/1538-7445.Am10-3117 |
0.663 |
|
| 2009 |
Lo HW, Zhu H, Cao X, Aldrich A, Ali-Osman F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Research. 69: 6790-8. PMID 19706761 DOI: 10.1158/0008-5472.Can-09-0886 |
0.668 |
|
| 2008 |
Lo HW, Cao X, Zhu H, Ali-Osman F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6042-54. PMID 18829483 DOI: 10.1158/1078-0432.Ccr-07-4923 |
0.611 |
|
| 2008 |
Lo HW, Stephenson L, Cao X, Milas M, Pollock R, Ali-Osman F. Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. Molecular Cancer Research : McR. 6: 843-50. PMID 18505928 DOI: 10.1158/1541-7786.Mcr-07-2105 |
0.574 |
|
| 2007 |
Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Research. 67: 9066-76. PMID 17909010 DOI: 10.1158/0008-5472.CAN-07-0575 |
0.428 |
|
| 2007 |
Lo HW, Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Current Opinion in Pharmacology. 7: 367-74. PMID 17681492 DOI: 10.1016/J.Coph.2007.06.009 |
0.602 |
|
| 2006 |
Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. British Journal of Cancer. 94: 184-8. PMID 16434982 DOI: 10.1038/sj.bjc.6602941 |
0.365 |
|
| 2006 |
Hanada N, Lo HW, Day CP, Pan Y, Nakajima Y, Hung MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis. 45: 10-7. PMID 16299810 DOI: 10.1002/mc.20147 |
0.343 |
|
| 2006 |
Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Research and Treatment. 95: 211-8. PMID 16261406 DOI: 10.1007/s10549-005-9011-0 |
0.403 |
|
| 2005 |
Lo HW, Day CP, Hung MC. Cancer-Specific Gene Therapy Advances in Genetics. 54: 233-255. PMID 16096014 DOI: 10.1016/S0065-2660(05)54010-0 |
0.399 |
|
| 2005 |
Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 7: 575-89. PMID 15950906 DOI: 10.1016/j.ccr.2005.05.007 |
0.329 |
|
| 2005 |
Lo HW, Xia W, Wei Y, Ali-Seyed M, Huang SF, Hung MC. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Research. 65: 338-48. PMID 15665312 |
0.342 |
|
| 2004 |
Lo HW, Antoun GR, Ali-Osman F. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Research. 64: 9131-8. PMID 15604283 DOI: 10.1158/0008-5472.Can-04-0283 |
0.573 |
|
| 2004 |
Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 6: 251-61. PMID 15380516 DOI: 10.1016/j.ccr.2004.07.012 |
0.374 |
|
| 2004 |
Lee CM, Lo HW, Shao RP, Wang SC, Xia W, Gershenson DM, Hung MC. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. Cancer Research. 64: 1788-93. PMID 14996741 DOI: 10.1158/0008-5472.CAN-03-2551 |
0.367 |
|
| 2002 |
Lo HW, Ali-Osman F. Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. Journal of Cellular Biochemistry. 87: 103-16. PMID 12210727 DOI: 10.1002/Jcb.10275 |
0.659 |
|
| 1998 |
Lo HW, Ali-Osman F. Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. Chemico-Biological Interactions. 111: 91-102. PMID 9679546 DOI: 10.1016/S0009-2797(97)00153-1 |
0.594 |
|
| 1997 |
Lo HW, Ali-Osman F. Genomic cloning of hGSTP1*C, an allelic human Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements. The Journal of Biological Chemistry. 272: 32743-9. PMID 9407047 DOI: 10.1074/Jbc.272.52.32743 |
0.586 |
|
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