Mien-Chie Hung - Publications

The University of Texas Graduate School of Biomedical Sciences at Houston 
Oncology, Molecular Biology, Biomedical Engineering

315 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, ... ... Hung MC, et al. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. American Journal of Cancer Research. 10: 648-661. PMID 32195033  0.72
2020 Sun X, Li CW, Wang WJ, Chen MK, Li H, Lai YJ, Hsu JL, Koller PB, Chan LC, Lee PC, Cheng FJ, Yam C, Chen GY, Hung MC. Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma. American Journal of Cancer Research. 10: 564-571. PMID 32195027  0.92
2020 Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, ... ... Hung MC, et al. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 37: 324-339.e8. PMID 32183950 DOI: 10.1016/j.ccell.2020.02.006  0.72
2020 Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, ... ... Hung MC, et al. Targeting glycosylated PD-1 induces potent anti-tumor immunity. Cancer Research. PMID 32156778 DOI: 10.1158/0008-5472.CAN-19-3133  0.92
2020 Chou CK, Liu YL, Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Lee JF, Yankeelov TE, Kameoka J, Yeh HC, Hung MC. Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies. Acs Sensors. PMID 32073836 DOI: 10.1021/acssensors.9b01736  0.96
2020 Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, ... ... Hung MC, et al. Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nature Communications. 11: 673. PMID 31996688 DOI: 10.1038/s41467-020-14429-3  0.92
2020 Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, et al. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics. 10: 201-217. PMID 31903115 DOI: 10.7150/thno.35895  0.72
2019 Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. American Journal of Cancer Research. 9: 2719-2729. PMID 31911857  0.64
2019 Yen YT, Chien M, Lai YC, Chen DP, Chuong CM, Hung MC, Hung SC. PP2A Deficiency Enhances Carcinogenesis of Lgr5 Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 9. PMID 31905853 DOI: 10.3390/cells9010090  0.92
2019 Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nature Communications. 10: 5654. PMID 31827085 DOI: 10.1038/s41467-019-13508-4  0.68
2019 Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, ... ... Hung MC, et al. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nature Communications. 10: 5114. PMID 31704972 DOI: 10.1038/s41467-019-13105-5  0.92
2019 Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Bai X, Sun B, Hung MC, Liu L, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Molecular Cancer. 18: 156. PMID 31694640 DOI: 10.1186/s12943-019-1077-0  0.64
2019 Cha JH, Chan LC, Li CW, Hsu JL, Hung MC. Mechanisms Controlling PD-L1 Expression in Cancer. Molecular Cell. PMID 31668929 DOI: 10.1016/j.molcel.2019.09.030  0.8
2019 Cha JH, Chan LC, Song MS, Hung MC. New Approaches on Cancer Immunotherapy. Cold Spring Harbor Perspectives in Medicine. PMID 31615865 DOI: 10.1101/cshperspect.a036863  0.72
2019 Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, et al. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. PMID 31554935 DOI: 10.1038/s41388-019-1010-4  0.72
2019 Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, et al. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nature Communications. 10: 4363. PMID 31554794 DOI: 10.1038/s41467-019-12377-1  0.8
2019 Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A Chirality-Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics. International Journal of Cancer. PMID 31472018 DOI: 10.1002/ijc.32658  0.8
2019 Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. The Journal of Cell Biology. PMID 31387940 DOI: 10.1083/jcb.201901156  0.76
2019 Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Wei Y, Chou CK, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, ... ... Hung MC, et al. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Cancer Cell. PMID 31327656 DOI: 10.1016/j.ccell.2019.06.008  0.92
2019 Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, ... ... Hung MC, et al. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. The Journal of Clinical Investigation. 130. PMID 31305264 DOI: 10.1172/JCI126022  0.92
2019 Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, ... ... Hung MC, et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology. PMID 31160797 DOI: 10.1038/s41590-019-0400-7  0.8
2019 Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J, Hung MC. HOinduces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bounded retrograde trafficking mechanism. The Journal of Biological Chemistry. PMID 30962283 DOI: 10.1074/jbc.RA118.005953  0.72
2019 Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX, Nie L, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD, Hung MC. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. American Journal of Cancer Research. 9: 608-618. PMID 30949414  0.92
2019 Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, ... ... Hung MC, et al. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. PMID 30902885 DOI: 10.1136/gutjnl-2019-318419  0.8
2019 Lee HH, Wang YN, Hung MC. Functional roles of the human ribonuclease a superfamily in RNA metabolism and membrane receptor biology. Molecular Aspects of Medicine. PMID 30902663 DOI: 10.1016/j.mam.2019.03.003  0.76
2019 Lu S, Han Z, Hung MC, Xu J, Xu Y, Zheng P, Zheng ZM, Zou L, Li Z, Zheng L, Kang Y, Yang Y, He L, Liao XC, Yu H, et al. Racial profiling harms science. Science (New York, N.Y.). 363: 1290-1292. PMID 30898924 DOI: 10.1126/science.aaw6854  0.8
2019 Liu YL, Chou CK, Kim M, Vasisht R, Kuo YA, Ang P, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov TE, Hung MC, et al. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Scientific Reports. 9: 3395. PMID 30833579 DOI: 10.1038/s41598-018-37625-0  0.88
2019 Wang WJ, Hsu JM, Wang YN, Lee HH, Yamaguchi H, Liao HW, Hung MC. An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5. American Journal of Cancer Research. 9: 180-185. PMID 30755821  0.76
2019 Wang EM, Akasaka H, Zhao J, Varadhachary GR, Lee JE, Maitra A, Fleming JB, Hung MC, Wang H, Katz MHG. Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma. Pancreas. PMID 30747823 DOI: 10.1097/MPA.0000000000001248  0.72
2019 Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. The Journal of Clinical Investigation. PMID 30741721 DOI: 10.1172/JCI121987  0.72
2019 Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Billalabeitia EG, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nature Communications. 10: 636. PMID 30733438 DOI: 10.1038/s41467-019-08481-x  0.8
2019 Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, ... ... Hung MC, et al. MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology. PMID 30711629 DOI: 10.1053/j.gastro.2019.01.252  0.92
2019 Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, ... ... Hung MC, et al. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. PMID 30631154 DOI: 10.1038/s41422-018-0134-3  0.72
2018 Dong Q, Du Y, Li H, Liu C, Wei Y, Chen MK, Zhao X, Chu YY, Qiu Y, Qin L, Yamaguchi H, Hung MC. EGFR and c-MET cooperate to enhance resistance to PARP inhibitors in hepatocellular carcinoma. Cancer Research. PMID 30573522 DOI: 10.1158/0008-5472.CAN-18-1273  0.88
2018 Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, ... ... Hung MC, et al. Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 34: 954-969.e4. PMID 30537515 DOI: 10.1016/j.ccell.2018.11.007  1
2018 Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, et al. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. Journal of the National Cancer Institute. PMID 30534944 DOI: 10.1093/jnci/djy160  0.48
2018 Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y, Hung MC. Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Cell Research. PMID 30514902 DOI: 10.1038/s41422-018-0124-5  0.92
2018 Wang YN, Lee HH, Hung MC. A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases. Journal of Biomedical Science. 25: 83. PMID 30449278 DOI: 10.1186/s12929-018-0484-7  0.76
2018 Hsu JM, Li CW, Lai YJ, Hung MC. Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy. Cancer Research. 78: 6349-6353. PMID 30442814 DOI: 10.1158/0008-5472.CAN-18-1892  0.8
2018 Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X, Hung MC, Lin X. Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. The Journal of Biological Chemistry. PMID 30361438 DOI: 10.1074/jbc.RA118.005449  0.56
2018 Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, et al. Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Science Translational Medicine. 10. PMID 30355799 DOI: 10.1126/scitranslmed.aat3487  0.72
2018 Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, ... ... Hung MC, et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nature Genetics. PMID 30349115 DOI: 10.1038/s41588-018-0252-3  0.68
2018 Yam C, Hung MC, Hortobagyi GN. CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line? Oncotarget. 9: 34193-34195. PMID 30344934 DOI: 10.18632/oncotarget.26134  0.72
2018 Shao B, Li CW, Lim SO, Sun L, Lai YJ, Hou J, Liu C, Chang CW, Qiu Y, Hsu JM, Chan LC, Zha Z, Li H, Hung MC. Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. American Journal of Cancer Research. 8: 1837-1846. PMID 30323975  0.8
2018 Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W, Xia W, Rao PH, Zhao R, Hung MC, et al. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Research. 33: 36-40. PMID 30312871 DOI: 10.1016/j.scr.2018.10.003  0.88
2018 Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung MC, Lin X. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 49: 504-514.e4. PMID 30231984 DOI: 10.1016/j.immuni.2018.08.018  0.56
2018 Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nature Cell Biology. PMID 30202049 DOI: 10.1038/s41556-018-0178-0  0.88
2018 Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, ... ... Hung MC, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Molecular Cell. 71: 606-620.e7. PMID 30118680 DOI: 10.1016/j.molcel.2018.07.030  0.92
2018 Sun LL, Yang RY, Li CW, Chen MK, Shao B, Hsu JM, Chan LC, Yang Y, Hsu JL, Lai YJ, Hung MC. Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. American Journal of Cancer Research. 8: 1307-1316. PMID 30094103  0.92
2018 Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Mutant LKB1 confers enhanced radiosensitization in combination with trametinib in KRAS-mutant non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30068711 DOI: 10.1158/1078-0432.CCR-18-1489  0.8
2018 Li CW, Lai YJ, Hsu JL, Hung MC. Activation of phagocytosis by immune checkpoint blockade. Frontiers of Medicine. PMID 30062558 DOI: 10.1007/s11684-018-0657-5  0.8
2018 Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, ... ... Hung MC, et al. Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. Cancer Research. PMID 29967256 DOI: 10.1158/0008-5472.CAN-17-0385  0.72
2018 Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, Hung MC. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Research. PMID 29959401 DOI: 10.1038/s41422-018-0060-4  0.92
2018 Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC. A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues. Biosensors & Bioelectronics. 117: 97-103. PMID 29890396 DOI: 10.1016/j.bios.2018.05.053  0.88
2018 Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC. Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression. Cancer Research. PMID 29789418 DOI: 10.1158/0008-5472.CAN-18-0040  0.8
2018 Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, ... ... Hung MC, et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nature Communications. 9: 1908. PMID 29765039 DOI: 10.1038/s41467-018-04313-6  0.96
2018 Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, ... Hung MC, et al. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Research. 29: 215-219. PMID 29730572 DOI: 10.1016/j.scr.2018.04.013  0.88
2018 Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, ... ... Hung MC, et al. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports. 23: 823-837. PMID 29669287 DOI: 10.1016/j.celrep.2018.03.078  1
2018 Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY, Hung MC. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. American Journal of Cancer Research. 8: 514-525. PMID 29637005  0.8
2018 Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, ... ... Hung MC, et al. Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. Cancer Cell. PMID 29606349 DOI: 10.1016/j.ccell.2018.02.012  0.96
2018 Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, ... ... Hung MC, et al. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 33: 187-201.e10. PMID 29438695 DOI: 10.1016/j.ccell.2018.01.009  0.92
2018 Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. American Journal of Cancer Research. 8: 183-191. PMID 29416931  0.8
2018 Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, et al. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Research. 27: 131-135. PMID 29414603 DOI: 10.1016/j.scr.2018.01.035  0.88
2018 Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, ... ... Hung MC, et al. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Molecular Cell. 69: 279-291.e5. PMID 29351847 DOI: 10.1016/j.molcel.2017.12.024  0.92
2017 Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S. Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. American Journal of Cancer Research. 7: 2587-2599. PMID 29312811  0.88
2017 Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. The Journal of Clinical Investigation. PMID 29251629 DOI: 10.1172/JCI89212  0.64
2017 Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robotics. 4: 390-399. PMID 29251562 DOI: 10.1089/soro.2016.0073  0.96
2017 Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 7: 4805-4824. PMID 29187905 DOI: 10.7150/thno.20771  0.92
2017 Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis. Hepatology (Baltimore, Md.). PMID 29171033 DOI: 10.1002/hep.29678  0.88
2017 Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, ... Hung MC, et al. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. The Journal of Clinical Investigation. PMID 29130936 DOI: 10.1172/JCI91553  0.8
2017 Li CW, Lim SO, Hsu JL, Hung MC. Rational combination of immunotherapy for triple negative breast cancer treatment. Chinese Clinical Oncology. 6: 54. PMID 29129094 DOI: :10.21037/cco.2017.08.04  0.8
2017 Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, ... ... Hung MC, et al. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Science Translational Medicine. 9. PMID 29118262 DOI: 10.1126/scitranslmed.aao4307  0.64
2017 Liao HW, Hung MC. Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model. Bio-Protocol. 7. PMID 29104894 DOI: 10.21769/BioProtoc.2311  0.56
2017 Yang R, Hung MC. The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Science China. Life Sciences. PMID 29027155 DOI: 10.1007/s11427-017-9176-7  0.64
2017 Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Molecular Cell. 67: 733-743.e4. PMID 28844863 DOI: 10.1016/j.molcel.2017.07.026  0.88
2017 Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Martinez FP, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Molecular and Cellular Biology. PMID 28760776 DOI: 10.1128/MCB.00142-17  0.44
2017 Nakai K, Xia W, Liao HW, Saito M, Hung MC, Yamaguchi H. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer (Tokyo, Japan). PMID 28643125 DOI: 10.1007/s12282-017-0790-z  0.8
2017 Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, ... Hung MC, et al. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. American Journal of Cancer Research. 7: 657-672. PMID 28401019  0.96
2017 Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nature Communications. 8: 14437. PMID 28232723 DOI: 10.1038/ncomms14437  0.72
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2013 Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. Plos One. 8: e73406. PMID 24039934 DOI: 10.1371/journal.pone.0073406  0.92
2013 Shen J, Wang Y, Hung MC. RASAL2: wrestling in the combat of Ras activation. Cancer Cell. 24: 277-9. PMID 24029223 DOI: 10.1016/j.ccr.2013.08.024  0.68
2013 Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Research. 73: 6516-25. PMID 24014597 DOI: 10.1158/0008-5472.CAN-13-0967  0.92
2013 Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5901-13. PMID 23989979 DOI: 10.1158/1078-0432.CCR-12-3776  0.92
2013 Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154: 556-68. PMID 23911321 DOI: 10.1016/j.cell.2013.06.048  0.8
2013 Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. The Prostate. 73: 1453-61. PMID 23765757 DOI: 10.1002/pros.22692  0.84
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2013 Chen CT, Hung MC. Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. American Journal of Translational Research. 5: 393-403. PMID 23724163  0.96
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2013 Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. Plos One. 8: e61362. PMID 23593472 DOI: 10.1371/journal.pone.0061362  0.92
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2013 Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 23: 316-31. PMID 23453623 DOI: 10.1016/j.ccr.2013.01.022  0.92
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2013 Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Molecular Pharmacology. 83: 857-69. PMID 23355539 DOI: 10.1124/mol.112.082743  0.88
2013 Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MC. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 845-54. PMID 23344263 DOI: 10.1158/1078-0432.CCR-12-2621  0.92
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2013 Yang PW, Hung MC, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers in Medical Science. 28: 605-14. PMID 22585382 DOI: 10.1007/s10103-012-1119-y  0.68
2012 Ho TH, Monzon FA, Hoang A, Tamboli P, Furge KA, Dykema K, Petillo D, Teh BT, Tannir NM, Hung MC, Jonasch E. Regulation of SETD2, a histone methyltransferase, in advanced clear cell renal cell carcinoma (ccRCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 368. PMID 28143256 DOI: 10.1200/jco.2012.30.5_suppl.368  0.32
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2012 Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. The Journal of Biological Chemistry. 287: 31015-26. PMID 22815474 DOI: 10.1074/jbc.M112.358077  0.92
2012 Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W, Hung MC, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Molecular Cancer Therapeutics. 11: 1915-24. PMID 22752427 DOI: 10.1158/1535-7163.MCT-12-0191  0.92
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2012 Ouelaa-Benslama R, De Wever O, Hendrix A, Sabbah M, Lambein K, Land D, Prévost G, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C. Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition International Journal of Oncology. 41: 189-200. PMID 22552300 DOI: 10.3892/ijo.2012.1457  0.92
2012 Wang YN, Hung MC. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell & Bioscience. 2: 13. PMID 22520625 DOI: 10.1186/2045-3701-2-13  0.72
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2012 Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC. Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. Journal of Cellular Physiology. 227: 1446-54. PMID 21618535 DOI: 10.1002/jcp.22860  0.84
2011 Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, ... ... Hung MC, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of Clinical Investigation. 121: 4526-36. PMID 21985787 DOI: 10.1172/JCI45008  0.92
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2011 Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. European Journal of Pharmacology. 670: 96-104. PMID 21907193 DOI: 10.1016/j.ejphar.2011.08.006  0.52
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2010 Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M, Hung MC. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Research. 70: 5096-108. PMID 20501832 DOI: 10.1158/0008-5472.CAN-09-4148  1
2010 Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab On a Chip. 10: 1793-8. PMID 20498894 DOI: 10.1039/c002937h  0.92
2010 Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 70: 4709-18. PMID 20484037 DOI: 10.1158/0008-5472.CAN-09-4524  0.92
2010 Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Research. 70: 2424-34. PMID 20215498 DOI: 10.1158/0008-5472.CAN-09-0878  0.96
2010 Kuo HP, Hung MC. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? American Journal of Translational Research. 2: 56-64. PMID 20182582  1
2010 Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, ... ... Hung MC, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science Signaling. 3: ra9. PMID 20145209 DOI: 10.1126/scisignal.2000590  1
2009 Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, ... ... Hung MC, et al. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Molecular Cell. 36: 131-40. PMID 19818716 DOI: 10.1016/j.molcel.2009.07.025  1
2009 Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochemical and Biophysical Research Communications. 389: 640-4. PMID 19766100 DOI: 10.1016/j.bbrc.2009.09.042  1
2009 Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochemical and Biophysical Research Communications. 389: 156-61. PMID 19716809 DOI: 10.1016/j.bbrc.2009.08.127  1
2009 Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Molecular Carcinogenesis. 48: 1048-58. PMID 19526459 DOI: 10.1002/mc.20557  1
2009 Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 28: 2436-45. PMID 19448664 DOI: 10.1038/onc.2009.98  0.92
2009 Cheng X, Hung MC. Regulation of breast cancer metastasis by atypical chemokine receptors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2951-3. PMID 19383808 DOI: 10.1158/1078-0432.CCR-09-0141  1
2009 Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 752-7. PMID 19188143 DOI: 10.1158/1078-0432.CCR-08-0124  0.96
2008 Tsou PH, Chou CK, Saldana S, Hung MC, Kameoka J. The fabrication and testing of electrospun silica nanofiber membranes for the detection of proteins. Nanotechnology. 19: 445714. PMID 19081800 DOI: 10.1088/0957-4484/19/44/445714  0.92
2008 Lee DF, Kuo HP, Chen CT, Wei Y, Chou CK, Hung JY, Yen CJ, Hung MC. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. International Journal of Molecular Medicine. 22: 633-8. PMID 18949383 DOI: 10.3892/ijmm_00000065  0.92
2008 Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5656-62. PMID 18794072 DOI: 10.1158/1078-0432.CCR-08-0123  0.88
2008 Ding Q, Huo L, Yang JY, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, ... ... Hung MC, et al. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 68: 6109-17. PMID 18676833 DOI: 10.1158/0008-5472.CAN-08-0579  1
2008 Yen CJ, Izzo JG, Lee DF, Guha S, Wei Y, Wu TT, Chen CT, Kuo HP, Hsu JM, Sun HL, Chou CK, Buttar NS, Wang KK, Huang P, Ajani J, ... Hung MC, et al. Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. Cancer Research. 68: 2632-40. PMID 18413730 DOI: 10.1158/0008-5472.CAN-07-5460  1
2008 Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, ... ... Hung MC, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 10: 138-48. PMID 18204439 DOI: 10.1038/ncb1676  1
2007 Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle (Georgetown, Tex.). 6: 3011-4. PMID 18073529 DOI: 10.4161/cc.6.24.5085  0.88
2007 Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, Hsiao CD. Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Research. 35: 6984-94. PMID 17940099 DOI: 10.1093/nar/gkm703  0.96
2007 Cheng X, Hung MC. Breast cancer brain metastases. Cancer Metastasis Reviews. 26: 635-43. PMID 17717635 DOI: 10.1007/s10555-007-9083-x  1
2007 Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, ... ... Hung MC, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 130: 440-55. PMID 17693255 DOI: 10.1016/j.cell.2007.05.058  0.92
2007 Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, ... Hung MC, et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 12: 52-65. PMID 17613436 DOI: 10.1016/j.ccr.2007.05.009  1
2007 Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Research. 67: 4564-71. PMID 17495324 DOI: 10.1158/0008-5472.CAN-06-1788  0.96
2007 Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Molecular and Cellular Biology. 27: 4006-17. PMID 17387146 DOI: 10.1128/MCB.00620-06  0.96
2006 Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung MC. Tyrosine phosphorylation controls PCNA function through protein stability. Nature Cell Biology. 8: 1359-68. PMID 17115032 DOI: 10.1038/ncb1501  0.96
2006 Ping B, He X, Xia W, Lee DF, Wei Y, Yu D, Mills G, Shi D, Hung MC. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. International Journal of Oncology. 29: 1103-10. PMID 17016640  0.88
2006 Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation Molecular and Cellular Biology. 26: 7269-7282. PMID 16980628 DOI: 10.1128/MCB.00172-06  0.92
2006 Yu Z, Xia W, Wang HY, Wang SC, Pan Y, Kwong KY, Hortobagyi GN, Hung MC. Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. Molecular Carcinogenesis. 45: 667-75. PMID 16652376 DOI: 10.1002/mc.20212  0.92
2006 Day CP, Rau KM, Qiu L, Liu CW, Kuo HP, Xie X, Lopez-Berestein G, Hortobagyi GN, Hung MC. Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model. Cancer Gene Therapy. 13: 706-19. PMID 16514421 DOI: 10.1038/sj.cgt.7700945  1
2006 Chou CK, Hung JY, Liu JC, Chen CT, Hung MC. An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein. Cancer Gene Therapy. 13: 746-52. PMID 16410824 DOI: 10.1038/sj.cgt.7700927  0.92
2006 Ou-Yang F, Lan KL, Chen CT, Liu JC, Weng CL, Chou CK, Xie X, Hung JY, Wei Y, Hortobagyi GN, Hung MC. Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells. Cancer Research. 66: 378-84. PMID 16397252 DOI: 10.1158/0008-5472.CAN-05-1578  0.92
2006 Hanada N, Lo HW, Day CP, Pan Y, Nakajima Y, Hung MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis. 45: 10-7. PMID 16299810 DOI: 10.1002/mc.20147  0.8
2005 Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and Cellular Biology. 25: 11005-18. PMID 16314522 DOI: 10.1128/MCB.25.24.11005-11018.2005  0.88
2005 Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (New York, N.Y.). 310: 306-10. PMID 16224021 DOI: 10.1126/science.1118947  0.96
2005 Rau KM, Kang HY, Cha TL, Miller SA, Hung MC. The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers. Endocrine-Related Cancer. 12: 511-32. PMID 16172190 DOI: 10.1677/erc.1.01026  0.96
2005 Lo HW, Day CP, Hung MC. Cancer-Specific Gene Therapy Advances in Genetics. 54: 233-255. PMID 16096014 DOI: 10.1016/S0065-2660(05)54010-0  0.92
2005 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, ... Hung MC, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 19: 159-70. PMID 16039586 DOI: 10.1016/j.molcel.2005.06.009  0.96
2005 Shao R, Lee DF, Wen Y, Ding Y, Xia W, Ping B, Yagita H, Spohn B, Hung MC. E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation. Molecular Cancer Research : McR. 3: 219-26. PMID 15831675 DOI: 10.1158/1541-7786.MCR-04-0084  0.96
2005 Cha TL, Qiu L, Chen CT, Wen Y, Hung MC. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Research. 65: 2287-95. PMID 15781642 DOI: 10.1158/0008-5472.CAN-04-3250  0.96
2004 Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 64: 9080-5. PMID 15604276 DOI: 10.1158/0008-5472.CAN-04-2419  0.96
2004 Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 6: 459-69. PMID 15542430 DOI: 10.1016/j.ccr.2004.09.027  1
2004 Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 6: 251-61. PMID 15380516 DOI: 10.1016/j.ccr.2004.07.012  0.88
2004 Chen JS, Liu JC, Shen L, Rau KM, Kuo HP, Li YM, Shi D, Lee YC, Chang KJ, Hung MC. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Therapy. 11: 740-7. PMID 15359286 DOI: 10.1038/sj.cgt.7700752  1
2004 Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3815-24. PMID 15173090 DOI: 10.1158/1078-0432.CCR-03-0527  0.92
2004 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 117: 225-37. PMID 15084260  0.96
2004 Makino K, Day CP, Wang SC, Li YM, Hung MC. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene. 23: 3883-7. PMID 15021910 DOI: 10.1038/sj.onc.1207485  0.92
2004 Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Molecular Carcinogenesis. 39: 139-46. PMID 14991743 DOI: 10.1002/mc.10169  0.96
2004 Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 23: 1896-901. PMID 14981540 DOI: 10.1038/sj.onc.1207314  0.92
2003 Li YM, Wen Y, Zhou BP, Kuo HP, Ding Q, Hung MC. Enhancement of Bik antitumor effect by Bik mutants. Cancer Research. 63: 7630-3. PMID 14633680  1
2003 Lee WP, Tai DI, Tsai SL, Yeh CT, Chao Y, Lee SD, Hung MC. Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine. Cancer Research. 63: 6229-36. PMID 14559808  0.84
2003 Wen Y, Giri D, Yan DH, Spohn B, Zinner RG, Xia W, Thompson TC, Matusik RJ, Hung MC. Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Molecular Carcinogenesis. 37: 130-7. PMID 12884364 DOI: 10.1002/mc.10129  0.96
2002 Kwong KY, Zou Y, Day CP, Hung MC. The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Oncogene. 21: 8340-6. PMID 12447697 DOI: 10.1038/sj.onc.1206050  0.92
2002 Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell. 2: 323-34. PMID 12398896  0.96
2002 Ding Y, Wen Y, Spohn B, Wang L, Xia W, Kwong KY, Shao R, Li Z, Hortobagyi GN, Hung MC, Yan DH. Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 3290-7. PMID 12374701  0.92
2002 Meric F, Lee WP, Sahin A, Zhang H, Kung HJ, Hung MC. Expression profile of tyrosine kinases in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 361-7. PMID 11839650  0.84
2002 Lee WP, Wen Y, Varnum B, Hung MC. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. 21: 329-36. PMID 11821945 DOI: 10.1038/sj.onc.1205066  0.96
2002 Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC. Systemic tumor suppression by the proapoptotic gene bik. Cancer Research. 62: 8-12. PMID 11782349  0.96
2001 Wen Y, Yan DH, Wang B, Spohn B, Ding Y, Shao R, Zou Y, Xie K, Hung MC. p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Cancer Research. 61: 7142-7. PMID 11585747  0.96
2001 Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biology. 3: 802-8. PMID 11533659 DOI: 10.1038/ncb0901-802  0.92
2000 Wen Y, Hu MC, Makino K, Spohn B, Bartholomeusz G, Yan DH, Hung MC. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Research. 60: 6841-5. PMID 11156376  0.96
2000 Meric F, Liao Y, Lee WP, Pollock RE, Hung MC. Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 3832-6. PMID 11051226  0.84
2000 Xia W, Lau YK, Hu MC, Li L, Johnston DA, Sheng Sj, El-Naggar A, Hung MC. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. Oncogene. 19: 2398-403. PMID 10828881 DOI: 10.1038/sj.onc.1203535  0.8
2000 Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 97: 4262-6. PMID 10759547 DOI: 10.1073/pnas.060025397  0.92
2000 Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. The Journal of Biological Chemistry. 275: 8027-31. PMID 10713122  0.92
2000 Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine. 6: 189-95. PMID 10655108 DOI: 10.1038/72294  0.92
2000 Wen Y, Yan DH, Spohn B, Deng J, Lin SY, Hung MC. Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells. Cancer Research. 60: 42-6. PMID 10646849  0.96
1999 Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, Liu AR, Li L, Katz RL, Hung MC. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 4164-74. PMID 10632356  0.8
1999 Lee WP, Liao Y, Robinson D, Kung HJ, Liu ET, Hung MC. Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Molecular and Cellular Biology. 19: 8075-82. PMID 10567533  0.84
1999 Hung MC, Lau YK. Basic science of HER-2/neu: A review Seminars in Oncology. 26: 51-59. PMID 10482194  0.92
1999 Zhang L, Lau YK, Xia W, Hortobagyi GN, Hung MC. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 343-53. PMID 10037184  0.8
1999 Yan DH, Wen Y, Spohn B, Choubey D, Gutterman JU, Hung MC. Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202. Oncogene. 18: 807-11. PMID 9989832 DOI: 10.1038/sj.onc.1202369  0.96
1998 Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung MC. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene. 16: 2855-63. PMID 9671406 DOI: 10.1038/sj.onc.1201813  0.72
1997 Xia W, Lau YK, Zhang HZ, Liu AR, Li L, Kiyokawa N, Clayman GL, Katz RL, Hung MC. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 3: 3-9. PMID 9815530  0.8
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