Mien-Chie Hung - Publications

Affiliations: 
The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Oncology, Molecular Biology, Biomedical Engineering

297 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. The Journal of Cell Biology. PMID 31387940 DOI: 10.1083/jcb.201901156  0.84
2019 Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Wei Y, Chou CK, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, ... ... Hung MC, et al. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Cancer Cell. PMID 31327656 DOI: 10.1016/j.ccell.2019.06.008  0.84
2019 Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, ... ... Hung MC, et al. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. The Journal of Clinical Investigation. 130. PMID 31305264 DOI: 10.1172/JCI126022  0.84
2019 Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, ... ... Hung MC, et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology. PMID 31160797 DOI: 10.1038/s41590-019-0400-7  0.84
2019 Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J, Hung MC. HOinduces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bounded retrograde trafficking mechanism. The Journal of Biological Chemistry. PMID 30962283 DOI: 10.1074/jbc.RA118.005953  0.76
2019 Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX, Nie L, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD, Hung MC. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. American Journal of Cancer Research. 9: 608-618. PMID 30949414  0.84
2019 Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, ... ... Hung MC, et al. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. PMID 30902885 DOI: 10.1136/gutjnl-2019-318419  0.76
2019 Lee HH, Wang YN, Hung MC. Functional roles of the human ribonuclease a superfamily in RNA metabolism and membrane receptor biology. Molecular Aspects of Medicine. PMID 30902663 DOI: 10.1016/j.mam.2019.03.003  0.76
2019 Lu S, Han Z, Hung MC, Xu J, Xu Y, Zheng P, Zheng ZM, Zou L, Li Z, Zheng L, Kang Y, Yang Y, He L, Liao XC, Yu H, et al. Racial profiling harms science. Science (New York, N.Y.). 363: 1290-1292. PMID 30898924 DOI: 10.1126/science.aaw6854  0.72
2019 Liu YL, Chou CK, Kim M, Vasisht R, Kuo YA, Ang P, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov TE, Hung MC, et al. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Scientific Reports. 9: 3395. PMID 30833579 DOI: 10.1038/s41598-018-37625-0  0.76
2019 Wang WJ, Hsu JM, Wang YN, Lee HH, Yamaguchi H, Liao HW, Hung MC. An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5. American Journal of Cancer Research. 9: 180-185. PMID 30755821  0.76
2019 Wang EM, Akasaka H, Zhao J, Varadhachary GR, Lee JE, Maitra A, Fleming JB, Hung MC, Wang H, Katz MHG. Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma. Pancreas. PMID 30747823 DOI: 10.1097/MPA.0000000000001248  0.48
2019 Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. The Journal of Clinical Investigation. PMID 30741721 DOI: 10.1172/JCI121987  0.72
2019 Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Billalabeitia EG, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nature Communications. 10: 636. PMID 30733438 DOI: 10.1038/s41467-019-08481-x  0.84
2019 Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, ... ... Hung MC, et al. MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology. PMID 30711629 DOI: 10.1053/j.gastro.2019.01.252  0.84
2019 Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, ... ... Hung MC, et al. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Research. PMID 30631154 DOI: 10.1038/s41422-018-0134-3  0.72
2018 Dong Q, Du Y, Li H, Liu C, Wei Y, Chen MK, Zhao X, Chu YY, Qiu Y, Qin L, Yamaguchi H, Hung MC. EGFR and c-MET cooperate to enhance resistance to PARP inhibitors in hepatocellular carcinoma. Cancer Research. PMID 30573522 DOI: 10.1158/0008-5472.CAN-18-1273  0.8
2018 Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, ... ... Hung MC, et al. Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 34: 954-969.e4. PMID 30537515 DOI: 10.1016/j.ccell.2018.11.007  0.96
2018 Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, et al. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. Journal of the National Cancer Institute. PMID 30534944 DOI: 10.1093/jnci/djy160  0.52
2018 Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y, Hung MC. Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Cell Research. PMID 30514902 DOI: 10.1038/s41422-018-0124-5  0.84
2018 Wang YN, Lee HH, Hung MC. A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases. Journal of Biomedical Science. 25: 83. PMID 30449278 DOI: 10.1186/s12929-018-0484-7  0.76
2018 Hsu JM, Li CW, Lai YJ, Hung MC. Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy. Cancer Research. 78: 6349-6353. PMID 30442814 DOI: 10.1158/0008-5472.CAN-18-1892  0.76
2018 Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X, Hung MC, Lin X. Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. The Journal of Biological Chemistry. PMID 30361438 DOI: 10.1074/jbc.RA118.005449  0.72
2018 Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, et al. Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Science Translational Medicine. 10. PMID 30355799 DOI: 10.1126/scitranslmed.aat3487  0.48
2018 Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, ... ... Hung MC, et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nature Genetics. PMID 30349115 DOI: 10.1038/s41588-018-0252-3  0.72
2018 Yam C, Hung MC, Hortobagyi GN. CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line? Oncotarget. 9: 34193-34195. PMID 30344934 DOI: 10.18632/oncotarget.26134  0.84
2018 Shao B, Li CW, Lim SO, Sun L, Lai YJ, Hou J, Liu C, Chang CW, Qiu Y, Hsu JM, Chan LC, Zha Z, Li H, Hung MC. Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. American Journal of Cancer Research. 8: 1837-1846. PMID 30323975  0.76
2018 Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W, Xia W, Rao PH, Zhao R, Hung MC, et al. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Research. 33: 36-40. PMID 30312871 DOI: 10.1016/j.scr.2018.10.003  0.88
2018 Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung MC, Lin X. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 49: 504-514.e4. PMID 30231984 DOI: 10.1016/j.immuni.2018.08.018  0.72
2018 Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nature Cell Biology. PMID 30202049 DOI: 10.1038/s41556-018-0178-0  0.8
2018 Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, ... ... Hung MC, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Molecular Cell. 71: 606-620.e7. PMID 30118680 DOI: 10.1016/j.molcel.2018.07.030  0.84
2018 Sun LL, Yang RY, Li CW, Chen MK, Shao B, Hsu JM, Chan LC, Yang Y, Hsu JL, Lai YJ, Hung MC. Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. American Journal of Cancer Research. 8: 1307-1316. PMID 30094103  0.76
2018 Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Mutant LKB1 confers enhanced radiosensitization in combination with trametinib in KRAS-mutant non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30068711 DOI: 10.1158/1078-0432.CCR-18-1489  0.72
2018 Li CW, Lai YJ, Hsu JL, Hung MC. Activation of phagocytosis by immune checkpoint blockade. Frontiers of Medicine. PMID 30062558 DOI: 10.1007/s11684-018-0657-5  0.76
2018 Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, ... ... Hung MC, et al. Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. Cancer Research. PMID 29967256 DOI: 10.1158/0008-5472.CAN-17-0385  0.68
2018 Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, Hung MC. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Research. PMID 29959401 DOI: 10.1038/s41422-018-0060-4  0.84
2018 Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC. A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues. Biosensors & Bioelectronics. 117: 97-103. PMID 29890396 DOI: 10.1016/j.bios.2018.05.053  0.8
2018 Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC. Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression. Cancer Research. PMID 29789418 DOI: 10.1158/0008-5472.CAN-18-0040  0.84
2018 Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, ... ... Hung MC, et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nature Communications. 9: 1908. PMID 29765039 DOI: 10.1038/s41467-018-04313-6  0.92
2018 Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, ... Hung MC, et al. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Research. 29: 215-219. PMID 29730572 DOI: 10.1016/j.scr.2018.04.013  0.88
2018 Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, ... ... Hung MC, et al. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports. 23: 823-837. PMID 29669287 DOI: 10.1016/j.celrep.2018.03.078  1
2018 Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY, Hung MC. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. American Journal of Cancer Research. 8: 514-525. PMID 29637005  0.8
2018 Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, ... ... Hung MC, et al. Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. Cancer Cell. PMID 29606349 DOI: 10.1016/j.ccell.2018.02.012  0.92
2018 Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, ... ... Hung MC, et al. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 33: 187-201.e10. PMID 29438695 DOI: 10.1016/j.ccell.2018.01.009  0.84
2018 Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. American Journal of Cancer Research. 8: 183-191. PMID 29416931  0.56
2018 Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, et al. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Research. 27: 131-135. PMID 29414603 DOI: 10.1016/j.scr.2018.01.035  0.88
2018 Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, ... ... Hung MC, et al. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Molecular Cell. 69: 279-291.e5. PMID 29351847 DOI: 10.1016/j.molcel.2017.12.024  0.84
2017 Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S. Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. American Journal of Cancer Research. 7: 2587-2599. PMID 29312811  0.76
2017 Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. The Journal of Clinical Investigation. PMID 29251629 DOI: 10.1172/JCI89212  0.72
2017 Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robotics. 4: 390-399. PMID 29251562 DOI: 10.1089/soro.2016.0073  0.92
2017 Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 7: 4805-4824. PMID 29187905 DOI: 10.7150/thno.20771  0.72
2017 Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis. Hepatology (Baltimore, Md.). PMID 29171033 DOI: 10.1002/hep.29678  0.8
2017 Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, ... Hung MC, et al. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. The Journal of Clinical Investigation. PMID 29130936 DOI: 10.1172/JCI91553  0.84
2017 Li CW, Lim SO, Hsu JL, Hung MC. Rational combination of immunotherapy for triple negative breast cancer treatment. Chinese Clinical Oncology. 6: 54. PMID 29129094 DOI: :10.21037/cco.2017.08.04  0.76
2017 Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, ... ... Hung MC, et al. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Science Translational Medicine. 9. PMID 29118262 DOI: 10.1126/scitranslmed.aao4307  0.76
2017 Liao HW, Hung MC. Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model. Bio-Protocol. 7. PMID 29104894 DOI: 10.21769/BioProtoc.2311  0.44
2017 Yang R, Hung MC. The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Science China. Life Sciences. PMID 29027155 DOI: 10.1007/s11427-017-9176-7  0.48
2017 Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Molecular Cell. 67: 733-743.e4. PMID 28844863 DOI: 10.1016/j.molcel.2017.07.026  0.76
2017 Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Martinez FP, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Molecular and Cellular Biology. PMID 28760776 DOI: 10.1128/MCB.00142-17  0.36
2017 Nakai K, Xia W, Liao HW, Saito M, Hung MC, Yamaguchi H. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer (Tokyo, Japan). PMID 28643125 DOI: 10.1007/s12282-017-0790-z  0.84
2017 Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, ... Hung MC, et al. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. American Journal of Cancer Research. 7: 657-672. PMID 28401019  0.92
2017 Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nature Communications. 8: 14437. PMID 28232723 DOI: 10.1038/ncomms14437  0.68
2017 Hu J, Bernatchez C, Zhang L, Xia X, Kleinerman ES, Hung MC, Hwu P, Li S. Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases. Cancer Immunology Research. PMID 28223282 DOI: 10.1158/2326-6066.CIR-16-0234  0.6
2017 Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, ... Hung MC, et al. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nature Cell Biology. PMID 28218907 DOI: 10.1038/ncb3473  0.68
2017 Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. International Journal of Cancer. PMID 28214331 DOI: 10.1002/ijc.30658  0.72
2017 Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, et al. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28196873 DOI: 10.1158/1078-0432.CCR-16-1955  0.68
2017 Jiao S, Xia W, Yamaguchi H, Wei Y, Chen MK, Hsu JM, Hsu JL, Yu WH, Du Y, Lee HH, Li CW, Chou CK, Lim SO, Chang SS, Litton JK, ... ... Hung MC, et al. PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28167507 DOI: 10.1158/1078-0432.CCR-16-3215  0.84
2017 Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, González-Billalabeitia E, Hung MC, Song SJ, Song MS. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. PMID 28162974 DOI: 10.1016/j.ccell.2017.01.003  0.84
2017 Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer. Annals of Surgical Oncology. PMID 28160139 DOI: 10.1245/s10434-017-5769-7  0.76
2017 Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, ... Hung MC, et al. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nature Cell Biology. PMID 28114269 DOI: 10.1038/ncb3464  0.68
2017 Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nature Medicine. PMID 28112734 DOI: 10.1038/nm.4260  0.72
2017 Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, ... ... Hung MC, et al. Metastasis regulation by PPARD expression in cancer cells. Jci Insight. 2: e91419. PMID 28097239 DOI: 10.1172/jci.insight.91419  0.52
2016 Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH, Hung MC, Hung SC. Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nature Communications. 7: 14027. PMID 28004659 DOI: 10.1038/ncomms14027  0.68
2016 Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, et al. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. PMID 27918549 DOI: 10.1038/ncb3445  0.56
2016 Hsu JL, Hung MC. The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer. Cancer Metastasis Reviews. PMID 27913999 DOI: 10.1007/s10555-016-9649-6  0.76
2016 Long Y, Tsai WB, Wang D, Hawke DH, Savaraj N, Feun LG, Hung MC, Chen HH, Kuo MT. Argininosuccinate Synthetase 1 (ASS1) Is a Common Metabolic Marker of Chemosensitivity for Targeted Arginine- and Glutamine-Starvation Therapy. Cancer Letters. PMID 27913198 DOI: 10.1016/j.canlet.2016.11.028  0.76
2016 Lim SO, Li CW, Xia W, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, ... ... Hung MC, et al. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. PMID 27866850 DOI: 10.1016/j.ccell.2016.10.010  0.84
2016 Liu YL, Perillo EP, Liu C, Yu P, Chou CK, Hung MC, Dunn AK, Yeh HC. Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking. Biophysical Journal. 111: 2214-2227. PMID 27851944 DOI: 10.1016/j.bpj.2016.09.041  0.76
2016 Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, ... ... Hung MC, et al. ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. Cancer Cell. 30: 723-736. PMID 27846390 DOI: 10.1016/j.ccell.2016.10.001  0.32
2016 Wang Y, Hsu JM, Kang Y, Wei Y, Lee PC, Chang SJ, Hsu YH, Hsu JL, Wang HL, Chang WC, Li CW, Liao HW, Chang SS, Xia W, Ko HW, ... ... Hung MC, et al. Oncogenic functions of Gli in pancreatic adenocarcinoma are supported by its PRMT1-mediated methylation. Cancer Research. PMID 27758883 DOI: 10.1158/0008-5472.CAN-16-0715  0.84
2016 Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, et al. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Science Advances. 2: e1501290. PMID 27757426 DOI: 10.1126/sciadv.1501290  0.44
2016 Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, ... ... Hung MC, et al. Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nature Medicine. 22: 1192. PMID 27711065 DOI: 10.1038/nm1016-1192c  0.92
2016 Nakai K, Hung MC, Yamaguchi H. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. American Journal of Cancer Research. 6: 1609-1623. PMID 27648353  0.56
2016 Hung MC, Yang R, Sun Y. Powering Tumor Metastasis with Recycled Fuel. Cancer Cell. 30: 374-375. PMID 27622330 DOI: 10.1016/j.ccell.2016.08.014  0.48
2016 Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, ... ... Hung MC, et al. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature Communications. 7: 12632. PMID 27572267 DOI: 10.1038/ncomms12632  0.64
2016 Lee CJ, Hsu LS, Yue CH, Lin H, Chiu YW, Lin YY, Huang CY, Hung MC, Liu JY. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells. Oncotarget. PMID 27542222 DOI: 10.18632/oncotarget.11337  0.76
2016 Chen CK, Yu WH, Cheng TY, Chen MW, Su CY, Yang YC, Kuo TC, Lin MT, Huang YC, Hsiao M, Hua KT, Hung MC, Kuo ML. Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis. Scientific Reports. 6: 31398. PMID 27507763 DOI: 10.1038/srep31398  0.64
2016 Ko HW, Lee HH, Huo L, Xia W, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW, Lim SO, Li CW, Wei Y, ... ... Hung MC, et al. GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. PMID 27494834 DOI: 10.18632/oncotarget.11008  0.64
2016 Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH, Hung MC, Hung SC. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nature Communications. 7: 11798. PMID 27306323 DOI: 10.1038/ncomms11798  0.84
2016 Rojas A, Zhang P, Wang Y, Foo WC, Muñoz NM, Xiao L, Wang J, Gores GJ, Hung MC, Blechacz B. A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. Neoplasia (New York, N.Y.). 18: 371-86. PMID 27292026 DOI: 10.1016/j.neo.2016.04.002  0.72
2016 Chen YH, Chung CC, Liu YC, Yeh SP, Hsu JL, Hung MC, Su HL, Li LY. EZH2 and HDAC9c regulate age-dependent mesenchymal stem cell differentiation into osteoblasts and adipocytes. Stem Cells (Dayton, Ohio). PMID 27250566 DOI: 10.1002/stem.2400  0.6
2016 Chang TY, Chen HA, Chiu CF, Chang YW, Kuo TC, Tseng PC, Wang W, Hung MC, Su JL. Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL. Cancer Research. PMID 27216190 DOI: 10.1158/0008-5472.CAN-15-2555  0.6
2016 Chen MK, Hung MC. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. American Journal of Cancer Research. 6: 827-42. PMID 27186434  0.64
2016 Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. American Journal of Cancer Research. 6: 628-38. PMID 27152240  0.76
2016 Chang CC, Zhang C, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P, Hung MC, Behbod F, Yu D. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. PMID 27150057 DOI: 10.18632/oncotarget.9136  0.76
2016 Yao J, Caballero OL, Huang Y, Lin C, Rimoldi D, Behren A, Cebon JS, Hung MC, Weinstein JN, Strausberg RL, Zhao Q. Altered expression and splicing of ESRP1 in malignant melanoma correlates with epithelial-mesenchymal status and tumor-associated immune cytolytic activity. Cancer Immunology Research. PMID 27045022 DOI: 10.1158/2326-6066.CIR-15-0255  0.68
2016 Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, ... ... Hung MC, et al. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications. 7: 11169. PMID 27041221 DOI: 10.1038/ncomms11169  0.36
2016 Chou CK, Tsou PH, Hsu JL, Lee HH, Wang YN, Kameoka J, Hung MC. Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. 114: 20.11.1-20.11.22. PMID 27038387 DOI: 10.1002/0471142727.mb2011s114  0.76
2016 Chou CK, Fan CC, Lin PS, Liao PY, Tung JC, Hsieh CH, Hung MC, Chen CH, Chang WC. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Oncotarget. PMID 27013588 DOI: 10.18632/oncotarget.8264  0.68
2016 Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW, Hung MC, et al. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nature Communications. 7: 10180. PMID 26782714 DOI: 10.1038/ncomms10180  0.36
2016 Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, ... ... Hung MC, et al. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nature Medicine. PMID 26779812 DOI: 10.1038/nm.4032  0.44
2016 Lim SO, Li CW, Xia W, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, ... ... Hung MC, et al. EGFR signaling enhances aerobic glycolysis in triple negative breast cancer cells to promote tumor growth and immune escape. Cancer Research. PMID 26759242 DOI: 10.1158/0008-5472.CAN-15-2478  0.84
2016 Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, ... ... Hung MC, et al. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation. Cancer Research. PMID 26759241 DOI: 10.1158/0008-5472.CAN-15-1941  0.84
2016 Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, ... ... Hung MC, et al. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nature Cell Biology. PMID 26751287 DOI: 10.1038/ncb3295  0.48
2016 Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. PMID 26747897 DOI: 10.1158/0008-5472.CAN-15-0906  0.68
2015 Rahal OM, Nie L, Chan LC, Li CW, Hsu YH, Hsu J, Yu D, Hung MC. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. American Journal of Cancer Research. 5: 3624-34. PMID 26885451  0.84
2015 Chen CT, Chen YC, Yamaguchi H, Hung MC. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. American Journal of Cancer Research. 5: 3560-9. PMID 26885446  0.92
2015 Lukianova-Hleb EY, Kim YS, Aryasomayajula B, Boulikas T, Phan J, Hung MC, Torchilin VP, O'Neill BE, Lapotko DO. Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model. American Journal of Cancer Research. 5: 3534-47. PMID 26885444  0.84
2015 Lee HH, Wang YN, Hung MC. Non-canonical signaling mode of the epidermal growth factor receptor family. American Journal of Cancer Research. 5: 2944-58. PMID 26693051  0.76
2015 Wu TJ, Chang SS, Li CW, Hsu YH, Chen TC, Lee WC, Yeh CT, Hung MC. Severe hepatitis promotes hepatocellular carcinoma recurrence via NF-κB pathway-mediated epithelial-mesenchymal transition after resection. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26655845 DOI: 10.1158/1078-0432.CCR-15-0780  0.56
2015 Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, ... ... Hung MC, et al. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. The Journal of Clinical Investigation. PMID 26571401 DOI: 10.1172/JCI82826  0.84
2015 Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, Zhang X, Li N, Bose S, Wang Q, Sakkiah S, Abrol R, Jensen TW, Berman BP, Tanaka H, ... ... Hung MC, et al. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Reports. 13: 1046-1058. PMID 26565916 DOI: 10.1016/j.celrep.2015.09.063  0.84
2015 Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, ... ... Hung MC, et al. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. PMID 26481148 DOI: 10.1016/j.ccell.2015.09.008  0.84
2015 Yang PW, Chiang TH, Hsieh CY, Huang YC, Wong LF, Hung MC, Tsai JC, Lee JM. The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells. Lasers in Medical Science. PMID 26450615 DOI: 10.1007/s10103-015-1812-8  0.84
2015 Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nature Communications. 6: 8419. PMID 26420673 DOI: 10.1038/ncomms9419  0.84
2015 Chen WS, Yen CJ, Chen YJ, Chen JY, Wang LY, Chiu SJ, Shih WL, Ho CY, Wei TT, Pan HL, Chien PH, Hung MC, Chen CC, Huang WC. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget. PMID 26296971  0.8
2015 Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, ... ... Hung MC, et al. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. American Journal of Translational Research. 7: 1009-20. PMID 26279746  0.84
2015 Dai HY, Chen HY, Lai WC, Hung MC, Li LY. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. 6: 23807-19. PMID 26247632  0.8
2015 Perillo EP, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nature Communications. 6: 7874. PMID 26219252 DOI: 10.1038/ncomms8874  0.84
2015 Chen MK, Hung MC. Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. The Febs Journal. PMID 26096795 DOI: 10.1111/febs.13342  0.64
2015 Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, ... ... Hung MC, et al. The ZNF304-integrin axis protects against anoikis in cancer. Nature Communications. 6: 7351. PMID 26081979 DOI: 10.1038/ncomms8351  0.84
2015 Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Proteasome inhibition enhances the killing effect of BikDD gene therapy. American Journal of Translational Research. 7: 319-27. PMID 25901200  0.84
2015 Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Research. 75: 1846-58. PMID 25877877 DOI: 10.1158/0008-5472.CAN-14-2718  0.8
2015 Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 161: 240-54. PMID 25860607 DOI: 10.1016/j.cell.2015.02.045  0.84
2015 Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2580-90. PMID 25739674 DOI: 10.1158/1078-0432.CCR-14-2191  0.84
2015 Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, ... Hung MC, et al. 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 27: 177-92. PMID 25670079 DOI: 10.1016/j.ccell.2014.11.025  0.6
2015 Shen J, Hung MC. Signaling-mediated regulation of MicroRNA processing. Cancer Research. 75: 783-91. PMID 25660948 DOI: 10.1158/0008-5472.CAN-14-2568  0.48
2015 Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, ... Hung MC, et al. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Research. 25: 225-36. PMID 25601159 DOI: 10.1038/cr.2015.8  0.56
2015 Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, et al. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Molecular Oncology. 9: 586-600. PMID 25435280 DOI: 10.1016/j.molonc.2014.10.011  0.84
2015 Wang YN, Huo L, Hsu JL, Hung MC. Biochemical fractionation of membrane receptors in the nucleus. Methods in Molecular Biology (Clifton, N.J.). 1234: 99-112. PMID 25304351 DOI: 10.1007/978-1-4939-1755-6_9  0.84
2015 Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer. Annals of Surgical Oncology. 22: 889-98. PMID 25212833 DOI: 10.1245/s10434-014-4061-3  0.84
2014 Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, ... ... Hung MC, et al. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. American Journal of Translational Research. 6: 649-63. PMID 25628777  0.84
2014 Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 159: 1110-25. PMID 25416949 DOI: 10.1016/j.cell.2014.10.013  0.8
2014 Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT, Hung MC, Wu CH, Huang MT, Su JL. De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Oncotarget. 5: 10558-70. PMID 25301734  0.84
2014 Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH, Hung MC, Hsu NW, Shiah SG, Hsu NY, Su JL. miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression. Cancer Research. 74: 6280-90. PMID 25205106 DOI: 10.1158/0008-5472.CAN-14-0524  0.84
2014 Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, ... ... Hung MC, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nature Cell Biology. 16: 864-75. PMID 25086746 DOI: 10.1038/ncb3013  0.8
2014 Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y, Xia W, Yu D, Hung MC. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. American Journal of Translational Research. 6: 361-76. PMID 25075253  0.84
2014 Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Science Signaling. 7: ra71. PMID 25074979 DOI: 10.1126/scisignal.2005076  0.84
2014 Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, ... ... Hung MC, et al. EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Developmental Cell. 30: 224-37. PMID 25073158 DOI: 10.1016/j.devcel.2014.06.008  0.84
2014 Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Research. 74: 5229-43. PMID 25060522 DOI: 10.1158/0008-5472.CAN-13-2995  0.76
2014 Debeb BG, Gong Y, Atkinson RL, Sneige N, Huo L, Gonzalez-Angulo AM, Hung MC, Valero V, Ueno NT, Woodward WA. EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. Journal of Experimental & Clinical Cancer Research : Cr. 33: 58. PMID 25051981 DOI: 10.1186/s13046-014-0058-9  0.84
2014 Yamaguchi H, Hung MC. Regulation and Role of EZH2 in Cancer. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 46: 209-22. PMID 25038756 DOI: 10.4143/crt.2014.46.3.209  0.56
2014 Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, ... ... Hung MC, et al. Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Research. 74: 4822-35. PMID 24970481 DOI: 10.1158/0008-5472.CAN-14-0584  0.84
2014 Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. The Journal of Clinical Investigation. 124: 3093-106. PMID 24911147 DOI: 10.1172/JCI73351  0.84
2014 Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, ... Hung MC, et al. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Research. 74: 4170-82. PMID 24906622 DOI: 10.1158/0008-5472.CAN-13-3569  0.84
2014 Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, ... ... Hung MC, et al. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Molecular Cell. 54: 960-74. PMID 24857548 DOI: 10.1016/j.molcel.2014.04.024  0.84
2014 Xie X, Kong Y, Tang H, Yang L, Hsu JL, Hung MC. Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells. Molecular Cancer Therapeutics. 13: 1813-25. PMID 24785255 DOI: 10.1158/1535-7163.MCT-13-1004  0.84
2014 Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, ... ... Hung MC, et al. IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nature Communications. 5: 3661. PMID 24739462 DOI: 10.1038/ncomms4661  0.84
2014 Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MC. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Science Signaling. 7: rs1. PMID 24595109 DOI: 10.1126/scisignal.2004620  0.84
2014 Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. Plos Genetics. 10: e1004177. PMID 24586203 DOI: 10.1371/journal.pgen.1004177  0.72
2014 Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-Cell-Printing for live single-cell printing. Proceedings of the National Academy of Sciences of the United States of America. 111: 2948-53. PMID 24516129 DOI: 10.1073/pnas.1313661111  0.76
2014 Chang YW, Hung MC, Su JL. The anti-tumor activity of E1A and its implications in cancer therapy. Archivum Immunologiae Et Therapiae Experimentalis. 62: 195-204. PMID 24504082 DOI: 10.1007/s00005-014-0273-2  0.72
2014 Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. The Journal of Clinical Investigation. 124: 564-79. PMID 24382352 DOI: 10.1172/JCI71104  0.8
2014 Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Molecular Carcinogenesis. 53: 1011-26. PMID 24000122 DOI: 10.1002/mc.22068  0.84
2014 Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 33: 756-70. PMID 23376851 DOI: 10.1038/onc.2013.1  0.84
2013 Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, ... ... Hung MC, et al. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma. Molecular Cell. 52: 693-706. PMID 24332177 DOI: 10.1016/j.molcel.2013.11.009  0.84
2013 Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology. 15: 1486-94. PMID 24270891 DOI: 10.1038/ncb2874  0.8
2013 Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, ... ... Hung MC, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. The Journal of Clinical Investigation. 123: 5231-46. PMID 24200691 DOI: 10.1172/JCI68642  0.8
2013 Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. Plos One. 8: e73406. PMID 24039934 DOI: 10.1371/journal.pone.0073406  0.84
2013 Shen J, Wang Y, Hung MC. RASAL2: wrestling in the combat of Ras activation. Cancer Cell. 24: 277-9. PMID 24029223 DOI: 10.1016/j.ccr.2013.08.024  0.72
2013 Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Research. 73: 6516-25. PMID 24014597 DOI: 10.1158/0008-5472.CAN-13-0967  0.84
2013 Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5901-13. PMID 23989979 DOI: 10.1158/1078-0432.CCR-12-3776  0.84
2013 Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154: 556-68. PMID 23911321 DOI: 10.1016/j.cell.2013.06.048  0.64
2013 Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. The Prostate. 73: 1453-61. PMID 23765757 DOI: 10.1002/pros.22692  0.8
2013 Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, ... ... Hung MC, et al. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 23: 796-810. PMID 23764002 DOI: 10.1016/j.ccr.2013.04.027  0.84
2013 Huang WC, Hsu SC, Huang SJ, Chen YJ, Hsiao YC, Zhang W, Fidler IJ, Hung MC. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. American Journal of Translational Research. 5: 441-9. PMID 23724167  0.8
2013 Chen CT, Hung MC. Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. American Journal of Translational Research. 5: 393-403. PMID 23724163  0.92
2013 Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, ... ... Hung MC, et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature. 497: 383-7. PMID 23636329 DOI: 10.1038/nature12080  0.84
2013 Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. Plos One. 8: e61362. PMID 23593472 DOI: 10.1371/journal.pone.0061362  0.84
2013 Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, ... Hung MC, et al. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. Embo Molecular Medicine. 5: 531-47. PMID 23526793 DOI: 10.1002/emmm.201201783  0.84
2013 Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 23: 316-31. PMID 23453623 DOI: 10.1016/j.ccr.2013.01.022  0.72
2013 Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes & Development. 27: 274-87. PMID 23388826 DOI: 10.1101/gad.203760.112  0.84
2013 Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Molecular Pharmacology. 83: 857-69. PMID 23355539 DOI: 10.1124/mol.112.082743  0.8
2013 Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MC. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 845-54. PMID 23344263 DOI: 10.1158/1078-0432.CCR-12-2621  0.84
2013 Huang WC, Hung MC. Beyond NF-κB activation: nuclear functions of IκB kinase α. Journal of Biomedical Science. 20: 3. PMID 23343355 DOI: 10.1186/1423-0127-20-3  0.8
2013 Liu CM, Hsieh CL, He YC, Lo SJ, Liang JA, Hsieh TF, Josson S, Chung LW, Hung MC, Sung SY. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. Plos One. 8: e53795. PMID 23342005 DOI: 10.1371/journal.pone.0053795  0.56
2013 Lin SP, Lee YT, Yang SH, Miller SA, Chiou SH, Hung MC, Hung SC. Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. Cancer Letters. 328: 226-34. PMID 23017941 DOI: 10.1016/j.canlet.2012.08.036  0.84
2013 Yang PW, Hung MC, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers in Medical Science. 28: 605-14. PMID 22585382 DOI: 10.1007/s10103-012-1119-y  0.64
2012 Hong S, Tsou PH, Chou CK, Yamaguchi H, Su CB, Hung MC, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 6: 24132. PMID 23785388 DOI: 10.1063/1.4730332  0.84
2012 Lin SP, Lee YT, Wang JY, Miller SA, Chiou SH, Hung MC, Hung SC. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. Plos One. 7: e49605. PMID 23185379 DOI: 10.1371/journal.pone.0049605  0.84
2012 Chen YH, Hung MC, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. American Journal of Translational Research. 4: 364-75. PMID 23145205  0.8
2012 Chen PS, Su JL, Hung MC. Dysregulation of microRNAs in cancer. Journal of Biomedical Science. 19: 90. PMID 23075324 DOI: 10.1186/1423-0127-19-90  0.68
2012 Li L, Xie X, Luo J, Liu M, Xi S, Guo J, Kong Y, Wu M, Gao J, Xie Z, Tang J, Wang X, Wei W, Yang M, Hung MC, et al. Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2326-34. PMID 23032974 DOI: 10.1038/mt.2012.201  0.72
2012 Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine. 18: 1511-7. PMID 23001183 DOI: 10.1038/nm.2940  0.8
2012 Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, ... ... Hung MC, et al. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 11: 179-94. PMID 22862944 DOI: 10.1016/j.stem.2012.05.020  0.84
2012 Hung MC. On mammary gland growth factors: roles in normal development and in cancer Cold Spring Harbor Perspectives in Biology. 4. PMID 22855727 DOI: 10.1101/cshperspect.a013532  0.84
2012 Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Molecular Cancer Therapeutics. 11: 2212-21. PMID 22826466 DOI: 10.1158/1535-7163.MCT-12-0180  0.96
2012 Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. The Journal of Biological Chemistry. 287: 31015-26. PMID 22815474 DOI: 10.1074/jbc.M112.358077  0.84
2012 Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W, Hung MC, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Molecular Cancer Therapeutics. 11: 1915-24. PMID 22752427 DOI: 10.1158/1535-7163.MCT-12-0191  0.84
2012 Yamaguchi H, Hsu JL, Hung MC. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Frontiers in Oncology. 2: 15. PMID 22649777 DOI: 10.3389/fonc.2012.00015  0.84
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149: 1098-111. PMID 22632973 DOI: 10.1016/j.cell.2012.02.065  0.84
2012 Nie L, Wu HJ, Hsu JM, Chang SS, Labaff AM, Li CW, Wang Y, Hsu JL, Hung MC. Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. American Journal of Translational Research. 4: 127-50. PMID 22611467  0.84
2012 Ouelaa-Benslama R, De Wever O, Hendrix A, Sabbah M, Lambein K, Land D, Prévost G, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C. Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition International Journal of Oncology. 41: 189-200. PMID 22552300 DOI: 10.3892/ijo.2012.1457  0.84
2012 Wang YN, Hung MC. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell & Bioscience. 2: 13. PMID 22520625 DOI: 10.1186/2045-3701-2-13  0.76
2012 Wang YN, Lee HH, Lee HJ, Du Y, Yamaguchi H, Hung MC. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. The Journal of Biological Chemistry. 287: 16869-79. PMID 22451678 DOI: 10.1074/jbc.M111.314799  0.76
2012 Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, ... ... Hung MC, et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 21: 374-87. PMID 22439934 DOI: 10.1016/j.ccr.2011.12.028  0.84
2012 Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. RAC1 activation mediates Twist1-induced cancer cell migration. Nature Cell Biology. 14: 366-74. PMID 22407364 DOI: 10.1038/ncb2455  0.68
2012 Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 21: 105-20. PMID 22264792 DOI: 10.1016/j.ccr.2011.12.006  0.84
2012 Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, ... ... Hung MC, et al. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1 Cancer Research. 72: 1290-1300. PMID 22253230 DOI: 10.1158/0008-5472.CAN-11-3123  0.84
2012 Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Plos One. 7: e29416. PMID 22238610 DOI: 10.1371/journal.pone.0029416  0.84
2012 Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, ... ... Hung MC, et al. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell. 45: 171-84. PMID 22196886 DOI: 10.1016/j.molcel.2011.11.018  0.84
2012 Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC. Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. Journal of Cellular Physiology. 227: 1446-54. PMID 21618535 DOI: 10.1002/jcp.22860  0.8
2011 Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, ... ... Hung MC, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of Clinical Investigation. 121: 4526-36. PMID 21985787 DOI: 10.1172/JCI45008  0.84
2011 Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Research. 71: 6878-87. PMID 21911455 DOI: 10.1158/0008-5472.CAN-11-0295  0.84
2011 Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 20: 341-56. PMID 21907925 DOI: 10.1016/j.ccr.2011.07.017  0.84
2011 Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. European Journal of Pharmacology. 670: 96-104. PMID 21907193 DOI: 10.1016/j.ejphar.2011.08.006  0.68
2011 Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC. The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. Journal of the National Cancer Institute. 103: 1403-22. PMID 21813412 DOI: 10.1093/jnci/djr280  0.84
2011 Chen YJ, Huang WC, Wei YL, Hsu SC, Yuan P, Lin HY, Wistuba II, Lee JJ, Yen CJ, Su WC, Chang KY, Chang WC, Chou TC, Chou CK, Tsai CH, ... Hung MC, et al. Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. Plos One. 6: e21428. PMID 21731744 DOI: 10.1371/journal.pone.0021428  0.8
2011 Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. The Journal of Pathology. 225: 424-37. PMID 21710689 DOI: 10.1002/path.2921  0.84
2011 Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, Hung MC, Hung SC. Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology. 141: 1046-56. PMID 21699785 DOI: 10.1053/j.gastro.2011.05.045  0.84
2011 Chou RH, Yu YL, Hung MC. The roles of EZH2 in cell lineage commitment. American Journal of Translational Research. 3: 243-50. PMID 21654879  0.76
2011 Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Current Drug Targets. 12: 1284-90. PMID 21443462  1
2011 Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology. 13: 317-23. PMID 21336307 DOI: 10.1038/ncb2173  1
2011 Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology. 13: 174-81. PMID 21258366 DOI: 10.1038/ncb2158  0.96
2011 Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell. 19: 86-100. PMID 21215703 DOI: 10.1016/j.ccr.2010.10.035  0.84
2011 Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biology. 13: 87-94. PMID 21131960 DOI: 10.1038/ncb2139  1
2010 Hong S, Wang YN, Yamaguchi H, Sreenivasappa H, Chou CK, Tsou PH, Hung MC, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). Journal of Biomaterials and Nanobiotechnology. 1: 31-36. PMID 21804949 DOI: 10.4236/jbnb.2010.11004  0.76
2010 Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochemical and Biophysical Research Communications. 403: 103-7. PMID 21040707 DOI: 10.1016/j.bbrc.2010.10.126  1
2010 Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. The Analyst. 135: 2907-12. PMID 20877860 DOI: 10.1039/c0an00229a  0.84
2010 Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Research. 70: 7684-9. PMID 20841468 DOI: 10.1158/0008-5472.CAN-09-3231  1
2010 Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN, Hung MC. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation Oncogene. 29: 5619-5629. PMID 20676141 DOI: 10.1038/onc.2010.295  0.84
2010 Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M, Hung MC. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Research. 70: 5096-108. PMID 20501832 DOI: 10.1158/0008-5472.CAN-09-4148  1
2010 Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab On a Chip. 10: 1793-8. PMID 20498894 DOI: 10.1039/c002937h  0.84
2010 Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 70: 4709-18. PMID 20484037 DOI: 10.1158/0008-5472.CAN-09-4524  0.84
2010 Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Research. 70: 2424-34. PMID 20215498 DOI: 10.1158/0008-5472.CAN-09-0878  1
2010 Kuo HP, Hung MC. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? American Journal of Translational Research. 2: 56-64. PMID 20182582  0.96
2010 Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, ... ... Hung MC, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science Signaling. 3: ra9. PMID 20145209 DOI: 10.1126/scisignal.2000590  1
2009 Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, ... ... Hung MC, et al. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Molecular Cell. 36: 131-40. PMID 19818716 DOI: 10.1016/j.molcel.2009.07.025  0.96
2009 Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochemical and Biophysical Research Communications. 389: 640-4. PMID 19766100 DOI: 10.1016/j.bbrc.2009.09.042  0.96
2009 Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochemical and Biophysical Research Communications. 389: 156-61. PMID 19716809 DOI: 10.1016/j.bbrc.2009.08.127  0.96
2009 Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Molecular Carcinogenesis. 48: 1048-58. PMID 19526459 DOI: 10.1002/mc.20557  0.96
2009 Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 28: 2436-45. PMID 19448664 DOI: 10.1038/onc.2009.98  0.84
2009 Cheng X, Hung MC. Regulation of breast cancer metastasis by atypical chemokine receptors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2951-3. PMID 19383808 DOI: 10.1158/1078-0432.CCR-09-0141  1
2009 Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 752-7. PMID 19188143 DOI: 10.1158/1078-0432.CCR-08-0124  1
2008 Tsou PH, Chou CK, Saldana S, Hung MC, Kameoka J. The fabrication and testing of electrospun silica nanofiber membranes for the detection of proteins. Nanotechnology. 19: 445714. PMID 19081800 DOI: 10.1088/0957-4484/19/44/445714  0.84
2008 Lee DF, Kuo HP, Chen CT, Wei Y, Chou CK, Hung JY, Yen CJ, Hung MC. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. International Journal of Molecular Medicine. 22: 633-8. PMID 18949383 DOI: 10.3892/ijmm_00000065  0.84
2008 Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5656-62. PMID 18794072 DOI: 10.1158/1078-0432.CCR-08-0123  0.88
2008 Ding Q, Huo L, Yang JY, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, ... ... Hung MC, et al. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 68: 6109-17. PMID 18676833 DOI: 10.1158/0008-5472.CAN-08-0579  1
2008 Yen CJ, Izzo JG, Lee DF, Guha S, Wei Y, Wu TT, Chen CT, Kuo HP, Hsu JM, Sun HL, Chou CK, Buttar NS, Wang KK, Huang P, Ajani J, ... Hung MC, et al. Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. Cancer Research. 68: 2632-40. PMID 18413730 DOI: 10.1158/0008-5472.CAN-07-5460  0.96
2008 Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, ... ... Hung MC, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 10: 138-48. PMID 18204439 DOI: 10.1038/ncb1676  1
2007 Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle (Georgetown, Tex.). 6: 3011-4. PMID 18073529 DOI: 10.4161/cc.6.24.5085  0.88
2007 Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, Hsiao CD. Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Research. 35: 6984-94. PMID 17940099 DOI: 10.1093/nar/gkm703  1
2007 Cheng X, Hung MC. Breast cancer brain metastases. Cancer Metastasis Reviews. 26: 635-43. PMID 17717635 DOI: 10.1007/s10555-007-9083-x  1
2007 Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, ... ... Hung MC, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 130: 440-55. PMID 17693255 DOI: 10.1016/j.cell.2007.05.058  0.84
2007 Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, ... Hung MC, et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 12: 52-65. PMID 17613436 DOI: 10.1016/j.ccr.2007.05.009  0.96
2007 Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Research. 67: 4564-71. PMID 17495324 DOI: 10.1158/0008-5472.CAN-06-1788  1
2007 Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Molecular and Cellular Biology. 27: 4006-17. PMID 17387146 DOI: 10.1128/MCB.00620-06  0.92
2006 Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung MC. Tyrosine phosphorylation controls PCNA function through protein stability. Nature Cell Biology. 8: 1359-68. PMID 17115032 DOI: 10.1038/ncb1501  0.92
2006 Ping B, He X, Xia W, Lee DF, Wei Y, Yu D, Mills G, Shi D, Hung MC. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. International Journal of Oncology. 29: 1103-10. PMID 17016640  0.88
2006 Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation Molecular and Cellular Biology. 26: 7269-7282. PMID 16980628 DOI: 10.1128/MCB.00172-06  0.84
2006 Xia WY, Lien HC, Wang SC, Pan Y, Sahin A, Kuo YH, Chang KJ, Zhou X, Wang H, Yu Z, Hortobagyi G, Shi DR, Hung MC. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. Breast Cancer Research and Treatment. 98: 295-301. PMID 16752078 DOI: 10.1007/s10549-006-9162-7  0.32
2006 Yu Z, Xia W, Wang HY, Wang SC, Pan Y, Kwong KY, Hortobagyi GN, Hung MC. Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. Molecular Carcinogenesis. 45: 667-75. PMID 16652376 DOI: 10.1002/mc.20212  0.84
2006 Day CP, Rau KM, Qiu L, Liu CW, Kuo HP, Xie X, Lopez-Berestein G, Hortobagyi GN, Hung MC. Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model. Cancer Gene Therapy. 13: 706-19. PMID 16514421 DOI: 10.1038/sj.cgt.7700945  0.96
2006 Chou CK, Hung JY, Liu JC, Chen CT, Hung MC. An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein. Cancer Gene Therapy. 13: 746-52. PMID 16410824 DOI: 10.1038/sj.cgt.7700927  0.84
2006 Ou-Yang F, Lan KL, Chen CT, Liu JC, Weng CL, Chou CK, Xie X, Hung JY, Wei Y, Hortobagyi GN, Hung MC. Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells. Cancer Research. 66: 378-84. PMID 16397252 DOI: 10.1158/0008-5472.CAN-05-1578  0.84
2006 Hanada N, Lo HW, Day CP, Pan Y, Nakajima Y, Hung MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis. 45: 10-7. PMID 16299810 DOI: 10.1002/mc.20147  0.84
2005 Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and Cellular Biology. 25: 11005-18. PMID 16314522 DOI: 10.1128/MCB.25.24.11005-11018.2005  0.88
2005 Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (New York, N.Y.). 310: 306-10. PMID 16224021 DOI: 10.1126/science.1118947  0.92
2005 Rau KM, Kang HY, Cha TL, Miller SA, Hung MC. The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers. Endocrine-Related Cancer. 12: 511-32. PMID 16172190 DOI: 10.1677/erc.1.01026  0.92
2005 Lo HW, Day CP, Hung MC. Cancer-Specific Gene Therapy Advances in Genetics. 54: 233-255. PMID 16096014 DOI: 10.1016/S0065-2660(05)54010-0  0.84
2005 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, ... Hung MC, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 19: 159-70. PMID 16039586 DOI: 10.1016/j.molcel.2005.06.009  1
2005 Shao R, Lee DF, Wen Y, Ding Y, Xia W, Ping B, Yagita H, Spohn B, Hung MC. E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation. Molecular Cancer Research : McR. 3: 219-26. PMID 15831675 DOI: 10.1158/1541-7786.MCR-04-0084  0.92
2005 Cha TL, Qiu L, Chen CT, Wen Y, Hung MC. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Research. 65: 2287-95. PMID 15781642 DOI: 10.1158/0008-5472.CAN-04-3250  0.92
2004 Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 64: 9080-5. PMID 15604276 DOI: 10.1158/0008-5472.CAN-04-2419  1
2004 Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 6: 459-69. PMID 15542430 DOI: 10.1016/j.ccr.2004.09.027  1
2004 Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 6: 251-61. PMID 15380516 DOI: 10.1016/j.ccr.2004.07.012  0.88
2004 Chen JS, Liu JC, Shen L, Rau KM, Kuo HP, Li YM, Shi D, Lee YC, Chang KJ, Hung MC. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Therapy. 11: 740-7. PMID 15359286 DOI: 10.1038/sj.cgt.7700752  0.96
2004 Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3815-24. PMID 15173090 DOI: 10.1158/1078-0432.CCR-03-0527  0.88
2004 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 117: 225-37. PMID 15084260  1
2004 Makino K, Day CP, Wang SC, Li YM, Hung MC. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene. 23: 3883-7. PMID 15021910 DOI: 10.1038/sj.onc.1207485  0.84
2004 Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Molecular Carcinogenesis. 39: 139-46. PMID 14991743 DOI: 10.1002/mc.10169  0.92
2004 Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 23: 1896-901. PMID 14981540 DOI: 10.1038/sj.onc.1207314  0.84
2003 Li YM, Wen Y, Zhou BP, Kuo HP, Ding Q, Hung MC. Enhancement of Bik antitumor effect by Bik mutants. Cancer Research. 63: 7630-3. PMID 14633680  0.96
2003 Lee WP, Tai DI, Tsai SL, Yeh CT, Chao Y, Lee SD, Hung MC. Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine. Cancer Research. 63: 6229-36. PMID 14559808  0.6
2003 Wen Y, Giri D, Yan DH, Spohn B, Zinner RG, Xia W, Thompson TC, Matusik RJ, Hung MC. Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Molecular Carcinogenesis. 37: 130-7. PMID 12884364 DOI: 10.1002/mc.10129  0.92
2002 Kwong KY, Zou Y, Day CP, Hung MC. The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Oncogene. 21: 8340-6. PMID 12447697 DOI: 10.1038/sj.onc.1206050  0.84
2002 Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell. 2: 323-34. PMID 12398896  0.92
2002 Ding Y, Wen Y, Spohn B, Wang L, Xia W, Kwong KY, Shao R, Li Z, Hortobagyi GN, Hung MC, Yan DH. Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 3290-7. PMID 12374701  0.84
2002 Meric F, Lee WP, Sahin A, Zhang H, Kung HJ, Hung MC. Expression profile of tyrosine kinases in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 361-7. PMID 11839650  0.6
2002 Lee WP, Wen Y, Varnum B, Hung MC. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. 21: 329-36. PMID 11821945 DOI: 10.1038/sj.onc.1205066  0.92
2002 Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC. Systemic tumor suppression by the proapoptotic gene bik. Cancer Research. 62: 8-12. PMID 11782349  0.92
2001 Wen Y, Yan DH, Wang B, Spohn B, Ding Y, Shao R, Zou Y, Xie K, Hung MC. p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Cancer Research. 61: 7142-7. PMID 11585747  0.92
2001 Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nature Cell Biology. 3: 802-8. PMID 11533659 DOI: 10.1038/ncb0901-802  0.84
2000 Wen Y, Hu MC, Makino K, Spohn B, Bartholomeusz G, Yan DH, Hung MC. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Research. 60: 6841-5. PMID 11156376  0.92
2000 Meric F, Liao Y, Lee WP, Pollock RE, Hung MC. Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 3832-6. PMID 11051226  0.68
2000 Xia W, Lau YK, Hu MC, Li L, Johnston DA, Sheng Sj, El-Naggar A, Hung MC. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. Oncogene. 19: 2398-403. PMID 10828881 DOI: 10.1038/sj.onc.1203535  0.84
2000 Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 97: 4262-6. PMID 10759547 DOI: 10.1073/pnas.060025397  0.84
2000 Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. The Journal of Biological Chemistry. 275: 8027-31. PMID 10713122  0.84
2000 Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine. 6: 189-95. PMID 10655108 DOI: 10.1038/72294  0.84
2000 Wen Y, Yan DH, Spohn B, Deng J, Lin SY, Hung MC. Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells. Cancer Research. 60: 42-6. PMID 10646849  0.92
1999 Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, Liu AR, Li L, Katz RL, Hung MC. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 4164-74. PMID 10632356  0.84
1999 Lee WP, Liao Y, Robinson D, Kung HJ, Liu ET, Hung MC. Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Molecular and Cellular Biology. 19: 8075-82. PMID 10567533  0.68
1999 Hung MC, Lau YK. Basic science of HER-2/neu: A review Seminars in Oncology. 26: 51-59. PMID 10482194  0.84
1999 Zhang L, Lau YK, Xia W, Hortobagyi GN, Hung MC. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 5: 343-53. PMID 10037184  0.84
1999 Yan DH, Wen Y, Spohn B, Choubey D, Gutterman JU, Hung MC. Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202. Oncogene. 18: 807-11. PMID 9989832 DOI: 10.1038/sj.onc.1202369  0.92
1998 Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung MC. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene. 16: 2855-63. PMID 9671406 DOI: 10.1038/sj.onc.1201813  0.84
1997 Xia W, Lau YK, Zhang HZ, Liu AR, Li L, Kiyokawa N, Clayman GL, Katz RL, Hung MC. Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 3: 3-9. PMID 9815530  0.84
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