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Year Citation  Score
2022 Wang SH, Chou WC, Huang HC, Lee TA, Hsiao TC, Wang LH, Huang KB, Kuo CT, Chao CH, Chang SJ, Hsu JM, Weng J, Ren N, Li FA, Lai YJ, ... ... Hung MC, et al. Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis. American Journal of Cancer Research. 12: 4721-4736. PMID 36381324  0.31
2022 Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, ... ... Hung MC, et al. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Science Translational Medicine. 14: eabo1981. PMID 36322628 DOI: 10.1126/scitranslmed.abo1981  0.506
2022 Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, ... ... Hung MC, et al. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nature Cancer. PMID 36253486 DOI: 10.1038/s43018-022-00438-2  0.61
2022 Ho CT, Lin SP, Tseng LM, Hung MC, Hung SC. Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition. American Journal of Cancer Research. 12: 3932-3946. PMID 36119827  0.357
2022 Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, ... ... Hung MC, et al. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117857119. PMID 35412907 DOI: 10.1073/pnas.2117857119  0.772
2022 Zhao X, Wei Y, Chu YY, Li Y, Hsu JM, Jiang Z, Liu C, Hsu JL, Chang WC, Yang R, Chan LC, Qu J, Zhang S, Ying H, Yu D, ... Hung MC, et al. Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function. Cancer Research. PMID 35385574 DOI: 10.1158/0008-5472.CAN-21-2300  0.495
2022 Cha JH, Chan LC, Wang YN, Chu YY, Wang CH, Lee HH, Xia W, Shyu WC, Liu SP, Yao J, Chang CW, Cheng FR, Liu J, Lim SO, Hsu JL, ... ... Hung MC, et al. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. The Journal of Biological Chemistry. 101817. PMID 35278434 DOI: 10.1016/j.jbc.2022.101817  0.596
2022 Wang YN, Lee HH, Wei Y, Chu YY, Xia W, Wang M, Yu D, Hung MC. An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response. Star Protocols. 3: 101198. PMID 35243381 DOI: 10.1016/j.xpro.2022.101198  0.461
2021 Sun LL, Linghu DL, Hung MC. Ferroptosis: a promising target for cancer immunotherapy. American Journal of Cancer Research. 11: 5856-5863. PMID 35018229  0.327
2021 Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, ... ... Hung MC, et al. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nature Communications. 12: 7041. PMID 34873175 DOI: 10.1038/s41467-021-27349-7  0.305
2021 Lin YZ, Lee CC, Cho DY, Wang YL, Chen CY, Weng CY, Chiu SC, Hung MC, Wang SC. Suppression of breast cancer cells resistant to a pure anti-estrogen with CAR-transduced natural killer cells. American Journal of Cancer Research. 11: 4455-4469. PMID 34659898  0.302
2021 Wang YL, Lee CC, Shen YC, Lin PL, Wu WR, Lin YZ, Cheng WC, Chang H, Hung Y, Cho YC, Liu LC, Xia WY, Ji JH, Liang JA, Chiang SF, ... Hung MC, et al. Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Reports. 36: 109537. PMID 34433039 DOI: 10.1016/j.celrep.2021.109537  0.333
2021 Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Liu D, Bai X, Sun B, Hung MC, et al. Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture. American Journal of Cancer Research. 11: 2537-2567. PMID 34249415  0.344
2021 Qiu Y, Yang Y, Yang R, Liu C, Hsu JM, Jiang Z, Sun L, Wei Y, Li CW, Yu D, Zhang J, Hung MC. Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer. Oncogene. PMID 34172932 DOI: 10.1038/s41388-021-01896-1  0.509
2021 Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, ... Hung MC, et al. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nature Communications. 12: 2788. PMID 33986289 DOI: 10.1038/s41467-021-23075-2  0.62
2021 Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, ... ... Hung MC, et al. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. The Journal of Clinical Investigation. 131. PMID 33855973 DOI: 10.1172/JCI139434  0.476
2021 Yang R, Sun L, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, ... ... Hung MC, et al. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nature Communications. 12: 832. PMID 33547304 DOI: 10.1038/s41467-021-21099-2  0.676
2021 Gao Y, Chen MK, Chu YY, Yang L, Yu D, Liu Y, Hung MC. Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. American Journal of Cancer Research. 11: 236-250. PMID 33520371  0.592
2021 Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK, Hung MC, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. The Journal of Clinical Investigation. 131. PMID 33393490 DOI: 10.1172/JCI136779  0.383
2020 Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, ... ... Hung MC, et al. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics. 10: 10925-10939. PMID 33042262 DOI: 10.7150/Thno.49425  0.376
2020 Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, ... ... Hung MC, et al. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nature Cell Biology. PMID 32929201 DOI: 10.1038/S41556-020-0575-Z  0.371
2020 Jiang Z, Hsu JL, Li Y, Hortobagyi GN, Hung MC. Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment. Frontiers in Oncology. 10: 1197. PMID 32775303 DOI: 10.3389/Fonc.2020.01197  0.357
2020 Wang YN, Lee HH, Hsu JL, Yu D, Hung MC. The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis. Journal of Biomedical Science. 27: 77. PMID 32620165 DOI: 10.1186/S12929-020-00670-X  0.47
2020 Chen MK, Hsu JL, Hung MC. Nuclear receptor tyrosine kinase transport and functions in cancer. Advances in Cancer Research. 147: 59-107. PMID 32593407 DOI: 10.1016/Bs.Acr.2020.04.010  0.414
2020 Zhang L, Yao J, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S, Huse JT, ... Hung MC, et al. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Science Translational Medicine. 12. PMID 32461334 DOI: 10.1126/Scitranslmed.Aaz5387  0.499
2020 Han Y, Wei Y, Yao J, Chu YY, Li CW, Hsu JL, Nie L, Hung MC. Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma. American Journal of Cancer Research. 10: 1194-1206. PMID 32368395  0.392
2020 Zhou C, Liu C, Liu W, Chen W, Yin Y, Li CW, Hsu JL, Sun J, Zhou Q, Li H, Hu B, Fu P, Atyah M, Ma Q, Xu Y, ... ... Hung MC, et al. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Theranostics. 10: 4627-4643. PMID 32292519 DOI: 10.7150/Thno.42869  0.312
2020 Chou CK, Liu YL, Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Lee JF, Yankeelov TE, Kameoka J, Yeh HC, Hung MC. Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies. Acs Sensors. PMID 32073836 DOI: 10.1021/Acssensors.9B01736  0.497
2020 Hung M. Abstract IA23: Marker-guided targeted therapy, PARP inhibitors, and novel post-translational modification of PD-L1 Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-Ia23  0.359
2020 Cha J, Yang W, Xia W, Wei Y, Chan L, Lim S, Li C, Hsu J, Wang H, Kuo C, Chang W, Hadad S, Purdie C, McCoy A, Litton J, ... ... Hung M, et al. Abstract A16: Metformin is a potential nontoxic adjuvant to enhance the efficacy of non-PDL1/PD-1 targeting immune therapies Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-A16  0.374
2019 Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. American Journal of Cancer Research. 9: 2719-2729. PMID 31911857  0.354
2019 Yen YT, Chien M, Lai YC, Chen DP, Chuong CM, Hung MC, Hung SC. PP2A Deficiency Enhances Carcinogenesis of Lgr5 Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 9. PMID 31905853 DOI: 10.3390/Cells9010090  0.307
2019 Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nature Communications. 10: 5654. PMID 31827085 DOI: 10.1038/S41467-019-13508-4  0.304
2019 Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, ... ... Hung MC, et al. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nature Communications. 10: 5114. PMID 31704972 DOI: 10.1038/s41467-019-13105-5  0.379
2019 Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, et al. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. PMID 31554935 DOI: 10.1038/S41388-019-1010-4  0.382
2019 Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, et al. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nature Communications. 10: 4363. PMID 31554794 DOI: 10.1038/S41467-019-12377-1  0.316
2019 Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A Chirality-Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics. International Journal of Cancer. PMID 31472018 DOI: 10.1002/Ijc.32658  0.353
2019 Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Wei Y, Chou CK, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, ... ... Hung MC, et al. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Cancer Cell. PMID 31327656 DOI: 10.1016/j.ccell.2019.06.008  0.475
2019 Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, ... ... Hung MC, et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nature Immunology. PMID 31160797 DOI: 10.1038/S41590-019-0400-7  0.604
2019 Wang P, Gong Y, Guo T, Li M, Fang L, Yin S, Kamran M, Liu Y, Xu J, Xu L, Peng F, Xue X, Yang M, Hung MC, Lam EW, et al. Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Cell Death & Disease. 10: 432. PMID 31160567 DOI: 10.1038/s41419-019-1664-4  0.353
2019 Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J, Hung MC. HOinduces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bounded retrograde trafficking mechanism. The Journal of Biological Chemistry. PMID 30962283 DOI: 10.1074/jbc.RA118.005953  0.328
2019 Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX, Nie L, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD, Hung MC. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. American Journal of Cancer Research. 9: 608-618. PMID 30949414  0.376
2019 Liu YL, Chou CK, Kim M, Vasisht R, Kuo YA, Ang P, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov TE, Hung MC, et al. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Scientific Reports. 9: 3395. PMID 30833579 DOI: 10.1038/S41598-018-37625-0  0.599
2019 Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Billalabeitia EG, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nature Communications. 10: 636. PMID 30733438 DOI: 10.1038/S41467-019-08481-X  0.326
2019 Chen M, Du Y, Sun L, Hsu JL, Wang Y, Gao Y, Huang J, Hung M. Abstract 845: c-MET nuclear transportation via membrane-bounded retrograde trafficking in breast cancer cells Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-845  0.359
2018 Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, ... Hung MC, et al. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nature Genetics. PMID 30349115 DOI: 10.1038/S41588-018-0252-3  0.331
2018 Yam C, Hung MC, Hortobagyi GN. CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line? Oncotarget. 9: 34193-34195. PMID 30344934 DOI: 10.18632/Oncotarget.26134  0.378
2018 Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W, Xia W, Rao PH, Zhao R, Hung MC, et al. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Research. 33: 36-40. PMID 30312871 DOI: 10.1016/J.Scr.2018.10.003  0.734
2018 Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nature Cell Biology. PMID 30202049 DOI: 10.1038/S41556-018-0178-0  0.313
2018 Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, ... Hung MC, et al. Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. Cancer Research. PMID 29967256 DOI: 10.1158/0008-5472.Can-17-0385  0.48
2018 Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC. A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues. Biosensors & Bioelectronics. 117: 97-103. PMID 29890396 DOI: 10.1016/J.Bios.2018.05.053  0.544
2018 Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, ... Hung MC, et al. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Research. 29: 215-219. PMID 29730572 DOI: 10.1016/j.scr.2018.04.013  0.746
2018 Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, ... Hung MC, et al. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports. 23: 823-837. PMID 29669287 DOI: 10.1016/J.Celrep.2018.03.078  0.342
2018 Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, ... ... Hung MC, et al. Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. Cancer Cell. PMID 29606349 DOI: 10.1016/J.Ccell.2018.02.012  0.546
2018 Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, ... ... Hung MC, et al. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 33: 187-201.e10. PMID 29438695 DOI: 10.1016/J.Ccell.2018.01.009  0.546
2018 Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, et al. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Research. 27: 131-135. PMID 29414603 DOI: 10.1016/j.scr.2018.01.035  0.753
2018 Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, ... ... Hung MC, et al. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Molecular Cell. 69: 279-291.e5. PMID 29351847 DOI: 10.1016/J.Molcel.2017.12.024  0.364
2018 Lim S, Li C, Hung M. Abstract 5606: Eradication of triple-negative breast cancer cells by targeting glycosylated PD-L1 Cancer Research. 78: 5606-5606. DOI: 10.1158/1538-7445.Am2018-5606  0.33
2018 Hossain MB, Shifat R, Kim DK, Rivera-Molina Y, Martinez FP, Jiang H, Nguyen T, Johnson DG, Bedford MT, Hung M, Sulman EP, Lang F, Sawaya R, Fueyo J, Gomez-Manzano C. Abstract 3205: Histone tyrosine phosphorylation determines glioblastoma cell survival Cancer Research. 78: 3205-3205. DOI: 10.1158/1538-7445.Am2018-3205  0.417
2018 Liu Y, Chou C, Kim M, Vasisht R, Liu C, Perillo EP, Horng H, Hung M, Dunn AK, Yeh T. Effect of Epithelial-Mesenchymal Transition on EGFR Dynamics Revealed by Single-Particle Tracking Biophysical Journal. 114: 534a. DOI: 10.1016/J.Bpj.2017.11.2920  0.529
2017 Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S. Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. American Journal of Cancer Research. 7: 2587-2599. PMID 29312811  0.543
2017 Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robotics. 4: 390-399. PMID 29251562 DOI: 10.1089/Soro.2016.0073  0.537
2017 Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, ... Hung MC, et al. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. The Journal of Clinical Investigation. PMID 29130936 DOI: 10.1172/Jci91553  0.589
2017 Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, ... ... Hung MC, et al. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers. Science Translational Medicine. 9. PMID 29118262 DOI: 10.1126/Scitranslmed.Aao4307  0.334
2017 Yamaguchi H, Du Y, Nakai K, Ding M, Chang SS, Hsu JL, Yao J, Wei Y, Nie L, Jiao S, Chang WC, Chen CH, Yu Y, Hortobagyi GN, Hung MC. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. Oncogene. PMID 28925391 DOI: 10.1038/Onc.2017.311  0.357
2017 Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Molecular Cell. 67: 733-743.e4. PMID 28844863 DOI: 10.1016/J.Molcel.2017.07.026  0.552
2017 Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Martinez FP, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 associates with caveolae and regulates caveolin-1 to promote their nuclear translocation. Molecular and Cellular Biology. PMID 28760776 DOI: 10.1128/Mcb.00142-17  0.43
2017 Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. International Journal of Cancer. PMID 28214331 DOI: 10.1002/ijc.30658  0.346
2017 Jiao S, Xia W, Yamaguchi H, Wei Y, Chen MK, Hsu JM, Hsu JL, Yu WH, Du Y, Lee HH, Li CW, Chou CK, Lim SO, Chang SS, Litton JK, ... ... Hung MC, et al. PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28167507 DOI: 10.1158/1078-0432.CCR-16-3215  0.499
2017 Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, González-Billalabeitia E, Hung MC, Song SJ, Song MS. A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. PMID 28162974 DOI: 10.1016/j.ccell.2017.01.003  0.312
2017 Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer. Annals of Surgical Oncology. PMID 28160139 DOI: 10.1245/s10434-017-5769-7  0.324
2017 Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, ... Hung MC, et al. Metastasis regulation by PPARD expression in cancer cells. Jci Insight. 2: e91419. PMID 28097239 DOI: 10.1172/Jci.Insight.91419  0.461
2017 Korphaisarn K, Chou C, Xia W, Clarke C, Davis JS, Liao H, Crosby S, Manuel S, Wu J, Menter D, Hung M, Kopetz S. Arginine methylation of EGFR in circulating tumor cells: A new biomarker for predicting resistance to anti-EGFR agents. Journal of Clinical Oncology. 35: 3590-3590. DOI: 10.1200/Jco.2017.35.15_Suppl.3590  0.589
2017 Lim S, Li C, Hung M. Abstract B47: Stabilization of programmed death ligand-1 by epidermal growth factor enhances cancer cell immune escape Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B47  0.349
2017 Goverdhan A, Lee H, Havranek O, Davis RE, Hung M. Abstract 13: PRMT1 as a therapeutic target in diffuse large B-cell lymphoma Clinical Cancer Research. 23: 13-13. DOI: 10.1158/1557-3265.Hemmal17-13  0.381
2017 Nie L, Wei Y, Yamaguchi H, Huo L, Xia W, Deng R, Tang J, Zhu C, Ke B, Hung M. Abstract LB-131: Targeting expression of EZH2 with increased H3K27 trimethylation activity drives and synergizes with oncogene to promote mammary tumorigenesis in genetically engineered mouse models Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-131  0.44
2017 Hossain MB, Shifat R, Li J, Rivera-Mokina Y, Martinez FP, Johnson DG, Bedford MT, Hung M, Sulman EP, Lang F, Sawaya R, Fueyo J, Gomez-Manzano C. Abstract 5854: TIE2-mediated epigenetic marks regulate therapeutic resistance of glioblastoma Cancer Research. 77: 5854-5854. DOI: 10.1158/1538-7445.Am2017-5854  0.302
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2016 Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, ... ... Hung MC, et al. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature Communications. 7: 12632. PMID 27572267 DOI: 10.1038/Ncomms12632  0.485
2016 Lee CJ, Hsu LS, Yue CH, Lin H, Chiu YW, Lin YY, Huang CY, Hung MC, Liu JY. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells. Oncotarget. PMID 27542222 DOI: 10.18632/oncotarget.11337  0.346
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2016 Chang TY, Chen HA, Chiu CF, Chang YW, Kuo TC, Tseng PC, Wang W, Hung MC, Su JL. Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL. Cancer Research. PMID 27216190 DOI: 10.1158/0008-5472.CAN-15-2555  0.363
2016 Chen MK, Hung MC. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. American Journal of Cancer Research. 6: 827-42. PMID 27186434  0.359
2016 Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. American Journal of Cancer Research. 6: 628-38. PMID 27152240  0.401
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2016 Lim SO, Li CW, Xia W, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, ... Hung MC, et al. EGFR signaling enhances aerobic glycolysis in triple negative breast cancer cells to promote tumor growth and immune escape. Cancer Research. PMID 26759242 DOI: 10.1158/0008-5472.Can-15-2478  0.368
2016 Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, ... Hung MC, et al. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation. Cancer Research. PMID 26759241 DOI: 10.1158/0008-5472.CAN-15-1941  0.839
2016 Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, ... Hung MC, et al. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nature Cell Biology. PMID 26751287 DOI: 10.1038/Ncb3295  0.35
2016 Niu N, Zhang J, Zhang N, Mercado-Uribe I, Tao F, Han Z, Pathak S, Multani A, Kuang J, Yao J, Bast R, Sood A, Hung M, Liu J. Abstract LB-119: Single-cell live imaging of paclitaxel-resistant cancer cell generation Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-119  0.41
2016 Liao H, Hsu J, Xia W, Hung M. Abstract LB-002: Methylation of the EGF receptor regulates signaling and therapeutic response Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-002  0.389
2016 Liu Y, Perillo EP, Liu C, Yu PM, Chou C, Hung M, Dunn AK, Yeh T. Dynamics of EGFR Trafficking from Membrane into Deep Cytoplasm Revealed by a Spatiotemporally Multiplexed 3D Tracking Microscope Biophysical Journal. 110: 638a. DOI: 10.1016/J.Bpj.2015.11.3416  0.537
2015 Rahal OM, Nie L, Chan LC, Li CW, Hsu YH, Hsu J, Yu D, Hung MC. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. American Journal of Cancer Research. 5: 3624-34. PMID 26885451  0.597
2015 Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, ... ... Hung MC, et al. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. The Journal of Clinical Investigation. PMID 26571401 DOI: 10.1172/Jci82826  0.569
2015 Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, Zhang X, Li N, Bose S, Wang Q, Sakkiah S, Abrol R, Jensen TW, Berman BP, Tanaka H, ... Hung MC, et al. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Reports. 13: 1046-1058. PMID 26565916 DOI: 10.1016/J.Celrep.2015.09.063  0.395
2015 Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, ... Hung MC, et al. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. PMID 26481148 DOI: 10.1016/J.Ccell.2015.09.008  0.829
2015 Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nature Communications. 6: 8419. PMID 26420673 DOI: 10.1038/Ncomms9419  0.317
2015 Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, ... ... Hung MC, et al. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. American Journal of Translational Research. 7: 1009-20. PMID 26279746  0.826
2015 Perillo EP, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nature Communications. 6: 7874. PMID 26219252 DOI: 10.1038/Ncomms8874  0.493
2015 Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, ... Hung MC, et al. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. PMID 26212011 DOI: 10.1038/Onc.2015.279  0.482
2015 Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, ... Hung MC, et al. The ZNF304-integrin axis protects against anoikis in cancer. Nature Communications. 6: 7351. PMID 26081979 DOI: 10.1038/Ncomms8351  0.349
2015 Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Proteasome inhibition enhances the killing effect of BikDD gene therapy. American Journal of Translational Research. 7: 319-27. PMID 25901200  0.332
2015 Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Research. 75: 1846-58. PMID 25877877 DOI: 10.1158/0008-5472.Can-14-2718  0.409
2015 Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 161: 240-54. PMID 25860607 DOI: 10.1016/J.Cell.2015.02.045  0.806
2015 Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, ... Hung MC, et al. 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 27: 177-92. PMID 25670079 DOI: 10.1016/J.Ccell.2014.11.025  0.557
2015 Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, et al. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Molecular Oncology. 9: 586-600. PMID 25435280 DOI: 10.1016/J.Molonc.2014.10.011  0.592
2015 Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer. Annals of Surgical Oncology. 22: 889-98. PMID 25212833 DOI: 10.1245/s10434-014-4061-3  0.31
2015 Chang S, Yamaguchi H, Hung M. Abstract B03: Cisplatin-resistant cells possess collateral sensitivity to folate antimetabolites Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-B03  0.365
2015 Xu J, Acharya S, Sahin O, Zhang L, Lowery FJ, Sahin AA, Zhang XH-, Hung M, Yu D. Abstract LB-202: 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2 Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-202  0.614
2015 Lee D, Su J, Kim HS, Chang B, Zhao R, Papatsenko D, Yuan Y, Gingold J, Xia W, Darr H, Schaniel C, Mirzayans R, Hung M, Lemischka IR. Abstract 5129: Model osteosarcoma by Li-Fraumeni syndrome patient-specific induced pluripotent stem cells Cancer Research. 75: 5129-5129. DOI: 10.1158/1538-7445.Am2015-5129  0.709
2015 Chou C, Lee H, Tsou P, Chen C, Hsu J, Yamaguchi H, Wang Y, Hsu JL, Lee J, Kameoka J, Hung M. Abstract 5120: Using flow-proteometric platform to analyze individual signaling complexes in tumor tissue Cancer Research. 75: 5120-5120. DOI: 10.1158/1538-7445.Am2015-5120  0.601
2015 Chen J, Chen J, Zhang J, Phan L, Muñoz NM, Katz LH, Gi Y, Menon VK, Shin J, Jeong YS, Jogunoori W, Farci P, Shetty K, Su X, Pandita TK, ... ... Hung M, et al. Abstract 3900: Genomic landscape of human cancer reveals dysregulated TGF-β signaling with prognostic significance Cancer Research. 75: 3900-3900. DOI: 10.1158/1538-7445.Am2015-3900  0.334
2015 Hossain MB, Shifat R, Johnson DG, Bedford MT, Hung M, Cortes-Santiago N, Gabrusiewicz K, Gumin J, Ezhilarasan R, Sulman EP, Lang F, Sawaya R, Yung WKA, Fueyo J, Gomez-Manzano C. Abstract 3298: ABL1 is required for Tie2-mediated DNA repair in brain tumor stem cells Cancer Research. 75: 3298-3298. DOI: 10.1158/1538-7445.Am2015-3298  0.398
2015 Nie L, Wei Y, LaBaff A, Yang C, Xia W, Huo L, Liu D, Hsu Y, Hortobagyi GN, Yao J, Kleer CG, Hung M. Abstract 2895: Phosphorylation of EZH2 at T416 by CDK2 promotes development of mammary tumors with basal-like phenotype Cancer Research. 75: 2895-2895. DOI: 10.1158/1538-7445.Am2015-2895  0.486
2015 Rojas A, Zhang P, Wang Y, Munoz NM, Xiao L, Wang J, Gores GJ, Hung M, Blechacz BRA. Abstract 1962: TGF-β/SMAD2 signaling drives tumor-progression via c-KIT/STAT3-signaling in advanced HCC Cancer Research. 75: 1962-1962. DOI: 10.1158/1538-7445.Am2015-1962  0.334
2015 Hossain MB, Shifat R, Johnson DG, Bedford MT, Hung M, Gabrusiewicz K, Gumin J, Ezhilarasan R, Sulman EP, Lang F, Tyler J, Sawaya R, Yung WA, Fueyo J, Gomez-Manzano C. RTRB-10TYROSINE KINASE RECEPTOR TIE2 REGULATES DNA REPAIR THROUGH THE PROTO-ONCOGENE ABL1 IN BRAIN TUMOR STEM CELLS Neuro-Oncology. 17: v197.2-v197. DOI: 10.1093/Neuonc/Nov231.10  0.398
2014 Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, ... ... Hung MC, et al. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. American Journal of Translational Research. 6: 649-63. PMID 25628777  0.778
2014 Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 159: 1110-25. PMID 25416949 DOI: 10.1016/j.cell.2014.10.013  0.35
2014 Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT, Hung MC, Wu CH, Huang MT, Su JL. De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Oncotarget. 5: 10558-70. PMID 25301734 DOI: 10.18632/ONCOTARGET.2510  0.361
2014 Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, ... ... Hung MC, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nature Cell Biology. 16: 864-75. PMID 25086746 DOI: 10.1038/Ncb3013  0.311
2014 Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y, Xia W, Yu D, Hung MC. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. American Journal of Translational Research. 6: 361-76. PMID 25075253  0.628
2014 Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Science Signaling. 7: ra71. PMID 25074979 DOI: 10.1126/Scisignal.2005076  0.64
2014 Debeb BG, Gong Y, Atkinson RL, Sneige N, Huo L, Gonzalez-Angulo AM, Hung MC, Valero V, Ueno NT, Woodward WA. EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. Journal of Experimental & Clinical Cancer Research : Cr. 33: 58. PMID 25051981 DOI: 10.1186/S13046-014-0058-9  0.404
2014 Yamaguchi H, Hung MC. Regulation and Role of EZH2 in Cancer. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 46: 209-22. PMID 25038756 DOI: 10.4143/crt.2014.46.3.209  0.31
2014 Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, ... Hung MC, et al. Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Research. 74: 4822-35. PMID 24970481 DOI: 10.1158/0008-5472.Can-14-0584  0.624
2014 Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. The Journal of Clinical Investigation. 124: 3093-106. PMID 24911147 DOI: 10.1172/JCI73351  0.805
2014 Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, ... Hung MC, et al. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Research. 74: 4170-82. PMID 24906622 DOI: 10.1158/0008-5472.Can-13-3569  0.455
2014 Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, ... ... Hung MC, et al. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Molecular Cell. 54: 960-74. PMID 24857548 DOI: 10.1016/j.molcel.2014.04.024  0.328
2014 Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MC. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Science Signaling. 7: rs1. PMID 24595109 DOI: 10.1126/Scisignal.2004620  0.548
2014 Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-Cell-Printing for live single-cell printing. Proceedings of the National Academy of Sciences of the United States of America. 111: 2948-53. PMID 24516129 DOI: 10.1073/Pnas.1313661111  0.555
2014 Chang YW, Hung MC, Su JL. The anti-tumor activity of E1A and its implications in cancer therapy. Archivum Immunologiae Et Therapiae Experimentalis. 62: 195-204. PMID 24504082 DOI: 10.1007/s00005-014-0273-2  0.365
2014 Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. The Journal of Clinical Investigation. 124: 564-79. PMID 24382352 DOI: 10.1172/Jci71104  0.55
2014 Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Molecular Carcinogenesis. 53: 1011-26. PMID 24000122 DOI: 10.1002/Mc.22068  0.325
2014 Yamaguchi H, Chang SS, Hsu JL, Hung MC. Signaling cross-talk in the resistance to HER family receptor targeted therapy. Oncogene. 33: 1073-81. PMID 23542173 DOI: 10.1038/Onc.2013.74  0.389
2014 Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 33: 756-70. PMID 23376851 DOI: 10.1038/onc.2013.1  0.796
2014 Khotskaya YB, Goverdhan A, Shen J, Sarvice MP, Chang S, Hsu M, Wei Y, Xia W, Steeg P, Yu D, Hung M. Abstract A49: S6K1 promotes invasiveness of breast cancer cells in a novel model of triple-negative breast cancer metastasis Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-A49  0.66
2014 Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Cascone T, Giri D, Kim J, Ye Y, Multani A, Chan C, Erez B, Saigal B, Lin H, ... Hung M, et al. Abstract 5146: The histone demethylase KDM2A is a new promoter of tumorigenesis, drug target and negative prognostic biomarker for non-small cell lung cancer Cancer Research. 74: 5146-5146. DOI: 10.1158/1538-7445.Am2014-5146  0.455
2014 Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Jin J, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Martin JF, ... Hung M, et al. Abstract 3896: The Hippo coactivator YAP1 upregulates SOX9 and endows cancer stem cell properties in non-transformed cells and esophageal cancer cells Cancer Research. 74: 3896-3896. DOI: 10.1158/1538-7445.Am2014-3896  0.449
2014 Chen J, Chen J, Gi Y, Katz LH, Shin J, Phan L, Jogunoori W, Shukla V, Mishra B, Li S, Javle M, Hung M, Mishra L. Abstract 2784: Targeting TGF-β regulated E3 ligases: a novel therapeutic approach for primary liver cancer Cancer Research. 74: 2784-2784. DOI: 10.1158/1538-7445.Am2014-2784  0.384
2014 Chen J, Chen J, Gi Y, Katz LH, Shin J, Phan LM, Jogunoori W, Shukla V, Mishra B, Li S, Javle M, Hung M, Mishra L. 641 TGF-β? Regulated E3 Ligase Are Novel Therapeutic Targets for Primary Liver Cancer Gastroenterology. 146: S-918. DOI: 10.1016/S0016-5085(14)63337-0  0.316
2013 Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology. 15: 1486-94. PMID 24270891 DOI: 10.1038/Ncb2874  0.359
2013 Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, ... ... Hung MC, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. The Journal of Clinical Investigation. 123: 5231-46. PMID 24200691 DOI: 10.1172/Jci68642  0.4
2013 Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. Plos One. 8: e73406. PMID 24039934 DOI: 10.1371/Journal.Pone.0073406  0.691
2013 Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Research. 73: 6516-25. PMID 24014597 DOI: 10.1158/0008-5472.Can-13-0967  0.442
2013 Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154: 556-68. PMID 23911321 DOI: 10.1016/j.cell.2013.06.048  0.351
2013 Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, ... ... Hung MC, et al. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 23: 796-810. PMID 23764002 DOI: 10.1016/j.ccr.2013.04.027  0.749
2013 Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. Plos One. 8: e61362. PMID 23593472 DOI: 10.1371/journal.pone.0061362  0.363
2013 Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, ... Hung MC, et al. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. Embo Molecular Medicine. 5: 531-47. PMID 23526793 DOI: 10.1002/emmm.201201783  0.777
2013 Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 23: 316-31. PMID 23453623 DOI: 10.1016/J.Ccr.2013.01.022  0.326
2013 Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes & Development. 27: 274-87. PMID 23388826 DOI: 10.1101/Gad.203760.112  0.386
2013 Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Molecular Pharmacology. 83: 857-69. PMID 23355539 DOI: 10.1124/mol.112.082743  0.359
2013 Liu CM, Hsieh CL, He YC, Lo SJ, Liang JA, Hsieh TF, Josson S, Chung LW, Hung MC, Sung SY. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. Plos One. 8: e53795. PMID 23342005 DOI: 10.1371/Journal.Pone.0053795  0.309
2013 Huang WH, Chang MC, Tsai KS, Hung MC, Chen HL, Hung SC. Mesenchymal stem cells promote growth and angiogenesis of tumors in mice. Oncogene. 32: 4343-54. PMID 23085755 DOI: 10.1038/Onc.2012.458  0.437
2013 Sher YP, Chang CM, Juo CG, Chen CT, Hsu JL, Lin CY, Han Z, Shiah SG, Hung MC. Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth. Oncogene. 32: 1082-90. PMID 22562248 DOI: 10.1038/Onc.2012.134  0.44
2013 Wei Y, Chang S, Wang H, Xia W, Hung M. Abstract 5351: Phosphorylation of EZH2 at Thr487 is a marker for good prognosis in pancreatic cancer patients. Cancer Research. 73: 5351-5351. DOI: 10.1158/1538-7445.Am2013-5351  0.392
2013 Chou C, Lee H, Tsou P, Yamaguchi H, Wang Y, Lee H, Kameoka J, Hung M. Abstract 5169: Flow-proteometric analysis of single signaling complex. Cancer Research. 73: 5169-5169. DOI: 10.1158/1538-7445.Am2013-5169  0.603
2013 Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward W, Reuben JM, Hortobagyi GN, Hung M, Ueno NT. Abstract 3032: Tazarotene-induced gene 1 promotes tumorigenicity and invasiveness of inflammatory breast cancer through receptor tyrosine kinase Axl. Cancer Research. 73: 3032-3032. DOI: 10.1158/1538-7445.Am2013-3032  0.445
2013 Lim S, Li C, Chang S, Shen J, Hung M. Abstract 3027: A novel function of EGFR in epigenetic modulation via hMOF in breast cancer . Cancer Research. 73: 3027-3027. DOI: 10.1158/1538-7445.Am2013-3027  0.469
2013 Rojas A, Cromheecke J, Lee M, Hung M, Blechacz B. Abstract 2046: TGF-β drives tumor-progression via JAK/STAT3-signaling in advanced HCC. Cancer Research. 73: 2046-2046. DOI: 10.1158/1538-7445.Am2013-2046  0.323
2013 Holder AM, Adkins F, Akcakanat A, Chen H, Do K, Hung M, Meric-Bernstam F. Abstract 1496: Epithelial to mesenchymal transition and rapamycin sensitivity in cancer cell lines. Cancer Research. 73: 1496-1496. DOI: 10.1158/1538-7445.Am2013-1496  0.448
2013 Yamaguchi H, Hsu JL, Chen C, Wang Y, Hsu M, Chang S, Du Y, Ko H, Herbst RS, Hung M. Abstract 1051: EGFR inhibitors attenuate caspase-independent cell death and confer negative effects on cisplatin . Cancer Research. 73: 1051-1051. DOI: 10.1158/1538-7445.Am2013-1051  0.407
2013 Zuo M, Rashid A, Churi C, Hung M, Javle M. Abstract C171: Novel therapeutic strategies targeting the hedgehog signaling pathway and mTOR pathway in biliary tract cancer (BTC). Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C171  0.484
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KKC, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, et al. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell. 151: 913-914. PMID 30360292 DOI: 10.1016/J.Cell.2012.10.025  0.501
2012 Ho TH, Monzon FA, Hoang A, Tamboli P, Furge KA, Dykema K, Petillo D, Teh BT, Tannir NM, Hung MC, Jonasch E. Regulation of SETD2, a histone methyltransferase, in advanced clear cell renal cell carcinoma (ccRCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 368. PMID 27968196 DOI: 10.1200/Jco.2012.30.5_Suppl.368  0.356
2012 Hong S, Tsou PH, Chou CK, Yamaguchi H, Su CB, Hung MC, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 6: 24132. PMID 23785388 DOI: 10.1063/1.4730332  0.472
2012 Li L, Xie X, Luo J, Liu M, Xi S, Guo J, Kong Y, Wu M, Gao J, Xie Z, Tang J, Wang X, Wei W, Yang M, Hung MC, et al. Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2326-34. PMID 23032974 DOI: 10.1038/Mt.2012.201  0.336
2012 Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine. 18: 1511-7. PMID 23001183 DOI: 10.1038/Nm.2940  0.375
2012 Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, ... ... Hung MC, et al. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 11: 179-94. PMID 22862944 DOI: 10.1016/J.Stem.2012.05.020  0.811
2012 Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKKβ/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Molecular Cancer Therapeutics. 11: 2212-21. PMID 22826466 DOI: 10.1158/1535-7163.MCT-12-0180  0.705
2012 Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. The Journal of Biological Chemistry. 287: 31015-26. PMID 22815474 DOI: 10.1074/jbc.M112.358077  0.349
2012 Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W, Hung MC, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Molecular Cancer Therapeutics. 11: 1915-24. PMID 22752427 DOI: 10.1158/1535-7163.Mct-12-0191  0.431
2012 Yamaguchi H, Hsu JL, Hung MC. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Frontiers in Oncology. 2: 15. PMID 22649777 DOI: 10.3389/fonc.2012.00015  0.396
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149: 1098-111. PMID 22632973 DOI: 10.1016/J.Cell.2012.02.065  0.63
2012 Ouelaa-Benslama R, De Wever O, Hendrix A, Sabbah M, Lambein K, Land D, Prévost G, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C. Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition International Journal of Oncology. 41: 189-200. PMID 22552300 DOI: 10.3892/ijo.2012.1457  0.411
2012 Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, ... ... Hung MC, et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 21: 374-87. PMID 22439934 DOI: 10.1016/j.ccr.2011.12.028  0.767
2012 Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. RAC1 activation mediates Twist1-induced cancer cell migration. Nature Cell Biology. 14: 366-74. PMID 22407364 DOI: 10.1038/ncb2455  0.342
2012 Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 21: 105-20. PMID 22264792 DOI: 10.1016/J.Ccr.2011.12.006  0.777
2012 Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, ... Hung MC, et al. Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1 Cancer Research. 72: 1290-1300. PMID 22253230 DOI: 10.1158/0008-5472.CAN-11-3123  0.361
2012 Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Plos One. 7: e29416. PMID 22238610 DOI: 10.1371/Journal.Pone.0029416  0.398
2012 Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 31: 4372-83. PMID 22231447 DOI: 10.1038/Onc.2011.608  0.446
2012 Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, ... Hung MC, et al. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell. 45: 171-84. PMID 22196886 DOI: 10.1016/J.Molcel.2011.11.018  0.832
2012 Ho TH, Monzon FA, Hoang A, Tamboli P, Furge KA, Dykema K, Petillo D, Teh BT, Tannir NM, Hung M, Jonasch E. Molecular characterization of SETD2, a histone methyltransferase, in clear cell renal cell carcinoma (ccRCC). Journal of Clinical Oncology. 30: 4624-4624. DOI: 10.1200/Jco.2012.30.15_Suppl.4624  0.33
2012 Wang Y, Xia W, Lang J, Hsu J, Wang H, Ajani J, Hung M. Abstract 989: The crosstalk of mTOR/S6K1 and Hedgehog pathways Cancer Research. 72: 989-989. DOI: 10.1158/1538-7445.Am2012-989  0.416
2012 Yang P, Hsieh C, Hung M, Kuo F, Huang Y, Lee J. Abstract 3465: The effect of ephrin-A1 on the resistance of photodynamic therapy in esophageal cancer cells Cancer Research. 72: 3465-3465. DOI: 10.1158/1538-7445.Am2012-3465  0.413
2012 Khotskaya YB, Shen J, Chang S, Yu D, Steeg PS, Hung M. Abstract 3290: A novel model of breast cancer metastasis: Killing two birds with one stone Cancer Research. 72: 3290-3290. DOI: 10.1158/1538-7445.Am2012-3290  0.603
2012 Zhao HJ, Ho P, Lo Y, Espejo A, Bedford MT, Hung M, Wang S. Abstract 3036: Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer Cancer Research. 72: 3036-3036. DOI: 10.1158/1538-7445.Am2012-3036  0.496
2012 Du Y, Shen J, Hsu JL, Han Z, Wang Y, Yamaguchi H, Miller SA, Hung M. Abstract 1230: Syntaxin 6- and microtubule-mediated intracellular trafficking contributes to Golgi and nuclear translocation of EGFR Cancer Research. 72: 1230-1230. DOI: 10.1158/1538-7445.Am2012-1230  0.391
2012 Ho TH, Monzon FA, Hoang A, Tamboli P, Furge K, Dykema K, Petillo D, Teh BT, Tannir N, Jonasch E, Hung M. Abstract 1035: SETD2, a histone methyltransferase, is misregulated in advanced clear cell renal cell carcinoma (ccRCC) Cancer Research. 72: 1035-1035. DOI: 10.1158/1538-7445.Am2012-1035  0.361
2011 Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, ... ... Hung MC, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of Clinical Investigation. 121: 4526-36. PMID 21985787 DOI: 10.1172/Jci45008  0.794
2011 Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Research. 71: 6878-87. PMID 21911455 DOI: 10.1158/0008-5472.Can-11-0295  0.839
2011 Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 20: 341-56. PMID 21907925 DOI: 10.1016/J.Ccr.2011.07.017  0.609
2011 Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. European Journal of Pharmacology. 670: 96-104. PMID 21907193 DOI: 10.1016/j.ejphar.2011.08.006  0.342
2011 Chen YJ, Huang WC, Wei YL, Hsu SC, Yuan P, Lin HY, Wistuba II, Lee JJ, Yen CJ, Su WC, Chang KY, Chang WC, Chou TC, Chou CK, Tsai CH, ... Hung MC, et al. Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. Plos One. 6: e21428. PMID 21731744 DOI: 10.1371/Journal.Pone.0021428  0.613
2011 Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. The Journal of Pathology. 225: 424-37. PMID 21710689 DOI: 10.1002/path.2921  0.309
2011 Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, Hung MC, Hung SC. Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology. 141: 1046-56. PMID 21699785 DOI: 10.1053/J.Gastro.2011.05.045  0.404
2011 Banerjee A, Lang JY, Hung MC, Sengupta K, Banerjee SK, Baksi K, Banerjee DK. Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. The Journal of Biological Chemistry. 286: 29127-38. PMID 21676868 DOI: 10.1074/jbc.M110.169771  0.303
2011 Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP, Wang YN, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH, Hung MC. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. The Journal of Biological Chemistry. 286: 20558-68. PMID 21487020 DOI: 10.1074/jbc.M111.240796  0.353
2011 Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Current Drug Targets. 12: 1284-90. PMID 21443462  0.839
2011 Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia (New York, N.Y.). 13: 286-98. PMID 21390191 DOI: 10.1593/Neo.11112  0.318
2011 Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology. 13: 317-23. PMID 21336307 DOI: 10.1038/Ncb2173  0.796
2011 Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology. 13: 174-81. PMID 21258366 DOI: 10.1038/Ncb2158  0.777
2011 Zhao H, Lo YH, Ma L, Waltz SE, Gray JK, Hung MC, Wang SC. Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Molecular Cancer Therapeutics. 10: 29-36. PMID 21220489 DOI: 10.1158/1535-7163.MCT-10-0778  0.328
2011 Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell. 19: 86-100. PMID 21215703 DOI: 10.1016/J.Ccr.2010.10.035  0.839
2011 Li LY, Dai HY, Yeh FL, Kan SF, Lang J, Hsu JL, Jeng LB, Chen YH, Sher YP, Lin WC, Hung MC. Targeted hepatocellular carcinoma proapoptotic BikDD gene therapy. Oncogene. 30: 1773-83. PMID 21151169 DOI: 10.1038/Onc.2010.558  0.383
2011 Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biology. 13: 87-94. PMID 21131960 DOI: 10.1038/ncb2139  0.82
2011 Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, ... Hung MC, et al. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Research. 71: 603-13. PMID 21123450 DOI: 10.1158/0008-5472.Can-10-3185  0.62
2011 Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, Yumul R, Zhang XB, Hung MC, Lieber A. Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 479-89. PMID 21081901 DOI: 10.1038/mt.2010.256  0.307
2011 Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, et al. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 30: 457-70. PMID 20856200 DOI: 10.1038/Onc.2010.421  0.486
2011 Li L, Chen H, Hsieh Y, Wang Y, Chu H, Tsai C, Hung M. Abstract A57: The novel function of nuclear ErbB-2 in regulating transcription of rRNA genes Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-A57  0.36
2011 Chang C, Hung M. Abstract 976: Hypoxic microenvironment promotes breast cancer stem cells through regulation of Polycomb protein expression Cancer Research. 71: 976-976. DOI: 10.1158/1538-7445.Am2011-976  0.51
2011 Yamaguchi H, Hsu J, Ko H, Wang Y, Chang S, Hung M. Abstract 721: Putative molecular mechanism contributing AZD6244 resistance in lung cancer Cancer Research. 71: 721-721. DOI: 10.1158/1538-7445.Am2011-721  0.307
2011 Chao C, Chang C, Xia W, Yang J, Xiong Y, Li C, Hung M. Abstract 4710: p53 regulates epithelial-mesenchymal transition (EMT) and stem cell properties through modulation of miRNAs Cancer Research. 71: 4710-4710. DOI: 10.1158/1538-7445.Am2011-4710  0.809
2011 Wang Y, Yamaguchi H, Huo L, Du Y, Lee H, Lee H, Wang H, Hsu J, Hung M. Abstract 4051: EGF receptor trafficking from the cell surface to the nucleus through the Golgi, ER, and nuclear envelope Cancer Research. 71: 4051-4051. DOI: 10.1158/1538-7445.Am2011-4051  0.337
2011 Khotskaya YB, Beck BH, Hurst DR, Hung M, Welch DR. Abstract 1438: Breast cancer metastasis suppressor 1 (BRMS1) suppresses attachment and spreading of breast cancer cells on 2D and 3D extracellular matrix components by altering focal adhesion-associated signaling Cancer Research. 71: 1438-1438. DOI: 10.1158/1538-7445.Am2011-1438  0.447
2011 Huo L, Wang Y, Xia W, Hsu S, Lai C, Li L, Chang W, Wang Y, Hsu M, Yu Y, Huang T, Ding Q, Chen C, Tsai C, Hung M. Abstract 1086: RHA plays an important role in EGFR-mediated gene transcription in cancer cells Cancer Research. 71: 1086-1086. DOI: 10.1158/1538-7445.Am2011-1086  0.438
2011 Adkins F, Kim W, Akcakanat A, Singh G, Hung M, Meric-Bernstam F. Differential Regulation Of Tumor Suppressor PDCD4 Expression By Rapamycin Journal of Surgical Research. 165: 178. DOI: 10.1016/J.Jss.2010.11.762  0.355
2010 Hong S, Wang YN, Yamaguchi H, Sreenivasappa H, Chou CK, Tsou PH, Hung MC, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). Journal of Biomaterials and Nanobiotechnology. 1: 31-36. PMID 21804949 DOI: 10.4236/Jbnb.2010.11004  0.565
2010 Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Research : Bcr. 12: R96. PMID 21080941 DOI: 10.1186/bcr2777  0.398
2010 Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 18: 423-35. PMID 21075308 DOI: 10.1016/j.ccr.2010.10.025  0.366
2010 Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochemical and Biophysical Research Communications. 403: 103-7. PMID 21040707 DOI: 10.1016/J.Bbrc.2010.10.126  0.813
2010 Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. The Analyst. 135: 2907-12. PMID 20877860 DOI: 10.1039/C0An00229A  0.491
2010 Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H, Do KA, Zheng Y, Hung MC, Mills GB, Meric-Bernstam F. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Molecular Cancer Therapeutics. 9: 2770-84. PMID 20876744 DOI: 10.1158/1535-7163.MCT-09-0980  0.386
2010 Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Research. 70: 7684-9. PMID 20841468 DOI: 10.1158/0008-5472.Can-09-3231  0.822
2010 Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America. 107: 16125-30. PMID 20802156 DOI: 10.1073/Pnas.1000743107  0.394
2010 Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN, Hung MC. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation Oncogene. 29: 5619-5629. PMID 20676141 DOI: 10.1038/Onc.2010.295  0.629
2010 Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M, Hung MC. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Research. 70: 5096-108. PMID 20501832 DOI: 10.1158/0008-5472.Can-09-4148  0.66
2010 Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab On a Chip. 10: 1793-8. PMID 20498894 DOI: 10.1039/C002937H  0.514
2010 Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Research. 70: 4709-18. PMID 20484037 DOI: 10.1158/0008-5472.Can-09-4524  0.834
2010 Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3171-81. PMID 20423983 DOI: 10.1158/1078-0432.Ccr-09-3171  0.48
2010 Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. Plos One. 5: e10105. PMID 20419128 DOI: 10.1371/Journal.Pone.0010105  0.43
2010 Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biology. 12: 457-67. PMID 20383141 DOI: 10.1038/Ncb2047  0.346
2010 Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Research. 70: 2424-34. PMID 20215498 DOI: 10.1158/0008-5472.Can-09-0878  0.819
2010 Kuo HP, Hung MC. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? American Journal of Translational Research. 2: 56-64. PMID 20182582  0.72
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2010 Hong S, Sreenivasappa H, Yamaguchi H, Wang Y, Chou C, Hung M, Kameoka J. Raster Image Correlation Spectroscopy for Anti-Cancer Drug Screening Based on the Identification of Molecular Dynamics Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2185  0.608
2009 Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC, Hortobagyi GN, Ueno NT. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer Clinical Cancer Research. 15: 6639-6648. PMID 19825949 DOI: 10.1158/1078-0432.CCR-09-0951  0.369
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2009 Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochemical and Biophysical Research Communications. 389: 640-4. PMID 19766100 DOI: 10.1016/j.bbrc.2009.09.042  0.793
2009 Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, Feng X, Seewaldt VL, Muller WJ, Sahin A, Hung MC, et al. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 16: 195-207. PMID 19732720 DOI: 10.1016/J.Ccr.2009.08.010  0.67
2009 Jiralerspong S, Gonzalez-Angulo AM, Hung MC. Expanding the arsenal: metformin for the treatment of triple-negative breast cancer? Cell Cycle (Georgetown, Tex.). 8: 2681. PMID 19717981 DOI: 10.4161/Cc.8.17.9502  0.388
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2009 Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A, Prieto VG, Hung MC, Bar-Eli M. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. The Journal of Biological Chemistry. 284: 28845-55. PMID 19703903 DOI: 10.1074/Jbc.M109.042150  0.307
2009 Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Molecular Cancer Therapeutics. 8: 2375-82. PMID 19671744 DOI: 10.1158/1535-7163.Mct-09-0056  0.308
2009 Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Molecular Carcinogenesis. 48: 1048-58. PMID 19526459 DOI: 10.1002/Mc.20557  0.818
2009 Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, Hsu L, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 3297-302. PMID 19487376 DOI: 10.1200/Jco.2009.19.6410  0.328
2009 Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 28: 2436-45. PMID 19448664 DOI: 10.1038/Onc.2009.98  0.803
2009 Cheng X, Hung MC. Regulation of breast cancer metastasis by atypical chemokine receptors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2951-3. PMID 19383808 DOI: 10.1158/1078-0432.CCR-09-0141  0.678
2009 Hawthorne VS, Huang WC, Neal CL, Tseng LM, Hung MC, Yu D. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Molecular Cancer Research : McR. 7: 592-600. PMID 19372587 DOI: 10.1158/1541-7786.Mcr-08-0316  0.841
2009 Neal CL, Yao J, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, Hittelman W, Hung MC, Yu D. 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Research. 69: 3425-32. PMID 19318578 DOI: 10.1158/0008-5472.Can-08-2765  0.83
2009 Huang WC, Hung MC. Induction of Akt activity by chemotherapy confers acquired resistance. Journal of the Formosan Medical Association = Taiwan Yi Zhi. 108: 180-94. PMID 19293033 DOI: 10.1016/S0929-6646(09)60051-6  0.319
2009 Hung MC, Mills GB, Yu D. Oxygen sensor boosts growth factor signaling. Nature Medicine. 15: 246-7. PMID 19265822 DOI: 10.1038/Nm0309-246  0.509
2009 Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Research. 69: 1343-9. PMID 19190323 DOI: 10.1158/0008-5472.Can-08-4153  0.378
2009 Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 752-7. PMID 19188143 DOI: 10.1158/1078-0432.CCR-08-0124  0.838
2009 Xia W, Wei Y, Du Y, Liu J, Chang B, Yu YL, Huo LF, Miller S, Hung MC. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Molecular Carcinogenesis. 48: 610-7. PMID 19058255 DOI: 10.1002/Mc.20504  0.398
2009 Ueno N, Kazansky A, LaFortune T, Lucci A, Krishnamurthy S, Hung M, Hortobagyi G, Woodward W, Reuben J, Robertson F, Cristofanilli M, Zhang D. Suppression of mesenchymal phenotype in inflammatory breast cancer by EGFR tyrosine kinase inhibitor erlotinib: a novel approach to suppressing metastasis. Cancer Research. 69: 2042. DOI: 10.1158/0008-5472.Sabcs-2042  0.427
2009 Sher Y, Tzeng T, Kan S, Hsu J, Xie X, Han Z, Lin W, Li L, Hung M. Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival Oncogene. 28: 3286-3295. DOI: 10.1038/Onc.2009.187  0.438
2008 Tsou PH, Chou CK, Saldana S, Hung MC, Kameoka J. The fabrication and testing of electrospun silica nanofiber membranes for the detection of proteins. Nanotechnology. 19: 445714. PMID 19081800 DOI: 10.1088/0957-4484/19/44/445714  0.513
2008 Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Research. 68: 8661-6. PMID 18974106 DOI: 10.1158/0008-5472.Can-08-1082  0.433
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2007 Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle (Georgetown, Tex.). 6: 3011-4. PMID 18073529 DOI: 10.4161/cc.6.24.5085  0.78
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2007 Cheng X, Hung MC. Breast cancer brain metastases. Cancer Metastasis Reviews. 26: 635-43. PMID 17717635 DOI: 10.1007/s10555-007-9083-x  0.66
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2007 Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Research. 67: 4564-71. PMID 17495324 DOI: 10.1158/0008-5472.CAN-06-1788  0.824
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2007 Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Molecular and Cellular Biology. 27: 4006-17. PMID 17387146 DOI: 10.1128/Mcb.00620-06  0.736
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2006 Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation Molecular and Cellular Biology. 26: 7269-7282. PMID 16980628 DOI: 10.1128/MCB.00172-06  0.814
2006 Xia WY, Lien HC, Wang SC, Pan Y, Sahin A, Kuo YH, Chang KJ, Zhou X, Wang H, Yu Z, Hortobagyi G, Shi DR, Hung MC. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. Breast Cancer Research and Treatment. 98: 295-301. PMID 16752078 DOI: 10.1007/S10549-006-9162-7  0.728
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2006 Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 9: 209-23. PMID 16530705 DOI: 10.1016/j.ccr.2006.02.018  0.301
2006 Day CP, Rau KM, Qiu L, Liu CW, Kuo HP, Xie X, Lopez-Berestein G, Hortobagyi GN, Hung MC. Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model. Cancer Gene Therapy. 13: 706-19. PMID 16514421 DOI: 10.1038/sj.cgt.7700945  0.83
2006 Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff M. Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Molecular Cancer Therapeutics. 5: 317-28. PMID 16505105 DOI: 10.1158/1535-7163.Mct-05-0350  0.632
2006 Chen IF, Ou-Yang F, Hung JY, Liu JC, Wang H, Wang SC, Hou MF, Hortobagyi GN, Hung MC. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Molecular Cancer Therapeutics. 5: 1-7. PMID 16432157 DOI: 10.1158/1535-7163.Mct-05-0310  0.468
2006 Chou CK, Hung JY, Liu JC, Chen CT, Hung MC. An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein. Cancer Gene Therapy. 13: 746-52. PMID 16410824 DOI: 10.1038/Sj.Cgt.7700927  0.577
2006 Ou-Yang F, Lan KL, Chen CT, Liu JC, Weng CL, Chou CK, Xie X, Hung JY, Wei Y, Hortobagyi GN, Hung MC. Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells. Cancer Research. 66: 378-84. PMID 16397252 DOI: 10.1158/0008-5472.CAN-05-1578  0.589
2006 Hanada N, Lo HW, Day CP, Pan Y, Nakajima Y, Hung MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis. 45: 10-7. PMID 16299810 DOI: 10.1002/mc.20147  0.696
2006 Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Research and Treatment. 95: 211-8. PMID 16261406 DOI: 10.1007/s10549-005-9011-0  0.349
2006 Bisanz K, Yu J, Rajbhandari I, Spohn B, Hung M, Chung LWK, Hsieh C. 1002. L1 Cell Adhesion Molecule, a Novel Target of Prostate Cancer Gene Therapy Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1096  0.373
2005 Wang SC, Hung MC. Cytoplasmic/nuclear shuttling and tumor progression. Annals of the New York Academy of Sciences. 1059: 11-5. PMID 16382038 DOI: 10.1196/annals.1339.002  0.371
2005 Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and Cellular Biology. 25: 11005-18. PMID 16314522 DOI: 10.1128/MCB.25.24.11005-11018.2005  0.737
2005 Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (New York, N.Y.). 310: 306-10. PMID 16224021 DOI: 10.1126/science.1118947  0.791
2005 Rau KM, Kang HY, Cha TL, Miller SA, Hung MC. The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers. Endocrine-Related Cancer. 12: 511-32. PMID 16172190 DOI: 10.1677/erc.1.01026  0.631
2005 Bartholomeusz C, Itamochi H, Yuan LX, Esteva FJ, Wood CG, Terakawa N, Hung MC, Ueno NT. Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model. Cancer Research. 65: 8406-13. PMID 16166319 DOI: 10.1158/0008-5472.CAN-05-1754  0.343
2005 Lo HW, Day CP, Hung MC. Cancer-Specific Gene Therapy Advances in Genetics. 54: 233-255. PMID 16096014 DOI: 10.1016/S0065-2660(05)54010-0  0.734
2005 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, ... Hung MC, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 19: 159-70. PMID 16039586 DOI: 10.1016/j.molcel.2005.06.009  0.786
2005 Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Research. 65: 3257-63. PMID 15833858 DOI: 10.1158/0008-5472.Can-04-1284  0.338
2005 Shao R, Lee DF, Wen Y, Ding Y, Xia W, Ping B, Yagita H, Spohn B, Hung MC. E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation. Molecular Cancer Research : McR. 3: 219-26. PMID 15831675 DOI: 10.1158/1541-7786.Mcr-04-0084  0.818
2005 Cha TL, Qiu L, Chen CT, Wen Y, Hung MC. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Research. 65: 2287-95. PMID 15781642 DOI: 10.1158/0008-5472.Can-04-3250  0.722
2005 Dong J, Peng J, Zhang H, Mondesire WH, Jian W, Mills GB, Hung MC, Meric-Bernstam F. Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Cancer Research. 65: 1961-72. PMID 15753396 DOI: 10.1158/0008-5472.CAN-04-2501  0.32
2005 Pawlik TM, Fritsche H, Coombes KR, Xiao L, Krishnamurthy S, Hunt KK, Pusztai L, Chen JN, Clarke CH, Arun B, Hung MC, Kuerer HM. Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry. Breast Cancer Research and Treatment. 89: 149-57. PMID 15692757 DOI: 10.1007/S10549-004-1710-4  0.377
2005 Zhou BP, Li Y, Hung MC. HER-2/Neu signaling and therapeutic approaches in breast cancer. Breast Disease. 15: 13-24. PMID 15687642 DOI: 10.3233/BD-2002-15103  0.328
2005 Lo HW, Xia W, Wei Y, Ali-Seyed M, Huang SF, Hung M. Erratum: Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer (Cancer Research (January 1, 2005) 65 (338-348)) Cancer Research. 65. DOI: 10.1158/0008-5472.Can-655Cor  0.393
2005 Xie X, Li Z, Ding Q, Kuo H, Abbruzzese JL, Hung M. 82. Targeted Pancreatic Cancer-Specific Gene Therapy Controlled by a Molecular-Engineered Human Cholecystokinin Type-A Receptor (CCKAR) Promoter in In Vivo Imaging Models Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.060  0.443
2004 Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 64: 9080-5. PMID 15604276 DOI: 10.1158/0008-5472.Can-04-2419  0.789
2004 Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 6: 459-69. PMID 15542430 DOI: 10.1016/J.Ccr.2004.09.027  0.801
2004 Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 6: 251-61. PMID 15380516 DOI: 10.1016/j.ccr.2004.07.012  0.788
2004 Chen JS, Liu JC, Shen L, Rau KM, Kuo HP, Li YM, Shi D, Lee YC, Chang KJ, Hung MC. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Therapy. 11: 740-7. PMID 15359286 DOI: 10.1038/sj.cgt.7700752  0.742
2004 Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 6: 117-27. PMID 15324695 DOI: 10.1016/J.Ccr.2004.06.022  0.821
2004 Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3815-24. PMID 15173090 DOI: 10.1158/1078-0432.CCR-03-0527  0.785
2004 Nahta R, Takahashi T, Ueno NT, Hung MC, Esteva FJ. P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Research. 64: 3981-6. PMID 15173011 DOI: 10.1158/0008-5472.Can-03-3900  0.359
2004 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 117: 225-37. PMID 15084260 DOI: 10.1016/S0092-8674(04)00302-2  0.843
2004 Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Research. 64: 2343-6. PMID 15059883 DOI: 10.1158/0008-5472.Can-03-3856  0.349
2004 Makino K, Day CP, Wang SC, Li YM, Hung MC. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene. 23: 3883-7. PMID 15021910 DOI: 10.1038/sj.onc.1207485  0.704
2004 Lee CM, Lo HW, Shao RP, Wang SC, Xia W, Gershenson DM, Hung MC. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. Cancer Research. 64: 1788-93. PMID 14996741 DOI: 10.1158/0008-5472.CAN-03-2551  0.338
2004 Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Molecular Carcinogenesis. 39: 139-46. PMID 14991743 DOI: 10.1002/Mc.10169  0.601
2004 Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 23: 1896-901. PMID 14981540 DOI: 10.1038/sj.onc.1207314  0.823
2004 Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F. Determinants of rapamycin sensitivity in breast cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1013-23. PMID 14871980 DOI: 10.1158/1078-0432.CCR-03-0043  0.312
2004 Day C, Rau K, Hung M. [abstract] Selective breast tumor growth suppression mediated by the enhanced breast cancer-specific promoter Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.237  0.753
2003 Li YM, Wen Y, Zhou BP, Kuo HP, Ding Q, Hung MC. Enhancement of Bik antitumor effect by Bik mutants. Cancer Research. 63: 7630-3. PMID 14633680  0.802
2003 Zhou BP, Hung MC. Dysregulation of cellular signaling by HER2/neu in breast cancer. Seminars in Oncology. 30: 38-48. PMID 14613025 DOI: 10.1053/J.SEMINONCOL.2003.08.006  0.354
2003 Lee WP, Tai DI, Tsai SL, Yeh CT, Chao Y, Lee SD, Hung MC. Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine. Cancer Research. 63: 6229-36. PMID 14559808  0.566
2003 Liao Y, Hung MC. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Molecular and Cellular Biology. 23: 6836-48. PMID 12972603 DOI: 10.1128/MCB.23.19.6836-6848.2003  0.328
2003 Wen Y, Giri D, Yan DH, Spohn B, Zinner RG, Xia W, Thompson TC, Matusik RJ, Hung MC. Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Molecular Carcinogenesis. 37: 130-7. PMID 12884364 DOI: 10.1002/Mc.10129  0.594
2003 Chen JS, Lan K, Hung MC. Strategies to target HER2/neu overexpression for cancer therapy Drug Resistance Updates. 6: 129-136. PMID 12860460 DOI: 10.1016/S1368-7646(03)00040-2  0.335
2003 Najafi SM, Li Z, Makino K, Shao R, Hung MC. The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells. Biochemical and Biophysical Research Communications. 305: 1099-104. PMID 12767945 DOI: 10.1016/S0006-291X(03)00905-7  0.311
2002 Kwong KY, Zou Y, Day CP, Hung MC. The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Oncogene. 21: 8340-6. PMID 12447697 DOI: 10.1038/sj.onc.1206050  0.707
2002 Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell. 2: 323-34. PMID 12398896 DOI: 10.1016/S1535-6108(02)00154-X  0.59
2002 Lee S, Yang W, Lan KH, Sellappan S, Klos K, Hortobagyi G, Hung MC, Yu D. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer Research. 62: 5703-10. PMID 12384528  0.831
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2002 Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proceedings of the National Academy of Sciences of the United States of America. 99: 12747-52. PMID 12242338 DOI: 10.1073/pnas.202162199  0.362
2002 Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene. 21: 6278-88. PMID 12214268 DOI: 10.1038/Sj.Onc.1205761  0.322
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2000 Meric F, Liao Y, Lee WP, Pollock RE, Hung MC. Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 3832-6. PMID 11051226  0.639
2000 Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. The Journal of Biological Chemistry. 275: 36238-44. PMID 10945974 DOI: 10.1074/Jbc.M002138200  0.492
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2000 Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 97: 4262-6. PMID 10759547 DOI: 10.1073/Pnas.060025397  0.633
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